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https://www.readbyqxmd.com/read/29751567/the-gender-impact-on-morphogenetic-variability-in-coronary-artery-disease-a-preliminary-study
#1
Radmila Karan, Biljana Obrenovic-Kircanski, Suzana Cvjeticanin, Natasa Kovacevic-Kostic, Milos Velinovic, Vladimir Milicevic, Milica Vranes-Stoimirov, Dejan Nikolic
We analyzed morphogenetic variability and degree of genetic homozygosity in male and female individuals with coronary artery disease (CAD) versus unaffected controls. We have tested 235 CAD patients; 109 were diagnosed also with diabetes mellitus (DM) and 126 with hypertension (HTN). We additionally evaluated 152 healthy individuals without manifested CAD. For the evaluation of the degree of recessive homozygosity, we have performed the homozygously recessive characteristics (HRC) test and tested 19 HRCs. In controls, the frequency of HRC for males was 2...
May 3, 2018: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/29742684/myocardial-injury-after-noncardiac-surgery-incidence-and-predictors-from-a-prospective-observational-cohort-study-at-an-indian-tertiary-care-centre
#2
Rubin George, Vidya P Menon, Fabia Edathadathil, Sabarish Balachandran, Merlin Moni, Dipu Sathyapalan, Preetha Prasanna, Gokuldas S, Jerry Paul, Chandrababu K K, Lakshmi Kumar, Ashok Pillai
Asymptomatic myocardial injury following noncardiac surgery (MINS) is an independent predictor of 30-day mortality and may go unrecognized based on standard diagnostic definition for myocardial infarction (MI). Given lack of published research on MINS in India, our study aims to determine incidence of MINS in patients undergoing noncardiac surgery at our tertiary care hospital, and evaluate the clinical characteristics including 30-day outcome.The prospective observational study included patients >65 years or >45 years with either hypertension (HTN), diabetes mellitus (DM), coronary artery disease (CAD), cerebrovascular accident (CVA), or peripheral arterial disease undergoing noncardiac surgery...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29725563/clinicoradiological-correlation-of-infarct-patterns-on-diffusion-weighted-magnetic-resonance-imaging-in-stroke
#3
Zainab Hussain, Kiran Hilal, Muhammad Ahmad, Zafar Sajjad, Raza Sayani
Diffusion-weighted magnetic resonance imaging (DW-MRI) represents a major advance in the early diagnosis of acute ischemic stroke. It can detect edema due to ischemia in the brain tissue. It not only establishes the presence and location of ischemic brain injury but also a relatively new concept is the determination of infarct patterns seen on diffusion imaging and its clinical correlation. Objective To determine the frequency of various infarct patterns and their relationship with functional outcome of the patient...
March 2, 2018: Curēus
https://www.readbyqxmd.com/read/29723218/associations-between-retinal-arteriolar-and-venular-calibre-with-the-prevalence-of-impaired-fasting-glucose-and-diabetes-mellitus-a-cross-sectional-study
#4
Kevin Phan, Paul Mitchell, Gerald Liew, Adam J Plant, Sarah B Wang, Aravinda Thiagalingam, George Burlutsky, Bamini Gopinath
BACKGROUND: This study aims to explore retinal vessel calibre in individuals at risk of coronary artery disease (CAD), diagnosed with impaired fasting glucose (IFG) or diabetes mellitus (DM), and whether indices of CAD extent and severity modifies these associations with DM. METHODS: A cross-sectional study was undertaken of 1680 patients presenting to Westmead Hospital (Sydney, Australia) for evaluation of potential CAD. Baseline digital retinal photographs, cardiovascular risk factor measurements, fasting blood tests and self-reported diabetes by patient questionnaire was recorded...
