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Vitiligo, severity score

Hassan Ibrahim, Moustafa El Taieb, Zeinab El Gamel, Abdel Rahman El Saied
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly. OBJECTIVE: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation...
March 10, 2018: Journal of Cosmetic Dermatology
Dina R U Hasibuan, Imam B Putra, Nelva K Jusuf
BACKGROUND: Vitiligo is a chronic skin disorder. White macules caused by melanocyte destruction is a characteristic finding that cosmetically disturbing. Until recently, pathogenesis of vitiligo is still unclear. The role of homocysteine in vitiligo is mentioned in previous studies thus it is probable that it can be a biomarker to determine vitiligo severity. AIM: To determine correlation between serum homocysteine and vitiligo area Scoring Index (VASI). SUBJECT AND METHOD: This was a cross-sectional analytic study which involved 30 vitiligo patients that were diagnosed by clinical and Wood's lamp examinations then VASI score was determined and same numbers of control...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
Saba Zabetian, Gordon Jacobson, Henry W Lim, Melody J Eide, Richard H Huggins
<p>BACKGROUND: No study has examined the impact of vitiligo support group membership on vitiligo patient quality of life (QoL).</p> <p>OBJECTIVE: We sought to examine the QoL impact of vitiligo support groups by comparing QoL and associated patient characteristics between vitiligo patients who are and are not members of a vitiligo support group.</p> <p>METHODS: Members of a Henry Ford Hospital-sponsored, Southeast Michigan Vitiligo Support Group were compared to non-member vitiligo patients recruited from a previous study cohort...
April 1, 2017: Journal of Drugs in Dermatology: JDD
Momoko Yoshikawa, Yasuyuki Sumikawa, Tokimasa Hida, Takafumi Kamiya, Kimi Kase, Yasue Ishii-Osai, Junji Kato, Yuji Kan, Shiori Kamiya, Yuki Sato, Toshiharu Yamashita
Rhododendrol-induced leukoderma is an acquired depigmentation that develops mainly at the contact site after repeated use of skin-whitening cosmetics containing rhododendrol. In most cases, cessation of further depigmentation or occurrence of repigmentation is observed after discontinuing the use of cosmetics. However, some patients develop vitiligo vulgaris through the spread of depigmentation into the non-exposed areas. Our study aims to investigate the patient-specific factors that may affect the extent of depigmentation or repigmentation, as well as development of vitiligo vulgaris...
May 2017: Journal of Dermatology
Jinping Yuan, Hongqiang Chen, Ru Yan, Shaoshan Cui, Yuan-Hong Li, Yan Wu, Xing-Hua Gao, Hong-Duo Chen
BACKGROUND: Stable non-segmental vitiligo is often resistant to conventional therapies. OBJECTIVES: The purpose of this study was to investigate the effect of three types of fractional lasers in the treatment of stable non-segmental vitiligo. MATERIALS & METHODS: Twenty patients were enrolled in the study. The vitiligo lesions of each patient were divided into four treatment parts, and all parts were treated with narrowband ultraviolet-B (NB-UVB)...
December 1, 2016: European Journal of Dermatology: EJD
K H Mou, D Han, W L Liu, P Li
Glycyrrhizin has been used clinically for several years due to its beneficial effect on immunoglobulin E (IgE)-induced allergic diseases, alopecia areata and psoriasis. In this study, glycyrrhizin, ultraviolet B light (UVB) or a combination of both were used to treat active-stage generalized vitiligo. One hundred and forty-four patients between the ages of 3 and 48 years were divided into three groups: group A received oral compound glycyrrhizin (OCG); group B received UVB applications twice weekly, and group C received OCG+UVB...
July 25, 2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Romana Čeović, Lana Desnica, Dražen Pulanić, Ranka Serventi Seiwerth, Ivana Ilić, Magdalena Grce, Marinka Mravak Stipetić, Tajana Klepac Pulanić, Ervina Bilić, Ernest Bilić, Milan Milošević, Radovan Vrhovac, Damir Nemet, Steven Z Pavletic
AIM: To determine the frequency and the characteristics of cutaneous manifestations, especially vitiligo and alopecia areata, in patients with chronic graft-vs-host disease (cGVHD). METHODS: 50 patients with cGVHD were prospectively enrolled in the observational study protocol and evaluated by an experienced dermatologist. The evaluation was focused on the clinical spectrum of skin and adnexal involvement, and the cutaneous GVHD score was determined according to National Institutes of Health (NIH) Consensus criteria...
