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https://www.readbyqxmd.com/read/29319245/cardiometabolic-risk-factors-in-acute-coronary-syndrome-with-special-reference-to-non-hdl-cholesterol
#1
Debjani S Goswami, Tanuja P Manohar
Introduction: Cardiovascular diseases are becoming the major cause of morbidity and mortality in most of the developing countries including India. Cardiometabolic risk factors play a vital role in causation of coronary artery disease. Present study was carried out to investigate the role of various risk factors in the occurrence of coronary artery disease (CAD) in population from Central India. Settings and Design: This was a hospital-based age and sex matched case-control study, carried out at Lata Mangeshkar Hospital, Nagpur...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29237072/appropriate-choice-of-stress-modality-in-patients-undergoing-myocardial-perfusion-scintigraphy-with-a-cardiac-camera-equipped-with-solid-state-detectors-the-role-of-diabetes-mellitus
#2
Alessia Gimelli, Riccardo Liga, Alberto Clemente, Emilio Maria Pasanisi, Brunella Favilli, Paolo Marzullo
Aims: To evaluate the impact of diabetes mellitus (DM) on the accuracy of myocardial perfusion scintigraphy (MPS) in detecting coronary artery disease (CAD). Methods and results: Two hundred and sixteen patients with DM and 432 matched controls were submitted to MPS on a dedicated cardiac camera equipped with cadmium-zinc-telluride (CZT) detectors and coronary angiography. Exercise stress was performed in 442 (68%) patients, while the remainders underwent vasodilator stress...
December 11, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29236974/diabetes-as-an-independent-predictor-of-left-ventricular-longitudinal-strain-reduction-at-rest-and-during-dobutamine-stress-test-in-patients-with-significant-coronary-artery-disease
#3
Karina Wierzbowska-Drabik, Ewa Trzos, Malgorzata Kurpesa, Tomasz Rechcinski, Dawid Miskowiec, Urszula Cieslik-Guerra, Barbara Uznanska-Loch, Maria Sobczak, Jaroslaw Damian Kasprzak
Aims: Diabetes (DM) is a strong cardiovascular risk factor modifying also the left ventricular (LV) function that may be objectively assessed with echocardiographic strain analysis. Although the impact of isolated DM on myocardial deformation has been already studied, few data concern diabetics with coronary artery disease (CAD), especially in all stages of dobutamine stress echocardiography (DSE). We compared LV systolic function during DSE in CAD with and without DM using state-of-the art speckle-tracking quantification and assessed the impact of DM on LV systolic strain...
December 9, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29232752/simultaneous-determination-of-rosuvastatin-rosuvastatin-5%C3%A2-s-lactone-and-n-desmethyl-rosuvastatin-in-human-plasma-by-uplc-ms-ms-and-its-application-to-clinical-study
#4
Xue Bai, Xi-Pei Wang, Guo-Dong He, Bin Zhang, Min Huang, Jia-Li Li, Shi-Long Zhong
Objective A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay was developed and validated for the simultaneous quantification of rosuvastatin (RST), rosuvastatin-5 S-lactone (RSTL), and N-desmethyl rosuvastatin (DM-RST) in human plasma. Methods Sample was prepared by liquid-liquid extraction with ethyl acetate from 100 μL acidulated buffered plasma. Then analytes were chromatographically separated using an Acquity UPLC HSS T3 column (3.0 mm×100 mm, 1...
December 12, 2017: Drug Research
https://www.readbyqxmd.com/read/29220422/atrioventricular-node-ablation-and-his-bundle-pacing
#5
Pugazhendhi Vijayaraman, Faiz A Subzposh, Angela Naperkowski
Aims: Atrioventricular node ablation (AVNA) and right ventricular pacing (RVP) are effective therapies for patients with atrial fibrillation (AF) and rapid ventricular rates. His bundle pacing (HBP) is a physiologic alternative to RVP. The aim of our study is to assess the feasibility and safety of HBP in patients undergoing AVNA and its effect on left ventricular (LV) function. Methods and results: Permanent HBP is the preferred form of ventricular pacing at our institute...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29214611/coronary-risk-equivalence-of-diabetes-assessed-by-spect-mpi
#6
Donna Chelle V Morales, Sanjeev P Bhavnani, Alan W Ahlberg, Raja C Pullatt, Deborah M Katten, Donna M Polk, Gary V Heller
BACKGROUND: Several publications and guidelines designate diabetes mellitus (DM) as a coronary artery disease (CAD) risk equivalent. The aim of this investigation was to examine DM cardiac risk equivalence from the perspective of stress SPECT myocardial perfusion imaging (MPI). METHODS AND RESULTS: We examined cardiovascular outcomes (cardiac death or nonfatal MI) of 17,499 patients referred for stress SPECT-MPI. Patients were stratified into four categories: non-DM without CAD, non-DM with CAD, DM without CAD, and DM with CAD, and normal or abnormal perfusion...
