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infection prophylaxy surgery

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https://www.readbyqxmd.com/read/28723736/timing-of-preoperative-antibiotic-prophylaxis-in-54-552-patients-and-the-risk-of-surgical-site-infection-a-systematic-review-and-meta-analysis
#1
Stijn Willem de Jonge, Sarah L Gans, Jasper J Atema, Joseph S Solomkin, Patchen E Dellinger, Marja A Boermeester
The aim of the study was to assess the effect of timing of preoperative surgical antibiotic prophylaxis (SAP) on surgical site infection (SSI) and compare the different timing intervals.The benefit of routine use of SAP prior to surgery has long been recognized. However, the optimal timing has not been defined. For the purpose of developing recommendations for the World Health Organization guideline for SSI prevention, a systematic review and meta-analysis of all relevant evidence was conducted.Major medical databases were searched from 1990 to 2016...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28708777/intraoperative-topical-antibiotics-for-infection-prophylaxis-in-pelvic-and-acetabular-surgery
#2
Matthew T Owen, Emily M Keener, Zane B Hyde, Reaves M Crabtree, Parke W Hudson, Russell L Griffin, Jason A Lowe
OBJECTIVES: Determine if topical vancomycin and tobramycin powder reduces the incidence of surgical site infection (SSI) following pelvic ring and acetabulum fracture surgery. DESIGN: Retrospective cohort study SETTING:: University of Alabama at Birmingham, Academic Level I Trauma Center PATIENTS/PARTICIPANTS:: 219 patients (140 meeting inclusion criteria) with pelvic and acetabular fractures who underwent open reduction and internal fixation (ORIF) from March 2012 to November 2013...
June 26, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28695786/antibiotic-prophylaxis-in-clean-contaminated-head-and-neck-surgery-a-systematic-review-and-meta-analysis
#3
Peter M Vila, Joseph Zenga, Ryan S Jackson
Objective To determine the optimal duration and type of antibiotic prophylaxis in patients undergoing clean-contaminated resection for head and neck cancer. Data Sources Search strategies were created by a medical librarian, implemented in multiple databases, and completed in June 2016. Review Methods The population of interest was adults ≥18 years undergoing clean-contaminated head and neck surgery, intervention was postoperative antibiotic prophylaxis, comparator was duration and types of antibiotics used, outcome was the wound infection rate, and the study design was randomized controlled trials (RCTs)...
July 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28692690/risk-of-surgical-site-infection-acute-kidney-injury-and-clostridium-difficile-infection-following-antibiotic-prophylaxis-with-vancomycin-plus-a-beta-lactam-versus-either-drug-alone-a-national-propensity-score-adjusted-retrospective-cohort-study
#4
MULTICENTER STUDY
Westyn Branch-Elliman, John E Ripollone, William J O'Brien, Kamal M F Itani, Marin L Schweizer, Eli Perencevich, Judith Strymish, Kalpana Gupta
BACKGROUND: The optimal regimen for perioperative antimicrobial prophylaxis is controversial. Use of combination prophylaxis with a beta-lactam plus vancomycin is increasing; however, the relative risks and benefits associated with this strategy are unknown. Thus, we sought to compare postoperative outcomes following administration of 2 antimicrobials versus a single agent for the prevention of surgical site infections (SSIs). Potential harms associated with combination regimens, including acute kidney injury (AKI) and Clostridium difficile infection (CDI), were also considered...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28692521/evaluation-intravenous-drip-cephazolin-prophylaxis-of-breast-cancer-surgery-site-infection
#5
Sufang Yang, Guohua Liu, Danling Tang, De Cai
PURPOSE: The efficacy of antibiotic prophylaxis for the prevention of surgical site infection (SSI) after breast cancer surgery remains uncertain. The authors of a recent Cochrane meta-analysis based on 15 randomized trials were unable to draw a definitive conclusion. The purpose of this study was to determine the effectiveness of prophylactic antibiotics for the prevention of SSI after breast cancer surgery and the risk factors for SSI. METHODS: Breast cancer patients who underwent mastectomy at the authors' institution were enrolled in this study...
