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JOURNAL ARTICLE
Liang Tan, Feilong Wang, Yi Huang, Chuhua Fu, Haijun Zhang, Jianfei Feng, Yincai Xu, Xinzhen Ye, Rongrui Tang, Yinglian Chen, Liansheng Mou, Ronghao Li, Jingyu Chen, Jishu Xian
PURPOSE: The SARS-CoV-2 infection cases are increasing rapidly in neuro-intensive care units (neuro-ICUs) at the beginning of 2023 in China. We aimed to characterize the prevalence, risk factors, and prognosis of critically ill patients treated in neuro-ICUs. MATERIALS AND METHODS: In the prospective, multicenter, observational registry study, critically ill patients with intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and traumatic brain injury (TBI) admitted to eight Chinese neuro-ICUs between Feb 16, 2023, to Apr 30, 2023 were enrolled for the study...
2024: Neuropsychiatric Disease and Treatment
#22
JOURNAL ARTICLE
Olanrewaju Edun, Lucy Okell, Helen Chun, Anne-Cecile Z Bissek, Clement B Ndongmo, Judith D Shang, Hermann Brou, Eboi Ehui, Alexandre K Ekra, Harriet Nuwagaba-Biribonwoha, Sindisiwe S Dlamini, Choice Ginindza, Frehywot Eshetu, Yimam G Misganie, Sileshi Lulseged Desta, Thomas N O Achia, Appolonia Aoko, Sasi Jonnalagadda, Rose Wafula, Fred M Asiimwe, Shirley Lecher, Kondwani Nkanaunena, Mtemwa K Nyangulu, Rose Nyirenda, Anita Beukes, Johannes O Klemens, Negussie Taffa, Andrew A Abutu, Matthias Alagi, Man E Charurat, Ibrahim Dalhatu, Gambo Aliyu, Collins Kamanzi, Celestine Nyagatare, Gallican N Rwibasira, Mohamed F Jalloh, Werner M Maokola, George S Mgomella, Wilford L Kirungi, Christina Mwangi, Jennifer A Nel, Peter A Minchella, Gloria Gonese, Melodie A Nasr, Stephane Bodika, Elisabeth Mungai, Hetal K Patel, Katrina Sleeman, Kyle Milligan, Emilio Dirlikov, Andrew C Voetsch, Ray W Shiraishi, Jeffrey W Imai-Eaton
As antiretroviral treatment (ART) coverage for people living with HIV (PLHIV) increases, HIV programmes require up-to-date information about evolving HIV risk behaviour and transmission risk, including those with low-level viremia (LLV; >50 to ≤1000 copies/mL), to guide prevention priorities. We aimed to assess differences in sexual risk behaviours, distribution of viral load (VL) and proportion of transmission across PLHIV subgroups. We analysed data from Population-based HIV Impact Assessment surveys in 14 sub-Saharan African countries during 2015-2019...
2024: PLOS Glob Public Health
#23
JOURNAL ARTICLE
Samantha M Forbes, Lesley A Tarasoff, Meredith Evans, Hilary K Brown
OBJECTIVES: Preconception health (PCH), which describes the health status of reproductive-aged individuals, can influence reproductive, maternal, and fetal/neonatal outcomes. PCH disparities have been observed in certain populations, prompting the development of tailored resources. Our objective was to compare the PCH characteristics of women with and without disabilities. METHODS: We undertook a secondary analysis of the 2003-2014 cycles of the Canadian Community Health Survey (CCHS), which included n = 115,295 women aged 15-49 years...
April 4, 2024: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
#24
JOURNAL ARTICLE
Ting Jiang, Qianlin Weng, Yuqing Zhang, Weiya Zhang, Michael Doherty, Aliya Sarmanova, Zidan Yang, Tuo Yang, Jiatian Li, Ke Liu, Yuqing Wang, Abasiama D Obotiba, Chao Zeng, Guanghua Lei, Jie Wei
OBJECTIVE: Although hand synovitis is prevalent in the older population, the aetiology remains unclear. Hyperuricemia, a modifiable metabolic disorder, may serve as an underlying mechanism of hand synovitis, but little is known about their relationship. We assessed the association between hyperuricemia and hand synovitis in a large population-based sample. METHODS: We performed a cross-sectional study in Longshan County, Hunan Province, China. Hyperuricemia was defined as a serum urate >420 μmol/L in men and >360 μmol/L in women...
