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https://www.readbyqxmd.com/read/29772306/vascular-endothelial-growth-factor-in-patients-with-schizophrenia-a-systematic-review-and-meta-analysis
#1
REVIEW
Błażej Misiak, Filip Stramecki, Bartłomiej Stańczykiewicz, Dorota Frydecka, Alba Lubeiro
BACKGROUND: Accumulating evidence indicates that schizophrenia might be accompanied by abnormal vascularization. Vascular endothelial growth factor (VEGF) is one of key molecules involved in the development of vessels with vasodilatory activities. OBJECTIVES: We aimed to perform a systematic review and meta-analysis of studies investigating serum or plasma levels of VEGF in patients with schizophrenia and first-episode psychosis (FEP). METHODS: Electronic databases were searched from their inception until 18th Apr 2018...
May 14, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29771940/unplanned-pregnancies-and-contraceptive-use-among-hiv-positive-women-in-care
#2
Madeline Y Sutton, Wen Zhou, Emma L Frazier
Among 230,360 women with diagnosed HIV in the United States (U.S.), ~ 8,500 give birth annually, and unplanned pregnancies (as with HIV-negative women) are prevalent. However, unplanned pregnancies and contraceptive use among HIV-positive women have been understudied. To examine unplanned pregnancies and contraceptive use among HIV-positive women, we used 2013-2014 data from the Medical Monitoring Project (MMP), an HIV surveillance system that produces national estimates for HIV-positive adults in care in the U...
2018: PloS One
https://www.readbyqxmd.com/read/29768955/results-of-a-real-world-study-on-vortioxetine-in-patients-with-major-depressive-disorder-in-south-east-asia-revida
#3
Cheuk Ngen Chin, Azhar Zain, Solaphat Hemrungrojn, Eng Khean Ung, Patanon Kwansanit, Koon Choong Au Yong, Marvin Swee Woon Chong, Chalowat Inpa, Teck Hoe Yen, Boon Beng David Yeoh, Liam Kai Tay, Carmina Bernardo, Lionel Chee-Chong Lim, Chin Hong Yap, Calvin Fones, Ashwini Nayak, Lars Nelleman
OBJECTIVE: The REVIDA study aimed to assess the evolution of major depression symptoms in South East Asian (SEA) patients treated with vortioxetine for major depression in real-world clinical practice. METHODS: This non-interventional study was conducted from Aug 2016 to Apr 2017. A total of 138 patients (aged 18-65 years) with an active episode of major depression were recruited from Malaysia, Philippines, Singapore, and Thailand. Vortioxetine was initiated on the first visit and patients were followed for 3 months...
May 17, 2018: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29761295/a-startling-acoustic-stimulus-facilitates-voluntary-lower-extremity-movements-and-automatic-postural-responses-in-people-with-chronic-stroke
#4
Milou J M Coppens, Jolanda M B Roelofs, Nicole A J Donkers, Jorik Nonnekes, Alexander C H Geurts, Vivian Weerdesteyn
A startling acoustic stimulus (SAS) involuntary releases prepared movements at accelerated latencies, known as the StartReact effect. Previous work has demonstrated intact StartReact in paretic upper extremity movements in people after stroke, suggesting preserved motor preparation. The question remains whether motor preparation of lower extremity movements is also unaffected after stroke. Here, we investigated StartReact effects on ballistic lower extremity movements and on automatic postural responses (APRs) following perturbations to standing balance...
