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https://www.readbyqxmd.com/read/29351203/ttx-bearing-planocerid-flatworm-platyhelminthes-acotylea-in-the-ryukyu-islands-japan
#1
Hiroyuki Ueda, Shiro Itoi, Haruo Sugita
Polyclad flatworms comprise a highly diverse and cosmopolitan group of marine turbellarians. Although some species of the genera Planocera and Stylochoplana are known to be tetrodotoxin (TTX)-bearing, there are few new reports. In this study, planocerid-like flatworm specimens were found in the sea bottom off the waters around the Ryukyu Islands, Japan. The bodies were translucent with brown reticulate mottle, contained two conical tentacles with eye spots clustered at the base, and had a slightly frilled-body margin...
January 19, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29342012/diffuse-chorioretinopathy-without-serous-detachment-associated-with-cardiac-transplantation
#2
Michael F Marmor
PURPOSE: To analyze an unusual case of widespread chorioretinopathy after cardiac transplantation for its potential etiology and clinical significance. METHODS: Clinical examinations included widefield and macular color and fundus autofluorescence photography, spectral domain optical coherence tomography, fluorescein angiography and indocyanine green angiography, full-field electroretinography, and Goldmann visual fields. PATIENT: A 44-year-old Hispanic woman was referred to rule out retinitis pigmentosa...
January 16, 2018: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29336782/loss-of-gpnmb-causes-autosomal-recessive-amyloidosis-cutis-dyschromica-in-humans
#3
Chi-Fan Yang, Shuan-Pei Lin, Chien-Ping Chiang, Yu-Hung Wu, Weng Siong H'ng, Chun-Ping Chang, Yuan-Tsong Chen, Jer-Yuarn Wu
Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottled with small hypopigmented macules on the trunks and limbs. Affected families and sporadic case subjects have been reported predominantly in East and Southeast Asian ethnicities; however, the genetic cause has not been elucidated. We report here that the compound heterozygosity or homozygosity of GPNMB truncating alleles is the cause of autosomal-recessive ACD. Six nonsense or frameshift mutations were identified in nine individuals diagnosed with ACD...
January 9, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29322795/analysis-of-dna-methylation-and-microrna-expression-in-nut-nuclear-protein-in-testis-midline-carcinoma-of-the-sinonasal-tract-a-clinicopathological-immunohistochemical-and-molecular-genetic-study
#4
J Laco, H Kovarikova, M Chmelarova, H Vosmikova, K Sieglova, I Bubancova, P Dundr, K Nemejcova, J Michalek, P Celakovsky, R Mottl, I Sirak, M Vosmik, I Marek, T Geryk, J Mejzlik, J Satankova, A Ryska
The aim of this study was a detailed clinicopathological investigation of sinonasal NUT midline carcinoma (NMC), including analysis of DNA methylation and microRNA (miRNA) expression. Three (5%) cases of NMC were detected among 56 sinonasal carcinomas using immunohistochemical screening and confirmed by fluorescence in situ hybridization. The series comprised 2 males and 1 female, aged 46, 60, and 65 years. Two tumors arose in the nasal cavity and one in the maxillary sinus. The neoplasms were staged pT1, pT3, and pT4a (all cN0M0)...
2018: Neoplasma
https://www.readbyqxmd.com/read/29320586/safety-and-efficacy-of-a-1550nm-1927nm-dual-wavelength-laser-for-the-treatment-of-photodamaged-skin
#5
Vic A Narurkar, Tina S Alster, Eric F Bernstein, Tina J Lin, Anya Loncaric
<p>BACKGROUND: Fractional photothermolysis (FP) is a popular treatment option for photodamaged skin and addresses shortcomings of ablative skin resurfacing and nonablative dermal remodeling. Previous studies have demonstrated that FP using the 1550nm wavelength has led to improvement of ultrastructural changes and clinical effects associated with photodamaged skin in the deeper dermal structures, while treatment with the 1927nm wavelength has shown clinical effects in the superficial dermis. Both wavelengths produce precise microscopic treatment zones (MTZs) in the skin...
January 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29310664/pathogenicity-of-rice-yellow-mottle-virus-and-screening-of-rice-accessions-from-the-central-african-republic
#6
Regis Dimitri Sokpe Longue, Valentin Stanislas Edgar Traore, Innocent Zinga, Maxwell Darko Asante, Zakaria Bouda, James Bouma Neya, Nicolas Barro, Oumar Traore
BACKGROUND: Rice yellow mottle virus (RYMV) of the genus Sobemovirus is the most important viral pathogen of rice causing more damage to rice crop in Sub Saharan Africa. The aim of this study was to conduct pathogenic characterization of RYMV isolates from the Central African Republic (CAR) and to screen commonly cultivated rice accessions in the country for resistance/tolerance to the virus. METHODS: The pathogenicity of RYMV isolates was studied by mechanical inoculation with comparison to differential rice lines highly resistant to RYMV available at the Institute of Environment and Agricultural Research (INERA) in Burkina Faso...
