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fosfomycin resistance

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https://www.readbyqxmd.com/read/28716360/comparison-of-synergism-between-colistin-fosfomycin-and-tigecycline-against-extended-spectrum-%C3%AE-lactamase-producing-klebsiella-pneumoniae-isolates-or-with-carbapenem-resistance
#1
Yee-Huang Ku, Chi-Chung Chen, Mei-Feng Lee, Yin-Ching Chuang, Hung-Jen Tang, Wen-Liang Yu
PURPOSE: To investigate the synergistic and bactericidal effects of antimicrobial combinations of any two of colistin, fosfomycin and tigecycline against the nine extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (KP) clinical isolates, including 4 carbapenem-susceptible strains and five imipenem and/or meropenem-resistant strains. METHODS: In vitro synergism and bactericidal activity of combination of colistin, fosfomycin and tigecycline were evaluated by time-kill studies in standard inoculum of bacterial densities of a suspension containing 5 × 10(5) CFU/mL by using 1/2× MIC for each alone, and both 1/2× and 1/4× MIC for any two drugs...
July 6, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28705769/the-plasmid-mediated-fosfomycin-resistance-determinants-and-synergy-of-fosfomycin-and-meropenem-in-carbapenem-resistant-klebsiella-pneumoniae-isolates-in-taiwan
#2
Sung-Pin Tseng, Sheng-Fan Wang, Ling Ma, Ting-Yin Wang, Tsung-Ying Yang, L Kristopher Siu, Yin-Ching Chuang, Pei-Shan Lee, Jann-Tay Wang, Tsu-Lan Wu, Jung-Chung Lin, Po-Liang Lu
BACKGROUND: Epidemiology of fosfomycin susceptibility and the plasmid-mediated fosfomycinase genes of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Taiwan remain unclear. METHODS: 642 CRKP clinical isolates were collected from a nation-wide surveillance study (16 hospitals) in Taiwan in 2012-2013. Antimicrobial susceptibilities were determined. PFGE and MLST determined the clonal relatedness. Carbapenemases and fosfomycinases genes were detected by PCR, and their flanking regions were determined by PCR and sequencing...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28694232/reinforcement-of-an-antimicrobial-stewardship-task-force-aims-at-a-better-use-of-antibiotics-of-last-resort-the-colitifos-study
#3
Benjamin Davido, Frédérique Bouchand, Aurélien Dinh, Christian Perronne, Maryvonne Villart, Olivia Senard, Jérome Salomon
BACKGROUND: Physicians are facing a worldwide increase in multidrug-resistant (MDR) organisms. Eradication of such bacteria, including so called superbugs (XDR), may cause physicians to prescribe last-resort antibiotics. However, experience with these drugs is limited and few data are available. METHODS: A before and after retrospective study was conducted from January 2008 to June 2016. Prescriptions of parenteral antimicrobials considered as last-resort antibiotics (colistin, fosfomycin, tigecycline and temocillin) were reviewed by 4 infectious disease specialists (according to microbiology results, susceptibility testing, clinical situation and alternative agents), while doses were analyzed by a pharmacist...
July 7, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28688955/mechanisms-of-fosfomycin-resistance-in-carbapenem-resistant-enterobacter-spp
#4
Bryan P White, Kayla R Stover, Katie E Barber, Regina C Galloway, Donna C Sullivan, S Travis King
We report on fosfomycin susceptibility and mechanisms of resistance in clinical strains of blaKPC-positive Enterobacter sp. (n=19). 14 strains (74 %) were susceptible to fosfomycin. Nine strains were positive for fosA. No strains were positive for FosA3 or FosC2. FosA presence doesn't appear to correlate with susceptibility.
