Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Yizeng Xu, Fang Lu, Meng Wang, Lingchen Wang, Chaoyang Ye, Shuohui Yang, Chen Wang
Background: Renal hypoxia plays a key role in the progression of chronic kidney disease (CKD). Shen Shuai II Recipe (SSR) has shown good results in the treatment of CKD as a common herbal formula. This study aimed to explore the effect of SSR on renal hypoxia and injury in CKD rats. Methods: Twenty-five Wistar rats underwent 5/6 renal ablation/infarction (A/I) surgery were randomly divided into three groups: 5/6 (A/I), 5/6 (A/I) + losartan (LOS), and 5/6 (A/I) + SSR groups. Another eight normal rats were used as the Sham group...
December 2024: Renal Failure
#22
JOURNAL ARTICLE
Jinxia Liu, Jane MacNaughtan, Annarein J C Kerbert, Theo Portlock, Javier Martínez Gonzalez, Yi Jin, Frederick Clasen, Abeba Habtesion, Huoyan Ji, Qin Jin, Alexandra Phillips, Francesco De Chiara, Ganesh Ingavle, Cesar Jimenez, Giacomo Zaccherini, Katherine Husi, Miguel Angel Rodriguez Gandia, Paul Cordero, Junpei Soeda, Lynda McConaghy, Jude Oben, Karen Church, Jia V Li, Haifeng Wu, Aarti Jalan, Pere Gines, Elsa Solà, Simon Eaton, Carrie Morgan, Michal Kowalski, Daniel Green, Amir Gander, Lindsey A Edwards, I Jane Cox, Helena Cortez-Pinto, Thomas Avery, Reiner Wiest, Francois Durand, Paolo Caraceni, Roberto Elosua, Joan Vila, Marco Pavesi, Vicente Arroyo, Nathan Davies, Rajeshwar P Mookerjee, Victor Vargas, Susan Sandeman, Gautam Mehta, Saeed Shoaie, Julian Marchesi, Agustín Albillos, Fausto Andreola, Rajiv Jalan
OBJECTIVE: Targeting bacterial translocation in cirrhosis is limited to antibiotics with risk of antimicrobial resistance. This study explored the therapeutic potential of a non-absorbable, gut-restricted, engineered carbon bead adsorbent, Yaq-001 in models of cirrhosis and acute-on-chronic liver failure (ACLF) and, its safety and tolerability in a clinical trial in cirrhosis. DESIGN: Performance of Yaq-001 was evaluated in vitro . Two-rat models of cirrhosis and ACLF, (4 weeks, bile duct ligation with or without lipopolysaccharide), receiving Yaq-001 for 2 weeks; and two-mouse models of cirrhosis (6-week and 12-week carbon tetrachloride (CCl4)) receiving Yaq-001 for 6 weeks were studied...
April 15, 2024: Gut
#23
JOURNAL ARTICLE
Makoto Yamaguchi, Hirokazu Sugiyama, Akimasa Asai, Fumiya Kitamura, Hironobu Nobata, Hiroshi Kinashi, Takayuki Katsuno, Shogo Banno, Yasuhiko Ito, Takahiro Imaizumi, Masahiko Ando, Yoko Kubo, Maeda Keisuke, Yuria Ishida, Naoharu Mori, Takuji Ishimoto
OBJECTIVE: The clinical impact of malnutrition based on the Global Leadership Initiative on Malnutrition (GLIM) criteria in patients with kidney dysfunction remains poorly understood. This study investigated the usefulness of GLIM criteria for malnutrition predicting mortality in patients with kidney dysfunction and different clinical renal states, including no kidney disease (NKD), acute kidney injury (AKI), and chronic kidney disease (CKD). METHODS: This single-center retrospective cohort study included 6,712 patients aged ≥18 admitted between 2018 and 2019...
April 13, 2024: Journal of Renal Nutrition
#24
JOURNAL ARTICLE
Balagangadhar R Totapally, Seevitha Totapalli, Prithvi Sendi, Paul A Martinez
OBJECTIVE: The study aimed to explore the prevalence, clinical features, resource utilization, temporal trends and outcomes associated with adenoviral infections in hospitalized children. METHODS: A retrospective analysis using the Healthcare Cost and Utilization Project's Kids' Inpatient Database from 1997 to 2019 was performed. Children aged 29 days to 17 years with adenoviral infection were selected. Chi-square, Kruskal-Wallis tests, linear trend analysis and multivariable analysis were used for data analysis...
