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https://www.readbyqxmd.com/read/29906501/repurposing-drugs-as-inhaled-therapies-in-asthma
#1
Sandra D Anderson
For the first 40 years of the 20th century treatment for asthma occurred in response to an asthma attack. The treatments were given by injection or orally and included the adrenergic agonists adrenalin/epinephrine and ephedrine and a phosphodiesterase inhibitor theophylline. Epinephrine became available as an aerosol in 1930. After 1945, isoprenaline, a non-selective beta agonist, became available for oral use but it was most widely used by inhalation. Isoprenaline was short-acting with unwanted cardiac effects...
June 12, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29892141/delayed-complications-and-long-term-management-of-sulfur-mustard-poisoning-a-narrative-review-of-recent-advances-by-iranian-researchers-part-%C3%B0-%C3%B0-clinical-management-and-therapy
#2
REVIEW
Leila Etemad, Mohammad Moshiri, Mahdi Balali-Mood
The present study aimed to review and discuss the recommended and recently suggested protocols by Iranian researchers for a long-term treatment of delayed complications of sulfur mustard (DCSM) in veterans. As indicated clinically, patients who suffer from delayed ocular complications of sulfur mustard (DOCS) benefit from treatments for dry eyes, therapeutic contact lenses, amniotic membrane transplantation; blepharorrhaphy, tarsorrhaphy, limbal stem cell transplantation; corneal transplantation, topical steroids, and immunosuppressive...
May 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29861841/long-term-exposure-to-low-dose-haemophilus-influenzae-during-allergic-airway-disease-drives-a-steroid-resistant-neutrophilic-inflammation-and-promotes-airway-remodeling
#3
Xu Yang, Yijie Wang, Shengtao Zhao, Ran Wang, Changzheng Wang
Growing evidences indicate that bacteria are associated with pathogenesis of neutrophilic asthma. However, the long-term effect of airway bacterial colonization remains unclear. We sought to establish a murine model to simulate the airway inflammation of long-term bacterial colonization, and to assess the effects of bacteria on allergic airway disease (AAD). BALB/c mice were sensitized twice and subsequently challenged with ovalbumin (OVA) and exposed to low-dose Haemophilus influenzae for approximately 2 months...
May 18, 2018: Oncotarget
https://www.readbyqxmd.com/read/29852508/clinical-outcomes-among-diagnostic-subgroups-of-infants-with-severe-bronchopulmonary-dysplasia-through-2-years-of-age
#4
Gangaram Akangire, Winston Manimtim, Michael F Nyp, Janelle Noel-MacDonnell, Allyssa N Kays, William E Truog, Jane B Taylor
OBJECTIVE:  This article aimed to identify readmission risk factors through 2 years of life for infants with severe bronchopulmonary dysplasia (BPD) who do not require tracheostomy and ventilatory support after neonatal intensive care unit (NICU) discharge. It also aimed to identify if clinical differences exist between the subcategories of severe BPD. STUDY DESIGN:  A retrospective chart review was performed on 182 infants with severe BPD born between 2010 and 2015...