May 14, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29756592/three-year-follow-up-study-in-patients-with-guillain-barr%C3%A3-syndrome
#5
Vesna Martic, Ivo Bozovic, Ivana Berisavac, Ivana Basta, Stojan Peric, Milica Babic, Sonja Lukic Rajic, Bogdan Bjelica, Olivera Stojiljkovic Tamas, Aleksandar Stojanov, Marija Grunauer, Mina Cobeljic, Nenad Komatina, Vanja Djuric, Milutin Petrovic, Balsa Vujovic, Aleksandra Dominovic Kovacevic, Gordana Djordjevic, Dejana Jovanovic, Zorica Stevic
A majority of patients with Guillain-Barré syndrome (GBS) have tendency of a good recovery. Our aim was to evaluate the outcome of the disease 1 and 3 years after GBS symptom onset. METHODS: During 2014, GBS was diagnosed in 82 patients in seven tertiary healthcare centers. Neurological follow-up was conducted in 57 (70%) patients after 1 year, and in 54 (66%) after 3 years. Functional disability was estimated according to the GBS disability scale (GDS), with a score of 0-3 indicating mild disability and a score of 4-6 indicating severe disability during acute phase, whereas a score >1 indicated poor recovery on follow-ups...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29756589/effect-of-combination-therapy-with-neuroprotective-and-vasoprotective-agents-on-cerebral-ischemia
#6
Jiping Yang, Bei Yang, Baoxin Xiu, Jinchong Qi, Huaijun Liu
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. METHODS: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29755788/factors-associated-with-participation-in-pulmonary-tuberculosis-screening-using-chest-x-ray-among-diabetes-mellitus-type-ii-patients-in-denpasar-bali-indonesia
#7
I Gusti Ngurah Edi Putra, Putu Ayu Swandewi Astuti, I Ketut Suarjana, Ketut Hari Mulyawan, I Made Kerta Duana, Ni Made Dian Kurniasari, I Wayan Gede Artawan Eka Putra
Diabetes mellitus (DM) increases the risk of developing pulmonary tuberculosis (TB) disease. Therefore, pulmonary TB screening among DM patients is essential. This study aimed to identify factors associated with participation of DM type II patients in pulmonary TB screening using chest X-ray. This was a cross-sectional analytic study and was part of TB-DM screening study in Denpasar, Bali, Indonesia. The sample consisted of 365 DM type II patients selected by quota sampling among DM type II patients joining the screening program from January until March 2016 in 11 public health centres in Denpasar...
2018: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29755668/mutant-p53-tunes-the-nrf2-dependent-antioxidant-response-to-support-survival-of-cancer-cells
#8
Kamil Lisek, Elena Campaner, Yari Ciani, Dawid Walerych, Giannino Del Sal
NRF2 (NFE2L2) is one of the main regulators of the antioxidant response of the cell. Here we show that in cancer cells NRF2 targets are selectively upregulated or repressed through a mutant p53-dependent mechanism. Mechanistically, mutant p53 interacts with NRF2, increases its nuclear presence and resides with NRF2 on selected ARE containing gene promoters activating the transcription of a specific set of genes while leading to the transcriptional repression of others. We show that thioredoxin ( TXN) is a mutant p53-activated NRF2 target with pro-survival and pro-migratory functions in breast cancer cells under oxidative stress, while heme oxygenase 1 ( HMOX1) is a mutant p53-repressed target displaying opposite effects...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29753222/bacterial-community-structure-in-atmospheric-particulate-matters-of-different-sizes-during-the-haze-days-in-xi-an-china
#9
Rui Lu, Yanpeng Li, Wanxin Li, Zhengsheng Xie, Chunlan Fan, Pengxia Liu, Shunxi Deng
Serious air pollution events have frequently occurred in China associated with the acceleration of urbanization and industrialization in recent years. Exposure to atmospheric particulate matter (PM) of high concentration can lead to adverse effects on human health. Airborne bacteria are important constituents of microbial aerosols and contain lots of pathogens. However, variations in bacterial community structure in atmospheric PM of different sizes (PM2.5 , PM10 and TSP) have not yet been explored. In this study, PM samples of different sizes were collected during the hazy days from Jul...
May 9, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29747650/hospital-financing-of-ischaemic-stroke-determinants-of-funding-and-usefulness-of-drg-subcategories-based-on-severity-of-illness
#10
Sarah Dewilde, Lieven Annemans, Hilde Pincé, Vincent Thijs
BACKGROUND: Several Western and Arab countries, as well as over 30 States in the US are using the "All-Patient Refined Diagnosis-Related Groups" (APR-DRGs) with four severity-of-illness (SOI) subcategories as a model for hospital funding. The aim of this study is to verify whether this is an adequate model for funding stroke hospital admissions, and to explore which risk factors and complications may influence the amount of funding. METHODS: A bottom-up analysis of 2496 ischaemic stroke admissions in Belgium compares detailed in-hospital resource use (including length of stay, imaging, lab tests, visits and drugs) per SOI category and calculates total hospitalisation costs...
