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https://www.readbyqxmd.com/read/28777138/high-serum-bilirubin-levels-nt-pro-bnp-and-lactate-predict-mortality-in-long-term-severely-ill-respiratory-extracorporeal-membrane-oxygenation-patients
#1
Franziska Kaestner, Daniel Rapp, Franziska C Trudzinski, Nicole Olewczynska, Stefan Wagenpfeil, Frank Langer, Monika Flaig, Heinrike Wilkens, Robert Bals, Matthias Klingele, Christian Lensch, Sebastian Fähndrich, Philipp M Lepper
Mortality in patients treated with extracorporeal membrane oxygenation (ECMO) is high. Therefore, it is crucial to better understand conditions that are associated with mortality in ECMO patients. In this retrospective analysis, we observed 51 patients treated with high-flow ECMO in 2013 and 2014 at our center. We recorded laboratory values and intensive care procedures. The hypothesis of bilirubin being a predictor of mortality during ECMO treatment was initially addressed. Therefore, laboratory values were obtained before initiation and at the time of highest bilirubin throughout the procedure...
August 2, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28772032/differentiating-heart-failure-phenotypes-using-sex-specific-transcriptomic-and-proteomic-biomarker-panels
#2
Mustafa Toma, George J Mak, Virginia Chen, Zsuzsanna Hollander, Casey P Shannon, Karen K Y Lam, Raymond T Ng, Scott J Tebbutt, Janet E Wilson-McManus, Andrew Ignaszewski, Todd Anderson, Jason R B Dyck, Jonathan Howlett, Justin Ezekowitz, Bruce M McManus, Gavin Y Oudit
AIMS: Heart failure with preserved ejection fraction (HFpEF) accounts for 30-50% of patients with heart failure (HF). A major obstacle in HF management is the difficulty in differentiating between HFpEF and heart failure with reduced ejection fraction (HFrEF) using conventional clinical and laboratory investigations. The aim of this study is to develop robust transcriptomic and proteomic biomarker signatures that can differentiate HFpEF from HFrEF. METHODS AND RESULTS: A total of 210 HF patients were recruited in participating institutions from the Alberta HEART study...
August 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28767656/collagen-turnover-biomarkers-and-systemic-right-ventricle-remodeling-in-adults-with-previous-atrial-switch-procedure-for-transposition-of-the-great-arteries
#3
Magdalena Lipczyńska, Piotr Szymański, Magdalena Kumor, Anna Klisiewicz, Piotr Hoffman
BACKGROUND: Myocardial fibrosis is a potential pathophysiological mechanism leading to systemic right ventricular (SRV) deterioration. We hypothesize that circulating levels of collagen deposition markers are elevated in patients with SRV remodeling and this elevation may have a predictive value. METHODS: We prospectively evaluated 56 patients with D-TGA after the atrial switch procedure (mean age 25.6 ± 4.8, range 18-37 years; 67% males). Serum levels of procollagen type III amino-terminal propeptide (PIIINP), collagen type I carboxy-terminal telopeptide (CITP), procollagen type I N-terminal propeptide (PINP), matrix metalloproteinase (MMP 1, MMP 9) and a tissue inhibitor of matrix metalloproteinase (TIMP 1) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) were measured and compared with healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28725213/can-brain-natriuretic-peptides-and-osteoprotegerin-serve-as-biochemical-markers-for-the-detection-of-aortic-pathology-in-children-and-adolescents-with-turner-syndrome
#4
REVIEW
Meenal Mavinkurve, Clodagh S O'Gorman
Turner syndrome (TS) is a chromosomal disorder that affects 1:2,000 females. It results from either the complete or partial loss of the X chromosome as well as other aberrations. Clinical features of TS include short stature, delayed puberty, and congenital cardiac malformations. TS children also have an increased prevalence of cardiometabolic risk factors, which predisposes them to complications like coronary artery disease, cerebrovascular-related deaths, and aortic dissection. Early cardiac imaging, such as echocardiography and cardiac magnetic resonance imaging, are recommended to detect underlying aortic pathology...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28710072/circulating-acylcarnitine-profile-in-human-heart-failure-a-surrogate-of-fatty-acid-metabolic-dysregulation-in-mitochondria-and-beyond
#5
Matthieu Ruiz, Francois Labarthe, Annik Fortier, Bertrand Bouchard, Julie Thompson Legault, Virginie Bolduc, Odile Rigal, Jane Chen, Anique Ducharme, Peter A Crawford, Jean-Claude Tardif, Christine Des Rosiers
Heart failure (HF) is associated with metabolic perturbations, particularly of fatty acids (FA), which remain to be better understood in humans. This study aimed at testing the hypothesis that HF patients with reduced ejection fraction, display systemic perturbations in levels of energy-related metabolites, especially those reflecting dysregulation of FA metabolism, namely acylcarnitines (ACs). Circulating metabolites were assessed using mass spectrometry (MS)-based methods in two cohorts. The main cohort consisted of 72 controls and 68 HF patients, exhibiting depressed left ventricular ejection fraction (25...
