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https://www.readbyqxmd.com/read/29342262/preliminary-study-of-1940-nm-thulium-laser-usage-in-peroral-endoscopic-myotomy-for-achalasia
#1
J Liu, Y Jiao, Y Niu, L Yu, M Ji, S Zhang
Esophageal achalasia is a type of motility disorder characterized by incomplete relaxation of lower esophageal sphincter (LES) and absence of esophageal peristalsis. Peroral endoscopic myotomy (POEM) is a new treatment option for achalasia that is less invasive, more effective, and safe as compared to surgery. High-frequency electrotome is commonly used in POEM, but takes longer time to make the tunnel in the esophagus and causes many complications. The thulium laser decreases the risk of bleeding and perforation in endoscopy but has not been reported in digestive diseases, especially in POEM...
January 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29342089/chitosan-gel-to-treat-pressure-ulcers-a-clinical-pilot-study
#2
Virginia Campani, Eliana Pagnozzi, Ilaria Mataro, Laura Mayol, Alessandra Perna, Floriana D'Urso, Antonietta Carillo, Maria Cammarota, Maria Chiara Maiuri, Giuseppe De Rosa
Chitosan is biopolymer with promising properties in wound healing. Chronic wounds represent a significant burden to both the patient and the medical system. Among chronic wounds, pressure ulcers are one of the most common types of complex wound. The efficacy and the tolerability of chitosan gel formulation, prepared into the hospital pharmacy, in the treatment of pressure ulcers of moderate severity were evaluated. The endpoint of this phase II study was the reduction of the area of the lesion by at least 20% after four weeks of treatment...
January 17, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/29342058/mri-evaluation-of-repaired-versus-unrepaired-interportal-capsulotomy-in-simultaneous-bilateral-hip-arthroscopy-a-double-blind-randomized-controlled-trial
#3
Colin D Strickland, Matthew J Kraeutler, Matthew J Brick, Tigran Garabekyan, Jason T K Woon, Vivek Chadayammuri, Omer Mei-Dan
BACKGROUND: Techniques used in hip arthroscopy continue to evolve, and controversy surrounds the need for capsular repair following this surgical intervention. The purpose of this study was to evaluate the magnetic resonance imaging (MRI) appearance of the hip capsule in patients with femoroacetabular impingement (FAI) who underwent simultaneous bilateral hip arthroscopy through an interportal capsulotomy with each hip randomized to undergo capsular repair or not undergo such a repair...
January 17, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29341595/self-healing-hydrogels-of-low-molecular-weight-poly-vinyl-alcohol-assembled-by-host-guest-recognition
#4
Yong-Guang Jia, Jiahong Jin, Sa Liu, Li Ren, Juntao Luo, X X Zhu
Poly(vinyl alcohol) (PVA) is a cytocompatible synthetic polymer and has been commonly used to prepare hydrogels. Bile acids and β-cyclodextrin are both natural compounds and they form stable host-guest inclusion complexes. They are attached covalently onto a low molecular weight PVA separately. Self-healing hydrogels can be easily formed by mixing the aqueous solutions of these PVA based polymers. The mechanical properties of the hydrogels can be tuned by varying the molar fractions of bile acid units on PVA...
January 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29341426/biomechanical-histological-and-computed-x-ray-tomographic-analyses-of-hydroxyapatite-coated-peek-implants-in-an-extended-healing-model-in-rabbit
#5
Pär Johansson, Sargon Barkarmo, Mohammed Hawthan, Niccolò Peruzzi, Per Kjellin, Ann Wennerberg
No abstract text is available yet for this article.