2018: PloS One
https://www.readbyqxmd.com/read/29716394/novel-biomarkers-for-coronary-restenosis-occurrence-after-drug-eluting-stent-implantation-in-patients-with-diabetes-having-stable-coronary-artery-disease
#5
Zufar Gabbasov, Sergey Kozlov, Ivan Melnikov, Svetlana Byazrova, Olga Saburova, Lyudmila Prokofieva, Martin Caprnda, Eduard Curilla, Ludovit Gaspar, Luis Rodrigo, Peter Kruzliak, Vladimir Smirnov
The purpose of the study was to assess whether the occurrence of restenosis is associated with CD45+ platelet count and neutrophil to lymphocyte ratio in patients with type 2 diabetes mellitus (DM) after drug-eluting stent (DES) implantation for stable coronary artery disease (CAD). The study comprised 126 patients, including 55 patients with type 2 DM and stable CAD who underwent elective coronary artery stenting with DES and follow-up angiography within 6 to 12 months. Blood samples were collected from each patient on the morning of the coronary angiography procedure...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/29707915/development-of-an-organ-specific-insert-phantom-generated-using-a-3d-printer-for-investigations-of-cardiac-computed-tomography-protocols
#6
Kamarul A Abdullah, Mark F McEntee, Warren Reed, Peter L Kench
INTRODUCTION: An ideal organ-specific insert phantom should be able to simulate the anatomical features with appropriate appearances in the resultant computed tomography (CT) images. This study investigated a 3D printing technology to develop a novel and cost-effective cardiac insert phantom derived from volumetric CT image datasets of anthropomorphic chest phantom. METHODS: Cardiac insert volumes were segmented from CT image datasets, derived from an anthropomorphic chest phantom of Lungman N-01 (Kyoto Kagaku, Japan)...
April 30, 2018: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/29691285/relationships-between-chronic-comorbidities-and-the-atherosclerosis-indicators-ankle-brachial-index-and-brachial-ankle-pulse-wave-velocity-in-patients-with-type-2-diabetes-mellitus
#7
Chun-Chuan Lee, Ming-Chieh Tsai, Sung-Chen Liu, Chi-Feng Pan
This study aimed to determine associations between ankle-brachial index (ABI) and brachial-ankle pulse wave velocity (baPWV) with different comorbidities in patients with type 2 diabetes mellitus (DM). Records of patients with type 2 DM who received an ABI and baPWV examination between August 2013 and February 2015 were retrospectively reviewed. Associations of ABI and baPWV with chronic kidney disease (CKD), chronic liver disease (CLD), coronary artery disease (CAD) and diabetic nephropathy (DN) were examined by regression analysis...
April 24, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29688734/assessing-the-relation-of-epicardial-fat-thickness-and-volume-quantified-by-256-slice-computed-tomography-scan-with-coronary-artery-disease-and-cardiovascular-risk-factors
#8
Maryam Mohammadzadeh, Vahid Mohammadzadeh, Madjid Shakiba, Marzieh Motevalli, Azadeh Abedini, Sakineh Kadivar, Pouya Entezari, Ali Mohammadzadeh
BACKGROUND: This study aimed to investigate the association between epicardial adipose tissue (EAT) and coronary artery disease (CAD) as well as cardiovascular risk factors. METHODS: Complete medical records of subjects were reviewed and cardiovascular risk factors were recorded. Epicardial fat volume (EFV) and epicardial fat thickness (EFT) were measured using digital volumetry of acquired images using a 256-slice CT-scanner. Calcium score was measured using Agatston method in non-contrast images...
March 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29685675/predictive-value-of-coronary-computed-tomography-angiography-in-asymptomatic-individuals-with-diabetes-mellitus-systematic-review-and-meta-analysis
#9
Ebba Beller, Felix G Meinel, Franziska Schoeppe, Wolfgang G Kunz, Kolja M Thierfelder, Jörg Hausleiter, Fabian Bamberg, U Joseph Schoepf, Verena S Hoffmann
BACKGROUND: Coronary CT angiography (CTA) is generally not established as a screening tool for asymptomatic individuals. However, it is controversial whether this test may have a role for screening asymptomatic individuals with diabetes mellitus (DM) due to the high prevalence of asymptomatic coronary artery disease (CAD) in this subgroup. METHODS: We searched PubMed and EMBASE through May 2017 for studies that reported on the association between findings at coronary CTA and future cardiac events in asymptomatic individuals with DM...
