keyword
MENU ▼
Read by QxMD icon Read
search

APR

keyword
https://www.readbyqxmd.com/read/28806149/detection-of-nanophyetus-salmincola-in-water-snails-and-fish-tissues-by-quantitative-pcr
#1
Maureen K Purcell, Rachel L Powers, Bonnie L Besijn, Paul K Hershberger
We report the development and validation of two quantitative polymerase chain reaction (qPCR) assays to detect N. salmincola DNA in water samples and fish and snail tissues. Analytical and diagnostic validation demonstrated good sensitivity, specificity and repeatability of both qPCR assays. N. salmincola DNA copy number in kidney tissue was significantly correlated with metacercariae counts based on microscopy. Extraction methods were optimized for the sensitive qPCR detection of N. salmincola DNA in settled water samples...
August 14, 2017: Journal of Aquatic Animal Health
https://www.readbyqxmd.com/read/28802807/acute-phase-response-in-babesia-canis-and-dirofilaria-immitis-co-infections-in-dogs
#2
Zorana Milanović, Anja Ilić, Jelena Francuski Andrić, Vladimir Radonjić, Anđelo Beletić, Milica Kovačević Filipović
Babesia canis and Dirofilaria immitis are emerging and geographically overlapping vector-borne pathogens in dogs. Infection with B. canis leads to acute-phase response (APR) that can be mild to severe and results in either non-complicated or complicated forms of the disease. The aim of this study was to determine whether acute B. canis infection is more severe in dogs with underlying asymptomatic D. immitis infection. Dogs of both sexes, different ages and breeds, with naturally occurring mono-infections with B...
August 2, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28802179/prevalence-of-population-smoking-cessation-by-electronic-cigarette-use-status-in-a-national-sample-of-recent-smokers
#3
Daniel P Giovenco, Cristine D Delnevo
INTRODUCTION: Amid decreasing rates of cigarette smoking and a rise in e-cigarette use, there is a need to understand population patterns of use to inform tobacco control efforts and evaluate whether e-cigarettes may play a role in tobacco harm reduction. METHODS: This study merged data from the 2014 and 2015 National Health Interview Survey (NHIS) and restricted the sample to recent smokers [i.e., current smokers and former smokers who quit in 2010 or later (n=15,532)]...
August 3, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28798752/qtl-analysis-and-nested-association-mapping-for-adult-plant-resistance-to-powdery-mildew-in-two-bread-wheat-populations
#4
Yan Ren, Weixiu Hou, Caixia Lan, Bhoja R Basnet, Ravi P Singh, Wei Zhu, Xiyong Cheng, Dangqun Cui, Feng Chen
CIMMYT wheat (Triticum aestivum L.) lines Francolin#1 and Quaiu#3 displayed effective and stable adult plant resistance (APR) to Chinese Blumeria graminis f. sp. tritici isolates in the field. To elucidate their genetic basis of resistance, two recombinant inbred line (RIL) populations of their crosses with Avocet, the susceptible parent, were phenotyped in Zhengzhou and Shangqiu in the 2014-2015 and 2015-2016 cropping seasons. These populations were also genotyped with SSR (simple sequence repeat markers) and DArT (diversity arrays technology) markers...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28797469/multivariate-statistical-process-control-in-product-quality-review-assessment%C3%A2-%C3%A2-a-case-study
#5
M Kharbach, Y Cherrah, Y Vander Heyden, A Bouklouze
According to the Food and Drug Administration and the European Good Manufacturing Practices (GMP) guidelines, Annual Product Review (APR) is a mandatory requirement in GMP. It consists of evaluating a large collection of qualitative or quantitative data in order to verify the consistency of an existing process. According to the Code of Federal Regulation Part 11 (21 CFR 211.180), all finished products should be reviewed annually for the quality standards to determine the need of any change in specification or manufacturing of drug products...
August 7, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/28776194/a-cross-sectional-study-among-polish-hunters-seroprevalence-of-hepatitis-e-and-the-analysis-of-factors-contributing-to-hev-infections
#6
Anna Baumann-Popczyk, Bartłomiej Popczyk, Elżbieta Gołąb, Wioletta Rożej-Bielicka, Małgorzata Sadkowska-Todys
Hepatitis E virus (HEV) is known as zoonotic agent. The main reservoirs of HEV in Europe are pigs, wild boars, and deer. Hunting activity is considered to be a risk factor for HEV infection. We conducted a cross-sectional study among 1021 Polish hunters. To understand socio-demographic characteristics of this population and to gather information on potential exposures, all participants completed a questionnaire. Commercial immunoassays were employed to estimate seroprevalence anti-HEV. Samples with confirmed positive result of anti-HEV IgM were examined for HEV RNA...
