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https://www.readbyqxmd.com/read/29457634/-cooperative-collapse-of-the-denatured-state-revealed-through-clausius-clapeyron-analysis-of-protein-denaturation-phase-diagrams
#1
Alexander Tischer, Venkata R Machha, Jörg Rösgen, Matthew Auton
Protein phase diagrams have a unique potential to identify the presence of additional thermodynamic states even when non-2-state character is not readily apparent from the experimental observables used to follow protein unfolding transitions. Two-state analysis of the von Willebrand factor A3 domain has previously revealed a discrepancy in the calorimetric enthalpy obtained from thermal unfolding transitions as compared with Gibbs-Helmholtz analysis of free energies obtained from the Linear Extrapolation Method (Tischer and Auton, Prot Sci 2013; 22(9):1147-60)...
February 19, 2018: Biopolymers
https://www.readbyqxmd.com/read/29455175/when-a-polyp-is-not-a-polyp-incidental-finding-of-a-sigmoid-schwannoma-at-first-colonoscopic-screening
#2
Alexandra Leonard, Lezah P McCarthy, Danielle M Pastor
Schwannomas, peripheral nerve sheath tumours arising from Schwann cells, are often associated with inherited disorders such as neurofibromatosis. Gastrointestinal schwannomas, while rare, have been reported in those without personal or family history of neurofibromatosis. Diagnoses of these lesions, however, typically follow evaluations prompted by symptomatic presentations associated with abdominal pain, rectal bleeding, change in bowel habits or positive results on faecal occult blood tests performed for colorectal cancer screening...
February 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29454951/the-role-of-sucrose-concentration-in-self-assembly-kinetics-of-high-methoxyl-pectin
#3
Daniela Giacomazza, Donatella Bulone, Pier Luigi San Biagio, Rosamaria Marino, Romano Lapasin
Several natural and synthetic polysaccharides are able to form, under appropriate conditions, supramolecular structures, typically physical hydrogels, and, together with their biocompatibility, this explains their wide use in food, pharmaceutical and biomedical sectors. In the case of high methoxyl pectins (HMP) the gel formation is promoted by the presence of cosolutes (sugars or polyols) and low pH. The present investigation mainly regards the structuring kinetics of aqueous HMP solutions at acid pH (3.1) with the same pectin concentration (0...
February 15, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29454229/pancreatic-cancer-presenting-as-colonic-disease-a-rare-case-report
#4
Sara Tavares Nogueira, Bruno Lima Pinto, Eduardo Faria Silva, Hermano Anjos Garcia, Francisco Carneiro
INTRODUCTION: Pancreatic cancer is the fourth major cause of cancer-related deaths. About 50% of the patients are diagnosed with advanced disease. Metastatic disease to the colon is a very rare entity with only 5 cases described in english literature. CASE PRESENTATION: Male, 60 years-old, presents to a surgical consult with the diagnosis of an adenocarcinoma of the sigmoid colon. The physical exam revealed a periumbilical nodule with suspicious features. The staging CT-scan showed a mass in the tail of the pancreas involving the spleen and left kidney, thickening of the sigmoid colon, multiple mesenteric masses and trabecular changes in the ischium, suggesting metastatic disease...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29453737/two-stage-hepatectomy-aiming-for-the-development-of-intrahepatic-venous-collaterals-for-multiple-colorectal-liver-metastases
#5
Harufumi Maki, Shouichi Satou, Kentaro Nakajima, Atsuki Nagao, Kazuteru Watanabe, Hitoshi Satodate, Satoshi Nara, Kaoru Furushima, Yasushi Harihara
BACKGROUND: Aggressive hepatectomy with venous resection has a higher risk of postoperative liver failure (POLF) than hepatectomy without venous reconstruction; however, venous reconstruction is technically demanding. We performed a novel two-stage hepatectomy (TSH) without venous reconstruction in a patient with bilobar multiple colorectal liver metastases located near the caval confluence, waiting for the development of intrahepatic venous collaterals between procedures. CASE PRESENTATION: A 60-year-old man was referred to our hospital with sigmoid colon cancer accompanied by intraabdominal abscess and two synchronous liver metastases...
