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DM and CAD

Mayur Agrawal, Preksha Dwivedi, V K Sharma, T N Dubey
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Jia Teng Sun, Yan Liu, Lin Lu, Hong Juan Liu, Wei Feng Shen, Ke Yang, Rui Yan Zhang
Although high-density lipoprotein (HDL) can exhibit anti-inflammatory properties, these potent activities can become deficient and even transform into proinflammatory effects under various pathophysiological states. We investigated the effect of diabetic HDL on the inflammatory response in human monocytes and its relation to the existence of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (DM). HDL was isolated from DM patients with (n = 61) or without (n = 31) CAD (diameter stenosis ≥50%) and healthy controls (n = 40)...
August 30, 2016: American Journal of Cardiology
Charlotte H So, Mark H Eckman
The combined use of aspirin and oral anticoagulant therapy in patients with atrial fibrillation (AF) and stable coronary artery disease (CAD) has been questioned due to an increased risk of major bleeding with little to no benefit in preventing ischemic events. (1) To better understand patterns and indications for combined antiplatelet and anticoagulant therapy and identify patients who might reasonably be treated with oral anticoagulant (OAC) therapy alone. (2) To perform an updated literature review regarding the use of combined antiplatelet and OAC therapy in patients with AF and stable CAD...
September 24, 2016: Journal of Thrombosis and Thrombolysis
R Akhtar, H Ahmed, M N Afzal, H R Rehman, I Rashid, S Imran
Objective: Obesity and diabetes mellitus (DM) are interconnected conditions that share a number of pathophysiological mechanisms such as dyslipidaemia leading to cardiovascular complications. The present study was conducted to determine the individual and combined effect of DM and obesity on dyslipidaemia and ultimately on silent coronary artery disease (CAD). Methods: The patients selected from urban and rural areas of Lahore were recruited on the basis of body mass index (BMI) and fasting blood sugar (FBS) and were classified in four groups: (Group A; obese-diabetic, Group B; non-obese and diabetic, Group C; obese and non-diabetic and Group D; non-obese and non-diabetic)...
March 16, 2016: West Indian Medical Journal
Vivekanandhan Aravindhan, Haridoss Madhumitha
Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. The synergistic interaction between these two comorbidities is through sterile inflammation which is now being addressed as metabolic inflammation or metainflammation, which plays a pivotal role during both early and late stages of T2DM and also serves as a link between T2DM and CAD...
2016: Journal of Diabetes Research
Oana Sorop, Mieke van den Heuvel, Nienke S van Ditzhuijzen, Vincent J de Beer, Ilkka Heinonen, Richard W B van Duin, Zhichao Zhou, Sietse J Koopmans, Daphne Merkus, Wim van der Giessen, A H Jan Danser, Dirk Jan Duncker
Coronary microvascular dysfunction (CMD) has been proposed as an important component of diabetes mellitus (DM) and hypercholesterolemia-associated coronary artery disease (CAD). Previously we observed that 2.5 months of DM and high fat diet (HFD) blunted bradykinin (BK)-induced vasodilation and attenuated endothelin-1 (ET-1)- mediated vasoconstriction. Here, we studied the progression of CMD after 15 months in a large animal model of CAD. Ten male pigs received HFD in the absence, (HFD, n=5) or presence of streptozotocin-induced DM (DM+HFD, n=5)...
September 2, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Shingo Kato, Kazuki Fukui, Hidekuni Kirigaya, Daiki Gyotoku, Naoki Iinuma, Yuka Kusakawa, Kohei Iguchi, Tatsuya Nakachi, Tae Iwasawa, Kazuo Kimura
BACKGROUND: The present study determined whether dipeptidyl peptidase-4 (DPP-4) inhibition by alogliptin improves coronary flow reserve (CFR) and left ventricular election fraction (LVEF) in patients with type 2 DM and CAD. MATERIALS AND METHODS: Twenty patients with type 2 DM and known or suspected CAD were randomly allocated to receive diet therapy plus alogliptin (n=10; mean age, 73.3±6.6y) or a control group given diet therapy and glimepiride (n=10; mean age, 76...
November 15, 2016: International Journal of Cardiology
Usman Baber, Michael E Farkouh, Yaron Arbel, Paul Muntner, George Dangas, Michael J Mack, Taye H Hamza, Roxana Mehran, Valentin Fuster
BACKGROUND: The optimal method of coronary revascularization among patients with diabetes mellitus (DM) and multivessel coronary artery disease (CAD) complicated by chronic kidney disease (CKD) remains unknown. PURPOSE: To examine the impact of coronary artery bypass surgery (CABG) vs. percutaneous coronary intervention (PCI) on cardiovascular outcomes in patients with diabetes with and without CKD. METHODS: We conducted an 'as-treated' subgroup analysis of the FREEDOM trial to examine the therapeutic efficacy of CABG vs...
