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https://www.readbyqxmd.com/read/28622591/targeting-proinflammatory-cytokines-oxidative-stress-tgf-%C3%AE-1-and-stat-3-by-rosuvastatin-and-ubiquinone-to-ameliorate-trastuzumab-cardiotoxicity
#1
Ahmed M Kabel, Abeer A Elkhoely
The aim of this study was to assess the possible modulatory effects of rosuvastatin and/or ubiquinone on trastuzumab (TRZ)-induced cardiotoxicity in mice. One hundred and twenty mice were divided into six equal groups as follows: control group; TRZ group; TRZ+carboxymethyl cellulose group; TRZ+rosuvastatin group; TRZ+Ubiquinone group and TRZ+rosuvastatin+Ubiquinone group. Serum creatine kinase (CK-MB), lactate dehydrogenase (LDH), troponin I and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) were measured...
June 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28610944/bilateral-leg-oedema-after-bariatric-surgery-a-selenium-deficient-cardiomyopathy
#2
Pierre-Laurent Massoure, Olivier Camus, Laurent Fourcade, Fabrice Simon
This report describes a case of selenium-deficient cardiomyopathy secondary to bariatric surgery (Roux-en-Y gastric bypass surgery). A 40 year-old woman presented with bilateral leg oedema nine months after the surgical procedure. Timely diagnosis of selenium-deficient cardiomyopathy was due to the recognition of symptoms of heart failure, increased NT pro-BNP level, detection of myocardial diastolic dysfunction and impaired left ventricular global longitudinal strain by echocardiography, and early identification of selenium deficiency...
June 10, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28600804/noninvasive-pulmonary-transit-time-a-new-parameter-for-general-cardiac-performance
#3
Anouk G W de Lepper, Ingeborg H F Herold, Salvatore Saporito, R Arthur Bouwman, Massimo Mischi, Hendrikus H M Korsten, Koen D Reesink, Patrick Houthuizen
INTRODUCTION: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT). METHODS: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)≤35% and QRS≥120 ms...
June 9, 2017: Echocardiography
https://www.readbyqxmd.com/read/28595171/serum-irisin-predicts-mortality-risk-in-acute-heart-failure-patients
#4
Shutong Shen, Rongrong Gao, Yihua Bei, Jin Li, Haifeng Zhang, Yanli Zhou, Wenming Yao, Dongjie Xu, Fang Zhou, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Yongqin Li, Junjie Xiao, Xinli Li
BACKGROUND/AIMS: Irisin is a peptide hormone cleaved from a plasma membrane protein fibronectin type III domain containing protein 5 (FNDC5). Emerging studies have indicated association between serum irisin and many major chronic diseases including cardiovascular diseases. However, the role of serum irisin as a predictor for mortality risk in acute heart failure (AHF) patients is not clear. METHODS: AHF patients were enrolled and serum was collected at the admission and all patients were followed up for 1 year...
June 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28587950/anemia-considerations-when-assessing-natriuretic-peptide-levels-in-ed-patients
#5
Inanc Karakoyun, Ayfer Colak, Fatma Demet Arslan, Aybike Gunaslan Hasturk, Can Duman
INTRODUCTION: The incidence of heart failure (HF) has reached epidemic levels in western populations, and the majority of these patients are admitted to hospitals through the emergency department (ED). We aimed to aid clinicians assessing natriuretic peptide (NP) levels in cases with suspected HF. In this study, we investigated the effect of anemia on amino-terminal pro-BNP (NT-proBNP) and on B-type natriuretic peptide (BNP) levels. METHODS: This retrospective study examined patients who were admitted to the ED with suspected HF...
