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https://www.readbyqxmd.com/read/29141061/a-randomized-investigator-blinded-comparison-of-two-topical-regimens-in-fitzpatrick-skin-types-iii-vi-with-moderate-to-severe-facial-hyperpigmentation
#1
Monique J Vanaman Wilson, Isabela T Jones, Joanna Bolton, Lisa Larsen, Douglas C Wu, Mitchel P Goldman
<p>Purpose: Though hydroquinone (HQ) remains the gold standard for treatment of hyperpigmentation, concerns about its safety have prompted the development of HQ-free topical skin lightening systems. OBJECTIVE: To compare the efficacy and tolerability of a new HQ-free system and a popular HQ-based system for the improvement of facial hyperpigmentation and photoaging in darker skin types. METHODS: This investigator-blinded trial randomized 30 subjects of Fitzpatrick skin types III to VI with moderate to severe hyperpigmentation to a new 7-product HQ-free system or a 7-product HQ-based system for 12 weeks...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29135799/peripapillary-pachychoroid-syndrome
#2
Nopasak Phasukkijwatana, K Bailey Freund, Rosa Dolz-Marco, Mayss Al-Sheikh, Pearse A Keane, Catherine A Egan, Sandeep Randhawa, Jay M Stewart, Qingyun Liu, Alex P Hunyor, Allan Kreiger, Aaron Nagiel, Robert Lalane, Mansour Rahimi, Won Ki Lee, Lee Merrill Jampol, David Sarraf
PURPOSE: To describe the features of peripapillary pachychoroid syndrome (PPS), a novel pachychoroid disease spectrum (PDS) entity. METHODS: Medical records of 31 eyes (16 patients) with choroidal thickening associated with intraretinal and/or subretinal fluid in the nasal macula extending from the disk were reviewed (patients with PPS). Choroidal thickness was compared with 2 age-matched cohorts: typical PDS (17 eyes with central serous chorioretinopathy or pachychoroid neovasculopathy) and 19 normal eyes...
November 10, 2017: Retina
https://www.readbyqxmd.com/read/29134790/soybean-mosaic-virus-a-successful-potyvirus-with-a-wide-distribution-but-restricted-natural-host-range
#3
M R Hajimorad, L L Domier, S A Tolin, S A Whitham, M A Saghai Maroof
Taxonomy. Soybean mosaic virus (SMV) is a species within the genus Potyvirus, family Potyviridae that includes almost a quarter of all known plant RNA viruses affecting agriculturally important plants. The Potyvirus genus is the largest of all genera of plant RNA viruses with 160 species. Particle. The filamentous particles of SMV, typical of potyviruses, are about 7,500 Å long and 120 Å in diameter with a central hole of about 15 Å in diameter. Coat protein residues are arranged in helice of about 34 Å pitch having slightly less than 9 subunits per turn...
November 14, 2017: Molecular Plant Pathology
https://www.readbyqxmd.com/read/29134340/rapid-visual-detection-of-lily-mottle-virus-using-a-loop-mediated-isothermal-amplification-method
#4
Binan Zhao, Dan Yang, Yongchun Zhang, Yan Xu, Xiao Zhao, Jieling Liang, Xiaorui Fan, Yanan Du, Ziping Zhu, Bin Shi, Qi Zhang, Xiaoxia Zhang, Youming Cai, Kai Zhao
Lily mottle virus (LMoV; genus Potyvirus, family Potyviridae) infects plants of the genus Lilium, causing a reduction in flower and bulb quality. A rapid and sensitive loop-mediated isothermal amplification (LAMP) assay was developed to detect the coat protein gene of LMoV. This LAMP method was highly specific for LMoV, with no cross-reaction with other lily viruses. The sensitivity of LMoV using the LAMP assay was 100 times more sensitive than that using conventional polymerase chain reaction. A reverse transcription LAMP (RT-LAMP) was then successfully applied to detect LMoV RNA...
