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fosfomycin resistance

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https://www.readbyqxmd.com/read/29769010/evaluation-of-fosfomycin-activity-against-esbl-producing-enterobacteriaceae-isolated-from-iran
#1
Hossein Kazemian
BACKGROUND: Rising rates of antimicrobial resistance among Enterobacteriaceae limit the use of reliably active forms of available drugs. The aim of this study was to investigate the prevalence of fosfomycin (US6794490B2) resistance gene among ESBL producing isolates in Iran. METHOD: We tested 355 isolates of Enterobacteriacea collected from various clinical samples including urine, wounds, blood and other sources during June 2016 to July 2017. Antibiotic sensitivity and extended spectrum beta lactamase (ESBL) production were tested using agar dilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines...
May 16, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29763630/clinical-and-molecular-epidemiologic-characteristics-of-carbapenem-resistant-klebsiella-pneumoniae-infection-colonization-among-neonates-in-china
#2
Dandan Yin, Lei Zhang, Aimin Wang, Leiyan He, Yun Cao, Fupin Hu, Chuanqing Wang
BACKGROUND: The spread of carbapenem-resistant Klebsiella pneumoniae (CR-KPN) is a major concern, but data on CR-KPN infection/colonization in paediatric populations are limited. AIM: This study aimed to analyze epidemiologic and clinical characteristics, therapeutic options of CR-KPN infections in neonates in China. METHODS: A retrospective study was performed at the Children's Hospital of Fudan University, including 88 neonates with CR-KPN admitted between November 2015 and October 2016...
May 12, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29740989/activity-of-fosfomycin-against-nosocomial-multiresistant-bacterial-pathogens-from-croatia-a-multicentric-study
#3
Luka Bielen, Robert Likić, Viktorija Erdeljić, Ivana Mareković, Nataša Firis, Marijana Grgić-Medić, Ana Godan, Ivan Tomić, Blaženka Hunjak, Alemka Markotić, Danijela Bejuk, Vladimira Tičić, Silvana Balzar, Branka Bedenić
AIM: To determine in vitro susceptibility of multiresistant bacterial isolates to fosfomycin. METHODS: In this prospective in vitro study (local non-random sample, level of evidence 3), 288 consecutively collected multiresistant bacterial isolates from seven medical centers in Croatia were tested from February 2014 until October 2016 for susceptibility to fosfomycin and other antibiotics according to Clinical and Laboratory Standards Institute methodology. Susceptibility to fosfomycin was determined by agar dilution method, while disc diffusion was performed for in vitro testing of other antibiotics...
April 30, 2018: Croatian Medical Journal
https://www.readbyqxmd.com/read/29731646/in-vitro-antibacterial-effect-of-fosfomycin-combination-therapy-against-colistin-resistant-klebsiella-pneumoniae
#4
Wei Yu, Qixia Luo, Qingyi Shi, Chen Huang, Xiao Yu, Tianshui Niu, Kai Zhou, Jiajie Zhang, Yonghong Xiao
Objectives: Colistin is still a "last-resort" antibiotic used to manage human infections due to multidrug-resistant (MDR) Klebsiella pneumoniae . However, colistin-resistant K. pneumoniae (CR-Kp) isolates emerged a decade ago and had a worldwide distribution. The purpose of this study was to evaluate the genetic data of CR-Kp and identify the antibacterial activity of fosfomycin (FM) alone and in combination with amikacin (AMK) or colistin (COL) against CR-Kp in vitro. Methods: Three clinical CR-Kp isolates from three patients were collected...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29730830/the-epidemiology-evolution-and-treatment-of-kpc-producing-organisms
#5
REVIEW
Ann Marie Porreca, Kaede V Sullivan, Jason C Gallagher
PURPOSE OF REVIEW: The purpose of this review is to investigate the evolution and epidemiology of Klebsiella pneumoniae carbapenemase (KPC)-producing organisms and the current and future treatment options for infections caused by KPC-producing isolates. RECENT FINDINGS: The emergence of resistance in Enterobacteriaceae producing carbapenemases globally has increased the challenges in treating infections caused by these organisms. One of the prominent mechanisms of resistance is the production of KPC enzymes...
