Chi Zhang, Xiongxiong Cai, Mei Li, Jing Peng, Jin Mei, Fangfang Wang, Rui Zhang, Yingjie Zhou, Shuyu Fang, Dongdong Xia, Jiyuan Zhao
In vertebroplasty and kyphoplasty, bioinert poly(methyl methacrylate) (PMMA) bone cement is a conventional filler employed for quick stabilization of osteoporotic vertebral compression fractures (OVCFs). However, because of the poor osteointegration, excessive stiffness, and high curing temperature of PMMA, the implant loosens, the adjacent vertebrae refracture, and thermal necrosis of the surrounding tissue occurs frequently. This investigation addressed these issues by incorporating the small intestinal submucosa (SIS) into PMMA (SIS-PMMA)...
March 13, 2024: ACS Biomaterials Science & Engineering