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fosfomycin resistance

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https://www.readbyqxmd.com/read/28814888/frequency-of-colistin-and-fosfomycin-resistance-in-carbapenem-resistant-enterobacteriaceae-from-a-tertiary-care-hospital-in-karachi
#1
Salima Qamar, Najma Shaheen, Sadia Shakoor, Joveria Farooqi, Kauser Jabeen, Rumina Hasan
INTRODUCTION: Management of infections with carbapenem-resistant Enterobacteriaceae (CRE) is challenging. In recent times, agents such as colistin and fosfomycin have been used in combination with other antibiotics to treat such infections. In this study, we aim to seek frequency of colistin and fosfomycin resistance in CRE from Pakistan. METHODS: This study was conducted at clinical laboratories, Aga Khan University Hospital. In total, 251 CRE were included in the study...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28768448/resistance-phenotypes-and-susceptibility-of-contemporary-serratia-isolates-in-the-university-hospital-of-crete-greece
#2
George Samonis, Konstantinos Z Vardakas, Sofia Maraki, Petroula Stamouli, Viktoria-Eirini Mavromanolaki, Diamantis P Kofteridis, Matthew E Falagas
OBJECTIVE: To study changes in the susceptibility of Serratia spp. in Crete, Greece (2010-2015). METHODS: Non-duplicate isolates were examined using automated systems. Phenotypic confirmatory tests were applied. RESULTS: Three hundred and seventy-eight Serratia spp. were analyzed. Serratia marcescens (88.3%) was the predominant species. Fluoroquinolones (97.9%), carbapenems (97.4%) and fosfomycin (97.4%) were the most active followed by amikacin (95...
August 2, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28759841/a-fast-and-sensitive-lc-ms-ms-method-for-the-quantification-of-fosfomycin-in-human-urine-and-plasma-using-one-sample-preparation-method-and-hilic-chromatography
#3
Rixt A Wijma, Soma Bahmany, E B Wilms, T van Gelder, Johan W Mouton, Birgit C P Koch
Fosfomycin is an old antibiotic that is increasingly prescribed because of emergence of the antibiotic resistance and the growing incidence of multi-drug resistant infections. Surprisingly, little is known about its pharmacokinetics (PK) and the pharmacodynamics (PD). Quantification of fosfomycin in both urine and plasma provides insight into the PK/PD characteristics of fosfomycin, which is crucial for the optimization of the therapy and the prevention of the emergence of resistance. An analytical method is therefore needed for the quantification of fosfomycin in both urine and plasma...
July 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28735049/in-vitro-activity-of-daptomycin-combinations-with-rifampicin-gentamicin-fosfomycin-and-fusidic-acid-against-mrsa-strains
#4
Gulseren Aktas, Sengul Derbentli
OBJECTIVES: Although new antimicrobial agents designed to treat infections with limited therapeutic options have been introduced in the past few years, resistant Gram positive cocci have continued to emerge and spread. Daptomycin is a cyclic lipopeptide antibiotic that has rapid bactericidal activity against broad spectrum of Gram positive bacteria, including methicillin resistant Staphylococcus aureus (MRSA). Antibiotics are sometimes used in combination in an attempt to prevent or delay the in vivo emergence of drug-resistant subpopulations of pathogenic organisms...
July 19, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28734577/characterization-of-a-pvl-negative-community-acquired-methicillin-resistant-staphylococcus-aureus-strain-of-sequence-type-88-in-china
#5
Lu Sun, Dandan Wu, Yan Chen, Qian Wang, Haiping Wang, Yunsong Yu
Sequence type 88 community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) strain SR434, isolated from an outpatient with skin and soft tissue infection, was subjected to whole genome sequencing, antimicrobial susceptibility testing, mouse skin infection model and hemolysis analysis to identify its virulence and resistance determinants. MRSA strain SR434 is resistant to clindamycin, erythromycin and fosfomycin. Four plasmids with resistance genes were identified in this strain, including a 20,658bp blaZ-carrying plasmid, a 2473bp ermC-carrying plasmid, a 2622bp fosB7-carrying plasmid (86% identity with plasmid in a ST2590 MRSA strain) and a 4817bp lnuA-carrying plasmid (99% identity with pLNU4 from bovine coagulase-nagetive Staphylococci)...
