keyword
https://read.qxmd.com/read/38532921/determining-the-role-of-nt-probnp-levels-in-diabetic-patients-with-heart-failure-a-study-from-north-india
#1
JOURNAL ARTICLE
Merajul H Siddiqui, Ritvija Dixit, Shikha Agarwal, Subhash Chandra Jha, Harshita Khanna, Sonu Kumari Agrawal
BACKGROUND: Diabetic patients are at higher risk of cardiovascular morbidity and mortality. NT-proBNP levels measurements are useful for the assessment of risk in heart failure patients in emergency condition and give the faster result. Further, it also offers lower cost and unnecessary hospitalization and follow-up cost. The studies have shown that NT-proBNP levels are a direct predictor of outcome risk in diabetic patients with heart failure. The objective of this research was to study the role of NT-proBNP levels to determine the severity of heart failure in diabetic patients...
2024: Journal of Education and Health Promotion
https://read.qxmd.com/read/38522572/increased-systemic-levels-of-centrally-acting-b-type-natriuretic-peptide-are-associated-with-chronic-itch-of-different-types
#2
JOURNAL ARTICLE
Leigh A Nattkemper, Brian S Kim, Qai Ven Yap, Mark A Hoon, Santosh K Mishra, Gil Yosipovitch
B-Type natriuretic peptide (BNP) is an itch-selective neuropeptide that was shown to play a role in both histaminergic and non-histaminergic itch in mice. It was also shown that elevated serum BNP is linked to increased pruritus in non-diabetic hemodialysis patients. This study examined plasma BNP levels of 77 patients and N-Terminal pro-BNP (NT-proBNP) levels of 33 patients with differing types of chronic itch to see if BNP and NT-proBNP levels can correlate with itch severity. Plasma BNP and NT-proBNP levels of all itch patients correlated to itch NRS, and in particular for patients with Chronic Pruritus of Unknown Origin (CPUO)...
March 22, 2024: Journal of Investigative Dermatology
https://read.qxmd.com/read/38515444/nomogram-prediction-model-for-the-risk-of-intracranial-hemorrhagic-transformation-after-intravenous-thrombolysis-in-patients-with-acute-ischemic-stroke
#3
JOURNAL ARTICLE
Yong Ma, Dong-Yan Xu, Qian Liu, He-Cheng Chen, Er-Qing Chai
BACKGROUND: Hemorrhagic transformation (HT) after intravenous thrombolysis (IVT) might worsen the clinical outcomes, and a reliable predictive system is needed to identify the risk of hemorrhagic transformation after IVT. METHODS: Retrospective collection of patients with acute cerebral infarction treated with intravenous thrombolysis in our hospital from 2018 to 2022. 197 patients were included in the research study. Multivariate logistic regression analysis was used to screen the factors in the predictive nomogram...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38514358/lung-ultrasound-in-the-evaluation-of-pulmonary-edema-in-newborns-with-critical-congenital-heart-disease
#4
JOURNAL ARTICLE
Basak Kaya, Dilek Dilli, Yasin Sarikaya, Hasan Akduman, Rumeysa Citli, Utku A Orun, Mehmet Tasar, Aysegul Zenciroglu
BACKGROUND: Newborns with critical congenital heart disease (CCHD) with increased pulmonary blood flow (PBF) are at high risk for congestive heart failure. In this study, we aimed to evaluate the presence and degree of pulmonary edema in newborns with CCHD using lung ultrasound (LUS) during the perioperative period. METHODS: Prospective clinical trial, 44 newborn patients with CCHD were evaluated in this prospective clinical trial. LUS was repeatedly performed to determine the course of pulmonary edema during the perioperative period...