November 14, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29116178/alternative-application-of-an-affinity-purification-tag-hexahistidines-in-ester-hydrolysis
#5
Lise Schoonen, Kayleigh S van Esterik, Chunqiu Zhang, Rein V Ulijn, Roeland J M Nolte, Jan C M van Hest
Hexahistidines are very common tags used in the affinity chromatography purification of recombinant proteins. Although these tags are solely applied for their metal-binding properties, we found that they are also able to perform ester hydrolysis when attached to a protein. For instance, green fluorescent protein (GFP) and the cowpea chlorotic mottle virus (CCMV) are able to perform catalysis after introduction of the His-tag. By attaching a His-tag to an enzyme, a dual-functional catalyst was created, that can perform a two-step cascade reaction...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29109872/severe-decompression-illness-case-report-prehospital-recognition-and-regional-transport-considerations
#6
Julie Estrada, David Meurer, Kevin De Boer, Karl Huesgen
A 46-year-old male presented to our tertiary care emergency department (ED) with shortness of breath and chest pain following an uneventful four-hour SCUBA dive at 100 feet. His prehospital emergency medical services (EMS) assessment revealed transient hypotension and hypoxia. He later developed progressive skin mottling. Serology was significant for acute kidney injury, transaminitis, hemoconcentration, and hypoxia on an arterial blood gas. Computed tomography (CT) angiography demonstrated intravascular gas throughout the mesenteric and pulmonary arteries as well as the portal venous system...
2017: Case Reports in Emergency Medicine
https://www.readbyqxmd.com/read/29098985/investigating-the-thermal-dissociation-of-viral-capsid-by-lattice-model
#7
Jingzhi Chen, Maelenn Chevreuil, Sophie Combet, Yves Lansac, Guillaume Tresset
The dissociation of icosahedral viral capsids was investigated by a homogeneous and a heterogeneous lattice model. In thermal dissociation experiments with cowpea chlorotic mottle virus and probed by small-angle neutron scattering, we observed a slight shrinkage of viral capsids, which can be related to the strengthening of the hydrophobic interaction between subunits at increasing temperature. By considering the temperature dependence of hydrophobic interaction in the homogeneous lattice model, we were able to give a better estimate of the effective charge...
November 3, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29098656/virological-quality-of-irrigation-water-sources-and-pepper-mild-mottle-virus-and-tobacco-mosaic-virus-as-index-of-pathogenic-virus-contamination-level
#8
Sadhana Shrestha, Shankar Shrestha, Junko Shindo, Jeevan B Sherchand, Eiji Haramoto
Irrigation water is a doorway for the pathogen contamination of fresh produce. We quantified pathogenic viruses [human adenoviruses, noroviruses of genogroups I and II, group A rotaviruses, Aichi virus 1 (AiV-1), enteroviruses (EnVs), and salivirus (SaliV)] and examined potential index viruses [JC and BK polyomaviruses (JCPyVs and BKPyVs), pepper mild mottle virus (PMMoV), and tobacco mosaic virus (TMV)] in irrigation water sources in the Kathmandu Valley, Nepal. River, sewage, wastewater treatment plant (WWTP) effluent, pond, canal, and groundwater samples were collected in September 2014, and in April and August 2015...
November 2, 2017: Food and Environmental Virology
https://www.readbyqxmd.com/read/29097464/complete-genome-sequence-of-a-new-strain-of-rice-yellow-mottle-virus-from-malawi-characterized-by-a-recombinant-vpg-protein
#9
Innocent Ndikumana, Agnès Pinel-Galzi, Denis Fargette, Eugénie Hébrard
The complete sequence of the isolate Mw10 of Rice yellow mottle virus was determined. Sequence comparisons revealed 8.4% to 10.7% nucleotide divergence from the published sequences, resulting in the definition of the strain S7. Importantly, a putative recombination event was identified encompassing the viral genome-linked protein involved in host adaptation.
November 2, 2017: Genome Announcements
https://www.readbyqxmd.com/read/29096303/pretreatment-with-propidium-monoazide-sodium-lauroyl-sarcosinate-improves-discrimination-of-infectious-waterborne-virus-by-rt-qpcr-combined-with-magnetic-separation
#10
Hae-Won Lee, Hee-Min Lee, So-Ra Yoon, Sung Hyun Kim, Ji-Hyoung Ha
RT-qPCR allows sensitive detection of viral particles of both infectious and noninfectious viruses in water environments, but cannot discriminate non-infectious from infectious viruses. In this study, we aimed to optimize RT-qPCR-based detection of chlorine-inactivated human norovirus (NoV) and pepper mild mottle virus (PMMoV) in suspension by pretreatment with an optimal combination of a monoazide and a detergent that can efficiently penetrate damaged viral capsids. Four methods were compared to determine the efficacy of chlorine disinfection (at 1, 3, and 5 min mg/L): (A) RT-qPCR alone, (B) RT-qPCR assay preceded by magnetic bead separation for enrichment of viral particles (MBS-RT-qPCR), (C) MBS-RT-qPCR assay with pretreatment with propidium monoazide (PMA-MBS-RT-qPCR), and (D) PMA-MBS-RT-qPCR assay with pretreatment with sodium lauroyl sarcosinate (INCI-PMA-MBS-RT-qPCR)...
