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autologous blood transfusion

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https://www.readbyqxmd.com/read/29674501/evaluation-of-serum-markers-for-improved-detection-of-autologous-blood-transfusions
#1
Holly D Cox, Geoffrey D Miller, Auriella Lai, Dan Cushman, Tomas Ganz, Daniel Eichner
No abstract text is available yet for this article.
April 19, 2018: Haematologica
https://www.readbyqxmd.com/read/29621963/detecting-autologous-blood-transfusion-in-doping-control-biomarkers-of-blood-aging-and-storage-measured-by-flow-cytofluorimetry
#2
Francesco Botre, Roberta Acciarini, Ilenia De Benedittis, Xavier de la Torre, Daniela Pirri, Mariangela Prete, Alessandra Stampella, Enza Vernucci
Backgorund: Blood transfusions are banned by the World Anti-Doping Agency as a form of "blood doping". A method of detection of homologous blood transfusion (HBT) has been implemented by the accredited anti-doping laboratories worldwide; however, no internationally recognized method has been finalized so far for the direct detection of autologous blood transfusions, which can at present be revealed only by targeted longitudinal profiling of key blood parameters. METHODS: The present article reports the results of an investigation aimed to pre-select potential biomarkers of blood aging and storage that can be measured to identify the presence in the sample of re-infused blood...
April 5, 2018: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29608323/recovery-of-autologous-sickle-cells-by-hypotonic-wash
#3
Emily Wilson, Kelly Kezeor, Monica Crosby
It is important to isolate autologous red blood cells (RBCs) from transfused RBCs in samples from recently transfused patients to ensure that accurate serologic results are obtained. Typically, this isolation can be performed using methods that separate patient reticulocytes from transfused, older donor RBCs. Patients with sickle cell disease (SCD), however, characteristically have RBCs with altered membrane and morphological features, causing their RBCs to take on a sickle-shape appearance different from the biconcave disc-shape appearance of "normal" RBCs...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29608321/management-of-pregnancy-sensitized-with-anti-inb-with-monocyte-monolayer-assay-and-maternal-blood-donation
#4
Raj Shree, Kimberly K Ma, Lay S Er, Meghan Delaney
Maternal red blood cell (RBC) alloantibodies can cause hemolytic disease of the fetus and newborn (HDFN). Although much is described about common antibodies associated with HDFN, management of a pregnancy complicated by a maternal rare antibody presents several challenges related to assessment of fetal anemia risk, availability of blood for transfusion to the mother and/or the fetus or newborn if needed, and planning for delivery in the case of maternal hemorrhage. Here we report the laboratory medicine workup of a patient who presented for obstetrical care in the United States in the third trimester and had a rare antibody (anti-Inb)...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29608319/warm-autoadsorption-using-zzap
#5
Farai M Tsimba-Chitsva, Amy Caballero, Becky Svatora
The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion practices such as the issuing of "least incompatible" red blood cells (RBCs) without a complete antibody workup is potentially unsafe for patients. Several autoadsorption methods can be used to remove autoantibody reactivity. ZZAP treatment of autologous RBCs is an efficient way to prepare the cells for autoadsorption. Autoadsorbed serum or plasma can then be used to remove autoantibody reactivity and identify clinically significant alloantibodies...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29606583/cost-analysis-of-enhanced-recovery-after-surgery-in-microvascular-breast-reconstruction
#6
Christine Oh, James Moriarty, Bijan J Borah, Kristin C Mara, William S Harmsen, Michel Saint-Cyr, Valerie Lemaine
BACKGROUND: Enhanced recovery after surgery (ERAS) pathways have been shown in multiple surgical specialties to decrease hospital length of stay (LOS) after surgery. ERAS in breast reconstruction has been found to decrease hospital LOS and inpatient opioid use. ERAS protocols can facilitate a patient's recovery and can potentially increase the quality of care while decreasing costs. METHODS: A standardized ERAS pathway was developed through multidisciplinary collaboration...
