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https://www.readbyqxmd.com/read/29348462/piperlongumine-and-p53-reactivator-apr-246-selectively-induce-cell-death-in-hnscc-by-targeting-gstp1
#1
Wei Hang, Zhi-Xian Yin, Gang Liu, Qinghua Zeng, Xiang-Feng Shen, Qian-Hui Sun, Dong-Dong Li, Yong-Ping Jian, Yang-He Zhang, Yi-Shu Wang, Cheng-Shi Quan, Rui-Xun Zhao, Yu-Lin Li, Zhi-Xiang Xu
TP53 mutations frequently occur in head and neck squamous cell carcinoma (HNSCC) patients without human papillomavirus infection. The recurrence rate for these patients is distinctly high. It has been actively explored to identify agents that target TP53 mutations and restore wild-type (WT) TP53 activities in HNSCC. PRIMA-1 (p53-reactivation and induction of massive apoptosis-1) and its methylated analogue PRIMA-1Met (also called APR-246) were found to be able to reestablish the DNA-binding activity of p53 mutants and reinstate the functions of WT p53...
January 18, 2018: Oncogene
https://www.readbyqxmd.com/read/29348204/tumor-suppressor-apc-is-an-attenuator-of-spindle-pulling-forces-during-c-elegans-asymmetric-cell-division
#2
Kenji Sugioka, Lars-Eric Fielmich, Kota Mizumoto, Bruce Bowerman, Sander van den Heuvel, Akatsuki Kimura, Hitoshi Sawa
The adenomatous polyposis coli (APC) tumor suppressor has dual functions in Wnt/β-catenin signaling and accurate chromosome segregation and is frequently mutated in colorectal cancers. Although APC contributes to proper cell division, the underlying mechanisms remain poorly understood. Here we show that Caenorhabditis elegans APR-1/APC is an attenuator of the pulling forces acting on the mitotic spindle. During asymmetric cell division of the C. elegans zygote, a LIN-5/NuMA protein complex localizes dynein to the cell cortex to generate pulling forces on astral microtubules that position the mitotic spindle...
January 18, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29343315/subclinical-inflammation-affects-iron-and-vitamin-a-but-not-zinc-status-assessment-in-senegalese-children-and-cambodian-children-and-women
#3
Marion Fiorentino, Marlène Perignon, Khov Kuong, Chhoun Chamnan, Jacques Berger, Frank T Wieringa
OBJECTIVE: To assess the impact of the acute-phase response (APR) during inflammation on Fe, Zn and vitamin A biomarkers to allow accurate evaluation of micronutrient status in populations. DESIGN: Ferritin (FER), soluble transferrin receptor (TfR), retinol-binding protein (RBP), Zn, α1-acid glycoprotein and C-reactive protein concentrations were measured. Correction factors (CF) for each biomarker were calculated as the ratio for groups at different stages of inflammation v...
January 18, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29339997/the-relative-age-effect-on-soccer-players-in-formative-stages-with-different-sport-expertise-levels
#4
Alba Práxedes, Alberto Moreno, Luis García-González, David Pizarro, Fernando Del Villar
The Relative Age Effect (RAE) in sport has been targeted by many research studies. The objective of this study was to analyze, in amateur clubs, the RAE of soccer players, according to the sport expertise level of the team (e.g., A, B, C and subsequent) that they belong to within the same game category. 1,098 soccer players in formative stages took part in the study, with ages varying between 6 and 18 years old (U8 to U19 categories). All of them were members of 4 Spanish federated clubs. The birth dates were classified into 4 quartiles (Q1 = Jan-Mar; Q2 = Apr-Jun; Q3 = Jul-Sept; Q4 = Oct-Dec)according to the team they belonged to...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339177/trends-in-reporting-histological-subtyping-of-renal-cell-carcinoma-association-with-cancer-center-type
#5
Ted Gansler, Stacey Fedewa, Mahul B Amin, Chun Chieh Lin, Ahmedin Jemal
Histological classification of renal cell carcinoma (RCC) has become increasingly important for clinical management. We identified 295,483 RCC diagnosed from 1998-2014 in the National Cancer Database (NCDB) to examine temporal trends in proportions of RCC with unspecified histology and several specific histologies from the 1998 and 2004 World Health Organization classifications of RCC. Further, multivariable log binomial analysis of 101,062 RCC diagnosed from 2010-2014 was used to determine whether the association of diagnosing/treating facility type and the proportion of unspecified RCC is independent of patient demographic and clinical factors...
