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William J Hammond, Benjamin A Farber, Anita P Price, Suzanne L Wolden, Todd E Heaton, Leonard H Wexler, Michael P La Quaglia
PURPOSE: To evaluate factors associated with progression-free and disease-specific survival in patients with paratesticular rhabdomyosarcoma, we performed a cohort study. Also, since many patients present to our institution after initial therapy, we analyzed the effects of salvage therapy for scrotal violation. PATIENTS AND METHODS: We retrospectively reviewed the records of all consecutive patients with histologically confirmed paratesticular rhabdomyosarcoma treated at our institution between 1978 and 2015...
November 14, 2016: Journal of Pediatric Surgery
Guido Seitz, Jörg Fuchs, Peter Martus, Thomas Klingebiel, Ivo Leuschner, Andreas Schuck, Tobias M Dantonello, Ewa Koscielniak
OBJECTIVE: To evaluate outcome in respect to local treatment strategies in 4 prospective CWS trials in patients with paratesticular rhabdomyosarcoma (PTRMS). SUMMARY BACKGROUND DATA: PTRMS patients have a high number of surgical treatment failures. Retroperitoneal lymph node (LN) involvement is common in patients more than 10 years, and the optimal treatment is unknown. METHODS: A total of 173 patients with diagnosis of PTRMS were enrolled...
December 2016: Annals of Surgery
Sarah J Lowry, Noel S Weiss
PURPOSE: Exposure to asbestos is thought to cause the large majority of pleural mesotheliomas in the USA. It is unknown whether asbestos exposure plays a role in the etiology of rarer forms of mesothelioma, e.g., those located in the pericardium or in the tunica vaginalis of the testis. In order to address this question, we sought to determine whether geographic patterns of incidence of these mesotheliomas have paralleled those of pleural mesotheliomas. METHODS: We used age-adjusted incidence data from the nine populations served by the National Cancer Institute's Surveillance, Epidemiology, and End Results program during 1973-2011...
November 3, 2016: Cancer Causes & Control: CCC
J Rojas-Ticona, M Fernández-Ibieta, L Nortes Cano, O Girón-Vallejo, P Reyes Ríos, I Martínez Castaño, V Villamil, J I Ruiz Jiménez
OBJECTIVES: To describe our experience in testicular and paratesticular tumors during the prepubertal stage, focusing especially on its character of benignity/malignancy and surgical treatment used. MATERIAL AND METHODS: Retrospective review of all testicular tumors in children under 12 years diagnosed and treated in our clinical setting from 1998-2015. Data on their presentation, study and management were collected. RESULTS: 17 children with prepubertal testicular tumors were identified...
April 15, 2015: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
David Guard, Benjamin Shepherd
No abstract text is available yet for this article.
February 2016: Pathology
B Mrinakova, K Kajo, M Ondrusova, J Simo, D Ondrus
Paratesticular malignant mesothelioma is an extremely rare type of mesothelioma with only a limited number of reported cases. Its clinical differentiation is challenging, and its diagnosis is almost exclusively accidental. The major risk factor is exposure to asbestos, typically with a long latency between exposure and diagnosis. The current study presents the clinical data of two patients diagnosed with paratesticular malignant mesothelioma. We evaluated a large spectrum of risk factors in the patients histories...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
M Marcou, V Perst, C Cacchi, M Lehnhardt, T-A Vögeli
Physicians will be rarely confronted with epididymal tumours. These represent only 5% of intrascrotal tumours and are mostly (75%) benign. We report the case of a 50-year-old white male who was presented with a 5-year history of a slow-growing, left scrotal mass, noted through self-examination. Ultrasound study of the scrotum identified a well-circumscribed paratesticular mass. On inguinal surgical exploration, a solid, encapsulated, grey-white mass at the tail of the left epididymis was identified and excised, with intra-operative pathological consultation showing no signs of malignancy...