April 3, 2024: Arthritis Care & Research
#25
JOURNAL ARTICLE
Vinila Baljepally, Mary E McBride, Lou Smith, J Bracken Burns
Idiopathic acute rectal necrosis (IARN) is a rare condition due to a robust rectal blood supply. This report describes an 83-year-old man presenting with septic shock due to distal sigmoid and complete rectal necrosis with perforation. He underwent emergent exploratory laparotomy, sigmoid and proximal rectum resection, and end sigmoid colostomy creation with delayed distal rectal evaluation. Bedside proctoscopy revealed pale, viable-appearing distal rectal mucosa on postoperative day 3. The patient had a protracted, complicated hospital stay but required no further operative intervention...
April 3, 2024: American Surgeon
#26
JOURNAL ARTICLE
Julius Mutoro, Justus Barageine Kafunjo, Freddy Eric-Kitutu, Joan Kalyango, Iving Mumbere, Nathan Nshakira
Malaria in pregnancy poses a high risk of poor maternal and neonatal outcomes and WHO recommends IPTp. However, its uptake has remained sub-optimal among mothers who attend antenatal care at private-not-for-profit health facilities. This study determined the level of and factors associated with uptake Intermittent preventive treatment of malaria for pregnant women (IPTp) at private-not-for-profit (PNFP) health facilities in Kasese District, Uganda. This was a cross-sectional study involving 396 postpartum mothers in the postnatal wards of 8 PNFP health facilities in Kasese district was conducted in September 2022...
2024: PLOS Glob Public Health
#27
JOURNAL ARTICLE
Hill L Wolfe, Amy Jeon, Joseph L Goulet, Tracy L Simpson, Jacob R Eleazer, Guneet K Jasuja, John R Blosnich, Michael R Kauth, Jillian C Shipherd, Alyson J Littman
OBJECTIVES: To examine the associations of two measures of minority stress, non-affirmation minority stress and internalized transphobia, with subjective cognitive decline (SCD) among transgender and gender diverse (TGD) veterans. METHOD: We administered a cross-sectional survey from September 2022 to July 2023 to TGD veterans. The final analytic sample included 3,152 TGD veterans aged ≥45 years. We used a generalized linear model with quasi-Poisson distribution to calculate prevalence ratios (PR) and 95% confidence intervals (CIs) measuring the relationship between non-affirmation minority stress and internalized transphobia and past-year SCD...
April 3, 2024: Aging & Mental Health
#28
JOURNAL ARTICLE
Faiqa Nazir, Iqra Munir, Gurkan Yesiloz
Proteins are promising substances for introducing new drug carriers with efficient blood circulation due to low possibilities of clearance by macrophages. However, such natural biopolymers have highly sophisticated molecular structures, preventing them from being assembled into nanoplatforms with manipulable payload release profiles. Here, we report a novel anticancer nanodrug carrier moonlighting protein, Aprotinin, to be used as a newly identified carrier for cytotoxic drugs. The Aprotinin-Doxorubicin (Apr-Dox) nanobioconjugate was prepared via a single-step microfluidics coflow mixing technique, a feasible and simple way to synthesize a carrier-based drug design with a double-barreled approach that can release and actuate two therapeutic agents simultaneously, i...
April 2, 2024: ACS Applied Materials & Interfaces
#29
JOURNAL ARTICLE
Rodrigo Camacho-Neciosup, Ericka N Balcazar-Huaman, Margarita L Alvarez-Vilchez, Janith P De la Cruz-Galán, Yubely Gálvez-Guadalupe, Edwin D Garcia-Muñoz, Greysi Cerron-Daga, Virgilio E Failoc-Rojas, Mario J Valladares-Garrido
INTRODUCTION: The pandemic of COVID-19 continues to impact people worldwide, with more than 755 million confirmed cases and more than 6.8 million reported deaths. Although two types of treatment, antiviral and immunomodulatory therapy, have been approved to date, vaccination has been the best method to control the spread of the disease. OBJECTIVE: To explore factors associated with the intention to be vaccinated with the COVID-19 booster dose in Peru. MATERIAL AND METHODS: Cross-sectional study, using virtual and physical surveys of adults with two or more doses of COVID-19 vaccine, where the dependent variable was the intention to be vaccinated (IBV) with the booster dose...
