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https://www.readbyqxmd.com/read/29776849/immune-factors-in-deep-vein-thrombosis-initiation
#1
REVIEW
Ivan Budnik, Alexander Brill
Deep vein thrombosis (DVT) is a major origin of morbidity and mortality. While DVT has long been considered as blood coagulation disorder, several recent lines of evidence demonstrate that immune cells and inflammatory processes are involved in DVT initiation. Here, we discuss these mechanisms, in particular, the role of immune cells in endothelial activation, and the immune cascades leading to expression of adhesion receptors on endothelial cells. We analyze the specific recruitment and functional roles of different immune cells, such as mast cells and leukocytes, in DVT...
May 15, 2018: Trends in Immunology
https://www.readbyqxmd.com/read/29775893/puerarin-prevents-vascular-endothelial-injury-through-suppression-of-nf-%C3%AE%C2%BAb-activation-in-lps-challenged-human-umbilical-vein-endothelial-cells
#2
Hua-Fei Deng, Sha Wang, Lian Li, Qin Zhou, Wan-Bei Guo, Xiao-Li Wang, Mei-Dong Liu, Ke Liu, Xian-Zhong Xiao
OBJECTIVE: In the present study, we aimed to explore the effects of puerarin on vascular endothelial cell injury induced by lipopolysaccharide (LPS) and its underlying mechanisms. METHODS: The cell viability and morphological changes were assessed using the cell counting kit-8 (CCK-8) assay and 4´,6-diamidino-2-phenylindole (DAPI) staining, respectively. The levels of tumor necrosis factor-alpha (TNF-α), interleukin-1β (IL-1β), monocyte/macrophage chemotactic protein-1 (MCP-1), IL-8, intercellular cell adhesion molecule-1 (ICAM-1), thrombomodulin (TM) and plasminogen activator inhibitor-1 (PAI-1) in cell culture supernatant were determined by the enzyme-linked immunosorbent assay (ELISA)...
May 15, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29746945/activation-of-coagulation-and-endothelium-with-concurrent-impairment-of-anticoagulant-mechanisms-in-patients-with-typhoid-fever
#3
Hanna K de Jong, Chris M Parry, Thomas W van der Vaart, Liesbeth M Kager, Stannie J van den Ende, Rapeephan R Maude, Lalith Wijedoru, Aniruddha Ghose, Mohammed U Hasan, Mohammed A Hossain, Arjan M Dondorp, Steve Baker, M Abul Faiz, Joost C M Meijers, W Joost Wiersinga
OBJECTIVES: Typhoid fever caused by Salmonella Typhi remains a major burden worldwide. Gastrointestinal bleeding can be seen in up to 10 percent of patients and may be fatal. The coagulopathy, which may be the driver of this severe complication in patients with typhoid fever, however is ill defined. The aim of this study was to evaluate the activation of coagulation, anticoagulation, and fibrinolysis in patients with acute typhoid fever. METHODS: . Parameters of coagulation and fibrinolysis were measured in 28 hospitalized patients with culture-confirmed or PCR-confirmed typhoid fever and compared to 38 age- and sex-matched healthy volunteers...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29742907/new-interfaces-of-thyroid-hormone-actions-with-blood-coagulation-and-thrombosis
#4
Paul J Davis, Shaker A Mousa, Geraldine P Schechter
Substantial clinical evidence indicates hyperthyroidism enhances coagulation and increases the risk of thrombosis. In vitro and clinical evidence implicate multiple mechanisms for this risk. Genomic actions of thyroid hormone as 3,5,3'-triiodo-L-thyronine (T3 ) via a nuclear thyroid hormone receptor have been implicated, but recent evidence shows that nongenomic mechanisms initiated at the receptor for L-thyroxine (T4 ) on platelet integrin αvβ3 are prothrombotic. The T4 -initiated mechanisms involve platelet activation and, in addition, cellular production of cytokines and chemokines such as CX3CL1 with procoagulatory activities...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29735342/dabigatran-reduces-endothelial-permeability-through-inhibition-of-thrombin-induced-cytoskeleton-reorganization
#5
Hyun-Jung Choi, Na-Eun Kim, Jayoung Kim, Sunho An, Seung-Hee Yang, Jimin Ha, Sunghee Cho, Il Kwon, Young Dae Kim, Hyo Suk Nam, Ji Hoe Heo
Dabigatran etexilate (DE), a new oral anti-coagulant, is a direct thrombin inhibitor. Clinical trials showed the favorable benefit-to-risk profile of DE compared to warfarin for the prevention of ischemic stroke in patients with atrial fibrillation. Remarkably, patients treated with dabigatran showed reduced rates of intracerebral hemorrhage compared to warfarin. As the breakdown of endothelial barrier integrity is associated with hemorrhagic events and as thrombin increases endothelial permeability, we hypothesized that dabigatran preserves the endothelial barrier by inhibiting thrombin-induced permeability...
