keyword
MENU ▼
Read by QxMD icon Read
search

Preventive screening

keyword
https://www.readbyqxmd.com/read/29169114/evaluation-of-antiparkinson-activity-of-ptupb-by-measuring-dopamine-and-its-metabolites-in-drosophila-melanogaster-lc-ms-ms-method-development
#1
Navya Lakkappa, Praveen T Krishnamurthy, Karthik Yamjala, Sung Hee Hwang, Bruce D Hammock, B Babu
Soluble epoxide hydrolase (sEH) inhibition is reported to elevate endogenous epoxyeicosatrienoic acids (EET's), which are known to play an important role in neuroprotection by inhibiting oxidative stress and neuroinflammation. In the present study, PTUPB, a dual inhibitor of sEH and COX-2, has been tested for its antiparkinson activity against rotenone (ROT) induced neurodegeneration in Drosophila model of Parkinson's disease (PD). To determine the efficacy and brain bioavailability of PTUPB a simple, rapid and sensitive LC-MS/MS method was developed and validated for the estimation of PTUPB (Method-I), dopamine (DA) and its metabolites (Method-II) in fly head...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29168273/synergistic-inhibition-of-cell-proliferation-by-combined-targeting-with-kinase-inhibitors-and-dietary-xanthone-is-a-promising-strategy-for-melanoma-treatment
#2
Y Xia, J Sun
α-Mangostin is a dietary xanthone that displays various biological activities, and numerous reports have shown its efficacy in cancer prevention and inhibition. As most agents have been shown to be ineffective as single-agent therapy for malignant melanoma (MM), the principle of targeted chemotherapy for MM is to use effective inhibitors and combination methods. In this study, we tested the cytotoxicity of several kinase inhibitors, including the glycogen synthase kinase (GSK)-3 inhibitor CHIR99021, and rapamycin, in combination with a dietary xanthone, α-mangostin, by screening from a kinase inhibitor library for melanogenesis in SK-MEL-2 MM cells, and verified these by clone formation efficiency, terminal dUTP nick end labelling, and expression of apoptosis-related proteins...
November 22, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/29168244/using-preceding-hospital-admissions-to-identify-children-at-risk-of-developing-acute-rheumatic-fever
#3
Jane Oliver, Tim Foster, Deborah A Williamson, Nevil Pierse, Michael G Baker
AIMS: New Zealand (NZ) Māori and Pacific children have high rates of acute rheumatic fever (ARF). Around 150 new cases arise each year. As part of the national ARF prevention programme, funding is available to improve housing. To obtain maximum benefit from interventions, an effective tool is needed for targeting high-risk children. This study aimed to assess the effectiveness of using hospitalisations for identifying children at risk of subsequent ARF. METHODS: Three potentially avoidable hospitalisation (PAH) groups were investigated, including diseases thought to be influenced by housing...
November 23, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29168066/changes-in-anxiety-and-depression-symptoms-predict-sexual-risk-behaviors-among-young-men-living-in-dar-es-salaam-tanzania
#4
Lauren M Hill, Nisha C Gottfredson, Lusajo J Kajula, Brian W Pence, Vivian F Go, James Moody, Suzanne Maman
Young men are important targets in HIV prevention in Tanzania and throughout sub-Saharan Africa. Anxiety and depression are common among youth and may be important predictors of HIV risk behaviors; evidence of these relationships in high-risk populations is needed. Using baseline and 1 year follow-up assessments from an HIV prevention trial we assessed the association between changes in symptoms of anxiety and depression and follow-up sexual risk behaviors (condom use and sexual partner concurrency) controlling for baseline sexual risk behaviors among 1113 male members of social groups known as "camps" in Dar es Salaam, Tanzania...
November 22, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29167076/the-convergence-of-two-epidemics-vitamin-d-deficiency-in-obese-school-aged-children
#5
REVIEW
Linda Cheng
PROBLEM: Vitamin D deficiency (VDD) and obesity are two interrelated global epidemics that affect school-aged children. This article will review the relationship between VDD and obesity in school-aged children and implications it has for the pediatric nurse (PN). ELIGIBILITY CRITERIA: Original articles of studies, review articles and meta-analyses were selected from the past 5years and pooled for review. These included obese school-aged children who had vitamin D insufficiency...