July 14, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28705554/atrial-function-atrial-volume-and-cardiovascular-clinical-outcomes-in-patients-with-end-stage-renal-disease-a-study-of-cardiac-computed-tomography
#6
Laust Dupont, Simon Winther, Hanne Skou Jørgensen, Peter Bomholt, Hans Erik Bøtker, Morten Bøttcher, Per Ivarsen, My Svensson
BACKGROUND: Patients with chronic kidney disease (CKD) have an increased risk of cardiovascular events. Previous studies using 2-dimensional echocardiography show that left atrial end-diastolic volume (LAEDV) predicts cardiovascular outcomes and mortality in patients with CKD. However, contrast-enhanced cardiac CT may offers a more precise measure of atrial dimensions and function than 2-dimensional echocardiography and may provide improved predictionof patient outcome. AIM: The aim of the present study was to examine the association of LAEDV and left atrial ejection fraction (LAEF) assessed by CT with left ventricle end-diastolic volume (LVEDV), left ventricular mass, left ventricular ejection fraction and N-terminal plasma-pro-brain natriuretic peptide (NT-PRO-BNP)...
July 4, 2017: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/28697773/efficacy-and-safety-of-electroacupuncture-in-acute-decompensated-heart-failure-a-study-protocol-for-a-randomized-patient-and-assessor-blinded-sham-controlled-trial
#7
Jungtae Leem, Seung Min Kathy Lee, Jun Hyeong Park, Suji Lee, Hyemoon Chung, Jung Myung Lee, Weon Kim, Sanghoon Lee, Jong Shin Woo
BACKGROUND: The purpose of this trial is to evaluate the effectiveness and safety of electroacupuncture in the treatment of acute decompensated heart failure compared with sham electroacupuncture. METHODS: This protocol is for a randomized, sham controlled, patient- and assessor-blinded, parallel group, single center clinical trial that can overcome the limitations of previous trials examining acupuncture and heart failure. Forty-four acute decompensated heart failure patients admitted to the cardiology ward will be randomly assigned into the electroacupuncture treatment group (n = 22) or the sham electroacupuncture control group (n = 22)...
July 11, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28679558/effect-modification-of-chronic-kidney-disease-on-the-association-of-circulating-and-imaging-cardiac-biomarkers-with-outcomes
#8
L Parker Gregg, Beverley Adams-Huet, Xilong Li, Gates Colbert, Nishank Jain, James A de Lemos, S Susan Hedayati
BACKGROUND: Cardiac troponin T and brain natriuretic peptide (BNP) are elevated in >50% of dialysis patients and are associated with poor outcomes. Few data investigated these associations in earlier chronic kidney disease (CKD). METHODS AND RESULTS: We studied whether CKD modified associations of elevated BNP, N-terminal-pro-BNP, high-sensitivity cardiac troponin T, coronary artery calcification, and left ventricular hypertrophy with all-cause death and cardiovascular death/events in 3218 multiethnic individuals followed for 12...
July 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28664901/corrigendum-n-terminal-pro-b-type-natriuretic-peptide-nt-pro-bnp-based-score-can-predict-in-hospital-mortality-in-patients-with-heart-failure
#9
Ya-Ting Huang, Yuan-Teng Tseng, Tung-Wei Chu, John Chen, Min-Yu Lai, Woung-Ru Tang, Chih-Chung Shiao
This corrects the article DOI: 10.1038/srep29590.