March 2, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29605509/the-effects-of-lower-cd34-yields-after-lowe-dose-g-csf-induction-on-long-term-autologous-stem-cell-transplantation-outcome-a-single-center-study
#7
Mohammad Vaezi, Mohammad Shakouri, Maryam Souri, Mohammad Amin Setaredan, Seyed Asadollah Mossavi, Saeed Mohammadi, Kamran Alimoghaddam, Ardeshir Ghavamzadeh
Peripheral blood stem cell transplantation (PBSCT) is an effective treatment for hematological malignancies. Mobilization of peripheral blood stem cells performs in different ways among transplantation centers. Since the Effects of lower CD34+ cells dose after low dose G-CSF induction on autologous stem cell transplantation outcomes are not studied much, so this study was performed for this purpose. 735 autologous stem cell transplanted patients with diagnoses of multiple myeloma (n = 330), Hodgkin lymphoma (n = 200), non-Hodgkin lymphoma (n = 129), acute myeloid leukemia (n = 54) and solid tumors (n = 22) were retrospectively evaluated...
March 23, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29602707/neutrophil-extracellular-traps-were-released-during-intraoperative-blood-salvage-in-posterior-lumbar-surgery
#8
Li Zheng, Ming Tian, Ye Zhang, Peng Dong, He Yang
The formation of neutrophil extracellular traps (NETs) has been associated with endothelial damage and severe pulmonary dysfunction. The present study aimed to investigate whether this NETosis occurs during intraoperative blood salvage (IBS), and whether the washing procedures before re-transfusion of autologous blood could remove the NET components, including DNA, histones, and myeloperoxidase. The study was performed using blood samples from 20 patients who underwent posterior lumbar surgery at the Beijing Friendship Hospital...
March 14, 2018: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29582746/intraoperative-cell-salvage-with-autologous-transfusion-in-elective-right-or-repeat-hepatectomy-a-propensity-score-matched-case-control-analysis
#9
Thomas Zacharias, Erich Ahlschwede, Nicole Dufour, Florence Romain, Odile Theissen-Laval
BACKGROUND: Liver resection may be associated with substantial blood loss, and cell saver use has been recommended for patients at high risk. We performed a study to compare the allogenic erythrocyte transfusion rate after liver resection between patients who had intraoperative cell salvage with a cell saver device versus patients who did not. Our hypothesis was that cell salvage with autologous transfusion would reduce the allogenic blood transfusion rate. METHODS: Cell salvage was used selectively in patients at high risk for intraoperative blood loss based on preoperatively known predictors: right and repeat hepatectomy...
April 2018: Canadian Journal of Surgery. Journal Canadien de Chirurgie
https://www.readbyqxmd.com/read/29577348/preoperative-autologous-blood-collection-before-bone-marrow-harvests-in-haploidentical-related-donors-is-it-justified
#10
Komal Arora, James Kelley, Fernando Martinez, Ashok Tholpady
BACKGROUND: With the increasing safety of allogeneic blood supply and declining need for transfusion due to patient blood management, the practice of preoperative autologous donation (PAD) continues to decline. The practice gained popularity during the 1980s and 1990s with the emergence of transfusion-transmitted human immunodeficiency virus and hepatitis C. At the peak of this public concern, the National Marrow Donor Program recommended that marrow donors have 1 to 3 autologous units of blood collected before their marrow harvest to minimize the likelihood of allogeneic transfusion...
March 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29577324/transfusion-of-autologous-extracellular-vesicles-from-stored-red-blood-cells-does-not-affect-coagulation-in-a-model-of-human-endotoxemia
#11
Anna L Peters, Alexander P J Vlaar, Robin van Bruggen, Dirk de Korte, Joost C M Meijers, Rienk Nieuwland, Nicole P Juffermans
BACKGROUND: Red blood cell (RBC) transfusion has been related to thromboembolic events. Microvesicles in the RBC product may support coagulation because they have procoagulant effects in vitro. We investigated whether transfusion of RBCs containing extracellular vesicles promotes coagulation in human recipients. As transfusion is mostly administered to ill patients, we used a model of endotoxemia. STUDY DESIGN AND METHODS: Eighteen healthy volunteers were randomized to receive either saline or fresh (2 days stored) or stored autologous (35 days stored) RBC transfusion (Dutch Trial Register: NTR4455)...
