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https://www.readbyqxmd.com/read/28542578/illness-experiences-of-diabetes-in-the-context-of-malaria-in-settings-experiencing-double-burden-of-disease-in-southeastern-tanzania
#1
Emmy Metta, Ajay Bailey, Flora Kessy, Eveline Geubbels, Hinke Haisma
BACKGROUND: Tanzania is doubly burdened with both non-communicable and infectious diseases, but information on how Tanzanians experience the co-existence of these conditions is limited. Using Kleinman's eight prompting questions the study synthesizes explanatory models from patients to describe common illness experiences of diabetes in a rural setting where malaria is the predominant health threat. METHODS: We conducted 17 focus group discussions with adult members of the general community, diabetes patients, neighbours and relatives of diabetes patients to gain insight into shared experiences...
2017: PloS One
https://www.readbyqxmd.com/read/28539143/incidence-of-g-induced-loss-of-consciousness-and-almost-loss-of-consciousness-in-the-royal-air-force
#2
Ellen Slungaard, Judith McLeod, Nicholas D C Green, Amit Kiran, Di J Newham, Stephen D R Harridge
INTRODUCTION: Exposure to sustained +Gz acceleration with inadequate G protection can result in G-induced loss of consciousness (G-LOC) or almost loss of consciousness (A-LOC). The UK Royal Air Force (RAF) last conducted a survey of G-LOC within their military aircrew in 2005 with interventions subsequently introduced. The aim of this study was to repeat the 2005 survey in order to evaluate the impact of those interventions. METHODS: An anonymous questionnaire requesting details of G-LOC and A-LOC events was mailed to all RAF pilots (N = 1878) and weapons systems operators (WSOs) (N = 473), irrespective of aircraft currently flown...
June 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28534702/factors-affecting-recovery-from-anaesthesia-with-propofol-remifentanil-target-controlled-infusion-in-laparoscopic-surgery
#3
Shao-Hua Liu, Ming Tian
Objective This study was performed to analyse factors influencing the effect-site concentration (Ce) of propofol at return of consciousness (ROC) with target-controlled infusion of propofol-remifentanil after laparoscopic surgery. Methods In total, 112 patients who underwent laparoscopic surgery under general anaesthesia were given propofol at the target concentration of 3.5 µg/ml. Remifentanil (Ce: 4.0 ng/ml) and 0.9 mg/kg of rocuronium were administered when the Observer's Assessment of Alertness/Sedation score reached 1...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28532354/the-road-to-certainty-and-back
#4
Gerald Westheimer
The author relates his intellectual journey from eye-testing clinician to experimental vision scientist. Starting with the quest for underpinning in physics and physiology of vague clinical propositions and of psychology's acceptance of thresholds as "fuzzy-edged," and a long career pursuing a reductionist agenda in empirical vision science, his journey led to the realization that the full understanding of human vision cannot proceed without factoring in an observer's awareness, with its attendant uncertainty and open-endedness...
October 14, 2016: Annual Review of Vision Science
https://www.readbyqxmd.com/read/28529306/normalization-of-diffuse-st-depression-with-avr-elevation-after-rehydration-in-a-patient-with-severe-aortic-stenosis
#5
Sachin R Patel, Vikas J Patel, Brittany Clark, George Rust
BACKGROUND Isolated ST elevation in lead aVR in combination with global ST depression with normalization after rehydration is a unique electrocardiographic pattern that is associated with a broad range of diagnoses. Its association with left main coronary artery disease and other acute coronary syndromes suggest the need for early and aggressive cardiac evaluation. CASE REPORT A 53-year-old man presented with altered mental status and loss of consciousness. He was unresponsive, hypotensive, tachycardiac, and diaphoretic...
