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https://www.readbyqxmd.com/read/29793113/assessment-of-the-risk-of-antiangiogenic-agents-before-and-after-surgery
#1
REVIEW
Christina E Bailey, Alexander A Parikh
Angiogenesis plays a critical role in the growth, progression, and metastasis of numerous solid tumor types, and thus, antiangiogenic agents have been studied for many years as potential therapeutic agents. Many different antiangiogenic agents, including monoclonal antibodies and multi-targeted tyrosine kinase inhibitors (TKIs), have been approved for various oncology indications, and promising clinical activity has been demonstrated. However, some of these agents have also been associated with serious safety concerns...
May 8, 2018: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/29793112/3d-printed-membrane-as-an-alternative-to-amniotic-membrane-for-ocular-surface-conjunctival-defect-reconstruction-an-in-vitro-in-vivo-study
#2
Shima Dehghani, Morteza Rasoulianboroujeni, Hamed Ghasemi, Saeed Heidari Keshel, Zohreh Nozarian, Mohammad Naser Hashemian, Mehran Zarei-Ghanavati, Golshan Latifi, Reza Ghaffari, Zhanfeng Cui, Hua Ye, Lobat Tayebi
BACKGROUND: The aim of this study was to evaluate the surgical handling and clinical applicability of a specific 3D-printed membrane design fabricated using a gelatin, elastin and sodium hyaluronate blend for conjunctival reconstruction and compare it with amniotic membrane (AM), which is normally used in such surgeries. METHODS: 3D printing technique was employed to fabricate the membrane based on gradient design. Prior to printing, rheometry was employed to optimize the ink composition...
May 11, 2018: Biomaterials
https://www.readbyqxmd.com/read/29792837/total-avulsed-ear-management-with-radial-forearm-free-flap
#3
Uzair Luqman, Zahid Qayyum, Zahid Furqan, Kaleem Ullah
Avulsive injuries to the ear are extremely challenging to treat. The literature documents numerous ways to manage such injuries. This report describes a case of total auricular cartilaginous avulsion that occurred during a motor vehicle accident. The avulsed segment had an ischemia time longer than 8 hours by the time of presentation at the authors' tertiary care facility. The avulsed segment was de-epithelialized and embedded into the volar forearm. After a healing period of 6 months, a radial forearm free flap was harvested and the ear was reconstructed...
April 28, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29792717/postoperative-monitoring-of-colorectal-anastomosis-experimental-study
#4
J Kalvach, O Ryska, J Pazin, J Hadac, S Juhas, J Juhásová, J Martínek, M Ryska
INTRODUCTION: Inadequate blood supply is one of the major risk factors for colorectal anastomotic leak. Early postoperative detection of local ischemic changes can predict complicated healing and lead to better outcome. Microdialysis (MD) offers real-time evaluation of adequate bowel perfusion through monitoring of tissue metabolism. The aim of this study was to assess the feasibility of MD for early detection of ischemic changes in colorectal anastomosis. METHOD: Five pigs with end-to-end colorectal anastomosis were included...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29792166/the-pdgfr%C3%AE-erk1-2-pathway-regulates-cdcp1-expression-in-triple-negative-breast-cancer
#5
Luca Forte, Federica Turdo, Cristina Ghirelli, Piera Aiello, Patrizia Casalini, Marilena Valeria Iorio, Elvira D'Ippolito, Patrizia Gasparini, Roberto Agresti, Beatrice Belmonte, Gabriella Sozzi, Lucia Sfondrini, Elda Tagliabue, Manuela Campiglio, Francesca Bianchi
BACKGROUND: CDCP1, a transmembrane protein with tumor pro-metastatic activity, was recently identified as a prognostic marker in TNBC, the most aggressive breast cancer subtype still lacking an effective molecular targeted therapy. The mechanisms driving CDCP1 over-expression are not fully understood, although several stimuli derived from tumor microenvironment, such as factors present in Wound Healing Fluids (WHFs), reportedly increase CDCP1 levels. METHODS: The expression of CDCP1, PDGFRβ and ERK1/2cell was tested by Western blot after stimulation of MDA-MB-231 cells with PDGF-BB and, similarly, in presence or not of ERK1/2 inhibitor in a panel of TNBC cell lines...