July 7, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28690040/bioactivity-of-ceftazidime-and-fluconazole-included-in-polymethyl-methacrylate-bone-cement-for-use-in-arthroplasty
#6
J Martínez-Moreno, V Merino, A Nácher, J L Rodrigo, Blanca B Bonet Yuste, M Merino-Sanjuán
BACKGROUND: The microorganisms that most frequently cause prosthetic joint infection are methicillin-resistant Staphylococcus aureus and gram-negative aerobic bacillus. Studies have documented the efficacy of mixing antibiotics with polymethyl methacrylate, but that of antifungal drugs has not received much attention. The objective of this in vitro study was to characterize the elution profile and bioactivity of ceftazidime and fluconazole when incorporated into bone cement in proportions intended for prophylaxis and treatment of bone infections...
May 4, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28677576/methods-to-reduce-postoperative-surgical-site-infections-after-head-and-neck-oncology-surgery
#7
REVIEW
Richard B Cannon, Jeffrey J Houlton, Eduardo Mendez, Neal D Futran
Head and neck cancer surgery is often a complex multi-step procedure that includes major resections, vascularised tissue reconstruction, and extensive neck dissection. The upper aerodigestive tract mucosal lining is often disrupted during surgery, which requires the management of a clean-contaminated field and the need to reconstruct the mucosal lining. With bacterial contamination, surgical site infections (SSI) are a serious complication that can result in delayed wound healing, wound breakdown, fistula formation, and compromised tissue reconstruction...
July 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28676409/enterococci-in-orthopaedic-infections-who-is-at-risk-getting-infected
#8
Ilker Uçkay, Daniela Pires, Americo Agostinho, Nastassia Guanziroli, Mehmet Öztürk, Placido Bartolone, Philippe Tscholl, Michael Betz, Didier Pittet
Some orthopaedic patients might be at risk for enterococcal infections and might benefit from adapted perioperative prophylaxis. METHODS: We performed a single-center cohort of adult patients with orthopaedic infections. RESULTS: Among 2740 infection episodes, 665 surgeries (24%) involved osteosynthesis material, including total joint arthroplasties. The recommended perioperative prophylaxis was cefuroxime (or vancomycin in case of documented MRSA body carriage)...
July 1, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28674620/risk-and-outcomes-of-aortic-valve-endocarditis-among-patients-with-bicuspid-and-tricuspid-aortic-valves
#9
Yuka Kiyota, Alessandro Della Corte, Vanessa Montiero Vieira, Karam Habchi, Chuan-Chin Huang, Ester E Della Ratta, Thoralf M Sundt, Prem Shekar, Jochen D Muehlschlegel, Simon C Body
OBJECTIVE: Patients with structural abnormalities of cardiac valves, including bicuspid aortic valve (BAV), are said to be at higher risk of infective endocarditis (IE). We sought to determine the risk of IE of the BAV compared with the tricuspid aortic valve (TAV) and to determine the risk of aortic valve replacement and mortality after IE. METHODS: From medical records of two US and one Italian hospitals, patients with their first episode of IE of any native valve were identified...
2017: Open Heart
https://www.readbyqxmd.com/read/28665245/prophylactic-use-of-intraoperative-vancomycin-powder-and-postoperative-infection-an-analysis-of-microbiological-patterns-in-1200-consecutive-surgical-cases
#10
Owoicho Adogwa, Aladine A Elsamadicy, Amanda Sergesketter, Victoria D Vuong, Ankit I Mehta, Raul A Vasquez, Joseph Cheng, Carlos A Bagley, Isaac O Karikari
OBJECTIVE Wound infections following spinal surgery for deformity place a high toll on patients, providers, and the health care system. The prophylactic application of intraoperative vancomycin powder has been shown to lower the infection risk after thoracolumbar decompression and fusion for deformity correction. The purpose of this study was to assess the microbiological patterns of postoperative surgical site infections (SSIs) after prophylactic use of vancomycin powder in adult patients undergoing spinal deformity surgery...
June 30, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28664712/comparative-study-on-usefulness-of-gentamycin-containing-collagen-implants-in-the-treatment-of-patients-with-osteitis-and-osteomyelitis-of-the-craniofacial-skeleton
#11
COMPARATIVE STUDY
Paweł J Zawadzki, Konrad Perkowski, Michał Kotlarski, Anna Pietruczuk-Padzik, Lidia Chomicz
<b>Introduction and objective.</b> A reduction in incidences of peri-surgical complications due to infections is achieved by antibiotic prophylaxis The objective of the study was to assess the usefulness of gentamycin-containing collagen implants (GCCI) in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton. <b>Materials and method.</b> The retrospective study included 103 patients with osteitis and osteomyelitis. 54 patients were treated intra-operatively with GCCI (Garamycin, EusaPharma, Europe)...
