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Preventive screening

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https://www.readbyqxmd.com/read/28109735/implementation-and-evaluation-of-two-educational-strategies-to-improve-screening-for-eating-disorders-in-pediatric-primary-care
#1
Holly C Gooding, Elizabeth Cheever, Sara F Forman, Jonathan Hatoun, Farah Jooma, Currie Touloumtzis, Louis Vernacchio
PURPOSE: Routine screening for disordered eating or body image concerns is recommended by the American Academy of Pediatrics. We evaluated the ability of two educational interventions to increase screening for eating disorders in pediatric primary care practice, predicting that the "active-learning" group would have an increase in documented screening after intervention. METHODS: We studied 303 practitioners in a large independent practice association located in the northeastern United States...
January 18, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28109436/combining-click-chemistry-based-proteomics-with-dox-inducible-gene-expression
#2
J Gebert, M Schnölzer, U Warnken, J Kopitz
Inactivating mutations in single genes can trigger, prevent, promote, or alleviate diseases. Identifying such disease-related genes is a main pillar of medical research. Since proteins play a crucial role in mediating these effects, their impact on the diseased cells' proteome including posttranslational modifications has to be elucidated for a detailed understanding of the role of these genes in the disease process. In complex disorders, like cancer, several genes contribute to the disease process, thereby hampering the assignment of a proteomic change to the corresponding causative gene...
2017: Methods in Enzymology
https://www.readbyqxmd.com/read/28109337/paying-for-sex-by-young-men-who-live-on-the-streets-in-dhaka-city-compounded-sexual-risk-in-a-vulnerable-migrant-community
#3
Tracy L McClair, Tarik Hossain, Nargis Sultana, Brady Burnett-Zieman, Eileen A Yam, Sharif Hossain, Reena Yasmin, Najmus Sadiq, Michele R Decker, Saifuddin Ahmed
PURPOSE: Dhaka City is home to thousands of migrants from Bangladesh's rural areas who often live in the streets. Prior studies examine street youth's practice of selling sex as a survival mechanism. We assess their less-studied practice of paying for sex and its association with sexual risk behaviors and outcomes. METHODS: As part of the global Link Up project, trained interviewers recruited 447 young men who live on the streets, ages 15-24, from seven Dhaka City "hotspots" to participate in a survey about sexual health...
February 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28109251/prevalence-and-trends-of-metabolic-syndrome-among-adults-in-the-asia-pacific-region-a-systematic-review
#4
P Ranasinghe, Y Mathangasinghe, R Jayawardena, A P Hills, A Misra
BACKGROUND: The Asia-Pacific region is home to nearly half of the world's population. The region has seen a recent rapid increase in the prevalence of obesity, type-2 diabetes and cardiovascular disease. The present systematic review summarizes the recent prevalence and trends of Metabolic Syndrome (MetS) among adults in countries of the Asia-Pacific Region. METHODS: Data on MetS in Asia-Pacific countries were obtained using a stepwise process by searching the online Medline database using MeSH terms 'Metabolic Syndrome X' and 'Epidemiology/EP'...
January 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28109006/attitudes-towards-non-invasive-prenatal-diagnosis-among-obstetricians-in-pakistan-a-developing-islamic-country
#5
Shenaz Ahmed, Hussain Jafri, Yasmin Rashid, Gerald Mason, Yasmin Ehsan, Mushtaq Ahmed
OBJECTIVES: Stakeholders' views are essential for informing implementation strategies for non-invasive prenatal testing (NIPT). Little is known about such views in developing countries. We explored attitudes toward NIPT among obstetricians in Pakistan, a developing Islamic country. METHODS: A 35-item questionnaire was distributed and collected at eight events (a national conference and seven workshops in five cities) for obstetric professionals on advances in fetal medicine...
