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https://www.readbyqxmd.com/read/28077240/association-between-community-pharmacy-loyalty-and-persistence-and-implementation-of-antipsychotic-treatment-among-individuals-with-schizophrenia
#1
Frank E Zongo, Jocelyne Moisan, Jean-Pierre Grégoire, Alain Lesage, Anara Richi Dossa, Sophie Lauzier
BACKGROUND: Non-adherence is a major obstacle to optimal treatment of schizophrenia. Community pharmacists are in a key position to detect non-adherence and put in place interventions. Their role is likely to be more efficient when individuals are loyal to a single pharmacy. OBJECTIVE: To assess the association between the level of community pharmacy loyalty and persistence with and implementation of antipsychotic drug treatment among individuals with schizophrenia...
December 28, 2016: Research in Social & Administrative Pharmacy: RSAP
https://www.readbyqxmd.com/read/28076554/-training-of-health-professionals-in-breastfeeding-and-its-association-with-knowledge-skills-and-practices
#2
Patricia Carvalho de Jesus, Maria Inês Couto de Oliveira, José Rodrigo de Moraes
A cross-sectional study was conducted in the 15 hospitals with over 1000 deliveries/year in Rio de Janeiro, Brazil, to verify the association between training of health professionals in breastfeeding and professional knowledge, skills and practices. Interviews were staged with 215 health professionals, 48.4% working in Baby-Friendly Hospitals, by means of a questionnaire adapted from the revalidation instrument of the initiative. The three dichotomized outcomes were subjected to bivariate and multivariate analysis...
January 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28069056/determinants-of-fertility-desire-among-married-or-cohabiting-individuals-in-rakai-uganda-a-cross-sectional-study
#3
Joseph K B Matovu, Fredrick Makumbi, Rhoda K Wanyenze, David Serwadda
BACKGROUND: Recent trends in fertility rates indicate declines in total fertility rate (TFR) in some sub-Saharan African countries. However, countries such as Uganda continue to have a persistently high TFR partly attributed to strong preferences for large family sizes. We explored the factors that influence fertility desire among married or cohabiting individuals in Rakai, a rural district in southwestern Uganda. METHODS: This cross-sectional study of fertility desire (desire to have another child) was nested in a cluster-randomized demand-creation intervention trial for the promotion of couples' HIV counseling and testing uptake among married or cohabiting individuals that was conducted in Rakai district between March 1 and April 30, 2015...
January 10, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28062099/the-trauma-registry-compared-to-all-patient-refined-diagnosis-groups-apr-drg
#4
Jodi Hackworth, Johanna Askegard-Giesmann, Thomas Rouse, Brian Benneyworth
BACKGROUND: Literature has shown there are significant differences between administrative databases and clinical registry data. Our objective was to compare the identification of trauma patients using All Patient Refined Diagnosis Related Groups (APR-DRG) as compared to the Trauma Registry and estimate the effects of those discrepancies on utilization. METHODS: Admitted pediatric patients from 1/2012-12/2013 were abstracted from the trauma registry. The patients were linked to corresponding administrative data using the Pediatric Health Information System database at a single children's hospital...
December 28, 2016: Injury
https://www.readbyqxmd.com/read/28053928/synaptonemal-complex-protein-3-transcript-analysis-in-breast-cancer
#5
Maryam Beigom Mobasheri, Reza Shirkoohi, Mohammad Hossein Modarressi
BACKGROUND: Breast cancer is the most frequent cancer in women. Cancer/Testis antigens are immunogenic proteins ectopically expressed in human neoplasms. Synaptonemal complex protein 3 (SYCP3) belongs to cancer/testis genes family involved in meiotic events and spermatogenesis. The aim of this study was to express analysis of SYCP3 in breast cancer and validate it as a breast cancer biomarker. METHODS: Expression of SYCP3 transcripts in 47 breast tumors, 6 breast cancer cell lines (MCF7, SKBR3, T47D, BT474, MDA-MB-231 and MDA-MB 468), 5 normal breast and 2 testis tissues was studied by Real Time RT-PCR reaction...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28050269/a-cascade-of-thermophilic-enzymes-as-an-approach-to-the-synthesis-of-modified-nucleotides
#6
R S Esipov, Yu A Abramchik, I V Fateev, I D Konstantinova, M A Kostromina, T I Muravyova, K G Artemova, A I Miroshnikov
We propose a new approach for the synthesis of biologically important nucleotides which includes a multi-enzymatic cascade conversion of D-pentoses into purine nucleotides. The approach exploits nucleic acid exchange enzymes from thermophilic microorganisms: ribokinase, phosphoribosylpyrophosphate synthetase, and adenine phosphoribosyltransferase. We cloned the ribokinase gene from Thermus sp. 2.9, as well as two different genes of phosphoribosylpyrophosphate synthetase (PRPP-synthetase) and the adenine phosphoribosyltransferase (APR-transferase) gene from Thermus thermophilus HB27 into the expression vectors, generated high-yield E...
