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https://www.readbyqxmd.com/read/28256328/additive-prognostic-values-of-nt-probnp-and-exercise-stress-echocardiography-in-asymptomatic-patients-with-degenerative-mitral-regurgitation-and-preserved-left-ventricular-ejection-fraction
#1
Sung-Ji Park, Eun Jeong Cho, Joonghyun Ahn, Keumhee Carriere, Eun Kyoung Kim, Ga Yeon Lee, Sung-A Chang, Jin-Oh Choi, Sang-Chol Lee, Seung Woo Park
BACKGROUND: Exercise stress echocardiography (ESE) can be used to identify left ventricular (LV) dysfunction in asymptomatic chronic MR. NT-proBNP is the best marker for monitoring LV dysfunction. OBJECTIVE: The aim of this study was to estimate the complementary prognostic value of ESE and NT-proBNP in asymptomatic degenerative MR with preserved LV ejection fraction (EF). METHODS: Symptom-limited treadmill ESE was performed in 114 asymptomatic with significant degenerative MR (ERO >20mm, RV >30ml), LV end-systolic diameter <40mm and preserved LV function (EF >60%)...
February 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28253598/-atrial-fibrillation-in-patients-with-obstructive-hypertrophic-cardiomyopathy-clinical-characteristics-and-risk-factors
#2
X Wu, H Cui, J J Wang, M H Xiao, J Lu, X X Zheng, Y Guo, S Y Wang, X H Huang
Objective: To evaluate the clinical characteristics and risk factors for atrial fibrillation(AF)in patients with obstructive hypertrophic cardiomyopathy(OHCM). Methods: Patients with OHCM hospitalized in Fuwai Hospital from March 2011 to January 2016 were enrolled in the present study. Each patient underwent examinations including transthoracic echocardiography, body surface electrocardiograph or dynamic electrocardiogram (Holter). Cardiac troponin I (cTNI) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP)levels were tested and clinical profiles were collected...
March 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28222017/evaluation-of-biotin-interference-on-immunoassays-new-data-for-troponin-i-digoxin-nt-pro-bnp-and-progesterone
#3
Théo Willeman, Olivier Casez, Patrice Faure, Anne Sophie Gauchez
No abstract text is available yet for this article.
February 21, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28216549/role-of-right-ventricular-dysfunction-and-diabetes-mellitus-in-n-terminal-pro-b-type-natriuretic-peptide-response-of-patients-with-severe-mitral-regurgitation-and-heart-failure-after-mitraclip
#4
Hidehiro Kaneko, Michael Neuss, Jens Weissenborn, Christian Butter
MitraClip (MC) is an alternative therapeutic option for patients with severe mitral regurgitation (MR) who are at high surgical risk. Most candidates for MC have severe heart failure (HF) with increased N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels. We sought to clarify the response of NT-pro BNP after MC and to identify the determinants of NT-pro BNP nonresponders. Among 136 consecutive patients successfully treated with MC, we excluded 20 patients due to low baseline NT-pro BNP levels and therefore examined 116 patients...
February 20, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28123475/clinical-effect-of-preoperative-high-dose-atorvastatin-against-no-reflow-after-pci
#5
Wenbo Liu, Zhipeng Zou, Haipeng Jiang, Qiang Li, Fangming Guo, Zhen Wang, Hongguang Zhu
The aim of the present study was to evaluate the use of preoperative high-dose atorvastatin to prevent the no-reflow phenomenon after percutaneous coronary intervention (PCI). A total of 138 patients with ST-segment elevation myocardial infarction, admitted from March 2014 to January 2015, were enrolled and randomly divided into 3 groups of 46 individuals each. The groups included a control group in which patients were not treated with atorvastatin before PCI; a conventional-dose atorvastatin treatment group in which patients received a single dose of 20 mg at bedtime one day prior to PCI; and a high-dose atorvastatin treatment group in which patients were treated with 40 mg divided in two doses the day before PCI...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28103203/the-change-in-nt-pro-bnp-and-post-ptmc-echocardiography-parameters-in-patients-with-mitral-stenosis-a-pilot-study
#6
Morteza Safi, Fariba Bayat, Zahra Ahmadi, Masood Shekarchizadeh, Isa Khaheshi, Mohammadreza Naderian
BACKGROUND: The change in the level of NT-Pro-BNP (N-terminal Pro-Brain Natriuretic Peptide) is now considered as a reflection of the hemodynamic alterations and its circulatory reductions reported early after successful PTMC (percutaneous transvenous mitral commissurotomy). The present study aims to assess the change in the level of NT-Pro BNP following PTMC in patients with mitral stenosis and also to determine the association between circulatory NT-Pro BNP reduction and post-PTMC echocardiography parameters...