May 31, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29849453/short-term-effect-of-a-smart-nebulizing-device-on-adherence-to-inhaled-corticosteroid-therapy-in-asthma-predictive-index-positive-wheezing-children
#5
Yuan Zhou, Yanming Lu, Haojin Zhu, Yanhan Zhang, Yaqin Li, Qing Yu
Objective: To explore the effect of a smart nebulizing device on the rate of adherence to inhaled corticosteroid (ICS) in children with positive Asthma Predictive Index. Methods: In total, 65 children with positive Asthma Predictive Index and under the age of 5 years who visited our hospital from October 2015 through October 2016, were randomly assigned to receive conventional nebulization or smart nebulization. The smart nebulizer was connected to smart phones via an App...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29794744/post-radiotherapy-maintenance-treatment-with-fluticasone-propionate-and-salmeterol-for-lung-cancer-patients-with-grade-iii-radiation-pneumonitis-a-case-report
#6
Pingping Zhang, Hongxia Yan, Sheng Wang, Jindan Kai, Guoliang Pi, Yi Peng, Xiyou Liu, Junwei Sun
RATIONALE: This combination of fluticasone propionate (FP) and the long-acting β2-agonist salmeterol (Salm) can control the symptoms of asthma and COPD better than FP or Salm on their own and better than the combination of inhaled corticosteroids plus montelukast. FP/Salm has been shown to control symptoms of asthma and COPD better than a double dose of inhaled steroids. The patient in our report had a history of COPD, and suffered relapse of RP when given only steroids. It is possible that COPD history helps explain this patient's more difficult treatment course...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29747661/modelling-the-asthma-phenotype-impact-of-cigarette-smoke-exposure
#7
Maria G Belvisi, Katie Baker, Nicole Malloy, Kristof Raemdonck, Bilel Dekkak, Michael Pieper, Anthony T Nials, Mark A Birrell
BACKGROUND: Asthmatics that are exposed to inhaled pollutants such as cigarette smoke (CS) have increased symptom severity. Approximately 25% of adult asthmatics are thought to be active smokers and many sufferers, especially in the third world, are exposed to high levels of inhaled pollutants. The mechanism by which CS or other airborne pollutants alter the disease phenotype and the effectiveness of treatment in asthma is not known. The aim of this study was to determine the impact of CS exposure on the phenotype and treatment sensitivity of rodent models of allergic asthma...
May 10, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29743787/acute-lung-injury-after-exposure-to-fumes-of-pickling-paste-in-a-fabrication-worker
#8
S Bavikar Purva, K Dattarai More
Pickling paste is used for cleaning stainless steel weld seam heat marks. It is a mixture of hydrofluoric acid (HF) and nitric acid (HNO3 ) with surfactants and inhibitors. The substance is corrosive, toxic, and irritant. Air respirator and half mask air filter covering nose and mouth are mandatory before handling the pickling paste. This is a case report of a 28-year-old male complaining of sudden onset dyspnea at rest after accidental inhalation of pickling paste fumes. The patient developed acute lung injury and subsequently acute respiratory distress syndrome and was treated with noninvasive ventilation, steroids, and other supportive treatment...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29738253/glycerol-solvates-dppc-headgroups-and-localises-in-the-interfacial-regions-of-model-pulmonary-interfaces-altering-bilayer-structure
#9
Wachirun Terakosolphan, Jemma L Trick, Paul G Royall, Sarah E Rogers, Olimpia Lamberti, Christian D Lorenz, Ben Forbes, Richard D Harvey
The inclusion of glycerol in formulations for pulmonary drug delivery may affect the bioavailability of inhaled steroids by retarding their transport across the lung epithelium. The aim of this study was to evaluate whether the molecular interactions of glycerol with model pulmonary interfaces provide a biophysical basis for glycerol modifying inhaled drug transport. Dipalmitoylphosphatidylcholine (DPPC) monolayers and liposomes were used as model pulmonary interfaces, in order to examine the effects of bulk glycerol (0 - 30% w/w) on their structures and dynamics using complementary biophysical measurements and molecular dynamics (MD) simulations...
May 8, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29734948/inhaled-corticosteroids-in-ventilated-preterm-neonates-a-non-randomized-dose-ranging-study
#10
Kamini Raghuram, Michael Dunn, Krista Jangaard, Maureen Reilly, Elizabeth Asztalos, Edmond Kelly, Michael Vincer, Vibhuti Shah
BACKGROUND: Inhaled corticosteroids (ICS) offer targeted treatment for bronchopulmonary dysplasia (BPD) with minimal systemic effects compared to systemic steroids. However, dosing of ICS in the management of infants at high-risk of developing BPD is not well established. The objective of this study was to determine an effective dose of ICS for the treatment of ventilator-dependent infants to facilitate extubation or reduce fractional inspired oxygen concentration. METHODS: Forty-one infants born at < 32 weeks gestational age (GA) or < 1250 g who were ventilator-dependent at 10-28 days postnatal age were included...