July 5, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28674050/plasmids-of-diverse-inc-groups-disseminate-the-fosfomycin-resistance-gene-fosa3-among-escherichia-coli-from-pigs-chickens-and-dairy-cows-in-northeast-china
#5
Xiu-Mei Wang, Zhimin Dong, Stefan Schwarz, Yao Zhu, Xin Hua, Yanhe Zhang, Siguo Liu, Wan-Jiang Zhang
Thirty-nine fosfomycin-resistant E. coli isolates carrying fosA3 were obtained from pigs, chickens, dairy cows and staff in four Northeastern provinces of China during 06/2015-04/2016. The fosA3 was co-located with blaCTX-M genes on conjugative plasmids of the incompatibility groups IncN (n=12), IncN-F33:A-:B- (n=2), IncF33:A-:B- (n=14), IncF14:A-:B- (n=2), and IncI1/ST136 (n=9). Four different genetic contexts of fosA3 were detected among the 39 E. coli isolates. Three potential epidemic plasmids circulated among E...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28670570/in-vitro-pharmacokinetics-pharmacodynamics-evaluation-of-fosfomycin-combined-with-amikacin-or-colistin-against-kpc2-producing-klebsiella-pneumoniae
#6
Wei Yu, Kai Zhou, Lihua Guo, Jinru Ji, Tianshui Niu, Tingting Xiao, Ping Shen, Yonghong Xiao
Objectives: The emergence of carbapenem-resistant Enterobacteriaceae, especially Klebsiella pneumoniae, has become a major concern in clinic settings. Combination therapy is gaining momentum to counter the secondary resistance and potential suboptimal efficacy of monotherapy. The aim of this study was to evaluate the bactericidal effect of fosfomycin (FM), amikacin (AMK), or colistin (COL) alone and combinations against KPC2-producing K. pneumoniae using dynamic model by simulating human pharmacokinetics in vitro...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28643490/characterization-of-extended-spectrum-%C3%AE-lactamase-genes-of-shigella-flexneri-isolates-with-fosfomycin-resistance-from-patients-in-china
#7
Yanyan Liu, Yue Cheng, Haifei Yang, Lifen Hu, Jun Cheng, Ying Ye, Jiabin Li
BACKGROUND: The emergence of fosfomycin resistance and extended-spectrum β-lactamase (ESBL) genes is a serious threat to public health and a new challenge in shigellosis treatment. The purpose of this study was to identify fosfomycin resistance and characterize β-lactamase genes in fos-carrying isolates of Shigella flexneri from patients in China. METHODS: A total of 263 S. flexneri isolates were collected from 34 hospitals in the Anhui Province of China during September 2012-September 2015 and screened for fosA3, fosA, and fosC2 by PCR amplification and sequencing...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28631335/the-mobile-dso-gene-sso-element-in-rolling-circles-plasmids-of-staphylococci-reflects-the-evolutionary-history-of-its-resistance-gene
#8
Trudy M Wassenaar, Adriana Cabal
The qacC and lnuA genes of Staphylococcus species were recently proposed to comprise a mobile element when residing on rolling-circle plasmids. Here we present other examples of resistance genes on staphylococcal rolling-circle plasmids, including fosB producing resistance to fosfomycin, cat resulting in resistance to chloramphenicol, and cadB for resistance to the toxic heavy metal cadmium. For three of these genes (qacC, lnuA and fosB) evidence was obtained that the genes have spread between different plasmid backgrounds...
June 20, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28629757/bacterial-biofilm-based-catheter-associated-urinary-tract-infections-causative-pathogens-and-antibiotic-resistance
#9
Nargis Sabir, Aamer Ikram, Gohar Zaman, Luqman Satti, Adeel Gardezi, Abeera Ahmed, Parvez Ahmed
BACKGROUND: We sought to determine the incidence of bacterial biofilm-based catheter-associated urinary tract infections, identify variables affecting biofilm formation, and identify etiologic bacterial pathogens and antibiotic-resistance patterns associated with biofilm-based catheter-associated urinary tract infections (CAUTIs) in our setup. METHODS: Patients who developed at least 2 symptoms of urinary tract infection after at least 2 days of indwelling urinary catheters were included...
June 16, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28625025/-causative-bacterial-strains-and-sensitivityto-antimicrobial-agents-in-female-acute-uncomplicated-cystitis
#10
Takuya Owari, Tomoki Yamamoto, Shinichiro Mizobuchi, Yositaka Itami, Tomonori Nakahama, Yosihiro Matsumoto, Kaoru Yamada, Hitoshi Momose
Recently, wide spreading of fluoloquinolone resistant Escherichia coli is a serious problem inthe treatment of urinary tract infection. To investigate the causative bacterial strains of female acute uncomplicated cystitis (AUC) in the community and their sensitivity to antimicrobial agents, we retrospectively reviewed the medical records of 215 female AUC patients treated at our clinics from April 2014 to June 2015. Two hundred and nineteen strains were isolated as the causative bacteria from the patients'urine samples, including E...