January 18, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28101033/maximizing-the-benefit-cost-ratio-of-anthracyclines-in-metastatic-breast-cancer-case-report-of-a-patient-with-a-complete-response-to-high-dose-doxorubicin
#7
Kevin Shee, Alan T Kono, Susan P D'Anna, Mark A Seltzer, Xiaoying Lu, Todd W Miller, Mary D Chamberlin
Despite the clinical efficacy of anthracycline agents such as doxorubicin, dose-limiting cardiac toxicities significantly limit their long-term use. Here, we present the case of a 33-year-old female patient with extensive metastatic ER+/PR+/HER2- mucinous adenocarcinoma of the breast, who was started on doxorubicin/cyclophosphamide therapy after progressing on paclitaxel and ovarian suppressor goserelin with aromatase inhibitor exemestane. The patient was comanaged by cardiology, who carefully monitored measures of cardiac function, including EKGs, serial echocardiograms, and profiling of lipids, troponin, and pro-BNP every 2 months...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/28067531/prognostic-value-of-n-terminal-prohormone-brain-natriuretic-peptide-for-in-hospital-and-long-term-outcomes-in-patients-with-infective-endocarditis
#8
Xue-Biao Wei, Yuan-Hui Liu, Peng-Cheng He, Dan-Qing Yu, Ying-Ling Zhou, Ning Tan, Ji-Yan Chen
Background Limited research studies with a large sample size were performed to evaluate the prognostic value of N-terminal pro-B-type natriuretic peptide (NT-proBNP) for in-hospital or long-term poor outcomes in patients with infective endocarditis. Methods A total of 703 patients with infective endocarditis were enrolled and divided into four groups according to admission NT-pro-BNP (pg/mL) quartiles: Q1 (<258), Q2 (258-1054), Q3 (1055-3522) and Q4 (>3522). Multivariate regression was used to determine independent risk of NT-proBNP for in-hospital and one-year death...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28009952/hemodynamic-improvement-at-three-months-after-mitraclip%C3%A3-%C3%A2-treatment-in-end-stage-heart-failure-patients-with-functional-mitral-regurgitation
#9
Sebastian Barth, Martina B Hautmann, Sebastian Kerber, Frank Gietzen, Michael Zacher, Philipp Halbfass, Patrick Müller, Anja Schade, Thomas Deneke, Anno Diegeler, Bernhard Schieffer, Karsten Hamm
BACKGROUND: Functional mitral regurgitation (FMR) is common in patients with advanced heart failure and impaired left ventricular function. The study aim was to examine functional and hemodynamic effects at three months after MitraClip® implantation in high-risk surgical patients with FMR. METHODS: A group of 93 patients was rejected for surgical treatment by heart-team decisions due to an inacceptable risk for conventional mitral valve surgery. Between October 2011 and May 2015, 89 of these patients (96%) were treated successfully with MitraClip implantation...
July 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/27999930/impact-of-baseline-tricuspid-regurgitation-on-long-term-clinical-outcomes-and-survival-after-interventional-edge-to-edge-repair-for-mitral-regurgitation
#10
Robert Schueler, Can Öztürk, Jan-Malte Sinning, Nikos Werner, Armin Welz, Christoph Hammerstingl, Georg Nickenig
AIMS: Tricuspid regurgitation (TR) in patients with mitral valve disease is associated with poor outcome and mortality. Only limited data on the impact of TR on functional outcome and survival in patients undergoing MitraClip procedures are available. METHODS AND RESULTS: 261 patients (mean age 76.6 ± 10, EuroScore 15.9 ± 15.1%) with symptomatic mitral regurgitation (MR) (75.2% functional MR) undergoing MitraClip procedure were included and followed for 721 ± 19...
December 21, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/27996318/brain-natriuretic-peptide-as-a-biomarker-of-asymptomatic-clozapine-related-heart-dysfunction-a-criterion-for-a-more-cautious-administration
#11
Vincenzo Prisco, Petrosino Monica, Germano Fiore, Annamaria Tridente, Antonietta La Rocca, Francesco Catapano, Michele Fabrazzo
Clozapine-related pericarditis is a rare side effect of the drug. We reported the clinical cases of two women, aged 22 and 28 years, affected by schizophrenia with pericarditis symptoms related to clozapine treatment of 200 mg/day. Clozapine was discontinued in both patients, resulting in normalization of the ECG changes, and echocardiography confirmed the progressive disappearance of the pericardial effusion. Interestingly, while inflammatory indices and pro-brain natriuretic peptide (pro-BNP) plasma levels were high in both patients, only one of them showed tachycardia, subjective chest pain, shortness of breath and dyspnea, with a clinical symptomatology suggesting a cardiac involvement...