April 11, 2024: Pediatric Infectious Disease Journal
#25
REVIEW
Racquel Lowe-Jones, Isabelle Ethier, Lori-Ann Fisher, Michelle M Y Wong, Stephanie Thompson, Georges Nakhoul, Shaifali Sandal, Rahul Chanchlani, Sara N Davison, Anukul Ghimire, Kailash Jindal, Mohamed A Osman, Parnian Riaz, Syed Saad, Stephen M Sozio, Somkanya Tungsanga, Alexandra Cambier, Silvia Arruebo, Aminu K Bello, Fergus J Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G Okpechi, Marcello Tonelli, Feng Ye, Rulan S Parekh, Shuchi Anand
The International Society of Nephrology Global Kidney Health Atlas charts the availability and capacity of kidney care globally. In the North America and the Caribbean region, the Atlas can identify opportunities for kidney care improvement, particularly in Caribbean countries where structures for systematic data collection are lacking. In this third iteration, respondents from 12 of 18 countries from the region reported a 2-fold higher than global median prevalence of dialysis and transplantation, and a 3-fold higher than global median prevalence of dialysis centers...
April 2024: Kidney International Supplements
#26
REVIEW
Maria Pippias, Gaetano Alfano, Dearbhla M Kelly, Maria Jose Soler, Letizia De Chiara, Timothy O Olanrewaju, Silvia Arruebo, Aminu K Bello, Fergus J Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G Okpechi, Marcello Tonelli, Feng Ye, Rosanna Coppo, Liz Lightstone
Western Europe boasts advanced health care systems, robust kidney care guidelines, and a well-established health care workforce. Despite this, significant disparities in kidney replacement therapy incidence, prevalence, and transplant access exist. This paper presents the third International Society of Nephrology Global Kidney Health Atlas's findings on kidney care availability, accessibility, affordability, and quality in 22 Western European countries, representing 99% of the region's population. The known chronic kidney disease (CKD) prevalence across Western Europe averages 10...
April 2024: Kidney International Supplements
#27
REVIEW
Viviane Calice-Silva, Javier A Neyra, Alejandro Ferreiro Fuentes, Krissia Kamile Singer Wallbach Massai, Silvia Arruebo, Aminu K Bello, Fergus J Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G Okpechi, Marcello Tonelli, Feng Ye, Magdalena Madero, Carmen Tzanno Martins
Successful management of chronic kidney disease (CKD) in Latin America (LA) continues to represent a challenge due to high disease burden and geographic disparities and difficulties in terms of capacity, accessibility, equity, and quality of kidney failure care. Although LA has experienced significant social and economic progress over the past decades, there are still important inequities in health care access. Through this third iteration of the International Society of Nephrology Global Kidney Health Atlas, the indicators regarding kidney failure care in LA are updated...
April 2024: Kidney International Supplements
#28
REVIEW
Larisa Prikhodina, Kirill Komissarov, Nikolay Bulanov, Silvia Arruebo, Aminu K Bello, Fergus J Caskey, Sandrine Damster, Jo-Ann Donner, Vivekanand Jha, David W Johnson, Adeera Levin, Charu Malik, Masaomi Nangaku, Ikechi G Okpechi, Marcello Tonelli, Feng Ye, Abduzhappar Gaipov
The International Society of Nephrology Global Kidney Health Atlas (ISN-GKHA) was established to aid understanding of the status and capacity of countries to provide optimal kidney care worldwide. This report presents the current characteristics of kidney care in the ISN Newly Independent States (NIS) and Russia region. Although the median prevalence of chronic kidney disease (CKD) was higher (11.4%) than the global median (9.5%), the median CKD-related death rate (1.4%) and prevalence of treated kidney failure (KF) in the region (411 per million population [pmp]) were lower than they are globally (2...
April 2024: Kidney International Supplements
#29
Sunny Malde, Pranjal Kashiv, Sushrut Gupta, Shubham Dubey, Manish Balwani, Amit Pasari, Kapil N Sejpal, Prasad Gurjar
This case report details a 62-year-old male with a history of right renal cell carcinoma (RCC) who developed sunitinib-induced nephrotic syndrome during treatment. The patient had a complex medical history, including a right nephrectomy in 2009, brain metastasis excisions in 2011 and 2012, and prolonged sunitinib therapy. Hypothyroidism, hypertension, and various surgeries further complicated his clinical picture. In April 2022, the patient presented with bilateral pedal edema, acute kidney injury superimposed on chronic kidney disease, and proteinuria...