April 25, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29716435/micromolar-zinc-in-annexin-a5-anticoagulation-as-a-potential-remedy-for-rprgl3-associated-recurrent-pregnancy-loss
#6
Hayrünnisa Danisik, Nadia Bogdanova, Arseni Markoff
Deficient expression of the placental anticoagulant annexin A5 (ANXA5) has been associated with thrombophilia-related pregnancy complications and ultimately with recurrent pregnancy loss (RPL). Carrier status of M2/ANXA5 ( RPRGL3), common ANXA5 promoter variant, has been identified as genetic cause of reduced ANXA5 levels and proposed as biomarker for successful anticoagulant treatment of RPL women. A murine model of AnxA5 loss of function displayed characteristic placental pathology and fetal loss that was alleviated through anticoagulant intervention...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29703471/the-intersection-of-protein-disulfide-isomerase-and-cancer-associated-thrombosis
#7
Jack D Stopa, Jeffrey I Zwicker
The mechanisms underlying the hypercoagulability of cancer are complex and include the upregulation coagulation factors or procoagulant proteins, shedding of microparticles, and direct activation of vascular cells. Protein disulfide isomerase (PDI) is a thiol isomerase secreted from activated platelets and endothelial cells and plays a critical role in both platelet aggregation and fibrin generation. A number of potential intravascular targets of PDI have been identified including cell surface receptors (e...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29703240/temporal-phenotyping-of-circulating-microparticles-after-trauma-a-prospective-cohort-study
#8
Matthias Fröhlich, Nadine Schäfer, Michael Caspers, Julia K Böhm, Ewa K Stürmer, Bertil Bouillon, Marc Maegele
BACKGROUND: After severe polytrauma the dynamic process of coagulation may deteriorate towards a trauma-induced coagulopathy (TIC) promoting a dramatic increase in morbidity and mortality. Recent evidence suggests that microparticles (MPs) play a pivotal role at the interface between cellular and plasmatic coagulation systems. However, the impact of MPs on functional coagulation has not been clarified yet in the setting of traumatic injuries. We assessed the temporal patterns of circulating MP concentrations including their cellular origin in the context of clinical presentation and global coagulation assays...
April 27, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29687628/proteomic-profiling-exosomes-from-vascular-smooth-muscle-cell
#9
Hong Qiu, Songshan Shi, Shunchun Wang, Hong Peng, Shi-Jian Ding, Lianchun Wang
PURPOSE: Vascular smooth muscle cells (VSMC) and endothelial cells (EC) communicate mutually to coordinate vascular development and homeostasis. Exosomes are emerging as one type of the mediators involved in this communication. Characterizing proteins in the exosomes is the critical first step in understanding how the VSMC-EC crosstalk is mediated by exosomes. EXPERIMENTAL DESIGN: We profiled the proteins in the human VSMC-derived exosomes using nanoLC-MS/MS based proteomics...
April 24, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29678818/angiolymphoid-hyperplasia-of-external-ear-treated-with-intralesional-radiofrequency-ablation
#10
Deepika Yadav, Sanjay Singh, Neetu Bhari, Somesh Gupta
A 21-year-old woman presented with multiple erythematous to skin-coloured dome-shaped firm papules and plaques over the right ear concha and external auditory canal for 1 year. It was associated with occasional itching and bleeding. Her main concern was cosmetic disfigurement. Biopsy showed presence of multiple proliferating blood vessels lined by plump epithelioid endothelial cells surrounded by dense infiltrate of lymphocytes, histiocytes and eosinophils. Other routine investigations were within normal limits...
