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https://www.readbyqxmd.com/read/28642196/gdf5-significantly-augments-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#1
Matthias Bungartz, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Francesca Gunnella, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann
BACKGROUND CONTEXT: Biodegradable calcium phosphate cement (CPC) represents a promising option for the surgical treatment of osteoporotic vertebral fractures. Due to augmented local bone catabolism, however, additional targeted delivery of bone morphogenetic proteins with the CPC may be needed to promote rapid and complete bone regeneration. PURPOSE: In the present study, an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing the bone morphogenetic protein GDF5 was tested in a sheep lumbar osteopenia model...
June 19, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28640112/cement-leakage-in-osteoporotic-vertebral-compression-fractures-with-cortical-defect-using-high-viscosity-bone-cement-during-unilateral-percutaneous-kyphoplasty-surgery
#2
Tie Liu, Zhe Li, Qingjun Su, Yong Hai
The purpose of this study was to investigate cement leakage (CL) in osteoporotic vertebral compression fractures (OVCFs) with cortical defect using high-viscosity bone cement during unilateral percutaneous kyphoplasty (PKP) surgery.This study included a series of 77 patients (23 males, 54 females) with single level osteoporotic vertebral body fracture (OVCF) who underwent unilateral PKP in our hospital. Preoperative x-ray, computed tomography (CT) scan, and 3-dimensional reconstructions were studied. During the PKP procedure, needle was carefully put to avoid too near to the cortical defect according to CT image...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28640091/comparison-of-radiofrequency-kyphoplasty-rfk-and-balloon-kyphoplasty-bkp-in-the-treatment-of-vertebral-compression-fractures-a-meta-analysis
#3
Lei Feng, Jin-Ming Shen, Chun Feng, Jie Chen, Yu Wu
BACKGROUND: Balloon kyphoplasty (BKP) is a widely adopted minimally invasive treatment for vertebral compression fractures (VCFs), but leakage of cement is a main complication of BKP. A novel vertebral augmentation technique radiofrequency kyphoplasty (RFK) with high viscosity cement was developed in 2009. Here, we aim to evaluate whether RFK can relieve symptoms efficiently and reduce cement leakage. METHODS: A literature search was performed using Pubmed, Embase, and Cochrane CENTRAL until September 30, 2016...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28619686/low-dose-bmp-2-is-sufficient-to-enhance-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#4
Francesca Gunnella, Elke Kunisch, Matthias Bungartz, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Peter Hortschansky, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann
BACKGROUND CONTEXT: Bioresorbable calcium phosphate cement (CPC) may be suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures. However, additional targeted delivery of osteoinductive bone morphogenetic proteins (BMPs) in the CPC may be required to counteract the augmented local bone catabolism and support complete bone regeneration. PURPOSE: The study aimed at testing an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose bone morphogenetic protein BMP-2 in a sheep lumbar osteopenia model...
June 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28607331/a-retrospective-study-of-percutaneous-balloon-kyphoplasty-for-the-treatment-of-symptomatic-schmorl-s-nodes-5-year-results
#5
Sun Zhi-Yong, Zhao Huan, Ling Feng, Lv Nan-Ning, Zhu Xiao-Yu, Pi Bin, Lin Jun, Qian Zhong-Lai, Zhang Zhi-Ming, Yang Hui-Lin
BACKGROUND Despite literature supporting the efficiency of percutaneous balloon kyphoplasty (PKP) in treating osteoporotic and malignant vertebral compression fractures, few reports exist that document its use for treatment of symptomatic Schmorl's nodes (SNs) refractory to conservative treatment. Patients with symptomatic SNs could have pain in the vertebrae similar to an acute vertebral compression fracture. MRI is very helpful in diagnosing symptomatic SNs when x-ray and CT scan are unremarkable. In painful cases, the vertebrae bone marrow around the SNs is hyperintense on T2-weighted subsequence...
