keyword
https://read.qxmd.com/read/38533097/-in-silico-identification-of-multi-target-inhibitors-from-medicinal-fungal-metabolites-against-the-base-excision-repair-pathway-proteins-of-african-swine-fever-virus
#21
JOURNAL ARTICLE
Mark Andrian B Macalalad, Fredmoore L Orosco
African swine fever virus (ASFV) has emerged as a serious threat to the pork industry resulting in significant economic losses and heightened concerns about food security. With no known cure presently available, existing control measures center on animal quarantine and culling. Considering the severity and challenges posed by ASFV, it is imperative to discover new treatment strategies and implement additional measures to prevent its further spread. This study recognized the potential of 1830 fungal metabolites from medicinal fungi as antiviral compounds against base excision repair (BER) proteins of ASFV, specifically ASFV AP, ASFV PolX, and ASFV Lig...
March 20, 2024: RSC Advances
https://read.qxmd.com/read/38532929/-there-is-nothing-that-can-prevent-me-from-supporting-her-men-s-perspectives-on-their-involvement-and-support-of-women-s-use-of-topical-therapy-for-cervical-precancer-treatment-in-kenya
#22
JOURNAL ARTICLE
Chemtai Mungo, Konyin Adewumi, Everlyn Adoyo, Graham Zulu, Supreet Kaur Goraya, Cirillus Ogollah, Jackton Omoto, Renée M Ferrari, Lisa Rahangdale
PURPOSE: Cervical cancer disproportionately impacts women in low- and middle-income countries (LMICs). The World Health Organization's (WHO) 90/70/90 strategy aims to eliminate cervical cancer by 2030 by increasing HPV vaccination coverage to 90%, screening 70% of eligible women, and effectively treating 90% of those with abnormal results by 2030, potentially preventing 62 million deaths in LMICs. LMICs, however, struggle with limited access to cervical precancer treatment, in part due to a lack of trained professionals and weak health systems...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38532864/randomized-clinical-trial-of-aspirin-as-prophylaxis-for-thromboembolism-in-hip-arthroplasty
#23
JOURNAL ARTICLE
Raul Carneiro Lins, Epitacio Rolim, Yago Andrade Lima, Rodrigo Rodrigues de Sousa Moura
OBJECTIVE: This study aims to evaluate aspirin as a chemical prophylaxis (200 mg) in total hip arthroplasty. METHODS: the study compared two groups and used ultrasonography (USG) to screen for low-deep venous thrombosis. Group 1 received 600 mg (control), and Group 2 received 200 mg of (intervention), associated with the use of elastic compression stockings and early walking. RESULTS: fourteen patients were allocated to Group A (200mg), and 16 to Group B (600mg); in group A (200mg), 3 cases with thrombus below the popliteal vein were detected at the first USG examination...
2024: Acta Ortopedica Brasileira
https://read.qxmd.com/read/38532435/liver-stiffness-and-associated-risk-factors-among-people-with-a-history-of-injecting-drugs-a-prospective-cohort-study
#24
JOURNAL ARTICLE
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T Fadnes
BACKGROUND: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances...
March 26, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38532378/biosafe-cerium-oxide-nanozymes-protect-human-pluripotent-stem-cells-and-cardiomyocytes-from-oxidative-stress
#25
JOURNAL ARTICLE
Chengwen Hang, Mohamed S Moawad, Zheyi Lin, Huixin Guo, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Yi-Han Chen, Jian Yang
BACKGROUND: Cardiovascular diseases (CVDs) have the highest mortality worldwide. Human pluripotent stem cells (hPSCs) and their cardiomyocyte derivatives (hPSC-CMs) offer a valuable resource for disease modeling, pharmacological screening, and regenerative therapy. While most CVDs are linked to significant over-production of reactive oxygen species (ROS), the effects of current antioxidants targeting excessive ROS are limited. Nanotechnology is a powerful tool to develop antioxidants with improved selectivity, solubility, and bioavailability to prevent or treat various diseases related to oxidative stress...
