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https://www.readbyqxmd.com/read/28229321/cerebral-endothelial-dysfunction-in-reversible-cerebral-vasoconstriction-syndrome-a-case-control-study
#1
Hyun Ah Choi, Mi Ji Lee, Chin-Sang Chung
BACKGROUND: The aim of this study is to investigate cerebral endothelial dysfunction in patients with reversible cerebral vasoconstriction syndrome (RCVS). METHODS: We prospectively recruited patients with RCVS, age-matched controls with episodic migraine, and age-matched healthy controls at Samsung Medical Center from Apr 2015 to Jul 2016. All participants underwent transcranial Doppler evaluation, with a breath-holding maneuver, for the evaluation of bilateral middle cerebral arteries (MCAs), posterior cerebral arteries (PCAs), and the basilar artery (BA)...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28227168/a-novel-method-for-splice-sites-prediction-using-sequence-component-and-hidden-markov-model
#2
Elham Pashaei, Alper Yilmaz, Mustafa Ozen, Nizamettin Aydin, Elham Pashaei, Alper Yilmaz, Mustafa Ozen, Nizamettin Aydin, Nizamettin Aydin, Alper Yilmaz, Elham Pashaei, Mustafa Ozen
With increasing growth of DNA sequence data, it has become an urgent demand to develop new methods to accurately predict the genes. The performance of gene detection methods mainly depend on the efficiency of splice site prediction methods. In this paper, a novel method for detecting splice sites is proposed by using a new effective DNA encoding method and AdaBoost.M1 classifier. Our proposed DNA encoding method is based on multi-scale component (MSC) and first order Markov model (MM1). It has been applied to the HS3D dataset with repeated 10 fold cross validation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222799/assessment-of-plasma-chitotriosidase-activity-ccl18-parc-concentration-and-np-c-suspicion-index-in-the-diagnosis-of-niemann-pick-disease-type-c-a-prospective-observational-study
#3
Isabel De Castro-Orós, Pilar Irún, Jorge Javier Cebolla, Victor Rodriguez-Sureda, Miguel Mallén, María Jesús Pueyo, Pilar Mozas, Carmen Dominguez, Miguel Pocoví
BACKGROUND: Niemann-Pick disease type C (NP-C) is a rare, autosomal recessive neurodegenerative disease caused by mutations in either the NPC1 or NPC2 genes. The diagnosis of NP-C remains challenging due to the non-specific, heterogeneous nature of signs/symptoms. This study assessed the utility of plasma chitotriosidase (ChT) and Chemokine (C-C motif) ligand 18 (CCL18)/pulmonary and activation-regulated chemokine (PARC) in conjunction with the NP-C suspicion index (NP-C SI) for guiding confirmatory laboratory testing in patients with suspected NP-C...
February 21, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28220677/toward-a-sociology-of-oceans
#4
John Hannigan
Despite covering around 70 percent of the earth's surface, the ocean has long been ignored by sociology or treated as merely an extension of land-based systems. Increasingly, however, oceans are assuming a higher profile, emerging both as a new resource frontier, a medium for geopolitical rivalry and conflict, and a unique and threatened ecological hot spot. In this article, I propose a new sociological specialty area, the "sociology of oceans" to be situated at the interface between environmental sociology and traditional maritime studies...
February 2017: Canadian Review of Sociology, Revue Canadienne de Sociologie
https://www.readbyqxmd.com/read/28219382/high-level-extracellular-protein-production-in-bacillus-subtilis-using-an-optimized-dual-promoter-expression-system
#5
Kang Zhang, Lingqia Su, Xuguo Duan, Lina Liu, Jing Wu
BACKGROUND: We recently constructed a Bacillus subtilis strain (CCTCC M 2016536) from which we had deleted the srfC, spoIIAC, nprE, aprE and amyE genes. This strain is capable of robust recombinant protein production and amenable to high-cell-density fermentation. Because the promoter is among the factors that influence the production of target proteins, optimization of the initial promoter, PamyQ from Bacillus amyloliquefaciens, should improve protein expression using this strain. This study was undertaken to develop a new, high-level expression system in B...
