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Gynecological cancer

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https://www.readbyqxmd.com/read/29474124/internet-use-by-gynecologic-oncology-patients-and-its-relationship-with-anxiety
#1
Dalia M Corrales, Ali E Wells, Carmen Radecki Breitkopf, Gabriela Pena, Alan L Kaplan, Lorrie S King, Sonia C Robazetti, Tri A Dinh
This study describes the use of the Internet for health information research by patients attending a gynecologic oncology practice and examines the association between its use and anxiety. A self-administered survey assessed patients' demographic information and Internet use. The Hospital Anxiety and Depression Scale (HADS) and the State-Trait Anxiety Inventory (STAI) were administered concurrently. Of 212 patients who consented to the study, 98 (46%) had an appointment because of a cancer diagnosis. Of 199 respondents, 91 (46%) reported searching the Internet for information about their condition...
February 23, 2018: Journal of Health Communication
https://www.readbyqxmd.com/read/29472312/complete-remission-following-pembrolizumab-in-a-woman-with-mismatch-repair-deficient-endometrial-cancer-and-a-germline-brca1-mutation
#2
Don S Dizon, Dora Dias-Santagata, Amy Bregar, Laura Sullivan, Jennifer Filipi, Elizabeth DiTavi, Lucy Miller, Leif Ellisen, Michael Birrer, Marcela DelCarmen
Endometrial cancer is the most common gynecologic malignancy in the U.S. and, although the majority of cases present at an early stage and can be treated with curative intent, those who present with advanced disease, or develop metastatic or recurrent disease, have a poorer prognosis. A subset of endometrial cancers exhibit mismatch repair (MMR) deficiency. It is now recognized that MMR-deficient cancers are particularly susceptible to programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) inhibitors, and in a landmark judgement in 2017, the U...
February 22, 2018: Oncologist
https://www.readbyqxmd.com/read/29472031/preoperative-mr-imaging-for-esmo-esgo-estro-classification-of-endometrial-cancer
#3
P Lavaud, B Fedida, G Canlorbe, S Bendifallah, E Darai, I Thomassin-Naggara
OBJECTIVE: To retrospectively investigate whether magnetic resonance imaging (MRI) findings could contribute to predict histologic type, tumor grade and lymphovascular space invasion (LVSI) to improve preoperative assessment of endometrial cancer using the European Society for Medical Oncology (ESMO) European Society for Radiotherapy & Oncology (ESTRO) and European Society of Gynecological Oncology (ESGO) classification. METHODS: Between January 2008 and August 2014, 104 women (mean age, 65±11 [SD] years; range, 32-84 years) with International Federation of Gynecology and Obstetrics (FIGO) stage I endometrial cancer underwent preoperative MRI of the pelvis...
February 19, 2018: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29472016/opioid-use-in-gynecologic-oncology-in-the-age-of-the-opioid-epidemic-part-i-effective-opioid-use-across-clinical-settings-a-society-of-gynecologic-oncology-evidence-based-review
#4
Carolyn Lefkowits, Mary K Buss, Amin A Ramzan, Stacy Fischer, Renata R Urban, Christine M Fisher, Linda R Duska
As the only oncologists that provide both medical and surgical oncologic care, gynecologic oncologists encounter an exceptionally broad range of indications for prescribing opioids, from management of acute post-operative pain to chronic cancer-related pain to end-of-life care. If we are to balance opioid efficacy, safety and accessibility for our patients, we must be intimately familiar with appropriate clinical use of opioids in a range of settings, and engage in the national conversation around opioid misuse and how associated regulations and legislation may impact us and our patients...
February 20, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29470187/the-danish-gynecological-cancer-nursing-database-creating-evidence-for-quality-improvements-in-preoperative-and-postoperative-cancer-care
#5
Lene Seibæk, Dorthe Hjort Jakobsen, Claus Høgdall
OBJECTIVE: Quality of preoperative and postoperative care is crucial to improve postoperative outcome of cancer surgery and to ensure that neither complications nor a poor general condition delays any subsequent radiochemotherapy or recovery. On this background, the Danish Gynecological Cancer Database (DGCD) established a nursing database in 2011. The aim of DGCD Nursing is to monitor the quality of preoperative and postoperative care and to generate data for research. MATERIAL AND METHODS: In accordance with the current data protection legislation, real-time data are entered by clinical nurses at all national cancer centers...
