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https://www.readbyqxmd.com/read/29237405/prevalence-and-characteristics-of-hereditary-non-polyposis-colorectal-cancer-hnpcc-syndrome-in-immigrant-asian-colorectal-cancer-patients
#1
Jasmine Lee, Yin-Yi Xiao, Yan Yu Sun, Jasminka Balderacchi, Bradley Clark, Jatin Desani, Vivek Kumar, Angela Saverimuthu, Khin Than Win, Yiwu Huang, Yiqing Xu
BACKGROUND: The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2, and EPCAM. A non-hereditary, acquired process of hypermethylation of the MLH1 promoter can also lead to silencing of MLH1 protein expression. Diagnosis of HNPCC in patients with colorectal and other related cancers is important in the clinical treatment and surveillance of related cancers...
December 13, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29236228/population-pharmacokinetic-pharmacodynamic-modeling-of-ropivacaine-in-spinal-anesthesia
#2
Zoubir Djerada, Catherine Feliu, Yoann Cazaubon, Faouzi Smati, Philippe Gomis, Dominique Guerrot, Beny Charbit, Olivier Fernandes, Jean-Marc Malinovsky
BACKGROUND: Ropivacaine is frequently used in spinal anesthesia but the relationship between plasma concentrations and sensory block level remains unknown. OBJECTIVE: The aim of this study was to assess the relationship between plasma ropivacaine concentrations and effects during spinal anesthesia. METHODS: Sixty patients aged between 18 and 82 years were included in this study after providing written informed consent. Patients were randomly assigned to receive intrathecal administration of ropivacaine 15, 20 or 25 mg...
December 13, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29235533/a-generic-standard-additions-based-method-to-determine-endogenous-analyte-concentrations-by-immunoassays-to-overcome-complex-biological-matrix-interference
#3
Susan Pang, Simon Cowen
We describe a novel generic method to derive the unknown endogenous concentrations of analyte within complex biological matrices (e.g. serum or plasma) based upon the relationship between the immunoassay signal response of a biological test sample spiked with known analyte concentrations and the log transformed estimated total concentration. If the estimated total analyte concentration is correct, a portion of the sigmoid on a log-log plot is very close to linear, allowing the unknown endogenous concentration to be estimated using a numerical method...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29232630/opioid-drugs-and-stercoral-perforation-of-the-colon-case-report-and-review-of-literature
#4
Renée Poitras, Daun'Lee Warren, Sylvanus Oyogoa
INTRODUCTION: Stercoral perforation of the colon is a rare pathology, which is believed to be caused by an increased intraluminal pressure created by a fecaloma. Opioid induced constipation is a rare and often unsuspected cause of colonic perforation. PRESENTATION OF CASE: We report the case of a 58-year-old woman, who presented to the emergency department (ED) with severe hypotension, abdominal pain and gastrointestinal bleeding. She was found to have a diffusely tender and distended abdomen...
December 7, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29232245/intense-68ga-psma-uptake-in-diverticulum-of-the-sigmoid-colon
#5
Mads Ryø Jochumsen, Kirsten Bouchelouche
We present a case of a diverticulum of the sigmoid colon with intense prostate-specific membrane antigen (PSMA) activity on Ga-PSMA PET/CT. CT scan and colonoscopy showed no signs of inflammation or malignancy. This case presents an addition to the collection of benign pitfalls when reporting PSMA PET/CT; however, a Ga-PSMA up-taking focus in the colon should always cause further examination, as malignant etiology must be ruled out.
December 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29231778/case-study-of-an-epidemiological-approach-dissecting-historical-soybean-sclerotinia-stem-rot-observations-and-identifying-environmental-predictors-of-epidemics-and-yield-loss
#6
Mamadou Lamine Fall, John F Boyse, Dechun Wang, Jamie F Willbur, Damon Smith, Martin I Chilvers
Sclerotinia sclerotiorum is a significant threat to soybean production worldwide. In this study, an epidemiological approach was used to examine 11 years of historical data from a soybean management performance trial in order to advance our understanding of Sclerotinia stem rot (SSR) development and to identify environmental predictors of SSR epidemics and associated yield losses. Recursive partitioning analysis suggested that average air temperature and total precipitation in July were the most significant variables associated with disease severity...
