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autologous blood transfusion

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https://www.readbyqxmd.com/read/28197273/clinical-and-surgical-strategies-for-avoiding-or-reducing-allogeneic-blood-transfusions
#1
Antonio Alceu Dos Santos, Jose Francisco Baumgratz, Jose Henrique Andrade Vila, Rodrigo Moreira Castro, Rodrigo Freire Bezerra
Blood transfusions have still been used as a standard therapy to treat severe anemia. Current evidences point to both excessive allogeneic blood consumption and decreased donations, which result in reduced stocks in blood banks. Several studies have increasingly suggested a more restrictive transfusion practice for blood products. Currently, a number of autologous blood conservation protocols in surgeries have been noted. We report a case of severe anemia with 2.9 g/dL hemoglobin, which was successfully handled without using the standard therapy to treat anemia with hemotransfusions...
April 2016: Cardiology Research
https://www.readbyqxmd.com/read/28156546/blood-transfusions-at-end-of-life-for-stem-cell-transplant-patients
#2
Joseph D Ma, Sandahl H Nelson, Carolyn Revta, Gary T Buckholz, Carolyn M Mulroney, Eric Roeland
: 115 Background: Transfusions are an essential palliative tool in the stem cell transplant (SCT) population. Limited data exist regarding transfusion practices at end-of-life for SCT patients and whether these practices may limit enrollment in hospice. METHODS: A retrospective chart review was conducted of deceased patients with hematologic malignancies who underwent SCT at an academic medical center from 2011 to 2015. The primary objective was to determine the difference between the dates of last transfusion and death in patients enrolled and not enrolled in hospice...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28148896/investigated-the-safety-of-intra-renal-arterial-transfusion-of-autologous-cd34-cells-and-time-courses-of-creatinine-levels-endothelial-dysfunction-biomarkers-and-micro-rnas-in-chronic-kidney-disease-patients-phase-i-clinical-trial
#3
Mel S Lee, Fan-Yen Lee, Yung-Lung Chen, Pei-Hsun Sung, Hsin-Ju Chiang, Kuan-Hung Chen, Tien-Hung Huang, Yi-Ling Chen, John Y Chiang, Tsung-Cheng Yin, Hsueh-Wen Chang, Hon-Kan Yip
This was a phase I clinical trial to investigate the safety of autologous peripheral-blood-derived CD34+ cell therapy for patients with chronic kidney disease (CKD-treatment) (i.e., at Stages III and IV). Between November 2014 and October 2015, a total of 10 study patients were prospectively enrolled into this phase I trial. Patients who failed to enroll into the trial in the initial state of eligibility assessment were served as CKD-control group (n = 9). The health-control group was composed of 10 volunteers for the purposes of comparing (1) circulation level of endothelial progenitor cells (EPCs), (2) angiogenesis ability, and (3) anti-apoptotic miRNAs between healthy subjects and CKD patients...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28135341/association-between-allogeneic-or-autologous-blood-transfusion-and-survival-in-patients-after-radical-prostatectomy-a-systematic-review-and-meta-analysis
#4
Su-Liang Li, Yun Ye, Xiao-Hua Yuan
BACKGROUND: A number of studies have investigated the effect of perioperative blood transfusion (PBT) for patients after radical prostatectomy (RP), with some reporting conflicting results. A systematic review of the literature and a meta-analysis were conducted to explore the association between PBT (autologous or allogeneic) and biochemical recurrence-free survival (BRFS), overall survival (OS) and cancer-specific survival (CSS) in patients undergoing RP. METHODS: The PubMed, Medline, Cochrane Library, and Embase databases were searched for published controlled clinical studies on perioperative allogeneic or autologous blood transfusion (BT) and patient survival after RP...
2017: PloS One
https://www.readbyqxmd.com/read/28128496/allogeneic-hematopoietic-stem-cell-transplant-recipients-and-parasitic-diseases-a-review-of-the-literature-of-clinical-cases-and-perspectives-to-screen-and-follow-up-active-and-latent-chronic-infections
#5
REVIEW
Silvia Fabiani, Simona Fortunato, Mario Petrini, Fabrizui Bruschi
BACKGROUND: Allogeneic hematopoietic stem cell transplant (HSCT) recipients are at substantial risk for a variety of infections depending upon numerous factors, such as degree of immunosuppression, host factors, and period after transplantation. Bacterial, fungal, viral, as well as parasitic infections can occur with high morbidity and mortality. OBJECTIVES: The aim of this study was to evaluate the magnitude of the occurrence of parasitic infections in allogeneic HSCT recipients...