June 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28578121/requirements-for-a-stable-long-term-result-in-surgical-reduction-of-vertebral-fragility-fractures
#6
Jesús Crespo-Sanjuán, Francisco Ardura, Rubén Hernández-Ramajo, David C Noriega
BACKGROUND: Osteoporotic vertebral fractures are one of the major health problems in the world. Minimally invasive surgical treatment has a great advantage compared to conservative treatment in treating these fractures as it eliminates the pain and functional disability. The percutaneous intravertebral expandable titanium device (SpineJack®, Vexim SA, France) has benefits compared to other kyphoplasty devices, showing results that are maintained over time and a reduction in complications...
May 31, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28566777/surgical-treatment-of-secondary-fractures-after-percutaneous-vertebroplasty-a-retrospective-study
#7
Jiang-Jun Zhu, Dong-Sheng Zhang, Su-Liang Lou, Yong-Hong Yang
BACKGROUND: Percutaneous vertebroplasty (PVP) and percutaneous kyphoplasty (PKP) are effective procedures for the treatment of vertebral compression fractures (VCFs). However, recent studies have reported that secondary VCFs develop in patients after PVP or PKP treatment. This study aimed to investigate the clinical characteristics and management of secondary fractures after PVP or PKP. MATERIALS AND METHODS: 599 cases who had vertebral compression fracture and underwent PVP or PKP between September 2008 and June 2014 were enrolled, including 121 males and 478 females...
May 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28564667/rhode-island-hospital-s-contribution-to-the-field-of-endoscopic-spine-surgery
#8
Albert E Telfeian, Adetokunbo A Oyelese, Ziya L Gokaslan
The first academic program in endoscopic spine surgery in the United States opened its doors at Rhode Island Hospital in 2012. Published advances in the field since its inception have included treatments for a myriad of pathologies including lumbar and thoracic disc herniations, spondylolisthesis, spine tumors as well as treatments for complications of other spinal procedures including spinal fusion, kyphoplasty, and total disc replacement. In this issue of the Rhode Island Medical Journal we summarize the history of the procedure as well as some of the interesting progress going on in this field in Rhode Island...
June 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28557903/functional-recovery-following-early-kyphoplasty-versus-conservative-management-in-stable-thoracuolumbar-fractures-in-parachute-jumpers-a-randomized-clinical-trial
#9
Mohammad S Masoudi, Ali Haghnegahdar, Fariborz Ghaffarpasand, Ghazal Ilami
STUDY DESIGN: A randomized clinical trial. OBJECTIVE: To compare the functional recovery between early kyphoplasty and conservative care in paratroopers with stable thoracolumbar fractures. SUMMARY OF BACKGROUND DATA: Treatment of traumatic stable thoracolumbar fractures in young individuals is still a debate. Conservative management and kyphoplasty are options of therapy. But enough data are not available for supporting each. METHODS: We included 70 paratroopers with stable thoracolumbar fractures (A1 and A2 classification according to AOSpine thoracolumbar spine injury classification system) presenting <60 days after trauma and hyperintensity in T2-weighted magnetic resonance imaging...
May 26, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28542552/osteoporosis-associated-vertebral-fractures-health-economic-implications
#10
Julian Joestl, Nikolaus Lang, Adam Bukaty, Thomas M Tiefenboeck, Patrick Platzer
INTRODUCTION: Osteoporosis-associated vertebral fractures represent an increasing clinical and public health problem, one with important socioeconomic effects within western countries. The purpose of this study was to analyse demographic, medical, gender and socioeconomic aspects of osteoporotic vertebral fractures of the thoracic or lumbar spine over a period of at least 10-years. MATERIAL AND METHODS: Included for analysis were 694 patients who had suffered a vertebral fracture due to primary or secondary osteoporosis, and who were treated at our Level-I trauma center between 2000 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28535919/precision-iort-image-guided-intraoperative-radiation-therapy-igiort-using-online-treatment-planning-including-tissue-heterogeneity-correction
#11
Frank Schneider, Frederic Bludau, Sven Clausen, Jens Fleckenstein, Udo Obertacke, Frederik Wenz
BACKGROUND: To the present date, IORT has been eye and hand guided without treatment planning and tissue heterogeneity correction. This limits the precision of the application and the precise documentation of the location and the deposited dose in the tissue. Here we present a set-up where we use image guidance by intraoperative cone beam computed tomography (CBCT) for precise online Monte Carlo treatment planning including tissue heterogeneity correction. MATERIALS AND METHODS: An IORT was performed during balloon kyphoplasty using a dedicated Needle Applicator...
