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Mei-Hsing Chuang, Kuo-Meng Liao, Yao-Min Hung, Paul Yung-Pou Wang, Yi-Chang Chou, Pesus Chou
OBJECTIVES: To examine whether older people with abnormal thyroid function are more likely to develop chronic kidney disease (CKD) over a 5-year follow-up period. DESIGN: Retrospective cohort study. SETTING: Health examination data from the Taipei Databank for Public Health Analysis. PARTICIPANTS: Individuals aged 65 and older (N = 41,454). MEASUREMENTS: Thyroid-stimulating hormone (TSH) levels were repeatedly measured, and subjects were categorized into four thyroid function groups (hyperthyroid, euthyroid, subclinical hypothyroid, overt hypothyroid)...
June 2016: Journal of the American Geriatrics Society
Domenico Scrutinio, Andrea Passantino, Pietro Guida, Enrico Ammirati, Fabrizio Oliva, Simona Sarzi Braga, Maria Teresa La Rovere, Rocco Lagioia, Maria Frigerio
BACKGROUND: To assess the impact of comorbidities on long-term all-cause mortality in patients hospitalized with exacerbated signs/symptoms of previously chronic stable HF (AE-CHF). METHODS: 1119 patients admitted for AE-CHF and with NT-proBNP levels >900pg/mL were enrolled. Univariable and multivariable Cox analyses were performed to assess the association of age, gender, hypertension, diabetes, obesity, atrial fibrillation, coronary heart disease (CHD), chronic obstructive pulmonary disease, previous cerebrovascular accidents, chronic liver disease (CLD), thyroid disease, renal impairment (RI), and anemia with 3-year all-cause mortality...
June 1, 2016: European Journal of Internal Medicine
Junjuan Yang, Huafeng Guo, Shugui Ding, Beibei Tao, Xinhua Zhang
OBJECTIVE: To investigate if women with subclinical hypothyroidism (SCH), positive thyroid gland peroxidase antibody (TPOAb) in early pregnancy accepted treatment or not had effect on perinatal outcomes. METHODS: 15 000 pregnant women who delivered in Women and Infants Hospital of Zhengzhou from January 1, 2013 to June 30, 2014 were recruited retrospectively. Among them, 2 042 women had SCH in early pregnancy. The diagnostic standard of SCH was serum free thyroxine (FT4) between 12...
September 2015: Zhonghua Fu Chan Ke za Zhi
Simon D S Fraser, Paul J Roderick, Carl R May, Natasha McIntyre, Christopher McIntyre, Richard J Fluck, Adam Shardlow, Maarten W Taal
BACKGROUND: Multimorbidity is a growing concern for healthcare systems, with many countries experiencing demographic transition to older population profiles. Chronic kidney disease (CKD) is common but often considered in isolation. The extent and prognostic significance of its comorbidities is not well understood. This study aimed to assess the extent and prognostic significance of 11 comorbidities in people with CKD stage 3. METHODS: A prospective cohort of 1741 people with CKD stage 3 was recruited from primary care between August 2008 and March 2010...
2015: BMC Nephrology
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Fereidoun Azizi
BACKGROUND: Pregnancy has a huge impact on the thyroid function in both healthy women and those that have thyroid dysfunction. The prevalence of thyroid dysfunction in pregnant women is relatively high. OBJECTIVE: The objective of this review was to increase awareness and to provide a review on adverse effect of thyroid dysfunction including hyperthyroidism, hypothyroidism and thyroid autoimmune positivity on pregnancy outcomes. MATERIALS AND METHODS: In this review, Medline, Embase and the Cochrane Library were searched with appropriate keywords for relevant English manuscript...
July 2015: Iranian Journal of Reproductive Medicine
András Szentkirályi, Henry Völzke, Wolfgang Hoffmann, Julianne Winkelmann, Klaus Berger
STUDY OBJECTIVES: Multimorbidity is a risk factor for incident restless legs syndrome (RLS). In this relationship, the potential role of known genetic risk loci for RLS has not been studied. Our aim was to evaluate whether carriers of specific RLS risk alleles have higher comorbidity burden than noncarriers. METHODS: The Dortmund Health Study (DHS) and the Study of Health in Pomerania (SHIP) are two independent cohort studies in Germany based on age-stratified, random samples drawn from the respective population registers...
