keyword
MENU ▼
Read by QxMD icon Read
search

Propionyl carnitine

keyword
https://www.readbyqxmd.com/read/27836788/regression-of-fibrosis-cirrhosis-by-glycine-propionyl-l-carnitine-treatment-in-d-galactosamine-induced-chronic-liver-damage
#1
Ajaz Ahmad Ganai, Ishfaq Ahmad Ganaie, Nishika Verma, Humaira Farooqi
BACKGROUND AND PURPOSE: Liver fibrosis and cirrhosis are leading causes of morbidity and mortality, with majority of preventable cases attributed to excessive alcohol consumption, viral hepatitis, or non-alcoholic fatty liver disease. We previously reported the hepatoprotective effect of Glycine propionyl-l-carnitine (GPLC) against the fulminant hepatic failure (FHF) induced by d-Galactosamine (D-GalN). In this study we evaluated the protective effect of GPLC against D-GalN induced chronic liver damage...
November 9, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27771504/changes-in-the-levels-of-l-carnitine-acetyl-l-carnitine-and-propionyl-l-carnitine-are-involved-in-perfluorooctanoic-acid-induced-developmental-cardiotoxicity-in-chicken-embryo
#2
Qixiao Jiang, Chunbo Wang, Chan Xue, Lingfang Xue, Meiting Wang, Changhao Li, Ziwen Deng, Qian Wang
Perfluorooctanoic acid (PFOA), a persistent organic pollutant, is associated with developmental toxicity. This study investigated the mechanism of PFOA-induced developmental cardiotoxicity in chicken embryo, focusing on the interactions between developmental exposure to PFOA and the levels of l-carnitine (LC), acetyl-l-carnitine (ALC) and propionyl-l-carnitine (PLC) in the heart. To evaluate the developmental cardiotoxicity, fertile chicken eggs were exposed to 0.1, 0.5, 1, 2 or 5mg/kg PFOA via air cell injection...
December 2016: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/27670840/improvement-in-the-prognosis-and-development-of-patients-with-methylmalonic-acidemia-after-living-donor-liver-transplant
#3
Rieko Sakamoto, Kimitoshi Nakamura, Jun Kido, Shiro Matsumoto, Hiroshi Mitsubuchi, Yukihiro Inomata, Fumio Endo
Liver transplant is a treatment option for patients with MMA-emia. While this therapy does not bring about a complete cure, it is expected to prolong survival and improve the QOL of patients. The aim of this study was to evaluate the significance of LDLT for patients with MMA-emia in Japan. Clinical information on 13 patients with MMA-emia who underwent LDLT was acquired using a self-developed questionnaire sent to the doctors who provided medical care to patients with MMA-emia after LDLT. Almost all of the patients continued on a protein-restricted diet, and the number of acidosis attacks had significantly decreased...
September 26, 2016: Pediatric Transplantation
https://www.readbyqxmd.com/read/27057307/metabolomics-studies-identify-novel-diagnostic-and-prognostic-indicators-in-patients-with-alcoholic-hepatitis
#4
Mona Ascha, Zeneng Wang, Mustafa S Ascha, Raed Dweik, Nizar N Zein, David Grove, J Mark Brown, Stephanie Marshall, Rocio Lopez, Ibrahim A Hanouneh
AIM: To identify plasma analytes using metabolomics that correlate with the diagnosis and severity of liver disease in patients with alcoholic hepatitis (AH). METHODS: We prospectively recruited patients with cirrhosis from AH (n = 23) and those with cirrhosis with acute decompensation (AD) from etiologies other than alcohol (n = 25). We used mass spectrometry to identify 29 metabolic compounds in plasma samples from fasted subjects. A receiver operating characteristics analysis was performed to assess the utility of biomarkers in distinguishing acute AH from alcoholic cirrhosis...
April 8, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/26913383/low-levels-of-short-and-medium-chain-acylcarnitines-in-hiv-infected-patients
#5
Bjørn Waagsbø, Asbjørn Svardal, Thor Ueland, Linn Landrø, Olav Øktedalen, Rolf K Berge, Trude H Flo, Pål Aukrust, Jan K Damås
BACKGROUND: Carnitine plays an essential role in fatty acid metabolism, exerts substantial antioxidant action and regulates immune functions. We hypothesized that a disturbed carnitine metabolism could be involved in progression of HIV infection. MATERIALS AND METHODS: Plasma levels of L-carnitine, its precursors, and short-, medium- and long-chain acylcarnitines were analysed with HPLC/mass spectrometry in HIV-infected patients with various disease severities including patients who acquired Mycobacterium avium complex (MAC) infection...
