Sidhant Chopra, Ashlea Segal, Stuart Oldham, Alexander Holmes, Kristina Sabaroedin, Edwina R Orchard, Shona M Francey, Brian O'Donoghue, Vanessa Cropley, Barnaby Nelson, Jessica Graham, Lara Baldwin, Jeggan Tiego, Hok Pan Yuen, Kelly Allott, Mario Alvarez-Jimenez, Susy Harrigan, Ben D Fulcher, Kevin Aquino, Christos Pantelis, Stephen J Wood, Mark Bellgrove, Patrick D McGorry, Alex Fornito
IMPORTANCE: Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown. OBJECTIVE: To test the hypothesis that brain network architecture constrains cross-sectional and longitudinal gray matter alterations across different stages of psychotic illness and to identify whether certain brain regions act as putative epicenters from which volume loss spreads...
December 1, 2023: JAMA Psychiatry