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https://www.readbyqxmd.com/read/29232717/the-relationship-of-depression-in-asthma-chronic-obstructive-pulmonary-disease-overlap-syndrome
#1
Jun-Jun Yeh, Cheng-Li Lin, Wu-Huei Hsu, Chia-Hung Kao
PURPOSE: To clarify the relationship between asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS) and depression. METHODS: We identified 10,911 patients who received an ACOS diagnosis and concurrent treatment between January 2000 and December 2009. Subjects without ACOS were included in the non-ACOS cohort (n = 10,911). Cox proportional hazard regression analysis was performed to compare the risk of depression between the ACOS and non-ACOS cohorts...
2017: PloS One
https://www.readbyqxmd.com/read/29227043/the-association-of-air-pollutants-and-allergic-and-nonallergic-rhinitis-in-chronic-rhinosinusitis
#2
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas M Kaffenberger, Thomas J Willson, Stella E Lee
BACKGROUND: There has been little investigation regarding air quality and rhinitis in the pathophysiology of upper airway disease. In this study, we assessed the impact of inhalant pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on allergic rhinitis and chronic rhinosinusitis (CRS) disease severity. METHODS: CRS patients with nasal polyps (CRSwNP) and without polyps (CRSsNP) were identified. Spatial modeling from pollutant monitoring sites was used to estimate exposures for patients meeting the inclusion criteria (total, n = 125; CRSsNP, n = 67; CRSsNP, n = 58)...
December 11, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29224252/are-inhaled-steroids-safe-and-effective-for-prevention-or-treatment-of-bronchopulmonary-dysplasia
#3
Eric S Shinwell
Bronchopulmonary Dysplasia (BPD) represents a major threat to the short and long-term health and development of very preterm infants. Unfortunately, despite much study and progress in neonatology in recent years and some modest improvements in survival, both the incidence and severity of BPD remain frustratingly stable (1). This article is protected by copyright. All rights reserved.
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29213023/-tracheobronchitis-as-an-extraintestinal-manifestation-of-crohn-s-disease
#4
Ryosuke Sakemi, Suketo So, Yosuke Morimitsu, Tetsuhiro Noda, Kensei Ohtsu, Yoshihiko Karashima, Kentaro Imamura, Hiroya Terabe, Yasuo Chojin, Tatsuji Kato
A 27-year-old woman with Crohn's disease, who had sustained clinical remission for two years following treatment with mesalazine and nutrition therapy, was admitted to our hospital complaining of dry cough, mild dysphagia, and slight fever. A computed tomography of the chest demonstrated an increase in the thickness of the tracheal wall. Bronchoscopy showed a diffusely erythematous and edematous mucosa with whitish granular lesions in the trachea and main carina. Bronchial biopsy specimens showed epithelioid cell granuloma...
2017: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29210888/pneumonia-in-a-teenager-hiding-a-fire-eating-stunt
#5
Michele Ghezzi, Marta Odoni, Oriana Testagrossa, Daniela Messina, Jorge Daniel Ruocco, Camillo Lovati, Ahmad Kantar
Pneumonia in children due to hydrocarbon aspiration is usually the result of an uncommon accidental event. However, an acute and severe type of pneumonia induced by hydrocarbon aspiration is occasionally experienced by entertainers known as fire-eaters. Different approaches to treat fire-eater's pneumonia appear in the literature. Although there is no consensus regarding the management of this condition, the use of antibiotic therapy is well recognized and recommended by some, whereas others recommend only supportive treatment...
November 27, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29210519/air-pollutants-may-be-environmental-risk-factors-in-chronic-rhinosinusitis-disease-progression
#6
Leila J Mady, Hannah L Schwarzbach, John A Moore, Robert M Boudreau, Thomas J Willson, Stella E Lee
BACKGROUND: Little is known about the role of environmental exposures in the pathophysiology of chronic rhinosinusitis (CRS). In this study, we measured the impact of air pollutants (particulate matter 2.5 [PM2.5 ] and black carbon [BC]) on CRS with nasal polyposis (CRSwNP) and CRS without nasal polyposis (CRSsNP). METHODS: Spatial modeling from pollutant monitoring sites was used to estimate exposures surrounding residences for patients meeting inclusion criteria (total patients, n = 234; CRSsNP, n = 96; CRSwNP, n = 138)...