May 7, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29733738/case-study-a-combination-of-mepolizumab-and-omaluzimab-injections-for-severe-asthma
#11
Rejmon Dedaj, Lindie Unsel
A Combination of Mepolizumab and Omaluzimab injections for severe asthma. INTRODUCTION: Patients with severe persistent asthma account for a large proportion of asthma morbidity and health care expenditures. In this case report we describe the use of a combination of omalizumab and mepolizumab in severe asthma with elevated IgE levels and eosinophilic phenotype. CASE STUDY: We are treating a 55 year old woman with severe persistent eosinophilic asthma and elevated IgE levels...
May 7, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29728933/effect-of-topical-steroids-on-skin-prick-test-a-randomized-controlled-trial
#12
Anne R Ebbesen, Lene A Riis, Josefine Gradman
INTRODUCTION: Topically applied corticosteroids on the skin can significantly inhibit the wheal response to allergens in skin prick test (SPT). The duration of this effect is unknown. The aim of this study is to investigate the duration of the inhibitory effect of topical corticosteroids on SPT. METHODS: Twenty-two healthy subjects were included in a single-blinded randomized study. All subjects were skin prick tested using a standard inhalant allergen panel. The subjects were randomized to treat either the left or right forearm with Betnovat® cream (group III steroid) once a day for 10 days...
May 4, 2018: Dermatology and Therapy
https://www.readbyqxmd.com/read/29724960/cluster-analysis-on-breath-print-of-newly-diagnosed-copd-patients-effects-of-therapy
#13
Simone Scarlata, Panaiotis Finamore, Simona Santangelo, Gilda Giannunzio, Giorgio Pennazza, Simone Grasso, Marco Santonico, Raffaele Antonelli Incalzi
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease and airflow limitation and symptoms only partially capture such heterogeneity. Since COPD is known to affect the production of volatile organic compounds (VOCs), we aimed at verifying to which extent exhaled VOCs can characterize newly diagnosed COPD patients and changes in response to inhaled therapy.&#13; Materials and methods: Fifty newly diagnosed COPD patients were consecutively recruited among those attending the pulmonary medicine outpatient clinic at "Campus Bio-Medico" University Hospital...
May 4, 2018: Journal of Breath Research
https://www.readbyqxmd.com/read/29704475/chronic-cough-related-to-acute-viral-bronchiolitis-in-children-chest-expert-panel-report
#14
Anne B Chang, John J Oppenheimer, Bruce K Rubin, Miles Weinberger, Richard S Irwin
BACKGROUND: Acute bronchiolitis is common in young children and some children develop chronic cough after their bronchiolitis. We thus undertook systematic reviews based on key questions (KQs) using the PICO format. The KQs were: Among children with chronic cough (>4 weeks) after acute viral bronchiolitis, how effective are the following interventions in improving the resolution of cough?: (1) Antibiotics. If so what type and for how long? (2) Asthma medications (inhaled steroids, beta2 agonist, montelukast) and; (3) Inhaled osmotic agents like hypertonic saline? METHODS: We used the CHEST expert cough panel's protocol and the American College of Chest Physicians (CHEST) methodological guidelines and GRADE framework...