December 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29145828/long-term-prognosis-of-patients-with-non-st-segment-elevation-myocardial-infarction-according-to-coronary-arteries-atherosclerosis-extent-on-coronary-angiography-a-historical-cohort-study
#7
Karam Sadoon Alzuhairi, Peter Søgaard, Jan Ravkilde, Aziza Azimi, Michael Mæng, Lisette Okkels Jensen, Christian Torp-Pedersen
BACKGROUND: Patients with non-ST-segment elevation myocardial infarction (NSTEMI) without obstructive coronary artery disease (CAD) are often managed differently than those with obstructive CAD, therefore we aimed in this study to examine the long-term prognosis of patients with NSTEMI according to the degree of CAD on coronary angiography (CAG). METHODS: We examined 8.889 consecutive patients admitted for first time NSTEMI during 2000-2011, to whom CAG was performed...
November 16, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29121540/computer-aided-diagnosis-of-diabetic-foot-using-infrared-thermography-a-review
#8
Muhammad Adam, Eddie Y K Ng, Jen Hong Tan, Marabelle L Heng, Jasper W K Tong, U Rajendra Acharya
Diabetes mellitus (DM) is a chronic metabolic disorder that requires regular medical care to prevent severe complications. The elevated blood glucose level affects the eyes, blood vessels, nerves, heart, and kidneys after the onset. The affected blood vessels (usually due to atherosclerosis) may lead to insufficient blood circulation particularly in the lower extremities and nerve damage (neuropathy), which can result in serious foot complications. Hence, an early detection and treatment can prevent foot complications such as ulcerations and amputations...
December 1, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28989893/an-intriguing-family-with-type-2-diabetes-mellitus-and-complete-heart-block
#9
Gaurav Agarwal, Satish Kumar Singh
Chronic hyperglycaemia of Type 2 Diabetes Mellitus (T2DM) causes long term damage to heart resulting in coronary artery disease (CAD), myocardial infarction (MI), congestive heart failure (CHF), and sudden death from arrhythmias. A 62 year old male presented to our emergency with complaint of sudden onset giddiness from last 2 hours. This was followed by loss of consciousness. Patient was a known case of T2DM since last 1 year. Family history- patient has two brothers who also have T2DM and both of them also developed Complete Heart Block (CHB) spontaneously...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28988641/sex-dependent-effects-of-diabetes-mellitus-on-the-revascularization-rate-in-mid-term-follow-up-of-young-patients-with-coronary-artery-disease
#10
Masoumeh Lotfi-Tokaldany, Seyed Hesameddinn Abbasi, Abbasali Karimi, Seyed Ebrahim Kassaian, Tahereh Davarpasand, Arash Jalali, Saeed Sadeghian
AIMS: We investigated the association between Type-2 diabetes mellitus (DM) and the need for revascularization at a 5-year follow-up of young coronary artery disease patients and the role of sex in this regard. METHODS: Among 1121 young (males≤45, and females≤55years) patients (female: 49.7%) from Tehran Heart Center's Premature Coronary Atherosclerosis Cohort, 371(33.1%) had diabetes prior to angiography. Revascularization was considered as either percutaneous coronary intervention or coronary artery bypass graft surgery...
