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nkt cells and obesity

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https://www.readbyqxmd.com/read/27659424/glycine-prevents-metabolic-steatohepatitis-in-diabetic-kk-ay-mice-through-modulation-of-hepatic-innate-immunity
#1
Shiori Takashima, Kenichi Ikejima, Kumiko Arai, Junko Yokokawa, Kazuyoshi Kon, Shunhei Yamashina, Sumio Watanabe
Strategies for prevention and treatment of nonalcoholic steatohepatitis (NASH) remain to be established. Here, we evaluated the effect of glycine on metabolic steatohepatitis in genetically obese, diabetic KK-A(y) mice. Male KK-A(y) mice were fed a diet containing 5% glycine for 4 weeks, and liver pathology was evaluated. Hepatic mRNA levels for lipid-regulating molecules, cytokines/chemokines, and macrophage M1/M2 markers were determined by real time RT-PCR. Hepatic expression of natural killer (NK) T cells was analyzed by flow cytometry...
September 22, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27562191/il-33-driven-ilc2-eosinophil-axis-in-fat-is-induced-by-sympathetic-tone-and-suppressed-by-obesity
#2
Xiaofeng Ding, Yan Luo, Xing Zhang, Handong Zheng, Xin Yang, Xuexian Yang, Meilian Liu
Group 2 innate lymphoid cells (ILC2s) in white adipose tissue (WAT) promote WAT browning and assist in preventing the development of obesity. However, how ILC2 in adipose tissue is regulated remains largely unknown. Here, our study shows that ILC2s are present in brown adipose tissue (BAT) as well as subcutaneous and epididymal WAT (sWAT and eWAT). The fractions of ILC2s, natural killer T (NKT) cells and eosinophils in sWAT, eWAT and BAT are significantly decreased by high-fat-diet (HFD) feeding and leptin deficiency-induced obesity...
October 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27441847/a-new-mouse-model-that-spontaneously-develops-chronic-liver-inflammation-and-fibrosis
#3
Nina Fransén-Pettersson, Nadia Duarte, Julia Nilsson, Marie Lundholm, Sofia Mayans, Åsa Larefalk, Tine D Hannibal, Lisbeth Hansen, Anja Schmidt-Christensen, Fredrik Ivars, Susanna Cardell, Richard Palmqvist, Björn Rozell, Dan Holmberg
Here we characterize a new animal model that spontaneously develops chronic inflammation and fibrosis in multiple organs, the non-obese diabetic inflammation and fibrosis (N-IF) mouse. In the liver, the N-IF mouse displays inflammation and fibrosis particularly evident around portal tracts and central veins and accompanied with evidence of abnormal intrahepatic bile ducts. The extensive cellular infiltration consists mainly of macrophages, granulocytes, particularly eosinophils, and mast cells. This inflammatory syndrome is mediated by a transgenic population of natural killer T cells (NKT) induced in an immunodeficient NOD genetic background...
2016: PloS One
https://www.readbyqxmd.com/read/27329323/adipocyte-specific-cd1d-deficiency-mitigates-diet-induced-obesity-and-insulin-resistance-in-mice
#4
Masashi Satoh, Miyuki Hoshino, Koki Fujita, Misao Iizuka, Satoshi Fujii, Christopher S Clingan, Luc Van Kaer, Kazuya Iwabuchi
It has been shown that CD1d expression and glycolipid-reactive, CD1d-restricted NKT cells exacerbate the development of obesity and insulin resistance in mice. However, the relevant CD1d-expressing cells that influence the effects of NKT cells on the progression of obesity remain incompletely defined. In this study, we have demonstrated that 3T3-L1 adipocytes can present endogenous ligands to NKT cells, leading to IFN-γ production, which in turn, stimulated 3T3-L1 adipocytes to enhance expression of CD1d and CCL2, and decrease expression of adiponectin...
June 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27171408/celiac-disease-related-inflammation-is-marked-by-reduction-of-nkp44-nkp46-double-positive-natural-killer-cells
#5
Irene Marafini, Ivan Monteleone, Davide Di Fusco, Silvia Sedda, Maria Laura Cupi, Daniele Fina, Alessandro Omero Paoluzi, Francesco Pallone, Giovanni Monteleone
INTRODUCTION AND AIM: Natural killer (NK) cells are a first line of defence against viruses and down-regulation of NK cell cytotoxic receptors represents one of the strategies by which viruses escape the host's immune system. Since onset of celiac disease (CD), a gluten-driven enteropathy, has been associated with viral infections, we examined whether CD-associated inflammation is characterized by abnormal distribution of NK cell receptors involved in recognition of viral-infected cells...