October 27, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29068372/deep-sequencing-data-and-infectivity-assays-indicate-that-chickpea-chlorotic-dwarf-virus-is-the-etiological-agent-of-the-hard-fruit-syndrome-of-watermelon
#11
Takoua Zaagueri, Laura Miozzi, Monia Mnari-Hattab, Emanuela Noris, Gian Paolo Accotto, Anna Maria Vaira
Chickpea chlorotic dwarf virus (CpCDV), a polyphagous mastrevirus, family Geminiviridae, has been recently linked to the onset of the "hard fruit syndrome" of watermelon, first described in Tunisia, that makes fruits unmarketable due to the presence of white hard portions in the flesh, chlorotic mottling on the rind, and an unpleasant taste. To investigate the etiological agent of this disease, total RNA extracted from symptomatic watermelon fruits was subjected to small RNA sequencing through next generation sequencing (NGS) techniques...
October 25, 2017: Viruses
https://www.readbyqxmd.com/read/29057567/q-switched-nd-yag-laser-alone-or-with-modified-jessner-chemical-peeling-for-treatment-of-mixed-melasma-in-dark-skin-types-a-comparative-clinical-histopathological-and-immunohistochemical-study
#12
Fatma Saleh, Noha H Moftah, Eman Abdel-Azim, Marwa G Gharieb
BACKGROUNDS: Treatment of mixed melasma remains challenging. Promising results have been achieved with low-fluence 1064-nm Q-switched Nd-YAG laser; however, multiple sessions are necessary with occurrence of complications especially in dark skin types. So, combination methods may be recommended. AIMS: To compare efficacy of Q-switched Nd-YAG laser alone or with modified Jessner's peel in mixed melasma in dark skin. PATIENTS/METHODS: Nineteen patients with mixed melasma received 6 sessions of laser on left side of face and alternating laser and modified Jessner on right side...
October 22, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29045012/photodynamic-therapy-inhibits-melanogenesis-through-paracrine-effects-by-keratinocytes-and-fibroblasts
#13
Sue Kyung Kim, Seung-Jae Oh, Se-Yeon Park, Woo-Jung Kim, You-Sun Kim, You Chan Kim
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In the present study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes in vitro and in vivo. Exposure of melanocytes to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing melanocytes to conditioned media of PDT-treated keratinocytes or dermal fibroblasts...
October 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29018310/virus-incidence-of-sweet-potato-in-korea-from-2011-to-2014
#14
Jaedeok Kim, Jung Wook Yang, Hae-Ryun Kwak, Mi-Kyeong Kim, Jang-Kyun Seo, Mi-Nam Chung, Hyeong-Un Lee, Kyeong-Bo Lee, Sang Sik Nam, Chang-Seok Kim, Gwan-Seok Lee, Jeong-Soo Kim, Sukchan Lee, Hong-Soo Choi
A nationwide survey was performed to investigate the current incidence of viral diseases in Korean sweet potatoes for germplasm and growing fields from 2011 to 2014. A total of 83.8% of the germplasm in Korea was infected with viruses in 2011. Commercial cultivars that were used to supply growing fields were infected at a rate of 62.1% in 2012. Among surveyed viruses, the incidence of five Potyvirus species that infect sweet potato decreased between 2012 and 2013, and then increased again in 2014. Representatively, the incidence of Sweet potato feathery mottle virus (SPFMV) was 87...
October 2017: Plant Pathology Journal
https://www.readbyqxmd.com/read/28990483/identification-of-a-hypervirulent-pathotype-of-rice-yellow-mottle-virus-a-threat-to-genetic-resistance-deployment-in-west-central-africa
#15
Eugénie Hébrard, Agnès Pinel-Galzi, Aderonke Oludare, Nils Poulicard, Jamel Aribi, Sandrine Fabre, Souley Issaka, Cédric Mariac, Alexis Dereeper, Laurence Albar, Drissa Silué, Denis Fargette
Rice yellow mottle virus (RYMV) causes high losses to rice production in Africa. Several sources of varietal high resistance are available but the emergence of virulent pathotypes that are able to overcome one or two resistance alleles can sometimes occur. Both resistance spectra and viral adaptability have to be taken into account to develop sustainable rice breeding strategies against RYMV. In this study, we extended previous resistance spectrum analyses by testing the rymv1-4 and rymv1-5 alleles that are carried by the rice accessions Tog5438 and Tog5674, respectively, against isolates that are representative of RYMV genetic and pathogenic diversity...