February 16, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29452435/dynamic-lumen-obstructing-angulation-in-advanced-sigmoid-type-achalasia-successfully-treated-by-additional-proximal-curve-myotomy
#6
Stefan Seewald, Tiing Leong Ang, Michael Patak, Karl Yu Kim Teng, Haruhiro Inoue
No abstract text is available yet for this article.
February 16, 2018: Endoscopy
https://www.readbyqxmd.com/read/29452077/clinical-outcomes-and-factors-related-with-colonic-perforations-in-patients-receiving-self-expandable-metal-stent-insertion-for-malignant-colorectal-obstruction
#7
Yoo Jin Lee, Jin Young Yoon, Jae Jun Park, Soo Jung Park, Jie-Hyun Kim, Young Hoon Youn, Tae Il Kim, Hyojin Park, Won Ho Kim, Jae Hee Cheon
BACKGROUND AND AIMS: Although colonic perforation is a dreadful adverse event associated with stent placement, data on this topic are sparse. We aimed to investigate the clinical outcomes of colonic perforation and factors related with its occurrence in patients who receiving self-expanding metal stents (SEMSs) for malignant colorectal obstruction. METHODS: We retrospectively reviewed the data of 474 patients with malignant colorectal obstruction who received endoscopic SEMS insertion from April 2004 to May 2011 in the Severance and Gangnam Severance Hospital...
February 13, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29451620/application-of-a-pharmacokinetics-pharmacodynamics-approach-to-the-free-propofol-plasma-levels-during-coronary-artery-bypass-grafting-surgery-with-hypothermic-cardiopulmonary-bypass
#8
Carlos R Silva-Filho, Ricardo Antonio G Barbosa, Carlindo V Silva-Jr, Luiz M S Malbouisson, Maria José C Carmona, Silvia Regina C Jorge-Santos
OBJECTIVES: The objective of this study was to apply a pharmacokinetics-pharmacodynamics approach to investigate the free propofol plasma levels in patients undergoing coronary artery bypass grafting under hypothermic conditions compared with the off-pump procedure. METHODS: Nineteen patients scheduled for on-pump coronary artery bypass grafting under hypothermic conditions (n=10) or the equivalent off-pump surgery (n=9) were anesthetized with sufentanil and propofol target-controlled infusion (2 μg/mL) during surgery...
2018: Clinics
https://www.readbyqxmd.com/read/29449663/quantitative-evaluation-of-pain-during-electrocutaneous-stimulation-using-a-log-linearized-peripheral-arterial-viscoelastic-model
#9
Hiroki Matsubara, Hiroki Hirano, Harutoyo Hirano, Zu Soh, Ryuji Nakamura, Noboru Saeki, Masashi Kawamoto, Masao Yoshizumi, Atsuo Yoshino, Takafumi Sasaoka, Shigeto Yamawaki, Toshio Tsuji
In clinical practice, subjective pain evaluations, e.g., the visual analogue scale and the numeric rating scale, are generally employed, but these are limited in terms of their ability to detect inaccurate reports, and are unsuitable for use in anesthetized patients or those with dementia. We focused on the peripheral sympathetic nerve activity that responds to pain, and propose a method for evaluating pain sensation, including intensity, sharpness, and dullness, using the arterial stiffness index. In the experiment, electrocardiogram, blood pressure, and photoplethysmograms were obtained, and an arterial viscoelastic model was applied to estimate arterial stiffness...
February 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29447946/bladder-re-augmentation-in-classic-bladder-exstrophy-risk-factors-and-prevention
#10
Karl Benz, John Jayman, Karen Doersch, Mahir Maruf, Timothy Baumgartner, Matthew Kasprenski, John P Gearhart
OBJECTIVE: To characterize the causes of re-augmentation in patients with classic bladder exstrophy. METHODS: A prospectively-maintained institutional database of 1327 exstrophy-epispadias complex patients was reviewed for CBE patients who have undergone more than one AC procedure. Data regarding bladder capacities, complications following AC, and reasons for re-augmentation were evaluated. RESULTS: A total of 166 CBE patients underwent AC...