May 5, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29710295/effect-of-5-day-nitrofurantoin-vs-single-dose-fosfomycin-on-clinical-resolution-of-uncomplicated-lower-urinary-tract-infection-in-women-a-randomized-clinical-trial
#6
Angela Huttner, Anna Kowalczyk, Adi Turjeman, Tanya Babich, Caroline Brossier, Noa Eliakim-Raz, Katarzyna Kosiek, Begoña Martinez de Tejada, Xavier Roux, Shachaf Shiber, Ursula Theuretzbacher, Elodie von Dach, Dafna Yahav, Leonard Leibovici, Maciek Godycki-Cwirko, Johan W Mouton, Stephan Harbarth
Importance: The use of nitrofurantoin and fosfomycin has increased since guidelines began recommending them as first-line therapy for lower urinary tract infection (UTI). Objective: To compare the clinical and microbiologic efficacy of nitrofurantoin and fosfomycin in women with uncomplicated cystitis. Design, Setting, and Participants: Multinational, open-label, analyst-blinded, randomized clinical trial including 513 nonpregnant women aged 18 years and older with symptoms of lower UTI (dysuria, urgency, frequency, or suprapubic tenderness), a positive urine dipstick result (with detection of nitrites or leukocyte esterase), and no known colonization or previous infection with uropathogens resistant to the study antibiotics...
May 1, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29709971/prevalence-of-fosfomycin-resistance-in-methicillin-resistant-staphylococcus-aureus-isolated-from-patients-in-a-university-hospital-in-china-2013-2015
#7
Dandan Wu, Yan Chen, Lu Sun, Tingting Qu, Haiping Wang, Yunsong Yu
We aimed to investigate the fosfomycin susceptibility among different methicillin-resistant Staphylococcus aureus (MRSA) clones. Total 293 MRSA isolates obtained from Sir Run Run Shaw hospital during 2013~2015 were tested for fosfomycin susceptibility. The overall fosfomycin resistance rate among these MRSA isolates was 53.2%. For ST5 MRSA isolates (MIC50 >1024mg/L), 91.9% isolates were resistant to fosfomycin. No fosfomycin-resistant isolate was found among the 69 ST59 MRSA isolates (MIC50/90, 0.5/4 mg/L)...
April 27, 2018: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29693543/urinary-tract-infection-by-acinetobacter-baumannii-and-pseudomonas-aeruginosa-evolution-of-antimicrobial-resistance-and-therapeutic-alternatives
#8
Gemma Jiménez-Guerra, Victor Heras-Cañas, Miguel Gutiérrez-Soto, María Del Pilar Aznarte-Padial, Manuela Expósito-Ruiz, José María Navarro-Marí, José Gutiérrez-Fernández
PURPOSE: Acinetobacter baumannii and Pseudomonas aeruginosa are responsible for numerous nosocomial infections. The objective of this study was to determine the development of their susceptibility to ten antibiotics and the antibiotic consumption of patients with suspicion of urinary tract infection (UTI). METHODOLOGY: A retrospective study was conducted on the susceptibility profiles of A. baumannii and P. aeruginosa isolates from 749 urine samples gathered between January 2013 and December 2016, and on the consumption of imipenem, meropenem and piperacillin-tazobactam between 2014 and 2016...
April 25, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29675117/adherence-to-international-guidelines-for-the-treatment-of-uncomplicated-urinary-tract-infections-in-lebanon
#9
Wissam K Kabbara, Mohamad M Meski, Wijdan H Ramadan, Dina S Maaliki, Pascale Salameh
Objective: The purpose of this study is to evaluate antibiotic-prescribing practices and adherence to IDSA guidelines for the treatment of uncomplicated urinary tract infections in Lebanon. Methods: This observational prospective study was conducted in 15 community pharmacies in Lebanon over 1 year in adult females. A regimen of nitrofurantoin 100 mg bid for 5 days or fosfomycin 3 grams single dose were considered appropriate. For the bivariate analysis, the chi-square test was used...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29669887/pseudomonas-aeruginosa-gsha-mutant-is-defective-in-biofilm-formation-swarming-and-pyocyanin-production
#10
Tricia A Van Laar, Saika Esani, Tyler J Birges, Bethany Hazen, Jason M Thomas, Mamta Rawat
Pseudomonas aeruginosa is a ubiquitous Gram-negative bacterium that can cause severe opportunistic infections. The principal redox buffer employed by this organism is glutathione (GSH). To assess the role of GSH in the virulence of P. aeruginosa , a number of analyses were performed using a mutant strain deficient in gshA , which does not produce GSH. The mutant strain exhibited a growth delay in minimal medium compared to the wild-type strain. Furthermore, the gshA mutant was defective in biofilm and persister cell formation and in swimming and swarming motility and produced reduced levels of pyocyanin, a key virulence factor...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29666664/oral-fosfomycin-for-the-treatment-of-acute-and-chronic-bacterial-prostatitis-caused-by-multidrug-resistant-escherichia-coli
#11
REVIEW
George G Zhanel, Michael A Zhanel, James A Karlowsky
Acute and chronic bacterial prostatitis in outpatients is commonly treated with oral fluoroquinolones; however, the worldwide dissemination of multidrug-resistant (MDR) Escherichia coli has resulted in therapeutic failures with fluoroquinolones. We reviewed the literature regarding the use of oral fosfomycin in the treatment of acute and chronic prostatitis caused by MDR E. coli . All English-language references on PubMed from 1986 to June 2017, inclusive, were reviewed from the search "fosfomycin prostatitis...