March 26, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38532046/experimental-study-on-the-impact-of-ids%C3%A2-%C3%A2-jfcs-complex-wetting-agent-on-the-characteristics-of-coal-bodies
#26
JOURNAL ARTICLE
Hongyang Wang, Lianman Xu, Zhijiao Qin, Xiaoliang Li, Xuejing Cao, Yumiao Han, Siqi Li, Yufei Ma, Siqi Gao, Lei Du, Fengshuo Yang
As China's coal mines have transitioned to deep mining, the ground stress within the coal seams has progressively increased, resulting in reduced permeability and poor wetting ability of conventional wetting agents. Consequently, these agents have become inadequate in fulfilling the requirements for preventing washouts during deep mining operations. In response to the aforementioned challenges, a solution was proposed to address the issues by formulating a composite wetting agent. This composite wetting agent combines a conventional surfactant with a chelating agent called tetrasodium iminodisuccinate (IDS)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531581/behavioural-mental-health-interventions-delivered-in-the-emergency-department-for-suicide-overdose-and-psychosis-a-scoping-review
#27
JOURNAL ARTICLE
Shannon M Nugent, Johanna Anderson, Sarah K Young
OBJECTIVE: To identify and describe evidence on brief emergency department (ED)-delivered behavioural and care process interventions among patients presenting with suicide attempt or acute ideation, substance overdose or psychosis. DESIGN: We employed a scoping review design and searched multiple data sources, clinical trial registries and references lists through March 2023. We included English-language trials and rigorously designed observational studies. In alignment with scoping review guidelines, we did not assess the quality of included studies or rate the strength of evidence of intervention effectiveness...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531562/clinical-practice-guideline-recommendations-to-improve-the-mental-health-of-adult-trauma-patients-protocol-for-a-systematic-review
#28
JOURNAL ARTICLE
Mélanie Bérubé, Nori Bradley, Meaghan O'Donnell, Henry Thomas Stelfox, Naisan Garraway, Helen-Maria Vasiliadis, Valerie Turcotte, Michel Perreault, Matthew Menear, Léonie Archambault, Juanita Haagsma, Hélène Provencher, Christine Genest, Marc-Aurèle Gagnon, Laurence Bourque, Alexandra Lapierre, Amal Khalfi, William Panenka
INTRODUCTION: Mental disorders are common in adult patients with traumatic injuries. To limit the burden of poor psychological well-being in this population, recognised authorities have issued recommendations through clinical practice guidelines (CPGs). However, the uptake of evidence-based recommendations to improve the mental health of trauma patients has been low until recently. This may be explained by the complexity of optimising mental health practices and interpretating CGPs scope and quality...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531427/outbreak-of-persistently-infected-heifer-calves-with-bovine-viral-diarrhea-virus-subgenotypes-1b-and-1d-in-a-bvdv-vaccinated-open-dairy-herd
#29
JOURNAL ARTICLE
Juliana Torres Tomazi Fritzen, Natalia Zaparoli Zucoloto, Elis Lorenzetti, Alice Fernandes Alfieri, Amauri Alcindo Alfieri
Bovine viral diarrhea virus (BVDV) infection has a significant economic impact on beef and dairy industries worldwide. Fetal infection with a non-cytopathic strain may lead to the birth of persistently infected (PI) offspring, which is the main event in the epidemiological chain of BVDV infection. This report describes the birth of 99 BVDV-PI heifer calves within 52 days of birth in a regular BVDV-vaccinated Brazilian dairy cattle herd and the subgenotypes of the infecting field strains. This study was conducted in a high-yielding open dairy cattle herd that frequently acquired heifers from neighboring areas for replacement...
March 24, 2024: Acta Tropica
https://read.qxmd.com/read/38531390/factors-associated-with-maternal-morbidity-among-black-women-in-the-united-states
#30
JOURNAL ARTICLE
Catrine Ibrahim Ibrahim Sous, William Moravec, Emily A DeFranco, Elizabeth Kelly, Robert M Rossi
OBJECTIVE: Non-Hispanic Black people (NHBP) have a 3-fold higher rate of maternal mortality compared to other racial groups. Racial disparities in maternal morbidity are well described however there are substantial differences in cultural, economic, and social determinants of health among racial groups. We sought to study the, at-risk, non-Hispanic Black population as its own cohort to identify factors most associated with severe maternal morbidity (SMM). METHODS: This is a population-based retrospective case control study of all livebirths in the U...
March 26, 2024: American Journal of Perinatology
https://read.qxmd.com/read/38531220/sesamin-alleviates-lipid-accumulation-induced-by-oleic-acid-via-pink1-parkin-mediated-mitophagy-in-hepg2-cells
#31
JOURNAL ARTICLE
Mengyun Dong, Tianliang Zhang, Xueli Liang, Xinyi Cheng, Fuyan Shi, Hang Yuan, Fengxiang Zhang, Qiqi Jiang, Xia Wang
Sesamin, a special compound present in sesame and sesame oil, has been reported a role in regulating lipid metabolism, while the underlying mechanisms remain unclear. Autophagy has been reported associated with lipid metabolism and regarded as a key modulator in liver steatosis. The present work aimed to investigate whether sesamin could exert its protective effects against lipid accumulation via modulating autophagy in HepG2 cells stimulated with oleic acid (OA). Cell viability was evaluated using the CCK-8 method, and triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein, cholesterol (LDL-C), alanine aminotransferase (ALT), along with aspartate aminotransferase (AST) were assessed by oil red O staining, transmission electron microscopy (TEM), and biochemical kits to investigate the lipid-lowering effects of sesamin...
