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https://www.readbyqxmd.com/read/28723110/portable-sensor-for-the-detection-of-choline-and-its-derivatives-based-on-silica-isoporous-membrane-and-gellified-nanointerfaces
#1
Lisiqi Xie, Xiao Huang, Bin Su
A portable amperometric ion sensor was fabricated by integrating silica isoporous membrane (SIM) and organogel composed of polyvinyl chloride and 1,2-dichloroethane (PVC-DCE) on a 3D-printed polymer chip. The detection of ionic species in aqueous samples could be accomplished by adding a microliter of sample droplet to the sensor and by identifying the ion-transfer potential and current magnitude at the water/organogel interface array templated by SIM. Thanks to the ultrasmall channel size (2-3 nm in diameter), high channel density (4 × 10(8) μm(-2)), and ultrathin thickness (80 nm) of SIM, the ensemble of nanoscopic water/organogel (nano-W/Gel) interface array behaved like a microinterface with two back-to-back hemispherical mass diffusion zones...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28721463/exstrophy-bladder-reconstruction-or-diversion-for-the-underprivileged
#2
REVIEW
Yogesh Kumar Sarin, Virender Sekhon
The surgical techniques for management of bladder exstrophy epispadias complex have evolved from staged reconstruction, complete primary repair to radical mobilization. Post-operative complications add to the multiplicity of surgical procedures at each step. The end results are variable with many achieving continence rates of 85-89% only after bladder augmentation and clean intermittent catheterization. The situation is further complicated in resource-poor settings, where illiteracy and poverty are the driving factors for choosing a single operative procedure for creation of low pressure reservoir aiming at upper tract preservation and good primary continence...
July 18, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28721104/case-report-of-a-computerized-tomography-sign-in-strongyloides-stercoralis-infection
#3
Sandeep Yerra, Pradeep Yarra
This is a case of strongyloidiasis showing colon enhancement on a computerized tomography (CT) scan. The patient presented with chief complaints of diarrhea and abdominal pain. She gave a history of recent travel to El Salvador and her stool was positive for Strongyloides stercoralis. A CT scan revealed a circumferential enhancement of the sigmoid colon. This CT sign was unusual in strongyloidiasis and when combined with the symptoms, caused us to rule out inflammatory bowel disease and shock bowel. Stool examination revealed ova and parasites of Strongyloides stercoralis...
2017: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/28720994/early-migration-of-bone-graft-causing-sigmoid-colon-perforation-after-trans-foraminal-lumbar-interbody-fusion
#4
Bhavuk Garg, Amit Singla, Sahil Batra, Senthil Kumar
BACKGROUND: Tran foraminal lumbar interbody fusion (TLIF) is a well accepted and standard technique of achieving spinal fusion using pedicle screws, cage and bone graft. We are presenting here a case of L4-L5 lumbar canal stenosis managed with TLIF that presented with sigmoid colon perforation due to bone graft migration 4 days after surgery. CASE REPORT: A 35 years old female underwent open TLIF (from right side) with decompression for L4-L5 lumbar canal stenosis...
April 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/28720741/-transvenous-embolization-by-direct-puncture-of-the-superior-sagittal-sinus-using-indocyanine-green-icg-videoangiography-for-treatment-of-dural-arteriovenous-fistula-of-the-transverse-sigmoid-sinus-a-case-report
#5
Jo Matsuzaki, Kenichi Kono, Arisa Umesaki, Yojiro Kashimura, Hiroaki Matsumoto, Tomoaki Terada
We report a case of dural arteriovenous fistula at the left transverse sinus and sigmoid sinus(TS-dAVF), which was treated with transvenous embolization(TVE)by direct puncture of the superior sagittal sinus(SSS)under indocyanine green(ICG)fluoroscopic guidance. A 71-year-old woman presented with pulsatile tinnitus and progressive dementia. A left TS-dAVF with retrograde SSS and cortical venous reflux(Cognard type IIb)was demonstrated on cerebral angiography. The left internal jugular vein and distal portion of the right transverse sinus were occluded...