May 11, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/28663796/improving-antibiotic-prophylaxis-in-gastrointestinal-surgery-patients-a-quality-improvement-project
#12
Rabie Kilan, Dane Moran, Iyad Eid, Christopher Okeahialam, Corrine Quinn, Wadie Binsaddiq, Tammy Williams, Michael H Johnson
BACKGROUND: A surgical site infection (SSI) is a frequent complication following gastrointestinal surgery, but the careful selection and administration of prophylactic antibiotics can reduce the risk. The aim of this study was to develop a package of interventions that could be used to improve surgical antibiotic prophylaxis (SAP) at our institution. METHODS: A pre-post quality improvement project at a private hospital in Saudi Arabia was conducted between January 2014 until July 2016...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28663774/infection-prophylaxis-for-breast-implant-surgery-could-we-do-better
#13
Julia R Henderson, Sandhir Kandola, Susan P Hignett, Rebecca L Teasdale, Ashley R Topps, Mandana Pennick, Meiju Hwang, Nicola Barnes, Cliona C Kirwan
Objective: Infective complications following breast implant surgery may result in implant removal. This causes patient distress and is costly to treat. A range of precautions is undertaken at the time of surgery to reduce infection, with varying levels of supporting evidence. This study aimed to determine how frequently and consistently infection prevention precautions are used during breast implant surgery. Methods: Multicenter observational study of surgical practice with real-time data collection during breast implant surgery...
2017: Eplasty
https://www.readbyqxmd.com/read/28659322/the-effect-of-preoperative-antimicrobial-prophylaxis-on-intraoperative-culture-results-in-patients-with-a-suspected-or-confirmed-prosthetic-joint-infection-a-systematic-review
#14
Marjan Wouthuyzen-Bakker, Natividad Benito, Alex Soriano
Introduction: Obtaining reliable cultures during revision arthroplasty is important to adequately diagnose and treat a prosthetic joint infection (PJI). The influence of antimicrobial prophylaxis on culture results remains unclear. As withholding prophylaxis increases the risk for surgical site infections, clarification on this topic is critical.Material and methods: A systematic review was performed with the following research question: 'In patients who undergo revision surgery of a prosthetic joint (P), does preoperative antimicrobial prophylaxis (I) affect the culture yield (O) of intraoperative samples in comparison with non-preoperative antimicrobial prophylaxis (C)?'Results: 7 articles were included in the final analysis...
June 28, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28657405/systemic-antibiotic-prophylaxis-prior-to-gastrointestinal-surgery-is-oral-administration-of-doxycycline-and-metronidazole-adequate
#15
Anneli Giske, Linn Såve Nymo, Ole-Martin Fuskevåg, Siri Amundsen, Gunnar Skov Simonsen, Kristoffer Lassen
BACKGROUND: Antibiotic prophylaxis is recommended prior to a wide range of gastrointestinal operations to reduce the rate of surgical site infections (SSIs). Traditional intravenous (IV) drugs are costly and their preparation strains nursing resources at the wards. While oral administration may attenuate these limitations, its use remains limited. We aimed to assess whether a dual oral antibiotic prophylaxis regimen provides adequate serum concentrations throughout the surgical procedure...
