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https://www.readbyqxmd.com/read/28454465/microarray-based-analysis-of-gene-regulation-by-mesenchymal-stem-cells-in-breast-cancer
#1
Ming Zhang, Chang E Gao, Wen Hui Li, Yi Yang, Li Chang, Jian Dong, Yan Xin Ren, De Dian Chen
Breast cancer is one of the most common malignant tumors with a high case-fatality rate among women. The present study aimed to investigate the effects of mesenchymal stem cells (MSCs) on breast cancer by exploring the potential underlying molecular mechanisms. The expression profile of GSE43306, which refers to MDA-MB-231 cells with or without a 1:1 ratio of MSCs, was downloaded from Gene Expression Omnibus database for differentially expressed gene (DEG) screening. The Database for Annotation, Visualization and Integrated Discovery was used for gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for DEGs...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454463/reduced-ebp50-expression-levels-are-correlated-with-unfavorable-clinicopathological-features-of-extrahepatic-bile-duct-carcinoma-and-promote-the-proliferation-and-migration-of-qbc939-cells
#2
Duiping Feng, Ying Xiong, Zhiqiang Peng, Qiang Ma, Tao Tao, Hua Liu, Jianfang Liang, Zhigang Wei, Junfang Zheng, Lei Wang, Hui Zhang
The present study aimed to clarify the association between ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) expression level and the tumor phenotype and clinicopathological features of extrahepatic bile duct carcinoma. Tissue samples from patients with extrahepatic bile duct carcinoma (54 cases) and patients with normal bile duct epithelia from gallbladder of cholecystitis (20 cases) were collected, and immunohistochemical staining was used to detect the expression levels of EBP50 in these tissues. In addition, small interfering (si)RNA-EBP50 was used to knock down the expression of EBP50 in the QBC939 human cholangiocarcinoma (CC) cell line...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454443/mir-185-3p-regulates-the-invasion-and-metastasis-of-nasopharyngeal-carcinoma-by-targeting-wnt2b-in-vitro
#3
Chao Liu, Guo Li, Shuling Ren, Zhongwu Su, Yunyun Wang, Yongquan Tian, Yong Liu, Yuanzheng Qiu
MicroRNAs (miRs) have been recognised as important regulators of malignant behaviour in different types of human cancer, including nasopharyngeal carcinoma (NPC). A previous study by our group revealed that miR-185-3p regulates the radioresistance of NPC cells. The present study aimed to investigate the effect of miR-185-3p on NPC invasion and metastasis. Human NPC CNE-2 and 5-8F cell lines were transfected with a miR-185-3p mimic and miR-185-3p inhibitor, respectively, and their effects on the invasion and metastasis of these cells was assessed using a wound healing assay and Matrigel invasion assay...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454417/mir-185-enhances-the-inhibition-of-proliferation-and-migration-induced-by-ionizing-radiation-in-melanoma
#4
Jinpeng He, Ning Tian, Yanli Yang, Liangliang Jin, Xiu Feng, Junrui Hua, Sulan Lin, Bing Wang, He Li, Jufang Wang
Melanoma is an aggressive malignancy that is increasingly common and exhibits a poor patient survival rate. Radiotherapy is the primary option for patients with melanoma, particularly those who are not candidates for surgery; however, the therapeutic effect is limited due to the relative radioresistance of melanoma to ionizing radiation (IR). It has been reported that microRNAs (miRNAs) serve a vital role in determining the radiosensitivity of tumors; however, little is known concerning the radiosensitization of melanoma using miRNA...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454392/klf7-overexpression-in-human-oral-squamous-cell-carcinoma-promotes-migration-and-epithelial-mesenchymal-transition
#5
Xiaojun Ding, Xinhao Wang, Yiming Gong, Hong Ruan, Yang Sun, Youcheng Yu
Krüppel-like factor 7 (KLF7) is a member of the KLF family of zinc finger transcription factors, and was the first KLF cloned using complementary DNA and polymerase chain reaction (PCR) techniques with human vascular endothelial cells as a template. In addition, KLF7 is known as the ubiquitous Krüppel-like factor, as it is widely expressed in numerous human tissues at low levels. In the present study, the function of KLF7 in migration and epithelial-mesenchymal transition (EMT), which are associated with tumor progression, was investigated in human oral squamous cell carcinoma (OSCC) cells...
