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Apnea of prematurity

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https://www.readbyqxmd.com/read/29765059/postnatal-microstructural-developmental-trajectory-of-corpus-callosum-subregions-and-relationship-to-clinical-factors-in-very-preterm-infants
#1
Radhika Teli, Margaret Hay, Alexa Hershey, Manoj Kumar, Han Yin, Nehal A Parikh
Our objectives were to define the microstructural developmental trajectory of six corpus callosum subregions and identify perinatal clinical factors that influence early development of these subregions in very preterm infants. We performed a longitudinal cohort study of very preterm infants (32 weeks gestational age or younger) (N = 36) who underwent structural MRI and diffusion tensor imaging serially at four time points - before 32, 32, 38, and 52 weeks postmenstrual age. We divided the corpus callosum into six subregions, performed probabilistic tractography, and used linear mixed effects models to evaluate the influence of antecedent clinical factors on its microstructural growth trajectory...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740701/characteristics-and-circadian-distribution-of-cardiac-arrhythmias-in-patients-with-heart-failure-and-sleep-disordered-breathing
#2
Hazem Omran, Thomas Bitter, Dieter Horstkotte, Olaf Oldenburg, Henrik Fox
BACKGROUND: Cardiac arrhythmias and sleep-disordered breathing (SDB) are common comorbidities in heart failure with reduced ejection fraction (HFrEF). However, understanding of the association between arrhythmias and SDB is poor. This study assessed the occurrence and circadian distribution of ventricular arrhythmias in HFrEF patients with and without SDB. METHODS: This retrospective analysis included HFrEF patients admitted for unattended overnight cardiorespiratory polygraphy and 24-h Holter-ECG recording...
May 8, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29694990/respiratory-instability-and-hypoxemia-episodes-in-preterm-infants
#3
Eduardo Bancalari, Nelson Claure
Oxygenation instability is a very common problem in the premature infant that manifests as intermittent hypoxemia episodes (HEs). These are particularly frequent in premature infants who are on mechanical ventilation beyond the first weeks after birth. However, they can also occur in spontaneously breathing infants. Some of these episodes are due to central apnea, but in ventilated infants, they are frequently due to contractions of the abdominal musculature that can splint the respiratory pump, resulting in periods of decreased lung volume and hypoventilation...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29673564/factors-affecting-the-efficacy-and-safety-of-aminophylline-in-treatment-of-apnea-of-prematurity-in-neonatal-intensive-care-unit
#4
Chaohui Ye, Caiyun Miao, Li Yu, Zhuoya Dong, Jie Zhang, Yingying Mao, Xiaodong Lu, Qin Lyu
BACKGROUND: The factors affecting the safety and efficacy of aminophylline use in the treatment of apnea of prematurity (AOP) in the neonatal intensive care unit (NICU) are not clear. In this study, we aimed to evaluate the potential factors affecting the efficacy and safety of aminophylline in AOP treatment at standard doses and to determine appropriate patients for this therapy. METHODS: Over a 3-year period (January 2012 to December 2014), the medical records of 206 preterm infants with apnea who were admitted to the NICU of our hospital to receive aminophylline infusions were retrospectively reviewed...