2016: PloS One
https://www.readbyqxmd.com/read/27117277/infectious-siv-resides-in-adipose-tissue-and-induces-metabolic-defects-in-chronically-infected-rhesus-macaques
#6
Jacob Couturier, Neeti Agarwal, Pramod N Nehete, Wallace B Baze, Michael A Barry, K Jagannadha Sastry, Ashok Balasubramanyam, Dorothy E Lewis
BACKGROUND: HIV reservoirs pose major challenges to viral eradication. The main cellular reservoirs include CD4 T cells and macrophages, whereas anatomic reservoirs are thought to be primarily lymphoid tissues. Adipose tissue represents a potentially important non-lymphoid location for HIV replication and persistence because the stromal-vascular-fraction (AT-SVF) contains activated innate and adaptive immune cells that increase in number during infections, obesity, and chronic inflammation...
2016: Retrovirology
https://www.readbyqxmd.com/read/26993045/adiponectin-a-versatile-player-of-innate-immunity
#7
REVIEW
Yan Luo, Meilian Liu
Adiponectin acts as a key regulator of the innate immune system and plays a major role in the progression of inflammation and metabolic disorders. Macrophages and monocytes are representative components of the innate immune system, and their proliferation, plasticity, and polarization are a key component of metabolic adaption. Innate-like lymphocytes such as group 2 innate lymphoid cells (ILC2s), natural killer T (NKT) cells, and gamma delta T (γδ T) cells are also members of the innate immune system and play important roles in the development of obesity and its related diseases...
April 2016: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/26815139/maternal-obesity-associated-with-increase-in-natural-killer-t-cells-and-cd8-regulatory-t-cells-in-cord-blood-units
#8
Luis Octavio Gonzalez-Espinosa, Laura Arcelia Montiel-Cervantes, Angel Guerra-Márquez, Karina Peñaflor-Juárez, Elba Reyes-Maldonado, Jorge Vela-Ojeda
BACKGROUND: One of the major limitations of umbilical cord blood (UCB) as hematopoietic stem cell source is its restricted cell number. In mothers who are candidates for stem cell donation, there are variables that affect the quantity and quality of UCB units. The aim of this study was to determine if obstetric, maternal, and fetal factors modify the number of lymphocyte subsets in UCB units. STUDY DESIGN AND METHODS: This was a prospective, observational study...
May 2016: Transfusion
https://www.readbyqxmd.com/read/26648772/staphylococcus-enterotoxin-b-induced-t-cells-can-efficaciously-protect-against-type-1-diabetes-in-non-obese-diabetic-mice
#9
Yelei Guo, Lei Xia, Shilun Zhang, Jiang Zhong, Yu Chen
Type 1 diabetes (T1D), an autoimmune disease, can be protected against by natural killer T (NKT) cells. Several attempts demonstrate that NKT cells also can be produced by inducing with Staphylococcus enterotoxin B (SEB) in addition to its classical activated antigen α-galactosylceramide. Here, we examined a potential usage of SEB-induced T (SEB-T) cells for the treatment of T1D. We established the immunophenotypes of SEB-T cells via flow cytometry, and in consequence, enriched in CD8(+)NKT cells after SEB stimulated...
2015: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/26629029/obesity-enhances-th2-inflammatory-response-via-natural-killer-t-cells-in-a-murine-model-of-allergic-asthma
#10
Yi-Ping Chen, Jing-Hong Zhang, Chao-Qian Li, Qi-Xiang Sun, Xiao-Hong Jiang
BACKGROUND: Obesity increases the incidence of asthma, but mechanism between asthma and obesity isn't utterly understood. NKT cells are intermediary activist between the innate and adaptive immune. It may play an equally important role in both obesity and asthma. We studied an obese mouse model of allergic asthma to test whether NKT cells act as a linkage in the development of obesity with asthma. METHODS: Balb/c mice were divided into control group (A), asthma model group (B), the obesity group (C) and obesity with asthma group (D), asthma model made by OVA...