April 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454224/direct-targeting-of-mapk8ip1-by-mir-10a-5p-is-a-major-mechanism-for-gastric-cancer-metastasis
#6
Yaoyong Lu, Ganbao Wei, Liangbo Liu, Yichao Mo, Qingsheng Chen, Lufei Xu, Rongwei Liao, Dehao Zeng, Kunqiang Zhang
MicroRNA (miRNA) are endogenous non-coding RNAs that suppress gene expression at the transcriptional, post-transcriptional or translational level by targeting the 3'-UTRs of specific mRNAs. miR-10a has been frequently reported to be aberrantly overexpressed in human tumors. In gastric cancer (GC), miR-10a has an important role in the metastasis from primary GC to lymph nodes. However, the role and relevant pathways of miR-10a in GC metastasis remain largely unknown. The present study was performed using 41 GC and 20 normal gastric mucosa tissues...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454219/extracellular-hsp70-hsp70-pcs-regulate-hepatocarcinoma-cell-migration-and-invasion-via-rhoa
#7
Zhe Yi, Yan Li, Dan Liu, Jingang Liu, Hangyu Li
The effects of heat shock protein 70 (HSP70)/HSP70-peptide complexes (HSP70-PCs) on the invasion and metastasis ability of hepatocellular carcinoma (HCC) Huh-7 cells were investigated. Wound healing assay revealed that cells treated with HSP70/HSP70-PCs healed faster than negative control cells. HSP70/HSP70-PCs-treated cells also exhibited better migration ability and higher invasion ability than control cells. HSP70/HSP70-PCs treatment did not alter the messenger RNA (mRNA) or protein levels of matrix metalloproteinase-9; the opposite was true for Ras homolog family member A (RhoA) mRNA and protein levels...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453951/are-biodegradable-plates-applicable-in-endoscope-assisted-open-reduction-and-internal-fixation-of-mandibular-subcondyle-fractures
#8
Jang-Ho Son, Jinhee Ha, Yeong-Cheol Cho, Iel-Yong Sung
PURPOSE: To investigate whether biodegradable plates are applicable in endoscope-assisted open reduction and internal fixation (EAORIF) of mandibular subcondyle fractures. MATERIALS AND METHODS: This retrospective case-series study included patients with mandibular subcondyle fractures treated with EAORIF using an unsintered hydroxyapatite particles/poly-l-lactide biodegradable plate system, with at least 6 months of clinical follow-up data available. The outcome variables were fracture healing with postoperative stability and postoperative complications...
April 4, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28453878/titanium-implant-functionalization-with-phosphate-containing-polymers-may-favor-in-vivo-osseointegration
#9
Marcio V Cardoso, Judith de Rycker, Amol Chaudhari, Eduardo Coutinho, Yasuhiro Yoshida, Bart Van Meerbeek, Marcelo F Mesquita, Wander J da Silva, Kumiko Yoshihara, Katleen Vandamme, Joke Duyck
AIM: Osseointegration of titanium implants is predictable, but can be improved via surface functionalization. MATERIALS AND METHODS: 120 implants were installed in parietal bone of 12 domestic pigs and left to heal for 1 or 3 months. Five groups were defined according surface treatments: immersion in water (H2O), 10% polyphosphoric acid (PPA10), 1% phosphorylated pullulan (PPL1), 10% phosphorylated pullulan (PPL10), or 10% phosphorylated pullulan + 1 μg BMP-2 (PPL10 BMP)...
April 28, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28453766/comparable-immune-function-inhibition-by-the-infliximab-biosimilar-ct-p13-implications-for-treatment-of-inflammatory-bowel-disease
#10
Ki Jung Lim, So Jung Lee, Sunghwan Kim, Su Yeon Lee, Min Seob Lee, Yoon A Park, Eun Jin Choi, Eun Beom Lee, Hwang Keun Jun, Jong Moon Cho, SooYoung Lee, Ki Sung Kwon, Byung Pil Lim, Myung-Shin Jeon, Eui Cheol Shin, Yong Sung Choi, Ella Fudim, Orit Picard, Miri Yavzori, Shomron Ben-Horin, Shin Jae Chang
Background and Aims: CT-P13 is the first biosimilar monoclonal antibody to infliximab, and was recently approved in the European Union, Japan, Korea, and USA for all six indications of infliximab. However, studies directly assessing the biologic activity of CT-P13 versus inflximab in the context of inflammatory bowel disease [IBD] are still scanty. In the present study, we aimed to compare the biological activities of CT-P13 and infliximab with specific focus on intestinal cells so as to gain insight into the potential biosimilarity of these two agents for treatment of IBD...