May 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28513888/pain-quality-of-life-and-safety-outcomes-of-kyphoplasty-for-vertebral-compression-fractures-report-of-a-task-force-of-the-american-society-for-bone-and-mineral-research
#12
A J Rodriguez, H A Fink, L Mirigian, N Guañabens, R Eastell, K Akesson, D C Bauer, P R Ebeling
The relative efficacy and harms of balloon kyphoplasty (BK) for treating vertebral compression fractures (VCF) are uncertain. We searched multiple electronic databases to March 2016 for randomised and quasi-randomised controlled trials comparing BK with control treatment (non-surgical management [NSM], percutaneous vertebroplasty [PV], KIVA®, vertebral body stenting, or other) in adults with VCF. Outcomes included back pain, back disability, quality of life (QoL), new VCF and adverse events (AE). One reviewer extracted data, a second checked accuracy, and two rated risk of bias (ROB)...
May 17, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28489466/intrathecal-injection-of-gadobutrol-a-tale-of-caution
#13
Corey Reeves, Enrique Galang, Raj Padalia, Nam Tran, Devang Padalia
In the field of interventional pain medicine a radiocontrast agent is commonly used in conjunction with fluoroscopy. Limited work has been published regarding the use of gadolium based contrast agents (GBCA) in the intrathecal space. We report a case of an intrathecal gadobutrol injection resulting in neurotoxic manifestations.A 60-year-old female with a history significant for lumbar post-laminectomy syndrome and intrathecal drug delivery implantation was admitted for lumbar fusion and kyphoplasty. Postoperatively, the patient had escalating pain medication requirements...
June 2017: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/28482645/influence-of-radiofrequency-kyphoplasty-on-pulmonary-function
#14
Simon J Greven, Rahel Bornemann, Philip P Roessler, Yorck Rommelspacher, Sönke P Frey, Tom R Jansen, Kirsten Sander, Dieter C Wirtz, Robert Pflugmacher
BACKGROUND: Vertebral compression fractures (VCF) change the natural spinal alignment and inevitably lead to a decreased quality of life. OBJECTIVE: The aim of the study was to evaluate changes in pulmonary function after VCF were treated by radiofrequency kyphoplasty (RF-TVA). METHODS: Twenty-five patients were treated with RF-TVA and analyzed in 3 subgroups taking into account the spinal location of the VCF. Pain as measured by visual analogue scale (VAS), Oswestry-Disability-Index (ODI), vertebral height, forced expiratory volume in 1 second (FEV1), and peak expiratory flow (PEF) were assessed before, directly after and 30 days after RF-TVA...
April 28, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28454248/primary-bone-mantle-cell-lymphomas-with-multiple-vertebral-compression-fractures-a-case-report
#15
Peng Yang, Jun Lin, Hao Liu, Hao Shen, Hui-Lin Yang
Mantle cell lymphoma (MCL) is a mature B-cell non-Hodgkin lymphoma. Patients with MCL generally present with extensive lymphadenopathy and extranodal involvement. To the best of our knowledge, no cases of primary bone MCL with multiple vertebral compression fractures have been reported in the literature thus far. The current study reports the case of a 75-year-old Chinese male patient presenting with lower back pain for 1 year. B symptoms were not observed in the patient's medical history. X-ray revealed osteoporosis, and mixed osteolytic and osteosclerotic lesions in the T10 and L1 vertebrae with decreased height...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451858/biomechanical-in-vitro-comparison-of-radiofrequency-kyphoplasty-and-balloon-kyphoplasty
#16
Gerhard Achatz, Hans-Joachim Riesner, Benedikt Friemert, Raimund Lechner, Nicolas Graf, Hans-Joachim Wilke
PURPOSE: Balloon kyphoplasty (BK) has emerged as a popular method for treating osteoporosis vertebral compression fractures (OVCFs). In response to several shortcomings of BK, alternative methods have been introduced, among which is radiofrequency kyphoplasty (RFK). Biomechanical comparisons of BK and RFK are very sparse. The purpose of this study was to perform a biomechanical study in which BK and RFK are compared. METHODS: Each of the two study groups comprised six specimens prepared from two functional spinal units (FSUs) cut from fresh-frozen cadaveric spines (3 of T9-T11 and 3 of T12-L2)...