2024: PeerJ
#30
JOURNAL ARTICLE
Nivetha Vengadessin, Premkumar Ramasubramani, Ganesh Kumar Saya
OBJECTIVES: Medical profession, a competitive and ever-updating field which requires great commitment, imposes a stressful environment for students. Our study aimed to find the prevalence and factors associated with psychological illness. METHODS: A cross-sectional analytical study was done among medical students in Puducherry. A stratified random sampling strategy was incorporated to achieve a calculated sample size of 384. The presence of anxiety and depression, perceived stress and addiction to the phone were assessed using the Hospital Anxiety and Depression Scale, Perceived Stress Scale, and Smartphone Addiction Scale - short version...
April 2, 2024: International Journal of Adolescent Medicine and Health
#31
JOURNAL ARTICLE
Ramjas Prajapati, Vikas Ostwal, Sujay Srinivas, Reena Engineer, Prabhat Bhargava, Avanish Saklani, Ashwin D'Souza, Suman Kumar, Zoya Peelay, P Manali, Anant Ramaswamy
BACKGROUND: There is limited data with regard to the use of modified 5-fluoroural-leucovorin-irinotecan-oxaliplatin (mFOLFIRINOX) in terms of tolerance and enabling total mesorectal excision (TME) of locally advanced rectal adenocarcinomas (LARC) with high-risk characteristics (T4b status, signet ring histology etc) post standard neoadjuvant long course chemoradiation (NACTRT) or short course radiation (SCRT) and chemotherapy. MATERIALS AND METHODS: Patients with LARC from January 2018 to December 2020 receiving mFOLFIRINOX post NACTRT/SCRT to facilitate TME were evaluated...
January 1, 2024: Journal of Cancer Research and Therapeutics
#32
JOURNAL ARTICLE
Niyaz Shadmanov, Vusal Aliyev, Guglielmo Niccolò Piozzi, Barıs Bakır, Suha Goksel, Oktar Asoglu
Although there's growing information about the long-term oncological effects of robotic surgery for rectal cancer, the procedure is still relatively new. This study aimed to assess the long-term oncological results of total mesorectal excision (TME) performed laparoscopically versus robotically in the setting of rectal cancer. Restrospective analysis of a prospectively maintained database. A total of 489 laparoscopic (L-TME) and 183 robotic total mesorectal excisions (R-TME) were carried out by a single surgeon between 2013 and 2023...
March 30, 2024: Journal of Robotic Surgery
#33
REVIEW
Alice Blache, Florent Carsuzaa, Arnaud Beddok, Sophie Deneuve, Pierre-Yves Marcy, Dylan James, Catherine Dejean, Stéphanie Dapké, Bernard Devauchelle, Juliette Thariat
The management of head and neck cancers is multidisciplinary, often relying on the use of combined treatments to maximize the chances of cure. Combined treatments are however also responsible for cumulative side effects. The aim of reconstructive surgery with a flap is to restore a function lost with the loss of substance from the tumor resection. However, changes in reconstructive surgery have impact of postoperative radiotherapy planning. The optimization of imaging protocols for radiotherapy planning should make it possible to identify postoperative changes and to distinguish flaps from surrounding native tissues to delineate the flaps and document the spontaneous evolution of these flaps or dose-effect relationships in case of radiotherapy...
March 28, 2024: Bulletin du Cancer
#34
JOURNAL ARTICLE
R Mouriño-Ruiz, G Serral, X Continente, M J López, C Lapena, R Puigpinós-Riera
OBJECTIVES: Loneliness is a public health issue among older adults. We designed an intervention offering 10 sessions with diverse artistic methods (ArtGran). This study assessed the effectiveness of ArtGran in reducing loneliness and its negative effects on health in community-dwelling older adults in 2022 in Barcelona. STUDY DESIGN: Quasi-experimental study, with an intervention group (IG) and a comparison group (CG). METHODS: The sample included residents aged ≥70 years from 6 selected neighbourhoods of Barcelona...