February 12, 2018: Urology
https://www.readbyqxmd.com/read/29447856/laparoscopic-sacrohysteropexy-in-a-12-weeks-pregnant-woman
#11
Berna Haliloglu Peker, Erdin Ilter, Hakan Peker, Aygen Celik, Ali Gursoy, Onur Gunaldi
STUDY OBJECTIVE: To demonstrate laparoscopic sacrohysteropexy for a case of uterine prolapse in a 12 weeks and 3 days pregnant woman. To our knowledge, this is the first case of laparoscopic sacrohysteropexy performed at 12th weeks of gestation to be reported in literature. DESIGN: A step-by-step explanation of the surgical procedure (Canadian Task Force classification III) SETTING: Uterine prolapse is very rare condition manifesting in an estimated 10000 to 15000 pregnancies (1)...
February 12, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29447222/kinetics-of-pten-mediated-pi-3-4-5-p3-hydrolysis-on-solid-supported-membranes
#12
Chun Liu, Sanghamitra Deb, Vinicius S Ferreira, Eric Xu, Tobias Baumgart
Phosphatidylinositides play important roles in cellular signaling and migration. Phosphatidylinositol-3,4,5-trisphosphate (PI(3,4,5)P3) is an important phosphatidylinositide because it acts as a secondary messenger to trigger cell movement and proliferation. A high level of PI(3,4,5)P3 at the plasma membrane is known to contribute to tumorigenesis. One key enzyme that regulates PI(3,4,5)P3 levels at the plasma membrane is phosphatase and tensin homologue deleted on chromosome 10 (PTEN), which dephosphorylates PI(3,4,5)P3 through hydrolysis to form phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2)...
2018: PloS One
https://www.readbyqxmd.com/read/29447028/elastase-as-a-potential-biomarker-for-radiation-induced-gut-wall-injury-of-the-distal-bowel-in-an-experimental-mouse-model
#13
Fei Sjöberg, Dilip Kumar Malipatlolla, Piyush Patel, Ulrica Wilderäng, Marie Kalm, Gunnar Steineck, Cecilia Bull
BACKGROUND AND PURPOSE: Traditionally, elastase has been used to study exocrine activity of the pancreas in patients with chronic pancreatitis and cystic fibrosis, and calprotectin as a marker for gut-wall inflammation in patients with inflammatory bowel disease. The aim of the study was to find out whether elastase and calprotectin could be used as inflammatory markers for radiation-induced gut wall injury of the distal bowel. MATERIAL AND METHODS: Adult male mice were exposed to two, three, or four fractions of 6 Gy or 8 Gy irradiation to the sigmoid and rectum of the large bowel, using a linear accelerator...
February 15, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29439825/successful-endoscopic-extraction-of-dental-prosthesis-impacted-in-a-sigmoid-diverticulum
#14
G Blanco-Velasco, O V Hernández-Mondragón, M L Altamirano-Castañeda, J M Blancas-Valencia
No abstract text is available yet for this article.
February 10, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29439318/the-effect-of-three-different-surgical-techniques-for-colon-anastomosis-on-regional-postoperative-microperfusion-laser-doppler-flowmetry-study-in-pigs
#15
Milan Kaska, Slavomir Blazej, Zdenek Turek, Ales Ryska, Boris Jegorov, Vera Radochova, Jan Bezouska, Jiri Paral
BACKGROUND: The optimal surgical approach to reconnecting bowel ends safely after resection is of great importance. OBJECTIVES: This project is focused on assessment of the perianastomotic microcirculation quality in the short postoperative period when using three different anastomosis techniques in experimental animal. METHODS: The experimental study involved 27 young female domestic pigs divided into three subgroups of 9 animals according to each surgical method of anastomosis construction in the sigmoid colon region: by manual suture, by stapler, or by gluing...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29438813/temporal-variations-and-spatial-distributions-of-heavy-metals-in-a-wastewater-irrigated-soil-eggplant-system-and-associated-influencing-factors
#16
Shiwei Ai, Bailin Liu, Ying Yang, Jian Ding, Wenzhi Yang, Xiaojuan Bai, Sajid Naeem, Yingmei Zhang
Heavy metal pollution in farmlands is highly concerned as crops' easy-uptake of heavy metal can ultimately affect consumers. In order to offer suggestions on cultivating safe quality vegetable, specifically eggplant which is widely consumed for its nutritional value and antioxidant activity, a field study was undertaken to investigate the temporal variations and spatial distributions of heavy metals in a wastewater-irrigated soil-eggplant system. In the present study, eggplants were planted in the farmlands of Weichuan village (WC) (relatively unpolluted field), Liangzhuang village (LZ) (moderately polluted field) and Minqin village (MQ) (seriously polluted field) to elucidate their temporal uptake processes of heavy metals described by the sigmoid model...