2015: International Journal of Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/26447219/nkt-cell-modulates-nafld-potentiation-of-metabolic-oxidative-stress-induced-mesangial-cell-activation-and-proximal-tubular-toxicity
#11
Firas Alhasson, Diptadip Dattaroy, Suvarthi Das, Varun Chandrashekaran, Ratanesh Kumar Seth, Rick G Schnellmann, Saurabh Chatterjee
Obesity and nonalcoholic fatty liver disease (NAFLD) are associated with the development and progression of chronic kidney disease. We recently showed that NAFLD induces liver-specific cytochrome P-450 (CYP)2E1-mediated metabolic oxidative stress after administration of the CYP2E1 substrate bromodichloromethane (BDCM) (Seth RK, Das S, Kumar A, Chanda A, Kadiiska MB, Michelotti G, Manautou J, Diehl AM, Chatterjee S. Toxicol Appl Pharmacol 274: 42-54, 2014; Seth RK, Kumar A, Das S, Kadiiska MB, Michelotti G, Diehl AM, Chatterjee S...
January 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/26253278/mtor-and-its-tight-regulation-for-inkt-cell-development-and-effector-function
#12
REVIEW
Wei Yang, Balachandra Gorentla, Xiao-Ping Zhong, Jinwook Shin
Invariant NKT (iNKT) cells, which express the invariant Vα14Jα18 TCR that recognizes lipid antigens, have the ability to rapidly respond to agonist stimulation, producing a variety of cytokines that can shape both innate and adaptive immunity. iNKT cells have been implicated in host defense against microbial infection, in anti-tumor immunity, and a multitude of diseases such as allergies, asthma, graft versus host disease, and obesity. Emerging evidence has demonstrated crucial role for mammalian target of rapamycin (mTOR) in immune cells, including iNKT...
December 2015: Molecular Immunology
https://www.readbyqxmd.com/read/26201093/innate-cellular-sources-of-interleukin-17a-regulate-macrophage-accumulation-in-cigarette-smoke-induced-lung-inflammation-in-mice
#13
Steven Bozinovski, Huei Jiunn Seow, Sheau Pyng Jamie Chan, Desiree Anthony, Jonathan McQualter, Michelle Hansen, Brendan J Jenkins, Gary P Anderson, Ross Vlahos
Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD). Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung immunity and inflammation. The aim of the present study was to investigate how IL-17A regulates CS-induced lung inflammation in vivo. IL-17A knockout (KO) mice and neutralization of IL-17A in wild-type (WT) mice reduced macrophage and neutrophil recruitment and chemokine (C-C motif) ligand 2 (CCL2), CCL3 and matrix metalloproteinase (MMP)-12 mRNA expression in response to acute CS exposure...
November 2015: Clinical Science (1979-)
https://www.readbyqxmd.com/read/26136917/treatment-with-incomplete-freund-s-adjuvant-and-listeria-monocytogenes-delays-diabetes-via-an-interleukin-17-secretion-independent-pathway
#14
Hai-Ping Wang, Zhi-Gao He
Non-obese diabetes (NOD) mice are widely used as an animal model in studies of type I diabetes (TID). Treatment with complete Freund's adjuvant (CFA) in pro-diabetic NOD mice is known to inhibit disease progression by activating CD1d-specific natural killer (NK) T cells and inducing interleukin (IL)-17 secretion in innate immune cells. The aim of the present study was to examine the effect of incomplete Freund's adjuvant (IFA) and L. monocytogenes treatment on the development of TID in NOD mice. This combined treatment of IFA and L...
May 2015: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/26059375/lactobacillus-casei-crl-431-administration-decreases-inflammatory-cytokines-in-a-diet-induced-obese-mouse-model
#15
Ivanna Novotny Núñez, Carolina Maldonado Galdeano, Alejandra de Moreno de LeBlanc, Gabriela Perdigón
OBJECTIVES: Obesity is a chronic disease associated with an inflammatory process in which cytokines play an important role. Probiotic microorganisms have been associated with modulation of the host immune system. The aim of this study was to evaluate the influence of the probiotic bacterium Lactobacillus casei CRL 431 on the cytokine response in a model of mice under high-fat diet (HFD) conditions. METHODS: BALB/c mice received a conventional balanced diet or an HFD...
July 2015: Nutrition
https://www.readbyqxmd.com/read/25646857/molecular-basis-of-carcinogenesis-in-diabetic-patients-review
#16
REVIEW
Artur Matyszewski, Anna M Czarnecka, Wojciech Solarek, Piotr Korzeń, Ilan J Safir, Wojciech Kukwa, Cezary Szczylik
The most important molecular mechanisms promoting carcinogenesis in patients with diabetes mellitus (DM) include oxidative stress, excessive generation of free radicals and nitrous oxide, damage to cellular membranes and DNA, overproduction of lactate, overabundance of protein glycosylation storage products, overexpression of pathological enzyme isoforms, and leakage of cytochromes from organelles. Additionally, dysfunctional signal transduction pathways, especially in pathways involving phosphoinositide 3‑kinase (PI3K)/phosphatase and tensin homolog (PTEN)/Akt, RAS/Raf/ERK, and mammalian target of rapamycin (mTOR), have been implicated in malignant transformation and progression...