March 2024: Curēus
#30
JOURNAL ARTICLE
Yuan Tian, Jiongcheng Chen, Wenshu Huang, Qian Ren, Junxia Feng, Jinlin Liao, Haiyan Fu, Lili Zhou, Youhua Liu
Wnt/β-catenin signaling plays a pivotal role in the pathogenesis of chronic kidney diseases (CKD), which is associated with macrophage activation and polarization. However, the relative contribution of macrophage-derived Wnts in the evolution of CKD is poorly understood. Here we demonstrate a critical role of Wnts secreted by macrophages in regulating renal inflammation and fibrosis after various injuries. In mouse model of kidney fibrosis induced by unilateral ureteral obstruction (UUO), macrophages were activated and polarized to M1 and M2 subtypes, which coincided with the activation of Wnt/β-catenin signaling...
2024: International Journal of Biological Sciences
#31
Yongqun Oliver He, Laura Barisoni, Avi Z Rosenberg, Peter Robinson, Alexander D Diehl, Yichao Chen, Jimmy P Phuong, Jens Hansen, Bruce W Herr, Katy Börner, Jennifer Schaub, Nikki Bonevich, Ghida Arnous, Saketh Boddapati, Jie Zheng, Fadhl Alakwaa, Pinaki Sarder, William D Duncan, Chen Liang, M Todd Valerius, Sanjay Jain, Ravi Iyengar, Jonathan Himmelfarb, Matthias Kretzler
Many data resources generate, process, store, or provide kidney related molecular, pathological, and clinical data. Reference ontologies offer an opportunity to support knowledge and data integration. The Kidney Precision Medicine Project (KPMP) team contributed to the representation and addition of 329 kidney phenotype terms to the Human Phenotype Ontology (HPO), and identified many subcategories of acute kidney injury (AKI) or chronic kidney disease (CKD). The Kidney Tissue Atlas Ontology (KTAO) imports and integrates kidney-related terms from existing ontologies (e...
April 2, 2024: bioRxiv
#32
JOURNAL ARTICLE
Paweł Wrona, Katarzyna Sawczyńska, Dominik Wróbel, Kaja Zdrojewska, Mateusz Giełczyński, Paweł Mizera, Paweł Brzegowy, Tadeusz Popiela, Agnieszka Słowik, Marcin Krzanowski
INTRODUCTION: Acute kidney injury (AKI) seems to worsen the prognosis of acute ischaemic stroke (AIS) patients treated with mechanical thrombectomy (MT). At the same time, the procedure of MT increases AKI risk by iodinated contrast use. Identification of factors predisposing to AKI after MT is important for recognizing vulnerable patients and successful prevention. AIM: To identify factors associated with the occurrence of AKI during hospitalization in MT-treated AIS patients...
March 2024: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
#33
JOURNAL ARTICLE
Mohammad Rezapour, Mohsen Yazdinejad, Faezeh Rajabi Kouchi, Masoomeh Habibi Baghi, Zahra Khorrami, Morteza Khavanin Zadeh, Elmira Pourbaghi, Hassan Rezapour
More than half of the world population lives in Asia and hypertension (HTN) is the most prevalent risk factor found in Asia. There are numerous articles published about HTN in Eastern Mediterranean Region (EMRO) and artificial intelligence (AI) methods can analyze articles and extract top trends in each country. Present analysis uses Latent Dirichlet allocation (LDA) as an algorithm of topic modeling (TM) in text mining, to obtain subjective topic-word distribution from the 2790 studies over the EMRO. The period of checked studied is last 12 years and results of LDA analyses show that HTN researches published in EMRO discuss on changes in BP and the factors affecting it...
December 2024: Renal Failure
#34
JOURNAL ARTICLE
Chariclia Paradissis, Neil Cottrell, Ian D Coombes, William Y S Wang, Michael A Barras
Introduction The contribution of medication harm to rehospitalisation and adverse patient outcomes after an acute myocardial infarction (AMI) needs exploration. Rehospitalisation is costly to both patients and the healthcare facility. Following an AMI, patients are at risk of medication harm as they are often older, have multiple comorbidities and polypharmacy. This study aimed to quantify and evaluate medication harm causing unplanned rehospitalisation after an AMI. Methods This was a retrospective cohort study of patients discharged from a quaternary hospital post-AMI...
