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Late onset psychosis

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https://www.readbyqxmd.com/read/28643852/therapeutic-d2-3-receptor-occupancies-and-response-with-low-amisulpride-blood-concentrations-in-very-late-onset-schizophrenia-like-psychosis-vloslp
#1
Suzanne Reeves, Kate Eggleston, Elizabeth Cort, Emma McLachlan, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, Joel Dunn, Paul Marsden, Robert Kessler, David Taylor, Julie Bertrand, Robert Howard
OBJECTIVE: Antipsychotic drug sensitivity in very late-onset schizophrenia-like psychosis (VLOSLP) is well documented, but poorly understood. This study aimed to investigate blood drug concentration, D2/3 receptor occupancy and outcome in VLOSLP during open amisulpride prescribing, and compare this with Alzheimer's disease (AD). METHODS: Blood drug concentration, prolactin, symptoms and extrapyramidal side-effects (EPS) were serially assessed during dose titration...
June 23, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28560931/psychosis-and-dementia-risk-factor-prodrome-or-cause
#2
Corinne E Fischer, Luis Agüera-Ortiz
BACKGROUND: Progression of dementia is often associated with the emergence of neuropsychiatric symptoms (NPS), though there is recent evidence that NPS may occur in prodromal dementia (PrD) and impact clinical course. Mood and anxiety symptoms are the NPS that tend to occur most frequently in PrD and thus have been most extensively studied. Comparatively, there has been little focus on psychotic symptoms in PrD. METHODS: The authors review the existing literature on psychosis in PrD, including the functional psychosis of early and late onset, with a focus on epidemiology, phenomenology, and clinical course and treatment considerations...
May 31, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28552767/parenteral-nanoemulsions-of-risperidone-for-enhanced-brain-delivery-in-acute-psychosis-physicochemical-and-in-vivo-performances
#3
Sanela M Đorđević, Anja Santrač, Nebojša D Cekić, Bojan D Marković, Branka Divović, Tanja M Ilić, Miroslav M Savić, Snežana D Savić
This work aimed to deepen the lately acquired knowledge about parenteral nanoemulsions as carriers for brain delivery of risperidone, a poorly water-soluble antipsychotic drug, through establishing the prospective relationship between their physicochemical, pharmacokinetic, biodistribution, and behavioral performances. For this purpose, two optimized risperidone-loaded nanoemulsions, stabilized by lecithin or lecithin/polysorbate 80 mixture, and costabilized by sodium oleate, were produced by high-pressure homogenization...
May 25, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28541731/usher-syndrome-and-late-onset-psychosis
#4
Arun Gupta, Tarun Bastiampillai
No abstract text is available yet for this article.
June 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28458550/psychosis-in-behavioral-variant-frontotemporal-dementia
#5
Flora T Gossink, Everard Gb Vijverberg, Welmoed Krudop, Philip Scheltens, Max L Stek, Yolande Al Pijnenburg, Annemiek Dols
BACKGROUND: Dementia is generally characterized by cognitive impairment that can be accompanied by psychotic symptoms; for example, visual hallucinations are a core feature of dementia with Lewy bodies, and delusions are often seen in Alzheimer's disease. However, for behavioral variant of frontotemporal dementia (bvFTD), studies on the broad spectrum of psychotic symptoms are still lacking. The aim of this study was to systematically and prospectively subtype the wide spectrum of psychotic symptoms in probable and definite bvFTD...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28262177/clinical-characteristics-of-patients-with-non-affective-non-organic-late-onset-psychosis
#6
Sureshkumar Ramasamy, Srikala Bharath
OBJECTIVE: Schizophrenia and related psychotic disorders are predominantly studied in young population. However some individuals do develop psychotic disorder for the first time during their old age. The aim of this study is to look at the clinical characteristics of non-affective, non-organic, late onset psychosis. PARTICIPANTS AND METHODS: Retrospective chart review study, medical records of all patients registered between 1st of January 2006 and 31st May 2011 at geriatric clinic in NIMHANS, Bangalore was screened, 83 files with a diagnosis of late onset psychosis and meeting the study criteria were systematically analyzed...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28238272/psychiatric-presentations-of-c9orf72-mutation-what-are-the-diagnostic-implications-for-clinicians
#7
Simon Ducharme, Sepideh Bajestan, Bradford C Dickerson, Valerie Voon
The C9orf72 mutation was identified as the most frequent genetic cause of frontotemporal dementia (FTD). In light of multiple reports of predominant psychiatric presentations of FTD secondary to C9orf72 mutation, the American Neuropsychiatric Association Committee on Research reviewed all studies on psychiatric aspects of this mutation to identify clinically relevant features for diagnosis. The most common psychiatric presentation is psychosis (21%-56%), with delusions, and/or multimodal hallucinations. Other presentations include late-onset mania and depression with cognitive impairment or catatonia...
