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https://www.readbyqxmd.com/read/29116357/injectable-biomechanically-robust-biodegradable-and-osseointegrative-bone-cement-for-percutaneous-kyphoplasty-and-vertebroplasty
#1
Huiling Liu, Bin Liu, Chunxia Gao, Bin Meng, Huilin Yang, Haiyang Yu, Lei Yang
PURPOSE: Poly(methyl methacrylate) (PMMA) cement is widely used for percutaneous kyphoplasty and vertebroplasty (PKP and PVP) but possesses formidable shortcomings due to non-degradability. Here, a biodegradable replacement is developed. METHODS: Calcium phosphate cement (CPC) was redesigned by incorporating starch and BaSO4 (new cement named as CPB). The biomechanical, biocompatibility, osseointegrative and handling properties of CPB were systematically evaluated in vitro and in vivo by the models of osteoporotic sheep vertebra, rat subcutaneous implantation and rat femoral defect...
November 7, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29107056/strontium-modified-premixed-calcium-phosphate-cements-for-the-therapy-of-osteoporotic-bone-defects
#2
A Lode, C Heiss, G Knapp, J Thomas, B Nies, M Gelinsky, M Schumacher
In this study a premixed strontium-containing calcium phosphate bone cement for the application in osteoporotic bone defects has been developed and characterised regarding its material and in vitro properties as well as minimally invasive applicability in balloon kyphoplasty. Strontium was introduced into the cement by substitution of one precursor component, CaCO3, with its strontium analogue, SrCO3. Using a biocompatible oil phase as carrier liquid, a cement paste that only set upon contact with aqueous environment was obtained...
October 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29100666/use-of-corticosteroids-is-not-associated-with-repeated-vertebroplasty-or-kyphoplasty-within-one-year-after-the-surgery-in-patient-older-than-50-years
#3
Feng-Chen Kao, Yao-Chun Hsu, Chin-Hsien Wu, Chang-Bi Wang, Yuan-Kun Tu, Pao-Hsin Liu
OBJECTIVE: The aim of this study was to investigate whether corticosteroid use increases the incidence of repeated PVP or kyphoplasty patients older than 50 years. METHODS: This study enrolled the data of 2,753 eligible patients from the Taiwan National Health Insurance Research Database who were exposed to systemic corticosteroids for at least 3 months during the first year preceding the first PVP or kyphoplasty. These steroid users were matched 1:1 in age, sex, and the index date of surgery with non-user controls during the enrollment period...
October 31, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29095327/cerebral-venous-sinus-thrombosis-due-to-low-molecular-weight-heparin-induced-thrombocytopenia
#4
Ezequiel Gleichgerrcht, Ming Y Lim, Tanya N Turan
INTRODUCTION: Heparin-induced thrombocytopenia (HIT) is an immune-mediated complication of heparin exposure. A limited number of studies have reported cerebral venous sinus thrombosis (CVST) as the presenting thrombotic event induced by HIT, only one of which occurred with exposure to low-molecular-weight heparin (LMWH), with death as outcome. Here, we present a unique case of LMWH-induced HIT leading to CVST but resulting in good clinical outcome. CASE REPORT: A 52-year-old woman received subcutaneous LMWH for deep vein thrombosis prophylaxis while in rehabilitation following kyphoplasty for spinal fracture related to recent trauma...
November 2017: Neurologist
https://www.readbyqxmd.com/read/29063215/were-vcf-patients-at-higher-risk-of-mortality-following-the-2009-publication-of-the-vertebroplasty-sham-trials
#5
K L Ong, D P Beall, M Frohbergh, E Lau, J A Hirsch
The 5-year period following 2009 saw a steep reduction in vertebral augmentation volume and was associated with elevated mortality risk in vertebral compression fracture (VCF) patients. The risk of mortality following a VCF diagnosis was 85.1% at 10 years and was found to be lower for balloon kyphoplasty (BKP) and vertebroplasty (VP) patients. INTRODUCTION: BKP and VP are associated with lower mortality risks than non-surgical management (NSM) of VCF. VP versus sham trials published in 2009 sparked controversy over its effectiveness, leading to diminished referral volumes...
