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Serge Doan, Flore Amat, Eric Gabison, Sarah Saf, Isabelle Cochereau, Jocelyne Just
INTRODUCTION: Vernal keratoconjunctivis (VKC) is a severe form of pediatric ocular allergy, characterized by acute and chronic corneoconjunctival inflammation that may lead to visual sequelae. Although topical immunosuppressive drugs such as cyclosporine are usually effective, some severe forms may be refractory and require prolonged steroid therapy. Very few papers report the use of omalizumab in VKC in the literature. In the present study, we describe our clinical experience with omalizumab in severe VKC children...
December 1, 2016: Ophthalmology and Therapy
Jun Shoji, Hiroshi Aso, Noriko Inada
PURPOSE: This study investigated the clinical usefulness of a multiple tear cytokine/chemokine test by simultaneously determining tear levels of CC chemokine ligand 17 (CCL17)/thymus and activation-regulated chemokine (TARC), CCL24/eotaxin-2, and interleukin-16 (IL-16) for assessing acute and chronic allergic inflammation in allergic conjunctival disorders (ACDs). SUBJECTS AND METHODS: This study included 37 patients with ACD and 11 healthy adults (controls). Patients with ACDs were divided into the following three groups; patients with allergic conjunctivitis (AC group, n = 17), patients with atopic keratoconjunctivitis (AKC group, n = 6), and patients with vernal keratoconjunctivitis (VKC group, n = 14)...
November 29, 2016: Current Eye Research
Anna Maria Zicari, Arianna Cafarotti, Francesca Occasi, Valeria Lollobrigida, Marcella Nebbioso, Irene Pecorella, Giovanna De Castro, Alberto Spalice, Lorenzo Loffredo, Maria Pia Villa, Marzia Duse
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology still remains unclear although endocrine, genetic, neurogenic and environmental factors have been implicated. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared to the healthy children and investigate the relationship between its levels and disease severity...
February 2017: Current Medical Research and Opinion
Banu Bozkurt, Hasibe Artac, Hulya Ozdemir, Ali Ünlü, Mete Kaan Bozkurt, Murat Irkec
PURPOSE: To evaluate serum 25-hydroxyvitamin D [25(OH)D3] levels of vernal keratoconjunctivitis (VKC) children. METHODS: A total of 62 non-atopic healthy children (64.5% male, mean age 10.79 ± 3.3 years) and 29 VKC children (75.9%, mean age 12.17 ± 2.7 years) were included in the study. Serum 25(OH)D3 levels measured by HPLC were compared between the two groups and a p value of <0.05 was considered as statistically significant. RESULTS: The mean serum 25(OH)D3 level of VKC group was significantly lower than in the control group (11...
October 24, 2016: Ocular Immunology and Inflammation
Yukiko Shiraki, Jun Shoji, Noriko Inada
Purpose. This study aimed to evaluate the clinical efficacy of using expression levels of CCL24 (eotaxin-2) mRNA on the ocular surface as a biomarker in patients with vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC). Methods. Eighteen patients with VKC or AKC (VKC/AKC group) and 12 control subjects (control group) were enrolled in this study. The VKC/AKC clinical score was determined by objective findings in patients by using the 5-5-5 exacerbation grading scale. All subjects underwent modified impression cytology and specimens were obtained from the upper tarsal conjunctiva...
2016: Journal of Ophthalmology
Dereje Hayilu, Kbrom Legesse, Natinael Lakachew, Mulusew Asferaw
BACKGROUND: Vernal keratoconjunctivitis (VKC) is a common cause of ocular morbidity in children in warm dry climates such as Sub-Saharan Africa and accounts for about 3 % of serious ophthalmic cases in tropical countries. The purpose of this study was to assess the prevalence and associated factors of vernal keratoconjunctivitis among children living in Gondar City, Ethiopia. METHODS: A Cross Sectional Design study was carried out in 737 children under the age of 18 years in Gondar City from April to May 2015...
September 29, 2016: BMC Ophthalmology
Roberto Caputo, Francesco Versaci, Neri Pucci, Cinzia de Libero, Gioia Danti, Salvatore De Masi, Rita Mencucci, Elio Novembre, Bennie H Jeng
PURPOSE: To evaluate the prevalence of keratoconus (KC) and other corneal abnormalities by means of videokeratography and tomography in a large series of patients affected by vernal keratoconjunctivitis (VKC). DESIGN: Cross-sectional study. METHODS: • Setting: Single-center, children's hospital. • Study Population: 651 consecutive patients with VKC and a control group of 500 were prospectively recruited between May 2012 and September 2013, with a minimum follow-up of 12 months...