July 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28719359/levodopa-in-parkinson-s-disease-a-review-of-population-pharmacokinetics-pharmacodynamics-analysis
#6
Amélie Marsot, Romain Guilhaumou, Jean Philippe Azulay, Olivier Blin
BACKGROUND: Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease. Although levodopa remains the single effective agent in the management of Parkinson's disease, the accurate determination of this optimal dosage is complicated by marked between-subject and between-occasion variability in this population.  This review presents a synthesis of the population pharmacokinetic and pharmacodynamic models of levodopa described in Parkinson's disease...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28718631/a-copper-ii-paddlewheel-metal-organic-framework-with-exceptional-hydrolytic-stability-and-selective-adsorption-and-detection-ability-of-aniline-in-water
#7
Ya Chen, Bin Wang, Xiaoqing Wang, Lin-Hua Xie, Jinping Li, Yabo Xie, Jian-Rong Jeff Li
Copper(II) paddlewheel based metal-organic frameworks (CP-MOFs) represent a unique subclass of MOFs with highly predictable porous structures, facile syntheses, and functional open metal sites. However, lack of high hydrolytic stability is an obstacle for CP-MOFs in many practical applications. In this work, we report a new CP-MOF, [Cu4(tdhb)] (BUT-155), which is constructed from a judiciously designed carboxylate ligand with high coordination connectivity (octatopic), abundant hydrophobic substituents (six methyl groups), and substituent constrained geometry (tetrahedral backbone), tdhb8- (H8tdhb = 3,3',5,5'-tetra(3,5-dicarboxyphenyl)-2,2',4,4',6,6'-hexamethylbiphenyl))...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718456/graphene-oxide-and-dna-aptamer-based-sub-nanomolar-potassium-detecting-optical-nanosensor
#8
Debopam Datta, Ketaki Sarkar, Souvik Mukherjee, Xenia Meshik, Michael A Stroscio, Mitra Dutta
Quantum-dot (QD) based nanosensors are frequently used by researchers to detect small molecules, ions and different biomolecules. In this article, we present a sensor complex/system comprised of deoxyribonucleic acid (DNA) aptamer, gold nanoparticle and semiconductor QD, attached to a graphene oxide (GO) flake for detection of potassium. As reported herein, it is demonstrated that QD-aptamer-quencher nanosensor functions even when tethered to GO, opening the way to future applications where sensing can be accomplished simultaneously with other previously demonstrated applications of GO such as serving as a nanocarrier for drug delivery...
August 11, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28718000/phenological-model-of-bird-cherry-padus-racemosa-with-data-assimilation
#9
Andis Kalvāns, Tija Sīle, Gunta Kalvāne
The accuracy of the operational models can be improved by using observational data to shift the model state in a process called data assimilation. Here, a data assimilation approach using the temperature similarity to control the extent of extrapolation of point-like phenological observations is explored. A degree-day model is used to describe the spring phenology of the bird cherry Padus racemosa in the Baltic region in 2014. The model results are compared to phenological observations that are expressed on a continuous scale based on the BBCH code...