October 24, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/29057346/corpectomy-and-expandable-cage-replacement-versus-third-generation-percutaneous-augmentation-system-in-case-of-vertebra-plana-rationale-and-recommendations
#6
Daniele Vanni, Andrea Pantalone, Vincenzo Magliani, Vincenzo Salini, Pedro Berjano
BACKGROUND: To evaluate the role of third generation percutaneous vertebral augmentation systems (Spine Jack(®)) as alternative to the corpectomies and expandable cages replacement (X-Core(®) Adjustable VBR System) in the treatment of vertebra plana (VP) as complication of the osteoporosis vertebral fracture (OVF). METHODS: Spine Jack(®) is a new device for mechanical kyphoplasty (MK). It is a titanium implant designed to restore the height of the vertebral body in OVF, primary or secondary bone tumors, or traumatic fractures...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29057344/utilization-of-vertebroplasty-and-kyphoplasty-procedures-throughout-the-united-states-over-a-recent-decade-an-analysis-of-the-nationwide-inpatient-sample
#7
Joseph L Laratta, Jamal N Shillingford, Joseph M Lombardi, John D Mueller, Hemant Reddy, Comron Saifi, Charla R Fischer, Steven C Ludwig, Lawrence G Lenke, Ronald A Lehman
BACKGROUND: Given the increasing societal focus on health care utilization and value-based care, it is essential to understand the demographic and economic data surrounding percutaneous vertebral augmentation procedures performed in the United States. Double-blinded prospective randomized controlled trials have shown no benefit to the use of vertebroplasty over a sham procedure in the treatment of vertebral fractures. Contrastingly, kyphoplasty may be beneficial when appropriately indicated...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29055740/percutaneous-balloon-kyphoplasty-for-treatment-of-very-severe-osteoporotic-vertebral-compression-fractures-a-case-controlled-study
#8
Jin Kyu Lee, Hae-Won Jeong, Il-Han Joo, Young-Il Ko, Chang-Nam Kang
BACKGROUND CONTEXT: There exists controversy regarding percutaneous balloon kyphoplasty (PBK) in patients with very severe osteoporotic vertebral compression fracture (vsOVCF). PURPOSE: The study was conducted to investigate the clinical and radiological outcomes of PBK for the treatment of vsOVCF compared with those of non-vsOVCF. STUDY DESIGN/SETTING: Retrospective, case controlled. PATIENT SAMPLE: 167 consecutive patients (210 vertebral bodies) who underwent PBK for OVCF between March 2010 and January 2015 were assessed...
October 18, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29031993/the-gdf5-mutant-bb-1-enhances-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#9
Francesca Gunnella, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann, Matthias Bungartz
BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (BMPs; e.g., GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and support complete bone regeneration. The biologically optimized GDF5 mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose BB-1 in a sheep lumbar osteopenia model...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29030463/efficacy-and-safety-of-the-target-puncture-technique-for-treatment-of-osteoporotic-vertebral-compression-fractures-with-intravertebral-clefts
#10
Weibo Yu, De Liang, Xiaobing Jiang, Zhensong Yao, Ting Qiu, Linqiang Ye
OBJECTIVE: To compare the efficacy and safety of our target puncture technique with the traditional technique during percutaneous kyphoplasty (PKP) for osteoporotic vertebral compression fractures (OVCFs) with intravertebral clefts (IVCs). METHODS: 104 patients treated with PKP for single OVCFs with IVCs were retrospectively reviewed. All patients were divided into three groups: cleft filling by the traditional technique (Group A, n=18); interdigitated filling (Group B, n=50); and overfilling by the target technique (Group C, n=36)...