April 12, 2024: Cardiology
#35
REVIEW
Lauren E Lee, Tomohito Doke, Dhanunjay Mukhi, Katalin Susztak
Kidney epithelial cells have very high energy requirements, which are largely met by fatty acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney disease. Defects in fatty acid oxidation and increased lipid uptake, especially in the context of hyperlipidemia and proteinuria, contribute to this excess lipid build-up and exacerbate kidney disease development. Recent studies have also highlighted the role of increased de novo lipogenesis in kidney fibrosis. The defect in fatty acid oxidation will cause energy starvation...
April 11, 2024: Kidney International
#36
REVIEW
Lara Fabiana Luz Malheiro, Mariana Masimessi Fernandes, Caroline Assunção Oliveira, Isadora de Souza Barcelos, Ana Jullie Veiga Fernandes, Bruna Santos Silva, Júlia Spínola Ávila, Telma de Jesus Soares, Liliany Souza de Brito Amaral
Regular exercise training can lead to several health benefits, reduce mortality risk, and increase life expectancy. On the other hand, a sedentary lifestyle is a known risk factor for chronic diseases and increased mortality. Acute kidney injury (AKI) and chronic kidney disease (CKD) represent a significant global health problem, affecting millions of people worldwide. The progression from AKI to CKD is well-recognized in the literature, and exercise training has emerged as a potential renoprotective strategy...
April 11, 2024: Life Sciences
#37
REVIEW
Zengyu Xun, Tianqi Li, Xue Xue
Liposomes-microscopic phospholipid bubbles with bilayered membrane structure-have been a focal point in drug delivery research for the past 30 years. Current liposomes possess a blend of biocompatibility, drug loading efficiency, prolonged circulation and targeted delivery. Tailored liposomes, varying in size, charge, lipid composition, and ratio, have been developed to address diseases in specific organs, thereby enhancing drug circulation, accumulation at lesion sites, intracellular delivery, and treatment efficacy for various organ-specific diseases...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
#38
REVIEW
Vi Nguyen, Elaine G Taine, Dehao Meng, Taixing Cui, Wenbin Tan
Chlorogenic acid (CGA) is a type of polyphenol compound found in rich concentrations in many plants such as green coffee beans. As an active natural substance, CGA exerts diverse therapeutic effects in response to a variety of pathological challenges, particularly conditions associated with chronic metabolic diseases and age-related disorders. It shows multidimensional functions, including neuroprotection for neurodegenerative disorders and diabetic peripheral neuropathy, anti-inflammation, anti-oxidation, anti-pathogens, mitigation of cardiovascular disorders, skin diseases, diabetes mellitus, liver and kidney injuries, and anti-tumor activities...
March 23, 2024: Nutrients
#39
REVIEW
Alessio Mazzieri, Francesca Porcellati, Francesca Timio, Gianpaolo Reboldi
Diabetic kidney disease (DKD) is a chronic microvascular complication in patients with diabetes mellitus (DM) and the leading cause of end-stage kidney disease (ESKD). Although glomerulosclerosis, tubular injury and interstitial fibrosis are typical damages of DKD, the interplay of different processes (metabolic factors, oxidative stress, inflammatory pathway, fibrotic signaling, and hemodynamic mechanisms) appears to drive the onset and progression of DKD. A growing understanding of the pathogenetic mechanisms, and the development of new therapeutics, is opening the way for a new era of nephroprotection based on precision-medicine approaches...
April 3, 2024: International Journal of Molecular Sciences
#40
JOURNAL ARTICLE
Giulia Nardi, Enrico Marchi, Marco Allinovi, Gianmarco Lugli, Lucrezia Biagiotti, Francesca Maria Di Muro, Renato Valenti, Iacopo Muraca, Benedetta Tomberli, Niccolò Ciardetti, Brunetto Alterini, Francesco Meucci, Carlo Di Mario, Alessio Mattesini
(1) Background : This single-center retrospective study aimed to evaluate whether sodium-glucose cotransporter-2 inhibitors (SGLT2-i) therapy may have a nephroprotective effect to prevent contrast-induced acute kidney injury (CI-AKI) in patients with heart failure (HF) undergoing iodinated contrast medium (ICM) invasive procedures. (2) Methods : The population was stratified into SGLT2-i users and SGLT2-i non-users according to the chronic treatment with gliflozins. The primary endpoint was CI-AKI incidence during hospitalization...
April 1, 2024: Journal of Clinical Medicine
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