April 2015: International Journal of Oncology
https://www.readbyqxmd.com/read/25536344/t-cell-factor-1-controls-the-lifetime-of-cd4-cd8-thymocytes-in-vivo-and-distal-t-cell-receptor-%C3%AE-chain-rearrangement-required-for-nkt-cell-development
#17
Archna Sharma, Rosa Berga-Bolaños, Jyoti Misra Sen
Natural killer T (NKT) cells are a component of innate and adaptive immune systems implicated in immune, autoimmune responses and in the control of obesity and cancer. NKT cells develop from common CD4+ CD8+ double positive (DP) thymocyte precursors after the rearrangement and expression of T cell receptor (TCR) Vα14-Jα18 gene. Temporal regulation and late appearance of Vα14-Jα18 rearrangement in immature DP thymocytes has been demonstrated. However, the precise control of lifetime of DP thymocytes in vivo that enables distal rearrangements remains incompletely defined...
2014: PloS One
https://www.readbyqxmd.com/read/25335766/the-influence-of-macronutrients-on-splanchnic-and-hepatic-lymphocytes-in-aging-mice
#18
David G Le Couteur, Szun S Tay, Samantha Solon-Biet, Patrick Bertolino, Aisling C McMahon, Victoria C Cogger, Feyza Colakoglu, Alessandra Warren, Andrew J Holmes, Nicolas Pichaud, Martin Horan, Carolina Correa, Richard G Melvin, Nigel Turner, J William O Ballard, Kari Ruohonen, David Raubenheimer, Stephen J Simpson
There is a strong association between aging, diet, and immunity. The effects of macronutrients and energy intake on splanchnic and hepatic lymphocytes were studied in 15 month old mice. The mice were ad-libitum fed 1 of 25 diets varying in the ratios and amounts of protein, carbohydrate, and fat over their lifetime. Lymphocytes in liver, spleen, Peyers patches, mesenteric lymph nodes, and inguinal lymph nodes were evaluated using flow cytometry. Low protein intake reversed aging changes in splenic CD4 and CD8 T cells, CD4:CD8 T cell ratio, memory/effector CD4 T cells and naïve CD4 T cells...
December 2015: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/25224267/characterization-of-immune-cells-in-psoriatic-adipose-tissue
#19
Shawn Rose, Elena Stansky, Pradeep K Dagur, Leigh Samsel, Elizabeth Weiner, Amir Jahanshad, Julia Doveikis, Haley B Naik, Martin P Playford, J Philip McCoy, Nehal N Mehta
BACKGROUND: Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity and diabetes mellitus. Psoriasis is associated with increased risk for metabolic disease, which may in part be due to adipose dysfunction, which has not been investigated in psoriasis. There is currently no standardized method for immunophenotyping human adipose tissue. In prior studies, characteristic phenotypic markers of immune cell populations identified in animal models or in other human tissues have been applied in a similar manner to human adipose tissue...
September 16, 2014: Journal of Translational Medicine
https://www.readbyqxmd.com/read/24966328/cd1d-mediated-presentation-of-endogenous-lipid-antigens-by-adipocytes-requires-microsomal-triglyceride-transfer-protein
#20
Maryam Rakhshandehroo, Sanne M W Gijzel, Rasmus Siersbæk, Marjoleine F Broekema, Colin de Haar, Henk S Schipper, Marianne Boes, Susanne Mandrup, Eric Kalkhoven
Obesity-induced adipose tissue (AT) dysfunction results in a chronic low-grade inflammation that predisposes to the development of insulin resistance and type 2 diabetes. During the development of obesity, the AT-resident immune cell profile alters to create a pro-inflammatory state. Very recently, CD1d-restricted invariant (i) natural killer T (NKT) cells, a unique subset of lymphocytes that are reactive to so called lipid antigens, were implicated in AT homeostasis. Interestingly, recent data also suggest that human and mouse adipocytes can present such lipid antigens to iNKT cells in a CD1d-dependent fashion, but little is known about the lipid antigen presentation machinery in adipocytes...
August 8, 2014: Journal of Biological Chemistry
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