November 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28988630/differences-in-short-term-clinical-and-radiological-outcomes-depending-on-timing-of-balloon-kyphoplasty-for-painful-osteoporotic-vertebral-fracture
#11
Shinji Takahashi, Masatoshi Hoshino, Hidetomi Terai, Hiromitsu Toyoda, Akinobu Suzuki, Koji Tamai, Kyoei Watanabe, Tadao Tsujio, Hiroyuki Yasuda, Hiroshi Kono, Ryuichi Sasaoka, Sho Dohzono, Kazunori Hayashi, Shoichiro Ohyama, Yusuke Hori, Hiroaki Nakamura
BACKGROUND: Balloon kyphoplasty or vertebroplasty is widely performed as a surgical intervention for osteoporotic vertebral fracture (OVF) and the effects have been investigated in many previous studies. However, the influence of the timing of the procedure on patient outcomes has not been studied formally. The purpose of this study was to investigate differences in the surgical outcomes of OVFs according to the timing of balloon kyphoplasty. METHODS: This was a multicenter cohort study...
October 4, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28979679/dynamic-characteristics-of-osteoporotic-lumbar-spine-under-vertical-vibration-after-cement-augmentation
#12
Xinlin Su, Hao Shen, Weidong Shi, Huilin Yang, Feng Lv, Jun Lin
Being beneficial in restoring stability and stiffness of osteoporotic vertebraes, cement augmentation techniques including vertebroplasty (VP) and kyphoplasty (KP) have been demonstrated to be effective for the treatment of patients with osteoporotic vertebral compressive fractures (OVCFs). However, it is unclear the influence of cement augmentation on the dynamics of pathologic and adjacent vertebraes under vibration condition. In this study, we developed a three-dimensional (3D) finite-element (FE) model of the spinal T12-Pelvis segment by using CT scan data of lumbar spine of an adult woman with no physical abnormalities...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28969223/evaluation-of-percutaneous-vertebroplasty-for-management-of-symptomatic-osteoporotic-compression-fracture
#13
Arnab Karmakar, Suchi Acharya, Dibyendu Biswas, Arkaprabha Sau
INTRODUCTION: Osteoporotic vertebral compression fractures are a leading cause of disability and associated morbidities among Indian population. Worldwide, approximately 20% of elderly population above 70 years and 16% of postmenopausal women are suffering from it. Vertebral compression fractures should be aggressively treated with minimally invasive techniques such as Percutaneous Vertebroplasty (PVP) or Percutaneous Kyphoplasty (PKP) to minimize pain and disability associated with it...
August 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28962909/phase-i-ii-trial-of-combined-kyphoplasty-and-intraoperative-radiotherapy-in-spinal-metastases
#14
Frederic Bludau, Grit Welzel, Tina Reis, Frank Schneider, Elena Sperk, Christian Neumaier, Michael Ehmann, Sven Clausen, Udo Obertacke, Frederik Wenz, Frank A Giordano
BACKGROUND CONTEXT: Spinal metastases occur in 30%-50% of patients with systemic cancer. The primary goals of palliation are pain control and prevention of local recurrence. PURPOSE: This study aimed to test the safety and efficacy of a combined modality approach consisting of kyphoplasty and intraoperative radiotherapy (Kypho-IORT). STUDY DESIGN/SETTING: Kyphoplasty and intraoperative radiotherapy was a prospective, single-center phase I/II trial...