January 27, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28126252/characteristics-and-operative-treatment-of-extremely-giant-liver-hemangioma-20%C3%A2-cm
#6
Xiaolei Liu, Zhiying Yang, Haidong Tan, Liguo Liu, Li Xu, Yongliang Sun, Shuang Si, Jia Huang, Wenying Zhou
BACKGROUND: Giant liver hemangioma >20 cm may cause severe complications; therefore, operative treatment can be highly difficult and risky. No studies have been performed to determine the characteristics of this subgroup. METHODS: A retrospective study was performed on 141 patients who underwent operative treatment for liver hemangioma. The patients were divided into an extremely giant hemangioma group (>20 cm, 36 cases) and a giant hemangioma group (>10 cm but <20 cm, 105 cases)...
January 23, 2017: Surgery
https://www.readbyqxmd.com/read/28107785/blood-management-strategies-to-reduce-transfusions-after-elective-lower-extremity-joint-arthroplasty-surgeries
#7
Ankit Kansagra, Chester Andrzejewski, Robert Krushell, Andrew Lehman, Jordan Greenbaum, Paul Visintainer, Joan McGirr, Kathleen Mahoney, Darlene Cloutier, Alice Ehresman, Mihaela S Stefan
Blood loss associated with lower-extremity total joint arthroplasty (TJA) often results in anemia and the need for red blood cell transfusions (RBCTs). This article reports on a quality improvement initiative aimed at improving blood management strategies in patients undergoing TJA. A multifaceted intervention (preoperative anemia assessment, use of tranexamic acid, discouragement of autologous preoperative blood collection, restrictive RBCT protocols) was implemented. The results were stratified into 3 intervention periods: 1, pre; 2, peri; and 3, post...
January 1, 2017: American Journal of Medical Quality: the Official Journal of the American College of Medical Quality
https://www.readbyqxmd.com/read/28105211/diagnostic-and-therapeutic-approaches-to-multiple-myeloma-patients-real-world-data-from-representative-multicentre-treatment-surveys-in-germany-between-2008-and-2011
#8
Thomas M Moehler, Maximilian Merz, Lenka Kellermann, Hartmut Goldschmidt, Wolfgang Knauf
A survey was conducted to investigate the standard of care for multiple myeloma in Germany, in order to clarify the status of implementation of international and national treatment guidelines. In addition, the changes in disease management over time were investigated by comparison with surveys conducted in 2008 and 2009. The survey captured a representative sample of 478 myeloma patients with a mean age of 67.9 years across various stages of the disease. Diagnostic approaches, prognostic aspects and treatment decisions were evaluated based on a survey conducted in 2011 in 58 representative centres in Germany, including university and non-university hospitals and office-based haematologists...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28099421/estimation-of-adult-and-neonatal-rbc-lifespans-in-anemic-neonates-using-rbcs-labeled-at-several-discrete-biotin-densities
#9
Denison J Kuruvilla, John A Widness, Demet Nalbant, Robert L Schmidt, Donald M Mock, Guohua An, Peter Veng-Pedersen
BACKGROUND: Prior conclusions that autologous neonatal red blood cells (RBC) have substantially shorter lifespans than allogeneic adult RBCs were not based on direct comparison of autologous neonatal vs. allogeneic adult RBCs performed concurrently in the same infant. Biotin labeling of autologous neonatal RBCs and allogeneic adult donor RBCs permits concurrent direct comparison of autologous vs. allogeneic RBC lifespan. METHODS: RBCs from 15 allogeneic adult donors and from 15 very low birth weight (VLBW) neonates were labeled at separate biotin densities and transfused simultaneously into the 15 neonates...
January 18, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28088945/clinical-analysis-of-thoracoscopic-surgery-combined-with-intraoperative-autologous-blood-transfusion-in-the-treatment-of-traumatic-hemothorax
#10
Hu-Sai Ma, Ju-Hua Ma, Feng-Lai Xue, Xiang-Ning Fu, Ni Zhang
From January 2013 to January 2015, 19 patients of traumatic hemothorax with hemorrhagic shock were treated in our department by thoracoscopic surgery combined with autologous blood transfusion. This study retrospectively analyzed the therapeutic effect and shared our experience. The average amount of blood transfused back was 662.41 ml ± 269.15 ml. None of the patients developed transfusion reaction and were all discharged uneventfully. Thoracoscopic surgery combined with autologous blood trans- fusion is effective in the rescue of patients with progressive hemothorax and hemorrhagic shock...