January 2016: Sleep
Jolanta Malyszko, E Koc-Zorawska, N Levin-Iaina, Jacek Malyszko
BACKGROUND: In patients after kidney transplantation, anemia is relatively common and is associated with impaired kidney function, subclinical inflammatory state, and immunosuppressive treatment. Zonulin-prehaptoglobin-2, a newly discovered protein, is necessary for integrity of intracellular tight junctions in the gut. Taking into consideration iron metabolism, including its absorption in the gut, we designed a cross-sectional study to look for the possible interactions among zonulin, iron status, and anemia in kidney transplant recipients...
October 2014: Transplantation Proceedings
Eran Hadar, Eran Ashwal, Moshe Hod
Preconceptional care is a set of interventions, aimed to identify and modify medical, behavioral, and social risks to a woman's health and her pregnancy outcome, prior to conception. Diagnosing and treating some of the common noncommunicable diseases (NCDs) may have an impact on pregnancy outcome. Ample time should be allowed to properly intervene in some of the following situations: hypertension, diabetes, obesity, systemic lupus erythematosus, thyroid disease, anemia, epilepsy, asthma, and cardiac disease...
January 2015: Best Practice & Research. Clinical Obstetrics & Gynaecology
András Szentkirályi, Henry Völzke, Wolfgang Hoffmann, Claudia Trenkwalder, Klaus Berger
OBJECTIVE: Our aim was to evaluate the association between the cumulative effect of comorbidity and the risk of restless legs syndrome (RLS) in 2 population-based German cohort studies. METHODS: The Dortmund Health Study (DHS) (n = 1,312; median follow-up time: 2.1 years) and the Study of Health in Pomerania (SHIP) (n = 4,308; median follow-up time: 5.0 years) were used for the analyses. RLS was assessed at baseline and follow-up according to the RLS minimal criteria...
June 3, 2014: Neurology
K L Moore, W J Boscardin, M A Steinman, J B Schwartz
OBJECTIVE: There are limited data on combinations of co-morbid conditions to guide efforts to improve therapeutic strategies in patients with multiple co-morbid conditions. To some extent, this may be due to limited data on combinations of co-morbid conditions in patient groups. Our goal was to determine the most common co-morbid medical conditions in older residents of U.S. nursing homes and identify sex differences in prevalences and changes across the agespan of nursing residents. DESIGN: Cross sectional analysis of National Nursing Home Survey (NNHS)--a nationally representative sample with comprehensive medical data on nursing home residents...
April 2014: Journal of Nutrition, Health & Aging
Beatriz Poblador-Plou, Amaia Calderón-Larrañaga, Javier Marta-Moreno, Jorge Hancco-Saavedra, Antoni Sicras-Mainar, Michael Soljak, Alexandra Prados-Torres
BACKGROUND: The epidemiologic study of comorbidities of an index health problem represents a methodological challenge. This study cross-sectionally describes and analyzes the comorbidities associated with dementia in older patients and reviews the existing similarities and differences between identified comorbid diseases using the statistical methods most frequently applied in current research. METHODS: Cross-sectional study of 72,815 patients over 64 seen in 19 Spanish primary care centers during 2008...
2014: BMC Psychiatry
Marta Toni García, Emma Anda Apiñániz, Juan Pablo, Martínez de Esteban, Patricia Munárriz Alcuaz, María José Goñi Iriarte, Lluís Forga Llenas
Autoimmune polyendocrine syndrome type II (APS-II) is the most common immunoendocrinopathy syndrome. APS-II is defined by the development of two or more of the following entities: primary adrenal insufficiency (Addison's disease), Graves' disease, type 1A diabetes mellitus, autoimmune thyroiditis, primary hypogonadism, celiac disease, and myasthenia gravis. Other frequent clinical findings are vitiligo, alopecia, pernicious anemia and/or serositis. Primary adrenal insufficiency in these patients affects the adrenal cortex, which is destroyed by autoantibodies against 21-hydroxylase...
December 2008: Endocrinología y Nutrición: órgano de la Sociedad Española de Endocrinología y Nutrición
Kelly L Moore, W John Boscardin, Michael A Steinman, Janice B Schwartz
OBJECTIVES: To investigate patterns in prevalences of chronic medical conditions over the age span of long-term stay nursing home residents and between the sexes with data from the 2004 National Nursing Home Survey (NNHS). DESIGN: Retrospective, cross-sectional study. SETTING: U.S. nursing homes. PARTICIPANTS: Nationally representative sample comprising 11,788 long-term stay residents (3,003 (25%) men, 8,785 (75%) women) aged 65 and older...