January 8, 2018: Virology Journal
https://www.readbyqxmd.com/read/29306700/pepper-mild-mottle-virus-as-a-process-indicator-at-drinking-water-treatment-plants-employing-coagulation-sedimentation-rapid-sand-filtration-ozonation-and-biological-activated-carbon-treatments-in-japan
#7
Ryuichi Kato, Tatsuya Asami, Etsuko Utagawa, Hiroaki Furumai, Hiroyuki Katayama
To assess the potential of pepper mild mottle virus (PMMoV) as a viral process indicator, its reduction through coagulation-sedimentation (CS) and rapid sand filtration (RSF) were compared with those of Escherichia coli, previously used viral indicators, and norovirus genotype II (NoV GII; enteric virus reference pathogen) in a bench-scale experiment. PMMoV log10 reductions in CS (1.96 ± 0.30) and RSF (0.26 ± 0.38) were similar to those of NoV GII (1.86 ± 0.61 and 0.28 ± 0.46). PMMoV, the most abundant viruses in the raw water, was also determined during CS, RSF, and advanced treatment processes at two full-scale drinking water treatment plants under strict turbidity management over a 13-month period...
December 27, 2017: Water Research
https://www.readbyqxmd.com/read/29304160/a-retrospective-review-of-vital-signs-and-clinical-outcomes-of-febrile-infants-younger-than-3-months-old-presenting-to-the-emergency-department
#8
Shu-Ling Chong, Gene Yong-Kwang Ong, Wendy Yi Wen Chin, John Mingzhou Chua, Praseetha Nair, Alicia Shu Zhen Ong, Kee Chong Ng, Ian Maconochie
OBJECTIVES: Febrile infants younger than 3 months old present a diagnostic dilemma to the emergency physician. We aim to describe a large population of febrile infants less than 3 months old presenting to a pediatric emergency department (ED) and to assess the performance of current heart rate guidelines in the prediction of serious infections (SI). MATERIALS AND METHODS: We performed a retrospective review of febrile infants younger than 3 months old, between March 2015 and Feb 2016, in a large tertiary pediatric ED...
2018: PloS One
https://www.readbyqxmd.com/read/29296555/irritant-contact-keratitis-caused-by-the-bodily-fluids-of-a-brown-marmorated-stink-bug
#9
Yi-Syun Shen, Chao-Chien Hu
PURPOSE: The brown marmorated stink bug is native to Asia (China, Taiwan, Japan, and the Korean peninsula). Its bodily fluids are toxic and irritating to the human skin and eyes. Human case reports are rare. Only one report of irritant contact dermatitis has been published. We report a case of irritant contact keratitis resulting from the chemical components of the bodily fluids of the bug. MATERIALS AND METHODS: A case report. RESULTS: A 74-year-old male presented to our emergency department with pain and redness in his right eye, which had been exposed to the bodily fluids of a brown marmorated stink bug...
October 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29295571/the-96th-amino-acid-of-the-coat-protein-of-cucumber-green-mottle-mosaic-virus-affects-virus-infectivity
#10
Zhenwei Zhang, Liming Liu, Huijie Wu, Lifeng Liu, Baoshan Kang, Bin Peng, Qinsheng Gu
Cucumber green mottle mosaic virus (CGMMV) is one of the most devastating viruses infecting members of the family Cucurbitaceae. The assembly initiation site of CGMMV is located in the coding region of the coat protein, which is not only involved in virion assembly but is also a key factor determining the long-distance movement of the virus. To understand the effect of assembly initiation site and the adjacent region on CGMMV infectivity, we created a GTT deletion mutation in the GAGGTTG assembly initiation site of the infectious clone of CGMMV, which we termed V97 (deletion mutation at residue 97 of coat protein), followed by the construction of the V94A and T104A mutants...
December 25, 2017: Viruses
https://www.readbyqxmd.com/read/29289946/different-applicabilities-of-the-etch-bleach-seal-technique-for-treating-opacities-on-permanent-incisor-damage-by-molar-incisor-hypomineralisation-in-three-young-patients
#11
Tony Prud'homme, Isabelle Hyon, Sylvie Dajean Trutaud, Serena Lopez Cazaux
Enamel opacity on anterior teeth can be prejudicial for the aesthetic appearance of affected patients. Patients with molar incisor hypomineralisation, for example, present opacities that can range from discrete white mottling to extensive yellow-brown discolourations. They can request a treatment to improve their aesthetic conditions. Many techniques have been considered to manage this condition. Wright developed a technique called etch-bleach-seal, which showed promising results for the management of anterior enamel opacities...