January 20, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28108441/child-with-multiple-fractures-a-rare-presentation-of-a-common-disease
#6
Filipa Dias Costa, Carla Maia, Susana Almeida, Ricardo Ferreira
Bone fractures are not uncommon in paediatric age. However, when recurrent, an underlying clinical condition must not be excluded. We describe the case of a boy aged 7 years, referred for investigation of recurrent bone fractures. Personal and family histories were unremarkable. Physical examination was normal. Almost all primary bone disorders were excluded. Additional laboratory investigations ruled out the majority of secondary causes of bone fragility. Coeliac disease (CD) serologies, however, were positive, and duodenal biopsies confirmed this diagnosis (Marsh III B)...
January 20, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28107340/association-of-diabetes-related-complications-with-heart-rate-variability-among-a-diabetic-population-in-the-uae
#7
Ahsan H Khandoker, Haitham M Al-Angari, Kinda Khalaf, Sungmun Lee, Wael Almahmeed, Habiba S Al Safar, Herbert F Jelinek
Microvascular, macrovascular and neurological complications are the key causes of morbidity and mortality among type II diabetes mellitus (T2DM) patients. The aim of this study was to investigate the alterations of cardiac autonomic function of diabetic patients in relation to three types of diabetes-related complications. ECG recordings were collected and analyzed from 169 T2DM patients in supine position who were diagnosed with nephropathy (n = 55), peripheral neuropathy (n = 64) and retinopathy (n = 106) at two hospitals in the UAE...
2017: PloS One
https://www.readbyqxmd.com/read/28106821/a-protective-vaccine-against-chlamydia-genital-infection-using-vault-nanoparticles-without-an-added-adjuvant
#8
Janina Jiang, Guangchao Liu, Valerie A Kickhoefer, Leonard H Rome, Lin-Xi Li, Stephen J McSorley, Kathleen A Kelly
Chlamydia trachomatis genital infection is the most common sexually transmitted bacterial disease, causing a significant burden to females due to reproductive dysfunction. Intensive screening and antibiotic treatment are unable to completely prevent female reproductive dysfunction, thus, efforts have become focused on developing a vaccine. A major impediment is identifying a safe and effective adjuvant which induces cluster of differentiation 4 (CD4) cells with attributes capable of halting genital infection and inflammation...
January 19, 2017: Vaccines
https://www.readbyqxmd.com/read/28105916/gpcrs-from-fusarium-graminearum-detection-modeling-and-virtual-screening-the-search-for-new-routes-to-control-head-blight-disease
#9
Emmanuel Bresso, Roberto Togawa, Kim Hammond-Kosack, Martin Urban, Bernard Maigret, Natalia Florencio Martins
BACKGOUND: Fusarium graminearum (FG) is one of the major cereal infecting pathogens causing high economic losses worldwide and resulting in adverse effects on human and animal health. Therefore, the development of new fungicides against FG is an important issue to reduce cereal infection and economic impact. In the strategy for developing new fungicides, a critical step is the identification of new targets against which innovative chemicals weapons can be designed. As several G-protein coupled receptors (GPCRs) are implicated in signaling pathways critical for the fungi development and survival, such proteins could be valuable efficient targets to reduce Fusarium growth and therefore to prevent food contamination...
December 15, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28105853/identification-of-potential-molecular-associations-between-chikungunya-virus-non-structural-protein-2-and-human-host-proteins
#10
J Rana, S Gulati, S Rajasekharan, A Gupta, V Chaudhary, S Gupta
Chikungunya virus (CHIKV) non-structural protein 2 (nsP2) is considered to be the master regulator of viral RNA replication and host responses generated during viral infection. This protein has two main functional domains: an N-terminal domain which exhibits NTPase, RNA triphosphatase and helicase activities and a C-terminal protease domain. Understanding how CHIKV nsP2 interacts with its host proteins is essential for elucidating all the required processes for viral replication and pathogenesis along with the identification of potential targets for antiviral therapy...