January 12, 2018: Human Pathology
https://www.readbyqxmd.com/read/29336226/identifying-metrics-before-and-after-readmission-following-head-and-neck-surgery-and-factors-affecting-readmission-rate
#6
Sidharth V Puram, Neil Bhattacharyya
Objectives Determine nationally representative readmission rates after head and neck cancer (HNCA) surgery and factors associated with readmission. Study Design Cross-sectional analysis of admissions database. Methods The 2013 Nationwide Readmissions Database was analyzed for HNCA surgery admissions and subsequent readmission within 30 days. The readmission rate, length of stay (LOS), disposition, mortality rate, and total charges were determined. Diagnoses and procedures upon readmission were quantified. Factors that were associated with readmission were determined...
January 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29334872/labelling-as-reference-centre-of-grace-groupe-francophone-de-r%C3%A3-habilitation-am%C3%A3-lior%C3%A3-e-apr%C3%A3-s-chirurgie-for-colorectal-surgery-its-impact-on-the-implementation-of-enhanced-recovery-programme-at-the-university-hospital-of-li%C3%A3-ge
#7
Coralie Daenen, Carla Coimbra, Grégory Hans, Jean Joris
BACKGROUND: Enhanced recovery programme (ERP) has been used in our hospital since 2005 for selected colorectal surgeries. Since October 2015, after labelling as GRACE reference centre, we included all patients scheduled for elective colorectal surgery in this programme. We assessed the impact of our labelling on the implementation of ERP. METHODS: Results of our first 100 patients entered in the GRACE database were analyzed: length of stay, complications, readmission, adherence to the protocol...
January 15, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29331548/effect-of-outpatient-antibiotics-for-urinary-tract-infections-on-antimicrobial-resistance-among-commensal-enterobacteriaceae-a-multinational-prospective-cohort-study
#8
Andrew J Stewardson, Jascha Vervoort, Niels Adriaenssens, Samuel Coenen, Maciek Godycki-Cwirko, Anna Kowalczyk, Benedikt Huttner, Christine Lammens, Surbhi Malhotra-Kumar, Herman Goossens, Stephan Harbarth
OBJECTIVES: We quantified the impact of antibiotics prescribed in primary care for urinary tract infections (UTIs) on intestinal colonisation by ciprofloxacin-resistant (CIP-RE) and extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE), while accounting for household clustering. METHODS: Prospective cohort study from January 2011 to August 2013 at primary care sites in Belgium, Poland and Switzerland. We recruited outpatients requiring antibiotics for suspected UTIs or asymptomatic bacteriuria (exposed patients), outpatients not requiring antibiotics (non-exposed patients), and 1-3 household contacts for each patient...
January 10, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29325814/corrigendum-to-development-of-hypomelanotic-macules-is-associated-with-constitutive-activated-mtorc1-in-tuberous-sclerosis-complex-mol-genet-metab-120-4-apr-2017-384-391
#9
L B Møller, B Schönewolf-Greulich, T Rosengren, L J Larsen, J R Ostergaard, M Sommerlund, C Ostenfeldt, B Stausbøl-Grøn, K M Linnet, P A Gregersen, U B Jensen
No abstract text is available yet for this article.