August 3, 2017: Medical Microbiology and Immunology
https://www.readbyqxmd.com/read/28765126/cost-utility-and-budget-impact-analyses-of-the-use-of-nepa-for-chemotherapy-induced-nausea-and-vomiting-prophylaxis-in-italy
#7
Umberto Restelli, Gabriella Saibene, Patrizia Nardulli, Roberta Di Turi, Erminio Bonizzoni, Francesca Scolari, Tania Perrone, Davide Croce, Luigi Celio
OBJECTIVE: To evaluate the efficiency of resources allocation and sustainability of the use of netupitant+palonosetron (NEPA) for chemotherapy-induced nausea and vomiting (CINV) prophylaxis assuming the Italian National Health Service (NHS) perspective. A published Markov model was adapted to assess the incremental cost-utility ratio of NEPA compared with aprepitant (APR) + palonosetron (PALO), fosaprepitant (fAPR) + PALO, APR + ondansetron (ONDA), fAPR + ONDA in patients receiving a highly emetogenic chemotherapy (HEC) and with APR + PALO and fAPR + PALO in patients receiving a moderately emetogenic chemotherapy (MEC)...
August 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/28761483/road-killed-carnivores-illustrate-the-status-of-zoonotic-helminthes-in-caspian-sea-littoral-of-iran
#8
Aida Vafae Eslahi, Eshrat Beigom Kia, Iraj Mobedi, Meysam Sharifdini, Milad Badri, Gholamreza Mowlavi
BACKGROUND: Carnivore carcasses on the roads can be regarded as study materials in parasitology and eco-epidemiology. Stray carnivores such as dogs and cats are known to harbor so many different pathogens like zoonotic helminthes. The current investigation, apparent the status of the helminthic parasites found in road killed carnivores from different parts of Guilan Province north of Iran. METHODS: Fifty road killed carnivores including 27 stray dogs (Canis familiaris), 11 golden jackals (Canis aureus) and 12 stray cats (Felis catus) were collected from 21 locations of Guilan Province, during Apr to Nov 2015...
April 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28761462/subtypes-distribution-and-frequency-of-blastocystis-sp-isolated-from-diarrheic-and-non-diarrheic-patients
#9
Nahid Jalallou, Shahrokh Iravani, Mostafa Rezaeian, Atefe Alinaghizade, Hamed Mirjalali
BACKGROUND: Blastocystis is one of the most common parasites, reported from both human and animals. This parasite is more prevalent in regions with low levels of hygiene, close contact with animal and unsuitable disposal systems. The aim of the study was to subtype Blastocystis sp., isolated from diarrheic and non-diarrheic patients using sequencing of 18S ribosomal DNA. METHODS: Totally, 300 stool samples were collected from diarrheic and nondiarrheic patients referred to Imam Reza Hospital, Tehran from Apr to Aug 2015...
January 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28756138/mutant-p53-as-a-target-for-cancer-treatment
#10
REVIEW
Michael J Duffy, Naoise C Synnott, John Crown
TP53 (p53) is the single most frequently altered gene in human cancers, with mutations being present in approximately 50% of all invasive tumours. However, in some of the most difficult-to-treat cancers such as high-grade serous ovarian cancers, triple-negative breast cancers, oesophageal cancers, small-cell lung cancers and squamous cell lung cancers, p53 is mutated in at least 80% of samples. Clearly, therefore, mutant p53 protein is an important candidate target against which new anticancer treatments could be developed...
July 27, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28750614/determinants-of-overweight-with-concurrent-stunting-among-ghanaian-children
#11
Benedicta K Atsu, Chris Guure, Amos K Laar
BACKGROUND: Malnutrition (undernutrition and overnutrition) is a major public health problem in Ghana -affecting growth and development of individuals and the nation. Stunting and overweight are of particular interest, as recent national surveys show a rising trend of overnutrition and stubbornly high burden of stunting among Ghanaian children. There are currently no data on the simultaneous occurrence of overweight and stunting within individuals in Ghana. This paper presents the burden, the individual-level, and contextual determinants of overweight with concurrent stunting among Ghanaian children...