March 30, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29649028/does-the-incidence-of-postoperative-complications-after-inguinal-hernia-repair-justify-hospital-admission-in-prematurely-and-term-born-infants
#5
Marina Massoud, A Y Rosalie Kühlmann, Monique van Dijk, Lonneke M Staals, Rene M H Wijnen, Joost van Rosmalen, Cornelius E J Sloots, Claudia M G Keyzer-Dekker
BACKGROUND: Postoperatively, young infants are admitted overnight in view of the risk for respiratory complications such as desaturation and apnea. This risk seems much lower than previously reported. Until what age this risk persists, and which infants might actually qualify for day-care treatment, is unknown. METHODS: We retrospectively reviewed medical charts from preterm infants <45 weeks postconceptional age (PCA), 45-60 weeks PCA, and term infants <3 months admitted overnight after inguinal hernia repair, from January 2011 to December 2015 in a large tertiary children's hospital...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29643070/neurobehavioral-outcomes-11-years-after-neonatal-caffeine-therapy-for-apnea-of-prematurity
#6
Ines M Mürner-Lavanchy, Lex W Doyle, Barbara Schmidt, Robin S Roberts, Elizabeth V Asztalos, Lorrie Costantini, Peter G Davis, Deborah Dewey, Judy D'Ilario, Ruth E Grunau, Diane Moddemann, Harvey Nelson, Arne Ohlsson, Alfonso Solimano, Win Tin, Peter J Anderson
BACKGROUND AND OBJECTIVES: Caffeine is effective in the treatment of apnea of prematurity. Although caffeine therapy has a benefit on gross motor skills in school-aged children, effects on neurobehavioral outcomes are not fully understood. We aimed to investigate effects of neonatal caffeine therapy in very low birth weight (500-1250 g) infants on neurobehavioral outcomes in 11-year-old participants of the Caffeine for Apnea of Prematurity trial. METHODS: Thirteen academic hospitals in Canada, Australia, Great Britain, and Sweden participated in this part of the 11-year follow-up of the double-blind, randomized, placebo-controlled trial...
April 11, 2018: Pediatrics
https://www.readbyqxmd.com/read/29624144/pilot-study-of-intracranial-venous-physiology-in-craniosynostosis
#7
Martijn J Cornelissen, Robbin de Goederen, Priya Doerga, Iris Cuperus, Marie-Lise van Veelen, Maarten Lequin, Paul Govaert, Irene M J Mathijssen, Jeroen Dudink, Robert C Tasker
OBJECTIVE In addition to craniocerebral disproportion, other factors, such as Chiari malformation type I, obstructive sleep apnea, and venous outflow obstruction, are considered to have a role in the occurrence of intracranial hypertension in craniosynostosis. This pilot study examined cerebral venous flow velocity to better characterize the complex intracranial venous physiology of craniosynostosis. METHODS The authors performed a prospective cohort study of craniosynostosis patients (n = 34) referred to a single national (tertiary) craniofacial unit...
April 6, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29623136/the-effects-of-continuous-positive-airway-pressure-on-premature-ventricular-contractions-and-ventricular-wall-stress-in-patients-with-heart-failure-and-sleep-apnea
#8
Sabri Seyis, Adnan Kazım Usalan, Ibrahim Rencuzogullari, Özge Kurmuş, Adil Can Gungen
Background: We aimed to investigate the effects of continuous positive airway pressure (CPAP) treatment on electrocardiography (ECG), premature ventricular contraction load on 24-hour Holter recordings, and implantable cardioverter defibrillator (ICD) shocks in patients with obstructive sleep apnea syndrome (OSAS) and heart failure. Methods: Patients with heart failure and ICD and patients with newly diagnosed OSAS were divided into two groups according to CPAP treatment...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29606108/prevalence-and-risk-factors-of-retinopathy-of-prematurity-in-iran-a-systematic-review-and-meta-analysis
#9
Milad Azami, Zahra Jaafari, Shoboo Rahmati, Afsar Dastjani Farahani, Gholamreza Badfar
BACKGROUND: Retinopathy of prematurity (ROP) refers to the developmental disorder of the retina in premature infants and is one of the most serious and most dangerous complications in premature infants. The prevalence of ROP in Iran is different in various parts of Iran and its prevalence is reported to be 1-70% in different regions. This study aims to determine the prevalence and risk factors of ROP in Iran. METHODS: This review article was conducted based on the preferred reporting items for systematic review and meta-analysis (PRISMA) protocols...