January 8, 2018: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29322057/epidemiological-study-on-cutaneous-leishmaniasis-in-an-endemic-area-of-qom-province-central-iran
#10
Abedin Saghafipour, Hassan Vatandoost, Ali Reza Zahraei-Ramazani, Mohammad Reza Yaghoobi-Ershadi, Moharram Karami Jooshin, Yavar Rassi, Mohammad Reza Shirzadi, Amir Ahmad Akhavan, Ahmad Ali Hanafi-Bojd
Background: Cutaneous leishmaniasis (CL) is one of the most important health problems in many areas of Iran. There are two forms of the disease in Iran, anthroponotic and zoonotic CL. This study conducted to assess the epidemiological situation of CL in an endemic area of Qom Province, central Iran from Apr to Nov 2015. Methods: The sticky paper traps and aspirating tubes were used for collecting adult sand flies. Sherman traps and small insect nets were used to capture rodents and small mammals...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29322056/field-evaluation-of-outdoor-ultra-low-volume-ulv-applications-against-phlebotomine-sand-flies-diptera-psychodidae-in-al-rabta-north-west-of-libya
#11
Mostafa Ramahdan Dokhan, Mohamed Amin Kenawy, Taher Shaibi, Badereddin Bashir Annajar
Background: Al Rabta is a rural area in the North-West of Libya that represents an important focus of zoonotic cutaneous leishmaniasis. This study aimed to evaluate the effect of Ultra Low Volume (ULV) applications in controlling sand flies and its impact on leishmaniasis transmission in this area. Methods: Two neighboring villages were selected: Al Rabta West (RW) as cypermethrin treated village and Al Rabta East (RE) as check one. The ULV was evaluated through 3 spraying cycles during Apr, Jun and Sep 2013...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29319394/achieving-appropriate-gestational-weight-gain-the-role-of-healthcare-provider-advice
#12
Nicholas P Deputy, Andrea J Sharma, Shin Y Kim, Christine K Olson
BACKGROUND: The Institute of Medicine (IOM) revised gestational weight gain recommendations in 2009. We examined associations between healthcare provider advice about gestational weight gain and inadequate or excessive weight gain, stratified by prepregnancy body mass index category. MATERIALS AND METHODS: We analyzed cross-sectional data from women delivering full-term (37-42 weeks of gestation), singleton infants from four states that participated in the 2010-2011 Pregnancy Risk Assessment Monitoring System (unweighted n = 7125)...
January 10, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29318120/beyond-morality-assessment-of-the-capacity-of-faith-based-organizations-fbos-in-responding-to-the-hiv-aids-challenge-in-southeastern-nigeria
#13
Eze Edlyne Anugwom, Kenechukwu Anugwom
Background: For the world can get rid of the HIV/AIDS pandemic by 2030, there is need for more to be done especially in the case of countries in Africa. In Nigeria, such efforts have included Faith-Based Organizations (FBOs) recognized as partners in the National Response Framework. However, the extent to which these FBOs contribute to efforts to control the pandemic will depend on their capacity. Therefore, this study aimed to ascertain the technical and managerial capacity of these FBOs to respond to the pandemic in Nigeria...
January 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29313193/the-relationship-between-risk-perception-and-frequency-of-hiv-testing-among-men-who-have-sex-with-men-and-transgender-women-lima-peru
#14
S K Vargas, K A Konda, S R Leon, B Brown, J D Klausner, C Lindan, C F Caceres
HIV infections in Peru are concentrated among men who have sex with men (MSM) and transgender women (TW). HIV testing rates among them remain low, delaying entrance into care. We assessed the prevalence of frequent HIV testing (at least every 6 months) and associated factors among 310 MSM and TW who attend sexual health clinics in Lima, Peru, and who reported that they were HIV seronegative or unaware of their status. Only 39% of participants tested frequently, and 22% had never tested; 29% reported that they were at low or no risk for acquiring HIV...
January 8, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29304439/cryptosporidium-outbreak-in-calves-on-a-large-dairy-farm-effect-of-treatment-and-the-association-with-the-inflammatory-response-and-short-term-weight-gain
#15
Tarmo Niine, Elisabeth Dorbek-Kolin, Brian Lassen, Toomas Orro
Cryptosporidium spp. infections in neonatal dairy calves can cause diarrhoea and, in rare cases, death. The infection is usually self-limiting, but halofuginone lactate (HL) can be used prophylactically. Calves (n=144) in the study were born during a 2-month period on one farm. A total of 901 serum and 767 faecal samples were collected. Based on HL treatment, the calves were divided into 3 groups: I) not treated, II) treated incorrectly (treatment started >48h after birth, or lasted <7days), and III) treated correctly (started <48h after birth, and lasted ≥7days)...