April 2012: Journal of the American Geriatrics Society
Ariel Linden, Thomas J Biuso, Susan W Butterworth
No abstract text is available yet for this article.
April 2010: Journal of Family Practice
Deepali Prasad, Harshit S Khara, Mohit Gupta, Paul Sterman
INTRODUCTION: Celiac disease is associated with a variety of autoimmune diseases such as type 1 diabetes mellitus, autoimmune thyroid disorders, Sjogren's syndrome and IgA nephropathy, however membranous nephropathy is not recognized amongst one of them. CASE PRESENTATION: We report a rare case of nephrotic syndrome due to membranous nephropathy in a patient with celiac disease. A 77-years-old male patient presented with uncontrolled hypertension, anemia and acute renal failure...
2009: Cases Journal
Hiroaki Yoshida, Kaname Tsuji, Takeichi Sakata, Akihito Nakagawa, Shosuke Morita
The aim of this retrospective study of patients with tongue pain who showed no improvement after initial treatment and examination was to find out if their lack of response correlated with serum concentrations of zinc, vitamin B12, folic acid, and copper, and if it was associated with coexisting systemic diseases. We studied 311 patients for whom we had data about serum concentrations of these elements, and recorded whether they had any systemic diseases and were taking medicines regularly. One patient (0.3%) had a copper concentration outside the reference range; 2 patients (0...
September 2010: British Journal of Oral & Maxillofacial Surgery
Laila J Tata, Sarah A Lewis, Tricia M McKeever, Chris J P Smith, Pat Doyle, Liam Smeeth, Joe West, Richard B Hubbard
RATIONALE: Previous studies have raised concern that women with asthma have increased risks of adverse obstetric and pediatric complications, but these have generally been underpowered. OBJECTIVES: To quantify risks of major adverse pregnancy outcomes and obstetric complications in women with and without asthma. METHODS: We extracted information on 281,019 pregnancies from the Health Improvement Network database between 1988 and 2004. We analyzed the data using logistic regression...
May 15, 2007: American Journal of Respiratory and Critical Care Medicine
Serge A Jabbour, Batya B Davidovici, Ronni Wolf
Dermatologists may also encounter patients presenting with skin lesions that reflect an underlying endocrine disorder not commonly seen in daily practice. Some of these endocrine disorders include glucagonoma, neurofibromatosis type 1, McCune-Albright syndrome, multiple endocrine neoplasia, the Carney complex, carcinoid tumors, and mastocytosis. The clinical syndrome classically associated with glucagonoma includes necrolytic migratory erythema, weight loss, diabetes mellitus, anemia, cheilitis, venous thrombosis, and neuropsychiatric symptoms...
July 2006: Clinics in Dermatology
Athanasios Aessopos, Dimitrios Farmakis, Maria Tsironi, Evanthia Diamanti-Kandarakis, Marina Matzourani, Christina Fragodimiri, Antonia Hatziliami, Markisia Karagiorga
BACKGROUND: Homozygous sickle-cell anemia and beta-thalassemia are characterized by impaired endothelial function, while data on arterial stiffness have hitherto been conflicting. We sought to investigate aortic elastic properties and endothelial function in sickle-thalassemia, which combines molecular and clinical features of the above conditions. METHODS AND RESULTS: Forty-seven sickle-thalassemia patients, younger than 45 years, with preserved left ventricular (LV) function and no history of smoking, systemic or pulmonary hypertension, diabetes mellitus, dyslipidemia or thyroid disease, along with 40 healthy controls were studied...
April 2007: Atherosclerosis
Shagufta Yasmeen, Patrick S Romano, Michael E Schembri, Janet M Keyzer, William M Gilbert
OBJECTIVE: The objective of the study was to estimate the validity of obstetric procedures and diagnoses in California patient discharge data. STUDY DESIGN: We randomly sampled 1611 deliveries from 52 of 267 California hospitals that performed more than 678 eligible deliveries in 1992 to 1993. We compared hospital-reported procedures and diagnoses against our recoding of the same records. RESULTS: Cesarean, forceps, and vacuum delivery were accurately reported, with sensitivities and positive predictive values exceeding 90%...
April 2006: American Journal of Obstetrics and Gynecology
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