December 12, 2017: Phytopathology
https://www.readbyqxmd.com/read/29230969/laparoscopic-colectomy-after-self-expanding-metallic-stent-placement-through-the-ileocecal-valve-for-right-sided-malignant-colonic-obstruction-a-case-report
#7
Hiroshi Takeyama, Katsuki Danno, Yuya Kogita, Takahiko Nishigaki, Masafumi Yamashita, Masami Yamazaki, Tsuyoshi Yamakita, Akihiro Nishihara, Minako Hoshi, Hirokazu Taniguchi, Masayo Mizutani, Itsuko Nakamichi, Mamoru Yura, Kimimasa Ikeda, Eiji Kurokawa
A 78-year-old man with a history of open sigmoidectomy for sigmoid cancer presented with abdominal pain and vomiting. Abdominal multi-detector CT revealed an obstructive ileocecal tumor with distended small bowel on the oral side. We performed emergency drainage using a transnasal decompression tube, and 2 days later, we conducted a colonoscopic examination, which lead to a provisional diagnosis of obstruction with a malignant tumor invading the ileocecal valve. We then placed a self-expanding metallic stent (SEMS) through the ileocecal valve...
December 12, 2017: Asian Journal of Endoscopic Surgery
https://www.readbyqxmd.com/read/29230128/sigmoid-colonic-polyp-as-initial-presentation-of-metastatic-papillary-renal-cell-carcinoma
#8
Andrew C Berry, Rahman Nakshabendi, Ozdemir Kanar, Wayne Cai, Mohan Persaud
Background: Upon initial presentation, 25%-30% of patients with renal cell carcinoma have metastatic disease. Metastasis to the gastrointestinal tract is rare, but when it occurs, the large bowel is the least common site. Case Report: A 75-year-old white male presented with vague abdominal symptoms and worsening hemoglobin and hematocrit levels. Colonoscopy revealed a polyp in the distal portion of the sigmoid colon. Histologic and immunohistochemical analysis suggested metastatic papillary renal cell carcinoma...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229637/elucidating-the-pharmacokinetics-pharmacodynamics-of-aerosolized-colistin-against-multidrug-resistant-acinetobacter-baumannii-and-klebsiella-pneumoniae-in-a-mouse-lung-infection-model
#9
Yu-Wei Lin, Qi Tony Zhou, Mei-Ling Han, Ke Chen, Nikolas J Onufrak, Jiping Wang, John D Turnidge, Benjamin P Howden, Alan Forrest, Hak-Kim Chan, Jian Li
Pharmacokinetics/pharmacodynamics (PK/PD) of aerosolized colistin was investigated against Acinetobacter baumannii and Klebsiella pneumoniae over 24 h in a neutropenic mouse lung infection model. Dose fractionation studies were performed over 2.64 to 23.8 mg/kg/day, and the data were fitted to a sigmoid inhibitory model. AUC/MIC in the epithelial lining fluid was the most predictive PK/PD index for aerosolized colistin against both pathogens. Our study provides important pharmacological information for optimizing aerosolized colistin...
December 11, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29229358/thigh-necrotizing-fasciitis-secondary-to-perforated-sigmoid-diverticulitis
#10
Jorge Sancho Muriel, Matteo Frasson, Salvador Pous, Eduardo García-Granero
No abstract text is available yet for this article.