December 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28976897/glycemic-variability-and-vascular-complications-in-patients-with-type-2-diabetes-mellitus
#11
Martin Caprnda, Dasa Mesarosova, Pablo Fabuel Ortega, Boris Krahulec, Emmanuel Egom, Luis Rodrigo, Peter Kruzliak, Ioana Mozos, Ludovit Gaspar
BACKGROUND: Presence of macro- and microvascular complications in patients with diabetes mellitus (DM) is not only related to chronic hyperglycemia represented by glycated hemoglobin (HbA1c) but also to acute glycemic fluctuations (glycemic variability, GV). The association between GV and DM complications is not completely clear. Aim of our study was to evaluate GV by MAGE index in patients with type 2 DM and to verify association of MAGE index with presence of macro- and microvascular DM complications...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28969633/relation-between-low-density-lipoprotein-cholesterol-apolipoprotein-b-ratio-and-triglyceride-rich-lipoproteins-in-patients-with-coronary-artery-disease-and-type-2-diabetes-mellitus-a-cross-sectional-study
#12
Shigemasa Tani, Tsukasa Yagi, Wataru Atsumi, Kenji Kawauchi, Rei Matsuo, Atsushi Hirayama
BACKGROUND: The low-density lipoprotein cholesterol/apolipoprotein B (LDL-C/apoB) ratio has conventionally been used as an index of the LDL-particle size. Smaller LDL-particle size is associated with triglyceride (TG) metabolism disorders, often leading to atherogenesis. We investigated the association between the LDL-C/apoB ratio and TG metabolism in coronary artery disease (CAD) patients with diabetes mellitus (DM). METHODS: In the cross-sectional study, the LDL-C/apoB ratio, which provides an estimate of the LDL-particle size, was calculated in 684 consecutive patients with one additional risk factor...
October 2, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28906531/red-cell-distribution-width-is-correlated-with-extensive-coronary-artery-disease-in-patients-with-diabetes-mellitus
#13
Atac Celik, Metin Karayakali, Fatih Altunkas, Kayihan Karaman, Arif Arisoy, Koksal Ceyhan, Hasan Kadi, Fatih Koc
INTRODUCTION: Previous studies have predicted an independent relationship between red cell distribution width (RDW) and the risk of death and cardiovascular events in patients with coronary artery disease (CAD). The aim of this study was to investigate the relationship between RDW and extensiveness of CAD in patients with diabetes mellitus (DM). METHODS: Two hundred and thirty-three diabetic patients who underwent coronary angiographies at our centre in 2010 were included in the study...
August 23, 2017: Cardiovascular Journal of Africa
https://www.readbyqxmd.com/read/28871240/in-vivo-and-in-vitro-analysis-in-coronary-artery-disease-related-to-type-2-diabetes
#14
Teresa Infante, Ernesto Forte, Marco Aiello, Marco Salvatore, Carlo Cavaliere
AIM: The leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (DM) is coronary artery disease (CAD), a condition often asymptomatic but severe in these patients. Although glucose metabolism impairment and oxidative stress are known actors in the endothelial dysfunction/remodeling that occurs in diabetic patients, the relationship between cardiovascular disorders and DM is not fully understood. We have performed both an in vivo imaging and in vitro molecular analysis to investigate diabetic-specific CAD alterations...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28836572/elevated-levels-of-very-low-density-lipoprotein-cholesterol-independently-associated-with-in-stent-restenosis-in-diabetic-patients-after-drug-eluting-stent-implantation
#15
Zheng Qin, Fang-Wu Zheng, Chuang Zeng, Kuo Zhou, Yu Geng, Jian-Long Wang, Yue-Ping Li, Qing-Wei Ji, Yu-Jie Zhou
BACKGROUND: High rate of in-stent restenosis (ISR) remained an unsolved clinical problem in clinical practice, especially among patients with diabetes mellitus (DM). Diabetic patients often had hypertriglyceridemia with elevated levels of very low-density lipoprotein cholesterol (VLDL-C). Increasing evidence suggested that VLDL-C was known as a significant risk factor for atherosclerosis and had been recommended as a treatment target by current dyslipidemia guidelines. However, the role of VLDL-C in the occurrence and development of ISR in coronary artery disease (CAD) patients with DM had not been studied...