August 29, 2016: European Heart Journal
Philipp Blanke, Christopher Naoum, Amir Ahmadi, Chaitu Cheruvu, Jeanette Soon, Chesnal Arepalli, Heidi Gransar, Stephan Achenbach, Daniel S Berman, Matthew J Budoff, Tracy Q Callister, Mouaz H Al-Mallah, Filippo Cademartiri, Kavitha Chinnaiyan, Ronen Rubinshtein, Hugo Marquez, Augustin DeLago, Todd C Villines, Martin Hadamitzky, Joerg Hausleiter, Leslee J Shaw, Philipp A Kaufmann, Ricardo C Cury, Gudrun Feuchtner, Yong-Jin Kim, Erica Maffei, Gilbert Raff, Gianluca Pontone, Daniele Andreini, Hyuk-Jae Chang, Benjamin W Chow, James Min, Jonathon Leipsic
OBJECTIVES: The goal of this study was to determine the long-term prognostic value of coronary computed tomography angiography (CTA) among patients with diabetes mellitus (DM) compared with nondiabetic subjects. BACKGROUND: The long-term prognostic value of coronary CTA in patients with DM is not well established. METHODS: Patients enrolled in the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry with 5-year follow-up data were identified...
August 20, 2016: JACC. Cardiovascular Imaging
Swaminatha Gurudevan, Pankaj Garg, Shaista Malik, Ramni Khattar, Farhood Saremi, Harvey Hecht, Anthony DeMaria, Jagat Narula
OBJECTIVE: This study was designed to evaluate the severity of subclinical atherosclerosis in patients with asymptomatic impaired fasting glucose (IFG) compared to those with diabetes mellitus (DM) and normal fasting glucose (NFG), as measured by coronary computed tomographic angiography (CCTA). DESIGN: Subjects were divided into three groups: NFG (<100 mg/dL), IFG (100-125 mg/dL) and DM. Coronary artery calcium on non-contrast CT and plaque analysis on CCTA were performed...
2016: BMJ Open
Kadihan Yalçin Şafak, Ayşegül Eratalay, Ebru Dülger İliş, Neslihan Umarusman Tanju
BACKGROUND/AIM: We aimed to detect the incidence of breast arterial calcification (BAC) in patients that underwent mammography and to reveal the relationship of BAC with cardiovascular diseases, cardiovascular risk factors, parity, and breastfeeding. MATERIALS AND METHODS: A total of 1195 female patients were included in this study. Cases that were positive for BAC during mammography were recorded. The relationship of BAC with age, body mass index, parity, breastfeeding, menopause, smoking, alcohol consumption, oral contraceptive use, hormone replacement therapy, and histories of hypertension (HT), diabetes mellitus (DM), coronary artery disease (CAD), and cerebral vascular diseases were investigated...
2016: Turkish Journal of Medical Sciences
Ravi Kiran Munnur, Nitesh Nerlekar, Dennis T L Wong
Coronary artery disease (CAD) is the leading cause of death and disability worldwide. Atherosclerosis, which is the primary pathophysiologic mechanism for the development of plaque leading to CAD, is a multifactorial process resulting from a complex interplay between genetic susceptibility and various risk factors such as hypertension (HT), dyslipidaemia, diabetes mellitus (DM) and smoking. In addition, influences from other disease states such as chronic kidney disease (CKD), obesity and the metabolic syndrome as well as gender and ethnic diversity also contribute to the disease process...
August 2016: Cardiovascular Diagnosis and Therapy
Tetsuji Morishita, Hiroyasu Uzui, Hiroyuki Ikeda, Naoki Amaya, Kenichi Kaseno, Kentaro Ishida, Yoshitomo Fukuoka, Jong-Dae Lee, Hiroshi Tada
OBJECTIVES: Circulating endothelial progenitor cells (EPCs), which have the ability to differentiate into mature endothelial cells, can elicit angiogenesis, vasculogenesis and vessel repair in cardiac ischemia and vascular injuries caused by endothelial damage. Serum 1,5-anhydro-d-glucitol (1,5-AG), which is a useful clinical marker of postprandial hyperglycemia, eicosapentaenoic acid (EPA), and arachidonic acid (AA) are newly identified risk factors for coronary artery disease (CAD)...