March 25, 2018: Transfusion
https://www.readbyqxmd.com/read/29572786/changes-in-hemoglobin-profile-reflect-autologous-blood-transfusion-misuse-in-sports
#12
Nicola Lamberti, Alessia Finotti, Jessica Gasparello, Ilaria Lampronti, Christel Zambon, Lucia Carmela Cosenza, Enrica Fabbri, Nicoletta Bianchi, Francesca Dalla Corte, Maurizio Govoni, Roberto Reverberi, Roberto Gambari, Fabio Manfredini
The changes in hemoglobin (Hb) profile following autologous blood transfusion (ABT) for the first time were studied for anti-doping purposes. Twenty-four healthy, trained male subjects (aged 18‒40) were enrolled and randomized into either the transfusion (T) or control (C) groups. Blood samples were taken from the T subjects at baseline, after withdrawal and reinfusion of 450 ml of refrigerated or cryopreserved blood, and from C subjects at the same time points. Hematological variables (Complete blood count, Reticulocytes, Immature Reticulocytes Fraction, Red-cell Distribution Width, OFF-hr score) were measured...
March 23, 2018: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/29556115/does-blood-transfusion-type-affect-complication-and-length-of-stay-following-same-day-bilateral-total-knee-arthroplasty
#13
Vasileios G Soranoglou, Lazaros A Poultsides, Florian Wanivenhaus, Allina A Nocon, Georgios K Triantafyllopoulos, Peter K Sculco, Stavros G Memtsoudis, Thomas P Sculco
Same-day Bilateral Total Knee Arthroplasty (BTKA) safety is still controversial. The aim of this study was to examine the association of blood transfusion type (pure autologous, pure allogeneic, and combined) with complication and prolonged length of stay (PLOS) following same-day BTKA. 649 consecutive patients were retrospectively identified over a two-year period. Pure allogeneic transfusions were associated with increased odds of minor complication when compared to patients who had pure autologous transfusions...
June 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29550804/autologous-cord-blood-transfusion-in-preterm-infants-could-its-humoral-effect-be-the-kez-to-control-prematurity-related-complications-a-preliminary-study
#14
M Kotowski, Z Litwinska, P Klos, E Pius-Sadowska, E Zagrodnik-Ulan, P Ustianowski, J Rudnicki, B Machalinski
Umbilical cord blood (UCB), rich in stem/progenitor cells, is partially eliminated from the bloodstream during childbirth because the cord is immediately clamped. We hypothesize that transfusion of autologous UCB to premature infants after delivery could serve as an adjuvant modality for preventing the development of prematurity-related complications. We randomly enrolled 20 preterm infants born before 32 weeks of gestational age (GA), all of whom developed anemia, necessitating transfusion of red blood cells (RBCs)...
December 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29526337/effect-of-age-of-red-cells-for-transfusion-on-patient-outcomes-a-systematic-review-and-meta-analysis
#15
REVIEW
Zoe K McQuilten, Craig J French, Alistair Nichol, Alisa Higgins, David J Cooper
Longer storage duration of red blood cell (RBC) units prior to transfusion has been associated with worse outcomes in observational studies. We performed a systematic review, including recently published randomized trials, to determine if storage age of RBCs is associated with mortality, morbidity or adverse events in patients. Searches were performed up to 21st July 2017 in Medline (OvidSP), 20 July in EMBASE (OvidSP) and June 2017 in Cochrane Library. Eligible studies were randomized controlled trials comparing transfusion of fresher or freshest available with older or standard issue RBCs...