September 14, 2016: American Journal of Ophthalmology
Rakesh K Barot, Satish C Shitole, Nupur Bhagat, Deepak Patil, Pawan Sawant, Kalpita Patil
INTRODUCTION: Allergic Ocular Diseases (AODs) like Atopic Keratoconjunctivitis (AKC) and Vernal Keratoconjunctivitis (VKC) are chronic forms of ocular allergy that can cause severe visual complications. Pathogenesis of AODs is uncertain and treatment has been a challenge for ophthalmologists. Tacrolimus, a 23-member cyclic macrolide lactone derived from [streptomyces tsukubaensis] now in ointment form has been successfully used in AODs. AIM: To study the therapeutic effect of 0...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
Xiaofen Zheng, Juan Yao, Bing Li
Background. The pathogenesis of allergic conjunctivitis has not been clearly established. Moreover, previous studies fail to consider human models of allergic conjunctivitis. This study investigated the expression of thymic stromal lymphopoiet in TSLP and its downstream molecules in conjunctival scrappings and tear. Methods. This cross-sectional study compares patients with vernal keratoconjunctivitis (VKC), seasonal allergic conjunctivitis (SAC), and perennial allergic conjunctivitis (PAC) with normal controls...
2016: Journal of Ophthalmology
Susanna Esposito, Giulia Fior, Alessandro Mori, Silvia Osnaghi, Daniele Ghiglioni
Vernal keratoconjunctivitis (VKC) is an inflammatory disease of the ocular surface. It commonly occurs in the first decade of life, has a wide geographical distribution, and usually occurs in warm, dry areas. The pathogenesis of VKC seems to have an immune, nervous, and endocrine basis. The most common eye symptoms are itching, discharge, tearing, eye irritation, redness of the eyes, and photophobia. Although VKC generally has a good prognosis, the lack of clarity regarding the origin of the disease makes treatment a challenge for pediatricians and ophthalmologists...
October 2016: Paediatric Drugs
Mohammad Hosein Validad, Hossein Ali Khazaei, Masoud Pishjoo, Zohre Safdari
INTRODUCTION: Vernal keratoconjunctivitis (VKC) is a bilateral multi-factorial disease. The pathogenesis of this disease is not obviously determined, but the role of various inflammatory cytokines has been specified. This study has provided a comparison between the level of interleukin-17 (IL17) in the serum and tears of case and control groups, and also the relationship between the level of this interleukin with severity of signs and symptoms of the disease. MATERIALS AND METHODS: This case-control study has been accomplished on 40 individuals (20 healthy people and 20 patients who suffer from VKC) in Al-Zahra Eye Center in 2014...
July 15, 2016: Seminars in Ophthalmology
Sunil Kumar, Wajeeha Al Khars
Vernal keratoconjunctivitis (VKC) is a chronic allergic inflammation of ocular surface involving the tarsal and/or bulbar conjunctiva. Signs of VKC are confined to the conjunctiva and cornea. The skin of the lid remains uninvolved. Here we report a case of 17 year-old male suffering from VKC who develops vitiligo of lid skin and lash poliosis. All ocular and systemic causes of localized skin and lash depigmentation were excluded in our patient by thorough clinical examination and investigations. During regular follow-up for two-year patient did not develop any ocular and systemic illness presenting as vitiligo and poliosis...
April 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Samrat Chatterjee, Deepshikha Agrawal
PURPOSE: To evaluate the efficacy of 0.03% tacrolimus in the treatment of corticosteroid-refractory vernal keratoconjunctivitis (VKC). METHODS: This open-label study enrolled 30 patients with VKC who were not responding to topical corticosteroid treatment for at least 4 weeks. All patients were treated with 0.03% tacrolimus eye ointment 3 times daily, 0.05% ketotifen eye drops twice daily, and preservative-free artificial tears. Symptoms (itching, redness, watering, discharge, burning, and photophobia) and signs (conjunctival injection, papillae, cobblestone papillae, limbal inflammation, or hypertrophy and corneal epithelial staining) were graded on a 4-point scale at enrolment, after 4 weeks, and at the end of treatment period, which was at 12 weeks...
