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Omar Al Kadhi, Maria H Traka, Antonietta Melchini, Perla Troncoso-Rey, Wiktor Jurkowski, Marianne Defernez, Purnima Pachori, Robert D Mills, Richard Y Ball, Richard F Mithen
The human prostate gland comprises three distinct anatomical glandular zones, namely the peripheral, central and transitional zones. Although prostate cancer can arise throughout the prostate, it is more frequent in the peripheral zone. In contrast, hyperplasia occurs most frequently in the transitional zone. In this paper, we test the hypothesis that peripheral and transitional zones have distinct metabolic adaptations that may underlie their different inherent predispositions to cancer and hyperplasia. In order to do this, we undertook RNA sequencing and high-throughput metabolic analyses of non-cancerous tissue from the peripheral and transitional zones of patients undergoing prostatectomy...
October 17, 2017: Oncotarget
Yury S Bykov, Miroslava Schaffer, Svetlana O Dodonova, Sahradha Albert, Jürgen M Plitzko, Wolfgang Baumeister, Benjamin D Engel, John Ag Briggs
COPI-coated vesicles mediate trafficking within the Golgi apparatus and from the Golgi to the endoplasmic reticulum. The structures of membrane protein coats, including COPI, have been extensively studied with in vitro reconstitution systems using purified components. In a previous paper (Dodonova et al., 2017), we determined a complete structural model of the in vitro reconstituted COPI coat. Here, we applied cryo-focused ion beam milling, cryo-electron tomography and subtomogram averaging to determine the native structure of the COPI coat within vitrified Chlamydomonas reinhardtii cells...
November 17, 2017: ELife
Katie Mills, Emma Harte, Adam Martin, Calum MacLure, Simon J Griffin, Jonathan Mant, Catherine Meads, Catherine L Saunders, Fiona M Walter, Juliet A Usher-Smith
OBJECTIVE: To synthesise data concerning the views of commissioners, managers and healthcare professionals towards the National Health Service (NHS) Health Check programme in general and the challenges faced when implementing it in practice. DESIGN: A systematic review of surveys and interview studies with a descriptive analysis of quantitative data and thematic synthesis of qualitative data. DATA SOURCES: An electronic literature search of MEDLINE, Embase, Health Management Information Consortium, Cumulative Index of Nursing and Allied Health Literature, Global Health, PsycInfo, Web of Science, OpenGrey, the Cochrane Library, NHS Evidence, Google Scholar, Google, ClinicalTrials...
November 15, 2017: BMJ Open
Ninad Oke, Swati Singh, Anurag Garg
The bleaching effluent discharged from a pulp and paper mill contains chlorinated organic compounds which are toxic to living matter. Physicochemical treatments such as coagulation and different advanced oxidation processes (AOPs) were employed for combined bleaching effluent generated from the first two stages (i.e. chlorination and alkali extraction) (pH = 3.5, chemical oxygen demand (COD) = 1,920 mg/L, and total organic carbon (TOC) = 663 mg/L). At optimum conditions (pH = 7.5, polyaluminium chloride (PAC) dose = 3...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Andrew Mulderig, Gregory Beaucage, Karsten Vogtt, Hanqiu Jiang, Yan Jin, Lisa Clapp, Donald Henderson
Particle dispersions, such as pigment-based inks, comprise weakly bound, milled nanoparticles. The properties of these pigments depend on both their chemical composition, as well as a rather complex structural hierarchy, which emerges from these dispersions. The emergence of structure under semi-dilute conditions is related to the structure of the dilute particles, the particle spacing (mesh size), processing history, and the interaction potential. Kinetic simulations could predict such emergence using these input parameters...
November 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Paul C Snelling
This is lightly edited and referenced version of a presentation given at the 20th International Philosophy of Nursing conference in Quebec on 23rd August 2016. Philosophical texts are not given the same prominence in nurse education as their more valued younger sibling, primary research evidence, but they can influence practice through guidelines, codes and espoused values. John Stuart Mill's harm principle, found in On Liberty, is not a universal law, and only a thoroughgoing libertarian would defend it as such, though it, or its remnants, can be seen can be seen in policy documents...