February 17, 2018: Transfusion Medicine Reviews
https://www.readbyqxmd.com/read/29515065/-efficacy-and-safety-of-biosimilar-filgrastim-for-autologous-peripheral-blood-stem-cell-harvest-and-transplantation-a-single-institutional-retrospective-analysis
#16
Masaki Iino, Takeo Yamamoto
Three biosimilar filgrastim products are currently available in Japan. Among these, the safety and efficacy of two imported drugs for autologous peripheral blood stem cell harvest (autoPBSCH) and autologous peripheral blood stem cell transplantation (autoPBSCT) have been studied widely; however, evidence of the safety and efficacy of domestically manufactured filgrastim is limited. Therefore, we compared the efficacy and safety of domestic biosimilar filgrastim (BF1, n=23) with those of originator filgrastim (OF, n=21) for autoPBSCH and autoPBSCT...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29505447/the-association-of-targeted-cell-salvage-blood-transfusion-during-cesarean-delivery-with-allogeneic-packed-red-blood-cell-transfusions-in-a-maternity-hospital-in-china
#17
Haiya Yan, Ling-Qun Hu, Yun Wu, Qihui Fan, Cynthia A Wong, Robert J McCarthy
BACKGROUND: Autologous transfusion of intraoperative cell salvage blood may be a potential method to decrease the need for allogeneic packed red blood cell transfusions after cesarean delivery, although there are limited data on the benefits of this method. This study evaluated the implementation of targeted intraoperative cell salvage during cesarean delivery in women at increased risk for hemorrhage at the Women's and Children's Hospital in Ningbo, China. METHODS: All women who underwent cesarean delivery >28 weeks of gestation were included in the study...
March 1, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29500133/current-status-of-clinical-transfusion-practice-in-sichuan-china-a-cross-sectional-survey
#18
Rong Zhang, Zhao Wu, Zongkui Wang, Shengliang Ye, Changqing Li, Li Lu, Ya Wang, Shaoqin Rao
OBJECTIVE: The safety and effectiveness of clinical transfusion are highly associated with clinical blood transfusion level. A survey was conducted with the aim of providing references to improve the level of clinical blood transfusion. STUDY DESIGN AND METHODS: A survey was undertaken by means of a questionnaire which consisted of hospitals' basic conditions, utilization of blood products and application of autologous blood transfusion in hospitals with scale, geographic and religious diversity in Sichuan, China...
December 9, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/29482624/one-step-genetic-correction-of-hemoglobin-e-beta-thalassemia-patient-derived-ipscs-by-the-crispr-cas9-system
#19
Methichit Wattanapanitch, Nattaya Damkham, Ponthip Potirat, Kongtana Trakarnsanga, Montira Janan, Yaowalak U-Pratya, Pakpoom Kheolamai, Nuttha Klincumhom, Surapol Issaragrisil
BACKGROUND: Thalassemia is the most common genetic disease worldwide; those with severe disease require lifelong blood transfusion and iron chelation therapy. The definitive cure for thalassemia is allogeneic hematopoietic stem cell transplantation, which is limited due to lack of HLA-matched donors and the risk of post-transplant complications. Induced pluripotent stem cell (iPSC) technology offers prospects for autologous cell-based therapy which could avoid the immunological problems...
February 26, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29472357/plerixafor-enables-the-safe-rapid-efficient-mobilization-of-haematopoietic-stem-cells-in-sickle-cell-disease-patients-after-exchange-transfusion
#20
Chantal Lagresle-Peyrou, François Lefrère, Elisa Magrin, Jean-Antoine Ribeil, Oriana Romano, Leslie Weber, Alessandra Magnani, Hanem Sadek, Clémence Plantier, Aurélie Gabrion, Brigitte Ternaux, Tristan Félix, Chloé Couzin, Aurélie Stanislas, Jean-Marc Tréluyer, Lionel Lamhaut, Laure Joseph, Marianne Delville, Annarita Miccio, Isabelle André-Schmutz, Marina Cavazzana
Sickle cell disease is characterized by chronic anaemia and vaso-occlusive crises, which eventually lead to multi-organ damage and premature death. Haematopoietic stem cell transplantation is the only curative treatment but it is limited by toxicity and poor availability of HLA-compatible donors. A gene therapy approach based on the autologous transplantation of lentiviral-corrected haematopoietic stem and progenitor cells was shown to be efficacious in one patient. However, alterations of the bone marrow environment and the red blood cells' properties hamper the harvesting and immunoselection of patient stem cells from bone marrow...
February 22, 2018: Haematologica
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