April 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29674197/villous-explants-from-preeclamptic-placentas-induce-sflt1-in-pbmcs-an-ex-vivo-co-culture-study
#11
Stephen Kyle Gonzales, Martina Badell, Hanh Cottrell, Bassam Rimawi, Venkataraman Deepak, Neil Sidell, Augustine Rajakumar
OBJECTIVES: Soluble Flt1 (sFlt1) is an anti-angiogenic protein linked to the pathology of preeclampsia (PE). While the placenta serves as the major organ producing sFlt1 during normal pregnancy, peripheral blood mononuclear cells (PBMCs), endothelial cells, and stromal cells also produce sFlt1. The key question is 'what drives the overexpression of sFlt1 observed during PE?' In the present work we show evidence for sFlt1 over-expression in PBMCs due to interaction with placental villi from PE patients...
February 25, 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29672166/the-effect-of-leech-extracts-on-endothelial-cell-coagulation-related-factors-and-endothelial-dysfuction-related-molecules
#12
Lixu Xu, Xue Li, E Zhang, Hao Liang, Weiting Li, Shangyi Wang, Shuliang Song, Aiguo Ji
OBJECTIVE: This study was focused on screening leech extracts to identify those with little or no anti-coagulation effect or with significant anti-endothelial dysfunction activity. METHODS: Different leech extracts were prepared by enzymolysis and microbial transformation and their cytotoxicity were measured by MTT assay. The effect of different leech extracts on mRNA expression of coagulation-related factors (PAI, vWF, tPA, PS, TFPI, TM) was quantified by RT-PCR...
April 19, 2018: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/29667205/application-of-heparin-collagen-redv-selective-active-interface-on-eptfe-films-to-enhance-endothelialization-and-anticoagulation
#13
Yaping Shan, Bing Jia, Ming Ye, Hua Shen, Weicheng Chen, Huifeng Zhang
Expanded polytetrafluoroethylene (ePTFE) prosthetic valves have been widely used in clinical applications in Asian countries. However, these valves still have limits with regard to thrombosis, neointimal hyperplasia, restenosis, and valvar vegetation. The achievement of in situ endothelialization on implant materials is a promising way to overcome those limits. Here, heparin/collagen multilayers were fabricated on ePTFE films via a layer-by-layer (LBL) self-assembly technique, and then, the endothelial cell (EC) adhesive peptide sequence Arg-Glu-Asp-Val (REDV) was immobilized on the multilayers...
April 18, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29662195/ngr-asn-gly-arg-targeted-delivery-of-coagulase-to-tumor-vasculature-arrests-cancer-cell-growth
#14
Khaled Seidi, Rana Jahanban-Esfahlan, Hassan Monhemi, Peyman Zare, Babak Minofar, Amir Daei Farshchi Adli, Davoud Farajzadeh, Ramezan Behzadi, Mehran Mesgari Abbasi, Heidi A Neubauer, Richard Moriggl, Nosratollah Zarghami, Tahereh Javaheri
Induction of selective thrombosis and infarction in tumor-feeding vessels represents an attractive strategy to combat cancer. Here we took advantage of the unique coagulation properties of staphylocoagulase and genetically engineered it to generate a new fusion protein with novel anti-cancer properties. This novel bi-functional protein consists of truncated coagulase (tCoa) and an NGR (GNGRAHA) motif that recognizes CD13 and αv β3 integrin receptors, targeting it to tumor endothelial cells. Herein, we report that tCoa coupled by its C-terminus to an NGR sequence retained its normal binding activity with prothrombin and av β3 integrins, as confirmed in silico and in vitro...
April 17, 2018: Oncogene
https://www.readbyqxmd.com/read/29658397/inflammation-coagulation-response-and-thrombotic-effects-induced-by-silica-nanoparticles-in-zebrafish-embryos
#15
Junchao Duan, Shuang Liang, Yang Yu, Yang Li, Lijing Wang, Zehao Wu, Yueyue Chen, Mark R Miller, Zhiwei Sun
Nowadays, nanotechnology environmental health and safety (nanoEHS) is gaining attention. We previously found that silica nanoparticles (SiNPs) could induce vascular endothelial damage. However, the subsequent toxicologic response to SiNPs-induced endothelial damage was still largely unknown. In this study, we explored the inflammation-coagulation response and thrombotic effects of SiNPs in endothelial cells and zebrafish embryos. For in vitro study, swollen mitochondria and autophagosome were observed in ultrastructural analysis...