May 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26585821/antioxidants-and-vascular-health
#6
REVIEW
Alessandra Bielli, Maria Giovanna Scioli, Donatella Mazzaglia, Elena Doldo, Augusto Orlandi
Oxygen free radicals and other reactive oxygen species (ROS) are common products of normal aerobic cellular metabolism, but high levels of ROS lead to oxidative stress and cellular damage. Increased production of ROS favors vascular dysfunction, inducing altered vascular permeability and inflammation, accompanied by the loss of vascular modulatory function, the imbalance between vasorelaxation and vasoconstriction, and the aberrant expression of inflammatory adhesion molecules. Inflammatory stimuli promote oxidative stress generated from the increased activity of mitochondrial nicotinamide adenine dinucleotide phosphate oxidase, particularly of the Nox4 isoform, with the consequent impairment of mitochondrial β-oxidation...
December 15, 2015: Life Sciences
https://www.readbyqxmd.com/read/26497755/altered-metabolic-profile-with-sodium-restricted-dietary-approaches-to-stop-hypertension-diet-in-hypertensive-heart-failure-with-preserved-ejection-fraction
#7
Anna V Mathew, E Mitchell Seymour, Jaeman Byun, Subramaniam Pennathur, Scott L Hummel
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is increasingly recognized as a distinct entity with unique pathophysiology. In the Dietary Approaches to Stop Hypertension in Diastolic Heart Failure (DASH-DHF) study, the sodium-restricted Dietary Approaches to Stop Hypertension diet (DASH/SRD) was associated with improved blood pressure and cardiovascular function in 13 hypertensive patients with HFpEF. With the use of targeted metabolomics, we explored metabolite changes and their relationship with energy-dependent measures of cardiac function in DASH-DHF...
December 2015: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/26473356/propionyl-l-carnitine-enhances-wound-healing-and-counteracts-microvascular-endothelial-cell-dysfunction
#8
Maria Giovanna Scioli, Pietro Lo Giudice, Alessandra Bielli, Valeria Tarallo, Alfonso De Rosa, Sandro De Falco, Augusto Orlandi
BACKGROUND: Impaired wound healing represents a high cost for health care systems. Endothelial dysfunction characterizes dermal microangiopathy and contributes to delayed wound healing and chronic ulcers. Endothelial dysfunction impairs cutaneous microvascular blood flow by inducing an imbalance between vasorelaxation and vasoconstriction as a consequence of reduced nitric oxide (NO) production and the increase of oxidative stress and inflammation. Propionyl-L-carnitine (PLC) is a natural derivative of carnitine that has been reported to ameliorate post-ischemic blood flow recovery...
2015: PloS One
https://www.readbyqxmd.com/read/26433381/modification-of-astrocyte-metabolism-as-an-approach-to-the-treatment-of-epilepsy-triheptanoin-and-acetyl-l-carnitine
#9
Mussie Ghezu Hadera, Tanya McDonald, Olav B Smeland, Tore W Meisingset, Haytham Eloqayli, Saied Jaradat, Karin Borges, Ursula Sonnewald
Epilepsy is a severe neurological disorder characterized by altered electrical activity in the brain. Important pathophysiological mechanisms include disturbed metabolism and homeostasis of major excitatory and inhibitory neurotransmitters, glutamate and GABA. Current drug treatments are largely aimed at decreasing neuronal excitability and thereby preventing the occurrence of seizures. However, many patients are refractory to treatment and side effects are frequent. Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy in adults...
February 2016: Neurochemical Research
https://www.readbyqxmd.com/read/26357785/attenuating-the-systemic-inflammatory-response-to-adult-cardiopulmonary-bypass-a-critical-review-of-the-evidence-base
#10
REVIEW
R Clive Landis, Jeremiah R Brown, David Fitzgerald, Donald S Likosky, Linda Shore-Lesserson, Robert A Baker, John W Hammon
A wide range of pharmacological, surgical, and mechanical pump approaches have been studied to attenuate the systemic inflammatory response to cardiopulmonary bypass, yet no systematically based review exists to cover the scope of anti-inflammatory interventions deployed. We therefore conducted an evidence-based review to capture "self-identified" anti-inflammatory interventions among adult cardiopulmonary bypass procedures. To be included, trials had to measure at least one inflammatory mediator and one clinical outcome, specified in the "Outcomes 2010" consensus statement...
September 2014: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/26343941/biotin-deprivation-impairs-mitochondrial-structure-and-function-and-has-implications-for-inherited-metabolic-disorders
#11
Estefanía Ochoa-Ruiz, Rodrigo Díaz-Ruiz, Alaín de J Hernández-Vázquez, Isabel Ibarra-González, Alma Ortiz-Plata, Daniel Rembao, Daniel Ortega-Cuéllar, Benoit Viollet, Salvador Uribe-Carvajal, José Ahmed Corella, Antonio Velázquez-Arellano
Certain inborn errors of metabolism result from deficiencies in biotin containing enzymes. These disorders are mimicked by dietary absence or insufficiency of biotin, ATP deficit being a major effect,whose responsible mechanisms have not been thoroughly studied. Here we show that in rats and cultured cells it is the result of reduced TCA cycle flow, partly due to deficient anaplerotic biotin-dependent pyruvate carboxylase. This is accompanied by diminished flow through the electron transport chain, augmented by deficient cytochrome c oxidase (complex IV) activity with decreased cytochromes and reduced oxidative phosphorylation...
