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"blood coagulation mechanism" and "endothelial cell"

Hadil A Al Otair, Abdel Galil M Abdel Gader, Syed M Khurshid, Abdulaziz H Alzeer, Abdul Kareem Al Momen, Mashael Al Shaikh, Farja Al Gahtani, Zohair A Al Aseri, Hossam A H Abdelrazik
OBJECTIVE: Sepsis syndrome is usually accompanied by activation of blood coagulation mechanisms. Earlier studies found deficiencies of the 3 main natural anticoagulants, antithrombin, protein C, and protein S. However, none of these inhibitors block tissue factor, the prime trigger of coagulation during sepsis that is controlled specifically by the tissue factor pathway inhibitor (TFPI). The aim of this study was to characterize the fluctuations in the levels of natural anticoagulants, particularly TFPI, in the course of sepsis and to find out their association with the anticoagulant action of the low-molecular-weight heparin enoxaparin...
June 5, 2016: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
M Z Wojtukiewicz, L R Zacharski, M Ruciñska, L Zimnoch, J Jaromin, M Rózañska-Kudelska, W Kisiel, B J Kudryk
The blood coagulation mechanism may support tumor progression by several mechanisms including promotion of cell proliferation and angiogenesis. Immunohistochemical procedures were applied to AMeX-fixed sections of twelve cases of squamous cell carcinoma of the larynx obtained at surgical resection to determine the presence and distribution of tissue factor (TF), tissue factor pathway inhibitor (TFPI), other coagulation factors, fibrinogen, and fibrin in situ. TF antigen was present in normal squamous epithelial cells and tumor cells, predominantly in immature tumor cells in the vicinity of the host-tumor interface...
December 1999: Thrombosis and Haemostasis
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