July 13, 2017: International Journal of Medical Microbiology: IJMM
https://www.readbyqxmd.com/read/28727372/fosfomycin-a-good-alternative-drug-for-prostate-biopsy-prophylaxis-the-results-of-a-prospective-randomized-trial-with-respect-to-risk-factors
#6
Erdem Kisa, Mustafa Ugur Altug, Oguz Alp Gurbuz, Harun Ozdemir
PURPOSE: To determine the risk factors and the efficiency of rectal swab samples to prevent infectious complications in prostate biopsy, and compare fosfomycin with ciprofloxacin use in prophylaxis. MATERIALS AND METHODS: Between May and October 2014, pre-biopsy risk factors and their effect in ciprofloxacin and fosfomycin prophylaxis were determined. Pre-biopsy urinalysis, urine culture and rectal swab samples were obtained from all of the patients. Rectal swabs were obtained upon admission, and biopsy was performed in the following 3-7 days...
June 14, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28716360/comparison-of-synergism-between-colistin-fosfomycin-and-tigecycline-against-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-isolates-or-with-carbapenem-resistance
#7
Yee-Huang Ku, Chi-Chung Chen, Mei-Feng Lee, Yin-Ching Chuang, Hung-Jen Tang, Wen-Liang Yu
PURPOSE: To investigate the synergistic and bactericidal effects of antimicrobial combinations of any two of colistin, fosfomycin and tigecycline against the nine extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (KP) clinical isolates, including 4 carbapenem-susceptible strains and five imipenem and/or meropenem-resistant strains. METHODS: In vitro synergism and bactericidal activity of combination of colistin, fosfomycin and tigecycline were evaluated by time-kill studies in standard inoculum of bacterial densities of a suspension containing 5 × 10(5) CFU/mL by using 1/2× MIC for each alone, and both 1/2× and 1/4× MIC for any two drugs...
July 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28705769/the-plasmid-mediated-fosfomycin-resistance-determinants-and-synergy-of-fosfomycin-and-meropenem-in-carbapenem-resistant-klebsiella-pneumoniae-isolates-in-taiwan
#8
Sung-Pin Tseng, Sheng-Fan Wang, Ling Ma, Ting-Yin Wang, Tsung-Ying Yang, L Kristopher Siu, Yin-Ching Chuang, Pei-Shan Lee, Jann-Tay Wang, Tsu-Lan Wu, Jung-Chung Lin, Po-Liang Lu
BACKGROUND: Epidemiology of fosfomycin susceptibility and the plasmid-mediated fosfomycinase genes of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Taiwan remain unclear. METHODS: 642 CRKP clinical isolates were collected from a nation-wide surveillance study (16 hospitals) in Taiwan in 2012-2013. Antimicrobial susceptibilities were determined. PFGE and MLST determined the clonal relatedness. Carbapenemases and fosfomycinases genes were detected by PCR, and their flanking regions were determined by PCR and sequencing...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28694232/reinforcement-of-an-antimicrobial-stewardship-task-force-aims-at-a-better-use-of-antibiotics-of-last-resort-the-colitifos-study
#9
Benjamin Davido, Frédérique Bouchand, Aurélien Dinh, Christian Perronne, Maryvonne Villart, Olivia Senard, Jérome Salomon
BACKGROUND: Physicians are facing a worldwide increase in multidrug-resistant (MDR) organisms. Eradication of such bacteria, including so called superbugs (XDR), may cause physicians to prescribe last-resort antibiotics. However, experience with these drugs is limited and few data are available. METHODS: A before and after retrospective study was conducted from January 2008 to June 2016. Prescriptions of parenteral antimicrobials considered as last-resort antibiotics (colistin, fosfomycin, tigecycline and temocillin) were reviewed by 4 infectious disease specialists (according to microbiology results, susceptibility testing, clinical situation and alternative agents), while doses were analysed by a pharmacist...