May 22, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28528727/sexual-inactivity-in-partnered-female-cancer-survivors
#6
Jennifer L Marino, Christobel M Saunders, Martha Hickey
OBJECTIVE: To measure sexual activity in a clinic population of partnered female cancer survivors, and to better understand reasons for sexual inactivity in this population. MATERIALS AND METHODS: Partnered peri- or post-menopausal cancer survivors seen at a specialty clinic for menopause symptoms after cancer completed Fallowfield's Sexual Activity Questionnaire, quality of life measures (the Functional Assessment of Cancer Therapy General, Breast Cancer, and Endocrine Symptom Scales), and the Greene Climacteric Scale...
May 9, 2017: Maturitas
https://www.readbyqxmd.com/read/28525544/bistability-causality-and-complexity-in-cortical-networks-an-in-vitro-perturbational-study
#7
Mattia D'Andola, Beatriz Rebollo, Adenauer G Casali, Julia F Weinert, Andrea Pigorini, Rosa Villa, Marcello Massimini, Maria V Sanchez-Vives
Measuring the spatiotemporal complexity of cortical responses to direct perturbations provides a reliable index of the brain's capacity for consciousness in humans under both physiological and pathological conditions. Upon loss of consciousness, the complex pattern of causal interactions observed during wakefulness collapses into a stereotypical slow wave, suggesting that cortical bistability may play a role. Bistability is mainly expressed in the form of slow oscillations, a default pattern of activity that emerges from cortical networks in conditions of functional or anatomical disconnection...
May 19, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28520577/the-effects-of-remifentanil-on-hemodynamic-response-attenuation-after-electroconvulsive-therapy-under-sevoflurane-anesthesia
#8
Feray Erdil, Ulku Ozgul, Mukadder Şanli, Gülay Kayhan, Cemil Çolak, Mahmut Durmuş
PURPOSE: We evaluated the effects of a single loading dose of remifentanil (1 μg/kg) administered as an adjunct to sevoflurane, on the duration of seizure activity, recovery times, and hemodynamic profiles, during electroconvulsive therapy. METHODS: The patients were randomly allocated to receive sevoflurane-saline (Group SS) or sevoflurane-remifentanil (Group SR). Sevoflurane (8%) was initiated for anesthesia induction in both groups until loss of consciousness was achieved...
May 18, 2017: Journal of ECT
https://www.readbyqxmd.com/read/28508963/hemodiafiltration-for-hepatic-encephalopathy-induced-by-budd-chiari-syndrome-in-a-patient-with-end-stage-kidney-disease
#9
Takuya Wakamatsu, Suguru Yamamoto, Kenya Kamimura, Takeshi Nakatsue, Noriaki Iino, Seitaro Iguchi, Yoshikatsu Kaneko, Shin Goto, Junichiro James Kazama, Ichiei Narita
A 36-year-old woman who was undergoing dialysis for end-stage kidney disease (ESKD) was admitted to our hospital with consciousness disorder. She was diagnosed with Budd-Chiari syndrome due to antiphospholipid syndrome at the age of 28 years. Her kidney function and leg edema gradually deteriorated. After initiation of hemodialysis (HD), transient loss of consciousness due to hepatic encephalopathy during HD treatment occurred frequently. Her kidney replacement therapy was changed to online hemodiafiltration (HDF), which dramatically improved her hepatic coma...
November 2016: CEN Case Reports
https://www.readbyqxmd.com/read/28506441/association-of-traumatic-brain-injury-and-alzheimer-disease-onset-a-systematic-review
#10
REVIEW
J Julien, S Joubert, M-C Ferland, L C Frenette, M M Boudreau-Duhaime, L Malo-Véronneau, E de Guise
BACKGROUND: Inconsistencies regarding the risk of developing Alzheimer disease after traumatic brain injury (TBI) remain in the literature. Indeed, why AD develops in certain TBI patients while others are unaffected is still unclear. OBJECTIVE: The aim of this study was to performed a systematic review to investigate whether certain variables related to TBI, such as TBI severity, loss of consciousness (LOC) and post-traumatic amnesia (PTA), are predictors of risk of AD in adults...