May 23, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29791931/effectiveness-of-a-crocus-sativus-extract-on-burn-wounds-in-rats
#6
Esmat Alemzadeh, Ahmad Oryan
Crocus sativus is a spice with various pharmacological properties. Crocin, picrocrocin, and safranal are the main compositions of saffron that have recently been considered in the therapy of many diseases. High-performance liquid chromatography analysis revealed presence of these compounds in our saffron extract. This study was carried out to evaluate the effect of saffron on burn wound healing at an in vivo model. Saffron was topically applied on burn wounds in rats; the percentage of wound closure, wound contraction, and the levels of main cytokines and growth factors were measured...
May 23, 2018: Planta Medica
https://www.readbyqxmd.com/read/29791926/meniscus-repair-in-children-and-adolescents-a-systematic-review-of-treatment-approaches-meniscal-healing-and-outcomes
#7
Márcio Balbinotti Ferrari, Colin P Murphy, João Luiz Ellera Gomes
Although the consequences of traumatic meniscus tears and the importance of meniscal repair are well-established in adults, the same cannot be said for the young population. Better evidence regarding the outcomes following traumatic meniscal tears in children would improve our understanding of this increasing pathology and help define important factors in deciding the best treatment option. A systematic review was performed according to the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines using the Cochrane Database of Systematic Review, Cochrane Central Register of Controlled Trials, MEDLINE Ovid, and MEDLINE PubMed databases...
May 23, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29791784/chitosan-hydrogels-and-bionanocomposites-formed-through-the-mineralization-and-regulated-charging
#8
REVIEW
Irina Postnova, Vladimir Silant'ev, Sergei Sarin, Yury Shchipunov
The account presents survey of our systematic studies on chitosan. Only this polysaccharide bears cationic charges, possesses antimicrobial activity and wound healing ability that make it highly appropriate for using in medicine, biomedical engineering, cosmetics, food, packaging. However, its application meets with severe limitation. Chitosan belongs to polysaccharides that do not jellify solutions. Main approaches are based on the chemical modifications and cross-linking, but these treatments impairs therewith the biocompatibility and biological activity of chitosan...
May 23, 2018: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29791703/biological-intercalary-reconstruction-with-bone-grafts-after-joint-sparing-resection-of-the-lower-limb-is-this-an-effective-and-durable-solution-for-joint-preservation
#9
Francesco Muratori, Francesca Totti, Antonio D'Arienzo, Maurizio Scorianz, Guido Scoccianti, Giovanni Beltrami, Francesco Rosario Campo, Carmine Citarelli, Rodolfo Capanna, Domenico Andrea Campanacci
Due to advances in neoadjuvant therapies and preoperative imaging modalities, joint-sparing resections have become appealing in bone tumor surgery. However, the intercalary reconstruction of metadiaphyseal bone defects of the femur and the tibia after juxta-articular tumor resection remains challenging. Both biological and prosthetic reconstructions have been used for joint-sparing resections, but little is known about the long-term outcome of these procedures. The authors reviewed a consecutive series of 64 patients treated with joint-sparing intercalary resection and reconstruction with bone grafts...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791700/closing-the-gap-novel-abdominal-wound-closure-techniques
#10
James Dana Kondrup, Alaina M Qayyum
Traditionally, surgical procedures within the realm of both general and gynecological surgery employ the use of staples and interrupted sutures that run continuously with knot tying or subcuticular sutures to ensure closure of large wound incisions, subcuticular incisions, and fascial repair. However, these methods may not always be cosmetically favorable and, thus, result in an unpleasant outcome for the patient, adding to their surgery-related stress. It is, therefore, imperative that surgeons and gynecologists are aware of alternative methods of wound closure that are not only cosmetically favorable, but also ensure rapid wound recovery and infection control...