January 19, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28104998/clinical-assessments-and-care-interventions-to-promote-oral-hydration-amongst-older-patients-a-narrative-systematic-review
#11
Lloyd L Oates, Christopher I Price
BACKGROUND: Older patients in hospital may be unable to maintain hydration by drinking, leading to intravenous fluid replacement, complications and a longer length of stay. We undertook a systematic review to describe clinical assessment tools which identify patients at risk of insufficient oral fluid intake and the impact of simple interventions to promote drinking, in hospital and care home settings. METHOD: MEDLINE, CINAHL, and EMBASE databases and two internet search engines (Google and Google Scholar) were examined...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28104747/the-goddard-and-saturn-genes-are-essential-for-drosophila-male-fertility-and-may-have-arisen-de-novo
#12
Anna M Gubala, Jonathan F Schmitz, Michael J Kearns, Tery T Vinh, Erich Bornberg-Bauer, Mariana F Wolfner, Geoffrey D Findlay
New genes arise through a variety of mechanisms, including the duplication of existing genes and the de novo birth of genes from non-coding DNA sequences. While there are numerous examples of duplicated genes with important functional roles, the functions of de novo genes remain largely unexplored. Many newly evolved genes are expressed in the male reproductive tract, suggesting that these evolutionary innovations may provide advantages to males experiencing sexual selection. Using testis-specific RNA interference, we screened 11 putative de novo genes in Drosophila melanogaster for effects on male fertility and identified two, goddard and saturn, that are essential for spermatogenesis and sperm function...
January 19, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28103896/sexual-and-reproductive-health-services-utilization-by-female-sex-workers-is-context-specific-results-from-a-cross-sectional-survey-in-india-kenya-mozambique-and-south-africa
#13
Yves Lafort, Ross Greener, Anuradha Roy, Letitia Greener, Wilkister Ombidi, Faustino Lessitala, Jolene Skordis-Worrall, Mags Beksinska, Peter Gichangi, Sushena Reza-Paul, Jenni A Smit, Matthew Chersich, Wim Delva
BACKGROUND: Female sex workers (FSWs) are extremely vulnerable to adverse sexual and reproductive health (SRH) outcomes. To mitigate these risks, they require access to services covering not only HIV prevention but also contraception, cervical cancer screening and sexual violence. To develop context-specific intervention packages to improve uptake, we identified gaps in service utilization in four different cities. METHODS: A cross-sectional survey was conducted, as part of the baseline assessment of an implementation research project...
January 19, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28103883/performance-of-loop-mediated-isothermal-amplification-lamp-for-the-diagnosis-of-malaria-among-malaria-suspected-pregnant-women-in-northwest-ethiopia
#14
Banchamlak Tegegne, Sisay Getie, Wossenseged Lemma, Abu Naser Mohon, Dylan R Pillai
BACKGROUND: Malaria is a major public health problem and an important cause of maternal and infant morbidity in sub-Saharan Africa, including Ethiopia. Early and accurate diagnosis of malaria with effective treatment is the best strategy for prevention and control of complications during pregnancy and infant morbidity and mortality. However, laboratory diagnosis has relied on the identification of malaria parasites and parasite antigens in peripheral blood using Giemsa-stained microscopy or rapid diagnostic tests (RDTs) which lack analytical and clinical sensitivity...
January 19, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28103838/race-and-bmi-modify-associations-of-calcium-and-vitamin-d-intake-with-prostate-cancer
#15
Ken Batai, Adam B Murphy, Maria Ruden, Jennifer Newsome, Ebony Shah, Michael A Dixon, Elizabeth T Jacobs, Courtney M P Hollowell, Chiledum Ahaghotu, Rick A Kittles
BACKGROUND: African Americans have disproportionately higher burden of prostate cancer compared to European Americans. However, the cause of prostate cancer disparities is still unclear. Several roles have been proposed for calcium and vitamin D in prostate cancer pathogenesis and progression, but epidemiologic studies have been conducted mainly in European descent populations. Here we investigated the association of calcium and vitamin D intake with prostate cancer in multiethnic samples...