March 16, 2024: Pediatrics and Neonatology
https://read.qxmd.com/read/38508657/comparison-of-troponin-and-natriuretic-peptides-in-takotsubo-syndrome-and-acute-coronary-syndrome-a-meta-analysis
#5
JOURNAL ARTICLE
Liam Steven Couch, James W Garrard, John A Henry, Rafail A Kotronias, Bashir Alaour, Giovanni Luigi De Maria, Keith M Channon, Adrian P Banning, Alexander Richard Lyon, Michael Marber, Thomas Edward Kaier
OBJECTIVE: Takotsubo syndrome (TTS) is an acute heart failure syndrome which resembles acute coronary syndrome (ACS) at presentation. Differentiation requires coronary angiography, but where this does not occur immediately, cardiac biomarkers may provide additional utility. We performed a meta-analysis to compare troponin and natriuretic peptides (NPs) in TTS and ACS to determine if differences in biomarker profile can aid diagnosis. METHODS: We searched five literature databases for studies reporting NPs (Brain NP (BNP)/NT-pro-BNP) or troponin I/T in TTS and ACS, identifying 28 studies for troponin/NPs (5618 and 1145 patients, respectively)...
March 19, 2024: Open Heart
https://read.qxmd.com/read/38497412/biomarkers-for-predicting-atrial-fibrillation-an-explorative-sub-analysis-of-the-randomised-screen-af-trial
#6
JOURNAL ARTICLE
Katharina Schmalstieg-Bahr, David J Gladstone, Eva Hummers, Johanna Suerbaum, Jeff S Healey, Antonia Zapf, Denise Köster, Stefanie M Werhahn, Rolf Wachter
BACKGROUND: Atrial fibrillation (AF) is a common treatable risk factor for stroke. Screening for paroxysmal AF in general practice is difficult, but biomarkers might help improve screening strategies. OBJECTIVES: We investigated six blood biomarkers for predicting paroxysmal AF in general practice. METHODS: This was a pre-specified sub-study of the SCREEN-AF RCT done in Germany. Between 12/2017-03/2019, we enrolled ambulatory individuals aged 75 years or older with a history of hypertension but without known AF...
December 2024: European Journal of General Practice
https://read.qxmd.com/read/38495408/retrospective-study-on-the-short-term-efficacy-of-different-doses-of-spironolactone-in-patients-with-heart-failure-of-ischemic-cardiomyopath-and-the-influence-of-ventricular-remodeling-markers
#7
JOURNAL ARTICLE
Li Xie, Han Xiao, Maoyu Zhao, Si Tang, Youzhu Qiu
OBJECTIVE: To evaluate the impact of varying dosages of Spironolactone on the short-term effectiveness and ventricular remodeling indicators in patients with Heart Failure of Ischemic Cardiomyopathy (HFIC). METHODS: A cohort of 141 HFIC patients, admitted to our hospital between October 2018 and February 2023, were enrolled for this study. Alongside the standard treatment for Chronic Congestive Heart Failure (CHF), these patients were randomly assigned to either a low-dose (20 mg/d, N=70) or a high-dose (60 mg/d, N=71) Spironolactone group...
2024: American Journal of Cardiovascular Disease
https://read.qxmd.com/read/38488713/preliminary-report-of-extracorporeal-blood-purification-therapy-in-patients-receiving-lvad-cytosorb-or-jafron-ha330
#8
RANDOMIZED CONTROLLED TRIAL
Zhuldyz Nurmykhametova, Timur Lesbekov, Rymbay Kaliyev, Bolat Bekishev, Nilufar Jabayeva, Svetlana Novikova, Linar Faizov, Ivan Vakhrushev, Yuriy Pya
BACKGROUND: Left ventricular assist device (LVAD) candidates are at increased risk of immune dysregulation and infectious complications. To attenuate the elevated proinflammatory cytokine levels and associated adverse clinical outcomes, it has been postulated that extracorporeal blood purification could improve the overall survival rate and morbidity of patients undergoing LVAD implantation. METHODS: We retrospectively reviewed prospectively collected data of 15 patients who underwent LVAD implantation at our center between January 2021 and March 2022...