2018: Canadian Journal of Infectious Diseases & Medical Microbiology
https://www.readbyqxmd.com/read/29661874/characterization-of-extensively-or-pandrug-resistant-st147-and-st101-oxa-48-producing-klebsiella-pneumoniae-isolates-causing-bloodstream-infections-in-icu-patients
#12
Kalliope Avgoulea, Vincenzo Di Pilato, Olympia Zarkotou, Samanta Sennati, Leda Politi, Antonio Cannatelli, Katerina Themeli-Digalaki, Tommaso Giani, Athanassios Tsakris, Gian Maria Rossolini, Spyros Pournaras
Carbapenem-resistant Klebsiella pneumoniae cause important healthcare-associated infections worldwide. An outbreak of ST11 OXA-48-producing K. pneumoniae isolates (OXA-48-Kp) occurred in Tzaneio Hospital in 2012 and was contained until 2014, when OXA-48-Kp reemerged. The present study involved 19 bloodstream infection (BSI) OXA-48-Kp recovered from 19 ICU patients hospitalized between August 2014 and July 2016. MICs were determined by broth microdilution. β-lactamase genes were detected by PCR. All isolates were typed by PFGE/MLST and 10 representative isolates by next generation sequencing (NGS)...
April 16, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29660401/intravenous-fosfomycin-for-pulmonary-exacerbation-of-cystic-fibrosis-real-life-experience-of-a-large-adult-cf-centre
#13
G Spoletini, M Kennedy, L Flint, T Graham, C Etherington, N Shaw, P Whitaker, M Denton, I Clifton, D Peckham
BACKGROUND: The increased prevalence of multi-drug resistant strains of P.aeruginosa and allergic reactions among adult patients with cystic fibrosis (CF) limits the number of antibiotics available to treat pulmonary exacerbations. Fosfomycin, a unique broad spectrum bactericidal antibiotic, might offer an alternative therapeutic option in such cases. AIM: To describe the clinical efficacy, safety and tolerability of intravenous fosfomycin in combination with a second anti-pseudomonal antibiotic to treat pulmonary exacerbations in adult patients with CF...
April 13, 2018: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29649596/population-pharmacokinetics-and-pharmacodynamics-of-fosfomycin-in-non-critically-ill-patients-with-bacteremic-urinary-infection-caused-by-multidrug-resistant-escherichia-coli
#14
Vicente Merino-Bohorquez, Fernando Docobo-Pérez, Jesús Sojo, Isabel Morales, Carmen Lupión, Dolores Martín, Manuel Cameán, William Hope, Álvaro Pascual, Jesús Rodríguez-Baño
The aim of the present study was to describe the population pharmacokinetics of fosfomycin for patients with bacteraemic urinary tract infection (B-UTI). The analysis identified optimal regimens, based on pharmacodynamic targets and assessed the adequacy of CLSI and EUCAST susceptibility breakpoints for Escherchia coli. MethodsSixteen patients with B-UTI caused by multidrug-resistant E. coli, (FOREST clinical trial) received intravenous fosfomycin (4g/Q6h) were analysed. A population pharmacokinetic analysis was performed, and Monte Carlo simulations were undertaken using 4g/Q6h or 8g/Q8h...
April 9, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29643424/poultry-hatcheries-as-potential-reservoirs-for-antimicrobial-resistant-escherichia-coli-a-risk-to-public-health-and-food-safety
#15
Kamelia M Osman, Anthony D Kappell, Mohamed Elhadidy, Fatma ElMougy, Wafaa A Abd El-Ghany, Ahmed Orabi, Aymen S Mubarak, Turki M Dawoud, Hassan A Hemeg, Ihab M I Moussa, Ashgan M Hessain, Hend M Y Yousef
Hatcheries have the power to spread antimicrobial resistant (AMR) pathogens through the poultry value chain because of their central position in the poultry production chain. Currently, no information is available about the presence of AMR Escherichia coli strains and the antibiotic resistance genes (ARGs) they harbor within hatchezries. Therefore, this study aimed to investigate the possible involvement of hatcheries in harboring hemolytic AMR E. coli. Serotyping of the 65 isolated hemolytic E. coli revealed 15 serotypes with the ability to produce moderate biofilms, and shared susceptibility to cephradine and fosfomycin and resistance to spectinomycin...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29623443/pharmacokinetic-and-pharmacodynamic-considerations-of-antibiotics-of-last-resort-in-treating-gram-negative-infections-in-adult-critically-ill-patients
#16
REVIEW
Mojdeh S Heavner, Kimberly C Claeys, Anne M Masich, Jeffrey P Gonzales
PURPOSE OF REVIEW: We provide an overview of antimicrobials that are considered last resort for the treatment of resistant gram-negative infections in adult critically ill patients. The role in therapy, pharmacodynamic (PD) goals, and pharmacokinetic (PK) changes in critical illness for aminoglycosides, polymyxins, tigecycline, fosfomycin, and fluoroquinolones are summarized. RECENT FINDINGS: Altered PK in septic patients in the intensive care unit (ICU) is observed with many of our agents of last resort...