February 20, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28217301/risk-factors-for-perineal-wound-infection-after-abdominoperineal-resection-of-advanced-lower-rectal-cancer
#6
Takatoshi Nakamura, Takeo Sato, Kazushige Hayakawa, Yoko Takayama, Masanori Naito, Takahiro Yamanashi, Atsuko Tsutsui, Hirohisa Miura, Masahiko Watanabe
PURPOSE: Abdominoperineal resection (APR) of advanced lower rectal cancer carries a high incidence of perineal wound infection. The aim of this study was to retrospectively evaluate risk factors for perineal wound infection after APR. METHODS: The study group comprised 154 patients who underwent APR for advanced lower rectal cancer in our department from January 1990 through December 2012. The following 15 variables were studied as potential risk factors for perineal wound infection: sex, age, body-mass index, American Society of Anesthesiologists score, diabetes mellitus, preoperative albumin level, preoperative hemoglobin level, neoadjuvant chemoradiotherapy(NCRT), surgical procedure (open surgery vs...
March 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28202413/engineered-antibody-ch2-domains-binding-to-nucleolin-isolation-characterization-and-improvement-of-aggregation
#7
De-Zhi Li, Rui Gong, Jun Zheng, Xi-Hai Chen, Dimiter S Dimitrov, Qi Zhao
Smaller recombinant antibody fragments are now emerging as alternatives of conventional antibodies. Especially, immunoglobulin (Ig) constant CH2 domain and engineered CH2 with improved stability are promising as scaffolds for selection of specific binders to various antigens. We constructed a yeast display library based on an engineered human IgG1 CH2 scaffold with diversified loop regions. A group of CH2 binders were isolated from this yeast display library by panning against nucleolin, which is a tumor-associated antigen involved in cell proliferation, tumor cell growth and angiogenesis...
February 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28197530/mutant-p53-nrf2-axis-regulates-the-proteasome-machinery-in-cancer
#8
Kamil Lisek, Dawid Walerych, Giannino Del Sal
The proteasome machinery is a common target of gain-of-function p53 missense mutants. Upregulation of the proteasome fosters chemoresistance to proteasome inhibitors. In triple negative breast cancer cells this resistance mechanism, namely the Nrf2-regulated "bounce-back" response to proteasome inhibitors, can be overcome by targeting p53 mutant proteins with APR-246/PRIMA-1Met.
2017: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/28197206/survival-after-abdominoperineal-and-sphincter-preserving-resection-in-nonmetastatic-rectal-cancer-a-population-based-time-trend-and-propensity-score-matched-seer-analysis
#9
Rene Warschkow, Sabrina M Ebinger, Walter Brunner, Bruno M Schmied, Lukas Marti
Background. Abdominoperineal resection (APR) has been associated with impaired survival in nonmetastatic rectal cancer patients. It is unclear whether this adverse outcome is due to the surgical procedure itself or is a consequence of tumor-related characteristics. Study Design. Patients were identified from the Surveillance, Epidemiology, and End Results database. The impact of APR compared to coloanal anastomosis (CAA) on survival was assessed by Cox regression and propensity-score matching. Results. In 36,488 patients with rectal cancer resection, the APR rate declined from 31...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28182452/correction-to-kinnunen-et-al-2016
#10
(no author information available yet)
Reports an error in "Linking Boundary Crossing from Work to Nonwork to Work-Related Rumination across Time: A Variable- and Person-Oriented Approach" by Ulla Kinnunen, Taru Feldt, Jessica de Bloom, Marjaana Sianoja, Kalevi Korpela and Sabine Geurts (Journal of Occupational Health Psychology, Advanced Online Publication, Apr 28, 2016, np). In the original article, there were errors in "The Present Study" section and in the "Identifying Subgroups of Boundary Crossing Behavior Across Time" subsection of the "Results" section...
February 9, 2017: Journal of Occupational Health Psychology
https://www.readbyqxmd.com/read/28173847/burden-and-presentation-of-depression-among-newly-diagnosed-individuals-with-tb-in-primary-care-settings-in-ethiopia
#11
Fentie Ambaw, Rosie Mayston, Charlotte Hanlon, Atalay Alem
BACKGROUND: Understanding co-morbidity of depression and tuberculosis (TB) has been limited by challenges in measurement of depression due to overlapping symptoms, use of small hospital samples and uncontrolled analysis. This study was conducted to better understand the burden and presentation of depression, and associated factors in people with TB in primary care settings in Ethiopia. METHODS: We conducted a cross-sectional survey among 657 people newly diagnosed with TB...