December 1, 2016: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/28065237/predictors-for-massive-blood-loss-during-posterior-correction-of-congenital-scoliosis-in-pre-school-children-a-retrospective-observation
#11
Le Shen, Wei-Yun Chen, Wu-Tao Wang, Hao-Nan Xu, Xue-Rong Yu, Xiu-Hua Zhang, Yu-Guang Huang
Objective To investigate the predictors for massive blood loss during posterior correction of congenital scoliosis in pre-school children. Methods Totally 124 children under six years of age,who received posterior correction of congenital scoliosis,were divided into two groups according to the ratio of intraoperative blood loss (BL) and estimated blood volume (EBV). Massive blood loss was defined as BL/EBV>0.15,and minor or moderate blood loss as BL/EBV≤0.15. All the records,including demographics,intraoperative fluids,pre- or postoperative laboratory parameters,and the length of hospital stay,were compared between these two groups...
December 20, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28032033/benefits-of-the-use-of-blood-conservation-in-scoliosis-surgery
#12
Peter R Loughenbury, Lyeanda Berry, Ben T Brooke, Abhay S Rao, Robert A Dunsmuir, Peter A Millner
AIM: To investigate whether autologous blood transfusion (ABT) drains and intra-operative cell salvage reduced donor blood transfusion requirements during scoliosis surgery. METHODS: Retrospective data collection on transfusion requirements of patients undergoing scoliosis surgery is between January 2006 and March 2010. There were three distinct phases of transfusion practice over this time: Group A received "traditional treatment" with allogeneic red cell transfusion (ARCT) in response to an intra- or post-operative anaemia (Hb < 8 g/dL or a symptomatic anaemia); Group B received intra-operative cell salvage in addition to "traditional treatment"...
December 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28031095/effect-of-point-of-care-hemoglobin-hematocrit-devices-and-autologous-blood-salvage-on-reduction-of-perioperative-allogeneic-blood-transfusion
#13
Wei-Yun Chen, Xue-Rong Yu, Jiao Zhang, Qing Yuan, Yu-Guang Huang
Objective To evaluate the effect of point-of-care hemoglobin/hematocrit (POC HGB/HCT) devices and intraoperative blood salvage on the amount of perioperative allogeneic blood transfusion and blood conservation in clinical practice.Methods A total of 46 378 medical records of 22 selected hospitals were reviewed. The volume of allogeneic red blood cell and plasma, number of patients transfused, number of intraoperative autologous blood salvage, total volume of autologous blood transfusion, and amount of surgery in the year of 2011 and 2013 were tracked...
June 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/27994257/changes-in-cerebral-oxygenation-during-transfusion-therapy
#14
Mumin Hakim, Dmitry Tumin, David P Martin, Walter Samora, Allan C Beebe, Jan E Klamar, Ashley B Hodge, Joseph D Tobias
This study assesses the effects of transfusion of autologous or allogeneic blood on cerebral and tissue oxygenation during spinal surgery. Packed red blood cell transfusions are indicated to improve oxygen delivery to tissues. There are limited data demonstrating changes in tissue oxygenation with blood administration. Tissue (deltoid) and cerebral oxygenation were monitored using near-infrared spectroscopy during spinal surgery in patients. As indicated, cell saver or allogeneic blood was administered. Tissue and cerebral oxygenation were recorded before and after transfusion...
December 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27994256/a-novel-centrifugation-method-using-a-cell-salvage-device-offers-an-alternative-to-the-use-of-leukocyte-depleting-filters-for-autologous-blood-transfusions
#15
Michael Barchilon, Cristina Gaspar, Angela Mexas, Don Nieter
Autotransfusion protocols often use the use of costly filters, such as leukocyte-depleting filters (LDFs), to minimize reinfusion of activated leukocytes and inflammatory mediators associated with reperfusion injury (RI). LDFs are used extensively in hospital settings; however, they represent an additional capital expenditure for hospitals, as well as a constraint on the reinfusion rate of blood products for health-care providers. We compared a commonly used LDF to a novel centrifugation method employing a widely used cell salvage device...