December 6, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29206057/school-nurse-asthma-program-reduces-healthcare-utilization-in-children-with-persistent-asthma
#7
Michelle Trivedi, Janki Patel, Darleen Lessard, Ted Kremer, Nancy Byatt, Wanda Phipatanakul, Lori Pbert, Robert Goldberg
OBJECTIVE: We examined the impact of a novel, school nurse-supervised asthma therapy program on healthcare utilization. METHODS: We retrospectively reviewed charts of 84 children enrolled in this program in central Massachusetts between 2012 and 2015. Physicians identified children with persistent asthma and poor medication adherence. These children were enrolled in the program to receive daily-inhaled corticosteroid at school, supervised by their school nurse, with ongoing communication between physician's office and school nurse through the school year...
December 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29197890/siphoning-diesel-a-fatal-mistake
#8
W C Leong, B M Cheong
Diesel is commonly used as fuel for engines and is distilled from petroleum. Diesel has toxic potential and can affect multiple organs. Exposure can occur after ingestion, inhalation or through the dermal route. The practice of siphoning diesel using a rubber tubing and the mouth is common in rural communities. This can lead to accidental ingestion and aspiration. Here we report a case of a patient who accidentally ingested diesel during siphoning, which caused extensive erosion of the oral cavity and oesophagus leading to pneumomediastinum and severe chemical lung injury...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29190796/risk-factors-for-the-development-of-chronic-pulmonary-aspergillosis-in-patients-with-nontuberculous-mycobacterial-lung-disease
#9
Byung Woo Jhun, Woo Jin Jung, Na Young Hwang, Hye Yun Park, Kyeongman Jeon, Eun-Suk Kang, Won-Jung Koh
Nontuberculous mycobacterial lung disease (NTM-LD) is increasingly recognized as an important predisposing condition for the development of chronic pulmonary aspergillosis (CPA), but there are limited data on the risk factors for CPA development in NTM-LD patients. We reviewed the medical records of 566 patients who, at the time of diagnosis of NTM-LD, did not have CPA and who received ≥12 months of treatment for NTM-LD between January 2010 and June 2015. Of these patients, 41 (7.2%) developed CPA (NTM-CPA group), whereas the remaining 525 patients did not develop CPA (NTM group)...
2017: PloS One
https://www.readbyqxmd.com/read/29184823/a-prospective-randomized-controlled-study-theophylline-on-oxidative-stress-and-steroid-sensitivity-in-chronic-obstructive-pulmonary-disease-patients
#10
R Ranjani, A T Sathiya Vinotha
Objective: Oxidative stress is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). Corticosteroid fails to suppress inflammation and oxidative stress due to steroid resistance. Theophylline has an effect on histone deacetylase (HDAC) activity and improves steroid sensitivity in COPD. Given changes in oxidative stress associated with diminished corticosteroid effects, a clinical study in which antioxidants and free radicals are estimated can suggest a correlation between antioxidants, theophylline, and corticosteroid sensitivity...