November 15, 2017: Nursing Philosophy: An International Journal for Healthcare Professionals
Ning Yan, Xiao-Fang Wan, Xin-Sheng Chai, Run-Quan Chen, Chun-Xia Chen
This paper reports on an ionic-liquid assisted headspace gas chromatographic (HS-GC) for the determination of the content of alkyl ketene dimer (AKD) in its latex samples, in which the GC system was equipped with a thermal conductivity detector (TCD). The method was based on the AKD hydrolysis conducted in 1-butyl-3-methylimidazolium chloride (ionic-liquid) added medium at 100°C for 10min in a closed headspace sample vial, and the measured CO2 (the resulting product of the hydrolysis) by HS-GC. The results showed that the present method has a good measurement precision (RSD <2...
November 7, 2017: Journal of Chromatography. A
Ali Akhtar, Ajit K Sarmah
In this study, biochar, a carbonaceous solid material produced from three different waste sources (poultry litter, rice husk and pulp and paper mill sludge) was utilized to replace cement content up to 1% of total volume and the effect of individual biochar mixed with cement on the mechanical properties of concrete was investigated through different characterization techniques. A total of 168 samples were prepared for mechanical testing of biochar added concrete composites. The results showed that pulp and paper mill sludge biochar at 0...
November 8, 2017: Science of the Total Environment
Miguel Monteiro, Rui Figueira, Martim Melo, Michael Stuart Lyne Mills, Pedro Beja, Cristiane Bastos-Silveira, Manuela Ramos, Diana Rodrigues, Isabel Queirós Neves, Susana Consciência, Luís Reino
The Instituto de Investigação Científica Tropical of the University of Lisbon, which resulted from the recent merger (in 2015) of the former state laboratory Instituto de Investigação Científica Tropical in the University of Lisbon, holds an important collection of bird skins from the Portuguese-speaking African Countries (Angola, Mozambique, São Tomé and Príncipe, Guinea Bissau and Cape Verde), gathered as a result of several scientific expeditions made during the colonial period. In this paper, the subset from Mozambique is described, which was taxonomically revised and georeferenced...
2017: ZooKeys
Guang Yang, Hao Ding, Jiejie Feng, Qiang Hao, Sijia Sun, Weihua Ao, Daimei Chen
In this paper, a highly efficient core-shell structure of TiO2(B)/anatase photocatalyst with CoP cocatalyst has been synthesized via hydrothermal processes and a mechanical milling method. The designed core-shell TiO2(B)/anatase photocatalysts exhibit excellent performance by compared with pure TiO2(B) and anatase phase. With the participation of CoP particles, there is drastically enhanced  photocatalytic activity of TiO2(B)/anatase, and the H2-production rate can be up to 7400 μmol·g(-1), which is about 3...
November 6, 2017: Scientific Reports
Chen Li, Gerlinde Habler, Lisa C Baldwin, Rainer Abart
Focused ion beam (FIB) sample preparation technique in plan-view geometry allows direct correlations of the atomic structure study via transmission electron microscopy with micrometer-scale property measurements. However, one main technical difficulty is that a large amount of material must be removed underneath the specimen. Furthermore, directly monitoring the milling process is difficult unless very large material volumes surrounding the TEM specimen site are removed. In this paper, a new cutting geometry is introduced for FIB lift-out sample preparation with plan-view geometry...
September 28, 2017: Ultramicroscopy
Vanessa Heaslip, Janet Scammell, Anne Mills, Ashley Spriggs, Andrea Addis, Mandy Bond, Carolyn Latchford, Angela Warren, Juliet Borwell, Stephen Tee
AIM: Within the United Kingdom (UK) there is an increasing focus on Values Based Recruitment (VBR) of staff working in the National Health Service (NHS) in response to public inquiries criticising the lack of person-centred care. All NHS employees are recruited on the basis of a prescribed set of values. This is extended to the recruitment of student healthcare professionals, yet there is little research of how to implement this. Involving Service Users in healthcare educational practice is gaining momentum internationally, yet involvement of service users in VBR of 'would be' healthcare professionals remains at an embryonic phase...
October 6, 2017: Nurse Education Today
Jiheng Ding, Hongran Zhao, Qiaolei Wang, Huimin Dou, Hao Chen, Haibin Yu
Graphene nanosheets (GNSs) possess outstanding conductivity, good thermal and chemical stabilities and desirable mechanical strengths. However, the unfunctionalized GNSs are hydrophobic and insoluble in water, which limits their application in many technological areas. Herein, we report a design strategy to exfoliate few-layered aqueous dispersible graphene by a simple ball-milling technique. The modifier of sodium lignosulfonate (LS) enables to synthesize LS-decorated GNSs from natural graphite based on the strong π-π interaction, greatly improving GNSs dispersion in water...