February 22, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29469083/knowledge-attitude-and-practice-toward-cervical-cancer-among-women-attending-obstetrics-and-gynecology-department-a-cross-sectional-hospital-based-survey-in-south-india
#6
G Narayana, M Jyothi Suchitra, G Sunanda, J Dasaratha Ramaiah, B Pradeep Kumar, K V Veerabhadrappa
INTRODUCTION: Cervical cancer-related deaths among women in India are often due to late diagnosis of disease. Knowledge about disease and early screening is the most effective measure for cervical cancer prevention. Lack of awareness, negative attitude, and poor practice about cervical cancer and screening are the major causes to increase the incidence of disease. AIM: The study is designed to assess knowledge, attitude, and practice (KAP) toward cervical cancer, screening, and prevention...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29469078/barriers-affecting-adherence-to-radiation-treatment-and-strategies-to-overcome-those-barriers
#7
R Rangarajan, K Jayaraman
BACKGROUND: The WHO defines adherence as the extent to which a patient's behavior coincides with recommendations from a health-care provider. Nonadherence to cancer treatment has a major impact on the therapeutic outcome. AIM OF THE STUDY: To assess the prevalence of nonadherence to radiation regimen and to analyze the factors that affect adherence to cancer treatment. MATERIALS AND METHODS: Patients receiving radiation treatment in our hospital were screened for adherence to appointment keeping and to the prescribed radiation regimen and patients who had unplanned treatment breaks during treatment were interviewed...
April 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29468856/chemoresistance-in-ovarian-cancer-exploiting-cancer-stem-cell-metabolism
#8
REVIEW
Shan Shan Li, Jing Ma, Alice S T Wong
Ovarian cancer is most deadly gynecologic malignancies worldwide. Chemotherapy is the mainstay treatment for ovarian cancer. Despite the initial response is promising, frequent recurrence in patients with advanced diseases remains a therapeutic challenge. Thus, understanding the biology of chemoresistance is of great importance to overcome this challenge and will conceivably benefit the survival of ovarian cancer patients. Although mechanisms underlying the development of chemoresistance are still ambiguous, accumulating evidence has supported an integral role of cancer stem cells (CSCs) in recurrence following chemotherapy...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29468855/major-clinical-research-advances-in-gynecologic-cancer-in-2017
#9
REVIEW
Dong Hoon Suh, Miseon Kim, Kyung Hun Lee, Keun Yong Eom, Maj Kamille Kjeldsen, Mansoor Raza Mirza, Jae Weon Kim
In 2017, 10 topics were selected as major clinical research advances in gynecologic oncology. For cervical cancer, efficacy and safety analysis results of a 9-valent human papillomavirus (HPV) vaccine and long-term impact of reduced dose of quadrivalent vaccine were updated. Brief introduction of KEYNOTE trials of pembrolizumab, a monoclonal antibody that blocks the interaction between programmed death (PD)-1 and its ligands, PD-L1 and PD-L2, followed. Tailored surveillance programs for gynecologic cancer related with Lynch syndrome and update on sentinel lymph node mapping were reviewed for uterine corpus cancer...
March 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29467885/paclitaxel-plus-nedaplatin-vs-paclitaxel-plus-carboplatin-in-women-with-epithelial-ovarian-cancer-a-multi-center-randomized-open-label-phase-iii-trial
#10
Li Li, Qingqing Zhuang, Zeyi Cao, Rutie Yin, Yaping Zhu, Lirong Zhu, Xing Xie, Youzhong Zhang, Li Li, Qiang Wu, Jianhua Zheng, Qi Zhou, Xiaoping Li, Lingying Wu, Youji Feng, Changyu Wang
The multi-center, randomized, open-label, phase III trial discussed in the present study was performed to compare the clinical outcomes of nedaplatin (NDP) plus paclitaxel, and carboplatin (CBP) plus paclitaxel for the treatment of epithelial ovarian cancer (EOC). In the current study, 182 patients with International Federation of Gynecology and Obstetrics (FIGO) stage II-IV EOC were randomly assigned to receive NDP plus paclitaxel or CBP plus paclitaxel at 3-week intervals for a total of six courses. The primary endpoints were progression-free survival rate (PFS) and overall survival rate (OS)...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29466348/perceived-needs-preparedness-and-emotional-distress-of-male-caregivers-of-postsurgical-women-with-gynecologic-cancer
#11
Susan R Mazanec, Dianne Reichlin, Haley Gittleman, Barbara J Daly
OBJECTIVES: To describe the perceived needs, preparedness, and emotional distress of male caregivers of postsurgical patients with gynecologic cancer during the transition from hospital to home. 