February 27, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28220718/the-big-imitator-strikes-again-a-case-report-of-neurosyphilis-in-a-patient-with-newly-diagnosed-hiv
#8
Sévérine de Bruijn, Chris Kenyon, Nicolas Léonard, Erika Vlieghe
BACKGROUND: Neurosyphilis is the result of an infection of the central nervous system caused by the spirochete Treponema pallidum. Its clinical presentation includes meningovascular syphilis, tabes dorsalis, and dementia paralytica, resulting in a wide range of symptoms such as psychosis, Parkinsonism, and depression. CASE REPORT: A 49-year-old male was admitted to a psychiatric hospital because of social withdrawal and self-neglect, indicative of a major depression...
February 21, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28218226/manic-depressive-psychosis-as-the-initial-symptom-in-adult-siblings-with-late-onset-combined-methylmalonic-aciduria-and-homocystinemia-cobalamin-c-type
#9
Li-Yong Wu, Hong An, Jia Liu, Jie-Ying Li, Yue Han, Ai-Hong Zhou, Fen Wang, Jian-Ping Jia
No abstract text is available yet for this article.
February 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28095883/moderated-online-social-therapy-for-carers-of-young-people-recovering-from-first-episode-psychosis-study-protocol-for-a-randomised-controlled-trial
#10
John Gleeson, Reeva Lederman, Helen Herrman, Peter Koval, Dina Eleftheriadis, Sarah Bendall, Sue M Cotton, Mario Alvarez-Jimenez
BACKGROUND: First-episode psychosis most often has its onset during late adolescence. In caring for the young person, families endure high levels of stress and depression. Meanwhile, the social networks of families often erode. Our group has previously shown that family cognitive behaviour therapy (CBT) leads to significantly improved perceived stress compared with specialist first-episode treatment as usual; however, there are well-known barriers to the dissemination of effective family interventions...
January 17, 2017: Trials
https://www.readbyqxmd.com/read/28008202/investigation-of-single-nucleotide-variants-in-mbd5-associated-with-autism-spectrum-disorders-and-schizophrenia-phenotypes
#11
Kanako Ishizuka, Hiroki Kimura, Akira Yoshimi, Masahiro Banno, Itaru Kushima, Yota Uno, Takashi Okada, Daisuke Mori, Branko Aleksic, Norio Ozaki
MBD5 (Methyl-CpG-binding domain 5) is a critical gene for normal development. While deletion or duplication of MBD5 may contribute to a genetic predisposition to autism spectrum disorders (ASD), intellectual disability, or epilepsy, the impact of rare MBD5 single nucleotide variants (SNVs) on neurodevelopmental features, particularly features with late onset, has not been fully explored. In this study, we conducted exon-targeted resequencing of MBD5 with next-generation sequencing technology in 562 Japanese patients (192 with idiopathic ASD and 370 with schizophrenia (SCZ)) and detected 16 MBD5 SNVs with allele frequencies of ≤1%...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/27892953/thalamic-mir-338-3p-mediates-auditory-thalamocortical-disruption-and-its-late-onset-in-models-of-22q11-2-microdeletion
#12
Sungkun Chun, Fei Du, Joby J Westmoreland, Seung Baek Han, Yong-Dong Wang, Donnie Eddins, Ildar T Bayazitov, Prakash Devaraju, Jing Yu, Marcia M Mellado Lagarde, Kara Anderson, Stanislav S Zakharenko
Although 22q11.2 deletion syndrome (22q11DS) is associated with early-life behavioral abnormalities, affected individuals are also at high risk for the development of schizophrenia symptoms, including psychosis, later in life. Auditory thalamocortical (TC) projections recently emerged as a neural circuit that is specifically disrupted in mouse models of 22q11DS (hereafter referred to as 22q11DS mice), in which haploinsufficiency of the microRNA (miRNA)-processing-factor-encoding gene Dgcr8 results in the elevation of the dopamine receptor Drd2 in the auditory thalamus, an abnormal sensitivity of thalamocortical projections to antipsychotics, and an abnormal acoustic-startle response...
January 2017: Nature Medicine
https://www.readbyqxmd.com/read/27714460/late-onset-postpartum-psychoses
#13
Ian Brockington
It has been known since the eighteenth century that postpartum psychoses can begin several weeks after childbirth, not during the first fortnight. There are almost 400 non-organic episodes in the literature, starting more than 3 weeks after the birth; some of them are recurrent. The distinction of this disorder from early onset puerperal psychosis is supported by the distribution of onsets (which shows a steep fall after 14-15 days), survey data and the association with later pregnancies, not the first. Marcé believed that these late onsets were related to the resumption of menstruation...