May 11, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29745351/evaluation-of-the-effectiveness-of-a-latrine-intervention-in-the-reduction-of-childhood-diarrhoeal-health-in-nyando-district-kisumu-county-kenya
#11
C Babb, N Makotsi, I Heimler, R C Bailey, R C Hershow, P Masanga, S D Mehta
Community-led total sanitation (CLTS) is an intervention that strives to end the practice of open defaecation. This study measured the effectiveness of CLTS in Nyando District by examining the association between community open defaecation-free (ODF) status and childhood diarrhoeal illness. A cross-sectional study design was used among households with children ⩽5 years old to ascertain information on acute diarrhoea in the past year (outcome), sanitation and health behaviours. Water testing was conducted to determine Escherichia coli and turbidity levels for 55 water sources...
May 10, 2018: Epidemiology and Infection
https://www.readbyqxmd.com/read/29742255/circulation-levels-of-acute-phase-proteins-pentraxin-3-and-serum-amyloid-a-in-atherosclerosis-have-correlations-with-periodontal-inflamed-surface-area
#12
Başak Temelli, Zuhal Yetkin Ay, Hasan Basri Savaş, Fatih Aksoy, Duygu Kumbul Doğuç, Ersin Uskun, Ercan Varol
Objectives One of the plausible mechanisms in the relationship between periodontitis and coronary artery disease (CAD) is the systemic inflammatory burden comprised of circulating cytokines/mediators related to periodontitis. This study aims to test the hypothesis that periodontal inflamed surface area (PISA) is correlated with higher circulating levels of acute phase reactants (APR) and pro-inflammatory cytokines/mediators and lower anti-inflammatory cytokines/mediators in CAD patients. Material and Methods Patients aged from 30 to 75 years who underwent coronary angiography with CAD suspicion were included...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29736984/estimation-of-the-bacteriocin-cole7-conjugation-based-kill-anti-kill-antimicrobial-system-by-real-time-pcr-fluorescence-staining-and-bioluminescence-assays
#13
I L Maslennikova, M V Kuznetsova, N Toplak, I V Nekrasova, D Žgur Bertok, M Starčič Erjavec
The efficiency of the bacteriocin, colicin ColE7, bacterial conjugation-based "kill" - "anti-kill" antimicrobial system, was assessed using real-time PCR, flow cytometry and bioluminescence. The ColE7 antimicrobial system consists of the genetically modified Escherichia coli strain Nissle 1917 harbouring a conjugative plasmid (derivative of the F-plasmid) encoding the "kill" gene (ColE7 activity gene) and a chromosomally encoded "anti-kill" gene (ColE7 immunity gene)...
May 7, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29736254/impact-of-pharmacist-counseling-on-reducing-instances-of-adverse-events-that-can-affect-the-quality-of-life-of-chemotherapy-outpatients-with-breast-cancer
#14
Kazuhide Tanaka, Akiyo Hori, Tomoya Tachi, Tomohiro Osawa, Katsuhiro Nagaya, Teppei Makino, Seiji Inoue, Masahiro Yasuda, Takashi Mizui, Takumi Nakada, Chitoshi Goto, Hitomi Teramachi
Background: In recent years, cancer chemotherapy is being conducted at outpatient clinics, wherein pharmacists are involved with patient guidance and management of adverse events as experts in medication therapy. Therefore, we clarified the influence of interventions by pharmacists during counseling of patients with cancer on patients' quality of life. Methods: To determine this influence, we conducted a survey to assess the quality of life of 39 patients with breast cancer who underwent their initial course of outpatient cancer chemotherapy at Gifu Municipal Hospital...