November 2015: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/26163321/metabolite-studies-in-hibch-and-echs1-defects-implications-for-screening
#12
Heidi Peters, Sacha Ferdinandusse, Jos P Ruiter, Ronald J A Wanders, Avihu Boneh, James Pitt
3-Hydroxyisobutyryl-CoA hydrolase deficiency (HIBCHD) is a rare inborn error of the valine catabolic pathway associated with Leigh-like disease. We report a female patient who presented at the age of 5months with hypotonia, developmental delay and cerebral atrophy on MRI. Pyruvate dehydrogenase deficiency was initially suspected and decreased activity was shown in fibroblasts. Urine tandem mass spectrometry screening showed large increases in the cysteine conjugate of methacrylate previously described in HIBCHD...
August 2015: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/26046127/urine-and-serum-metabolomic-profiling-reveals-that-bile-acids-and-carnitine-may-be-potential-biomarkers-of-primary-biliary-cirrhosis
#13
Ying-Mei Tang, Jia-Ping Wang, Wei-Min Bao, Jin-Hui Yang, Lin-Kun Ma, Jing Yang, Hui Chen, Ying Xu, Li-Hong Yang, Wen Li, Yan-Ping Zhu, Ji-Bin Cheng
In order to provide non-invasive, reliable and sensitive laboratory parameters for the diagnosis of primary biliary cirrhosis (PBC), metabolic technology of ultraperformance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UPLC/Q-TOF MS) was used to compare small molecule metabolites in blood and urine from patients with PBC and healthy controls. We then screened for bio-markers in the blood and urine of the patients with PBC. Data were processed by Bruker ProfileAnalysis metabonomic software and imported to SIMCA-P software, which utilized principal component analysis (PCA) to create models of patients with PBC and healthy controls...
August 2015: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/25654275/long-term-sex-biased-correction-of-circulating-propionic-acidemia-disease-markers-by-adeno-associated-virus-vectors
#14
Adam J Guenzel, Renata Collard, Jan P Kraus, Dietrich Matern, Michael A Barry
Propionic academia (PA) occurs because of mutations in the PCCA or PCCB genes encoding the two subunits of propionyl-CoA carboxylase, a pivotal enzyme in the breakdown of certain amino acids and odd-chain fatty acids. There is no cure for PA, but dietary protein restriction and liver transplantation can attenuate its symptoms. We show here that a single intravenous injection of adeno-associated virus 2/8 (AAV8) or AAVrh10 expressing PCCA into PA hypomorphic mice decreased systemic propionylcarnitine and methyl citrate for up to 1...
March 2015: Human Gene Therapy
https://www.readbyqxmd.com/read/25534430/branched-chain-amino-acid-metabolism-profiles-in-progressive-human-nonalcoholic-fatty-liver-disease
#15
April D Lake, Petr Novak, Petia Shipkova, Nelly Aranibar, Donald G Robertson, Michael D Reily, Lois D Lehman-McKeeman, Richard R Vaillancourt, Nathan J Cherrington
Nonalcoholic fatty liver disease (NAFLD) is a globally widespread disease of increasing clinical significance. The pathological progression of the disease from simple steatosis to nonalcoholic steatohepatitis (NASH) has been well defined, however, the contribution of altered branched chain amino acid metabolomic profiles to the progression of NAFLD is not known. The three BCAAs: leucine, isoleucine and valine are known to mediate activation of several important hepatic metabolic signaling pathways ranging from insulin signaling to glucose regulation...
March 2015: Amino Acids
https://www.readbyqxmd.com/read/25401479/antioxidant-treatment-prevents-serum-deprivation-and-tnf-%C3%AE-induced-endothelial-dysfunction-through-the-inhibition-of-nadph-oxidase-4-and-the-restoration-of-%C3%AE-oxidation
#16
Maria Giovanna Scioli, Alessandra Bielli, Sara Agostinelli, Chiara Tarquini, Gaetano Arcuri, Amedeo Ferlosio, Gaetana Costanza, Elena Doldo, Augusto Orlandi
AIMS: Oxidative stress plays a pivotal role in the impaired endothelial function occurring in vascular diseases. Antioxidant strategies induce a clinical advantage in patients with endothelial dysfunction and atherosclerosis and protect from oxidative damage, but the underlying molecular mechanisms have been poorly evaluated. The aim of this study was to analyze the effects and mechanisms of action of antioxidant regimens on endothelial function. METHODS AND RESULTS: Antioxidant efficacy of N-acetylcysteine, ascorbic acid and propionyl-L-carnitine was evaluated in serum-deprived and TNF-α-stimulated human umbilical vein endothelial cells in vitro...