July 8, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28688955/mechanisms-of-fosfomycin-resistance-in-carbapenem-resistant-enterobacter-spp
#10
Bryan P White, Kayla R Stover, Katie E Barber, Regina C Galloway, Donna C Sullivan, S Travis King
We report on fosfomycin susceptibility and mechanisms of resistance in clinical strains of blaKPC-positive Enterobacter sp. (n=19). 14 strains (74 %) were susceptible to fosfomycin. Nine strains were positive for fosA. No strains were positive for FosA3 or FosC2. FosA presence doesn't appear to correlate with susceptibility.
July 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28674050/plasmids-of-diverse-inc-groups-disseminate-the-fosfomycin-resistance-gene-fosa3-among-escherichia-coli-from-pigs-chickens-and-dairy-cows-in-northeast-china
#11
Xiu-Mei Wang, Zhimin Dong, Stefan Schwarz, Yao Zhu, Xin Hua, Yanhe Zhang, Siguo Liu, Wan-Jiang Zhang
Thirty-nine fosfomycin-resistant E. coli isolates carrying fosA3 were obtained from pigs, chickens, dairy cows and staff in four Northeastern provinces of China during 06/2015-04/2016. The fosA3 was co-located with blaCTX-M genes on conjugative plasmids of the incompatibility groups IncN (n=12), IncN-F33:A-:B- (n=2), IncF33:A-:B- (n=14), IncF14:A-:B- (n=2), and IncI1/ST136 (n=9). Four different genetic contexts of fosA3 were detected among the 39 E. coli isolates. Three potential epidemic plasmids circulated among E...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28670570/in-vitro-pharmacokinetics-pharmacodynamics-evaluation-of-fosfomycin-combined-with-amikacin-or-colistin-against-kpc2-producing-klebsiella-pneumoniae
#12
Wei Yu, Kai Zhou, Lihua Guo, Jinru Ji, Tianshui Niu, Tingting Xiao, Ping Shen, Yonghong Xiao
Objectives: The emergence of carbapenem-resistant Enterobacteriaceae, especially Klebsiella pneumoniae, has become a major concern in clinic settings. Combination therapy is gaining momentum to counter the secondary resistance and potential suboptimal efficacy of monotherapy. The aim of this study was to evaluate the bactericidal effect of fosfomycin (FM), amikacin (AMK), or colistin (COL) alone and combinations against KPC2-producing K. pneumoniae using dynamic model by simulating human pharmacokinetics in vitro...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28643490/characterization-of-extended-spectrum-%C3%AE-lactamase-genes-of-shigella-flexneri-isolates-with-fosfomycin-resistance-from-patients-in-china
#13
Yanyan Liu, Yue Cheng, Haifei Yang, Lifen Hu, Jun Cheng, Ying Ye, Jiabin Li
BACKGROUND: The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study was to identify fosfomycin resistance and characterize β-lactamase genes in fos-carrying isolates of Shigella flexneri from patients in China. METHODS: A total of 263 S. flexneri isolates were collected from 34 hospitals in the Anhui Province of China during September 2012-September 2015 and screened for fosA3, fosA, and fosC2 by PCR amplification and sequencing...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28631335/the-mobile-dso-gene-sso-element-in-rolling-circle-plasmids-of-staphylococci-reflects-the-evolutionary-history-of-its-resistance-gene
#14
T M Wassenaar, A Cabal
The qacC and lnuA genes of Staphylococcus species were recently proposed to comprise a mobile element when residing on rolling-circle plasmids. Here we present other examples of resistance genes on staphylococcal rolling-circle plasmids, including fosB producing resistance to fosfomycin, cat resulting in resistance to chloramphenicol and cadB for resistance to the toxic heavy metal cadmium. For three of these genes (qacC, lnuA and fosB), evidence was obtained that the genes have spread between different plasmid backgrounds...
June 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28629757/bacterial-biofilm-based-catheter-associated-urinary-tract-infections-causative-pathogens-and-antibiotic-resistance
#15
Nargis Sabir, Aamer Ikram, Gohar Zaman, Luqman Satti, Adeel Gardezi, Abeera Ahmed, Parvez Ahmed
BACKGROUND: We sought to determine the incidence of bacterial biofilm-based catheter-associated urinary tract infections, identify variables affecting biofilm formation, and identify etiologic bacterial pathogens and antibiotic-resistance patterns associated with biofilm-based catheter-associated urinary tract infections (CAUTIs) in our setup. METHODS: Patients who developed at least 2 symptoms of urinary tract infection after at least 2 days of indwelling urinary catheters were included...