June 30, 2016: Croatian Medical Journal
Julien Seneschal, Katia Boniface
The extension and severity of vitiligo guide diagnosis, prognosis, and therapeutic choices. However, to date, the lack of a standardized method for measuring vitiligo is responsible for the high variability in vitiligo assessment. van Geel et al. introduce a clinical scoring called the Vitiligo Extent Score with a strong interest in clinical practice and clinical research in vitiligo.
May 2016: Journal of Investigative Dermatology
Dinesh Prasad Asati, C M Gupta, Shreyansh Tiwari, Sanjeev Kumar, Vishal Jamra
BACKGROUND: Vitiligo is one of the common stigmatizing dermatosis in the Indian society and the vitiligo patients have to face significant psychological hurt and social neglect. The severity of the stigma is related to the society's attitude and knowledge about it. AIMS AND OBJECTIVES: To document the prevalent knowledge and attitude in general public towards vitiligo patients, and to identify the determinants of good/poor knowledge and attitude. MATERIALS AND METHODS: A systematic random sampling technique was adopted to enroll 700 adult participants visiting an urban tertiary healthcare facility of central India...
January 2016: Journal of Natural Science, Biology, and Medicine
Andac Salman, Emel Kurt, Volkan Topcuoglu, Zeynep Demircay
BACKGROUND: Vitiligo and acne vulgaris, commonly affecting the face, have significant psychological effects and impair the quality of life of the affected individuals. Because of their negative effect on physical appearance, these conditions may act as a potential barrier to social relationships and cause social anxiety. OBJECTIVE: The objective of the study was to investigate the social anxiety, quality of life, anxiety, and depression levels of acne and vitiligo patients with facial involvement and compare these levels with healthy controls...
June 2016: American Journal of Clinical Dermatology
X X Wang, Q Q Wang, J Q Wu, M Jiang, L Chen, C F Zhang, L H Xiang
BACKGROUND: Vitiligo is a skin disorder characterized by loss of melanocytes from the epidermis. A recent study reported that CXCL10 is critical for the progression and maintenance of depigmentation in a mouse model of vitiligo, but there is very limited clinical data regarding this issue and little is known about the dynamic changes or correlations with disease severity of these chemokines throughout the disease course. OBJECTIVES: To present clinical data that supports and identifies the pathway of CXCR3 and its ligands in T-lymphocytic cell recruitment in vitiligo...
June 2016: British Journal of Dermatology
Juan Jesús Sosa, Sharif D Currimbhoy, Uzoamaka Ukoha, Samantha Sirignano, Ryan O'Leary, Travis Vandergriff, Linda S Hynan, Amit G Pandya
BACKGROUND: Confetti-like depigmentation was noted in patients reporting recent worsening of vitiligo. OBJECTIVE: We sought to determine if confetti-like depigmentation is a marker of rapidly progressing vitiligo. METHODS: Review of patient records and images of patients from a vitiligo registry resulted in 7 patients with 12 images that fit inclusion criteria and were evaluated for percent depigmentation by 3 independent reviewers. The Vitiligo Disease Activity Score and the Koebner Phenomenon in Vitiligo Score in an additional cohort of patients with confetti-like lesions were compared with patients who had vitiligo without confetti-like lesions...
August 2015: Journal of the American Academy of Dermatology
Gülcan Güntaş, Burhan Engin, Özlem Balcı Ekmekçi, Zekayi Kutlubay, Hakan Ekmekci, Abdullah Songür, Tuğba Kevser Üstünbaş Uzunçakmak, Hayriye Ertem Vehid, Server Serdaroğlu, Yalçın Tüzün, Hafize Uzun
BACKGROUND: Vitiligo is a chronic, common disease of unknown etiology, and oxidative stress is suggested to have a role in its etiopathogenesis. OBJECTIVE: Advanced oxidation protein products (AOPPs), prooxidant-antioxidant balance (PAB), and ferric-reducing antioxidant power (FRAP) were evaluated regarding their role in the pathogenesis of vitiligo as well as their relationship with clinical presentation and disease severity, and these parameters were compared with those of healthy controls...