April 2, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29593226/caffeine-augments-anesthesia-neurotoxicity-in-the-fetal-macaque-brain
#10
Kevin K Noguchi, Stephen A Johnson, Francesca M Manzella, Kobe L Masuoka, Sasha L Williams, Lauren D Martin, Gregory A Dissen, Chrysanthy Ikonomidou, Katie J Schenning, John W Olney, Ansgar M Brambrink
Caffeine is the most frequently used medication in premature infants. It is the respiratory stimulant of choice for apnea associated with prematurity and has been called the silver bullet in neonatology because of many proven benefits and few known risks. Research has revealed that sedative/anesthetic drugs trigger apoptotic death of neurons and oligodendrocytes in developing mammalian brains. Here we evaluated the influence of caffeine on the neurotoxicity of anesthesia in developing nonhuman primate brains...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29588331/predictors-of-prolonged-length-of-hospital-stay-for-infants-with-bronchiolitis
#11
Carlos E Rodríguez-Martínez, Monica P Sossa-Briceño, Gustavo Nino
Among inpatients suffering from bronchiolitis, approximately a quarter may undergo a prolonged length of stay (LOS) for the treatment of their respiratory condition. However, there have been few research studies that have evaluated variables that may be associated with a prolonged LOS in these patients, especially in low-income and middle-income countries, where the clinical and economic burden of the disease is the greatest. In an analytical single-center cross-sectional study, we included a population of patients with acute bronchiolitis hospitalized between March and June 2016...
March 26, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29552548/effect-of-tactile-stimulation-on-termination-and-prevention-of-apnea-of-prematurity-a-systematic-review
#12
Sophie J E Cramer, Janneke Dekker, Jenny Dankelman, Steffen C Pauws, Stuart B Hooper, Arjan B Te Pas
Apnea of prematurity (AOP) is one of the most common diagnoses in preterm infants. Severe and recurrent apneas are associated with cerebral injury and adverse neurodevelopmental outcome. Despite pharmacotherapy and respiratory support to prevent apneas, a proportion of infants continue to have apneas and often need tactile stimulation, mask, and bag ventilation and/or extra oxygen. The duration of the apnea and the concomitant hypoxia and bradycardia depends on the response time of the nurse. We systematically reviewed the literature with the aim of providing an overview of what is known about the effect of manual and mechanical tactile stimulation on AOP...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29544675/-peribulbar-block-combined-with-general-anesthesia-in-babies-undergoing-laser-treatment-for-retinopathy-of-prematurity-a-retrospective-analysis
#13
Daniela Filipa Rodrigues Pinho, Cátia Real, Leónia Ferreira, Pedro Pina
BACKGROUND AND OBJECTIVES: Currently there is no agreement regarding which one is the most adequate anesthetic technique for the treatment of retinopathy of prematurity. Peribulbar block may reduce the incidence of oculocardiac reflex and postoperative apnea. The goal of this study was to report the outcomes of peribulbar block, when combined with general anesthesia, for the laser treatment for retinopathy of prematurity, in premature babies. METHODS: A retrospective analysis of anesthetic records of all babies who underwent laser treatment for retinopathy of prematurity from January 2008 through December 2015 in a tertiary hospital was performed...
March 12, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29515224/blood-potassium-and-urine-aldosterone-after-doxapram-therapy-for-preterm-infants
#14
Tomoyuki Shimokaze, Katsuaki Toyoshima, Jun Shibasaki, Yasufumi Itani
OBJECTIVE: We often encounter infants who developed hypokalaemia following low-dose doxapram for apnea of prematurity (AOP). AIMS: To determine changes in blood potassium (K+) levels after doxapram administration. STUDY DESIGN: We studied infants born before 30 weeks gestation. Doxapram (0.1-0.3 mg/kg/h) in addition to methylxanthines was used to treat AOP refractory to methylxanthines. RESULTS: Twenty-five infants received doxapram were studied...
March 7, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29410745/prevalence-and-predictors-of-arrhythmia-in-patients-with-obstructive-sleep-apnea
#15
Aljohara Saud Almeneessier, Nader Alasousi, Munir M Sharif, Seithikurippu R Pandi-Perumal, Ahmad Salah Hersi, Ahmed Salem BaHammam
Objectives: To assess the prevalence and types of arrhythmias in Saudi OSA patients and to identify predictors of arrhythmia in this group of patients. Methods: This case-control study included all patients who underwent level I attended overnight polysomnography between 2009 and 2012. Electrocardiographic data collected during sleep studies of patients with and without OSA were manually reviewed. Results: The study comprised 498 patients (394 OSA patients and 104 non-OSA patients (controls)...
