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intrabdominal sepsis

Rabin Koirala, Naimish Mehta, Vibha Varma, Sorabh Kapoor, Vinay Kumaran, Samiran Nundy
A proportion of the operations performed in a surgical gastroenterology department are unplanned repeat laparotomies for complications of the original procedure. We examined why, in our department, these 'redo' laparotomies were performed and what was their outcome. We retrospectively analyzed 6530 patients operated between September 1996 - December 2010, of these 257 redo laparotomies were performed in 193(2.5 %) patients. There were 138 males and 55 females who had a mean age of 42 years (range 7-68 years)...
June 2015: Indian Journal of Surgery
Bülent Salman, Tonguç Utku Yılmaz, Tugan Tezcaner, Ebru Ofluoğlu Demir, Ozge Tuğçe Paşaoğlu
BACKGROUND: Adiponectin, which has anti-inflammatory features, is an important substance in several metabolic mechanisms. AIMS: The aim of this study is to evauate the effects of exogenous intraperitoneal administration of adiponectin on the survival, intrabdominal adhesion and inflammatory cytokine levels in an experimental sepsis model. STUDY DESIGN: Animal experimentation. METHODS: Ninety rats were divided into a control group, adiponectin group and sham group...
September 2014: Balkan Medical Journal
M Cavallini, M La Torre, M Ferri, V Vitale, P Mercantini, M Dente, V Ziparo
AIM: Pancreatic fistula (PF) represents the main complication (10%-29%) after pancreatic surgery. Soft pancreatic texture with a not dilated pancreatic duct represent the major risk factors for PF. Mortality after pancreaticoduodenectomy (PD) is reported in several large series to be <5%. PF and local sepsis are the main causes of delayed arterial hemorrage with a high mortality rate (14-38%). Therefore, any effort should be implemented in order to reduce the incidence of PF. METHODS: In the present study we have extended the use of the biological adhesive Bioglue® to coat pancreatic resection surface after distal pancreasectomy (DP, N...
October 2012: Minerva Chirurgica
Thekla Poukoulidou, Aikaterini Spyridaki, Ira Mihailidou, Petros Kopterides, Aikaterini Pistiki, Zoi Alexiou, Michael Chrisofos, Ioanna Dimopoulou, Panagiotis Drimoussis, Evangelos J Giamarellos-Bourboulis, Ioannis Koutelidakis, Androniki Marioli, Anna Mega, Stylianos E Orfanos, Maria Theodorakopoulou, Christos Tsironis, Nina Maggina, Vlassios Polychronopoulos, Iraklis Tsangaris
BACKGROUND: Current knowledge on the exact ligand causing expression of TREM-1 on neutrophils and monocytes is limited. The present study aimed at the role of underlying infection and of the causative pathogen in the expression of TREM-1 in sepsis. METHODS: Peripheral venous blood was sampled from 125 patients with sepsis and 88 with severe sepsis/septic shock. The causative pathogen was isolated in 91 patients. Patients were suffering from acute pyelonephritis, community-acquired pneumonia (CAP), intra-abdominal infections (IAIs), primary bacteremia and ventilator-associated pneumonia or hospital-acquired pneumonia (VAP/HAP)...
2011: BMC Infectious Diseases
George Miller, Duke Yim, Michael Macari, Marsha Harris, Peter Shamamian
Endoscopically placed biliary stents have supplanted surgical decompression as the preferred treatment option for patients with obstructive jaundice from advanced pancreatic cancer. An unusual complication of indewelling biliary stents is duodenal perforation into the retroperitoneum. We describe the case of a patient with end-stage pancreatic cancer who presented with an acute abdomen from erosion of a previously placed bile duct stent through the wall of the second portion of the duodenum. Although our patient presented with advanced symptoms, clinical presentations can vary from mild abdominal discomfort and general malaise to overt septic shock...
September 2005: Current Surgery
José Luis Martínez-Ordaz, Pedro Armando Cruz-Olivo, Ericka Chacón-Moya, Mauricio de la Fuente-Lira, Manuel Chavelas-Lluck, Roberto Blanco-Benavides
OBJECTIVE: To compare two techniques of open abdomen management in patients with abdominal sepsis. INTRODUCTION: Some patients with abdominal sepsis will require open abdomen management to avoid abdomen compartment syndrome. We compare use of the Bogota bag with a technique developed at our Institution with a subcutaneous polyethylene bag. METHODS: Thirty nine consecutive patients with abdominal sepsis who were managed with open abdomen. RESULTS: Twenty one patients with Bogota bag and 18 patients with subcutaneous polyethylene bag...
April 2004: Revista de Gastroenterología de México
Silvano Esposito, Sebastiano Leone, Silvana Noviello, Filomena Ianniello
Ascertainment of SBIs plays a central role in their management, which can affect the prognosis, hopefully avoiding an inappropriate antibacterial therapy concerning choice, dosing, timing, duration and route of administration of antibiotics. Different aspects of SBI management were evaluated by interviewing doctors practising in ICU, Surgery and Haematology wards. In the period 16 June - 7 July 2003, 150 doctors, equally distributed by specialty and geographical location, experienced in the management of antibiotic therapy, were interviewed in order to acquire the following information: criteria adopted to define SBIs, presumed incidence, most frequent diagnosis, initial approach to antibiotic therapy (empirical or not, route of administration, mono- or combination therapy), ID consultation request...
June 2004: Le Infezioni in Medicina
A. Marvaso
In the last few years, there has been a continuous, marked increase in serious mycotic infections, with a high incidence of morbidity and mortality especially among patients undergoing surgery in Intensive Therapy Units. Many risk factors are associated with the development of mycotic infections, amongst which the following may be highlighted: immunosuppression, protracted antibiotic treatment, long NPT, serious trauma, central venous catheterization and, in critical patients, a high APACHE II score. Mycotic peritonitis, an increasingly rare complication found in patients undergoing peritoneal dialysis, seems to be linked to gastric or duodenal perforations treated late (> 24 h) or to secondary, chiefly post-operative peritonitis, in the case of anastomotic dehiscences or fistules, and more generally in surgical patients in unstable conditions, i...
2000: Le Infezioni in Medicina
J C Salinas, R Cabezali, J Torcal, L Larrad, R Sousa, M Navarro, R Lozano
BACKGROUND: Intrabdominal sepsis and allogeneic blood transfusion have been associated with a depression of the immune response in patients undergoing surgery. Some authors have considered that an already immunocompromised host is probably primed for a potential detrimental effect of allogeneic blood. The aim of this paper is to ascertain the effects of allogeneic blood transfusion on the lymphocyte subsets and cytokines in septic rats. MATERIALS AND METHODS: Thirty rats were allotted into three groups: Sham-CLP, anesthesia and laparotomy; CLP, cecal ligation and puncture; CLP+BT, CLP and allogeneic blood transfusion...
December 1998: Journal of Surgical Research
J S Solomkin, L A Cotta, J K Brodt, J W Hurst, C K Ogle
Prominent and global abnormalities in chemotactic, oxidative, and microbicidal activity have been identified in neutrophils from patients with severe sepsis. To evaluate the possible contribution of degranulation as the basis for the observed abnormalities, 12 patients with intrabdominal infection were serially studied and neutrophil chemotaxis, enzyme content, and receptors for FMLP were evaluated. There was a significant correlation between chemotactic response to both activated serum and FMLP with the granular enzymes beta-glucuronidase and lysozyme...
May 1984: Journal of Surgical Research
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