October 18, 2017: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29166732/-application-of-pegylated-recombinant-human-granulocyte-colony-stimulating-factor-to-prevent-chemotherapy-induced-neutropenia-in-patients-with-lymphoma-a-prospective-multicenter-open-label-clinical-trial
#6
H Q Huang, B Bai, Y H Gao, D H Zou, S H Zou, H Tan, Y P Song, Z Y Li, J Jin, W Li, H Su, Y P Gong, M Z Zhong, Y R Shuang, J Zhu, J Q Zhang, Z Cai, Q L Teng, W J Sun, Y Yang, Z J Xia, H L Chen, L M Hua, Y Y Bao, N Wu
Objective: To evaluate the efficacy and safety of pegylated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) in prophylaxis neutropenia after chemotherapy in patients with lymphoma. Methods: This was a multicenter, single arm, open, phase Ⅳ clinical trial. Included 410 patients with lymphoma received multiple cycles of chemotherapy and PEG-rhG-CSF was administrated as prophylactic. The primary endpoint was the incidence of Ⅲ/Ⅳ grade neutropenia and febrile neutropenia (FN) after each chemotherapy cycle...
October 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/29166444/patterns-of-tobacco-consumption-among-residents-of-a-rural-settlement-a-cross-sectional-study
#7
Andrécia Cósmem da Silva, Lorena Silva Vargas, Roselma Lucchese, Bruno de Souza Calixto, Rafael Alves Guimarães, Ivania Vera, Paulo Alexandre de Castro, Valéria Pagotto, Inaina Lara Fernandes
OBJECTIVE: Investigate patterns and factors associated with tobacco consumption among residents of a rural settlement. METHODS: A cross-sectional study conducted between September and November 2014, with 172 residents of a rural settlement in the Midwest region of Brazil. We analyzed as dependent variables tobacco consumption at some point in life; current tobacco consumption; tobacco abuse; and the high risk of nicotine dependence, with sociodemographic variables associated with tobacco use, and we applied the Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST) and Self-Reporting Questionnaire (SRQ-20)...
2017: Revista de Saúde Pública
https://www.readbyqxmd.com/read/29166191/the-pediatric-yorkhill-malnutrition-score-is-a-reliable-malnutrition-screening-tool
#8
Nur Eni Lestari, Nani Nurhaeni, Dessie Wanda
Children often experience malnutrition while they are hospitalized. Therefore, the prevention of malnutrition and nutritional management need to be done properly using malnutrition screening tools. This study aimed to determine the sensitivity and specificity of the Pediatric Yorkhill Malnutrition Score (PYMS) and the Screening Tool for the Risk of Impaired Nutritional Status and Growth (STRONGkids) when compared to the Subjective Global Nutritional Assessment for Children (SGNA). This study involved 81 pediatric patients with ages ranging from 1 to 16 years old...
2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29165152/detection-of-antibiotic-resistant-acinetobacter-baumannii-in-various-hospital-environments-potential-sources-for-transmission-of-acinetobacter-infections
#9
Zahra Shamsizadeh, Mahnaz Nikaeen, Bahram Nasr Esfahani, Seyed Hamed Mirhoseini, Maryam Hatamzadeh, Akbar Hassanzadeh
BACKGROUND: Antibiotic resistant Acinetobacter baumannii has emerged as one of the most problematic hospital acquired pathogens around the world. This study was designed to investigate the presence of antibiotic resistant A. baumannii in various hospital environments. METHODS: Air, water and inanimate surface samples were taken in different wards of four hospitals and analyzed for the presence of A. baumannii. Confirmed A. baumannii isolates were analyzed for antimicrobial susceptibility and also screened for the presence of three most common OXA- type carbapenemase-encoding genes...
May 8, 2017: Environmental Health and Preventive Medicine
https://www.readbyqxmd.com/read/29165003/administrators-perceptions-of-oral-health-care-and-cancer-screening-in-long-term-care-nursing-facilities
#10
Peter Maramaldi, Tamara Cadet, Shanna Burke, Mary LeCloux, Erina White, Taru Hannele Kinnunen, Elsbeth Kalenderian
An estimated 1.7 million adults in the United States more than the age of 65 reside in long-term care nursing facilities (LTCNFs), and only 17% of them receive dental care. More than 83% of LTCNF residents require assistance with oral care. Adequate dental care is a preventative behavior for oral cancer. Adults more than age 65 will account for 60% of oral cancer-related deaths, despite an 80% cure rate for early diagnosis. This study sought to expand knowledge of the perceived benefits, barriers, and ability to perform or provide for oral health care and oral cancer screening as reported by Administrators and Directors of Nursing in LTCNFs...