October 2016: Acta Naturae
https://www.readbyqxmd.com/read/28045978/cord-blood-acute-phase-reactants-predict-early-onset-neonatal-sepsis-in-preterm-infants
#7
Leena B Mithal, Hannah L Palac, Ram Yogev, Linda M Ernst, Karen K Mestan
BACKGROUND: Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting in missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation of acute phase reactant (APR) biomarkers in umbilical cord blood at birth may improve EOS detection in preterm infants with intrauterine infection. METHODS: In this nested case-control study, infants (29.7 weeks gestation, IQR: 27.7-32...
2017: PloS One
https://www.readbyqxmd.com/read/28045573/disparities-in-retention-in-hiv-care-among-hiv-infected-young-men-who-have-sex-with-men-in-the-district-of-columbia-2013
#8
Mercedes M Morales-Alemán, Jenevieve Opoku, Ashley Murray, Yzette Lanier, Michael Kharfen, Madeline Y Sutton
PURPOSE: Among young men who have sex with men (YMSM), aged 13-24 years, blacks/African Americans and Hispanics/Latinos are disproportionately affected by HIV, accounting for 58% and 21%, respectively, of diagnoses of HIV infection in the United States. In the District of Columbia (DC), YMSM of color are also disproportionately affected by HIV. National goals are that 80% of HIV-infected persons be retained in HIV care. We analyzed DC surveillance data to examine retention among YMSM living with HIV infection in DC...
January 3, 2017: LGBT Health
https://www.readbyqxmd.com/read/28045293/correction-to-schepers-and-bouton-2015
#9
Scott T Schepers, Mark E Bouton
Reports an error in "Effects of reinforcer distribution during response elimination on resurgence of an instrumental behavior" by Scott T. Schepers and Mark E. Bouton (Journal of Experimental Psychology: Animal Learning and Cognition, 2015[Apr], Vol 41[2], 179-192). The mean R2 responding during the resurgence test in the alternating group in the lower right panel of Figure 4 was incorrect. A corrected figure is given in the correction. (The following abstract of the original article appeared in record 2015-12206-001...
January 2017: Journal of Experimental Psychology. Animal Learning and Cognition
https://www.readbyqxmd.com/read/28033241/financial-resource-utilization-and-mortality-impacts-of-teaching-hospital-status-on-pediatric-patients-admitted-for-sepsis
#10
Benson S Hsu, Benjamin D Meyer, Saquib A Lakhani
BACKGROUND: With the changing healthcare landscape in the United States, teaching hospitals face increasing pressure to provide medical education as well as cost effective care. Our study investigated the financial, resource utilization, and mortality impact of teaching hospital status on pediatric patients admitted with sepsis. METHODS: We conducted a retrospective, weighted statistical analysis of hospitalized children with the diagnosis of sepsis. The Agency for Healthcare Research and Quality (AHRQ) 2009 Kids' Inpatient Database (KID) provided the data for analysis...