July 17, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28713632/radiographic-assessment-of-the-presigmoid-retrolabyrinthine-approach
#10
Andrew K Wong, Melissa M Stamates, Anita P Bhansali, Michael Shinners, Ricky H Wong
BACKGROUND: Lesions of the petroclival fissure are difficult to access surgically. Both retrosigmoid and presigmoid retrolabyrinthine approaches have been described to successfully treat these complex tumors. The retrosigmoid approach offers quick and familiar access, whereas the presigmoid retrolabyrinthine approach reduces the operative distance and the need for cerebellar retraction. The presigmoid retrolabyrinthine approach, however, is constrained by anatomical limits that can be subject to patient variation...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28713259/transcallosal-inhibition-during-motor-imagery-analysis-of-a-neural-mass-model
#11
Anna L Mangia, Mauro Ursino, Maurizio Lannocca, Angelo Cappello
The EEG rhythmic activities of the somato-sensory cortex reveal event-related desynchronization (ERD) or event-related synchronization (ERS) in beta band (14-30 Hz) as subjects perform certain tasks or react to specific stimuli. Data reported for imagination of movement support the hypothesis that activation of one sensorimotor area (SMA) can be accompanied by deactivation of the other. In order to improve our understanding of beta ERD/ERS generation, two neural mass models (NMM) of a cortical column taken from Wendling et al...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28712284/mn-ii-oxidation-by-the-multicopper-oxidase-complex-mnx-a-binuclear-activation-mechanism
#12
Alexandra V Soldatova, Lizhi Tao, Christine A Romano, Troy A Stich, William H Casey, R David Britt, Bradley M Tebo, Thomas G Spiro
The bacterial protein complex Mnx contains a multicopper oxidase (MCO) MnxG that, unusually, catalyzes the two-electron oxidation of Mn(II) to MnO2 biomineral, via a Mn(III) intermediate. Although Mn(III)/Mn(II) and Mn(IV)/Mn(III) reduction potentials are expected to be high, we find a low reduction potential, 0.38V (pH 7.8), for the MnxG type 1 Cu(2+), the electron acceptor. Indeed the type 1 Cu(2+) is not reduced by Mn(II) in the absence of molecular oxygen, indicating that substrate oxidation requires an activation step...
July 17, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28711684/folding-of-the-silver-aptamer-in-a-dnazyme-probed-by-2-aminopurine-fluorescence
#13
Runjhun Saran, Lu Yao, Peter Hoang, Juewen Liu
The RNA-cleaving Ag10c DNAzyme was recently isolated via in vitro selection and it can bind two Ag(+) ions for activity. The Ag10c contains a well-defined Ag(+) binding aptamer as indicated by DMS footprinting. Since aptamer binding is often accompanied with conformational changes, we herein used 2-aminopurine (2AP) to probe its folding in the presence of Ag(+). The Ag10c was respectively labeled with 2AP at three different positions, both in the substrate strand and in the enzyme strand. Ag(+)-induced folding was observed at the substrate cleavage junction and the A9 position of the enzyme strand, consistent with aptamer binding...
July 12, 2017: Biochimie
https://www.readbyqxmd.com/read/28711481/simultaneous-integrated-boost-sib-for-treatment-of-gynecologic-carcinoma-intensity-modulated-radiation-therapy-imrt-vs-volumetric-modulated-arc-therapy-vmat-radiotherapy
#14
Irina Vergalasova, Kim Light, Junzo Chino, Oana Craciunescu
The aim of this study was to quantitatively compare dosimetric criteria between intensity-modulated radiation therapy (IMRT) and volumetric-modulated arc therapy (VMAT) plans for patients undergoing radiation treatment of gynecologic carcinoma with a simultaneous integrated boost (SIB) technique. IMRT and VMAT plans were retrospectively analyzed for 20 patients. The elective volume was planned to receive 45 Gy in 25 fractions of 1.8 Gy, with the integrated boost volume (involved nodes) receiving 55 Gy simultaneously...
July 12, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28706618/isolated-ileal-perforation-in-infancy-a-lethal-initial-presentation-of-hirschsprung-s-disease
#15
Fadi Iskandarani, Chawki Hammoud, Sarah Srour, Gloria Pelizzo, Ghassan Nakib, Valeria Calcaterra, Amir Khanafer
Arare case of ileal perforation, as a fatal initial presentation of total colonic aganglionosis (TCA) in infancy is reported. A 10-week-old boy, was brought to the emergency department with symptoms of complicated intestinal obstruction. He looked ill, was lethargic, markedly dehydrated and had a severely distended abdomen. An abdominal X-ray revealed multiple air fluid levels seen in a distended small intestine. During exploratory laparotomy the ileum was massively dilated with distal segment perforation. Ileal perforation repair was performed...