January 17, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29341335/osteogenic-efficacy-of-bmp-2-mixed-with-hydrogel-and-bone-substitute-in-peri-implant-dehiscence-defects-in-dogs-16%C3%A2-weeks-of-healing
#6
Jae-Kook Cha, Ui-Won Jung, Daniel S Thoma, Christoph H F Hämmerle, Ronald E Jung
OBJECTIVES: The objective of this study was to determine the effect of bone morphogenetic protein-2 (BMP-2) mixed with either polyethylene glycol hydrogel or synthetic bone substitute (SBS) on new bone formation in peri-implant dehiscence defects after 16 weeks of healing. MATERIALS AND METHODS: A guided bone regeneration procedure was performed in box-type peri-implant defects that were surgically prepared in six beagle dogs. The following four experimental groups were used (i) control (no graft), (ii) SBS+hydrogel, (iii) SBS+BMP-2/hydrogel and (iv) BMP-2/SBS+hydrogel...
January 17, 2018: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29341108/characteristics-of-tendon-derived-stem-cells-according-to-different-factors-to-induce-the-tendinopathy
#7
Sun Jeong Kim, Da-Hyun Song, Sang Jun Kim
Tendon derived stem cells (TDSCs) have been used as a therapeutic agent and as a healing marker. However, there has been no study about the characteristics of TDSCs extracted from tendinopathic tendon tissues. The aim of this study was to find the different characteristics of TDSCs according to the factors to induce the tendinopathy. Five- and 15-week old Sprague Dawley rats were used for this study and chemically-induced and injury-induced tendinopathy models were made depending on the age of the animal for different types of tendinopathy...
January 17, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29341038/-the-use-of-deep-inferior-epigastric-vessels-to-revascularise-free-flaps-for-reconstruction-of-complex-oncosurgical-defects-of-the-thigh-and-the-abdomen
#8
F Simunovic, U Wittel, B Passlick, S Wiesemann, M Czerny, M Südkamp, G B Stark, H Bannasch
BACKGROUND: The resection of large soft-tissue sarcoma requires reconstruction with free flaps. The choice of recipient vessels is crucial for the success of surgery. PATIENTS: We report four cases with large soft-tissue sarcomas with complex anatomical relationships: two tumors of the thigh surrounding the femoral neurovascular structures and two tumors of the abdomen with infiltration of the thorax and the abdomen. All cases received multimodal interdisciplinary treatment...
January 16, 2018: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29340954/the-cultural-epigenesis-of-gender-based-violence-in-cambodia-local-and-buddhist-perspectives
#9
Maurice Eisenbruch
Almost one in four women in Cambodia is a victim of physical, emotional or sexual violence. The study aims to provide a comprehensive understanding of the ways in which Cambodians see its causes and effects and to identify and analyse the cultural forces that underpin and shape its landscape. An ethnographic study was carried out with 102 perpetrators and survivors of emotional, physical and sexual violence against women and 228 key informants from the Buddhist and healing sectors. Their views and experiences of it were recorded-the popular idioms expressed and the symptoms of distress experienced by survivors and perpetrators...
January 16, 2018: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29340822/a-preclinical-animal-study-of-a-novel-simple-and-secure-duct-and-vessel-occluder-for-laparoscopic-surgery
#10
Amir Szold, Arnold Miller, Nir Lilach, Ana-Maria Botero-Anug, Raanan Miller, Steven D Schwaitzberg
BACKGROUND: Secure occlusion of large blood vessels and ductal structures is critical to all surgeries and remains a challenge in many minimally invasive procedures. This study compares in vivo use of the Amsel Occluder (AO) for secure laparoscopic blood vessel and duct closure, with one of the many commercially available hemoclips (Ligaclip®), in the porcine model. METHODS: Laparoscopic closure of vessels and ducts was performed on 12 swine to compare the ease of use, safety and efficacy of the AO with a hemoclip, as well as the tissue response at > 30 days (10 swine)...
January 16, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29340596/commentary-on-effect-of-botulinum-toxin-a-on-muscle-healing-and-its-implications-in-aesthetic-and-reconstructive-surgery
#11
Allen Gabriel, G Patrick Maxwell
No abstract text is available yet for this article.