December 8, 2017: Cirugía Española
https://www.readbyqxmd.com/read/29229157/long-term-outcomes-of-sigmoid-diverticulitis-a-single-center-experience
#11
Ido Mizrahi, Abbas Al-Kurd, Katya Chapchay, Yael Ag-Rejuan, Natalia Simanovsky, Ahmed Eid, Haggi Mazeh
BACKGROUND: During the last decade, guidelines for the treatment of sigmoid diverticulitis have dramatically changed. The aim of this study is to report the long-term outcomes of patients treated for diverticulitis at a nonspecialized single center. MATERIALS AND METHODS: After obtaining institutional review board approval, medical records of all patients admitted to our institution with the diagnosis of sigmoid diverticulitis between 1998 and 2008 were reviewed...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228373/medical-treatment-or-surgery-for-colorectal-endometriosis-results-of-a-shared-decision-making-approach
#12
Paolo Vercellini, Maria Pina Frattaruolo, Riccardo Rosati, Dhouha Dridi, Anna Roberto, Paola Mosconi, Olga De Giorgi, Fulvia Milena Cribiù, Edgardo Somigliana
STUDY QUESTION: What is the degree of patient satisfaction in women with symptomatic colorectal endometriosis who choose medical or surgical treatment after a shared decision-making (SDM) process? SUMMARY ANSWER: The degree of satisfaction with treatment was high both in women who chose medical treatment with a low-dose oral contraceptive (OCP) or a progestin, and in those who chose to undergo surgical resection of bowel endometriosis. WHAT IS KNOWN ALREADY: Hormonal therapies and surgery for colorectal endometriosis have been investigated in non-comparative studies with inconsistent results...
December 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29228130/acute-retroviral-syndrome-is-associated-with-high-viral-burden-cd4-depletion-and-immune-activation-in-systemic-and-tissue-compartments
#13
Trevor A Crowell, Donn J Colby, Suteeraporn Pinyakorn, James L K Fletcher, Eugène Kroon, Alexandra Schuetz, Shelly J Krebs, Bonnie M Slike, Louise Leyre, Nicolas Chomont, Linda L Jagodzinski, Irini Sereti, Netanya S Utay, Robin Dewar, Rungsun Rerknimitr, Nitiya Chomchey, Rapee Trichavaroj, Victor G Valcour, Serena Spudich, Nelson L Michael, Merlin L Robb, Nittaya Phanuphak, Jintanat Ananworanich
Background: Many individuals with acute HIV infection (AHI) experience acute retroviral syndrome (ARS), which is associated with adverse long-term clinical outcomes. We characterized clinical, virologic, and immunologic features of ARS and described the impact of early antiretroviral therapy (ART) initiation. Methods: Participants presenting for voluntary HIV testing were enrolled during AHI in Bangkok, Thailand. ARS was defined by ≥3 qualifying signs/symptoms...
December 7, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29227561/green-synthesis-of-a-new-al-mof-based-on-the-aliphatic-linker-mesaconic-acid-structure-properties-and-in-situ-crystallisation-studies-of-al-mil-68-mes
#14
Helge Reinsch, Thomas Homburg, Niclas Heidenreich, Dominik Froehlich, Stefan Henninger, Michael Wark, Norbert Stock
A new aluminium MOF based on the short aliphatic linker molecule mesaconic acid (H2Mes; methylfumaric acid) is reported. Al-MIL-68-Mes with composition [Al(OH)(O2C-C3H4-CO2)]·nH2O is obtained after short reaction times of 45 minutes under mild, aqueous synthesis conditions (95 °C). It exhibits a kagome-like framework structure with large hexagonal and small trigonal channels (diameters of ~ 6 and ~2 Å, respectively) and a specific surface area of SBET ≈ 1040 m2/g (VMIC = 0.42 cm3/g). A sigmoidal vapour sorption isotherm for water and uptakes of water and methanol above 30 wt% were observed...
December 11, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29226661/completely-responsive-multiple-liver-recurrence-of-colon-cancer-treated-using-chemotherapy-with-oral-s-1-and-oxaliplatin-plus-bevacizumab-a-case-report
#15
Akira Kabashima, Koichi Kimura, Kensakuet Sanefuji, Soichiro Maekawa
Although chemotherapy with oral S-1and oxaliplatin (SOX) plus bevacizumab (bev) is safe and feasible for patients with advanced or recurrent colorectal cancer, it is difficult to achieve a complete response (CR) using only chemotherapy. A 67-year-old man underwent endoscopic mucosal resection and additional sigmoidectomy (D2 dissection) for submucosal invasive sigmoid colon cancer. Multiple liver metastases were diagnosed 1.5 years later, and chemotherapy with SOX + bev was initiated. Computed tomography (CT) after the end of the third course revealed reduced liver recurrence...
