Xinyi Wang, Zhengchao Yuan, Muhammad Shafiq, Guangfang Cai, Zheng Lei, Yifan Lu, Xiangheng Guan, Rashida Hashim, Mohamed El-Newehy, Meera Moydeen Abdulhameed, Xiao Lu, Yuan Xu, Xiumei Mo
Poor hemostatic ability and less vascularization at the injury site could hinder wound healing as well as adversely affect the quality of life (QOL). An ideal wound dressing should exhibit certain characteristics: (a) good hemostatic ability, (b) rapid wound healing, and (c) skin appendage formation. This necessitates the advent of innovative dressings to facilitate skin regeneration. Therapeutic ions, such as silicon ions (Si4+ ) and calcium ions (Ca2+ ), have been shown to assist in wound repair. The Si4+ released from silica (SiO2 ) can upregulate the expression of proteins, including the vascular endothelial growth factor (VEGF) and alpha smooth muscle actin (α-SMA), which is conducive to vascularization; Ca2+ released from tricalcium phosphate (TCP) can promote the coagulation alongside upregulating the expression of cell migration and cell differentiation related proteins, thereby facilitating the wound repair...
May 8, 2024: ACS Applied Materials & Interfaces