October 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28816537/evaluating-the-prescription-of-angiotensin-converting-enzyme-inhibitors-or-receptor-blockers-in-patients-with-diabetes-in-jordan
#16
Fadia Mayyas, Wa'ed Bataineh, Anan Jarab
OBJECTIVE: The angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) are guideline-recommended agents to prevent development and progression of nephropathy and cardiovascular diseases in diabetic Mellitus (DM). The aim of this study was to evaluate the prescription of ACEIs/ARBs in DM patients with guideline indications. METHOD: electronic data files for diabetes patients were retrospectively reviewed at a primary care setting northern Jordan...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28789689/impact-of-cd14-cd16-monocytes-on-plaque-vulnerability-in-diabetic-and-non-diabetic-patients-with-asymptomatic-coronary-artery-disease-a-cross-sectional-study
#17
Naofumi Yoshida, Hiroyuki Yamamoto, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Daisuke Terashita, Hachidai Takahashi, Kazuhiko Sakaguchi, Yushi Hirota, Takuo Emoto, Hilman Zulkifli Amin, Taiji Mizoguchi, Tomohiro Hayashi, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND: Previously, we have reported that daily glucose fluctuations could affect coronary plaque vulnerability, but the underlying mechanisms remained unclear. This study sought to investigate the impact of CD14(++)CD16(+) monocytes on plaque vulnerability, as assessed by virtual histology intravascular ultrasound (VH-IVUS), as well as their relationship to fluctuating glucose levels in patients with asymptomatic coronary artery disease (CAD). METHODS: Fifty-one patients with asymptomatic CAD, who were undergoing lipid-lowering therapy and underwent VH-IVUS evaluation for angiographically mild to moderate lesions, were enrolled in the study...
August 8, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28743062/peripheral-leucocytes-and-tissue-gene-expression-of-granzyme-b-perforin-system-and-serpinb9-impact-on-inflammation-and-insulin-resistance-in-coronary-atherosclerosis
#18
Eman F Sanad, Nadia M Hamdy, Adel K El-Etriby, Samer A Sebak, Hala O El-Mesallamy
AIM: The imbalance between proapoptotic granzyme B (GZB)/perforin (PRF) system and proteinase inhibitor-9 (PI-9; serpinB9); the only known inhibitor of human GZB, has been demonstrated in atherosclerosis. However, their role in atherosclerosis with the impact of type 2 diabetes mellitus (DM) as well as their contribution to hallmarks of atherosclerosis is not clear. SUBJECTS AND METHODS: ELISA for serum insulin, high sensitivity C-reactive protein (hsCRP) and GZB levels in atherosclerotic coronary artery diseases (CAD) patients were estimated in comparison to apparently healthy controls, while GZB, PRF and PI-9 mRNA expression levels were quantified by Taqman RT-PCR in both peripheral leucocytes and atherosclerotic tissues...
July 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28740629/comparison-of-coronary-artery-disease-guidelines-with-extracted-knowledge-from-data-mining
#19
Peyman Rezaei-Hachesu, Azadeh Oliyaee, Naser Safaie, Reza Ferdousi
Introduction: Coronary artery disease (CAD) is one of the major causes of disability and death in the world. Accordingly utilizing from a national and update guideline in heart-related disease are essential. Finding interesting rules from CAD data and comparison with guidelines was the objectives of this study. Methods: In this study 1993 valid and completed records related to patients (from 2009 to 2014) who had suffered from CAD were recruited and analyzed. Total of 25 variable including a target variable (CAD) and 24 inputs or predictor variables were used for knowledge discovery...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28694612/cerebral-and-coronary-vasculature-in-disease-associations-and-dissociations-in-the-south-indian-population
#20
Krishnan Srinivasan, Srinivasan Ravikumar, Sadanandavalli Retnaswami Chandra, Selva Ganapathy, G S Ravi
INTRODUCTION: Cerebrovascular accidents constitute the most common cause of disability all over the world. In India prevalence rate is 545 per 100000 and mortality rate is around 7.5 per thousand. Therefore the authors undertook a study on patients who underwent coronary artery bypass surgery (CABG). They were investigated for clinical and/or radiological evidence of cerebrovascular disease (CVD) with the aim to decide on early neurological intervention. PATIENTS AND METHODS: 210 patients who had undergone CABG were evaluated with neck vessel Doppler using high resolution duplex scanner system and computed tomography (CT) scan as well as MR angiogram (MRA) in addition to assessment of co morbid risk factors...
July 2017: Journal of Neurosciences in Rural Practice
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