April 14, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29653462/docosahexaenoic-acid-reversed-atherosclerotic-changes-in-human-endothelial-cells-induced-by-palmitic-acid-in-vitro
#16
Saeede Karbasforush, Alireza Nourazarian, Masoud Darabi, Reza Rahbarghazi, Fatemeh Khaki-Khatibi, Çıgır Biray Avci, Leila Salimi, Bakiye Goker Bagca, Tanaz Novin Bahador, Aysa Rezabakhsh, Majid Khaksar
Abnormal activity of atherosclerotic endothelial cells paving luminal surface of blood vessels has been described in many diseases. It has been reported that natural polyunsaturated fatty acids such as docosahexaenoic acid exert therapeutic effects in atherosclerotic condition. Human umbilical vein endothelial cells were treated with 1mM palmitic acid for 48 hours and exposed to 40μM docosahexaenoic acid for the next 24 hours. Real-time polymerase chain reaction analysis was used to measure the expression of PTX3, iNOS, and eNOS...
April 13, 2018: Cell Biochemistry and Function
https://www.readbyqxmd.com/read/29650693/high-mobility-group-box-1-from-hypoxic-trophoblasts-promotes-endothelial-microparticle-production-and-thrombophilia-in-preeclampsia
#17
Yae Hu, Ruhong Yan, Ce Zhang, Zhichao Zhou, Meng Liu, Can Wang, Hong Zhang, Liang Dong, Tiantian Zhou, Yi Wu, Ningzheng Dong, Qingyu Wu
OBJECTIVE: Thrombophilia is a major complication in preeclampsia, a disease associated with placental hypoxia and trophoblast inflammation. Preeclampsia women are known to have increased circulating microparticles that are procoagulant, but the underlying mechanisms remain unclear. In this study, we sought to understand the mechanism connecting placental hypoxia, circulating microparticles, and thrombophilia. APPROACH AND RESULTS: We analyzed protein markers on plasma microparticles from preeclampsia women and found that the increased circulating microparticles were mostly from endothelial cells...
April 12, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29621007/disseminated-intravascular-coagulation-is-it-fact-or-fancy
#18
Jae C Chang
: 'Disseminated intravascular coagulation (DIC)' occurs commonly in critical illnesses such as sepsis, trauma, cancer, and complications of surgery and pregnancy. Mortality is very high. The pathogenesis has been ascribed to tissue factor-initiated coagulation disorder, resulting in disseminated microblood clots that are made of platelets, plasma factors, fibrins, and blood cells. True DIC depletes coagulation factors and consumes platelets, and activates fibrinolysis. 'DIC' is assumed to orchestrate thrombocytopenia, microangiopathic hemolytic anemia and hypoxic multiorgan dysfunction syndrome, and causes hemorrhagic disorder due to depleted coagulation factors...
April 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29620266/phosphatidylserine-exposing-cells-contribute-to-the-hypercoagulable-state-in-patients-with-multiple-myeloma
#19
Li Guo, Dongxia Tong, Muxin Yu, Yan Zhang, Tao Li, Chunxu Wang, Peng Zhou, Jiaqi Jin, Baorong Li, Yingmiao Liu, Ruipeng Liu, Valerie A Novakovic, Zengxiang Dong, Ye Tian, Junjie Kou, Yayan Bi, Jin Zhou, Jialan Shi
Multiple myeloma (MM) is characterized by an increased incidence of thromboembolic events, particularly when treated with immunomodulatory drugs (IMiDs) in combination with dexamethasone. The optimal prophylactic strategy to prevent the hypercoagulable state of patients with MM is still debated. The aim of the current study was to investigate the definitive role of phosphatidylserine (PS) in supporting procoagulant activity (PCA) in patients with MM. Patients with MM (n=20) and healthy subjects (n=15) were recruited for the present study...
April 3, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29619369/cell-receptor-and-cofactor-interactions-of-the-contact-activation-system-and-factor-xi
#20
REVIEW
Monika Pathak, Bubacarr Gibril Kaira, Alexandre Slater, Jonas Emsley
The contact activation system (CAS) or contact pathway is central to the crosstalk between coagulation and inflammation and contributes to diverse disorders affecting the cardiovascular system. CAS initiation contributes to thrombosis but is not required for hemostasis and can trigger plasma coagulation via the intrinsic pathway [through factor XI (FXI)] and inflammation via bradykinin release. Activation of factor XII (FXII) is the principal starting point for the cascade of proteolytic cleavages involving FXI, prekallikrein (PK), and cofactor high molecular weight kininogen (HK) but the precise location and cell receptor interactions controlling these reactions remains unclear...
2018: Frontiers in Medicine
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