December 27, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/29301254/favourable-perceptions-of-electronic-cigarettes-relative-to-cigarettes-and-the-associations-with-susceptibility-to-electronic-cigarette-use-in-hong-kong-chinese-adolescents
#16
Lok Tung Leung, Sai Yin Ho, Jianjiu Chen, Man Ping Wang, Tai Hing Lam
We investigated favourable perceptions of electronic cigarettes (ECs) relative to cigarettes and their associations with EC use susceptibility in adolescents. Hong Kong Chinese Secondary 1-6 (U.S. grade 7-12) students (n = 40,202) were surveyed in 2014/2015 on EC use, cigarette smoking, favourable perceptions of ECs relative to cigarettes, EC use susceptibility, family smoking, and socio-demographic characteristics. Cox regression yielded adjusted prevalence ratios (APRs) of EC use susceptibility in never users, excluding those unaware of ECs...
January 1, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29294977/risk-and-protective-factors-for-difficulty-controlling-violent-behavior-in-national-guard-and-reserve-service-members
#17
Miranda Worthen, Sujit D Rathod, Gregory Cohen, Laura Sampson, Robert Ursano, Robert Gifford, Carol Fullerton, Sandro Galea, Jennifer Ahern
Violent behavior is an important problem for military service members and veterans. A representative cohort of U.S. Reserve and National Guard personnel ( N = 1,293) were interviewed to assess self-reported problems controlling violent behavior, deployment traumas, posttraumatic stress disorder (PTSD), alcohol abuse, and social support. Poisson regression models were used to estimate the associations of violent behavior with risk and protective factors. Problems controlling violent behavior were uncommon among male (3...
November 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29288177/why-don-t-key-populations-access-hiv-testing-and-counselling-centres-in-nepal-findings-based-on-national-surveillance-survey
#18
Rachana Shrestha, Sairu Philip, Hemant Deepak Shewade, Bir Rawal, Keshab Deuba
OBJECTIVES: To assess the demographic, behavioural, psychosocial and structural factors associated with non-utilisation of HIV testing and counselling (HTC) services by female sex workers (FSWs) and men who have sex with men/transgender (MSM/TG). METHODS: This study involved a cross-sectional design. We used the national surveillance survey data of 2012, which included 610 FSWs and 400 MSM/TG recruited randomly from 22 and three districts of Nepal, respectively...
December 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29279806/incisional-negative-pressure-wound-therapy-for-perineal-wounds-after-abdominoperineal-resection-for-rectal-cancer-a-pilot-study
#19
Maxime J M van der Valk, Eelco J R de Graaf, Pascal G Doornebosch, Maarten Vermaas
Objective: Abdominoperineal resection (APR) is associated with high incidence of surgical wound infections. The use of incisional negative-pressure wound therapy (iNPWT) is known to reduce wound infections for several surgical indications. The aim of this pilot study was to investigate the potential of a new portable negative-pressure therapy device on perineal wound healing in patients undergoing APR. Approach: A new single-use incisional negative-pressure therapy device was applied in 10 patients. A negative pressure of -80 mmHg was continued for 7 days postsurgery...
December 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/29279235/attitudes-toward-working-conditions-are-european-union-workers-satisfied-with-their-working-hours-and-work-life-balance
#20
Nuria Matilla-Santander, Cristina Lidón-Moyano, Adrián González-Marrón, Kailey Bunch, Juan Carlos Martín-Sánchez, José M Martínez-Sánchez
OBJECTIVE: To describe the satisfaction with working hours and satisfaction with work-life balance and their association in the European Union (EU-28). METHOD: This is a cross-sectional study based on data from the Flash Eurobarometer 398 among workers of the EU-28 from 2014 (n=13,683). We calculated percentages and their 95% confidence intervals (95%CI). We also applied a multi-level generalised linear model using the Poisson family, to calculate the adjusted prevalence ratios (aPR) of satisfaction with work-life balance based on working hours...
December 23, 2017: Gaceta Sanitaria
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