October 6, 2016: Andrologia
Raquel Sopeña-Sutil, Francesco Silan, Maria Teresa Butron-Vila, Felix Guerrero-Ramos, Emilio Lagaron-Comba, Juan Passas-Martinez
Primary paratesticular tumours are very rare and the spermatic cord (SCT) is the most frequent site of origin, with 20% of malignancy. Although liposarcoma is the most frequent histotype (46.6 %), less than 200 cases have been reported in the literature. We report the case of a 56-year-old man who presented a giant scrotal mass of 25 years of evolution and measuring 40 × 40 cm. It could be considered the greatest paratesticular liposarcoma described to date. Computed tomogaphy (CT) revealed mass features consistent with liposarcoma and the simultaneous presence of bilateral inguinal hernia with bladder involvement...
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Neriman Sarı, Nurettin Okur, Gulin Uçmak, İnci Ergürhan İlhan
We report a 16-year-old male patient diagnosed with paratesticular rhabdomyosarcoma and mediastinal tuberculous lymphadenitis. The differential diagnosis between high or early stage of rhabdomyosarcoma and tuberculosis (TB) was critical in this patient without a history of TB. Unexpected lymphadenopathies detected during the staging of patients with malignancy should be carefully evaluated, and TB should be taken into consideration in the differential diagnosis especially in underdeveloped and developing countries...
September 28, 2016: Journal of Tropical Pediatrics
Harnam Singh Rekhi, Sushil Kumar Mittal, Srinath Reddy Mannem, Sahil Arora, Kaushal Seth, Sathya Pakkiri, Ravitej Singh, Saryu Gupta, Manoj Mathur
A 20-day-old boy was presented with left scrotal swelling, clinically diagnosed as hydrocele. Ultrasonographic findings suggested hydrocele with paratesticular mass. Intraoperatively we found paratesticular mass, separate from left testis. Specimen revealed fibroconnective tissue with mucoid degeneration and focal areas of calcification suggesting meconium periorchitis. It is important to consider meconium periorchitis as one of the etiologies, thereby avoiding unnecessary orchidectomies.
September 2016: Clinical Case Reports
Inna Lobeck, Phylicia Dupree, Rebekah Karns, David Rodeberg, Daniel von Allmen, Roshni Dasgupta
BACKGROUND: Lymph node sampling is integral in the management of extremity and paratesticular rhabdomyosarcoma (RMS). The aim of this study was to determine overall surgical compliance with treatment protocols and impact of nodal sampling outcomes in these tumors. METHODS: A query of the surveillance, epidemiology, and end results program (SEER) database was performed from 2003 to 2008 for patients <19years of age with RMS. Data obtained included demographics, five-year survival and rate of nodal sampling...
September 2, 2016: Journal of Pediatric Surgery
Derfel Ap Dafydd, Christina Messiou, Khin Thway, Dirk C Strauss, David L Nicol, Eleanor Moskovic
OBJECTIVE: To describe the major imaging features, together with clinical data, of paratesticular sarcomas. METHODS: A retrospective analysis was performed of available imaging and clinical data of 77 consecutive cases of paratesticular sarcoma referred to the soft tissue sarcoma centre at **BLINDED**, between January 2006 and January 2015. RESULTS: Of the total cases, 87% had been referred post-operatively, 43% of which had been imaged pre-operatively and 24% of which required re-resection due to incomplete initial excision...
September 14, 2016: Urology
Manuel Nistal, Ricardo Paniagua, Pilar Gonzalez-Peramato, Miguel Reyes-Múgica
Testicular tumors in the prepubertal age are relatively rare, representing only 9.4% of the total testicular and paratesticular specimens from a 20 year review performed at a large pediatric hospital 1. They account for 1 to 2 % of all solid tumors in the pediatric age group, with an annual incidence between 0.5 and 2/100,000 boys according to Coppes et al. 2 and data from the Prepubertal Testicular Tumor Registry 3. Similar to other neoplasms afflicting children, a bimodal age distribution is observed. The first peak is between birth and 3 years of age, and a second one occurs at the onset of puberty,extending to the fourth decade...
