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https://www.readbyqxmd.com/read/28430108/a-network-physiology-approach-to-the-assessment-of-the-link-between-sinoatrial-and-ventricular-cardiac-controls
#1
Alberto Porta, Vlasta Bari, Beatrice De Maria, Mathias Baumert
A network physiology approach to evaluate the strength of the directed interactions among cardiac controls at sinoatrial and ventricular levels and respiration (R) is proposed. The network is composed of three nodes (i.e. sinoatrial and ventricular cardiac controls and R) and their activity is exemplified by the variability of heart period (HP), the variability of the duration of the electrical activity of the heart approximated as the temporal distance between Q-wave onset and T-wave end or apex (i.e. QTe or QTa) and thoracic movements respectively...
April 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28429787/heat-temperature-and-clausius-inequality-in-a-model-for-active-brownian-particles
#2
Umberto Marini Bettolo Marconi, Andrea Puglisi, Claudio Maggi
Methods of stochastic thermodynamics and hydrodynamics are applied to a recently introduced model of active particles. The model consists of an overdamped particle subject to Gaussian coloured noise. Inspired by stochastic thermodynamics, we derive from the system's Fokker-Planck equation the average exchanges of heat and work with the active bath and the associated entropy production. We show that a Clausius inequality holds, with the local (non-uniform) temperature of the active bath replacing the uniform temperature usually encountered in equilibrium systems...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429371/design-of-a-short-non-uniform-acquisition-protocol-for-quantitative-analysis-in-dynamic-cardiac-spect-imaging-a-retrospective-123-i-mibg-animal-study
#3
Yunlong Zan, Yong Long, Kewei Chen, Biao Li, Qiu Huang, Grant T Gullberg
PURPOSE: Our previous works have found that quantitative analysis of (123) I-MIBG kinetics in the heart with dynamic single-photon emission computed tomography (SPECT) offers the potential to quantify the innervation integrity at an early stage of left ventricular hypertrophy. However, conventional protocols involving a long acquisition time for dynamic imaging reduce the animal survival rate and thus make longitudinal analysis difficult. The goal of this work was to develop a procedure to reduce the total acquisition time by selecting non-uniform acquisition times for projection views while maintaining the accuracy and precision of estimated physiologic parameters...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28417127/on-the-formation-of-stripe-sigma-and-honeycomb-phases-in-a-core-corona-system
#4
Harini Pattabhiraman, Marjolein Dijkstra
Using Monte Carlo simulations and free-energy calculations, we investigate the phase behaviour of a two-dimensional core-corona system. We model this system as particles consisting of an impenetrable hard core of diameter σHD surrounded by a purely repulsive soft corona of diameter δ = 1.95σHD. At low densities, we observe the spontaneous formation of a phase with a stripe texture as well as a honeycomb-like phase driven by both energy and entropy considerations. At high densities, we find that a two-dimensional analogue of the periodic sigma phase, considered as an approximant of dodecagonal quasicrystals, is energetically stabilised with respect to two distinct dodecagonal quasicrystals, namely, a square-triangle tiling and a square-triangle-shield tiling...
April 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/28404685/rising-maternal-circulating-gh-during-murine-pregnancy-suggests-placental-regulation
#5
Kathryn L Gatford, Beverly Muhlhausler, Lili Huang, Pamela S-L Sim, Claire T Roberts, Johannes D Veldhuis, Chen Chen
Placenta-derived hormones including growth hormone (GH) in humans contribute to maternal adaptation to pregnancy, and intermittent maternal GH administration increases fetal growth in several species. Both patterns and abundance of circulating GH are important for its activity, but their changes during pregnancy have only been reported in humans and rats. The aim of the present study was to characterise circulating profiles and secretory characteristics of GH in non-pregnant female mice and throughout murine pregnancy...
April 12, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28368821/drawing-large-graphs-by-multilevel-maxent-stress-optimization
#6
Henning Meyerhenke, Martin Nollenburg, Christian Schulz
Drawing large graphs appropriately is an important step for the visual analysis of data from real-world networks. Here we present a novel multilevel algorithm to compute a graph layout with respect to the maxent-stress metric proposed by Gansner et al. (2013) that combines layout stress and entropy. As opposed to previous work, we do not solve the resulting linear systems of the maxent-stress metric with a typical numerical solver. Instead we use a simple local iterative scheme within a multilevel approach...
March 29, 2017: IEEE Transactions on Visualization and Computer Graphics
https://www.readbyqxmd.com/read/28361150/ab-initio-calculation-of-the-attempt-frequency-of-oxygen-diffusion-in-pure-and-samarium-doped-ceria
#7
Julius Koettgen, Tobias Zacherle, Steffen Grieshammer, Manfred Martin
The rate of oxygen ion jumps in a solid oxide depends not only on the activation energy but also on the pre-exponential factor of diffusion. In order to allow a fully ab initio prediction of the oxygen ion conductivity in pure and samarium doped ceria, we calculated the attempt frequency for an oxygen ion jump from first principles combining DFT+U, the NEB method, phonon calculations and the transition state theory. Different definitions of the jump attempt frequency are presented. The equivalence of the Eyring and the Vineyard method is shown without restriction to the Gamma point...