November 2016: Cornea
Hatem M Marey, Sameh S Mandour, Osama A El Morsy, Hassan G Farahat, Shaimaa M Shokry
PURPOSE: To evaluate the prevalence of vernal keratoconjunctivitis (VKC) and its impact on school children in Egypt. METHODS: A total of 3,706 students from six randomly selected schools of Menoufia were included where 126 had symptoms according to the VKC related symptoms questionnaire. Selected children were referred to a hospital for further assessment. RESULTS: The mean age of included children was 8.79±31.87 years, with a VKC prevalence of 3...
April 29, 2016: Seminars in Ophthalmology
Kaspar Schuerch, Christoph Tappeiner, Beatrice E Frueh
PURPOSE: To analyse the long-term efficacy of corneal cross-linking (CXL) in children with keratoconus and to describe criteria for the detection of pseudoprogression. METHODS: Evaluation of retrospectively collected corneal topography (Placido system) and tomography (Scheimpflug system) results after CXL in children (age 18 or younger). Twenty-five patients (33 eyes) were included. Follow-up was assessed after 1, 2, 3 and 4 years. Progression was defined as an increase in maximal keratometry (Kmax) of at least one dioptre (D) in 1 year...
November 2016: Acta Ophthalmologica
Samir S Shoughy, Mahmoud O Jaroudi, Khalid F Tabbara
OBJECTIVE: The objective of this study was to evaluate the efficacy and safety of topical low-dose tacrolimus (0.01%) solution in patients with vernal keratoconjunctivitis (VKC). PATIENTS AND METHODS: A total of 62 consecutive patients with VKC refractory to conventional treatment were included retrospectively. Tacrolimus 0.01% ophthalmic solution was administered to patients twice daily after discontinuation of all previous topical medications. The duration of treatment ranged from 1 month to 29 months...
2016: Clinical Ophthalmology
Mohammad Soleimani, Seyed Ali Tabatabaei, Reza Mirshahi, Zohreh Nozarian, Mahmoud Jabbarvand Behrbouz
PURPOSE: To report 2 cases of Splendore-Hoeppli phenomenon, a rare histopathologic observation, as a late clinical finding in vernal keratoconjunctivitis (VKC). METHODS: We report the cases of 2 young women with subconjunctival nodules as a manifestation of Splendore-Hoeppli phenomenon with a history of severe VKC. RESULTS: After eliminating other conditions causing such a reaction, both patients were treated using frequent topical corticosteroid, plus topical cyclosporine 2% in one of patient...
June 2016: Cornea
Mohammad Naderan, Mohammad Taher Rajabi, Parviz Zarrinbakhsh, Anahita Bakhshi
PURPOSE: To investigate the association between keratoconus (KC) and allergic diseases. METHODS: In a prospective age- and sex-matched case--control study clinical data of 885 KC patients and 1526 controls were evaluated regarding the presence of various allergic diseases. Severity of KC and ophthalmic parameters of KC patients were compared between KC patients with and without allergic diseases. RESULTS: The prevalence of allergic diseases was significantly higher in KC patients...
March 25, 2016: Ocular Immunology and Inflammation
Alessandra Micera, Antonio Di Zazzo, Graziana Esposito, Roberto Sgrulletta, Virginia L Calder, Stefano Bonini
OBJECTIVE: Vernal keratoconjunctivitis (VKC) is a chronic recurrent bilateral inflammation of the conjunctiva associated with atopy. Several inflammatory and tissue remodeling factors contribute to VKC disease. The aim is to provide a chip-based protein analysis in tears from patients suffering from quiescent or active VKC. METHODS: This study cohort included 16 consecutive patients with VKC and 10 controls. Participants were subjected to clinical assessment of ocular surface and tear sampling...
2016: BioMed Research International
Hiroshi Fujishima, Naoko Okada, Kenji Matsumoto, Kazumi Fukagawa, Ayako Igarashi, Akio Matsuda, Junya Ono, Shoichiro Ohta, Hideki Mukai, Mamoru Yoshikawa, Kenji Izuhara
BACKGROUND: Chronic ocular allergic diseases such as vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC) are accompanied by serious comorbidities; however, the underlying pathogenesis remains obscure. Furthermore, diagnosing conjunctival lesions in patients with atopic dermatitis and estimating the severity in AKC are important for the treatment of ocular allergic diseases. OBJECTIVE: We addressed whether periostin, a novel mediator and biomarker in allergic inflammation, is involved in the pathogenesis of ocular allergic diseases and whether periostin can be a biomarker for these diseases...
August 2016: Journal of Allergy and Clinical Immunology
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