February 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29433380/acute-abdominal-pain-due-to-internal-herniation-of-the-sigmoid-colon-fallopian-tube-and-left-ovary-a-rare-presentation-of-allen-masters-syndrome
#17
C H Mazzetti, N Hock, S Taylor, J Lemaitre, K Crener, E Lebrun
In 1955, Allen and Masters describe a painful syndrome which associates traumatic delivery to laceration found on the posterior leaf of the broad ligament. Herniation through this defect is a rare entity, accounted for about 4-7% of all internal hernias. Normally, it involves the small bowel. The authors present the case of a multiparous woman admitted at emergency for constipation and abdominal pain. The CT scan showed an extremely rare case of internal hernia of the sigmoid colon, fallopian tube and left ovary through a large defect of the broad ligament...
February 12, 2018: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/29431849/medical-treatment-in-the-management-of-deep-endometriosis-infiltrating-the-proximal-rectum-and-sigmoid-colon-a-comprehensive-literature-review
#18
Paolo Vercellini, Laura Buggio, Alessandra Borghi, Ermelinda Monti, Umberto Gattei, Maria Pina Frattaruolo
A comprehensive literature review was performed to evaluate the effect of various hormonal therapies, in terms of variations of intestinal and pain complaints and of patient satisfaction with treatment, in women with symptomatic, non-severely sub-occlusive endometriosis infiltrating the proximal rectum and sigmoid colon. A MEDLINE search through PubMed from 2000 to 2018 was conducted to identify all original English language articles published on medical treatment for colorectal endometriosis. Additional reports were identified by systematically reviewing reference lists and using the "similar articles" function in PubMed...
February 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29429688/a-simple-approach-for-the-sonochemical-loading-of-au-ag-and-pd-nanoparticle-on-functionalized-mwcnt-and-subsequent-dispersion-studies-for-removal-of-organic-dyes-artificial-neural-network-and-response-surface-methodology-studies
#19
Mitra Moghaddari, Fakhri Yousefi, Mehrorang Ghaedi, Kheibar Dashtian
In this study, the artificial neural network (ANN) and response surface methodology (RSM) based on central composite design (CCD) were applied for modeling and optimization of the simultaneous ultrasound-assisted removal of quinoline yellow (QY) and eosin B (EB). The MWCNT-NH2 and its composites were prepared by sonochemistry method and characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy dispersive spectroscopy (EDS) analysis's. Initial dyes concentrations, adsorbent mass, sonication time and pH contribution on QY and EB removal percentage were investigated by CCD and replication of experiments at conditions suggested by model has results which statistically are close to experimented data...
April 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29428950/severity-of-diverticulitis-does-not-influence-abdominal-complaints-during-long-term-follow-up
#20
Max Ditzel, Sandra Vennix, Anand G Menon, Paul C M Verbeek, Willem A Bemelman, Johan F Lange
BACKGROUND: Diverticulitis can lead to localized or generalized peritonitis and consequently induce abdominal adhesion formation. If adhesions would lead to abdominal complaints, it might be expected that these would be more prominent after operation for perforated diverticulitis with peritonitis than after elective sigmoid resection. AIMS: The primary outcome of the study was the incidence of abdominal complaints in the long-term after acute and elective surgery for diverticulitis...
February 9, 2018: Digestive Surgery
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