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Concepts of Environmental Health

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https://www.readbyqxmd.com/read/28719406/toward-a-biopsychosocial-ecology-of-the-human-microbiome-brain-gut-axis-and-health
#1
Karl J Maier, Mustafa al'Absi
OBJECTIVE: Rapidly expanding insights to the human microbiome and health suggest that Western medicine is poised for significant evolution, or perhaps revolution - this while the field continues on a trajectory from reductionism to a biopsychosocial (BPS) paradigm recognizing biological, psychological, and social influences on health. The apparent sensitivity of the microbiota to perturbations across BPS domains suggests that a broad and inclusive framework is needed to develop applicable knowledge in this area...
July 18, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28716338/changing-innovation-into-a-registered-product-from-concept-to-regulatory-approval
#2
Linda Rhodes
Innovation in animal health pharmaceuticals is important to address unmet and underserved medical needs, and often comes from products initially developed for human medicine. The purpose of the review is to help readers understand how breakthroughs from human biotechnology may be developed for use in veterinary medicine, while understanding the key drivers to success, the difficulties of regulatory approval, and the realistic risks and rewards of developing applications for animals. The types of human drugs which may be useful for veterinary applications are reviewed, including examples...
July 6, 2017: Theriogenology
https://www.readbyqxmd.com/read/28713068/implementation-of-good-laboratory-practices-glp-in-basic-scientific-research-translating-the-concept-beyond-regulatory-compliance
#3
REVIEW
G B Jena, Sapana Chavan
The principles of Good Laboratory Practices (GLPs) are mainly intended for the laboratories performing studies for regulatory compliances. However, today GLP can be applied to broad disciplines of science to cater to the needs of the experimental objectives, generation of quality data and assay reproducibility. Considering its significance, it can now be applied in academics; industries as well as government set ups throughout the world. GLP is the best way to promote the reliability, reproducibility of the test data and hence facilitates the international acceptability...
July 13, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28711809/assessing-the-impact-of-hazardous-waste-on-children-s-health-the-exposome-paradigm
#4
D A Sarigiannis
Assessment of the health impacts related to hazardous waste is a major scientific challenge with multiple societal implications. Most studies related to associations between hazardous waste and public health do not provide established of mechanistic links between environmental exposure and disease burden, resulting in ineffective waste management options. The exposome concept comes to overhaul the nature vs. nurture paradigm and embraces a world of dynamic interactions between environmental exposures, endogenous exposures and genetic expression in humans...
July 13, 2017: Environmental Research
https://www.readbyqxmd.com/read/28710141/perspective-improving-nutritional-guidelines-for-sustainable-health-policies-current-status-and-perspectives
#5
Paolo Magni, Dennis M Bier, Sergio Pecorelli, Carlo Agostoni, Arne Astrup, Furio Brighenti, Robert Cook, Emanuela Folco, Luigi Fontana, Robert A Gibson, Ranieri Guerra, Gordon H Guyatt, John Pa Ioannidis, Ann S Jackson, David M Klurfeld, Maria Makrides, Basil Mathioudakis, Alessandro Monaco, Chirag J Patel, Giorgio Racagni, Holger J Schünemann, Raanan Shamir, Niv Zmora, Andrea Peracino
A large body of evidence supports the notion that incorrect or insufficient nutrition contributes to disease development. A pivotal goal is thus to understand what exactly is appropriate and what is inappropriate in food ingestion and the consequent nutritional status and health. The effective application of these concepts requires the translation of scientific information into practical approaches that have a tangible and measurable impact at both individual and population levels. The agenda for the future is expected to support available methodology in nutrition research to personalize guideline recommendations, properly grading the quality of the available evidence, promoting adherence to the well-established evidence hierarchy in nutrition, and enhancing strategies for appropriate vetting and transparent reporting that will solidify the recommendations for health promotion...
July 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28709428/a-systematic-comparison-of-statistical-methods-to-detect-interactions-in-exposome-health-associations
#6
Jose Barrera-Gómez, Lydiane Agier, Lützen Portengen, Marc Chadeau-Hyam, Lise Giorgis-Allemand, Valérie Siroux, Oliver Robinson, Jelle Vlaanderen, Juan R González, Mark Nieuwenhuijsen, Paolo Vineis, Martine Vrijheid, Roel Vermeulen, Rémy Slama, Xavier Basagaña
BACKGROUND: There is growing interest in examining the simultaneous effects of multiple exposures and, more generally, the effects of mixtures of exposures, as part of the exposome concept (being defined as the totality of human environmental exposures from conception onwards). Uncovering such combined effects is challenging owing to the large number of exposures, several of them being highly correlated. We performed a simulation study in an exposome context to compare the performance of several statistical methods that have been proposed to detect statistical interactions...