May 11, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28501796/nitric-oxide-synthase-inhibition-restores-orthostatic-tolerance-in-young-vasovagal-syncope-patients
#11
Julian M Stewart, Richard Sutton, Mira L Kothari, Amanda M Goetz, Paul Visintainer, Marvin Scott Medow
OBJECTIVE: Syncope is sudden transient loss of consciousness and postural tone with spontaneous recovery; the most common form is vasovagal syncope(VVS). We previously demonstrated impaired post-synaptic adrenergic responsiveness in young VVS patientswas reversed by blocking nitric oxide synthase(NOS). We hypothesised that nitric oxide may account for reduced orthostatic tolerance in young recurrent VVS patients. METHODS: We recorded haemodynamics in supine VVS and healthy volunteers (aged 15-27 years), challenged with graded lower body negative pressure (LBNP) (-15, -30, -45 mm Hg each for 5 min, then -60 mm Hg for a maximum of 50 min) with and without NOS inhibitor N(G)-monomethyl-L-arginine acetate(L-NMMA)...
May 13, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28490528/combining-new-tools-to-assess-renal-function-and-morphology-a-holistic-approach-to-study-the-effects-of-aging-and-a-congenital-nephron-deficit
#12
Stefania Geraci, Jorge Chacón-Caldera, Luise Anne Cullen-McEwen, Lothar R Schad, Carsten Sticht, Victor G Puelles, John F Bertram, Norbert Gretz
Recently, new methods for assessing renal function in conscious mice (transcutaneous assessment) and for counting and sizing all glomeruli in whole kidneys (MRI) were described. In the present study, these methods were used to assess renal structure and function in aging mice, and in mice born with a congenital low nephron endowment. Age-related nephron loss was analysed in adult C57BL/6 mice (10-50 weeks of age) and congenital nephron deficit was assessed in glial cell line-derived neurotrophic factor heterozygous (GDNF HET) null mutant mice...
May 10, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28490286/loss-of-consciousness-collapse-and-associated-driving-restrictions-a-retrospective-case-note-review-an-important-reminder-regarding-driving-restrictions
#13
Adam Williamson, Scott Muir
Background and aims National guidelines outlining medical standards for fitness to drive are provided by The Driver and Vehicle Licensing Agency. We aimed to establish whether patients presenting with collapse or loss of consciousness received documented advice regarding driving restrictions, if appropriate for their working diagnosis. Methods and results A retrospective case note review was undertaken over a four-month period for emergency patients clinically coded as seizure/convulsion (R568) and collapse/syncope (R55X); 163 patients had a primary or working diagnosis on discharge that suggested driving status and restrictions could have been reviewed...
January 1, 2017: Scottish Medical Journal
https://www.readbyqxmd.com/read/28484353/tachycardia-as-a-negative-prognostic-factor-for-stroke-outcome
#14
Amina Nakicevic, Salem Alajbegovic, Lejla Alajbegovic
INTRODUCTION: The outcome of stroke, especially lethal one is significant, as in the hemorrhagic as well as in ischemic stroke. GOAL: was to show the impact on the stroke outcome of tachycardia correlated with lesion localization. MATERIAL AND METHODS: Material for our work was patients who were treated due to the stroke at the Neurology Clinic Sarajevo in the period from 31 March 2015 until 01 January 2016. A total of 544 stoke patients were treated in the reporting period, 221 (44...
March 2017: Materia Socio-medica
https://www.readbyqxmd.com/read/28479984/convergent-minds-some-questions-about-mental-evolution
#15
Matt Cartmill
In investigating convergent minds, we need to be sure that the things we are looking at are both minds and convergent. In determining whether a shared character state represents a convergence between two organisms, we must know the wider distribution and primitive state of that character so that we can map that character and its state transitions onto a phylogenetic tree. When we do this, some apparently primitive shared traits may prove to represent convergent losses of cognitive capacities. To avoid having to talk about the minds of plants and paramecia, we need to go beyond assessments of behaviourally defined cognition to ask questions about mind in the primary sense of the word, defined by the presence of mental events and consciousness...