April 5, 2018: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/29615988/parallel-evolution-of-high-level-aminoglycoside-resistance-in-escherichia-coli-under-low-and-high-mutation-supply-rates
#17
Claudia Ibacache-Quiroga, Juan C Oliveros, Alejandro Couce, Jesus Blázquez
Antibiotic resistance is a major concern in public health worldwide, thus there is much interest in characterizing the mutational pathways through which susceptible bacteria evolve resistance. Here we use experimental evolution to explore the mutational pathways toward aminoglycoside resistance, using gentamicin as a model, under low and high mutation supply rates. Our results show that both normo and hypermutable strains of Escherichia coli are able to develop resistance to drug dosages > 1,000-fold higher than the minimal inhibitory concentration for their ancestors...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29615256/f14-a-b-and-incx4-inc-group-cfr-positive-plasmids-circulating-in-escherichia-coli-of-animal-origin-in-northeast-china
#18
Xiumei Wang, Yao Zhu, Xin Hua, Fuguang Chen, Changzhen Wang, Yanhe Zhang, Siguo Liu, Wanjiang Zhang
The objective of this study was to investigate the prevalence of the cfr gene in Escherichia coli isolates from domestic animals in Northeast China and to characterize the cfr-containing plasmids. Between June 2015 and April 2016, 370 E. coli isolates were collected from pigs, chickens, and dairy cows in Northeast China. Among these, 111 were florfenicol resistant, including 109 isolates carrying the floR gene and 6 positives for cfr. The prevalence of cfr in E. coli isolates from the four northeast provinces in China was 1...
April 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29610194/the-combination-of-daptomycin-plus-fosfomycin-has-synergistic-potent-and-rapid-bactericidal-activity-against-methicillin-resistant-staphylococcus-aureus-mrsa-in-a-rabbit-model-of-experimental-endocarditis-ee
#19
Cristina García-de-la-Mària, Oriol Gasch, Javier García-Gonzalez, Dolors Soy, Evelyn Shaw, Juan Ambrosioni, Manel Almela, Juan M Pericàs, Adrián Tellez, Carlos Falces, Marta Hernandez-Meneses, Elena Sandoval, Eduard Quintana, Barbara Vidal, Jose M Tolosana, David Fuster, Jaume Llopis, Miquel Pujol, Asuncion Moreno, Francesc Marco, Jose M Miró
This study aims to investigate whether the addition of fosfomycin or cloxacillin to daptomycin provides better outcomes in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) experimental aortic endocarditis in rabbits. Five MRSA strains were used to perform in vitro time-kill studies at standard (105) and high (108) inocula. Combined therapy was compared with daptomycin monotherapy treatment in the MRSA experimental endocarditis model. A human-like pharmacokinetics model was applied and the equivalents of cloxacillin 2g/4hiv, fosfomycin 2g/6h iv and daptomycin 6-10mg/kg/d iv were administered...
April 2, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29593912/antimicrobial-susceptibility-among-colistin-sulbactam-and-fosfomycin-and-a-synergism-study-of-colistin-in-combination-with-sulbactam-or-fosfomycin-against-clinical-isolates-of-carbapenem-resistant-acinetobacter-baumannii
#20
Sombat Leelasupasri, Wichai Santimaleeworagun, Tossawan Jitwasinkul
This in vitro study aimed to determine the activity of colistin plus sulbactam and colistin plus fosfomycin against carbapenem-resistant A. baumannii (CRAB). Fifteen clinical isolates were obtained from patients admitted to Phyathai II International Hospital, Bangkok, Thailand, from August 2014 to April 2015. The antimicrobial susceptibilities of colistin, sulbactam, and fosfomycin were evaluated using the E-test or broth microdilution and the synergistic activity of the antibacterial combinations (colistin plus sulbactam or fosfomycin) was determined using the chequerboard method...
2018: Journal of Pathogens
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