February 7, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28173651/-rapidly-progressive-puberty-in-a-patient-with-mosaic-turner-syndrome-a-case-report-and-literature-review
#12
Y Liang, H Wei, X Yu, W Huang, X P Luo
Objective: To explore the clinical characteristics of diagnosis and treatment in patients with Turner syndrome and rapidly progressive puberty. Method: A rare case of rapidly progressive puberty in Turner syndrome with a mosaic karyotype of 45, X/46, X, del(X)(p21)(80%/20%)was diagnosed at Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology in January. 2015. Clinical characteristics and the related literature were reviewed. Original papers on precocious puberty or rapidly progressive puberty in Turner syndrome, published until Apr...
February 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28164415/e-coli-contamination-of-child-complementary-foods-and-association-with-domestic-hygiene-in-rural-bangladesh
#13
Sarker Masud Parvez, Laura Kwong, Musarrat Jabeen Rahman, Ayse Ercumen, Amy J Pickering, Probir K Ghosh, Md Zahidur Rahman, Kishor Kumar Das, Stephen P Luby, Leanne Unicomb
OBJECTIVE: To determine the frequency and concentration of E. coli in child complementary food and its association with domestic hygiene practices in rural Bangladesh. METHOD: 608 households with children <2 years were enrolled. We collected stored complementary food samples, performed spot checks on domestic hygiene and measured ambient temperature in the food storage area. Food samples were analyzed using the IDEXX most probable number (MPN) method with Colilert-18 media to enumerate E...
February 6, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/28160077/effectiveness-of-antiemetic-triplet-therapy-with-aprepitant-palonosetron-and-dexamethasone-for-gynecologic-cancer-patients-receiving-carboplatin-and-paclitaxel-a-prospective-single-arm-study
#14
Naoto Furukawa, Fuminori Ito
PURPOSE: There is no positive evidence for the efficacy of antiemetic triplet therapy with aprepitant (APR), palonosetron (PALO), and dexamethasone (DEX) for moderate emetogenic chemotherapy, especially for gynecologic malignancies. Thus, the present study evaluated the efficacy of this triplet therapy in patients receiving carboplatin and paclitaxel (CP) for gynecologic malignancy. METHODS: Seventy patients with gynecologic cancer receiving CP were enrolled into a prospective single-arm study with APR (125 mg on day 1, 80 mg on days 2-3), PALO (0...
February 4, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28159494/compensatory-structural-and-functional-adaptation-after-radical-nephrectomy-for-renal-cell-carcinoma-according-to-preoperative-stage-of-chronic-kidney-disease-choi-dk-jung-sb-park-bh-jeong-bc-seo-si-jeon-ss-lee-hm-choi-hy-jeon-hg-j-urol-2015-oct-194-4-910-5
#15
Raman Jay, S B Jung, B H Park, B C Jeong, S I Seo, S S Jeon, H M Lee, H Y Choi, H G Jeon
PURPOSE: We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage. MATERIALS AND METHODS: We retrospectively identified 543 patients who underwent radical nephrectomy for renal cell carcinoma between 1997 and 2012. Patients were classified according to preoperative glomerular filtration rate as no chronic kidney disease-glomerular filtration rate 90ml/min/1...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28159493/alcohol-consumption-and-the-risk-of-renal-cancers-in-the-european-prospective-investigation-into-cancer-and-nutrition-epic-wozniak-mb-brennan-p-brenner-dr-overvad-k-olsen-a-tj%C3%A3-nneland-a-boutron-ruault-mc-clavel-chapelon-f-fagherazzi-g-katzke-v-k%C3%A3-hn-t-boeing
#16
Raman Jay, P Brennan, Brenner, K Overvad, A Olsen, A Tjønneland, M C Boutron-Ruault, F Clavel-Chapelon, Fagherazzi, V Katzke, T Kühn, H Boeing, M M Bergmann, A Steffen, A Naska, A Trichopoulou, D Trichopoulos, C Saieva, S Grioni, S Panico, R Tumino, P Vineis, H B Bueno-de-Mesquita, P H Peeters, A Hjartåker, E Weiderpass, L Arriola, E Molina-Montes, E J Duell, C Santiuste, R Alonso de la Torre, A Barricarte Gurrea, T Stocks, M Johansson, B Ljungberg, N Wareham, K T Khaw, R C Travis, A J Cross, N Murphy, E Riboli, G Scelo