. SAMPLE & SETTING: 50 male caregivers of patients with gynecologic cancer on an inpatient unit at University Hospitals Seidman Cancer Center in Cleveland, OH.
. METHODS & VARIABLES: Caregiver needs, perceived preparedness, and emotional distress were measured at admission and at one week postdischarge...
March 1, 2018: Oncology Nursing Forum
https://www.readbyqxmd.com/read/29466257/recurrent-cancer-is-associated-with-dissatisfaction-with-care-a-longitudinal-analysis-among-ovarian-and-endometrial-cancer-patients
#12
Belle H de Rooij, Habibe Ikiz, Dorry Boll, Johanna M A Pijnenborg, Brenda M Pijlman, Roy F P M Kruitwagen, Lonneke V van de Poll-Franse, M Caroline Vos, Nicole P M Ezendam
OBJECTIVE: The primary aim of this study was to assess the longitudinal impact of a recurrence of gynecological cancer on satisfaction with information provision and care. The secondary aim was to assess the impact of a recurrence on illness perceptions, anxiety, and depression and health-related quality of life. METHODS: This study is a longitudinal analysis from the ROGY Care trial, conducted between 2011 and 2014, including patients with endometrial (n = 215) and ovarian (n = 149) cancer...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29466256/the-impact-of-an-enhanced-recovery-after-surgery-program-on-patients-treated-for-gynecologic-cancer-in-the-community-hospital-setting
#13
Alberto A Mendivil, Justin R Busch, David C Richards, Heather Vittori, Bram H Goldstein
OBJECTIVES: The purpose of this study was to compare the outcomes of gynecologic oncology patients treated in the community hospital setting either under the auspices of an enhanced recovery after surgery (ERAS) protocol or in accordance with physician discretion. METHODS: We retrospectively evaluated a series of consecutive gynecologic oncology patients who were managed via open surgery in coincident with an ERAS pathway from January 2015 to December 2016. They were compared with a historical open surgery cohort who was treated from November 2013 to December 2014...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29466254/characteristics-and-prognosis-of-stage-i-ovarian-mucinous-tumors-according-to-expansile-or-infiltrative-type
#14
Sebastien Gouy, Marine Saidani, Amandine Maulard, Slim Bach-Hamba, Enrica Bentivegna, Alexandra Leary, Patricia Pautier, Mojgan Devouassoux-Shisheboran, Catherine Genestie, Philippe Morice
BACKGROUND: The present study retrospectively determined the outcomes and prognoses in stage I mucinous ovarian carcinoma according to histological type (ie, expansile or infiltrative). METHODS: A centralized pathologic review of tumors in patients treated from 1976 to 2016 for ovarian mucinous carcinoma was performed by 2 expert pathologists according to the 2014 World Health Organization classification. Only patients with stage I disease were analyzed. Tumors were typed as expansile or infiltrative and oncological issues analyzed...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29466248/four-common-polymorphisms-of-brip1-rs2048718-rs4988344-rs4986764-and-rs6504074-and-cancer-risk-evidence-from-13-716-cancer-patients-and-15-590-cancer-free-controls
#15
Di Liu, Yi Zheng, Meng Wang, Yujiao Deng, Shuai Lin, Linghui Zhou, Pengtao Yang, Cong Dai, Peng Xu, Qian Hao, Dingli Song, Huafeng Kang, Zhijun Dai
Previous studies have showed the associations between various BRCA1-interacting protein 1 ( BRIP1 ) polymorphisms and cancer risk. But, these results were inconsistent. This meta-analysis based on 18 studies involving 13,716 cancer patients and 15,590 cancer-free controls is aimed at to evaluate the relationship between the four common SNPs of BRIP1 (rs2048718, rs4988344, rs4986764, and rs6504074) and cancer risk. The results showed a decreased risk of rs2048718 or rs4986764 for cervical cancer rather than breast cancer in the overall population ( P < 0...