November 9, 2017: Nanoscale
Senem Yazici Guvenc, Hanife Sari Erkan, Gamze Varank, Mehmet Sinan Bilgili, Guleda Onkal Engin
This study deals with chemical oxygen demand (COD), phenol and Ca(+2) removal from paper mill industry wastewater by electrocoagulation (EC) and electro-Fenton (EF) processes. A response surface methodology (RSM) approach was employed to evaluate the effects and interactions of the process variables and to optimize the performance of both processes. Significant quadratic polynomial models were obtained (R(2) = 0.959, R(2) = 0.993 and R(2) = 0.969 for COD, phenol and Ca(+2) removal, respectively, for EC and R(2) = 0...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Yuhang Xu, Verity M McClelland, Zoran Cvetkovic, Kerry R Mills
Functional coupling between the motor cortex and muscle activity is usually detected and characterized using the spectral method of cortico-muscular coherence (CMC) between surface electromyogram (sEMG) and electroencephalogram (EEG) recorded synchronously under motor control task. However, CMC is often weak and not easily detectable in all individuals. One of the reasons for the low levels of CMC is the presence of noise and components unrelated to the considered tasks in recorded sEMG and EEG signals. In this paper we propose a method for enhancing relative levels of sEMG components coherent with synchronous EEG signals via a variant of Wavelet Independent Component Analysis combined with a novel component selection algorithm...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Steven Kinio, James K Mills
This paper presents the design and experimental performance of a microelectrode-based device to selectively lyse cells in a flow in a microfluidic channel. Localized cell lysis is achieved by utilizing "irreversible electroporation", in which cells are exposed to high magnitude electric pulses. Localized cell lysis in a flow has research applications and may allow for removal of harmful cells such as circulating tumor cells from blood. Due to the dependence of this technique on the magnitude of the applied electric field, lethal electric field regions can be localized in the channel by calibration of the applied voltage...
October 17, 2017: IEEE Transactions on Nanobioscience
C R German, K A Casciotti, J-C Dutay, L E Heimbürger, W J Jenkins, C I Measures, R A Mills, H Obata, R Schlitzer, A Tagliabue, D R Turner, H Whitby
Hydrothermal activity occurs in all ocean basins, releasing high concentrations of key trace elements and isotopes (TEIs) into the oceans. Importantly, the calculated rate of entrainment of the entire ocean volume through turbulently mixing buoyant hydrothermal plumes is so vigorous as to be comparable to that of deep-ocean thermohaline circulation. Consequently, biogeochemical processes active within deep-ocean hydrothermal plumes have long been known to have the potential to impact global-scale biogeochemical cycles...
November 28, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Cecily A Flemming, Vince Pileggi, Shu Chen, Susan S Lee
Regulatory policies to manage land application of organic materials are risk based, with focus on the quality of these residuals. The Ontario Ministry of the Environment and Climate Change (MOECC) determined that limited information was available on pulp and paper biosolids (PPB) with respect to human enteric pathogens. To address this data gap, MOECC conducted an extensive survey (2005-2006) across Ontario to characterize the microbiological quality of PPB. Quantitative testing was performed for fecal indicators (, enterococci, ) and enteric pathogens (, , , and ) using matrix-validated methods...
September 2017: Journal of Environmental Quality
Patrick Faubert, Simon Durocher, Normand Bertrand, Rock Ouimet, Philippe Rochette, Pascal Tremblay, Jean-François Boucher, Claude Villeneuve
Large areas of mine tailings are reclaimed by applying organic amendments such as paper mill sludge (PMS). Although mining industries can use PMS freshly generated by paper mills, operational constraints on paper industries make temporary landfilling of this material an unavoidable alternative for the paper industries, creating the most prominent PMS source for mining industries. This study aimed to quantify soil greenhouse gas (GHG) emissions (NO, CO, and CH) after application of landfilled PMS (LPMS; i.e...
September 2017: Journal of Environmental Quality
Hanife Sari Erkan, Guleda Onkal Engin
The paper mill industry produces high amounts of wastewater and, for this reason, stringent discharge limits are applied for sustainable reclamation and reuse of paper mill industry wastewater in many countries. Submerged membrane bioreactor (sMBR) systems can create new opportunities to eliminate dissolved substances present in paper mill wastewater including. In this study, a sMBR was operated for the treatment of paper mill industry wastewater at 35 h of hydraulic retention time (HRT) and 40 d of sludge retention time (SRT)...
October 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
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