July 27, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28747169/optimising-decision-making-on-illness-absenteeism-due-to-fever-and-common-infections-within-childcare-centres-development-of-a-multicomponent-intervention-and-study-protocol-of-a-cluster-randomised-controlled-trial
#12
K K B Peetoom, R Crutzen, J M H A Bohnen, R Verhoeven, H J M G Nelissen-Vrancken, B Winkens, G J Dinant, J W L Cals
BACKGROUND: Evidence has shown that children 0-4 year-old attending childcare are prone to acquire infections compared to children cared for at home, with fever being the most common symptom. Illness absenteeism due to fever and common infections is substantial and mostly driven by unrealistic concerns and negative attitude towards fever of both childcare staff and parents, resulting in illness absenteeism from childcare, work absenteeism among parents and healthcare service use. The objective of this study is to optimise decision making among childcare staff on illness absenteeism due to fever and common infections in childcare...
July 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28743765/higher-degradation-of-l-cys-by-o-acetylserine-thiolyases-in-sarcocornia-than-salicornia
#13
Assylay Kurmanbayeva, Aizat Bekturova, Sudhakar Srivastava, Aigerim Soltabayeva, Mohammad Suhail Khan, Octavio Salazar, Nina V Fedoroff, Armine Asatryan, Yvonne Ventura, Moshe Sagi
Salicornia and Sarcocornia are almost identical halophytes whose edible succulent shoots hold promise for commercial production in saline water. Enhanced sulfur nutrition may be beneficial to crops naturally grown on high sulfate. However, little is known about sulfate nutrition in halophytes. Here we show that Salicornia europaea (ecotype RN) exhibits a significant increase in biomass and organic-S accumulation in response to supplemental sulfate, while Sarcocornia fruticosa (ecotype VM) does not, instead exhibiting increased sulfate accumulation...
July 25, 2017: Plant Physiology
https://www.readbyqxmd.com/read/28740955/outcomes-of-early-cholecystectomy-within-7-days-of-admission-for-acute-cholecystitis-according-to-diagnosis-and-severity-grading-by-tokyo-2013-guideline
#14
İsmail Sert, Fuat İpekci, Ömer Engin, Muharrem Karaoğlan, Özhan Çetindağ
OBJECTIVE: The timing of early cholecystectomy in acute cholecystitis is still controversial, and data regarding the use of Tokyo 2013 guideline for diagnosis and severity grading in Acute Cholecystitis is limited. The aim of this study was to evaluate the clinical and pathologic outcomes of early cholecystectomy after 72 hr and within seven days of index admission according to Tokyo 2013 guideline for diagnosis and severity grading of Acute cholecystitis (in patients with Acute cholecystitis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740921/long-term-outcomes-and-toxicities-of-a-large-cohort-of-anal-cancer-patients-treated-with-dose-painted-imrt-per-rtog-0529
#15
Devarati Mitra, Theodore S Hong, Nora Horick, Brent Rose, Lorraine N Drapek, Lawrence S Blaszkowsky, Jill N Allen, Eunice L Kwak, Janet E Murphy, Jeffrey W Clark, David P Ryan, James C Cusack, Liliana G Bordeianou, David L Berger, Jennifer Y Wo
PURPOSE: To describe the outcomes and toxicities of the largest cohort to date of patients with anal squamous cell carcinoma uniformly treated with concurrent chemoradiation using dose-painted intensity modulated radiation therapy (DP-IMRT) according to RTOG 0529. METHODS AND MATERIALS: We identified 99 eligible patients with anal cancer who were treated at our institution with definitive chemoradiation using DP-IMRT between 2005 and 2015 per RTOG 0529 dosing guidelines...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28738256/p53-and-mitf-bcl-2-identified-as-key-pathways-in-the-acquired-resistance-of-nras-mutant-melanoma-to-mek-inhibition
#16
Ahmad Najem, Mohammad Krayem, François Salès, Nader Hussein, Bassam Badran, Caroline Robert, Ahmad Awada, Fabrice Journe, Ghanem E Ghanem
Activating mutations in Neuroblastoma RAS viral oncogene homolog (NRAS) are found in 15-30% of melanomas and are associated with a poor prognosis. Although MAP kinase kinase (MEK) inhibitors used as single agents showed a limited clinical benefit in patients with NRAS-mutant melanoma due to their rather cytostatic effect and high toxicity, their combination with other inhibitors of pathways known to cooperate with MEK inhibition may maximise their antitumour activity. Similarly, in a context where p53 is largely inactivated in melanoma, hyperexpression of Microphthalmia associated transcription factor (MITF) and its downstream anti-apoptotic targets may be the cause of the restraint cytotoxic effects of MEK inhibitors...