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28652105/pharmacokinetic-pharmacodynamic-and-antihypertensive-effects-of-the-neprilysin-inhibitor-lcz-696-sacubitril-valsartan
#10
REVIEW
Steven G Chrysant
LCZ-696, sacubitril/valsartan, is a dual-acting molecule consisting of the angiotensin II (Ang II) receptor blocker valsartan and the neprilysin (neutral endopeptidase) inhibitor AHU-377 with significant beneficial effects in patients with hypertension and heart failure (HF). Several recent studies have demonstrated a higher effectiveness of LCZ-696 compared to valsartan in the treatment of hypertension and HF. The rationale for the development and the Food and Drug Administration approval of LCZ-696 was based on the concept of an additive effect of the Ang II receptor blocker valsartan and the neutral endopeptidase (neprilysin) inhibitor AHU-377 for the treatment of hypertension and HF...
July 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28637626/chromosome-4q25-variants-and-recurrence-after-second-generation-cryoballoon-ablation-in-patients-with-paroxysmal-atrial-fibrillation
#11
Shinsuke Miyazaki, Yusuke Ebana, Lian Liu, Hiroaki Nakamura, Hitoshi Hachiya, Hiroshi Taniguchi, Takamitsu Takagi, Takatsugu Kajiyama, Tomonori Watanabe, Miyako Igarashi, Shigeki Kusa, Takashi Niida, Yoshito Iesaka, Tetsushi Furukawa
BACKGROUND: Chromosome 4q25 single-nucleotide polymorphisms (SNPs) are associated with atrial fibrillation (AF) recurrence after radiofrequency catheter ablation, however the underlying mechanism is unknown. Pulmonary vein (PV) reconnections are common post-radiofrequency ablation. We explored the pre-procedural parameters, including AF susceptibility SNPs, predicting the response to PV isolation (PVI) using second-generation cryoballoons. METHODS: One hundred fifty-seven paroxysmal AF patients undergoing PVI using second-generation cryoballoons and genetic testing were enrolled...
June 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28622591/targeting-proinflammatory-cytokines-oxidative-stress-tgf-%C3%AE-1-and-stat-3-by-rosuvastatin-and-ubiquinone-to-ameliorate-trastuzumab-cardiotoxicity
#12
Ahmed M Kabel, Abeer A Elkhoely
The aim of this study was to assess the possible modulatory effects of rosuvastatin and/or ubiquinone on trastuzumab (TRZ)-induced cardiotoxicity in mice. One hundred and twenty mice were divided into six equal groups as follows: control group; TRZ group; TRZ+carboxymethyl cellulose group; TRZ+rosuvastatin group; TRZ+Ubiquinone group and TRZ+rosuvastatin+Ubiquinone group. Serum creatine kinase (CK-MB), lactate dehydrogenase (LDH), troponin I and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) were measured...
September 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28610944/bilateral-leg-oedema-after-bariatric-surgery-a-selenium-deficient-cardiomyopathy
#13
Pierre-Laurent Massoure, Olivier Camus, Laurent Fourcade, Fabrice Simon
This report describes a case of selenium-deficient cardiomyopathy secondary to bariatric surgery (Roux-en-Y gastric bypass surgery). A 40 year-old woman presented with bilateral leg oedema nine months after the surgical procedure. Timely diagnosis of selenium-deficient cardiomyopathy was due to the recognition of symptoms of heart failure, increased NT pro-BNP level, detection of myocardial diastolic dysfunction and impaired left ventricular global longitudinal strain by echocardiography, and early identification of selenium deficiency...
June 10, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28600804/noninvasive-pulmonary-transit-time-a-new-parameter-for-general-cardiac-performance
#14
Anouk G W de Lepper, Ingeborg H F Herold, Salvatore Saporito, R Arthur Bouwman, Massimo Mischi, Hendrikus H M Korsten, Koen D Reesink, Patrick Houthuizen
INTRODUCTION: Pulmonary transit time (PTT) assessed with contrast-enhanced ultrasound (CEUS) is a novel tool to evaluate cardiac function. PTT represents the time for a bolus of contrast to pass from the right to the left ventricle, measured according to the indicator dilution principles using CEUS. We investigated the hypothesis that PTT is a measure of general cardiac performance in patient populations eligible for cardiac resynchronization therapy (CRT). METHODS: The study population consisted of heart failure patients referred for CRT with NYHA class II-IV, left ventricular ejection fraction (LVEF)≤35% and QRS≥120 ms...