January 2017: Fukuoka Igaku Zasshi, Hukuoka Acta Medica
https://www.readbyqxmd.com/read/29226475/a-double-scope-method-for-creating-a-straight-submucosal-tunnel-during-peroral-endoscopic-myotomy
#16
Hironari Shiwaku, Kanefumi Yamashita, Suguru Hasegawa
Peroral endoscopic myotomy (POEM) is a revolutionary treatment for achalasia.1-3 It involves creating a submucosal tunnel directly to the stomach side; theoretically, a straight tunnel can be obtained by creating it perpendicular to the inner annulus muscle. Clinically, this is not always easy; therefore, we introduced a new method for controlling the submucosal tunnel direction in which a small-diameter endoscope is inserted along with the main endoscope. This allows us to check the illumination of the main scope in the submucosal layer, which can be particularly useful when treating a sigmoid-type anomaly with a highly flexed esophagus...
December 11, 2017: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29226128/amplitude-latency-and-peak-velocity-in-accommodation-and-disaccommodation-dynamics
#17
Antonio J Del Águila-Carrasco, José J Esteve-Taboada, Eleni Papadatou, Teresa Ferrer-Blasco, Robert Montés-Micó
The aim of this work was to ascertain whether there are differences in amplitude, latency, and peak velocity of accommodation and disaccommodation responses when different analysis strategies are used to compute them, such as fitting different functions to the responses or for smoothing them prior to computing the parameters. Accommodation and disaccommodation responses from four subjects to pulse changes in demand were recorded by means of aberrometry. Three different strategies were followed to analyze such responses: fitting an exponential function to the experimental data; fitting a Boltzmann sigmoid function to the data; and smoothing the data...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225733/colorectal-surgeon-consensus-with-diverticulitis-clinical-practice-guidelines
#18
Javariah Siddiqui, Assad Zahid, Jonathan Hong, Christopher John Young
AIM: To determine the application of clinical practice guidelines for the current management of diverticulitis and colorectal surgeon specialist consensus in Australia and New Zealand. METHODS: A survey was distributed to 205 colorectal surgeons in Australia and New Zealand, using 22 hypothetical clinical scenarios. RESULTS: The response rate was 102 (50%). For 19 guideline-based scenarios, only 11 (58%) reached consensus (defined as > 70% majority opinion) and agreed with guidelines; while 3 (16%) reached consensus and did not agree with guidelines...
November 27, 2017: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29225684/colon-cancer-presenting-as-pseudo-obstruction-during-pregnancy-a-case-report
#19
Reeva Makhijani, Vicky H Bhagat, Mariam Fayek
The incidence of colorectal cancer in pregnancy is between 0.002 and 0.008%. Diagnosis is often delayed as symptoms of colorectal cancer can mimic as common complaints of pregnancy. We present the case of a 29-year-old with a history of chronic constipation who presented in the second trimester with abdominal pain, inability to tolerate anything orally and no bowel movement in more than three weeks. Non-contrast MRI at presentation failed to show an obstructing mass. Patient was treated conservatively for presumed pseudo-obstruction secondary to worsening constipation from chronic ondansetron use and pregnancy...
December 2017: Obstetric Medicine
https://www.readbyqxmd.com/read/29225513/an-abrupt-bleeding-of-the-anteriorly-displaced-sigmoid-sinus-a-rare-complication-of-myringoplasty
#20
Sarah Zaher Addeen, Mohammad Al-Mohammad
Background: The location of the sigmoid sinus within the mastoid cavity is quite variable. An anteriorly- displaced vertical segment of the sigmoid sinus constitutes an uncommon but dangerous anatomical variation that surgeons rarely encounter during surgery. In this variation, the sigmoid sinus lays underneath a very thin bony flap, which makes it easily damaged. Thus, an abrupt fatal bleeding might occur. Despite the many hypotheses about its origin (Chronic otitis media, hypopneumatization, etc...
2017: BMC Ear, Nose, and Throat Disorders
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