December 20, 2016: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/27982270/elevated-heart-rate-is-associated-with-cardiac-denervation-in-patients-with-heart-failure-a-123-iodine-mibg-myocardial-scintigraphy-study
#12
Aline Sterque Villacorta, Humberto Villacorta, Jenne Serrão de Souza, José Antônio Caldas Teixeira, Maria Clara S S S Muradas, Christiane Rodrigues Alves, Bernardo Campanário Precht, Pilar Porto, Letícia Ubaldo, Cláudio Tinoco Mesquita, Antônio Cláudio Lucas da Nóbrega
Background: In the Systolic Heart Failure Treatment With the If Inhibitor Ivabradine Trial (SHIFT), heart rate (HR) reduction with ivabradine was associated with improved survival and reduced hospitalizations in patients with heart failure (HF). The mechanisms by which elevated HR increases mortality are not fully understood. Objective: To assess the relationship of baseline HR with clinical, neurohormonal and cardiac sympathetic activity in patients with chronic HF and elevated HR...
November 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27956645/amino-terminal-pro-brain-natriuretic-peptide-predicts-all-cause-mortality-in-patients-with-chronic-obstructive-pulmonary-disease-systematic-review-and-meta-analysis
#13
Rita Pavasini, Guido Tavazzi, Simone Biscaglia, Federico Guerra, Alessandro Pecoraro, Fatima Zaraket, Francesco Gallo, Giosafat Spitaleri, Marco Contoli, Roberto Ferrari, Gianluca Campo
Natriuretic peptides (NPs) are a family of prognostic biomarkers in patients with heart failure (HF). HF is one of the most frequent comorbidities in patients with chronic obstructive pulmonary disease (COPD). However, the prognostic role of NP in COPD patients remains unclear. The aim of this meta-analysis was to evaluate the relation between NP and all-cause mortality in COPD patients. We performed a systematic review and meta-analysis of observational studies assessing prognostic implications of elevated NP levels on all-cause mortality in COPD patients...
December 12, 2016: Chronic Respiratory Disease
https://www.readbyqxmd.com/read/27955618/n-terminal-pro-brain-natriuretic-peptide-improves-the-c-acs-risk-score-prediction-of-clinical-outcomes-in-patients-with-st-elevation-myocardial-infarction
#14
Peng-Cheng He, Chong-Yang Duan, Yuan-Hui Liu, Xue-Biao Wei, Shu-Guang Lin
BACKGROUND: It remained unclear whether the combination of the Canada Acute Coronary Syndrome Risk Score (CACS-RS) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) could have a better performance in predicting clinical outcomes in acute ST-elevation myocardial infarction (STEMI) patients with primary percutaneous coronary intervention. METHODS: A total of 589 consecutive STEMI patients were enrolled. The potential additional predictive value of NT-pro-BNP with the CACS-RS was estimated...
December 12, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27908301/utility-of-b-type-natriuretic-peptides-in-the-assessment-of-patients-with-systemic-sclerosis-associated-pulmonary-hypertension-in-the-pharos-registry
#15
Lorinda Chung, Robert M Fairchild, Daniel E Furst, Shufeng Li, Firas Alkassab, Marcy B Bolster, Mary Ellen Csuka, Chris T Derk, Robyn T Domsic, Aryeh Fischer, Tracy Frech, Mardi Gomberg-Maitland, Jessica K Gordon, Monique Hinchcliff, Vivien Hsu, Laura K Hummers, Dinesh Khanna, Thomas A Jr Medsger, Jerry A Molitor, Ivana R Preston, Elena Schiopu, Lee Shapiro, Faye Hant, Richard Silver, Robert Simms, John Varga, Virginia D Steen, Roham T Zamanian
OBJECTIVES: To assess the utility of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) in detecting and monitoring pulmonary hypertension (PH) in systemic sclerosis (SSc). METHODS: PHAROS is a multicenter prospective cohort of SSc patients at high risk for developing pulmonary arterial hypertension (SSc-AR-PAH) or with a definitive diagnosis of SSc-PH. We evaluated 1) the sensitivity and specificity of BNP≥64 and NT-proBNP≥210 pg/mL for the detection of SSc-PAH and/ or SSc-PH in the SSc-AR-PAH population; 2) baseline and longitudinal BNP and NT-proBNP levels as predictors of progression to SSc-PAH and/or SSc-PH; 3) baseline BNP≥180, NT-proBNP≥553 pg/mL, and longitudinal changes in BNP and NT-proBNP as predictors of mortality in SSc-PH diagnosed patients...