2018: Journal of Pharmaceutical Health Care and Sciences
https://www.readbyqxmd.com/read/29734813/place-of-origin-associated-with-depressive-symptoms-in-health-professionals-performing-social-health-service-in-ancash-peru-2015
#15
Renee Montesinos-Segura, Jesus Maticorena-Quevedo, Kocfa Chung-Delgado, Reneé Pereyra-Elías, Alvaro Taype-Rondan, Percy Mayta-Tristán
INTRODUCTION: Health professionals performing their social health service (SHS) in rural communities could be at risk of developing depression. Moreover, those who migrate from farther places to perform their SHS could have an increased risk. The objective of this study was to evaluate the association between place of origin and the presence of depressive symptoms, in health professionals performing rural social health service (SHS) in Ancash, Peru. METHODS: This was a cross-sectional study...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29734218/depressive-symptoms-and-problematic-alcohol-and-other-substance-use-in-1-476-gay-bisexual-and-other-men-who-have-sex-with-men-at-three-research-sites-in-kenya
#16
Christine Korhonen, Makobu Kimani, Elizabeth Wahome, Fredrick Otieno, Duncan Okall, Robert C Bailey, Gary W Harper, Robert R Lorway, Monika Doshi, John Mathenge, Joshua Kimani, Eduard J Sanders, Susan M Graham
OBJECTIVE: Information on mental health and substance use challenges among gay, bisexual, and other men who have sex with men (GBMSM) is needed to focus resources on these issues and optimize services for HIV prevention and care. We determined factors associated with depressive symptoms and problematic alcohol and other substance use among GBMSM in Kenya. METHODS: Self-identified GBMSM in three HIV research studies in Kenya provided information on depressive symptoms (PHQ-9), alcohol use (AUDIT), and other substance use (DAST-6)...
May 3, 2018: AIDS
https://www.readbyqxmd.com/read/29720135/compliance-with-iron-and-folic-acid-supplementation-ifas-and-associated-factors-among-pregnant-women-results-from-a-cross-sectional-study-in-kiambu-county-kenya
#17
Mary Wanjira Kamau, Waithira Mirie, Samuel Kimani
BACKGROUND: Macro and micronutrients including iron and folic acid deficiencies are prevalent in Kenya, particularly during pregnancy resulting in anaemia. Despite efforts to control anaemia in pregnancy by adopting Iron and Folic Acid Supplementation (IFAS), this public health problem has persisted contributing to significant morbidity and mortality. The problem notwithstanding, there is poor IFAS compliance, whose reasons remain poorly understood, calling for their investigations. We sought to determine compliance status with IFAS and associated factors among pregnant women...
May 2, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29718756/healthcare-resource-utilization-and-costs-among-psoriasis-patients-treated-with-biologics-overall-and-by-disease-severity
#18
Mwangi J Murage, Amanda Anderson, Susan A Oliveria, Deborah Casso, Clement K Ojeh, Talia M Muram, Joseph F Merola, Andre B Araujo
AIMS: Describe healthcare resource utilization (HCRU) and costs among biologic-treated psoriasis patients in the US, overall and by disease severity. MATERIALS AND METHODS: IQVIA PharMetrics Plus administrative claims data were linked with Modernizing Medicine Data Services Electronic Health Record data and used to select adult psoriasis patients between 01-Apr-2010 and 31-Dec-2014. Eligible patients were classified by disease severity (mild, moderate, severe) using a hierarchy of available clinical measures...
May 2, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29717080/correction-prima-1met-apr-246-displays-high-antitumor-activity-in-multiple-myeloma-by-induction-of-p73-and-noxa
#19
(no author information available yet)
No abstract text is available yet for this article.
May 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29708419/illusionment-and-disillusionment-foundational-illusions-and-the-loss-of-a-world
#20
Alfred Margulies
One can only be disillusioned if once one lived within illusions-and so disillusionment is always after the fact ( après coup or nachträglich), as illusions come into view even as they are crumbling within. With a crisis of disillusionment-or existential disillusionment-one falls away from a coherence of meaning, revealing a system of intertwined fundamental illusions that had always been lived within and implicit, part of one's being-in-the-world, and that now seem broken, strange, and uncanny. This way of being that one recognizes only retrospectively may be called "illusionment," a state of being apprehended in the very process of its falling apart...
April 2018: Journal of the American Psychoanalytic Association
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