July 2017: International Journal of Pharmaceutical Investigation
https://www.readbyqxmd.com/read/29182799/inhaled-magnesium-sulfate-in-the-treatment-of-acute-asthma
#11
REVIEW
Rachel Knightly, Stephen J Milan, Rodney Hughes, Jennifer A Knopp-Sihota, Brian H Rowe, Rebecca Normansell, Colin Powell
BACKGROUND: Asthma exacerbations can be frequent and range in severity from mild to life-threatening. The use of magnesium sulfate (MgSO₄) is one of numerous treatment options available during acute exacerbations. While the efficacy of intravenous MgSO₄ has been demonstrated, the role of inhaled MgSO₄ is less clear. OBJECTIVES: To determine the efficacy and safety of inhaled MgSO₄ administered in acute asthma. SPECIFIC AIMS: to quantify the effects of inhaled MgSO₄ I) in addition to combination treatment with inhaled β₂-agonist and ipratropium bromide; ii) in addition to inhaled β₂-agonist; and iii) in comparison to inhaled β₂-agonist...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29160160/ideal-particle-sizes-for-inhaled-steroids-targeting-vocal-granulomas-preliminary-study-using-computational-fluid-dynamics
#12
Elizabeth L Perkins, Saikat Basu, Guilherme J M Garcia, Robert A Buckmire, Rupali N Shah, Julia S Kimbell
Objectives Vocal fold granulomas are benign lesions of the larynx commonly caused by gastroesophageal reflux, intubation, and phonotrauma. Current medical therapy includes inhaled corticosteroids to target inflammation that leads to granuloma formation. Particle sizes of commonly prescribed inhalers range over 1 to 4 µm. The study objective was to use computational fluid dynamics to investigate deposition patterns over a range of particle sizes of inhaled corticosteroids targeting the larynx and vocal fold granulomas...
November 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29158824/dioscin-exerts-protective-effects-against-crystalline-silica-induced-pulmonary-fibrosis-in-mice
#13
Chao Li, Yiping Lu, Sitong Du, Siyi Li, Yiting Zhang, Fangwei Liu, Ying Chen, Dong Weng, Jie Chen
Inhalation of crystalline silica particles leads to pulmonary fibrosis, eventually resulting in respiratory failure and death. There are few effective drugs that can delay the progression of this disease; thus, patients with silicosis are usually only offered supportive care. Dioscin, a steroidal saponin, exhibits many biological activities and health benefits including its protective effects against hepatic fibrosis. However, the effect of dioscin on silicosis is unknown. METHODS: We employed experimental mouse mode of silicosis...
2017: Theranostics
https://www.readbyqxmd.com/read/29156455/-the-overrated-impact-of-inhaled-substances-laba-lama-ics-on-exacerbation-rates-in-copd
#14
D Köhler, D Dellweg
Numerous studies have shown that exacerbation rates in COPD can be significantly reduced by long acting beta-2-agonists (LABA), long acting anticholinergic agents (LAMA) and inhaled steroids (ICS). Elaborate and extensive investigations however failed to prove that the reduction in exacerbation rates leads to life prolongation. As opposed to this, numerous studies have shown a reduction in life expectancy with increasing number and severity of exacerbations.This review aimed at comparing these studies and to elaborate the relevance and reduction of exacerbations rates by LABA, LAMA and ICS application through effect size calculation by means of Cohens' d...