November 10, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27900955/serum-levels-of-n-terminal-pro-b-type-natriuretic-peptide-as-a-diagnostic-marker-for-left-ventricular-dysfunction-in-children-with-end-stage-renal-disease-on-hemodialysis
#16
Amr Mohamed Zoair, Maher Ahmed Abdel-Hafez, Wegdan Mawlana, Mohamed Abdel-Rahman Sweylam
The objective of this study was to determine the diagnostic cutoff value of N-terminal-pro B-type natriuretic peptide (NT-pro BNP) as a marker of left ventricular (LV) dysfunction in children with end-stage renal disease (ESRD) on regular hemodialysis (HD). The study was carried out on thirty children with ESRD on regular HD and thirty healthy controls. Echocardiographic studies were done, including a conventional mode for ejection fraction, fractional shortening, tissue Doppler imaging, and longitudinal global strain by speckle tracking...
November 2016: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/27899856/effect-of-spironolactone-on-plasma-apelin-12-levels-in-patients-with-chronic-systolic-heart-failure
#17
Mustafa Topuz, Mehmet Cosgun, Oğuz Akkuş, Atilla Bulut, Omer Sen, Ayşe Nur Topuz, Murat Caylı
BACKGROUND: The aim of this study was to determine whether spironolactone therapy has an effect on serum apelin-12 levels in heart failure with reduced ejection fraction (HFrEF) patients. METHODS: Eighty outpatients previously diagnosed with HFrEF were enrolled in the current study. Included patients were taking only standard heart failure therapy (ST) (angiotensin converting enzyme or angiotensin receptor blocker, beta-blockers, loop diuretics and anticoagulant or antiagregan agents) without a mineralocorticoid receptor antagonists (MRA) because of its side effects, and were designated the non-MRA group; those patients taking 25 mg/daily spironolactone in addition to the ST were deemed the MRA group...
November 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27895666/cardiometabolic-risk-in-hyperlipidemic-men-and-women
#18
Michael Leutner, Christian Göbl, Alice Wielandner, Eleonora Howorka, Marlies Prünner, Latife Bozkurt, Jürgen Harreiter, Helmut Prosch, Oliver Schlager, Silvia Charwat-Resl, Alexandra Kautzky-Willer
Objective. The aim of this study was to evaluate sex specific differences of metabolic and clinical characteristics of treated hyperlipidemic men and women (HL-men and HL-women). Methods. In this study vascular and metabolic characteristics of 35 HL-women and 64 HL-men were assessed. In addition a sex specific analysis of metabolic and nutritional habits of HL-patients with prediabetes (HL-IGR) was done. Results. HL-women were older and had favourable concentrations of high density lipoprotein cholesterol (HDL-cholesterol), triglycerides (TG), and triglyceride/HDL-cholesterol ratio (TG/HDL-ratio) but were also shown to have higher concentrations of lipoprotein-a compared to HL-men...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27890513/therapeutic-effect-of-immunoadsorption-and-subsequent-immunoglobulin-substitution-in-patients-with-dilated-cardiomyopathy-results-from-the-observational-prospective-bad-berka-registry
#19
Marc-Alexander Ohlow, Michele Brunelli, Matthias Schreiber, Bernward Lauer
BACKGROUND: Elimination of cardiac autoantibodies, frequently detected in patients with dilated cardiomyopathy (DCM), with immunoadsorption (IA) improves functional capacity and left ventricular (LV) function. This study aimed to prospectively address this issue in a large cohort of unselected patients. METHODS: Consecutive patients undergoing IA followed by IgG substitution were included. Clinical and echocardiographic parameters were assessed at baseline (BL) and 12-month follow-up (FU)...
February 2017: Journal of Cardiology
https://www.readbyqxmd.com/read/27889914/predictors-of-long-term-mortality-in-older-patients-hospitalized-for-acutely-decompensated-heart-failure-clinical-relevance-of-natriuretic-peptides
#20
Andrea Passantino, Piero Guida, Rocco Lagioia, Enrico Ammirati, Fabrizio Oliva, Maria Frigerio, Domenico Scrutinio
BACKGROUND: Acute heart failure is a common cause of hospitalization among older patients. Optimized risk stratification might improve the outcome for this subgroup of patients. Natriuretic peptides have been used in the diagnosis of heart failure and in evaluating the prognosis of patients hospitalized for heart failure. However, their utility in the elderly is still controversial. OBJECTIVE: To evaluate long-term survival and prognostic factors for elderly patients hospitalized for acutely decompensated heart failure and evaluate the prognostic utility of NT-proBNP...
November 27, 2016: Journal of the American Geriatrics Society
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