June 9, 2017: Echocardiography
https://www.readbyqxmd.com/read/28595171/serum-irisin-predicts-mortality-risk-in-acute-heart-failure-patients
#15
Shutong Shen, Rongrong Gao, Yihua Bei, Jin Li, Haifeng Zhang, Yanli Zhou, Wenming Yao, Dongjie Xu, Fang Zhou, Mengchao Jin, Siqi Wei, Kai Wang, Xuejuan Xu, Yongqin Li, Junjie Xiao, Xinli Li
BACKGROUND/AIMS: Irisin is a peptide hormone cleaved from a plasma membrane protein fibronectin type III domain containing protein 5 (FNDC5). Emerging studies have indicated association between serum irisin and many major chronic diseases including cardiovascular diseases. However, the role of serum irisin as a predictor for mortality risk in acute heart failure (AHF) patients is not clear. METHODS: AHF patients were enrolled and serum was collected at the admission and all patients were followed up for 1 year...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28587950/anemia-considerations-when-assessing-natriuretic-peptide-levels-in-ed-patients
#16
Inanc Karakoyun, Ayfer Colak, Fatma Demet Arslan, Aybike Gunaslan Hasturk, Can Duman
INTRODUCTION: The incidence of heart failure (HF) has reached epidemic levels in western populations, and the majority of these patients are admitted to hospitals through the emergency department (ED). We aimed to aid clinicians assessing natriuretic peptide (NP) levels in cases with suspected HF. In this study, we investigated the effect of anemia on amino-terminal pro-BNP (NT-proBNP) and on B-type natriuretic peptide (BNP) levels. METHODS: This retrospective study examined patients who were admitted to the ED with suspected HF...
May 31, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28582641/abo-blood-groups-a-risk-factor-for-left-atrial-and-left-atrial-appendage-thrombogenic-milieu-in-patients-with-non-valvular-atrial-fibrillation
#17
Yuan Fu, Kuibao Li, Xinchun Yang
BACKGROUND: Previous studies have identified ABO blood groups as predictors of thromboembolic diseases. In patients with atrial fibrillation (AF), however, potential association between ABO blood groups and the risk of left atrial (LA) and/or left atrial appendage (LAA) thrombogenic milieu (TM) has not been established. METHODS: This is a retrospective case-control study that included 125 consecutive patients with non-valvular atrial fibrillation (NVAF) plus TM, as evidenced by transesophageal echocardiography (TEE) during a period from1 January 2010 to 31 December 2016...
May 20, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28567700/different-impact-of-aortic-regurgitation-assessed-by-aortic-root-angiography-after-transcatheter-aortic-valve-implantation-according-to-baseline-left-ventricular-ejection-fraction-and-n-terminal-pro-b-type-natriuretic-peptide
#18
Hidehiro Kaneko, Frank Hoelschermann, Thomas Schau, Grit Tambor, Michael Neuss, Christian Butter
Transcatheter aortic valve implantation (TAVI) is an alternative therapeutic option for severe aortic stenosis. Aortic regurgitation (AR) is commonly observed after TAVI and increases the mortality rate. We hypothesized that the influence of significant AR, defined as that more severe than mild AR, on survival rate after TAVI might differ according to the baseline left ventricular ejection fraction (LVEF) and N-terminal pro-B-type natriuretic peptide (NT-pro BNP) level. We categorized 856 patients who underwent transfemoral TAVI into 2 groups according to their baseline LVEF (<40 and ≥40%) and NT-pro BNP levels (≤5000 and >5000 pg/mL)...
May 31, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28540276/plasmatic-levels-of-n-terminal-pro-bnp-in-elderly-patients-with-atrial-fibrillation-and-heart-failure-with-preserved-ejection-fraction
#19
Vasile Mircea Zăgreanu, Dana Pop, Mihnea Zdrenghea, Adela Sitar-Taut, Bogdan Caloian, Dumitru Tudor Zdrenghea
No abstract text is available yet for this article.
April 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28458528/significance-of-nt-pro-bnp-in-acute-exacerbation-of-copd-patients-without-underlying-left-ventricular-dysfunction
#20
Muhammad Adrish, Varalaxmi Bhavani Nannaka, Edison J Cano, Bharat Bajantri, Gilda Diaz-Fuentes
BACKGROUND: B-type natriuretic peptide (BNP) and the N-terminal fragment of pro-BNP (NT-pro-BNP) are established biomarkers of heart failure. Increased levels of natriuretic peptide (NP) have been associated with poor outcomes in acute exacerbation of COPD (AECOPD); however, most studies did not address the conditions that can also increase NT-pro-BNP levels. We aimed to determine if NT-pro-BNP levels correlate with outcomes of AECOPD in patients without heart failure and other conditions that can affect NT-pro-BNP levels...
2017: International Journal of Chronic Obstructive Pulmonary Disease
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