December 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28004134/genetic-analysis-and-mapping-of-adult-plant-resistance-loci-to-leaf-rust-in-durum-wheat-cultivar-bairds
#11
Caixia Lan, Bhoja R Basnet, Ravi P Singh, Julio Huerta-Espino, Sybil A Herrera-Foessel, Yong Ren, Mandeep S Randhawa
New leaf rust adult plant resistance (APR) QTL QLr.cim - 6BL was mapped and confirmed the known pleotropic APR gene Lr46 effect on leaf rust in durum wheat line Bairds. CIMMYT-derived durum wheat line Bairds displays an adequate level of adult plant resistance (APR) to leaf rust in Mexican field environments. A recombinant inbred line (RIL) population developed from a cross of Bairds with susceptible parent Atred#1 was phenotyped for leaf rust response at Ciudad Obregon, Mexico, during 2013, 2014, 2015 and 2016 under artificially created epidemics of Puccinia triticina (Pt) race BBG/BP...
December 21, 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28003970/effects-of-resveratrol-on-arpe-19-cell-proliferation-and-migration-via-regulating-the-expression-of-proliferating-cell-nuclear-antigen-p21-p27-and-p38mapk-mmp-9
#12
Xiao-Ning Hao, Wen-Jie Wang, Jian Chen, Qing Zhou, Yi-Xin Qu, Xiao-Yong Liu, Wei Xu
AIM: To explore whether resveratrol (Res) can inhibit human retinal pigment epithelial cell (ARPE-19 cell) proliferation and migration, and to research the molecular mechanisms. METHODS: ARPE-19 cells were pretreated with various concentrations at 0, 50, 100, 150, 200 and 300 µmol/L of Res, and with 0 µmol/L Res as the control for 24, 48 and 72h. The cell proliferation, apoptosis and migration were measured with cell counting kit-8 (CCK-8), flow cytometry, and wound-healing and Transwell assays, respectively...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28003294/acute-uncomplicated-appendicitis-study-rationale-and-protocol-for-a-multicentre-prospective-randomised-controlled-non-inferiority-study-to-evaluate-the-safety-and-effectiveness-of-non-operative-management-in-children-with-acute-uncomplicated-appendicitis
#13
Jane Xu, Yingrui Cyril Liu, Susan Adams, Jonathan Karpelowsky
INTRODUCTION: This article presents an overview of a prospective randomised controlled non-inferiority study designed to evaluate the safety and effectiveness of non-operative management (NOM) with operative management in children with acute uncomplicated appendicitis (AUA). Here, we present the study protocol for this APRES study, a multicentre Australian study. The rationale and details of future analysis, in particular, non-inferiority calculations, cost-effectiveness, feasibility and acceptability of each intervention...
December 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/28002186/barriers-to-universal-prescribing-of-antiretroviral-therapy-by-hiv-care-providers-in-the-united-states-2013-2014
#14
John Weiser, John T Brooks, Jacek Skarbinski, Brady T West, Christopher C Duke, Garrett W Gremel, Linda Beer
INTRODUCTION: HIV treatment guidelines recommend initiating ART regardless of CD4 cell (CD4) count, barring contraindications or barriers to treatment. An estimated 6% of persons receiving HIV care in 2013 were not prescribed antiretroviral therapy (ART). We examined reasons for this gap in the care continuum. METHODS: During 2013-2014, we surveyed a probability sample of HIV care providers, of whom 1,234 returned surveys (64.0% adjusted response rate). We estimated percentages of providers who followed guidelines and their characteristics, and who deferred ART prescribing for any reason...
December 17, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27995876/-evi1-expression-clinical-and-cytogenetical-characteristics-in-447-patients-with-acute-myeloid-leukemia
#15
X F He, Q R Wang, J N Cen, H Y Qiu, A N Sun, S N Chen, D P Wu
Objective: To investigate EVI1 expression and its associated clinical and cytogenetic characteristics in 447 acute myeloid leukemia (AML) patients. Methods: EVI1 expressions were measured in 447 AML cases from Jan. 2007 to Apr. 2015 to couple with clinical, cytogenetic and mutations' characteristics to summarize the features of AMLs with high EVI1 expression. Results: 17.9% of AML were high EVI1 expression (EVI1 (+)), and the remainder low EVI1 expression (EVI1(-)). No significant differences between the two groups in terms of age, sex, hemoglobin level, white blood cell count and platelet count were observed...