March 2024: Journal of Extra-corporeal Technology
https://read.qxmd.com/read/38465751/-not-available
#9
JOURNAL ARTICLE
Saoussen Antit, Ridha Fekih, Marwa Abdelhedi, Kalthoum Dridi, Elhem Boussabeh, Lilia Zakhama
INTRODUCTION: Despite different ultrasound parameters, left ventricular filling pressures (LVFP) assessment remains inconclusive in some cases. AIM: To determine the contribution of left atrial strain (LAS) in estimating LVFP in patients with exertional symptoms and preserved left ventricular ejection fraction. METHODS: This was a monocentric study, carried out in the cardiology department of the Interior Security Forces Hospital, La Marsa, between October 2021 and March 2022...
October 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38455369/sequential-neoadjuvant-chemotherapy-using-pegylated-liposomal-doxorubicin-and-cyclophosphamide-followed-by-taxanes-with-complete-trastuzumab-and-pertuzumab-treatment-for-her2-positive-breast-cancer-a-phase-ii-single-arm-study
#10
JOURNAL ARTICLE
Yaping Yang, Liang Jin, Yudong Li, Nanyan Rao, Chang Gong, Shunrong Li, Jiannan Wu, Jinghua Zhao, Linxiaoxiao Ding, Fengxia Gan, Jun Zhang, Ruifa Feng, Zhenzhen Liu, Qiang Liu
OBJECTIVE: Despite cardiotoxicity overlap, the trastuzumab/pertuzumab and anthracycline combination remains crucial due to significant benefits. Pegylated liposomal doxorubicin (PLD), a less cardiotoxic anthracycline, was evaluated for efficacy and cardiac safety when combined with cyclophosphamide and followed by taxanes with trastuzumab/pertuzumab in human epidermal growth factor receptor-2 (HER2)-positive early breast cancer (BC). METHODS: In this multicenter, phase II study, patients with confirmed HER2-positive early BC received four cycles of PLD (30-35 mg/m2 ) and cyclophosphamide (600 mg/m2 ), followed by four cycles of taxanes (docetaxel, 90-100 mg/m2 or nab-paclitaxel, 260 mg/m2 ), concomitant with eight cycles of trastuzumab (8 mg/kg loading dose, then 6 mg/kg) and pertuzumab (840 mg loading dose, then 420 mg) every 3 weeks...
February 29, 2024: Chinese Journal of Cancer Research
https://read.qxmd.com/read/38443793/global-longitudinal-strain-and-plasma-biomarkers-for-prognosis-in-heart-failure-complicated-by-diabetes-a-prospective-observational-study
#11
JOURNAL ARTICLE
Nithin R Iyer, Siew-Pang Chan, Oi Wah Liew, Jenny P C Chong, Jennifer A Bryant, Thu-Thao Le, Chanchal Chandramouli, Patrick J Cozzone, Frank Eisenhaber, Roger Foo, A Mark Richards, Carolyn S P Lam, Martin Ugander, Calvin W-L Chin
BACKGROUND: Heart failure (HF) and diabetes are associated with increased incidence and worse prognosis of each other. The prognostic value of global longitudinal strain (GLS) measured by cardiovascular magnetic resonance (CMR) has not been established in HF patients with diabetes. METHODS: In this prospective, observational study, consecutive patients (n = 315) with HF underwent CMR at 3T, including GLS, late gadolinium enhancement (LGE), native T1, and extracellular volume fraction (ECV) mapping...
March 5, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38440820/plasma-proteomic-signature-of-human-longevity
#12
JOURNAL ARTICLE
Xiaojuan Liu, Gisli Thor Axelsson, Anne B Newman, Bruce M Psaty, Robert M Boudreau, Chenkai Wu, Alice M Arnold, Thor Aspelund, Thomas R Austin, Julius M Gardin, Kristin Siggeirsdottir, Russell P Tracy, Robert E Gerszten, Lenore J Launer, Lori L Jennings, Vilmundur Gudnason, Jason L Sanders, Michelle C Odden
The identification of protein targets that exhibit anti-aging clinical potential could inform interventions to lengthen the human health span. Most previous proteomics research has been focused on chronological age instead of longevity. We leveraged two large population-based prospective cohorts with long follow-ups to evaluate the proteomic signature of longevity defined by survival to 90 years of age. Plasma proteomics was measured using a SOMAscan assay in 3067 participants from the Cardiovascular Health Study (discovery cohort) and 4690 participants from the Age Gene/Environment Susceptibility-Reykjavik Study (replication cohort)...