January 11, 2018: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29340544/interesfincterial-ligation-of-fistula-tract-lift-for-patients-with-anal-fistulas-a-brazilian-bi-institutional-experience
#12
Sérgio Eduardo Alonso Araújo, Marcelli Tainah Marcante, Carlos Ramon Siveira Mendes, Alexandre Bruno Bertoncini, Victor Edmond Seid, Lucas Araujo Horcel, Rodrigo Oliva Perez, Sidney Klajner
BACKGROUND: The best treatment for anal fistula should extirpate infection and promote healing of the tract, whilst preserving the anal sphincter complex and full continence. AIM: To analyze the success rate after a modified technique for ligation of the intersphincteric fistula tract (LIFT) for patients with anal fistulas. METHODS: A prospective (observational cohort study) Brazilian bi-institutional experience with a modified (ligation of the intersphincteric fistula tract without excision) LIFT technique was undertaken...
October 2017: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/29340510/-tradition-improvisation-and-modernity-in-yucatecan-mayan-shamanism-the-suhuy-art-of-juan-cob-h-men-of-yaxcab%C3%A3
#13
Michel Boccara
Through the history of a Yucatecan Mayan shaman (h-men), this article analyzes the changes and continuities in Yucatecan shamanism and, more specifically, in one of its main functions: tsak, healing. The results presented here are part of fieldwork carried out over 40 years, from 1976 to 2016. The author lives in a community in central Yucatán (Tabi, Sotuta) and has carried out a number of research studies on Yucatecan shamanism in communities in the Mexican states of Yucatán, Campeche and Quintana Roo. Juan Cob, h-men of Yaxcabá, is not only an informant but also the author's friend and neighbor, with whom he has created a number of films...
July 2017: Salud Colectiva
https://www.readbyqxmd.com/read/29340480/bone-repair-access-of-boneceramic%C3%A2-in-5-mm-defects-study-on-rat-calvaria
#14
André Luis da Silva Fabris, Leonardo Perez Faverani, Pedro Henrique Silva Gomes-Ferreira, Tárik Ocon Braga Polo, Joel Ferreira Santiago-Júnior, Roberta Okamoto
OBJECTIVE: The aim of this study was to evaluate the osteoconductive potential of BoneCeramic™ on bone healing in rat calvaria 5-mm defects. MATERIAL AND METHODS: A 5-mm calvaria bone defect was induced in three groups and the defect was not filled with biomaterial [Clot Group (CG)], autogenous bone (AG), or Bone Ceramic Group (BCG). Animals were euthanized after 14 or 28 days and the bone tissue within the central area of the bone defect was evaluated. Results were compared using ANOVA and Tukey test (p<0...
January 15, 2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29340352/bone-healing-at-functionally-loaded-and-unloaded-screw-shaped-implants-supporting-single-crowns-a-histomorphometric-study-in-humans
#15
Daichi Yonezawa, Adriano Piattelli, Riccardo Favero, Mauro Ferri, Giovanna Iezzi, Daniele Botticelli
PURPOSE: To evaluate histologically and histomorphometrically the effect of a delayed load on healing at implants with a moderately rough surface. MATERIALS AND METHODS: Two solid titanium screw-shaped devices, 5 mm long and 3.5 mm in diameter, were inserted in the distal segments of the alveolar ridge of 16 volunteer patients in a nonsubmerged fashion. After 2 months, one implant was loaded, while the other was left unloaded. After 2 months, the two implants were collected from 10 patients using a sonic instrument, and ground sections were prepared from the biopsy specimens...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29340351/effect-of-low-level-laser-on-the-healing-of-bone-defects-filled-with-autogenous-bone-or-bioactive-glass-in-vivo-study
#16
Guilherme Santos Moreira, Patrick Henry Machado Alves, Luis Augusto Esper, Michyele Cristhiane Sbrana, Gisele da Silva Dalben, Karin Hermana Neppelenbroek, Ana Lúcia Pompéia Fraga de Almeida