March 28, 2024: Public Health
#35
JOURNAL ARTICLE
Jamee Guerra Valencia, Antonio Castillo-Paredes, Carolina Gibaja-Arce, Lorena Saavedra-Garcia, Noel C Barengo
BACKGROUND: Cardiovascular diseases (CVDs) are a global health threat, significantly impacting Latin America. Cardiometabolic abnormalities (CAs), encompassing lipid profile, fasting plasma glucose, and blood pressure, contribute to CVD prevalence. Despite high CA incidence, research in Latin America has primarily focused on traditional adiposity indices, overlooking the intricate relationship between fat and lean body components. The study aimed to analyze the association between the lean-to-fat mass ratio (LFMR) and CAs in the adult Peruvian population...
March 2024: Journal of Clinical Medicine Research
#36
JOURNAL ARTICLE
Anne-Sophie Hardel, Hélène Flye Sainte Marie, Simon Lorrain, Silvia Iacobelli, Glorianne Lazaro, Malik Boukerrou, Phuong Lien Tran
OBJECTIVE: To compare clinical pregnancy rates following intrauterine insemination performed after hysterosalpingography (HSG) or hysterosalpingo-foam-sonography (HyFoSy). MATERIAL AND METHODS: This is a retrospective study including 242 intrauterine insemination (IUI) performed between 2015 and 2020 at the fertility center of the Reunion Island. Among these inseminations, 121 with previous HSG and 121 with previous HyFoSy were matched. The main outcome of interest was clinical pregnancy rate...
March 26, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
#37
JOURNAL ARTICLE
Shanze Sadiq, Karen E S Hamre, Samhita Kumar, Sarah Bazur-Leidy, Luccène Désir, M Martha Désir, Murielle C Gilbert, V Madsen Beau de Rochars, Marc-Aurèle Telfort, Gregory S Noland, Eve Byrd
BACKGROUND: Neglected tropical diseases (NTDs) inflict significant comorbid disability on the most vulnerable communities; yet interventions targeting the mental health of affected communities are lacking. A pilot study to assess the effectiveness of a chronic disease self-management program (CDSMP) was introduced to lymphatic filariasis peer support groups in Léogâne, Haiti. METHODS: Using a closed-cohort stepped-wedge cluster trial design, Hope Clubs were assigned into Arm 1 (n=118 members) and Arm 2 (n=92)...
March 28, 2024: International Health
#38
JOURNAL ARTICLE
Zhe Ma, Lin Peng, Yaoyao Sheng, Wenhui Chu, Yongqian Fu
Angelicae pubescentis radix (APR) has been traditionally used for thousands of years in China to treat rheumatoid arthritis (RA), an autoimmune disorder. As the main active coumarin of APR, columbianadin (CBN) exhibits a significant anti-inflammatory effect in vitro. However, the anti-inflammatory activity and underlying mechanism of CBN in vivo remain unclear. This work aimed to elucidate the anti-inflammatory activity of CBN in vivo and its related signaling pathways in a D-Gal-induced liver injury mouse model...
March 15, 2024: Pharmaceuticals
#39
JOURNAL ARTICLE
Ji Ann Cho, Soyeon Kim, Haein Shin, Hyunkyu Kim, Eun-Cheol Park
BACKGROUND: As excessive caffeine intake may be associated with anxiety disorders, one of the most prevalent mental illnesses among adolescents globally, this study investigated the association between high caffeine consumption and anxiety in a nationally representative sample of South Korean adolescents. METHODS: 46,873 participants from the Korea Youth Risk Behavior Web-based Survey (KYRBS) 2022 were included. The Generalized Anxiety Disorder-7 (GAD-7) questionnaire was used to evaluate anxiety symptoms...
March 11, 2024: Nutrients
#40
JOURNAL ARTICLE
Moses Ocan, Winnie Nambatya, Caroline Otike, Loyce Nakalembe, Sam Nsobya
BACKGROUND: Malaria remains one of the leading causes of morbidity, and mortality in Uganda. A large proportion of malaria symptomatic patients seek healthcare in private sector. However, availability and affordability are major barriers to access to effective treatment. The private sector copayment mechanism in Uganda aims to increase availability and affordability of antimalarial agents. Our study assessed availability, price, and market share of quality assured artemisinin-based combination therapies (QAACTs) in private drug outlets in selected districts during the implementation of copayment mechanism...
2024: PloS One
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