October 15, 2016: International Journal of Cardiology
Supriya Bajaj, Vijay Mahajan, Sumit Grover, Amit Mahajan, Nipun Mahajan
INTRODUCTION: Coronary Artery Disease (CAD) among women presents atypically with atypical chest pain, neck pain, nausea, fatigue and dyspnoea. Co-existing co-morbidities such as Diabetes Mellitus (DM) and hypertension along with difference in risk factor prevalence makes it necessary to have a gender specific approach. AIM: To study gender specific differences in diagnosing and treating Acute Myocardial Infarction (AMI) in North Indian population. MATERIALS AND METHODS: Fifty consecutive men and women presenting with AMI were studied...
May 2016: Journal of Clinical and Diagnostic Research: JCDR
C A Jayashankar, Henley Punnen Andrews, Vijayasarathi, Venkata BharatKumar Pinnelli, Basappaji Shashidharan, H N Nithin Kumar, Swaapnika Vemulapalli
AIM: We aimed to identify the predictors of coronary artery disease (CAD) in patients with type 2 diabetes mellitus (type 2 DM). METHODS: About fifty Asian Indian patients with type 2 DM patients aged >40 years and fifty sex- and age-matched nondiabetic controls were enrolled for this study. Following complete medical history and baseline clinical data, laboratory investigations were performed to assess fasting and postprandial plasma glucose levels, lipid profile, blood urea, serum creatinine, and serum uric acid levels...
July 2016: Journal of Natural Science, Biology, and Medicine
Mohamed Loutfi, Mohamed A Sadaka, Mohamed Sobhy
UNLABELLED: Diabetes mellitus (DM) increases the risk of adverse outcomes after coronary revascularization. Controversy persists regarding the optimal revascularization strategy for diabetic patients with multivessel coronary artery disease (MVD). AIM: The aim of this study was to assess the outcomes of drug-eluting stent (DES) insertion in DM and non-DM patients with complex coronary artery disease (CAD) after risk stratification by the percutaneous coronary intervention with taxus and cardiac surgery (SYNTAX) score...
2016: Clinical Medicine Insights. Cardiology
Tünay Kandemir, Selda Muslu, Dilek Kalaycı, Erbin Kandemir
OBJECTIVE: The aim of the present study was to retrospectively evaluate the association between accompanying systemic disorders and major complications developing in the early postoperative period in patients who underwent simultaneous bilateral total knee arthroplasty with combined spinal and epidural anaesthesia. METHODS: In the present study, the medical records of a total of 456 patients were analyzed. Preoperative data, including the American Society of Anesthesiologists physical status and presence of coronary artery disease (CAD), chronic pulmonary disease, diabetes mellitus (DM), hypertension and renal insufficiency were recorded...
June 2015: Turkish Journal of Anaesthesiology and Reanimation
Adam J Buntaine, Binita Shah, Jeffrey D Lorin, Steven P Sedlis
Patients with diabetes mellitus (DM) have more severe CAD and higher mortality in acute coronary syndrome (ACS) than patients without DM. The optimal mode of revascularization-coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI)-remains controversial in this setting. For patients with DM and ST-segment elevation myocardial infarction, prompt revascularization of the culprit artery via PCI is generally preferable. In non-ST-elevation ACS, the decision on mode of revascularization is more challenging...
August 2016: Current Cardiology Reports
Benoit J Arsenault, Payal Kohli, Gilles Lambert, David A DeMicco, Rachel Laskey, Michael M Messig, John J P Kastelein, David D Waters
Whether biomarkers associated with cardiovascular disease risk also predict incident diabetes mellitus (DM) is unknown. Our objective was to determine if a panel of 18 biomarkers previously associated with risk of cardiovascular disease also predicts incident DM in statin-treated patients with coronary artery disease (CAD). The Treating to New Targets (TNT) study is a randomized trial that compared the efficacy of high (80 mg) versus low (10 mg) dose atorvastatin for the secondary prevention of coronary heart disease events...
August 15, 2016: American Journal of Cardiology
Akihiro Kurita, Hidehiko Itoh, Fumi Sato, Yasuhiro Ichibori, Akira Yoshida
PURPOSE: Although alterations in longitudinal systolic function have been considered the earliest sign of cardiac damage, the importance of longitudinal fractional shortening (LFS), which reflects left ventricular longitudinal contraction, has not been studied in detail. We introduce a new method of measuring LFS by echocardiography and evaluate its efficiency. METHODS: Our study population consisted of 120 patients with diabetes mellitus (DM), 29 healthy volunteers, and 12 patients with coronary artery disease (CAD)...
September 2008: Journal of Medical Ultrasonics
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