May 31, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28582641/abo-blood-groups-a-risk-factor-for-left-atrial-and-left-atrial-appendage-thrombogenic-milieu-in-patients-with-non-valvular-atrial-fibrillation
#6
Yuan Fu, Kuibao Li, Xinchun Yang
BACKGROUND: Previous studies have identified ABO blood groups as predictors of thromboembolic diseases. In patients with atrial fibrillation (AF), however, potential association between ABO blood groups and the risk of left atrial (LA) and/or left atrial appendage (LAA) thrombogenic milieu (TM) has not been established. METHODS: This is a retrospective case-control study that included 125 consecutive patients with non-valvular atrial fibrillation (NVAF) plus TM, as evidenced by transesophageal echocardiography (TEE) during a period from1 January 2010 to 31 December 2016...
May 20, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28567700/different-impact-of-aortic-regurgitation-assessed-by-aortic-root-angiography-after-transcatheter-aortic-valve-implantation-according-to-baseline-left-ventricular-ejection-fraction-and-n-terminal-pro-b-type-natriuretic-peptide
#7
Hidehiro Kaneko, Frank Hoelschermann, Thomas Schau, Grit Tambor, Michael Neuss, Christian Butter
Transcatheter aortic valve implantation (TAVI) is an alternative therapeutic option for severe aortic stenosis. Aortic regurgitation (AR) is commonly observed after TAVI and increases the mortality rate. We hypothesized that the influence of significant AR, defined as that more severe than mild AR, on survival rate after TAVI might differ according to the baseline left ventricular ejection fraction (LVEF) and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) level. We categorized 856 patients who underwent transfemoral TAVI into 2 groups according to their baseline LVEF (<40 and ≥40%) and NT-pro BNP levels (≤5000 and >5000 pg/mL)...
May 31, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28540276/plasmatic-levels-of-n-terminal-pro-bnp-in-elderly-patients-with-atrial-fibrillation-and-heart-failure-with-preserved-ejection-fraction
#8
Vasile Mircea Zăgreanu, Dana Pop, Mihnea Zdrenghea, Adela Sitar-Taut, Bogdan Caloian, Dumitru Tudor Zdrenghea
No abstract text is available yet for this article.
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28458528/significance-of-nt-pro-bnp-in-acute-exacerbation-of-copd-patients-without-underlying-left-ventricular-dysfunction
#9
Muhammad Adrish, Varalaxmi Bhavani Nannaka, Edison J Cano, Bharat Bajantri, Gilda Diaz-Fuentes
BACKGROUND: B-type natriuretic peptide (BNP) and the N-terminal fragment of pro-BNP (NT-pro-BNP) are established biomarkers of heart failure. Increased levels of natriuretic peptide (NP) have been associated with poor outcomes in acute exacerbation of COPD (AECOPD); however, most studies did not address the conditions that can also increase NT-pro-BNP levels. We aimed to determine if NT-pro-BNP levels correlate with outcomes of AECOPD in patients without heart failure and other conditions that can affect NT-pro-BNP levels...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28455084/recipient-umbilical-artery-elongation-redundancy-in-twin-twin-transfusion-syndrome
#10
Roopali Donepudi, Lovepreet K Mann, Christoph Wohlmuth, Anthony Johnson, Michael W Bebbington, Kenneth J Moise, David S Boudreaux, Helena Gardiner, Ramesha Papanna
BACKGROUND: Chronic hypertension in adults causes arterial lengthening in major arteries, but the effects of early fetal hypertension on the twin-twin transfusion syndrome recipient's vascular architecture remains unknown. OBJECTIVE: We hypothesize that arterial cord redundancy is related to recipient hypertension and subsequent heart failure. Our objectives were to: (1) establish a 3-dimensional color Doppler ultrasound method of measuring umbilical arterial length relative to its corresponding venous segment in the umbilical cord using artery vein angle; (2) compare recipient artery vein angle to gestational age-matched controls; and (3) test the association of artery vein angle with recipient heart failure...
April 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28450649/validity-and-reliability-of-the-indonesian-version-of-sf-36-quality-of-life-questionnaire-on-patients-with-permanent-pacemakers
#11
Simon Salim, Muhammad Yamin, Idrus Alwi, Siti Setiati
AIM: to construct and validate Indonesian version of SF-36. METHODS: this is a cross-sectional study, which consist of 2 stages process: 1) language and cultural adaption; and 2) validity and reliability evaluation. We evaluated 32 pacemaker patients during language and cultural adaptation stage and 20 pacemaker patients during validity and reliability evaluation stages from September 2014 to August 2015. We followed cross-cultural adaptation guideline to produce Indonesian version of the questionnaire...