July 14, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28709012/de-escalation-of-aggressive-behaviour-in-healthcare-settings-concept-analysis
#7
REVIEW
Nutmeg Hallett, Geoffrey L Dickens
BACKGROUND: De-escalation is the recommended first-line response to potential violence and aggression in healthcare settings. Related scholarly activity has increased exponentially since the 1980s, but there is scant research about its efficacy and no guidance on what constitutes the gold standard for practice. OBJECTIVES: To clarify the concept of de-escalation of violence and aggression as described within the healthcare literature. DESIGN: Concept analysis guided by Rodgers' evolutionary approach...
July 4, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28700609/organic-farming-enhances-soil-microbial-abundance-and-activity-a-meta-analysis-and-meta-regression
#8
Martina Lori, Sarah Symnaczik, Paul Mäder, Gerlinde De Deyn, Andreas Gattinger
Population growth and climate change challenge our food and farming systems and provide arguments for an increased intensification of agriculture. A promising option is eco-functional intensification through organic farming, an approach based on using and enhancing internal natural resources and processes to secure and improve agricultural productivity, while minimizing negative environmental impacts. In this concept an active soil microbiota plays an important role for various soil based ecosystem services such as nutrient cycling, erosion control and pest and disease regulation...
2017: PloS One
https://www.readbyqxmd.com/read/28694198/survival-with-smog-and-smoke-precision-intervention
#9
Hua Linda Cai, Chen Wang
Despite continuous efforts of regional government agencies, air pollution remains a major threat to public health worldwide. In the January of 2017, a severe episode of smog similar to the London Fog in 1952, appeared in London. A longest episode of Chinese Haze also developed in Beijing, during which the PM2.5 (particular matter sized less than 2.5 micrometers) levels rose up to 500 μg/m(3). The European smog and the Chinese Haze are associated with large numbers of premature deaths each year, at 400,000 and 1...
July 7, 2017: Chest
https://www.readbyqxmd.com/read/28686952/urban-natural-environments-as-nature-based-solutions-for-improved-public-health-a-systematic-review-of-reviews
#10
M van den Bosch, Å Ode Sang
Increasing urbanisation, changing disease scenarios, and current predictions of climate change impacts require innovative strategies for providing healthy and sustainable cities, now and in the future. The recently coined concept, Nature-based solutions (NBS), is one such strategy referring to actions that are inspired by, supported by, or copied from nature, designed to address a range of environmental challenges. The objective with this article is to evaluate the evidence on public health benefits of exposure to natural environments and explore how this knowledge could be framed within the NBS concept...
July 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28679453/healthy-ageing-resilience-and-wellbeing
#11
T D Cosco, K Howse, C Brayne
The extension of life does not appear to be slowing, representing a great achievement for mankind as well as a challenge for ageing populations. As we move towards an increasingly older population we will need to find novel ways for individuals to make the best of the challenges they face, as the likelihood of encountering some form of adversity increases with age. Resilience theories share a common idea that individuals who manage to navigate adversity and maintain high levels of functioning demonstrate resilience...
July 6, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28673401/an-exposome-perspective-early-life-events-and-immune-development-in-a-changing-world
#12
REVIEW
Harald Renz, Patrick G Holt, Michael Inouye, Alan C Logan, Susan L Prescott, Peter D Sly
Advances in metagenomics, proteomics, metabolomics, and systems biology are providing a new emphasis in research; interdisciplinary work suggests that personalized medicine is on the horizon. These advances are illuminating sophisticated interactions between human-associated microbes and the immune system. The result is a transformed view of future prevention and treatment of chronic noncommunicable diseases, including allergy. Paradigm-shifting gains in scientific knowledge are occurring at a time of rapid global environmental change, urbanization, and biodiversity losses...
July 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28673078/nutritional-and-metabolic-programming-during-the-first-thousand-days-of-life
#13
Massimo Agosti, Francesco Tandoi, Laura Morlacchi, Angela Bossi
The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development, are able to modify, through epigenetic mechanisms, gene expression of DNA, resulting in adaptive modifications of phenotype to the environment, which may reflect negatively on the health of every individual. This concept, applied to nutrition, has opened up important prospects for research in this area...
June 28, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/28668347/managing-hazards-in-place-the-risks-of-residual-risks
#14
Ellen K Silbergeld
Managing hazards in place (MHP) is a policy instrument in environmental health that allows less than complete removal, abatement, or remediation of environmental hazards. The practice of minimizing exposure to hazards rather than removing them is widely recognized as part of the toolbox of environmental protection for human and ecosystem health. The concept of managing hazards in place is embedded in several environmental statutes and regulations in the US notably the waste management regulations, as well as in the Safe Drinking Water Act and the Clean Water Act...