May 1, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/28453556/characterization-of-interfragmentary-motion-associated-with-common-osteosynthesis-devices-for-rat-fracture-healing-studies
#11
Nicholaus Meyers, Matthias Sukopp, Rudolf Jäger, Malte Steiner, Romano Matthys, Bernd Lapatki, Anita Ignatius, Lutz Claes
Rat models are widely used in preclinical studies investigating fracture healing. The interfragmentary movement at a fracture site is critical to the course of healing and therefore demands definition in order to aptly interpret the experimental results. Estimation of this movement requires knowledge of the fixation stiffness and loading. The characteristic loading for the rat femur has been estimated, but the stiffness of fixation used in rat studies has yet to be fully described. This study aimed to determine the 6 degree of freedom stiffness of four commonly used implants, two external fixators (RatExFix and UlmExFix), a locking plate, and a locking intramedullary nail, in all degrees of freedom and estimate the interfragmentary movement under specific physiological loads...
2017: PloS One
https://www.readbyqxmd.com/read/28453348/the-effect-of-therapeutic-whirlpool-and-hot-packs-on-hand-volume-during-rehabilitation-after-distal-radius-fracture-a-blinded-randomized-controlled-trial
#12
Mike Szekeres, Joy C MacDermid, Trevor Birmingham, Ruby Grewal, Emily Lalone
BACKGROUND: Edema is a possibility with all heating modalities due to the increase in local blood flow caused by vasodilation. Despite the frequent application of superficial heat modalities, their relative effect on hand volume has not been determined for the upper extremity. The objective of this study was to compare the immediate effects of hot packs and whirlpool on hand volume for patients with distal radius fracture (DRF) and to determine whether any changes in volume between these modalities were still present 30 minutes after heat application...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28453341/the-scaphoid-staple-a-systematic-review
#13
John Dunn, Nicholas Kusnezov, Austin Fares, Justin Mitchell, Miguel Pirela-Cruz
BACKGROUND: The purpose of this systematic review is to analyze the indications, outcomes, and complications of scaphoid fixation with a staple. METHODS: The literature was reviewed for all cases of the scaphoid staple. Five articles including 188 patients, of 77 primary scaphoid fractures and 111 other indications that included delayed union, nonunion, and avascular necrosis, were reviewed. Demographic data, outcomes, and complications were recorded. RESULTS: The union rate of the scaphoid staple is 94...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28453295/postinjury-exercise-and-platelet-rich-plasma-therapies-improve-skeletal-muscle-healing-in-rats-but-are-not-synergistic-when-combined
#14
Paola Contreras-Muñoz, Joan Ramon Torrella, Xavier Serres, David Rizo-Roca, Meritxell De la Varga, Ginés Viscor, Vicente Martínez-Ibáñez, José Luis Peiró, Tero A H Järvinen, Gil Rodas, Mario Marotta
BACKGROUND: Skeletal muscle injuries are the most common sports-related injury and a major concern in sports medicine. The effect of platelet-rich plasma (PRP) injections on muscle healing is still poorly understood, and current data are inconclusive. PURPOSE: To evaluate the effects of an ultrasound-guided intramuscular PRP injection, administered 24 hours after injury, and/or posttraumatic daily exercise training for 2 weeks on skeletal muscle healing in a recently established rat model of skeletal muscle injury that highly mimics the muscle trauma seen in human athletes...