April 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28358124/domain-specific-interactions-between-mln8237-and-human-serum-albumin-estimated-by-std-and-waterlogsy-nmr-itc-spectroscopic-and-docking-techniques
#8
Hongqin Yang, Jiuyang Liu, Yanmei Huang, Rui Gao, Bin Tang, Shanshan Li, Jiawei He, Hui Li
Alisertib (MLN8237) is an orally administered inhibitor of Aurora A kinase. This small-molecule inhibitor is under clinical or pre-clinical phase for the treatment of advanced malignancies. The present study provides a detailed characterization of the interaction of MLN8237 with a drug transport protein called human serum albumin (HSA). STD and WaterLOGSY nuclear magnetic resonance (NMR)-binding studies were conducted first to confirm the binding of MLN8237 to HSA. In the ligand orientation assay, the binding sites of MLN8237 were validated through two site-specific spy molecules (warfarin sodium and ibuprofen, which are two known site-selective probes) by using STD and WaterLOGSY NMR competition techniques...
March 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28355485/rigidity-theory-based-approximation-of-vibrational-entropy-changes-upon-binding-to-biomolecules
#9
Holger Gohlke, Ido Y Ben-Shalom, Hannes Kopitz, Stefania Pfeiffer-Marek, Karl-Heinz Baringhaus
We introduce a computationally efficient approximation of vibrational entropy changes (ΔSvib) upon binding to biomolecules based on rigidity theory. From constraint network representations of the binding partners, ΔSvib is estimated from changes in the number of low frequency ("spongy") modes with respect to changes in the networks' coordination number. Compared to ΔSvib computed by normal-mode analysis (NMA), our approach yields significant and good to fair correlations for data sets of protein-protein and protein-ligand complexes...
April 3, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28349343/characterization-and-evaluation-of-a-peptide-based-sirna-delivery-system-in-vitro
#10
Baoling Chen, Kimoon Yoo, Wen Xu, Ran Pan, Xiao Xia Han, P Chen
Since its inception more than a decade ago, gene silencing mediated by double-stranded small interfering RNA (siRNA) has been widely investigated as a potential therapeutic approach for a variety of diseases. However, the use of siRNA is hampered by its rapid degradation and poor cellular uptake in vitro and in vivo. Recently, peptide-based carriers have been applied to siRNA delivery, as an alternative to the traditional delivery systems. Here, a histidine-containing amphipathic amino acid pairing peptide, C6M3, which can form complexes with siRNA, was used as a new siRNA delivery system...
March 27, 2017: Drug Delivery and Translational Research
https://www.readbyqxmd.com/read/28335461/design-and-validation-of-a-low-cost-portable-device-to-quantify-postural-stability
#11
Yong Zhu
Measurement of the displacement of the center-of-pressure (COP) is an important tool used in biomechanics to assess postural stability and human balance. The goal of this research was to design and validate a low-cost portable device that can offer a quick indication of the state of postural stability and human balance related conditions. Approximate entropy (ApEn) values reflecting the amount of irregularity hiding in COP oscillations were used to calculate the index. The prototype adopted a portable design using the measurements of the load cells located at the four corners of a low-cost force platform...
March 18, 2017: Sensors
https://www.readbyqxmd.com/read/28330366/phase-behaviour-of-quasicrystal-forming-systems-of-core-corona-particles
#12
Harini Pattabhiraman, Marjolein Dijkstra
Using Monte Carlo simulations and free-energy calculations, we study the phase behaviour of a two-dimensional system of particles interacting with a hard core of diameter σHD and a repulsive square shoulder potential. The interest in this system lies in the formation of quasicrystals of different symmetries at specific square-shoulder widths δ as previously reported by Dotera et al. [Nature 506, 208 (2014)]. However, an insight into other possible periodic phases formed in these systems and the thermodynamic stability of both the periodic and quasicrystal phases is yet to be addressed...