April 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28451512/spinal-compression-fracture-management-a-review-of-current-treatment-strategies-and-possible-future-avenues
#17
REVIEW
Ivo K Genev, Matthew K Tobin, Saher P Zaidi, Sajeel R Khan, Farid M L Amirouche, Ankit I Mehta
STUDY DESIGN: Narrative review. OBJECTIVE: Despite the numerous treatment options for vertebral compression fractures, a consensus opinion for the management of patients with these factures has not been established. This review is meant to provide an up-to-date overview of the most common treatment strategies for compression fractures and to suggest possible routes for the development of clearer treatment guidelines. METHODS: A comprehensive database search of PubMed was performed...
February 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28446993/minimally-invasive-surgical-techniques-for-management-of-painful-metastatic-and-primary-spinal-tumors
#18
REVIEW
Omid Hariri, Ariel Takayanagi, Dan E Miulli, Javed Siddiqi, Frank Vrionis
Patients with metastatic spinal disease are affected by disabling pain. The treatment of spinal metastases is focused on pain reduction and improvement in quality of life. Until recently, many patients with metastatic spinal disease did not qualify as surgical candidates due to the risks of surgery and length of recovery period. However, recent advances in minimally invasive surgery such as kyphoplasty and vertebroplasty allow patients to safely undergo surgery for pain relief with a short recovery period. The studies reviewed here suggest that vertebral augmentation is successful in reducing pain and disability scores in patients with painful metastases and multiple myeloma and are a safe modality to provide lasting pain relief...
March 24, 2017: Curēus
https://www.readbyqxmd.com/read/28445294/unilateral-versus-bilateral-percutaneous-kyphoplasty-for-osteoporotic-vertebral-compression-fractures-a-meta-analysis
#19
REVIEW
Wenli Chang, Xinyan Zhang, Ning Jiao, Peizhi Yuwen, Yanbin Zhu, Fei Zhang, Wei Chen
BACKGROUND: The debate on the efficacy of unilateral percutaneous kyphoplasty (UPKP) and bilateral percutaneous kyphoplasty (BPKP) for the treatment of osteoporotic vertebral compression fractures (OVCFs) is ongoing.This meta-analysis aimed to evaluate the clinical results of UPKP and BPKP in the treatment of OVCFs. METHODS: Web of Science, PubMed, Embase, and the Chinese Biomedical Database publication databases were searched using a date range of January 2008 to November 2016, for studies comparing UPKP and BPKP for the treatment of OVCFs...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28416837/-clinical-comparison-of-polymethylmethacrylate-and-bone-cement-in-the-treatment-of-osteoporotic-vertebral-compression-fractures-a-retrospective-study
#20
L P Shang, Y Tian, X G Liu
OBJECTIVE: To analyze the outcomes of patients with osteoporotic vertebral compression fractures treated with polymethylmethacrylate (PMMA) and GeneX bone cement in percutaneous kyphoplasty and to provide guidance in selecting the vertebral filling material for this procedure. METHODS: In this study, 86 patients with osteoporotic vertebral compression fractures treated at Peking University Third Hospital between June 2012 and June 2013 were retrospectively analyzed...
April 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
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