June 28, 2017: Environmental Research
https://www.readbyqxmd.com/read/28667066/redox-theory-of-aging-implications-for-health-and-disease
#15
REVIEW
Young-Mi Go, Dean P Jones
Genetics ultimately defines an individual, yet the phenotype of an adult is extensively determined by the sequence of lifelong exposures, termed the exposome. The redox theory of aging recognizes that animals evolved within an oxygen-rich environment, which created a critical redox interface between an organism and its environment. Advances in redox biology show that redox elements are present throughout metabolic and structural systems and operate as functional networks to support the genome in adaptation to environmental resources and challenges during lifespan...
July 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28666298/food-insecurity-prenatal-care-and-other-anemia-determinants-in-pregnant-women-from-the-nisami-cohort-brazil-hierarchical-model-concept
#16
Fran Demétrio, Carlos Antônio de Souza Teles-Santos, Djanilson Barbosa Dos Santos
Objective To identify the prevalence of anemia and its relation to food insecurity (FI) and other determinants in pregnant women. Methods A cross-sectional, cohort-nested study, with the participation of 245 pregnant women who were cared for at Family Health Units in the municipality of Santo Antônio de Jesus, Bahia, Brazil. The participants underwent blood tests for hemoglobin levels, anthropometric examinations, and answered a structured questionnaire. The hemoglobin (Hb) parameter (Hb < 11 g/dL) was used for the classification of the diagnosis of anemia...
June 30, 2017: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28663175/cancer-and-race-what-they-tell-us-about-the-emerging-focus-of-health-equity
#17
Keith Wailoo
This article examines the history of concepts and frames (such as "equity" or "disparities") and how these frames have guided public policies and explanations about differences in health across the population. Considering the emblematic case of cancer, which has stimulated long and heated debate over social, economic, and biological causes, the article argues that the vocabularies of health reform are both semantic and also deeply political-framing different reform agendas. The article describes the evolving US debate over the biological, social, or environmental origins of differential cancer mortality along lines of social difference and race, tracing important shifts and reversal over time...
June 29, 2017: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/28660894/proteostasis-in-cardiac-health-and-disease
#18
REVIEW
Robert H Henning, Bianca J J M Brundel
The incidence and prevalence of cardiac diseases, which are the main cause of death worldwide, are likely to increase because of population ageing. Prevailing theories about the mechanisms of ageing feature the gradual derailment of cellular protein homeostasis (proteostasis) and loss of protein quality control as central factors. In the heart, loss of protein patency, owing to flaws in genetically-determined design or because of environmentally-induced 'wear and tear', can overwhelm protein quality control, thereby triggering derailment of proteostasis and contributing to cardiac ageing...
June 29, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28656108/home-features-and-assistive-technology-for-the-home-bound-elderly-in-a-thai-suburban-community-by-applying-the-international-classification-of-functioning-disability-and-health
#19
Supawadee Putthinoi, Suchitporn Lersilp, Nopasit Chakpitak
The ageing population is having an impact worldwide and has created a serious challenge in Thailand's healthcare systems, whereby healthcare practitioners play a major role in promoting independent interaction of their client's abilities, as well as environmental factors. The purpose of this study was to survey features of the home and assistive technology (AT) for the home-bound elderly in the community of Chiang Mai, Thailand. Home evaluation included features inside and outside the home, and AT was based on the International Classification of Functioning, Disability, and Health (ICF) concept...
2017: Journal of Aging Research
https://www.readbyqxmd.com/read/28645969/protocol-for-the-residents-in-action-pilot-cluster-randomised-controlled-trial-riat-evaluating-a-behaviour-change-intervention-to-promote-walking-reduce-sitting-and-improve-mental-health-in-physically-inactive-older-adults-in-retirement-villages
#20
Cecilie Thøgersen-Ntoumani, Ashlene Wright, Eleanor Quested, Elissa Burton, Keith D Hill, Ester Cerin, Stuart J H Biddle, Nikos Ntoumanis
INTRODUCTION: Ageing is accompanied by increased risks of chronic disease, declined functioning and increased dependency. Physical activity is critical to retaining health and independence, but the majority of older people are insufficiently physically active to achieve these benefits and have high levels of sedentary (sitting) time. Activity programmes are often offered in retirement villages; however, their uptake is limited. Furthermore, although the physical environment in and around these villages can play an important role in decisions to be physically active, its role is often overlooked by research in these settings...
June 23, 2017: BMJ Open
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