October 9, 2017: Phytopathology
https://www.readbyqxmd.com/read/28989276/stability-of-medicines-after-repackaging-into-multicompartment-compliance-aids-eight-criteria-for-detection-of-visual-alteration
#16
Valerie Albert, Michael Lanz, Georgios Imanidis, Kurt E Hersberger, Isabelle Arnet
INTRODUCTION: Multicompartment compliance aids (MCA) are widely used by patients. They support the management of medication and reduce unintentional nonadherence. MCA are filled with medicines unpacked from their original packaging. Swiss pharmacists currently provide MCA for 1-2 weeks, although little and controversial information exists on the stability of repackaged medicines. OBJECTIVE: We aimed to validate the usefulness of a simple screening method capable of detecting visual stability problems with repackaged medicines...
2017: Drugs & Therapy Perspectives: for Rational Drug Selection and Use
https://www.readbyqxmd.com/read/28988983/molecular-characterization-of-two-badnavirus-genomes-associated-with-canna-yellow-mottle-disease
#17
Dulanjani Wijayasekara, Peter Hoyt, Austin Gimondo, Bruce Dunn, Aastha Thapa, Hannah Jones, Jeanmarie Verchot
Members of the genus Badnavirus have a single non-covalently closed circular double-stranded DNA genome of 7.2-9.2kb. The genome encodes three open reading frames (ORFs) on the positive DNA strand. Canna yellow mottle virus (CaYMV) is a badnavirus that has been described as the etiological cause of yellow mottle disease in canna, although only a 565bp fragment of the genome has been previously reported from cannas. In this report, concentrated virions were recovered from infected canna plants and nucleic acids were extracted...
October 5, 2017: Virus Research
https://www.readbyqxmd.com/read/28986801/virus-induced-gene-silencing-vigs-and-foreign-gene-expression-in-pisum-sativum-l-using-the-one-step-bean-pod-mottle-virus-bpmv-viral-vector
#18
Chouaïb Meziadi, Sophie Blanchet, Valérie Geffroy, Stéphanie Pflieger
Plant viral vectors have been developed to facilitate gene function studies especially in plant species not amenable to traditional mutational or transgenic modifications. In the Fabaceae plant family, the most widely used viral vector is derived from Bean pod mottle virus (BPMV). Originally developed for overexpression of foreign proteins and VIGS studies in soybean, we adapted the BPMV-derived vector for use in other legume species such as Phaseolus vulgaris and Pisum sativum. Here, we describe a protocol for efficient protein expression and virus-induced gene silencing (VIGS) in Pisum sativum leaves and roots using the "one-step" Bean pod mottle virus (BPMV) viral vector...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28978321/a-case-of-pseudoxanthoma-elasticum-with-proliferative-diabetic-retinopathy
#19
Keigo Kakurai, Maiko Hayashi, Kanako Yamada, Norihiko Ishizaki, Yumiko Yonemoto, Seita Morishita, Ryohsuke Kohmoto, Takaki Sato, Teruyo Kida, Tsunehiko Ikeda
BACKGROUND: To report the case of a patient with pseudoxanthoma elasticum (PXE) and proliferative diabetic retinopathy (PDR), and discuss the relationship between PXE and diabetic retinopathy (DR). CASE PRESENTATION: A 47-year-old man with PXE presented with angioid streaks and DR in both eyes, and bilateral panretinal photocoagulation was performed for treatment. Vitrectomy had previously been performed in his right eye for vitreous hemorrhage due to PDR. Systemic findings included multiple, discrete, symmetrical, small yellow papules bilaterally in the axilla and inguinal region...
October 4, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28971894/clusterin-in-the-mouse-epididymis-possible-roles-in-sperm-maturation-and-capacitation
#20
Arpornrad Saewu, Suraj Kadunganattil, Riya Raghupathy, Kessiri Kongmanas, Pamela Diaz Astudillo, Louis Hermo, Nongnuj Tanphaichitr
Clusterin (CLU) is known as an extracellular chaperone for proteins under stress, thus preventing them from aggregation and precipitation. We showed herein that CLU, expressed by principal cells of the mouse caput epididymis, was present in high amounts in the lumen. In the cauda epididymis, CLU bound tightly to the sperm head surface and its amount on total sperm was similar to that in the bathing luminal fluid. In both immotile and motile caudal epididymal sperm, CLU was localized over the entire sperm head except at the convex ridge, although in the motile sperm population the CLU immunofluorescence pattern was distinctively mottled with a lower intensity...
October 2, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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