September 14, 2016: Pediatric and Developmental Pathology
Bharat Rekhi, Pawan Upadhyay, Manoj P Ramteke, Amit Dutt
Recurrent mutations in the myogenic transcription factor MYOD1 and PIK3CA were initially described in a subset of embryonal rhabdomyosarcomas. Recently, two independent studies demonstrated presence of MYODI (L122R) mutations as the basis to re-classify a spindle cell rhabdomyosarcoma, along with a sclerosing rhabdomyosarcoma, distinct from an embryonal rhabdomyosarcoma. We analyzed a much larger cohort of 49 primary rhabdomyosarcoma tumor samples of various subtypes, collected over a period of 9 years, for the presence of MYOD1 (L122R), PIK3CA (H1047), and PIK3CA (E542/E545) mutations, along with immunohistochemical analysis of desmin, myogenin, and MYOD1...
August 26, 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Refky Nicola, Christine O Menias, Nirvikar Dahiya, Kathryn Robinson, Amy K Hara, Cary Lynn Siegel
The paratesticular scrotal contents consist of the spermatic cord, epididymis, and fascia, which originate from the embryologic descent of the testis through the abdominal wall. Historically, the primary diagnostic modality has been high-resolution ultrasound. Magnetic resonance imaging (MRI) is an alternative imaging option. Both contrast MRI and diffusion weighted imaging can assist in differentiating between benign and malignant lesions. Unlike the testis which most disease processes are malignant, a wide spectrum of benign disease processes affects the paratesticular region either in isolation or as part of a contiguous disease process from adjacent organs...
August 17, 2016: Abdominal Radiology
Preeti Rihal Chakrabarti, Shilpi Dosi, Amit Varma, Priyanka Kiyawat, Gaurav Khare, Sandeep Matreja
INTRODUCTION: Testicular and para-testicular neoplasm are rare type of tumours affecting adolescents and young adults, reflected by the paucity of published data in India. AIM: This study was undertaken to estimate the epidemiological characteristics and histological types and subtypes of testicular neoplasm according to the WHO classification in our patient group. Identification of histopathological pattern of testicular tumour is immensely important for improved management protocols...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Sonam Mahana, Reena Tomar, Anil Agarwal, Divya Sharma, Nita Khurana, Ruchika Gupta
Spindle-cell rhabdomyosarcoma (RMS) is a relatively recently recognized favorable variant of embryonal RMS occurring mainly in the paratesticular and head and neck regions. Cytological reports of spindle-cell RMS have been sparse in the literature and the awareness of its cytological features is not very wide among cytopathologists. A 2-year-old girl was brought to clinical attention for a progressively enlarging swelling of right thumb. Imaging studies showed it to be a soft-tissue tumor in the subcutaneous region...
December 2016: Diagnostic Cytopathology
Ali Kord Valeshabad, Anne Walsh, Granville L Lloyd
Spermatic cord malignancy is a rare and challenging diagnosis, often misdiagnosed as an inguinal hernia or cord lipoma. In these images, we show a 61-year-old male for whom laparoscopic repair of clinically diagnosed hernia was attempted. Laparoscopy revealed closed internal ring without hernia. Imaging showed large paratesticular mass; radical inguinal excision of testicle, cord, and mass was performed. Pathology showed mixed low-grade and high-grade sarcoma. Liposarcoma should be considered in cases of unusual inguinal mass; appropriate imaging can guide surgical approach and optimize outcomes...
August 5, 2016: Urology
Renate Pichler, Gennadi Tulchiner, Friedrich Aigner, Wolfgang Horninger, Isabel Heidegger
No abstract text is available yet for this article.
June 29, 2016: Clinical Genitourinary Cancer
Sadi Turkan, Mehmet Kalkan, Ozan Ekmekcioglu, Hacer Haltas, Coskun Sahin
Paratesticular fibrous pseudotumors (PFPs) are rare pathologies with quite wide and variable topographic-morphological features. It is difficult to distinguish PFPs from malignant masses. Treatment can be done by resection of the mass. We reported a young patient's findings about this rare pathology.
June 28, 2016: Rare Tumors
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