2014: Journal of Vascular Research
https://www.readbyqxmd.com/read/25310338/effect-of-craniotomy-on-oxidative-stress-and-its-effect-on-plasma-l-carnitine-levels
#17
Huan-ting Li, Zhen-huan Zhao, Hai-yan Ding, Le-xin Wang, Yu Cao
OBJECTIVE: to investigate the impact of craniotomy on oxidative stress and its effect on levels of plasma L-carnitine (LC). METHODS: plasma levels of reactive oxygen species, superoxide dismutase (SOD), glutathion peroxidase (GSH-Px), catalase (CAT), total antioxidative capacity (T-AOC), and thiobarbituric acid reactive substances (TBARS) were measured in 34 patients (26 males and 8 females, mean age 47.7 ± 6.7 years) before and after craniotomy. Plasma levels of LC, acetyl-L-carnitine (ALC), and propionyl-L-carnitine (PLC) were also measured before and after the craniotomy...
November 2014: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/25205257/proposed-guidelines-for-the-diagnosis-and-management-of-methylmalonic-and-propionic-acidemia
#18
REVIEW
Matthias R Baumgartner, Friederike Hörster, Carlo Dionisi-Vici, Goknur Haliloglu, Daniela Karall, Kimberly A Chapman, Martina Huemer, Michel Hochuli, Murielle Assoun, Diana Ballhausen, Alberto Burlina, Brian Fowler, Sarah C Grünert, Stephanie Grünewald, Tomas Honzik, Begoña Merinero, Celia Pérez-Cerdá, Sabine Scholl-Bürgi, Flemming Skovby, Frits Wijburg, Anita MacDonald, Diego Martinelli, Jörn Oliver Sass, Vassili Valayannopoulos, Anupam Chakrapani
Methylmalonic and propionic acidemia (MMA/PA) are inborn errors of metabolism characterized by accumulation of propionic acid and/or methylmalonic acid due to deficiency of methylmalonyl-CoA mutase (MUT) or propionyl-CoA carboxylase (PCC). MMA has an estimated incidence of ~ 1: 50,000 and PA of ~ 1:100'000 -150,000. Patients present either shortly after birth with acute deterioration, metabolic acidosis and hyperammonemia or later at any age with a more heterogeneous clinical picture, leading to early death or to severe neurological handicap in many survivors...
2014: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/25204964/maternal-vitamin-b12-deficiency-detected-in-expanded-newborn-screening
#19
Emanuela Scolamiero, Guglielmo Rosario Domenico Villani, Laura Ingenito, Rita Pecce, Lucia Albano, Marianna Caterino, Maria Grazia di Girolamo, Cristina Di Stefano, Ignazio Franzese, Giovanna Gallo, Margherita Ruoppolo
OBJECTIVES: Besides the inherited form, vitamin B(12) deficiency may be due to diet restrictions or abnormal absorption. The spread of newborn screening programs worldwide has pointed out that non-inherited conditions are mainly secondary to a maternal deficiency. The aim of our work was to study seven cases of acquired vitamin B12 deficiency detected during our newborn screening project. Moreover, we aimed to evaluate vitamin B(12) and related biochemical parameters status on delivering female to verify the consequences on newborns of eventually altered parameters...
December 2014: Clinical Biochemistry
https://www.readbyqxmd.com/read/24783852/-identification-of-spore-germination-and-virulence-related-biomarkers-from-beauveria-bassiana-using-an-lc-ms-based-metabolomic-technique
#20
Feifei Luo, Shulin Li, Longyun Chen, Wancun Zhang, Bin Wang, Bo Huang, Fenglin Hu
OBJECTIVE: To identify biomarkers associated with germination and virulence of Beauveria bassiana. METHODS: Spore germination rate and virulence of seven B. bassiana isolates against Euproctis pseudoconspersa were determined, and an LC-MS-based metabolomic analysis was applied to identify the biomarkers from mycelia and conidial extracts associated with spore germination and virulence. RESULTS: The metabolites of carnitine, hercynine, acetylcarnitine, alpha, alpha-trehalose; Octa-Me, arg-arg-gln, phosphatidylethanolamine (PE(18:2/0:0)), phosphotidylcholine (PC(18:3/0:0)) and PC(18:2/0:0)) were higher in the mycelia of highly virulent isolates than those less virulent strains...
January 4, 2014: Wei Sheng Wu Xue Bao, Acta Microbiologica Sinica
keyword
keyword
118134
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"