October 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/29164797/impact-of-systolic-blood-pressure-on-the-safety-and-tolerability-of-initiating-and-up-titrating-sacubitril-valsartan-in-patients-with-heart-failure-and-reduced-ejection-fraction-insights-from-the-titration-study
#11
Michele Senni, John J V McMurray, Rolf Wachter, Hugh F McIntyre, Inder S Anand, Vincenzo Duino, Arnab Sarkar, Victor Shi, Alan Charney
AIMS: The TITRATION trial investigated two strategies to initiate and up-titrate sacubitril/valsartan (LCZ696) to the same target dose, over a condensed (3-week) or conservative (6-week) period, in patients with heart failure with reduced ejection fraction (HFrEF) and systolic blood pressure (SBP) of ≥100 mmHg. This post hoc analysis examined the relationship between baseline SBP at screening and achievement of the target dose of sacubitril/valsartan of 97 mg/103 mg (also termed 'LCZ696 200 mg') twice per day during the study...
November 22, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29164718/canine-prostate-specific-esterase-cpse-as-an-useful-biomarker-in-preventive-screening-programme-of-canine-prostate-cpse-threshold-value-assessment-and-its-correlation-with-ultrasonographic-prostatic-abnormalities-in-asymptomatic-dogs
#12
S Alonge, M Melandri, R Leoci, G M Lacalandra, G Aiudi
Due to the increased attention that pet-owners devote to their animals and to the improved veterinary care, investigations regarding methods to early detect prostatic disorders that might affect canine life quality have been performed. Canine prostate specific esterase (CPSE) concentration was reported to be higher in dogs suffering from prostatic diseases. This study aimed to estimate the CPSE threshold as a biomarker to early identify prostatic diseases in asymptomatic dogs. The ultrasonographic examination of the prostate was performed in 19 dogs (6-40 kg; 1-5 years) with no symptoms of prostatic diseases...
November 22, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/29164562/resveratrol-transcriptionally-regulates-mirna-18a-5p-expression-ameliorating-diabetic-nephropathy-via-increasing-autophagy
#13
X-H Xu, D-F Ding, H-J Yong, C-L Dong, N You, X-L Ye, M-L Pan, J-H Ma, Q You, Y-B Lu
OBJECTIVE: To investigate the effects of resveratrol on autophagy in the chronically diabetic nephropathy and to study the effects of the different expression of microRNAs after resveratrol (RSV) treated in db/db mice (diabetic mice). MATERIALS AND METHODS: Db/m (non- diabetic) and db/db mice were randomly divided into intra gastric RSV treatment group or control group. Renal tissues were prepared for HE/PAS staining. In vitro, mouse podocytes cell lines were grown in different mediums with different dose of resveratrol treatment...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29164013/physician-adherence-to-sexually-transmitted-infection-screening-guidelines-in-an-ob-gyn-teaching-clinic-in-hawai-i
#14
Alyssa Dee P Carlson, Mary Tschann, Somsook Santibenchakul, Eric L Hurwitz, Jennifer Salcedo
Rates of chlamydia (CT) and gonorrhea (GC) have risen for the first time in the United States since 2006. Certain population groups are disproportionately affected by these sexually transmitted infections (STIs) as well as HIV. The Centers for Disease Control and Prevention (CDC) and professional societies have published screening guidelines for these STIs for women under the age of 25. We aimed to quantify physician adherence to GC/CT and HIV screening guidelines and to determine demographic factors associated with GC/CT and HIV screening recommendations among women 14-25 years old in Honolulu, Hawai'i...