January 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28429125/low-plasma-homoarginine-concentration-is-associated-with-high-rates-of-all-cause-mortality-in-renal-transplant-recipients
#12
Arslan Arinc Kayacelebi, Isidor Minović, Erik Hanff, Anne-Roos S Frenay, Martin H de Borst, Martin Feelisch, Harry van Goor, Stephan J L Bakker, Dimitrios Tsikas
In renal transplant recipients (RTR), we recently found that low urinary excretion of homoarginine (hArg) is associated with mortality and graft failure. However, it is not known whether such prospective associations also hold true for plasma concentrations of hArg. In the present study, we therefore determined plasma concentrations of hArg in the same cohort, i.e. in 687 RTR (functioning graft ≥1 year), and in 140 healthy donors, before and after kidney donation. Plasma hArg concentrations were significantly lower in RTR compared to healthy controls [1...
April 20, 2017: Amino Acids
https://www.readbyqxmd.com/read/28425226/a-review-of-pediatric-pulmonary-hypertension-with-new-guidelines
#13
Serdar Kula, Ayhan Pektaş
This study aims to review pediatric pulmonary hypertension (PH) by comparing the guidelines of the European Society of Cardiology (ESC)/European Respiratory Society (ERS), the American Heart Association (AHA)/American Thoracic Society (ATS), and the European Pediatric Pulmonary Vascular Disease Network (EPPVDN). All three sets of guidelines define PH as having a mean pulmonary artery pressure of ≥25 mmHg and accept the validity of the World Health Organization (WHO) classification system. Every child with a high index of suspicion for PH should undergo an initial work-up of chest X-rays, electrocardiography, and echocardiography...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28417288/troponin-t-elevation-after-permanent-pacemaker-implantation
#14
Xueying Chen, Ziqing Yu, Jin Bai, Shulan Hu, Wei Wang, Shengmei Qin, Jingfeng Wang, Zhe Sun, Yangang Su, Junbo Ge
PURPOSE: The objective of the study is to study the incidence, significance, and factors associated with cardiac troponin T (CTNT) elevation after pacemaker implantation. METHODS: Three hundred seventy-four patients (104 single-chamber pacemakers or ICD, 243 dual-chamber pacemakers, and 27 cardiac resynchronization therapy/cardiac resynchronization therapy defibrillator) who had normal levels of CTNT at baseline and underwent implantation of a permanent pacemaker system were included in this study...
April 18, 2017: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/28395286/heart-failure-with-preserved-and-reduced-ejection-fraction-in-hemodialysis-patients-prevalence-disease-prediction-and-prognosis
#15
Marlies Antlanger, Stefan Aschauer, Chantal Kopecky, Manfred Hecking, Johannes J Kovarik, Johannes Werzowa, Julia Mascherbauer, Bernd Genser, Marcus D Säemann, Diana Bonderman
BACKGROUND/AIMS: Heart failure (HF) is a main cause of mortality of hemodialysis (HD) patients. While HF with reduced ejection fraction (HFrEF) is known to only affect a minority of patients, little is known about the prevalence, associations with clinical characteristics and prognosis of HF with preserved ejection fraction (HFpEF). METHODS: We included 105 maintenance HD patients from the Medical University of Vienna into this prospective single-center cohort study and determined the prevalence of HFpEF (per the 2013 criteria of the European Society of Cardiology) and HFrEF (EF <45%), using standardized post-HD transthoracic echocardiography...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28394002/supplementation-with-omega-3-acids-after-myocardial-infarction-and-modification-of-inflammatory-markers-in-light-of-the-patients-diet-a-preliminary-study
#16
Magdalena Makarewicz-Wujec, Gabriela Parol, Andrzej Parzonko, Małgorzata Kozłowska-Wojciechowska
BACKGROUND: Neuroendocrine activation, activation of proinflammatory cytokines and platelets, and endothelial dysfunction play a significant role in development of heart failure. AIM: The aim of the work was to assess the effect of supplementation with EPA and DHA in adaily dose of 1g on selected inflammatory markers and platelet activation in patients with heart failure after recent myocardial infarction in light of their diet. M ETHODS: This preliminary study was arandomised, double-blind trial involving 30patients with post-infarction heart failure...