June 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28625025/-causative-bacterial-strains-and-sensitivityto-antimicrobial-agents-in-female-acute-uncomplicated-cystitis
#16
Takuya Owari, Tomoki Yamamoto, Shinichiro Mizobuchi, Yositaka Itami, Tomonori Nakahama, Yosihiro Matsumoto, Kaoru Yamada, Hitoshi Momose
Recently, wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection. To investigate the causative bacterial strains of female acute uncomplicated cystitis (AUC) in the community and their sensitivity to antimicrobial agents, we retrospectively reviewed the medical records of 215 female AUC patients treated at our clinics from April 2014 to June 2015. Two hundred and nineteen strains were isolated as the causative bacteria from the patients'urine samples, including E...
May 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28616818/fosfomycin-for-the-treatment-of-drug-resistant-urinary-tract-infections-potential-of-an-old-drug-not-explored-fully
#17
Vrushali Patwardhan, Sarman Singh
INTRODUCTION: Increased emergence of bacterial resistance and the limited options of novel antimicrobial agents have necessitated the reintroduction of some old antimicrobial agents. One such drug is fosfomycin, but its potential has not been explored fully, especially in India. AIMS AND OBJECTIVES: To analyze the in vitro activity of fosfomycin, against the urinary isolates and to compare it with in vitro activity of other orally administered antimicrobial agents...
June 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28612692/-fosfomycin-an-old-antibiotic-with-new-possibilities
#18
A C Dijkmans, S G Kuiper, J Burggraaf, J W Mouton, E B Wilms, D J Touw, J Stevens, C van Nieuwkoop, I M C Kamerling
- Fosfomycin is a broad-spectrum antibiotic agent used orally for uncomplicated cystitis. The intravenous form of administration has recently been authorised in the Netherlands.- Thanks to its broad spectrum and extensive tissue penetration, fosfomycin offers possibilities for the treatment of infections in different organs.- Infections with multidrug-resistant bacteria pose a significant threat to public health. Many of these multidrug-resistant bacteria are sensitive to fosfomycin, which means fosfomycin may be an option for the treatment of infections with multidrug-resistant bacteria...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28607025/pharmacodynamic-evaluation-of-fosfomycin-against-escherichia-coli-and-klebsiella-spp-from-urinary-tract-infections-and-the-influence-of-ph-on-fosfomycin-activities
#19
Nayara Helisandra Fedrigo, Josmar Mazucheli, James Albiero, Danielle Rosani Shinohara, Fernanda Gomes Lodi, Ana Cristina Dos Santos Machado, Sherwin K B Sy, Maria Cristina Bronharo Tognim
Fosfomycin is widely used for the treatment of uncomplicated urinary tract infection (UTI), and it has recently been recommended that fosfomycin be used to treat infections caused by multidrug-resistant (MDR) Gram-negative bacilli. Whether urine acidification can improve bacterial susceptibility to fosfomycin oral dosing regimens has not been analyzed. The MIC of fosfomycin for 245 Gram-negative bacterial isolates, consisting of 158 Escherichia coli isolates and 87 Klebsiella isolates which were collected from patients with urinary tract infections, were determined at pH 6...
August 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28588223/d-cycloserine-increases-the-effectiveness-of-vancomycin-against-vancomycin-highly-resistant-staphylococcus-aureus
#20
COMPARATIVE STUDY
Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya, Kazuhisa Sekimizu
Vancomycin is a widely used clinical drug to treat for infection by methicillin-resistant Staphylococcus aureus. Some patients show a weak response to vancomycin treatment. We previously reported that β-lactams increase the susceptibility to vancomycin by vancomycin-highly resistant S. aureus (VRSA) strains obtained following repeated in vitro mutagenesis and vancomycin selection. Here we found that the susceptibility of the VRSA strains to vancomycin was remarkably increased by combined treatment with D-cycloserine...
July 2017: Journal of Antibiotics
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