April 12, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29662507/new-predictors-of-in-stent-restenosis-in-patients-with-diabetes-mellitus-undergoing-percutaneous-coronary-intervention-with-drug-eluting-stent
#10
Jian-Long Wang, Zheng Qin, Zhi-Jian Wang, Dong-Mei Shi, Yu-Yang Liu, Ying-Xin Zhao, Li-Xia Yang, Wan-Jun Cheng, Yu-Jie Zhou
Background: Percutaneous coronary intervention (PCI) had become the major therapeutic procedure for coronary artery disease (CAD), but the high rate of in-stent restenosis (ISR) still remained an unsolved clinical problem in clinical practice. Increasing evidences suggested that diabetes mellitus (DM) was a major risk factor for ISR, but the risk predictors of ISR in CAD patients with DM had not been well characterized. The aim of this study was to investigate the clinical and angiographic characteristic predictors significantly associated with the occurrence of ISR in diabetic patients following coronary stenting with drug-eluting stent (DES)...
February 2018: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/29605471/thermal-heterogeneity-of-carotid-arteries-as-a-novel-biomarker-in-patients-with-diabetes-mellitus-assessed-for-coronary-artery-disease
#11
G Tzanis, M Bonou, G Benetos, S Biliou, S Liatis, C Kapelios, K Toutouzas, D Tousoulis, J Barbetseas
BACKGROUND: Vulnerable plaque plays crucial role in prognosis of diabetes mellitus (DM). Microwave radiometry (MWR) allows measurement of the temperature of tissues, thus indirectly reflecting inflammation, a characteristic of atherosclerotic plaque stability. Aim of the study was to evaluate the relation of carotid artery inflammation with glycemic control and presence of coronary artery disease (CAD). METHODS: We included 112 patients (65 ± 9 years, 30 ± 5 kg/m2 , 74 DM and 38 non-DM, with a 2:1 ratio) that were referred for scheduled coronary angiography (CA) for evaluation of their clinical condition...
March 29, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29578439/occupational-hazards-as-a-risk-factor-of-onset-and-unfavorable-outcome-of-ischemic-heart-disease
#12
H Svitlyk, M Harbar, V Salo, O Kapustynskyy, Y Svitlyk
Objective -to identify the role of occupational hazards (OH) as a risk factor of onset and unfavorable outcome of coronary artery disease (CAD). Retrospective study included analysis of 307 case reports of CAD patients, including 59 patients with long term history of OH exposure. Prospective study included observation of 244 STEMI patients during their in-patient treatment, including 113 patients with prior exposure to OH. OH were demonstrated to contribute to the risk of CAD, and to be directly involved in atherosclerotic coronary artery (CA) injury, its role being equal to that of the classical risk factors, such as arterial hypertension (AH), dyslipidemia, and diabetes mellitus (DM)...
February 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29572680/syntax-score-and-outcomes-of-coronary-revascularization-in-diabetic-patients
#13
REVIEW
Amartya Kundu, Partha Sardar, Kevin O'Day, Saurav Chatterjee, Theophilus Owan, J Dawn Abbott
PURPOSE OF REVIEW: This review describes the dynamic relationship between diabetes mellitus (DM) and coronary artery disease (CAD) with respect to different revascularization strategies and how angiographic tools such as the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score can supplement clinical decision-making. RECENT FINDINGS: The SYNTAX score characterizes the anatomical extent of CAD in terms of the number of lesions, functional importance, and complexity...
March 23, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29566676/correction-to-hba-1c-versus-oral-glucose-tolerance-test-as-a-method-to-diagnose-diabetes-mellitus-in-vascular-surgery-patients
#14
Iren D Hjellestad, Marianne C Astor, Roy M Nilsen, Eirik Søfteland, Torbjørn Jonung
The authors found errors in Table 1 after publication of the original article [1].The correct values for medical history of coronary artery disease (CAD) at baseline are 110 (40%) of all patients, 54 (35.5%) of patients categorized as having normoglycaemia, 42 (46.7%) of patients categorized as having intermediate hyperglycaemia, and 14 (42.4%) of patients categorized as having DM.All presented numbers and calculations in Table 1 are checked. No other errors were found. The presented errors did not affect results, scientific content or conclusions...