March 22, 2024: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38531174/effect-of-increasing-cognitive-activity-participation-on-default-mode-network-in-older-adults-with-subjective-cognitive-decline-a-randomised-controlled-trial
#32
JOURNAL ARTICLE
Allen Ting Chun Lee, Yishan Luo, Zhaohua Huo, Lin Shi, Winnie Chiu Wing Chu, Linda Chiu Wa Lam
BACKGROUND: Having more cognitive activities may prevent dementia, but its evidence of modulating the functional brain network is limited. This randomised controlled trial (RCT) investigated the effect of increased cognitive activity participation on the default mode network (DMN) in older adults who had already been having regular cognitive activity participation and experiencing subjective cognitive decline (SCD). METHODS: Community-living Chinese individuals aged 55-75 years with regular practice of Chinese calligraphy and screened positive for SCD (but negative for mild cognitive impairment or dementia) were randomly allocated to either the intervention or control group...
March 25, 2024: EBioMedicine
https://read.qxmd.com/read/38530899/phosphocholine-induced-energy-source-shift-alleviates-mitochondrial-dysfunction-in-lung-cells-caused-by-geospecific-pm-2-5-components
#33
JOURNAL ARTICLE
Yuanyuan Song, Yanhao Zhang, Lin Zhu, Yanyan Chen, Yi-Jie Chen, Zhitong Zhu, Jieqing Feng, Zenghua Qi, Jian Zhen Yu, Zhu Yang, Zongwei Cai
Fine particulate matter (PM2.5 ) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM2.5 components to its toxicity, especially considering regional disparities. Moreover, prevention solutions for PM2.5 -associated health effects are scarce. In the present study, we comprehensively characterized and compared the primary PM2.5 constituents and their altered metabolites from two locations: Taiyuan and Guangzhou. Analysis of year-long PM2...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38530775/prevalence-and-concentration-of-pesticides-in-european-waters-a-protocol-for-systematic-review-and-meta-analysis
#34
JOURNAL ARTICLE
Manuel Serrano Valera, Nuria Vela, Grasiela Piuvezam, Francisco Mateo-Ramírez, Isac Davidson Santiago Fernandes Pimenta, Isabel Martínez-Alcalá
There is currently a growing interest in the so-called emerging pollutants, such as pesticides, pharmaceuticals, personal hygiene care products, drugs, etc., whose presence in natural ecosystems is not necessarily recent, but the development in latest years of new and more sensitive methods of analysis has allowed their detection. They can be present in the natural environment, food, and many products of everyday origin, which suggests that human exposure to them is massive and universal. Therefore, the study of this type of substances is becoming one of the priority lines of research of the main agencies dedicated to the protection of public and environmental health, such as the World Health Organization (WHO), United States Environmental Protection Agency (USEPA) or European Union (EU)...
2024: PloS One
https://read.qxmd.com/read/38530605/anti-n-methyl-d-aspartate-receptor-encephalitis-in-people-living-with-hiv-case-report-and-literature-review
#35
REVIEW
Jiangjin Hui, Jinhua Wang, Zhikai Wan, Qing Cao, Bohao Dai, Haiyan Lou, Biao Zhu
With the increase in the number of cases of autoimmune encephalitis (AE), the cerebrospinal fluid (CSF) of people living with HIV (PLWH) showing abnormal behavior, cognitive impairment or abnormal movements should be actively screened for the antibody panel of AE. Early recognition and treatment can prevent severe seizures or coma and markedly improve the prognosis of patients. The first-line immunotherapy for AE includes intravenous methylprednisolone and immunoglobulin. However, whether long-time immunosuppressive maintenance therapy is needed is debated...
March 26, 2024: Neurology and Therapy
https://read.qxmd.com/read/38530406/opportunistic-identification-of-vertebral-compression-fractures-on-ct-scans-of-the-chest-and-abdomen-using-an-ai-algorithm-in-a-real-life-setting
#36
JOURNAL ARTICLE
Magnus Grønlund Bendtsen, Mette Friberg Hitz
This study evaluated the performance of a vertebral fracture detection algorithm (HealthVCF) in a real-life setting and assessed the impact on treatment and diagnostic workflow. HealthVCF was used to identify moderate and severe vertebral compression fractures (VCF) at a Danish hospital. Around 10,000 CT scans were processed by the HealthVCF and CT scans positive for VCF formed both the baseline and 6-months follow-up cohort. To determine performance of the algorithm 1000 CT scans were evaluated by specialized radiographers to determine performance of the algorithm...