January 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28103571/identification-of-aurintricarboxylic-acid-as-a-selective-inhibitor-of-the-tweak-fn14-signaling-pathway-in-glioblastoma-cells
#16
Alison Roos, Harshil D Dhruv, Ian T Mathews, Landon J Inge, Serdar Tuncali, Lauren K Hartman, Donald Chow, Nghia Millard, Holly H Yin, Jean Kloss, Joseph C Loftus, Jeffrey A Winkles, Michael E Berens, Nhan L Tran
The survival of patients diagnosed with glioblastoma (GBM), the most deadly form of brain cancer, is compromised by the proclivity for local invasion into the surrounding normal brain, which prevents complete surgical resection and contributes to therapeutic resistance. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) superfamily, can stimulate glioma cell invasion and survival via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the transcription factor NF-κB...
January 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28103209/west-nile-virus-and-other-nationally-notifiable-arboviral-diseases-united-states-2015
#17
Elisabeth Krow-Lucal, Nicole P Lindsey, Jennifer Lehman, Marc Fischer, J Erin Staples
Arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. The leading cause of domestically acquired arboviral disease in the United States is West Nile virus (WNV) (1). Other arboviruses, including La Crosse, St. Louis encephalitis, Jamestown Canyon, Powassan, and eastern equine encephalitis viruses, also cause sporadic cases and outbreaks. This report summarizes surveillance data reported to CDC in 2015 for nationally notifiable arboviruses...
January 20, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28103184/using-the-centers-for-disease-control-and-prevention-s-stay-independent-checklist-to-engage-a-community-of-american-indians-and-raise-awareness-about-risk-of-falls-2016
#18
Janet Popp, Debra L Waters, Karen Leekity, Donica Ghahate, Jeanette Bobelu, Ross Tsikewa, Carla J Herman, Vallabh Shah
BACKGROUND: The unintentional death rate from falls is higher among American Indians from the US Southwest than from other regions in the country. The Zuni Pueblo is a geographically isolated, rural American Indian community located in western New Mexico. Education and screening for falls risk is lacking in this community and may be needed to reduce falls and falls-related illness and death. COMMUNITY CONTEXT: Building on a 17-year relationship with the Zuni Health Initiative, meetings were held with Zuni tribal leadership, staff from the Zuni Senior Center and Zuni Home Health Services, members of the Zuni Comprehensive Community Health Center, Indian Health Service, and Zuni community health representatives (CHRs) to discuss elder falls in the community...
January 19, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28103075/a-community-based-randomized-trial-of-hepatitis-b-screening-among-high-risk-vietnamese-americans
#19
Grace X Ma, Carolyn Y Fang, Brenda Seals, Ziding Feng, Yin Tan, Philip Siu, Ming Chin Yeh, Sarit A Golub, Minhhuyen T Nguyen, Tam Tran, Minqi Wang
OBJECTIVES: To evaluate the effectiveness of a community-based liver cancer prevention program on hepatitis B virus (HBV) screening among low-income, underserved Vietnamese Americans at high risk. METHODS: We conducted a cluster randomized trial involving 36 Vietnamese community-based organizations and 2337 participants in Pennsylvania, New Jersey, and New York City between 2009 and 2014. We randomly assigned 18 community-based organizations to a community-based multilevel HBV screening intervention (n = 1131)...
January 19, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28103073/multilevel-prevention-trial-of-alcohol-use-among-american-indian-and-white-high-school-students-in-the-cherokee-nation
#20
Kelli A Komro, Melvin D Livingston, Alexander C Wagenaar, Terrence K Kominsky, Dallas W Pettigrew, Brady A Garrett
OBJECTIVES: To evaluate the effectiveness of a multilevel intervention designed to prevent underage alcohol use among youths living in the Cherokee Nation. METHODS: We randomly assigned 6 communities to a control, Communities Mobilizing for Change on Alcohol (CMCA; a community-organizing intervention targeting alcohol access) only, CONNECT (a school-based universal screening and brief intervention) only, or a combined condition. We collected quarterly surveys 2012-2015 from students starting in 9th and 10th grades and ending in 11th and 12th grades...
January 19, 2017: American Journal of Public Health
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