June 26, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/28705815/sigmoid-sinus-diverticulum-dehiscence-and-venous-sinus-stenosis-potential-causes-of-pulsatile-tinnitus-in-patients-with-idiopathic-intracranial-hypertension
#16
J A Lansley, W Tucker, M R Eriksen, P Riordan-Eva, S E J Connor
BACKGROUND AND PURPOSE: Pulsatile tinnitus is experienced by most patients with idiopathic intracranial hypertension. The pathophysiology remains uncertain; however, transverse sinus stenosis and sigmoid sinus diverticulum/dehiscence have been proposed as potential etiologies. We aimed to determine whether the prevalence of transverse sinus stenosis and sigmoid sinus diverticulum/dehiscence was increased in patients with idiopathic intracranial hypertension and pulsatile tinnitus relative to those without pulsatile tinnitus and a control group...
July 13, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28705174/extensive-colorectal-lymphomatous-polyposis-complicated-by-acute-intestinal-obstruction-a-case-report
#17
Jaques Waisberg, Amanda do Val Anderi, Pedro Augusto Soffner Cardoso, José Henrique Miranda Borducchi, Demetrius Eduardo Germini, Maria Isete Fares Franco, Cidia Vasconcellos
BACKGROUND: Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of B-cell non-Hodgkin's lymphoma. We report an unusual case of a patient with multiple lymphomatous polyposis with extensive colorectal involvement and acute intestinal obstruction, an atypical complication of this rare disease...
July 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28702886/comparison-of-transvaginal-sonography-and-computed-tomography-colonography-with-contrast-media-and-urographic-phase-for-diagnosing-deep-infiltrating-endometriosis-of-the-posterior-compartment-of-the-pelvis-a-pilot-study
#18
Letizia Zannoni, Simona Del Forno, Francesca Coppola, Dimitris Papadopoulos, Domenico Valerio, Rita Golfieri, Giacomo Caprara, Roberto Paradisi, Renato Seracchioli
PURPOSE: To compare the diagnostic accuracy of transvaginal sonography (TVS) and computed tomography-colonography with contrast media and urographic phase (CTCU) in the preoperative detection of deep infiltrating endometriosis (DIE). MATERIALS AND METHODS: Forty-seven patients with clinical suspicion of DIE underwent preoperative TVS and CTCU. Imaging data were compared with histopathologic analysis. Sensitivity, specificity, positive and negative predictive values and test accuracies of the two modalities were calculated...
July 12, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/28702115/staged-arterial-and-venous-embolizations-in-treatment-of-type-iv-intraosseous-dural-arteriovenous-fistula
#19
Aleksandra V Betcher, Andrew W Schnure, Paul H Janda, Rajneesh Agrawal, Amandeep Dhillon
OBJECTIVE: This is a case report of an adult male with complex type IV intraosseous DAVF causing severe venous hypertension and bony destruction, presenting with severe hemotympanum, and a novel way of staged arterial and venous embolizations to treat the emergent symptoms. METHODS: First and second stages were direct selective arterial embolizations using Onyx liquid agent. Goal was to reduce flow into the fistula by embolizing the feeder branch and distal penetration of the nidus with Onyx...
June 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/28701951/pharmacokinetic-pharmacodynamic-modeling-of-tulathromycin-against-pasteurella-multocida-in-a-porcine-tissue-cage-model
#20
Qiaoyi Zhou, Guijun Zhang, Qin Wang, Wenguang Liu, Yan Huang, Pengling Yu, Yanqin Li, Huanzhong Ding, Binghu Fang
Tulathromycin, a macrolide antibiotic, is used for the treatment of respiratory disease in cattle and swine. The aim of our study was to investigate the in vitro and ex vivo activities of tulathromycin in serum, (non-inflamed) transudate, and (inflamed) exudate against Pasteurella multocida in piglets. The pharmacokinetics properties of tulathromycin were studied for serum, transudate, and exudate using a tissue cage model. In vitro antibiotic susceptibility of P. multocida and dynamic time-kill curve experiments over eight tulathromycin concentrations were determined...
2017: Frontiers in Pharmacology
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