November 20, 2017: Pneumologie
https://www.readbyqxmd.com/read/29151314/effect-of-inhaled-steroids-on-clinical-and-inflammatoryparameters-in-children-with-cystic-fibrosis
#15
Zeynep Seda Uyan, Göksenin Ünlügüzel Üstün, Goncagül Haklar, Erkan Çakır, Sedat Oktem, Refika Ersu, Bülent Taner Karadağ, Fazilet Karakoç, Elif Dağlı
Background/aim: The effectiveness of inhaled corticosteroids (ICSs) in cystic fibrosis (CF) is controversial. The aim of this study was to investigate the effect of an ICS on bronchial hyperreactivity (BHR), oxidative status, and clinical and inflammatory parameters in CF patients. Materials and methods: CF patients were randomized to receive either 2 mg/day nebulized budesonide or 0.9% normal saline as placebo for 8 weeks. Results: Twenty-nine CF patients (mean age: 10.5 ± 2.9 years) were enrolled in the study...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29130803/steroid-sparing-effect-of-sublingual-immunotherapy-real-life-study-in-mono-polisensitized-children-with-asthma
#16
Nerin Nadir Bahceciler, Nilufer Galip, Arzu Babayigit
AIM: Steroid-sparing effect of sublingual immunotherapy (SLIT) in mono/polisensitized asthmatic children were evaluated. MATERIALS AND METHODS:  Children undergoing allergen-specific SLIT between 2010 and 2014 were included. Asthma control and usage/dose of inhaled corticosteroid (ICS) in the previous year was determined. Asthma control without ICS need ≥6 months was defined as 'ICS avoidance'. RESULTS:  90 children (mean ± SD age 8...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29124506/heart-rate-variability-biofeedback-does-not-substitute-for-asthma-steroid-controller-medication
#17
Paul M Lehrer, Charles G Irvin, Shou-En Lu, Anthony Scardella, Beatrix Roehmheld-Hamm, Milisyaris Aviles-Velez, Jessica Graves, Evgeny G Vaschillo, Bronya Vaschillo, Flavia Hoyte, Harold Nelson, Frederick S Wamboldt
Despite previous findings of therapeutic effects for heart rate variability biofeedback (HRVB) on asthma, it is not known whether HRVB can substitute either for controller or rescue medication, or whether it affects airway inflammation. Sixty-eight paid volunteer steroid naïve study participants with mild or moderate asthma were given 3 months of HRVB or a comparison condition consisting of EEG alpha biofeedback with relaxing music and relaxed paced breathing (EEG+), in a two-center trial. All participants received a month of intensive asthma education prior to randomization...
November 9, 2017: Applied Psychophysiology and Biofeedback
https://www.readbyqxmd.com/read/29121247/prediction-of-individual-outcomes-for-asthma-sufferers
#18
B Storlie Curtis, E Branda Megan, R Gionfriddo Michael, D Shah Nilay, A Rank Matthew
We consider the problem of individual-specific medication level recommendation (initiation, removal, increase, or decrease) for asthma sufferers. Asthma is one of the most common chronic diseases in both adults and children, affecting 8% of the US population and costing $37-63 billion/year in the United States of America. Asthma is a complex disease, whose symptoms may wax and wane, making it difficult for clinicians to predict outcomes and prognosis. Improved ability to predict prognosis can inform decision making and may promote conversations between clinician and provider around optimizing medication therapy...
November 6, 2017: Biostatistics
https://www.readbyqxmd.com/read/29112905/determinants-of-hair-cortisol-concentration-in-children-a-systematic-review
#19
REVIEW
N A Gray, A Dhana, L Van Der Vyver, J Van Wyk, N P Khumalo, D J Stein
BACKGROUND: Several factors are known contribute to hair cortisol concentration (HCC) in adults. However, there is less research on determinants of HCC in children and adolescents. HCC is a valuable tool for medical research pertaining to the hypothalamic-pituitary-adrenal (HPA) axis. This review aims to assess the extent to which established determinants of HCC in adults have been consistently reported in children (birth - 18 years) and to identify determinants of HCC specific to this age group...
November 2, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29108449/iatrogenic-cushing-syndrome-in-a-47-year-old-hiv-positive-woman-on-ritonavir-and-inhaled-budesonide
#20
Lily Colpitts, Thomas B Murray, Sami G Tahhan, Jody P Boggs
Iatrogenic Cushing syndrome (CS) is a well-known complication of treating patients with systemic steroids. More rarely, it has been described in HIV-positive patients on ritonavir (RTV) while using the inhaled corticosteroid fluticasone, which is metabolized through the cytochrome P450 3A4 (CYP3A4) enzyme system. In the presence of RTV, a known CYP3A4 enzyme inhibitor, the interaction can result in impaired metabolism and systemic accumulation of inhaled fluticasone resulting in iatrogenic CS. Iatrogenic CS has been less often described with inhaled budesonide compared to inhaled fluticasone...
January 1, 2017: Journal of the International Association of Providers of AIDS Care
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