June 28, 2017: Infectious Diseases
https://www.readbyqxmd.com/read/28656047/multicenter-phase-2-study-about-the-safety-of-no-antimicrobial-prophylaxis-use-in-low-risk-patients-undergoing-laparoscopic-distal-gastrectomy-for-gastric-carcinoma-ksweet-01-study
#16
Oh Jeong, Mi Ran Jung, Seong Yeob Ryu, Young-Kyu Park, Min Chan Kim, Ki Han Kim, Seung Wan Ryu, In Gyu Kwon, Young Gil Son
BACKGROUND: Recent studies have shown a lower risk of surgical site infections (SSI) after laparoscopic distal gastrectomy compared to open surgery. This is a phase 2 study aiming to determine the incidence of SSI after laparoscopic distal gastrectomy without using antimicrobial prophylaxis (AMP). METHODS: cT1N0 gastric cancers that were subject to laparoscopic distal gastrectomy were enrolled. Based on the unacceptable SSI incidence of ≥12.5% and the target SSI incidence of ≤5%, 105 patients were enrolled with an α of 0...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28645839/antibiotic-prophylaxis-adequacy-in-knee-arthroplasty-and-surgical-wound-infection-prospective-cohort-study
#17
J A Del-Moral-Luque, A Checa-García, Á López-Hualda, M C Villar-Del-Campo, J Martínez-Martín, F J Moreno-Coronas, J Montejo-Sancho, G Rodríguez-Caravaca
OBJECTIVE: Antibiotic prophylaxis is the most suitable tool for preventing surgical wound infection. This study evaluated adequacy of antibiotic prophylaxis in surgery for knee arthroplasty and its effect on surgical site infection. MATERIAL AND METHOD: Prospective cohort study. We assessed the degree of adequacy of antibiotic prophylaxis, the causes of non-adequacy, and the effect of non-adequacy on surgical site infection. Incidence of surgical site infection was studied after a maximum incubation period of a year...
June 20, 2017: Revista Española de Cirugía Ortopédica y Traumatología
https://www.readbyqxmd.com/read/28643098/-importance-of-wound-irrigation-solutions-and-fluids-with-antiseptic-effects-in-therapy-and-prophylaxis-update-2017
#18
REVIEW
Christian Willy, Catharina Scheuermann-Poley, Marcus Stichling, Thomas von Stein, Axel Kramer
INTRODUCTION: Despite the use of modern antibiotics as well as complex perioperative, intraoperative and postoperative prophylactic measures, the rate of surgical site infections (SSI) could not be significantly reduced. The introduction of biocompatible antiseptic drugs with a high microbiocidal effect provided a successful alternative for infection prevention and therapy, particularly in a time of increasing occurrence of multi-drug resistant pathogens. Hence, questions about the risk-benefit ratio of antiseptic wound irrigation solutions, the prophylactic use of wound irrigation solutions for the reduction of SSI and the effect of negative pressure wound therapy combined with instillation (NPWTi) need to be answered...
July 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28630690/incidence-and-risk-factors-for-surgical-site-infections-in-obstetric-and-gynecological-surgeries-from-a-teaching-hospital-in-rural-india
#19
Ashish Pathak, Kalpana Mahadik, Manmat B Swami, Pulak K Roy, Megha Sharma, Vijay K Mahadik, Cecilia Stålsby Lundborg
BACKGROUND: Surgical site infections (SSI) are one of the most common healthcare associated infections in the low-middle income countries. Data on incidence and risk factors for SSI following surgeries in general and Obstetric and Gynecological surgeries in particular are scare. This study set out to identify risk factors for SSI in patients undergoing Obstetric and Gynecological surgeries in an Indian rural hospital. METHODS: Patients who underwent a surgical procedure between September 2010 to February 2013 in the 60-bedded ward of Obstetric and Gynecology department were included...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/28629781/position-paper-for-the-evaluation-and-management-of-oral-status-in-patients-with-valvular-disease-groupe-de-travail-valvulopathies-de-la-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-cardiologie-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-chirurgie-orale-soci%C3%A3-t%C3%A3-fran%C3%A3-aise-de-parodontologie-et-d-implantologie
#20
REVIEW
Sarah Millot, Philippe Lesclous, Marie-Laure Colombier, Loredana Radoi, Clément Messeca, Mathieu Ballanger, Jean-Luc Charrier, Philippe Tramba, Stéphane Simon, Alain Berrebi, Fabien Doguet, Emmanuel Lansac, Christophe Tribouilloy, Gilbert Habib, Xavier Duval, Bernard Iung
Oral health is of particular importance in patients with heart valve diseases because of the risk of infective endocarditis. Recommendations for antibiotic prophylaxis before dental procedures have been restricted, but the modalities of oral evaluation and dental care are not detailed in guidelines. Therefore, a multidisciplinary working group reviewed the literature to propose detailed approaches for the evaluation and management of buccodental status in patients with valvular disease. Simple questions asked by a non-dental specialist may draw attention to buccodental diseases...
June 16, 2017: Archives of Cardiovascular Diseases
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