March 26, 2024: Calcified Tissue International
https://read.qxmd.com/read/38530346/computer-facilitated-screening-and-brief-intervention-for-alcohol-use-risk-in-adolescent-patients-of-pediatric-primary-care-offices-protocol-for-a-cluster-randomized-controlled-trial
#37
JOURNAL ARTICLE
Lydia A Shrier, Madison M O'Connell, Alessandra Torres, Laura P Shone, Alexander G Fiks, Julia A Plumb, Jessica L Maturo, Nicholas H McCaskill, Donna Harris, Pamela J Burke, Thatcher Felt, Marie Lynd Murphy, Lon Sherritt, Sion Kim Harris
BACKGROUND: Alcohol and other substance use disorders usually begin with substance use in adolescence. Pediatric primary care offices, where most adolescents receive health care, are a promising venue for early identification of substance use and for brief intervention to prevent associated problems and the development of substance use disorder. OBJECTIVE: This study tests the effects of a computer-facilitated screening and brief intervention (cSBI) system (the CRAFFT [Car, Relax, Alone, Forget, Family/Friends, Trouble] Interactive System [CRAFFT-IS]) on heavy episodic drinking, riding with a driver who is substance impaired, or driving while substance impaired among adolescents aged 14 to 17 years presenting for a well visit at pediatric primary care practices...
March 26, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38530314/transitional-neonatal-hypoglycemia-and-adverse-neurodevelopment-in-midchildhood
#38
JOURNAL ARTICLE
Marcia Roeper, Henrike Hoermann, Lisa M Körner, Marvin Sobottka, Ertan Mayatepek, Sebastian Kummer, Thomas Meissner
IMPORTANCE: The circumstances under which neonatal hypoglycemia leads to brain damage remain unclear due to a lack of long-term data on the neurodevelopment of affected children. As a result, diagnostic strategies and treatment recommendations are inconsistent. OBJECTIVE: To evaluate whether the occurrence of severe transitional neonatal hypoglycemia (defined as having at least 1 blood glucose measurement of 30 mg/dL or below) is associated with adverse neurodevelopment in midchildhood...
March 4, 2024: JAMA Network Open
https://read.qxmd.com/read/38530201/revealing-the-kinetic-phase-behavior-of-block-copolymer-complexes-using-solvent-vapor-absorption-desorption-isotherms
#39
JOURNAL ARTICLE
Nayanathara Hendeniya, Caden Chittick, Kaitlyn Hillery, Shaghayegh Abtahi, Curtis Mosher, Boyce Chang
Controlling the self-assembled morphologies in block copolymers heavily depends on their molecular architecture and processing conditions. Solvent vapor annealing is a versatile processive pathway to obtain highly periodic self-assemblies from high chi (χ) block copolymers (BCPs) and supramolecular BCP complexes. Despite the importance of navigating the energy landscape, controlled solvent vapor annealing (SVA) has not been investigated in BCP complexes, partly due to its intricate multicomponent nature...
March 26, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38530105/prevalence-and-predictors-of-colon-and-prostate-cancer-screening-among-volunteer-firefighters-the-united-states-firefighter-cancer-assessment-and-prevention-study
#40
JOURNAL ARTICLE
Nimit N Shah, Michael B Steinberg, Miriam M Calkins, Alberto J Caban-Martinez, Jefferey L Burgess, Elena Austin, Brittany S Hollerbach, Derrick L Edwards, Taylor M Black, Kathleen Black, Kaleigh M Hinton, Brian S Kubiel, Judith M Graber
BACKGROUND: Although firefighters have increased risk for colon and prostate cancer, limited information exists on screening practices for these cancers in volunteer firefighters who compose two-thirds of the US fire service. We estimated the prevalence of colon and prostate cancer screening among volunteer firefighters using eligibility criteria from 4 evidence-based screening recommendations and evaluated factors influencing screening. METHODS: We evaluated colon (n = 569) and prostate (n = 498) cancer screening prevalence in a sample of US volunteer firefighters using eligibility criteria from the US Preventive Services Taskforce (USPSTF), National Fire Protection Association, American Cancer Society, and National Comprehensive Cancer Network...
March 26, 2024: American Journal of Industrial Medicine
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