November 14, 2016: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/27994615/impairment-of-sulfite-reductase-decreases-oxidative-stress-tolerance-in-arabidopsis-thaliana
#16
Meiping Wang, Yunli Jia, Ziwei Xu, Zongliang Xia
As an essential enzyme in the sulfate assimilation reductive pathway, sulfite reductase (SiR) plays important roles in diverse metabolic processes such as sulfur homeostasis and cysteine metabolism. However, whether plant SiR is involved in oxidative stress response is largely unknown. Here, we show that SiR functions in methyl viologen (MV)-induced oxidative stress in Arabidopsis. The transcript levels of SiR were higher in leaves, immature siliques, and roots and were markedly and rapidly up-regulated by MV exposure...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27994192/mapping-of-stripe-rust-resistance-gene-in-an-aegilops-caudate-introgression-line-in-wheat-and-its-genetic-association-with-leaf-rust-resistance
#17
Puneet Inder Toor, Satinder Kaur, Mitaly Bansal, Bharat Yadav, Parveen Chhuneja
A pair of stripe rust and leaf rust resistance genes was introgressed from Aegilops caudata, a nonprogenitor diploid species with the CC genome, to cultivated wheat. Inheritance and genetic mapping of stripe rust resistance gene in backcrossrecombinant inbred line (BC-RIL) population derived from the cross of a wheat-Ae. caudata introgression line (IL) T291- 2(pau16060) with wheat cv. PBW343 is reported here. Segregation of BC-RILs for stripe rust resistance depicted a single major gene conditioning adult plant resistance (APR) with stripe rust reaction varying from TR-20MS in resistant RILs signifying the presence of some minor genes as well...
December 2016: Journal of Genetics
https://www.readbyqxmd.com/read/27993135/what-are-the-factors-associated-with-human-immunodeficiency-virus-sexually-transmitted-infection-screening-behaviour-among-heterosexual-men-patronising-entertainment-establishments-who-engaged-in-casual-or-paid-sex-results-from-a-cross-sectional-survey-in-an
#18
Raymond Boon Tar Lim, Dede Kam Tyng Tham, Olive N Y Cheung, Bee Choo Tai, Roy Chan, Mee Lian Wong
BACKGROUND: Late presentation of human immunodeficiency virus (HIV) is associated with heterosexual transmission, particularly among heterosexual men in Asia. Although data on HIV/sexually transmitted infection (STI) testing behaviour is increasing, information is still lacking among heterosexual men who receive far lesser attention and are generally invisible in HIV/ STI prevention, particularly in the Asian urban setting. The aim of this study was to assess the prevalence of HIV/STI testing among heterosexual men patronising entertainment establishments (EEs) who engaged in casual or paid sex in Singapore, and the factors associated with this behaviour...
December 19, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27989434/corrigendum-to-reactive-oxygen-species-generated-in-different-compartments-induce-cell-death-survival-or-senescence-free-radic-biol-med-2013-apr-57-176-187
#19
E Panieri, V Gogvadze, E Norberg, R Venkatesh, S Orrenius, B Zhivotovsky
No abstract text is available yet for this article.
January 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27986992/comprehensive-characterization-of-a-theophylline-riboswitch-reveals-two-pivotal-features-of-shine-dalgarno-influencing-activated-translation-property
#20
Wenjing Cui, Jintao Cheng, Shengnan Miao, Li Zhou, Zhongmei Liu, Junling Guo, Zhemin Zhou
Tuneable gene expression controlled by synthetic biological elements is of great importance to biotechnology and synthetic biology. The synthetic riboswitch is a pivotal type of elements that can easily control the heterologous gene expression in diverse bacteria. In this study, the theophylline-dependent synthetic riboswitch and the corresponding variants with varied spacings between Shine-Dalgarno (SD) sequence and start codon were employed to comprehensively characterize the induction and regulation properties through combining a strong promoter aprE in Bacillus subtilis...
December 16, 2016: Applied Microbiology and Biotechnology
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