February 16, 2018: Aging
https://www.readbyqxmd.com/read/29465508/impact-of-hormone-receptor-status-and-ki-67-expression-on-disease-free-survival-in-patients-affected-by-high-risk-endometrial-cancer
#16
Violante Di Donato, Valentina Iacobelli, Michele Carlo Schiavi, Vanessa Colagiovanni, Irene Pecorella, Innocenza Palaia, Giorgia Perniola, Claudia Marchetti, Angela Musella, Federica Tomao, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici
OBJECTIVES: The aim of this study was to evaluate the immunohistochemical (IHC) expression of Ki-67, estrogen receptors α (ERsα), and progesterone receptors (PRs) in high-risk endometrial cancer patients and to assess their prognostic impact. METHODS/MATERIALS: Immunohistochemical expression of Ki-67, ERsα, and PRs was evaluated in primary untreated endometrial cancer. The correlation among IHC staining and risk factors of recurrence such as age, Federation International of Gynecology and Obstetrics stage, grading, depth of invasion, and metastatic spread was assessed...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29465505/mutational-aberrations-detected-in-mucinous-epithelial-ovarian-cancer-of-asian-women
#17
Wen Yee Chay, Li Lian Kwok, Wen Ning Tiong, Sai Sakktee Krisna, Kiat Hon Lim, N Gopalkrishna Iyer, Liang Kee Goh, Daniel Shao-Weng Tan
BACKGROUND: Mucinous epithelial ovarian cancers (mEOCs) respond poorly to conventional chemotherapy and have a poor prognosis in advanced stages. The genomic landscape for mEOC in the Asian settings is ill defined. We seek to identify various mutational aberrations present in mEOC and correlate them with clinical outcomes. METHODS: A total of 199 cases of mEOC were identified from a prospectively maintained gynecologic oncology tumor database. DNA was extracted and analyzed for KRAS mutations by using Sanger sequencing...
March 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29464888/postoperative-cytological-findings-from-the-use-of-the-integran-microfibrillar-collagen-hemostatic-matrix-in-conization
#18
Shinji Toyoda, Hiroshi Okada, Hideo Tsujino, Yoshinori Takeda, Atsushi Sugiura, Yoshio Itani, Tsunekazu Kita, Eiwa Ishida
The Integran microfibrillar collagen hemostatic matrix is one form of microfibrillar collagen hemostat. This form has a sheet-type structure and has explicitly been used in Japan. In gynecology, this sheet-type matrix has helped effect uterine surface hemostasis, especially in myomectomy and cervical conization. However, cytotechnologists and pathologists have overlooked the foreign materials used for conization in postoperative cervical cytology. We report two cases describing the characteristic cervical cytology findings when Integran was used in conization...
February 21, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29463474/sexual-self-schema-scale-for-women-validation-and-psychometric-properties-of-the-polish-version
#19
Krzysztof Nowosielski, Konrad S Jankowski, Robert Kowalczyk, Jacek Kurpisz, Małgorzata Normantowicz-Zakrzewska, Aleksandra Krasowska
INTRODUCTION: The sexual self-schema is a part of a broader concept of the self that is believed to be crucial for intrapersonal and interpersonal sexual relationships. AIM: To develop and perform psychometric validation of the Polish version of the Sexual Self-Schema Scale for Women (SSSS-W-PL). METHODS: 561 women 18 to 55 years old were included in the final analysis. Linguistic validation was performed in 4 steps in line with the MAPI Institute guidelines...
February 17, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/29463092/super-utilization-of-health-care-resources-among-gynecologic-oncology-patients
#20
Casey M Hay, Joseph L Kelley, Robert P Edwards, Kathleen M Pombier, John T Comerci
Super-utilizers account for many emergency department visits (EDV) and hospitalizations. Among Medicare/Medicaid patients, 5% to 10% account for >50% of spending. Little is known about super-utilization in gynecologic oncology. Charts of 64 gynecologic oncology patients with ≥3 EDV and/or admissions over 12 months were reviewed retrospectively. Cancer type distribution was 47% ovarian, 23% cervical, 23% endometrial, and 6% vulvar. Treatment at index visit was 61% chemotherapy, 16% no treatment, 8% recent surgery, and 6% radiation...
February 1, 2018: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
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