April 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28387919/the-assessment-of-the-long-term-effects-of-elective-crt-d-of-coronary-heart-disease-after-pci
#17
K Liu, B-T Hua, T Guo, L-J Pu
OBJECTIVE: The present study was planned to evaluate the long-term effects of elective cardiac resynchronization therapy devices (CRT-D) of coronary heart disease after percutaneous coronary intervention (PCI). PATIENTS AND METHODS: We continuously selected 124 patients with chronic stable heart failure to undergo PCI, and were randomly divided into two groups viz. control group with 72 cases and observation group with 52 cases. The control group was given intensive drugs, while the observation group was treated with a combination of intensive drugs with CRT-D...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28370416/right-ventricular-function-and-n-terminal-pro-brain-natriuretic-peptide-levels-in-adult-patients-with-simple-dextro-transposition-of-the-great-arteries
#18
Efrén Martínez-Quintana, Natalia Marrero-Negrín, Silvia Gopar-Gopar, Fayna Rodríguez-González
INTRODUCTION: Dextro-transposition of the great arteries (d-TGA) patients is at high risk of developing right ventricular dysfunction and tricuspid regurgitation in adulthood. Determining the relation between echocardiographic parameters, N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels and the New York Heart Association (NYHA) functional class may help determining the best time to operate them. METHODS: Patients with simple d-TGA operated in infancy with an atrial switch procedure (Mustard or Senning operation) were followed up in our Adult Congenital Heart Disease Unit...
March 29, 2017: Echocardiography
https://www.readbyqxmd.com/read/28352338/evaluation-of-safety-and-efficacy-of-elective-pci-in-patients-with-cardiac-insufficiency
#19
Jiang-Xin Jing, Xiao-Lan Zhong, Sheng-Guo Chen
We analyzed the safety and the efficacy of the treatment with elective percutaneous coronary intervention (PCI) in patients with coronary heart disease complicated with cardiac insufficiency. We enrolled 217 patients diagnosed with chronic ischemic heart disease complicated with cardiac failure. According to the type of treatment they received, patients were divided into 3 groups: i) The conservative treatment group with 60 patients (they received standard medication); ii) the early PCI group with 82 cases (their condition was stabilized, surgical risk was assessed and PCI was taken as early as possible); and iii) the advanced PCI group with 75 cases (ischemic myocardium was corrected and then elective PCI was applied and for aggravated myocardial ischemia cases, PCI was applied after assessing the risk of surgery)...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28341776/an-nppb-promoter-polymorphism-associated-with-elevated-n-terminal-pro-b-type-natriuretic-peptide-and-lower-blood-pressure-hypertension-and-mortality
#20
Sara B Seidelmann, Orly Vardeny, Brian Claggett, Bing Yu, Amil M Shah, Christie M Ballantyne, Elizabeth Selvin, Calum A MacRae, Eric Boerwinkle, Scott D Solomon
BACKGROUND: Elevated B-type natriuretic peptide (BNP) levels are associated with heart failure and increased mortality in the general population. We investigated rs198389, a functional variant in the promoter region of the BNP gene (NPPB), in patients from the Atherosclerosis Risk in Communities Study to investigate associations with N-terminal pro-BNP (NT-proBNP) levels and outcomes. METHODS AND RESULTS: A total of 11 361 black and white patients with rs198389 genotyping attended visit 1 (aged 45-64 years; 1987-1989), with follow-up visits occurring every 3 years (visit 2-visit 4, 1990-1999), followed by visit 5 (2011-2013)...
March 24, 2017: Journal of the American Heart Association
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