February 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/27605254/two-distinct-patterns-of-treatment-resistance-clinical-predictors-of-treatment-resistance-in-first-episode-schizophrenia-spectrum-psychoses
#14
J Lally, O Ajnakina, M Di Forti, A Trotta, A Demjaha, A Kolliakou, V Mondelli, T Reis Marques, C Pariante, P Dazzan, S S Shergil, O D Howes, A S David, J H MacCabe, F Gaughran, R M Murray
BACKGROUND: Clozapine remains the only evidence-based antipsychotic for treatment-resistant schizophrenia (TRS). The ability to predict which patients with their first onset of schizophrenia would subsequently meet criteria for treatment resistance (TR) could help to diminish the severe functional disability which may ensue if TR is not recognized and correctly treated. METHOD: This is a 5-year longitudinal assessment of clinical outcomes in a cohort of 246 first-episode schizophrenia spectrum patients recruited as part of the NIHR Genetics and Psychosis (GAP) study conducted in South London from 2005 to 2010...
November 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27574708/late-onset-lafora-disease-with-prominent-parkinsonism-due-to-a-rare-mutation-in-epm2a
#15
David S Lynch, Nicholas W Wood, Henry Houlden
Lafora disease (LD) is an autosomal recessive form of progressive myoclonic epilepsy that is caused by mutations in EPM2A, encoding laforin, and NHLRC1 (EPM2B), encoding malin.(1) LD is classically described with onset in early teenage years. Patients develop myoclonus, epilepsy, visual hallucinations, and psychosis. Dementia is a prominent feature and often occurs in the late teenage years. LD typically progresses quickly, and patients become bedridden and dependent within 10 years of symptom onset, with life expectancy in the early 20s...
October 2016: Neurology. Genetics
https://www.readbyqxmd.com/read/27570392/does-antiepileptic-drug-withdrawal-predispose-patients-undergoing-temporal-lobe-epilepsy-surgery-to-late-onset-of-psychiatric-morbidity-a-report-of-three-cases
#16
Garima Shukla, Priya Agarwal, Rajesh Sagar, Mamta Sood, Aditya Gupta, Ashish Suri, Ajay Garg
Surgery is an established and increasingly utilized treatment option in medically refractory temporal lobe epilepsy. Many psychiatric problems are known to complicate in the postoperative period. Most studies have a follow-up period of less than 24 months. We report the cases of three patients who developed severe psychiatric problems in the late postoperative period after successful temporal lobectomy for refractory epilepsy - Psychosis, major depression with psychosis, and severe anxiety disorder, respectively...
July 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27518475/treatment-emergent-psychosis-with-disulfiram-in-a-patient-with-late-onset-alcohol-use-disorder-and-no-contributory-factors
#17
LETTER
Jaiganesh Selvapandian Thamizh, Vikas Menon, Nivedhitha Selvakumar, Ravi Philip Rajkumar
No abstract text is available yet for this article.
October 2016: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/27512585/service-and-treatment-engagement-of-people-with-very-late-onset-schizophrenia-like-psychosis
#18
Chun Chiang Sin Fai Lam, Suzanne J Reeves, Robert Stewart, Robert Howard
Aims and method Electronic patient records were used to investigate the level of engagement and treatment that patients with very late-onset schizophrenia-like psychosis (VLOSLP) had with mental health services. Results Of 131 patients assessed and diagnosed, 63 (48%) were taking antipsychotic treatment at 3 months, 46 (35%) at 6 months and 36 (27%) at 12 months. At discharge from mental health services, 54% of patients had failed to engage with services or became lost to follow-up, 18% had engaged with services but were not taking antipsychotic medication and only 28% were taking treatment...
August 2016: BJPsych Bulletin
https://www.readbyqxmd.com/read/27490935/conjoint-ftld-fus-of-the-neuronal-intermediate-filament-inclusion-disease-type-progressive-supranuclear-palsy-and-alzheimer-s-pathology-presenting-as-parkinsonism-with-early-falls-and-late-hallucinations-psychosis-and-dementia
#19
LETTER
Y Compta, O Ramos-Campoy, O Grau-Rivera, M Colom-Cadena, J Clarimón, M J Martí, E Gelpi
No abstract text is available yet for this article.
June 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27223596/schizophrenia-as-a-mimic-of-behavioral-variant-frontotemporal-dementia
#20
Cora J Kerssens, Welmoed A Krudop, Niels D Prins, Bart N M van Berckel, Annemieke Rozemuller, William W Seeley, Philip Scheltens, Max L Stek, Yolande A L Pijnenburg
Recently, the diagnostic criteria for the behavioral variant of frontotemporal dementia were revised. Although these criteria offer a relatively high sensitivity, their specificity is yet unknown. We describe a 54-year-old woman fulfilling criteria for both late-onset schizophrenia and probable behavioral variant frontotemporal dementia. Following an initial presentation with psychosis, she developed progressive apathy, compulsiveness, and executive dysfunction. Moreover, bilateral frontotemporal hypometabolism was seen on [(18)F]fludeoxyglucose-positron emission tomography...
June 2016: Neurocase
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