April 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28449508/avoiding-completion-pneumonectomy-by-omentopexy-for-bronchial-dehiscence
#15
Takuro Miyazaki, Naoya Yamasaki, Tomoshi Tsuchiya, Keitaro Matsumoto, Ryotaro Kamohara, Go Hatachi, Shigekazu Hidaka, Takeshi Nagayasu
A 56-year-old man underwent right upper sleeve lobectomy with mediastinal lymph node dissection after induction chemoradiotherapy (CRT) for advanced non-small cell lung cancer (NSCLC). The patient developed anastomotic dehiscence 11 days postoperatively. A fistula measuring 10 mm in diameter was found around the transition region between cartilage and membranous portions of the bronchus. To avoid completion right pneumonectomy, omentopexy was performed to cover the bronchial dehiscence and facilitate healing...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28449330/exploring-the-experience-of-nurse-practitioners-who-have-committed-medical-errors-a-phenomenological-approach
#16
Romuald Delacroix
BACKGROUND AND PURPOSE: To explore the experience of committing medical error from the perspective of nurse practitioners (NPs). Overall, the purpose of the study is to discern NPs' behaviors, perceptions, and coping mechanisms in response to having made a medical error. METHODS: Qualitative research based on two face-to-face audio-recorded semistructured interviews with 10 NPs who had made medical errors in practice. The analysis was guided by concepts in phenomenology...
April 27, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28449283/physiological-responses-of-reared-sea-bream-sparus-aurata-linnaeus-1758-to-an-amyloodinium-ocellatum-outbreak
#17
M Moreira, D Schrama, F Soares, T Wulff, P Pousão-Ferreira, P Rodrigues
Amyloodiniosis represents a major bottleneck for semi-intensive aquaculture production in Southern Europe, causing extremely high mortalities. Amyloodinium ocellatum is a parasitic dinoflagellate that can infest almost all fish, crustacean and bivalves that live within its ecological range. Fish mortalities are usually attributed to anoxia, associated with serious gill hyperplasia, inflammation, haemorrhage and necrosis in heavy infestations; or with osmoregulatory impairment and secondary microbial infections due to severe epithelial damage in mild infestation...
April 27, 2017: Journal of Fish Diseases
https://www.readbyqxmd.com/read/28448875/bioengineered-mannan-sulphate-capped-silver-nanoparticles-for-accelerated-and-targeted-wound-healing-physicochemical-and-biological-investigations
#18
Megha Mugade, Milind Patole, Varsha Pokharkar
In the present study, surface functionalized mannan sulphate silver nanoparticles (MS-AgNPs) were prepared and assessed for their wound healing potential. 20nm sized, spherical MS-AgNPs were prepared by one pot synthesis approach wherein the sulphated polysaccharide mannan sulphate (MS) played dual role of reducing as well as capping agent. The crystalline MS-AgNPs exhibited surface plasmon resonance centered at 400nm along with -32.40mV zeta potential. These stable MS-AgNPs showed enhanced cytocompatibility, targeting potential and cellular uptake in murine macrophages, human skin fibroblasts and human keratinocytes as compared to citrate reduced silver nanoparticles (C-AgNPs)...
April 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28448860/a-unique-presentation-of-renal-cell-transformation-into-renal-cell-carcinoma-in-subcutaneous-fatty-tissue-post-twenty-year-old-healing-gun-shot-wound-a-case-report
#19
Awadh R Alqahtani, Mohammed A Alqahtani
INTRODUCTION: Renal cell carcinoma (RCC) is the most common malignancy in the genitourinary tract, and is among the 10 most common cancers in both males and females. PRESENTATION OF CASE: We report a case of a 61-year-old male who presented with a cutaneous lesion on his left back side at a site where he had undergone several surgeries - including Left nephrectomy - twenty years ago for a gun-shot wound he sustained which penetrated his abdomen. DISCUSSION: At that time pathology reports turned out to be normal, specially left kidney pathology report which was negative for any malignancy...
March 21, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28448670/molecular-mechanisms-underlying-the-filtration-bleb-maintaining-effects-of-suberoylanilide-hydroxamic-acid-saha
#20
Akiko Futakuchi, Toshihiro Inoue, Tomokazu Fujimoto, Utako Kuroda, Miyuki Inoue-Mochita, Eri Takahashi, Saori Ohira, Hidenobu Tanihara
Purpose: Suberoylanilide hydroxamic acid (SAHA) has been shown to support the maintenance of experimental filtration blebs in animal models. This study was performed to investigate the molecular mechanisms underlying the bleb-maintaining effects of SAHA in modulating wound healing activities of conjunctival fibroblasts. Methods: Human conjunctival fibroblasts (HConFs) were pretreated with SAHA before treatment with TGF-β2. Microarray-based screening was used to investigate the gene expression profiles...
April 1, 2017: Investigative Ophthalmology & Visual Science
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