June 1, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29791570/osteoradionecrosis-of-the-jaws-case-series-treated-with-adjuvant-low-level-laser-therapy-and-antimicrobial-photodynamic-therapy
#11
Guilherme Henrique Ribeiro, Mariana Comparotto Minamisako, Inês Beatriz da Silva Rath, Aira Maria Bonfim Santos, Alyne Simões, Keila Cristina Rausch Pereira, Liliane Janete Grando
BACKGROUND: Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29791314/analgesic-anti-inflammatory-and-anti-arthritic-properties-of-aqueous-and-methanolic-stem-bark-extracts-from-nauclea-pobeguinii-rubiacee-in-rats
#12
Mbiantcha Marius, Tsafack Eric Gonzal, Ateufack Gilbert, Nana Yousseu William, Bomba Tatsinkou Francis Désiré, Djuichou Nguemnang Stephanie Flore, Mbankou Ngassam Sorelle, Wego Kamgaing Marius Tresor
Background Nauclea pobeguinii is a plant species found in the centre region of Cameroon. The stem bark of this plant is traditionally used to ease pain and cure inflammation. Method This study was undertaken to evaluate the effects of doses 150 and 300 mg/kg of the aqueous and methanolic stem bark extracts from Nauclea pobeguinii on acute pain, acute and chronic inflammation induced by formalin and arthritis induced by zymosan A in rats. Oxidative stress parameters such as catalase, malondialdehyde and nitric oxide were measured in rats subjected to chronic inflammation...
May 23, 2018: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29791009/withdrawn-interventions-for-replacing-missing-teeth-1-versus-2-stage-implant-placement
#13
REVIEW
Marco Esposito, Maria Gabriella Grusovin, Yun Shane Chew, Paul Coulthard, Helen V Worthington
BACKGROUND: Implants may be placed penetrating the oral mucosa (1-stage procedure) or can be completely buried under the oral mucosa (2-stage procedure) during the healing phase of the bone at the implant surface. With a 2-stage procedure the risk of having unwanted loading onto the implants is minimized, but a second minor surgical intervention is needed to connect the healing abutments and more time is needed prior to start the prosthetic phase because of the wound-healing period required in relation to the second surgical intervention...
May 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29790898/ezh2-induces-the-expression-of-mir-1301-as-a-negative-feedback-control-mechanism-in-triple-negative-breast-cancer
#14
Qiuju Wu, Zekun Chen, Guihua Zhang, Wenhui Zhou, You Peng, Rong Liu, Ceshi Chen, Jing Feng
Breast cancer is one of the most common malignancies in women. ERα, PR, and HER2 triple negative breast cancer (TNBC) is the current research focus because of the lack of effective targeted therapies. In our study, lentivirus systems were used to overexpress EZH2 and miR-1301 in TNBC cell lines. Western blot analysis and RT-qPCR were used to detect the protein and microRNA levels. The TCGA and Kaplan Meier plotter databases were used to analyze the EZH2 and miR-1301 expression levels in breast cancer. The effect of miR-1301 overexpression on cell proliferation, migration and colony formation were determined by using the sulforhodamine B (SRB) assay, wound healing assay and colony formation assay, respectively...
May 22, 2018: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29790728/hydroxylated-polybrominated-biphenyl-ethers-exert-estrogenic-effects-via-non-genomic-g-protein-coupled-estrogen-receptor-mediated-pathways
#15
Lin-Ying Cao, Xiao-Min Ren, Yu Yang, Bin Wan, Liang-Hong Guo, De Chen, Yong Fan
BACKGROUND: Numerous studies have indicated the estrogenic effects of polybrominated diphenyl ethers (PBDEs) and hydroxylated PBDEs (OH-PBDEs). However, the previous mechanistic studies focused on their estrogenic effects through genomic transcriptional activation of estrogen receptors. OBJECTIVE: The present study aimed to investigate the estrogenic effects of PBDEs and OH-PBDEs via nongenomic G protein-coupled estrogen receptor (GPER) pathways. METHODS: The binding affinities of 12 PBDEs and 18 OH-PBDEs with GPER were determined by a fluorescence competitive binding assay in a human breast cancer cell line (SKBR3)...