October 2017: Sleep Science
https://www.readbyqxmd.com/read/29392321/retinopathy-of-prematurity-among-very-low-birth-weight-infants-in-china-incidence-and-perinatal-risk-factors
#16
Tian Wu, Li Zhang, Yu Tong, Yi Qu, Bin Xia, Dezhi Mu
Purpose: Retinopathy of prematurity (ROP) is the leading cause of blindness in children worldwide. This study aimed to determine the incidence and perinatal risk factors for ROP in very low-birth-weight (VLBW) Chinese infants. Methods: A retrospective study of the medical records of 504 VLBW infants screened for ROP from 2012 to 2015 was performed in West China Second University Hospital. VLBW infants were examined according to the Royal College of Ophthalmologists ROP guideline and retinopathy was graded following the International Classification of ROP...
February 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29387319/the-efficacy-and-safety-of-two-different-doses-of-caffeine-in-respiratory-function-of-preterm-infants
#17
Fatemeh Faramarzi, Mohammadreza Shiran, Mohammadreza Rafati, Roya Farhadi, Ebrahim Salehifar, Maryam Nakhshab
Background: Caffeine is widely used for prevention of apnea and helps successful extubation from mechanical ventilation. It facilitates the transition from invasive to noninvasive support and reduces duration of continuous positive airway pressure (CPAP) in preterm infants. The optimum caffeine dose in preterm infants has not been well-studied in terms of benefits and risks. We compared efficacy and safety of once versus twice-daily caffeine dose in premature infants. Methods: This study was a randomized clinical trial conducted in Bu-Ali Sina Teaching Hospital, Sari...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29386437/-comparative-study-of-the-efficacy-and-safety-of-caffeine-and-aminophylline-for-the-treatment-of-apnea-in-preterm-infants
#18
COMPARATIVE STUDY
Akane Nagasato, Masatoshi Nakamura, Hidetoshi Kamimura
 Methylxanthine is widely administered for the treatment of apnea of prematurity in many countries, and previous reports have clearly established that caffeine is effective for the treatment of apnea of prematurity. In Japan, caffeine has been available since December 2014. Thus, we compared the efficacy and safety of caffeine with that of aminophylline in our hospital. There was no significant difference between the caffeine group and aminophylline group regarding the characteristics of the study patients...
2018: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/29357829/caffeine-is-a-risk-factor-for-osteopenia-of-prematurity-in-preterm-infants-a-cohort-study
#19
Ebtihal Ali, Cheryl Rockman-Greenberg, Michael Moffatt, Michael Narvey, Martin Reed, Depeng Jiang
BACKGROUND: Caffeine, the most commonly used medication in Neonatal Intensive Care Units, has calciuric and osteoclastogenic effects. METHODS: To examine the association between the cumulative dose and duration of therapy of caffeine and osteopenia of prematurity, a retrospective cohort study was conducted including premature infants less than 31 weeks and birth weight less than 1500 g. Osteopenia of prematurity was evaluated using chest X-rays on a biweekly basis over 12 weeks of hospitalization...
January 22, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29346141/caffeine-controversies
#20
Samuel J Gentle, Colm P Travers, Waldemar A Carlo
PURPOSE OF REVIEW: Caffeine use in preterm infants has endured several paradigms: from standard of care to possible neurotoxin to one of the few medications for which there is evidence of bronchopulmonary dysplasia (BPD) risk reduction. The purpose of the review is to analyze this dynamic trajectory and discuss controversies that still remain after decades of caffeine use. RECENT FINDINGS: Following concerns for caffeine safety in preterm infants, a large randomized controlled trial demonstrated a reduction in BPD and treatment for patent ductus arteriosus...
April 2018: Current Opinion in Pediatrics
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