November 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/29163939/infection-prevention-and-control-measures-and-tools-for-the-prevention-of-entry-of-carbapenem-resistant-enterobacteriaceae-into-healthcare-settings-guidance-from-the-european-centre-for-disease-prevention-and-control
#15
A P Magiorakos, K Burns, J Rodríguez Baño, M Borg, G Daikos, U Dumpis, J C Lucet, M L Moro, E Tacconelli, G Skov Simonsen, E Szilágyi, A Voss, J T Weber
Background: Infections with carbapenem-resistant Enterobacteriaceae (CRE) are increasingly being reported from patients in healthcare settings. They are associated with high patient morbidity, attributable mortality and hospital costs. Patients who are "at-risk" may be carriers of these multidrug-resistant Enterobacteriaceae (MDR-E).The purpose of this guidance is to raise awareness and identify the "at-risk" patient when admitted to a healthcare setting and to outline effective infection prevention and control measures to halt the entry and spread of CRE...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29163416/diagnostic-evasion-of-highly-resistant-microorganisms-a-critical-factor-in-nosocomial-outbreaks
#16
Xuewei Zhou, Alexander W Friedrich, Erik Bathoorn
Highly resistant microorganisms (HRMOs) may evade screening strategies used in routine diagnostics. Bacteria that have evolved to evade diagnostic tests may have a selective advantage in the nosocomial environment. Evasion of resistance detection can result from the following mechanisms: low-level expression of resistance genes not resulting in detectable resistance, slow growing variants, mimicry of wild-type-resistance, and resistance mechanisms that are only detected if induced by antibiotic pressure. We reviewed reports on hospital outbreaks in the Netherlands over the past 5 years...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162807/molecular-basis-of-akap79-regulation-by-calmodulin
#17
Neha Patel, Florian Stengel, Ruedi Aebersold, Matthew G Gold
AKAP79/150 is essential for coordinating second messenger-responsive enzymes in processes including synaptic long-term depression. Ca(2+) directly regulates AKAP79 through its effector calmodulin (CaM), but the molecular basis of this regulation was previously unknown. Here, we report that CaM recognizes a '1-4-7-8' pattern of hydrophobic amino acids starting at Trp79 in AKAP79. Cross-linking coupled to mass spectrometry assisted mapping of the interaction site. Removal of the CaM-binding sequence in AKAP79 prevents formation of a Ca(2+)-sensitive interface between AKAP79 and calcineurin, and increases resting cellular PKA phosphorylation...
November 22, 2017: Nature Communications
https://www.readbyqxmd.com/read/29162494/prevalence-of-multidrug-resistant-organisms-in-migrant-children-admitted-to-an-italian-cardiac-surgery-department-2015-2016
#18
E Costa, M Tejada, P Gaia, M Cornetta, A Moroni, E Carfora, R Valaperta, C De Siena, N Moussaidi, G Isgrò, A Frigiola
Screening on hospital admission to identify multidrug-resistant organism (MDRO) colonization is a frequently discussed topic. We report the results of microbiological screening in 141 Italian and 354 migrant children candidates for cardiac surgery conducted in 2015-2016. In all, 25% of Italian children and more than 65.4% of African and Romanian children carried at least one MDRO (meticillin-resistant Staphylococcus aureus; extended-spectrum β-lactamase enzymes; carbapenemase producers; and vancomycin-resistant enterococci)...
November 18, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29162421/past-current-and-future-incidence-rates-and-burden-of-metastatic-prostate-cancer-in-the-united-states
#19
Scott P Kelly, William F Anderson, Philip S Rosenberg, Michael B Cook
BACKGROUND: Metastatic prostate cancer (PCA) remains a highly lethal malignancy in the USA. As prostate-specific antigen testing declines nationally, detailed assessment of current age- and race-specific incidence trends and quantitative forecasts are needed. OBJECTIVE: To evaluate the current trends of metastatic PCA by age and race, and forecast the number of new cases (annual burden) and future trends. DESIGN, SETTING, AND PARTICIPANTS: We derived incidence data for men aged ≥45 yr who were diagnosed with metastatic PCA from the population-based Surveillance, Epidemiology, and End Results registries...
November 18, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29162209/an-outbreak-of-chickenpox-in-an-asylum-seeker-centre-in-italy-outbreak-investigation-and-validity-of-reported-chickenpox-history-december-2015-may-2016
#20
Francesco Vairo, Virginia Di Bari, Vincenzo Panella, Giuseppe Quintavalle, Saul Torchia, Maria Cristina Serra, Maria Teresa Sinopoli, Maurizio Lopalco, Giancarlo Ceccarelli, Federica Ferraro, Sabrina Valle, Licia Bordi, Maria Rosaria Capobianchi, Vincenzo Puro, Paola Scognamiglio, Giuseppe Ippolito, The Outbreak Investigation Group
An outbreak of chickenpox occurred between December 2015 and May 2016 among asylum seekers in a reception centre in Latium, Italy. We describe the epidemiological and laboratory investigations, control measures and validity of reported history of chickenpox infection. Serological screening of all residents and incoming asylum seekers was performed, followed by vaccine offer to all susceptible individuals without contraindication. Forty-six cases were found and 41 were associated with the outbreak. No complications, hospitalisations or deaths occurred...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
keyword
keyword
118092
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"