March 22, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29541610/echocardiographic-feature-of-diabetic-cardiomyopathy-where-are-we-now
#15
REVIEW
Kazuaki Negishi
We are now entering the very exciting era of treatment and management of diabetes mellitus (DM) with the emergence of new therapeutic agents, including sodium-glucose cotransporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase-4 inhibitor (DPP-4i). From a cardiology and echocardiography perspective, the existence of diabetic cardiomyopathy has been proven through over four decades of discussion. DM is highly prevalent in patients with heart failure (HF). Independent associations are found after adjusting for hypertension (HTN) and coronary artery disease (CAD)...
February 2018: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/29511691/coronary-atherosclerosis-assessment-by-coronary-ct-angiography-in-asymptomatic-diabetic-population-a-critical-systematic-review-of-the-literature-and-future-perspectives
#16
REVIEW
Andrea Igoren Guaricci, Delia De Santis, Mariangela Carbone, Giuseppe Muscogiuri, Marco Guglielmo, Andrea Baggiano, Gaetano Serviddio, Gianluca Pontone
The prognostic impact of diabetes mellitus (DM) on cardiovascular outcomes is well known. As a consequence of previous studies showing the high incidence of coronary artery disease (CAD) in diabetic patients and the relatively poor outcome compared to nondiabetic populations, DM is considered as CAD equivalent which means that diabetic patients are labeled as asymptomatic individuals at high cardiovascular risk. Lessons learned from the analysis of prognostic studies over the past decade have challenged this dogma and now support the idea that diabetic population is not uniformly distributed in the highest risk box...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29499924/usefulness-of-carotid-plaques-as-predictors-of-obstructive-coronary-artery-disease-and-cardiovascular-events-in-asymptomatic-individuals-with-diabetes-mellitus
#17
Anand Jeevarethinam, Shreenidhi Venuraju, Alain Dumo, Sherezade Ruano, Miranda Rosenthal, Devaki Nair, Mark Cohen, Daniel Darko, Avijit Lahiri, Roby Rakhit
Carotid intima-media thickness (CIMT) measurement and carotid plaque detection by B-mode ultrasound are frequently used as surrogates to predict coronary artery disease (CAD). However, their systematic use in routine clinical management of asymptomatic patients with diabetes mellitus (DM) has not been studied. The aim of the study was to identify carotid parameters that predict cardiovascular events in patients with asymptomatic type 2 DM by evaluating the relation between carotid disease and CAD. This multicenter, observational, prospective study included 259 asymptomatic patients with type 2 DM followed-up for 34 months after measurement of CIMT and carotid plaque with carotid ultrasound, and CAD assessment with computed tomography coronary angiography...
April 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29471931/coronary-artery-bypass-surgery-improves-outcomes-in-patients-with-diabetes-and-left-ventricular-dysfunction
#18
Jeevan Nagendran, Sabin J Bozso, Colleen M Norris, Finlay A McAlister, Jehangir J Appoo, Michael C Moon, Darren H Freed, Jayan Nagendran
BACKGROUND: The role of percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG) in patients with diabetes mellitus (DM) and multivessel coronary artery disease (CAD) has been established by large trials; however, these trials largely excluded patients with left ventricular dysfunction (LVD). OBJECTIVES: The aim of this study was to determine whether treatment with PCI or CABG leads to improved outcomes in patients with DM, CAD, and LVD...
February 27, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29455787/cardiovascular-risk-factors-profile-in-patients-with-acute-coronary-syndrome-with-particular-reference-to-left-ventricular-ejection-fraction
#19
Sheeren Khaled, Rajaa Matahen
BACKGROUND: Acute coronary syndrome (ACS) remains a leading cause of death in the United States. Numerous studies have shown that the degree of LV systolic dysfunction is a major if not the most important determinant of long-term outcome in ACS. OBJECTIVES: To identify the most important risk factors and other clinical predictors which might have impact on left ventricular ejection fraction in patients with ACS. RESULTS: The total patients (299) admitted to our center from July, 2015 till December, 2015; with established diagnosis of ACS were classified in to two groups: Group I: 193 patients with impaired LVEF <40% (64...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29407600/impact-of-cd14-cd16-monocytes-on-coronary-plaque-vulnerability-assessed-by-optical-coherence-tomography-in-coronary-artery-disease-patients
#20
Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND AND AIMS: This study examined the impact of CD14++ CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++ CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT...
February 2018: Atherosclerosis
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