PURPOSE: This study evaluated the effect of low-level laser therapy (LLLT) on the healing of bone defects filled with autogenous bone or bioactive glass. MATERIALS AND METHODS: A critical size defect with 5-mm diameter was created on the calvaria of 60 adult male rats divided into 6 groups (n = 10): group C (control), group LLLT (LLLT - GaAlAs, wavelength of 780 nm, power of 100 mW, energy density of 210 J/cm2 per point during 60 seconds/point, in five points, only once, after creation of the surgical defect), group AB (autogenous bone), group AB+LLLT (autogenous bone + LLLT), group BG (bioactive glass), group BG+LLLT (bioactive glass + LLLT)...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29340130/mechanism-action-of-platelets-and-crucial-blood-coagulation-pathways-in-hemostasis
#17
REVIEW
Mercy Halleluyah Periayah, Ahmad Sukari Halim, Arman Zaharil Mat Saad
Blood is considered to be precious because it is the basic necessity for health; our body needs a steady provision of oxygen, supplied via blood, to reach billions of tissues and cells. Hematopoiesis is the process that generates blood cells of all lineages. However, platelets are the smallest blood component produced from the very large bone marrow cells called megakaryocytes and they play a fundamental role in thrombosis and hemostasis. Platelets contribute their hemostatic capacity via adhesion, activation and aggregation, which are triggered upon tissue injury, and these actions stimulate the coagulation factors and other mediators to achieve hemostasis...
October 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/29340060/assessment-of-antimicrobial-and-wound-healing-effects-of-brevinin-2ta-against-the-bacterium-klebsiella-pneumoniae-in-dermally-wounded-rats
#18
Siqin Liu, Qilin Long, Yang Xu, Jun Wang, Zhongwei Xu, Lei Wang, Mei Zhou, Yuxin Wu, Tianbao Chen, Chris Shaw
Antimicrobial peptides (AMPs) are regarded as promising alternatives for antibiotics due to their inherent capacity to prevent microbial drug resistance. Amphibians are rich source of bioactive molecules, which provide numerous AMPs with various structures as drug candidates. Here, we isolated and identified a novel AMP Brevinin-2Ta (B-2Ta) from the skin secretion of the European frog, Pelophylax kl. esculentus. In vitro studies revealed that it showed broad antimicrobial activities against S. aureus, E. coli and C...
December 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29339925/mir-136-targets-mien1-and-involves-the-metastasis-of-colon-cancer-by-suppressing-epithelial-to-mesenchymal-transition
#19
Haipeng Ren, Yuanling Qi, Xiaoyan Yin, Jianfeng Gao
MIEN1 is a novel oncogene, and it involves tumor progression in various cancer types, including colon cancer. However, the definite molecular mechanisms of MIEN1 in colon cancer progression remain to be completely elucidated. In the present study, bioinformatics prediction showed that miR-136 could be an upstream regulator of MIEN1; a luciferase assay and Western blot assay revealed that miR-136 negatively regulates MIEN1 expression via directly targeting its 3'-untranslated region sequence. Moreover, a functional assay using wound healing and transwell invasion showed that overexpressed miR-136 inhibited cell migration and invasion, and overexpression of MIEN1 partly rescued the above-mentioned effects of miR-136 in colon cancer cells...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29339732/glyburide-and-retinoic-acid-synergize-to-promote-wound-healing-by-anti-inflammation-and-rip140-degradation
#20
Yi-Wei Lin, Pu-Ste Liu, Kasey Ah Pook, Li-Na Wei
Chronic inflammation underlies the development of metabolic diseases and individuals with metabolic disease often also suffer from delayed wound healing due to prolonged inflammation. Resolving inflammation provides a therapeutic strategy in treating metabolic diseases. We previously showed that during an anti-inflammatory response when macrophages were alternatively (M2) polarized, retinoic acid (RA) dramatically activated arginase 1 gene (Arg1), a gene crucial for wound healing. Here we report that a widely used sulfonylurea drug for type 2 diabetes mellitus (T2DM), glyburide, enhances the anti-inflammatory response and synergizes with RA to promote wound healing...
January 16, 2018: Scientific Reports
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