September 28, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28952779/clinical-outcome-and-subsequent-sequelae-of-cement-extravasation-after-percutaneous-kyphoplasty-and-vertebroplasty-a-comparative-review
#15
Hassan Semaan, Tawfik Obri, Mohamad Bazerbashi, Daniel Paull, Xiaochen Liu, Marah Sarrouj, Hossein Elgafy
Background Injection of cement during vertebroplasty and kyphoplasty can leak into surrounding structures and could be symptomatic. Purpose To identify the sites and incidence of cement extravasation after kyphoplasty and vertebroplasty, and to evaluate their impacts on clinical outcomes. Material and Methods A retrospective review of 316 patients treated with kyphoplasty and vertebroplasty; 411 cases were included (223 kyphoplasty and 188 vertebroplasty). Cement extravasation was evaluated postoperatively by computed tomography (CT) scan of the spine...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28937459/percutaneous-kyphoplasty-for-the-treatment-of-osteoporotic-vertebral-fractures-with-intravertebral-fluid-or-air-a-comparative-study
#16
Junjie Niu, Dawei Song, Haifei Zhou, Qian Meng, Bin Meng, Huilin Yang
STUDY DESIGN: A retrospective comparative study. OBJECTIVE: To compare the characteristics of osteoporotic vertebral fractures (OVFs) with intravertebral fluid (IVF) and those with intravertebral air (IVA), and the efficacy of percutaneous balloon kyphoplasty (PKP) in treating OVFs with these 2 different intravertebral components. SUMMARY OF BACKGROUND DATA: Previous studies have focused on the efficacy of percutaneous vertebroplasty (PVP) and PKP in treating OVFs with intravertebral cleft...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28934783/serious-adverse-events-associated-with-readmission-through-one-year-after-vertebral-augmentation-with-either-a-polyetheretherketone-implant-or-balloon-kyphoplasty
#17
Douglas P Beall, Jeffrey D Coe, Mark McIlduff, Daniel Bloch, John Hornberger, Christopher Warner, Sean Tutton
BACKGROUND: The KAST (Kiva Safety and Efficacy) investigation device exempt (IDE) study indicated that the majority of patients responded equally well to vertebral augmentation using either an implant-based approach or balloon kyphoplasty (BK). Additional investigation has suggested that a subset of patients may benefit further by avoiding repeated readmissions due to serious adverse events (SAEs) if they receive one vertebral augmentation approach over another. OBJECTIVES: The primary aim was to assess the effect of 2 different augmentation procedures on readmission rates for SAEs...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28893205/is-additional-balloon-kyphoplasty-safe-and-effective-for-acute-thoracolumbar-burst-fracture
#18
Ping-Jui Tsai, Ming-Kai Hsieh, Kuo-Feng Fan, Lih-Huei Chen, Chia-Wei Yu, Po-Liang Lai, Chi-Chien Niu, Tsung-Ting Tsai, Wen-Jer Chen
BACKGROUND: Burst fracture is a common thoracolumbar injury that is treated using posterior pedicle instrumentation and fusion combined with transpedicular intracorporeal grafting after reduction. In this study, we compared the outcome of these two techniques by using radiologic imaging and functional outcome. METHODS: Sixty-one patients with acute thoracolumbar burst fracture were operated with kyphoplasty (n = 31) or vertebroplasty (n = 30) and retrospectively reviewed in our institution between 2011 and 2014...
September 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28890571/a-novel-position-for-d2-kyphoplasty-swimmer-s-position
#19
Shagun Bhatia Shah, Ajay Kumar Bhargava, Ramandeep Singh Jaggi
No abstract text is available yet for this article.
August 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28866174/modification-of-calcium-phosphate-cement-with-poly-%C3%AE-glutamic-acid-and-its-strontium-salt-for-kyphoplasty-application
#20
Chunxia Gao, Huiling Liu, Zong-Ping Luo, Sajilafu, Huilin Yang, Lei Yang
To meet the requirements of minimally invasive surgical treatments for osteoporotic vertebral compression fracture, various strategies have been proposed to enhance the properties of calcium phosphate cement (CPC). Here, a new strategy was developed by incorporating poly (γ-glutamic acid) (γ-PGA) and its strontium salt into the formulation of alpha tricalcium phosphate (α-TCP)-based CPC. Effects of γ-PGA on the injectability, cohesion, setting times, mechanical compressive strengths and cytocompatibility were systematically studied...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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