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Zhixin Zhang, Lingling Qin, Long Peng, Qingqing Zhang, Qing Wang, Zhiwei Lu, Yuelin Song, Xiaoyan Gao
Qingkailing injection (QKLI) is a modern Chinese medicine preparation derived from a well-known classical formulation, An-Gong-Niu-Huang Wan. Although the clinical efficacy of QKLI has been well defined, its severe adverse drug reactions (ADRs) were extensively increased. Through thorough attempts to reduce ADR rates, it was realized that the effect-based rational use plays the key role in clinical practices. Hence, the pharmacokinetic-pharmacodynamic (PK-PD) model was introduced in the present study, aiming to link the pharmacokinetic profiles with the therapeutic outcomes of QKLI, and subsequently to provide valuable guidelines for the rational use of QKLI in clinical settings...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Huimin Cao, Beibei Chen, Yushuang Deng, Xi Lu, Gang Yu
OBJECTIVE: To investigate the protective effect and related mechanism of baicalin in murine neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (APP) (N2a/APPswe cells), a cellular model of Alzheimer' s disease (AD). METHODS: MTT assay was performed to observe the effect of baicalin (0.1, 0.5, 1, 5, 10, 20) μmol/L on the viability of N2a/APPswe cells. After N2a/APPswe cells were incubated with (1, 5, 10) μmol/L baicalin for 48 hours, xanthine oxidase assay was used to test superoxide dismutase (SOD) activity and thiobarbituric acid method to detect malondialdehyde (MDA) content in each group...
December 2015: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
Min Li, Aixin Shi, Hongxian Pang, Wei Xue, Yang Li, Guoying Cao, Bei Yan, Fan Dong, Kexin Li, Wei Xiao, Guorong He, Guanhua Du, Xin Hu
ETHNOPHARMACOLOGICAL RELEVANCE: The root of Scutellaria baicalensis Georgi has been used extensively in traditional Chinese medicine for the treatment of inflammation, fever, cough, dysentery, and hypertension. Baicalein is a flavonoid isolated from the root of Scutellaria baicalensis Georgi and is a novel neuroprotective agent under development for the treatment of Parkinson׳s disease. We aimed to investigate the pharmacokinetic (PK) properties of baicalein and its main metabolite, bacalin, after single-dose administration in healthy Chinese subjects...
October 28, 2014: Journal of Ethnopharmacology
Meng-Liang Zhu, Xin-Li Liang, Li-Jun Zhao, Zheng-Gen Liao, Guo-Wei Zhao, Yun-Chao Cao, Jing Zhang, Yun Luo
ETHNOPHARMACOLOGICAL RELEVANCE: Angelicae Dahurica (Hoffm.) Benth. & Hook. f. ex Franch. & Sav combined with Radix Scutellariae baicalensis Georgi has been widely used in traditional Chinese medicine (TCM) as an antipyretic analgesic and anti-inflammatory drug. Modern pharmacological studies have demonstrated that the compatible application of these two drugs is an effective treatment for hepatitis. A previous study indicated that a Radix Angelicae Dahuricae extract enhanced the intestinal absorption of the baicalin found in Radix Scutellariae; however, the underlying compatibility mechanism of these two herbs remains unknown...
November 25, 2013: Journal of Ethnopharmacology
Ming-Shu Xu, Shuo Chen, Wen-Quan Wang, Si-Qin Liu
A cost-effective and environmentally friendly approach was developed to improve the extraction of active ingredients from plants, in which a bifunctional enzyme was employed for not only facilitating cell wall degradation but also increasing the bioactivity of target compounds in the extract. In the aqueous extraction of flavonoids from Glycyrrhizae radix, Trichoderma viride cellulase, a commercial cell-wall-degrading enzyme, was found to efficiently deglycosylate liquiritin and isoliquiritin, which are of high content but low bioactivity, into their aglycones that have much higher physiological activities for dietary and medicinal uses...
August 21, 2013: Journal of Agricultural and Food Chemistry
Yue Shi, Nan-Qi Ren, Yu-Ming Zhang, Rong-Xin Xiao
A laboratory-scale experiment was done. And the baicalin anaerobic biodegradation curve and pathway were discussed by analyzing the results of GC-MS. After analogue of status's trend and analysis of its regression, the biodegradation kinetic equation of baicalin was obtained. And the possible biodegradation pathway was "desugar --> debentures --> open benzene ring --> saturating --> disconnect links". It took at least 47 h to biodegrade baicalin. The main products of anaerobic biodegradation were micro-molecule oxide, such as alcohols, aldehydes, acids, esters, olefin, and hydrocarbon of methane series...
November 2007: Huan Jing Ke Xue= Huanjing Kexue
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