April 2015: Annals of Dermatology
Lucybeth N Sangma, Jyoti Nath, Dipesh Bhagabati
BACKGROUND: Vitiligo is an acquired discoloration of skin and mucous membrane of great cosmetic importance affecting 1-4% of the world's population. It causes disfiguration in all races, more so in dark-skinned people because of strong contrast. Men, women, and children with vitiligo face severe psychological and social disadvantage. AIM: To assess the impact of the disease on the quality of life of patients suffering from vitiligo, also to ascertain any psychological morbidity like depression associated with the disease and to compare the results with that of healthy control group...
March 2015: Indian Journal of Dermatology
I Kohli, J Veenstra, I Hamzavi
No abstract text is available yet for this article.
February 2015: British Journal of Dermatology
N K Klimas, A D Shedd, I H Bernstein, H Jacobe
BACKGROUND: Little is known about the health-related quality of life (HRQoL) of patients with morphoea, and previous studies have yielded conflicting results. OBJECTIVES: To determine the impact of morphoea on HRQoL, and clinical and demographic correlates of HRQoL in adults. METHODS: This was a cross-sectional survey (n = 73) of the Morphea in Adults and Children cohort. RESULTS: Morphoea impairs HRQoL in adults. Patients were most impaired by emotional well-being and concerns that the disease would progress to internal organs...
2015: British Journal of Dermatology
Amir Feily
Although skin is the largest organ of the body, there are no standardized reproducible methods for assessing severity of many skin diseases. Due to lack of consensus, methods of assessment and inexistence of precise scoring system, there is no application for vitiligo estimation in real practice. In this paper the author describes VETI score as a new treatment evaluation criteria and severity assessment method for vitiligo. This new tool, as does the PASI score in psoriasis, may be able to produce a constant and reproducible number and to help clinical research on vitiligo patients...
October 2014: Dermatology Practical & Conceptual
Vito Ingordo, Simone Cazzaniga, Matelda Medri, Beatrice Raone, Maria Donata Digiuseppe, Maria Letizia Musumeci, Ivana Romano, Dario Fai, Michele Pellegrino, Enrico Pezzarossa, Vito Di Lernia, Francesca Peccerillo, Vincenzo Claudio Battarra, Riccardo Sirna, Annalisa Patrizi, Luigi Naldi
BACKGROUND: It is believed that vitiligo has an impact on the overall patient quality of life (QoL). OBJECTIVE: To estimate QoL in a fairly large sample of Italian vitiligo patients by using the Dermatology Life Quality Index (DLQI) questionnaire. METHODS: One hundred and sixty-one vitiligo patients referred to 9 dermatological centers were offered to participate by filling in the Italian version of the DLQI questionnaire. RESULTS: The mean total DLQI score was 4...
2014: Dermatology: International Journal for Clinical and Investigative Dermatology
L Komen, V da Graça, A Wolkerstorfer, M A de Rie, C B Terwee, J P W van der Veen
BACKGROUND: Vitiligo is a common skin disorder causing depigmented macules that can impair a patient's quality of life. Currently, there are no standardized outcome measures to assess the degree of depigmentation. Moreover, there is limited knowledge on the measurement properties of outcome measures in vitiligo. OBJECTIVES: To assess the reliability and responsiveness of the Vitiligo Area Scoring Index (VASI) and the Vitiligo European Task Force assessment (VETFa), two well-described clinician-reported outcomes...
February 2015: British Journal of Dermatology
G Khullar, A J Kanwar, S Singh, D Parsad
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is an effective and safe treatment for vitiligo. Calcipotriol, a synthetic analogue of 1,25 dihydroxyvitamin D3 may regulate melanin synthesis. Several clinical studies have been conducted but the synergistic effect of addition of calcipotriol to NB-UVB in the treatment of vitiligo is still debatable. OBJECTIVES: To compare the efficacy and safety of topical calcipotriol (0.005%) in combination with NB-UVB vs. NB-UVB alone in generalized vitiligo...
May 2015: Journal of the European Academy of Dermatology and Venereology: JEADV
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