Epidemiologic studies have reported that moderate alcohol consumption is inversely associated with the risk of renal cancer. However, there is no information available on the associations in renal cancer subsites. From 1992 to 2010, 477,325 men and women in the European Prospective Investigation into Cancer and Nutrition cohort were followed for incident renal cancers (n = 931). Baseline and lifetime alcohol consumption was assessed by country-specific, validated dietary questionnaires. Information on past alcohol consumption was collected by lifestyle questionnaires...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28158968/a-genome-wide-association-study-in-a-large-f2-cross-of-laying-hens-reveals-novel-genomic-regions-associated-with-feather-pecking-and-aggressive-pecking-behavior
#17
Vanessa Lutz, Patrick Stratz, Siegfried Preuß, Jens Tetens, Michael A Grashorn, Werner Bessei, Jörn Bennewitz
BACKGROUND: Feather pecking and aggressive pecking in laying hens are serious economic and welfare issues. In spite of extensive research on feather pecking during the last decades, the motivation for this behavior is still not clear. A small to moderate heritability has frequently been reported for these traits. Recently, we identified several single-nucleotide polymorphisms (SNPs) associated with feather pecking by mapping selection signatures in two divergent feather pecking lines...
3, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28156439/are-patients-with-cancer-concerned-about-burdening-their-families
#18
Kelly Choi, Ruth Pe Benito, Victoria DeVincenzo, Emily Sassano, Brooke Gruman, Katherine DeMarco, Jose Contreras, Kathryn Tanenbaum, Jennifer Covington, Dhakshila Paramanathan, Stuart L Goldberg
: 86 Background: A diagnosis of advanced cancer frequently thrusts family members into the role of caregiver. Although caregiver burdens have been well documented, less is known about the level of concern borne by the patient (pt) with cancer in placing a family member in this role, known as self-perceived burden (SPB). METHODS: As part of the larger "Living with Cancer" project we prospectively surveyed 1307 pts with advanced malignancies receiving treatment with non-curative intent at 17 New Jersey cancer programs within the Regional Cancer Care Associates network between Sept 2015 and Apr 2016...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28156438/validation-of-the-living-with-cancer-lwc-pro-tool-for-identifying-patients-pts-with-cancer-appropriate-for-end-of-life-care-consultations
#19
Andrew Pecora, Eric Schultz, Hyun Gi Noh, Katherine DeMarco, Jose Contreras, Kelly Choi, Stuart L Goldberg
: 85 Background: End-of-life care (EOLC) discussions for pts with advanced malignancies are often delayed resulting in unwanted, wasteful treatment. COTA Inc has developed a 7-item PRO instrument (LWC) to facilitate identification of pts in distress. A pilot study of 433 pts at a single institution was able to determine a threshold distress score (> 28) correlating with physician assessment of appropriateness for EOLC consultation (2015 ASCO Palliative Care Symposium). METHODS: LWC explores 4 personhood and clinical domains (performance status, pain, burden, and depression)...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152804/engagement-in-a-statewide-oral-oncolytic-collaborative-and-practice-impact
#20
Emily R Mackler, Grayce Galiyas, Laura Petersen, Jamie Lindsay, Teresa M Salgado, Emily Davis, Karen B Farris
: 89 Background: The rapid shift to oral oncolytic therapy presents challenges to oncology practitioners. The purpose of this study is to describe how participation in a statewide oral oncolytic improvement collaborative where best practices and resources were shared can readily impact quality of care as measured by national standards. METHODS: The Michigan Oncology Quality Consortium (MOQC) hosted a series of learning collaborative sessions focused on topics and deployment of resources specific to oral oncolytic management and quality improvement...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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