July 21, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28735402/determination-of-total-sulfur-sulfate-sulfite-thiosulfate-and-sulfolipids-in-plants
#17
Assylay Kurmanbayeva, Galina Brychkova, Aizat Bekturova, Inna Khozin, Dominic Standing, Dmitry Yarmolinsky, Moshe Sagi
In response to oxidative stress the biosynthesis of the ROS scavenger, glutathione is induced. This requires the induction of the sulfate reduction pathway for an adequate supply of cysteine, the precursor for glutathione. Cysteine also acts as the sulfur donor for the sulfuration of the molybdenum cofactor, crucial for the last step of ABA biosynthesis. Sulfate and sulfite are, respectively, the precursor and intermediate for cysteine biosynthesis and there is evidence for stress-induced sulfate uptake and further downstream, enhanced sulfite generation by 5'-phosphosulfate (APS) reductase (APR, EC 1...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28735401/determination-of-enzymes-associated-with-sulfite-toxicity-in-plants-kinetic-assays-for-so-apr-sir-and-in-gel-sir-activity
#18
Galina Brychkova, Assylay Kurmanbayeva, Aizat Bekturova, Inna Khozin, Dominic Standing, Dmitry Yarmolinsky, Moshe Sagi
The amino acid cysteine plays a major role in plant response to abiotic stress by being the donor of elemental sulfur for the sulfuration of the molybdenum cofactor, otherwise the last step of ABA biosynthesis, the oxidation of abscisic aldehyde, is inactivated. Additionally, cysteine serves as a precursor for the biosynthesis of glutathione, the reactive oxygen species scavenger essential for redox status homeostasis during stress. Cysteine is generated by the sulfate reductive pathway where sulfite oxidase (SO; EC 1...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28728243/-the-treatment-effect-of-eustachian-tube-atresia-with-laser-and-connical-plastic-tube-after-radiotherapy-for-nasopharyngeal-carcinoma
#19
H G Gao, J Tong, W W Chen
Objective: To investigate the method in treatment of Eustschian tube atresia caused by radiotherapy. Methods: Two cases diagnosed of Eustschian tube atresia following radiotherapy were retrospectively analyzed in Department of Otorhinolaryngology, Divided Hospital of Shanghai University Communication Affiliated First People Hospital in Apr. 2014 and Oct. 2015. Both cases were female, 65 and 64 years old, and accepted radiotherapy six and 20 years ago respectively. The pharyngeal orifices of Eustschian tube were found to be totally closed under endoscope...
July 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28724084/comparison-of-models-and-whole-genome-profiling-approaches-for-genomic-enabled-prediction-of-septoria-tritici-blotch-stagonospora-nodorum-blotch-and-tan-spot-resistance-in-wheat
#20
Philomin Juliana, Ravi P Singh, Pawan K Singh, Jose Crossa, Jessica E Rutkoski, Jesse A Poland, Gary C Bergstrom, Mark E Sorrells
The leaf spotting diseases in wheat that include Septoria tritici blotch (STB) caused by , Stagonospora nodorum blotch (SNB) caused by , and tan spot (TS) caused by pose challenges to breeding programs in selecting for resistance. A promising approach that could enable selection prior to phenotyping is genomic selection that uses genome-wide markers to estimate breeding values (BVs) for quantitative traits. To evaluate this approach for seedling and/or adult plant resistance (APR) to STB, SNB, and TS, we compared the predictive ability of least-squares (LS) approach with genomic-enabled prediction models including genomic best linear unbiased predictor (GBLUP), Bayesian ridge regression (BRR), Bayes A (BA), Bayes B (BB), Bayes Cπ (BC), Bayesian least absolute shrinkage and selection operator (BL), and reproducing kernel Hilbert spaces markers (RKHS-M), a pedigree-based model (RKHS-P) and RKHS markers and pedigree (RKHS-MP)...
July 2017: Plant Genome
keyword
keyword
118103
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"