May 2017: Hinyokika Kiyo. Acta Urologica Japonica
https://www.readbyqxmd.com/read/28616818/fosfomycin-for-the-treatment-of-drug-resistant-urinary-tract-infections-potential-of-an-old-drug-not-explored-fully
#11
Vrushali Patwardhan, Sarman Singh
INTRODUCTION: Increased emergence of bacterial resistance and the limited options of novel antimicrobial agents have necessitated the reintroduction of some old antimicrobial agents. One such drug is fosfomycin, but its potential has not been explored fully, especially in India. AIMS AND OBJECTIVES: To analyze the in vitro activity of fosfomycin, against the urinary isolates and to compare it with in vitro activity of other orally administered antimicrobial agents...
June 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28612692/-fosfomycin-an-old-antibiotic-with-new-possibilities
#12
A C Dijkmans, S G Kuiper, J Burggraaf, J W Mouton, E B Wilms, D J Touw, J Stevens, C van Nieuwkoop, I M C Kamerling
- Fosfomycin is a broad-spectrum antibiotic agent used orally for uncomplicated cystitis. The intravenous form of administration has recently been authorised in the Netherlands.- Thanks to its broad spectrum and extensive tissue penetration, fosfomycin offers possibilities for the treatment of infections in different organs.- Infections with multidrug-resistant bacteria pose a significant threat to public health. Many of these multidrug-resistant bacteria are sensitive to fosfomycin, which means fosfomycin may be an option for the treatment of infections with multidrug-resistant bacteria...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28607025/pharmacodynamic-evaluation-of-fosfomycin-against-e-coli-and-klebsiella-spp-from-urinary-tract-infections-and-the-influence-of-ph-on-fosfomycin-activities
#13
Nayara Helisandra Fedrigo, Josmar Mazucheli, James Albiero, Danielle Rosani Shinohara, Fernanda Gomes Lodi, Ana Cristina Dos Santos Machado, Sherwin K B Sy, Maria Cristina Bronharo Tognim
Fosfomycin is widely used for the treatment of uncomplicated urinary tract infection (UTI) and recently have been recommended for treating multidrug-resistant (MDR) gram-negative bacilli. Whether urine acidification can improve bacterial susceptibility to fosfomycin oral dosing regimen has not been analyzed. Minimal inhibitory concentration (MIC) was determined using agar dilution in pH 6.0 and 7.0 for 245 Gram negative bacterial isolates, consisting of 158 E. coli and 87 Klebsiella spp. which were collected from patients with UTI...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28588223/d-cycloserine-increases-the-effectiveness-of-vancomycin-against-vancomycin-highly-resistant-staphylococcus-aureus
#14
Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya, Kazuhisa Sekimizu
Vancomycin is a widely used clinical drug to treat for infection by methicillin-resistant Staphylococcus aureus. Some patients show a weak response to vancomycin treatment. We previously reported that β-lactams increase the susceptibility to vancomycin by vancomycin-highly resistant S. aureus (VRSA) strains obtained following repeated in vitro mutagenesis and vancomycin selection. Here we found that the susceptibility of the VRSA strains to vancomycin was remarkably increased by combined treatment with D-cycloserine...
June 7, 2017: Journal of Antibiotics
https://www.readbyqxmd.com/read/28584435/a-study-of-24-patients-with-colistin-resistant-gram-negative-isolates-in-a-tertiary-care-hospital-in-south-india
#15
Rajalakshmi Arjun, Ram Gopalakrishnan, P Senthur Nambi, D Suresh Kumar, R Madhumitha, V Ramasubramanian
BACKGROUND: As the use of colistin to treat carbapenem-resistant Gram-negative infections increases, colistin resistance is being increasingly reported in Indian hospitals. MATERIALS AND METHODS: Retrospective chart review of clinical data from patients with colistin-resistant isolates (minimum inhibitory concentration >2 mcg/ml). Clinical profile, outcome, and antibiotics that were used for treatment were analyzed. RESULTS: Twenty-four colistin-resistant isolates were reported over 18 months (January 2014-June 2015)...