June 6, 2017: Interface Focus
https://www.readbyqxmd.com/read/28476432/fainting-episode-in-a-pacemaker-dependent-patient-with-two-implanted-devices-too-much-of-a-good-thing
#16
Filippo Maria Cauti, Pietro Rossi, Luigi Iaia, Stefano Bianchi
A 73 year old man with CRT-D system and pacemaker dependence was admitted to the emergency department due to a syncopal episode. The device interrogation was performed. An RV ventricular sensing test was executed in VVI mode at 50 b/m. During testing the patient developed transient loss of consciousness with full recovery after stopping the sensing test. Applying asynchronous pacing mode, a pacing spike occurred at a faster rate of 65 b/m without evoking any ventricular capture. Looking at the chest X-ray, we found an abandoned right sided, single chamber VVI pacemaker in a submuscular pocket...
April 22, 2017: Journal of Electrocardiology
https://www.readbyqxmd.com/read/28471243/utility-of-providing-a-concussion-definition-in-the-assessment-of-concussion-history-in-former-nfl-players
#17
Michael L Alosco, Johnny Jarnagin, Yorghos Tripodis, Brett Martin, Christine Chaisson, Christine M Baugh, Alcy Torres, Christopher J Nowinski, Robert C Cantu, Robert A Stern
OBJECTIVE: Former National Football League (NFL) players' working knowledge of concussion has not yet been evaluated, despite this population being a major clinical research target due to the association between repetitive head impacts (RHI) and long-term clinical impairments. This study examined former NFL players' understanding of the current concussion definition, and the association between number of concussions with clinical function. METHODS: 95 former NFL players (mean age = 55...
May 4, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28470006/efficacy-of-intragastric-balloon-on-weight-reduction-saudi-perspective
#18
Ebtissam Saleh Almeghaiseeb, Muhammad Farooq Ashraf, Reem Abdullah Alamro, Abdulaziz Omar Almasoud, Abdulrahman Ali Alrobayan
AIM: To evaluate the safety and efficacy of intragastric balloon (IGB) in weight reduction in obese patients referred to a tertiary hospital in the Kingdom of Saudi Arabia. METHODS: Three hundred and one consecutive obese individuals, who underwent IGB placement during January 2009 to May 2015, were analyzed. The subjects aged 18 to 60 years and had a minimum body mass index (BMI) of 27 kg/m(2). The IGB was placed under conscious sedation and kept for 6 mo. Anthropometric measurements were recorded during and after 6 mo of IGB removal...
April 16, 2017: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/28469501/an-autopsy-case-of-sudden-unexpected-death-of-a-young-adult-in-a-hot-bath-molecular-analysis-using-next-generation-dna-sequencing
#19
Yukiko Hata, Koshi Kinoshita, Naoki Nishida
We report a case of sudden unexpected death of a young woman who was found in a bathtub of hot water. The autopsy concluded that all possible causes of sudden loss of consciousness, except cardiac origin, could be excluded. However, the heart did not show any obvious pathological changes. We used next-generation DNA sequencing (NGS) to examine 73 genes and detected 3 rare, potentially pathogenic variants with minor allele frequencies ⩽1.0%. The pathogenicity of these variants was evaluated using 8 in silico predictive algorithms, and SCN5A_p...
2017: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/28465843/hypercapnea-and-acidemia-despite-hyperventilation-following-endotracheal-intubation-in-a-case-of-unknown-severe-salicylate-poisoning
#20
Shannon M Fernando, Valérie Charbonneau, Hans Rosenberg
Salicylates are common substances for deliberate self-harm. Acute salicylate toxicity is classically associated with an initial respiratory alkalosis, followed by an anion gap metabolic acidosis. The respiratory alkalosis is achieved through hyperventilation, driven by direct stimulation on the respiratory centers in the medulla and considered as a compensatory mechanism to avoid acidemia. However, in later stages of severe salicylate toxicity, patients become increasingly obtunded, with subsequent loss of airway reflexes, and therefore intubation may be necessary...
2017: Case Reports in Critical Care
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