May 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29790567/regional-diversity-in-the-murine-cortical-vascular-network-is-revealed-by-synchrotron-x-ray-tomography-and-is-amplified-with-age
#16
J A Núñez, A Goring, B Javaheri, H Razi, D Gomez-Nicola, A A Pitsillides, P J Thurner, D Gomez-Nicola, P Schneider, C E Clarkin
TCortical bone is permeated by a system of pores, occupied by the blood supply and osteocytes. With ageing, bone mass reduction and disruption of the microstructure are associated with reduced vascular supply. Insight into the regulation of the blood supply to the bone could enhance the understanding of bone strength determinants and fracture healing. Using synchrotron radiation-based computed tomography, the distribution of vascular canals and osteocyte lacunae was assessed in murine cortical bone and the influence of age on these parameters was investigated...
May 23, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29790327/-the-effective-educational-interventions-in-the-promotion-of-self-care-in-people-with-heart-failure-a-literature-review
#17
REVIEW
Sara Alberti, Silvia Rossini
INTRODUCTION: Self-care in people with heart failure is subject of recent middle-range and short-range nursing theories and its promotion is recognized as a sensitive nursing outcome, achievable through various strategies including education. PURPOSE: To identify educational interventions that are effective in the promotion of self-care in adults and elderly people with heart failure, evaluating educational methods and tools used and their effectiveness in the medium-long term period...
January 2018: Professioni Infermieristiche
https://www.readbyqxmd.com/read/29790316/chronic-non-healing-ulcer-of-the-oral-cavity-tuberculosis-or-carcinoma
#18
Neeti Swarup, Meghanand T Nayak, Nitali Arun, S Chandarani, Zoya Chowdhary
Tuberculosis is a chronic granulomatous lesion, which primarily has an affinity for the lungs. It can involve other sites like lymph nodes, kidney, oral cavity. Infection of the oral cavity by M. tuberculosis can be as a Primary infection or as a Secondary infection. Primary presentation of oral tuberculosis is in the form of the chronic non healing ulcer. A Primary infection or an Asymptomatic Secondary infection can impose a great diagnostic dilemma, as it may mimic neoplasia. Here we present a case of a 32-year-old asymptomatic female with secondary infection...
May 2018: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29790257/functionalized-silk-fibers-from-transgenic-silkworms-for-wound-healing-applications-surface-presentation-of-bioactive-epidermal-growth-factor
#19
Michael Wöltje, Melanie Böbel, Michaela Bienert, Sabine Neuss, Dilibaier Aibibu, Chokri Cherif
Growth factors play a crucial role in wound healing in general and are promising tools for the treatment of chronic wounds as they can restore the physiological wound healing process. In growth factor-loaded wound dressings, human epidermal growth factor (EGF) is released in a burst and washed out quickly. The developed matrix consists of recombinant EGF produced in transgenic silkworms as a fusion protein with the fibroin light chain. The covalent linkage prevents EGF from draining into the surrounding tissue while presenting the growth factor on the surface...
May 23, 2018: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/29790139/-the-process-of-healing-child-physical-abuse-sprouting-and-twining
#20
Hsin-Yi Chang, Jui-Ying Feng, Ren-Mei Tseng
BACKGROUND: Child physical abuse impacts the physical and psychological health of survivors. Healing child abuse is an essential process that helps survivors reorganize the meaning of the trauma and pursue a normal life. Considering the trauma of child physical abuse within the social context allows the experiences of individual survivors to be reflected in their process of healing. PURPOSE: To explore the social interaction and construction process of healing experienced by survivors of child physical abuse...
June 2018: Hu Li za Zhi the Journal of Nursing
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