March 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28316861/complexity-analysis-of-electroencephalogram-dynamics-in-patients-with-parkinson-s-disease
#13
Guotao Liu, Yanping Zhang, Zhenghui Hu, Xiuquan Du, Wanqing Wu, Chenchu Xu, Xiangyang Wang, Shuo Li
In this study, a new combination scheme has been proposed for detecting Parkinson's disease (PD) from electroencephalogram (EEG) signal recorded from normal subjects and PD patients. The scheme is based on discrete wavelet transform (DWT), sample entropy (SampEn), and the three-way decision model in analysis of EEG signal. The EEG signal is noisy and nonstationary, and, as a consequence, it becomes difficult to distinguish it visually. However, the scheme is a well-established methodology in analysis of EEG signal in three stages...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28297917/free-energy-of-singular-sticky-sphere-clusters
#14
Yoav Kallus, Miranda Holmes-Cerfon
Networks of particles connected by springs model many condensed-matter systems, from colloids interacting with a short-range potential and complex fluids near jamming, to self-assembled lattices and various metamaterials. Under small thermal fluctuations the vibrational entropy of a ground state is given by the harmonic approximation if it has no zero-frequency vibrational modes, yet such singular modes are at the epicenter of many interesting behaviors in the systems above. We consider a system of N spherical particles, and directly account for the singularities that arise in the sticky limit where the pairwise interaction is strong and short ranged...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28285644/effects-of-transdermal-testosterone-gel-or-an-aromatase-inhibitor-on-serum-concentration-and-pulsatility-of-growth-hormone-in-older-men-with-age-related-low-testosterone
#15
Jenny Pena Dias, Johannes D Veldhuis, Olga Carlson, Michelle Shardell, Chee W Chia, Denise Melvin, Josephine M Egan, Shehzad Basaria
Growth hormone is the major regulator of growth and body composition. Pulsatile GH secretion declines exponentially with age. Testosterone replacement is being increasingly offered to older men with age-related low testosterone. Testosterone administration has been shown to stimulate GH secretion. However, little is known about the effect of testosterone aromatization to estradiol on GH pulsatility and its impact on IGF-1 in older men. OBJECTIVE: This randomized controlled proof-of-concept trial investigated the relative effects of testosterone and estradiol on GH pulsatility and IGF-1 in older men with low testosterone...
April 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28275778/a-thermodynamical-and-structural-study-on-the-complexation-of-trivalent-lanthanides-with-a-polycarboxylate-based-concrete-superplasticizer
#16
Daniel R Fröhlich, Martin M Maiwald, Franziska Taube, Johann Plank, Petra J Panak
The complexation of trivalent lanthanides with a commercial polycarboxylate based concrete superplasticizer (Glenium® 51) is investigated using different spectroscopic techniques. Time-resolved laser fluorescence spectroscopy (TRLFS) in combination with a charge neutralization model is used to determine temperature dependent conditional stability constants (log β'(T)) for the complexation of Eu(iii) with Glenium® 51 in 0.1 mol kg(-1) NaCl solution in the temperature range of 20-90 °C. Only one complex species is observed, and log β'(T) (given in kg per mol eq) shows a very slight increase with temperature from 7...
March 9, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28269675/effect-of-embedding-dimension-on-complexity-measures-in-identifying-arrhythmia
#17
Radhagayathri K Udhayakumar, Chandan Karmakar, Peng Li, Marimuthu Palaniswami
Entropy measures like Approximate entropy (ApEn) and Sample entropy (SampEn) are well established tools to analyze Heart Rate Variability (HRV) data. Critical parameters involved in these computations namely embedding dimension m and tolerance r are in most cases assumed to be 2 and 0.2*signal SD (standard devaition) respectively. Such assumptions do not work fairly across data sets and thus create misleading results in many cases. Problems with r have been addressed with the advent of newer entropy measures like Permutation entropy (PE), Fuzzy entropy (FuzzyEn) and Distribution entropy (DistEn) that simply eliminate, modify or replace r from calculations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268915/clinical-viability-of-carotid-plaque-strain-estimation-using-b-mode-ultrasound-image-sequences
#18
Amir A Khan, Joseph C Hecker, Brajesh K Lal, Siddhartha Sikdar
It is estimated that approximately 30% of ischemic strokes are caused by rupture of plaque in the carotid artery. Development of techniques focusing on identifying plaques that are vulnerable to rupture is thus indispensable for stroke prevention. Recent studies have demonstrated that motion analysis of plaques from B-mode and RF ultrasound (US) image sequences can be used to estimate plaque strain. However, viability of these methods in a clinical setting, with variable acquisition protocols, has not been demonstrated yet...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28257094/online-detection-of-driver-fatigue-using-steering-wheel-angles-for-real-driving-conditions
#19
Zuojin Li, Shengbo Eben Li, Renjie Li, Bo Cheng, Jinliang Shi
This paper presents a drowsiness on-line detection system for monitoring driver fatigue level under real driving conditions, based on the data of steering wheel angles (SWA) collected from sensors mounted on the steering lever. The proposed system firstly extracts approximate entropy (ApEn)featuresfromfixedslidingwindowsonreal-timesteeringwheelanglestimeseries. Afterthat, this system linearizes the ApEn features series through an adaptive piecewise linear fitting using a given deviation. Then, the detection system calculates the warping distance between the linear features series of the sample data...
March 2, 2017: Sensors
https://www.readbyqxmd.com/read/28255330/comparison-of-different-features-and-classifiers-for-driver-fatigue-detection-based-on-a-single-eeg-channel
#20
Jianfeng Hu
Driver fatigue has become an important factor to traffic accidents worldwide, and effective detection of driver fatigue has major significance for public health. The purpose method employs entropy measures for feature extraction from a single electroencephalogram (EEG) channel. Four types of entropies measures, sample entropy (SE), fuzzy entropy (FE), approximate entropy (AE), and spectral entropy (PE), were deployed for the analysis of original EEG signal and compared by ten state-of-the-art classifiers. Results indicate that optimal performance of single channel is achieved using a combination of channel CP4, feature FE, and classifier Random Forest (RF)...
2017: Computational and Mathematical Methods in Medicine
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