March 5, 2024: Aging Cell
https://read.qxmd.com/read/38420663/real-world-diagnostic-landscape-and-incidence-of-pulmonary-hypertension-in-adult-congenital-heart-disease-patients-using-administrative-claims-data-in-japan
#13
JOURNAL ARTICLE
Tomoko Ishizu, Yasuhiro Hayashi, Natsuko Tokushige, Junichi Omura
Background: Although pulmonary hypertension (PH) and Eisenmenger's syndrome (ES) are common complications in adult congenital heart disease (ACHD), the frequency of diagnostic tests and the incidence of PH/ES in patients with ACHD in Japanese clinical practice are unclear. Therefore, we sought to clarify the frequency of diagnostic tests and incidence of PH/ES in patients with ACHD using the Medical Data Vision (MDV) database, the largest anonymized database of diagnosis procedure combination hospitals in Japan...
February 29, 2024: Current Medical Research and Opinion
https://read.qxmd.com/read/38415449/evaluation-of-urolithin-a-efficacy-in-heart-failure-patients-with-reduced-ejection-fraction-a-randomized-double-blind-crossover-placebo-controlled-clinical-trial
#14
Tannaz Jamialahmadi, Maede Hasanpour, Farveh Vakilian, Peter E Penson, Milad Iranshahy, Amirhossein Sahebkar
BACKGROUND: Mitochondrial dysfunction and impaired mitophagy are integral to myocyte loss and the progression of heart failure. Urolithin A (UA), a microbiota-produced metabolite of ellagitannins and ellagic acid, is a known stimulator of mitophagy and mitochondrial biogenesis that has shown cardioprotective effects in experimental models. METHODS: A randomized, double-blind, placebo-controlled 2×2 crossover trial was conducted on 10 patients with HF with reduced ejection fraction (HFrEF)...
February 20, 2024: Reviews on Recent Clinical Trials
https://read.qxmd.com/read/38413047/the-use-of-lung-ultrasound-in-evaluation-of-extravascular-lung-water-in-hemodialysis-patients-systematic-review-and-meta-analysis
#15
REVIEW
Anas Elgenidy, Mostafa Atef Amin, Ahmed K Awad, Abdullah Emad, Abdelrahman Nassar, Omar Alomari, Radwa Ibrahim, Faeq Husain-Syed, Mostafa G Aly
RATIONALE AND OBJECTIVES: Determining dry weight is crucial for optimizing hemodialysis, influencing efficacy, cardiovascular outcomes, and overall survival. Traditional clinical assessment methods for dry weight, relying on factors such as blood pressure and edema, frequently lack reliability. Lung ultrasound stands out as a promising tool for assessing volume status, given its non-invasiveness and reproducibility. This study aims to explore the role of Lung ultrasound in evaluating the impact of hemodialysis and ultrafiltration on extravascular lung water, with a specific focus on changes in B-lines post-hemodialysis compared to pre-hemodialysis...
February 27, 2024: Hemodialysis International
https://read.qxmd.com/read/38406646/dynamic-changes-in-cardiac-biomarkers-in-radiotherapy-for-oesophageal-cancer-and-their-correlations-with-cardiac-radiation-dosimetry
#16
JOURNAL ARTICLE
Jin-Zhi Wang, Yue Wang, Qian Shao, Jian-Bin Li
BACKGROUND AND PURPOSE: To investigate the dynamic changes in cardiac enzymes, high-sensitivity troponin T (hs-TnT), pro-brain natriuretic peptide (pro-BNP) and left ventricular ejection fraction (LVEF) during radiotherapy (RT) and 6 months after RT for oesophageal squamous cell carcinoma (ESCC) in the middle and lower locations and to analyse the correlations between these indicators and cardiac radiation dosimetry parameters. METHODS: For 35 patients with ESCC in the middle and lower locations receiving radical concurrent chemoradiotherapy (cCRT), intensity-modulated RT was performed at 1...