December 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27965248/gender-disparities-in-red-blood-cell-transfusion-in-elective-surgery-a-post-hoc-multicentre-cohort-study
#16
Hans Gombotz, Günter Schreier, Sandra Neubauer, Peter Kastner, Axel Hofmann
OBJECTIVES: A post hoc gender comparison of transfusion-related modifiable risk factors among patients undergoing elective surgery. SETTINGS: 23 Austrian centres randomly selected and stratified by region and level of care. PARTICIPANTS: We consecutively enrolled in total 6530 patients (3465 women and 3065 men); 1491 underwent coronary artery bypass graft (CABG) surgery, 2570 primary unilateral total hip replacement (THR) and 2469 primary unilateral total knee replacement (TKR)...
December 13, 2016: BMJ Open
https://www.readbyqxmd.com/read/27941590/traumatic-hemothorax-blood-contains-elevated-levels-of-microparticles-that-are-prothrombotic-but-inhibit-platelet-aggregation
#17
Thomas A Mitchell, Maryanne C Herzig, Chriselda G Fedyk, Marc A Salhanick, Aaron T Henderson, Bijaya K Parida, Nicolas J Prat, Daniel L Dent, Martin G Schwacha, Andrew P Cap
OBJECTIVES: Autotransfusion of shed blood from traumatic hemothorax is an attractive option for resuscitation of trauma patients in austere environments. However, previous analyses revealed that shed hemothorax (HX) blood is defibrinated, thrombocytopenic, and contains elevated levels of D-dimer. Mixing studies with normal pooled plasma demonstrated hypercoagulability, evoking concern for potentiation of acute traumatic coagulopathy. We hypothesized that induction of coagulopathic changes by shed HX blood may be due to increases in cellular microparticles (MP) and that these may also affect recipient platelet function...
December 9, 2016: Shock
https://www.readbyqxmd.com/read/27941245/prolonged-red-cell-storage-before-transfusion-increases-extravascular-hemolysis
#18
Francesca Rapido, Gary M Brittenham, Sheila Bandyopadhyay, Francesca La Carpia, Camilla L'Acqua, Donald J McMahon, Abdelhadi Rebbaa, Boguslaw S Wojczyk, Jane Netterwald, Hangli Wang, Joseph Schwartz, Andrew Eisenberger, Mark Soffing, Randy Yeh, Chaitanya Divgi, Yelena Z Ginzburg, Beth H Shaz, Sujit Sheth, Richard O Francis, Steven L Spitalnik, Eldad A Hod
BACKGROUND: Some countries have limited the maximum allowable storage duration for red cells to 5 weeks before transfusion. In the US, red blood cells can be stored for up to 6 weeks, but randomized trials have not assessed the effects of this final week of storage on clinical outcomes. METHODS: Sixty healthy adult volunteers were randomized to a single standard, autologous, leukoreduced, packed red cell transfusion after 1, 2, 3, 4, 5, or 6 weeks of storage (n = 10 per group)...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27913130/topical-tranexamic-acid-is-equivalent-to-targeted-preoperative-autologous-blood-donation-in-total-hip-arthroplasty
#19
Maximilian F Kasparek, Martin Faschingbauer, Wenzel Waldstein, Cosima S Boettner, Friedrich Boettner
BACKGROUND: Topical tranexamic acid (TXA) was introduced to replace the previous targeted preoperative autologous blood donation (PABD) program. This study aims to analyze the efficacy of topical TXA compared with targeted PABD in anemic patients undergoing primary total hip arthroplasty (THA). METHODS: Two thousand two hundred fifty-one patients underwent primary THA between 2009 and 2013 using targeted autologous blood donation for 280 anemic patients (12%; Hb <12...
October 31, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/27904574/comparison-of-early-period-results-of-blood-use-in-open-heart-surgery
#20
Serhat Huseyin, Volkan Yuksel, Orkut Guclu, Fatma Nesrin Turan, Suat Canbaz, Turan Ege, Hasan Sunar
BACKGROUND: Various adverse effects of homologous blood transfusion detected particularly in open heart surgery, in which it is frequently used, lead researchers to study on autologous blood use and to evaluate the patient's blood better. Due to the complications of homologous blood transfusion, development of techniques that utilize less transfusion has become inevitable. We aimed to evaluate the effects of acute normovolemic hemodilution (ANH) in patients undergoing open heart surgery...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
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