April 25, 2018: Chest
https://www.readbyqxmd.com/read/29702974/case-report-of-the-successful-treatment-of-lung-injury-caused-by-occupational-exposure-to-methyl-chloroformate-and-literature-review
#15
Jiayi Zhao, Rong Chai, Yiping Han, Jing Sheng, Chong Bai, Haidong Huang
BACKGROUND: The treatment of acute lung injuries caused by the inhalation of methyl chloroformate remains a difficult clinical problem, with a poor prognosis and a high mortality. CASE PRESENTATION: After inhalation injuries from methyl chloroformate poisoning, bronchoscopy plays an important role in the diagnosis and treatment of patients. A low tidal air volume and earlier application of steroids are also essential for successful treatment. The grading of acute exposure guideline levels (AEGLs) can direct the selection of a therapeutic regimen for patients with methyl chloroformate poisoning...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29699879/treatment-of-post-intubation-laryngeal-granulomas-systematic-review-and-proportional-meta-analysis
#16
Caroline Fernandes Rimoli, Regina Helena Garcia Martins, Daniele Cristina Catâneo, Rui Imamura, Antonio José Maria Catâneo
INTRODUCTION: Laryngeal granulomas post intubation are benign but recurrent lesions. There is no consensus for its treatment. OBJECTIVE: To describe the effectiveness of different treatment modalities for primary or recurrent laryngeal granulomas resulting from endotracheal intubation. METHODS: Systematic review and proportional meta-analysis. Eligibility criteria - experimental or observational studies with at least five subjects. Outcomes studied - granuloma resolution, recurrence, and time for resolution...
April 14, 2018: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29696728/predictive-value-of-eosinophils-and-neutrophils-on-clinical-effects-of-ics-in-copd
#17
Floor J Hartjes, Judith M Vonk, Alen Faiz, Pieter S Hiemstra, Thérèse S Lapperre, Huib A M Kerstjens, Dirkje S Postma, Maarten van den Berge
BACKGROUND AND OBJECTIVE: Inflammation is present to a variable degree and composition in patients with COPD. This study investigates associations between both eosinophils and neutrophils in blood, sputum, airway wall biopsies and bronchoalveolar lavage (BAL) and their potential use as biomarkers for clinical response to inhaled corticosteroids (ICS). METHODS: In total, 114 steroid-naïve COPD patients of the Groningen Leiden Universities Corticosteroids in Obstructive Lung Disease (GLUCOLD) study using ICS or placebo during 30-month follow-up were included...
April 26, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29688849/cryptococcoma-of-a-transplanted-kidney-in-a-patient-presenting-with-recurrent-urinary-tract-infection-a-case-report
#18
Albert Z Muranda, Ludolf Greeff, Mike M Sathekge, Thabo Lengano, Victor O L Karusseit
BACKGROUND: Cryptococcosis is an important opportunistic infection of organ transplant recipients. It is the third most common fungal infection of transplant patients and occurs especially in kidney recipients. Cryptococcus neoformans is a ubiquitous fungus which infects humans by inhalation of spores. C. gattii has more recently been recognised as a pathogen. Infection commonly is disseminated affecting mainly the central nervous system and the lungs. Cryptococcoma, a localised form of the disease, has been described in various organs...
April 23, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29672188/effect-of-inhaled-corticosteroid-use-on-weight-bmi-in-pediatric-patients-with-moderate-severe-asthma
#19
Jennifer Han, John Nguyen, Yuna Kim, Bob Geng, Gale Romanowski, Lawrence Alejandro, James Proudfoot, Ronghui Xu, Sydney Leibel
OBJECTIVES: Assess the relationship between inhaled corticosteroid use (ICS) and weight (BMI) in pediatric patients with moderate-severe asthma. Assess if the number of emergency department (ED) visits correlates with overall BMI trajectory. Assess the trend of prescribing biologic therapy in pediatric patients with moderate-severe asthma and determine its relationship with weight (BMI). METHODS: A retrospective chart review was performed on 93 pediatric patients with moderate-severe asthma to determine the relationship between ICS use and weight (BMI), biologic therapy and BMI, and number of ED visits and BMI trajectory...
April 19, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29671509/combination-laba-inhalers-compared-with-high-dose-inhaled-steroids-for-adults-with-asthma
#20
Andrew Aherne, John Kilpatrick
No abstract text is available yet for this article.
March 1, 2018: American Family Physician
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