March 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38401102/predictive-value-of-nt-probnp-for-new-onset-atrial-fibrillation-in-the-acute-phase-of-myocardial-infarction
#17
JOURNAL ARTICLE
Zhimin Dong, Xiaoxia Hou, Caixia Guo
OBJECTIVE: The objective of this study was to assess the predictive value of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels on admission and new-onset atrial fibrillation (AF) in patients with acute myocardial infarction (AMI). METHODS: In this study, a retrospective cohort study design scheme was used to include a total of 291 consecutive patients who were hospitalized for AMI from July 2019 to May 2020, of whom 36 (12.4%) developed new-onset atrial fibrillation (AF) during their hospitalization, which was classified as the AF group, and the rest of the patients were in the non-AF group...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38398768/possible-correlations-between-mean-platelet-volume-and-biological-electrocardiographic-and-echocardiographic-parameters-in-patients-with-heart-failure
#18
JOURNAL ARTICLE
Andreea Catană, Cătălina Liliana Andrei, Suzana Guberna, Octavian Ceban, Crina Julieta Sinescu
(1) Background: Despite advancements in medical research and discoveries, heart failure (HF) still represents a significant and prevalent public health challenge. It is characterized by persistently high mortality and morbidity rates, along with increased rates of readmissions, particularly among the elderly population. (2) Methods: This study was conducted retrospectively on 260 patients with stable or decompensated chronic HF. The parameter of interest in the study population was the mean platelet volume (MPV), and the main objective of the research was to identify a possible relationship between MPV and several variables-biological (NT-proBNP, presepsin, red cell distribution width (RDW)), electrocardiographic (atrial fibrillation (AFib) rhythm, sinus rhythm (SR)), and echocardiographic (left ventricle ejection fraction (LVEF), left atrial (LA) diameter, left ventricle (LV) diameter, pulmonary hypertension (PH))...
February 16, 2024: Life
https://read.qxmd.com/read/38396869/on-whether-ca-125-is-the-answer-for-diagnosing-overhydration-particularly-in-end-stage-kidney-disease-patients-a-systematic-review
#19
REVIEW
Barbara Emilia Nikitiuk, Alicja Rydzewska-Rosołowska, Katarzyna Kakareko, Irena Głowińska, Tomasz Hryszko
Overhydration (OH) is a prevalent medical problem that occurs in patients with kidney failure, but a specific marker has still not been found. Patients requiring kidney replacement therapy suffer from a water imbalance, which is correlated with mortality rates in this population. Currently, clinicians employ techniques such as bioimpedance spectroscopy (BIS) and ultrasound (USG) markers of overhydration or markers of heart and kidney function, namely NT-pro-BNP, GFR, or creatinine levels. New serum markers, including but not limited to Ca-125, galectin-3 (Gal-3), adrenomedullin (AMD), and urocortin-2 (UCN-2), are presently under research and have displayed promising results...
February 12, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38391251/effects-of-dapagliflozin-on-cardiac-function-and-short-term-prognosis-of-patients-with-both-acute-myocardial-infarction-and-type-2-diabetes-mellitus
#20
JOURNAL ARTICLE
Le Zhou, Xiaohong Geng, Qian Hu, Jiani Gu, Yi Chen
BACKGROUND: Dapagliflozin is a selective SGLT2 inhibitor, which has been widely used in the treatment of patients with type 2 diabetes mellitus (T2DM). By blocking the reabsorption of glucose in renal tubules, daglitazine can promote urinary glucose excretion, reduce blood glucose and blood pressure, and also shows a protective effect on the heart in clinical studies. Accordingly, this study was designed to explore the effects of dapagliflozin on cardiac function and short-term prognosis of patients with acute myocardial infarction (AMI) complicated with T2DM...
February 23, 2024: Minerva cardiology and angiology
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