May 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28579984/mutations-of-the-transporter-proteins-glpt-and-uhpt-confer-fosfomycin-resistance-in-staphylococcus-aureus
#16
Su Xu, Zhuyingjie Fu, Ying Zhou, Yang Liu, Xiaogang Xu, Minggui Wang
With the increasing spread of methicillin-resistant Staphylococcus aureus worldwide, fosfomycin has begun to be used more often, either alone or in combination with other antibiotics, for treating methicillin-resistant S. aureus infections, resulting in the emergence of fosfomycin-resistant strains. Fosfomycin resistance is reported to be mediated by fosfomycin-modifying enzymes (FosA, FosB, FosC, and FosX) and mutations of the target enzyme MurA or the membrane transporter proteins UhpT and GlpT. Our previous studies indicated that the fos genes might not the major fosfomycin resistance mechanism in S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28577932/in-vitro-activity-of-several-antimicrobial-agents-against-methicillin-resistant-staphylococcus-aureus-mrsa-isolates-expressing-aminoglycoside-modifying-enzymes-potency-of-plazomicin-alone-and-in-combination-with-other-agents
#17
María Carmen López-Díaz, Esther Ríos, Iciar Rodríguez-Avial, Rosa Janneth Simaluiza, Juan José Picazo, Esther Culebras
This study investigated the in-vitro activity of clinically relevant aminoglycosides and new antimicrobial agents - plazomicin, ceftobiprole and dalbavancin - against 55 methicillin-resistant Staphylococcus aureus (MRSA) isolates producing aminoglycoside-modifying enzymes (AMEs). The checkerboard method was used to assess synergism between plazomicin and four antibiotics (fosfomycin, ceftobiprole, cefoxitin and meropenem), and time-kill assays were performed for the most active combinations. Among the aminoglycosides tested, plazomicin was the most active agent against MRSA, with >90% of isolates being inhibited at a minimum inhibitory concentration (MIC) of ≤1 mg/L...
May 31, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28540747/in-vitro-susceptibility-and-resistance-phenotypes-in-contemporary-enterobacter-isolates-in-a-university-hospital-in-crete-greece
#18
Sofia Maraki, Konstantinos Z Vardakas, George Samonis, Dimitrios Perdikis, Viktoria Eirini Mavromanolaki, Diamantis P Kofteridis, Matthew E Falagas
AIM: To study the evolution in the susceptibility of Enterobacter spp. in Crete, Greece from 2010 to 2015. METHODS: Non-duplicate isolates were studied using automated systems. Phenotypic confirmatory tests were applied. RESULTS: A total of 939 Enterobacter isolates were included. Colistin was the most active antibiotic (97.9%) followed by imipenem (96.1%), gentamicin (95.7%), tigecycline (91.8%), cefepime (89.4%), chloramphenicol (85.8%), fosfomycin (85...
May 25, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28537050/prevalence-and-significance-of-fluoroquinolone-resistant-bacteria-carriage-in-patients-undergoing-transrectal-ultrasound-prostate-biopsy
#19
Amir Hasanzadeh, Mohammad Reza Pourmand, Ahad Alizadeh, Gholamreza Pourmand
PURPOSE: To determine the prevalence of fluoroquinolone-resistant (FQR) bacteria carriage in patients undergoing transrectal ultrasound prostate biopsy (TRUS-Bx), and the relationship between the risk factors and FQR carriers as well as infections after prostate biopsy. MATERIALS AND METHODS: Rectal swabs were obtained from 158 patients undergoing TRUS-Bx. The FQR organisms were isolated using selective media, and the antibiotic susceptibility pattern was determined...
May 23, 2017: Urology Journal
https://www.readbyqxmd.com/read/28533247/first-detection-of-a-fosfomycin-resistance-gene-fosa7-in-salmonella-enterica-serovar-heidelberg-isolated-from-broiler-chickens
#20
Muhammad A Rehman, Xianhua Yin, Marissa G Persaud-Lachhman, Moussa S Diarra
We previously described Salmonella Heidelberg harbouring a chromosomal gene cluster similar to the glutathione S-transferase gene, a putative fosA conferring resistance to fosfomycin. Here we show that this new gene named fosA7 confers resistance to fosfomycin. Introduction of fosA7 into fosfomycin susceptible Salmonella Enteritidis, resulted in a substantial increase in the fosfomycin MIC. This finding increases awareness of antibiotic resistance in Salmonella Heidelberg from broiler related to the food safety and public health...
May 22, 2017: Antimicrobial Agents and Chemotherapy
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