Huijie Cui, Wenqiang Zhang, Li Zhang, Yang Qu, Zhengxing Xu, Zhixin Tan, Peijing Yan, Mingshuang Tang, Chao Yang, Yutong Wang, Lin Chen, Chenghan Xiao, Yanqiu Zou, Yunjie Liu, Ling Zhang, Yanfang Yang, Yuqin Yao, Jiayuan Li, Zhenmi Liu, Chunxia Yang, Xia Jiang, Ben Zhang
BACKGROUND: The incidence of prostate cancer is increasing in older males globally. Age, ethnicity, and family history are identified as the well-known risk factors for prostate cancer, but few modifiable factors have been firmly established. The objective of this study was to identify and evaluate various factors modifying the risk of prostate cancer reported in meta-analyses of prospective observational studies and mendelian randomization (MR) analyses. METHODS AND FINDINGS: We searched PubMed, Embase, and Web of Science from the inception to January 10, 2022, updated on September 9, 2023, to identify meta-analyses and MR studies on prostate cancer...
March 15, 2024: PLoS Medicine