December 29, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29287150/diverse-chromosomal-locations-of-quantitative-trait-loci-for-tolerance-to-maize-chlorotic-mottle-virus-in-five-maize-populations
#12
Mark W Jones, Bryan W Penning, Tiffany M Jamann, Jeff C Glaubitz, Cinta Romay, Edward S Buckler, Margaret Redinbaugh
The recent rapid emergence of maize lethal necrosis (MLN), caused by coinfection of maize with maize chlorotic mottle virus (MCMV) and a second virus usually from the family Potyviridae, is causing extensive losses for farmers in East Africa, Southeast Asia and South America. Although the genetic basis of resistance to potyviruses is well understood in maize, little was known about resistance to MCMV. The responses of five maize inbred lines (KS23-5, KS23-6, N211, DR and Oh1VI) to inoculation with MCMV, sugarcane mosaic virus and MLN were characterized...
December 29, 2017: Phytopathology
https://www.readbyqxmd.com/read/29280016/virome-analysis-of-lily-plants-reveals-a-new-potyvirus
#13
Yongqiang Li, Anning Jia, Yan Qiao, Jun Xiang, Yongjiang Zhang, Wenhe Wang
Lily plants exhibiting virus-like symptoms of leaf yellowing, twisting and brownish necrotic spots were collected, and next-generation sequencing of small RNAs was conducted to identify the associated viruses. Cucumber mosaic virus, lily symptomless virus and a hitherto unrecorded potyvirus, tentatively named "lily yellow mosaic virus" (LYMV), were detected. The genomic RNA of LYMV was 9811 nt in length, encoding a large polyprotein of 3,124 amino acids with a predicted Mr of 353.3 kDa. BLAST analysis showed that LYMV shared a high degree of amino acid sequence identity with Thunberg fritillary mosaic virus (55%), bean yellow mosaic virus (52%), clover yellow vein virus (51%), leek yellow stripe virus (51%), and lily mottle virus (52%), and these viruses clustered together in a phylogenetic tree...
December 26, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29273825/localization-and-subcellular-association-of-grapevine-pinot-gris-virus-in-grapevine-leaf-tissues
#14
Giulia Tarquini, Paolo Ermacora, Gian Luca Bianchi, Francesca De Amicis, Laura Pagliari, Marta Martini, Alberto Loschi, Pasquale Saldarelli, Nazia Loi, Rita Musetti
Despite the increasing impact of Grapevine Pinot gris disease (GPG-disease) worldwide, etiology about this disorder is still uncertain. The presence of the putative causal agent, the Grapevine Pinot Gris Virus (GPGV), has been reported in symptomatic grapevines (presenting stunting, chlorotic mottling, and leaf deformation) as well as in symptom-free plants. Moreover, information on virus localization in grapevine tissues and virus-plant interactions at the cytological level is missing at all. Ultrastructural and cytochemical investigations were undertaken to detect virus particles and the associated cytopathic effects in field-grown grapevine showing different symptom severity...
December 22, 2017: Protoplasma
https://www.readbyqxmd.com/read/29231176/tensorcalculator-exploring-the-evolution-of-mechanical-stress-in-the-ccmv-capsid
#15
Olga Kononova, Farkhad Maksudov, Kenneth A Marx, Valeri Barsegov
A new computational methodology for accurate numerical calculation of the Cauchy stress tensor, stress invariants, principal stress components, von Mises and Tresca tensors is developed. The methodology is based on the atomic stress approach which permits the calculation of stress tensors, widely used in continuum mechanics modeling of materials properties, using the output from the MD simulations of discrete atomic and Cα-based coarse-grained structural models of biological particles. The methodology mapped into software package TensorCalculator was successfully applied to the empty Cowpea Chlorotic Mottle virus (CCMV) shell to explore the evolution of mechanical stress in this mechanically-tested specific example of a soft virus capsid...
December 12, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29224131/characterization-of-tomato-leaf-curl-purple-vein-virus-a-new-monopartite-new-world-begomovirus-infecting-tomato-in-northeast-brazil
#16
M A Macedo, L C Albuquerque, M R Maliano, J O Souza, M R Rojas, A K Inoue-Nagata, R L Gilbertson
A new begomovirus species was identified from tomato plants with upward leaf curling and purple vein symptoms, which was first identified in the Piaui state of Northeast (NE) Brazil in 2014. Tomato leaf samples were collected in 2014 and 2016, and PCR with degenerate primers revealed begomovirus infection. Rolling circle amplification and restriction enzyme digestion indicated a single genomic DNA of ~ 2.6 kb. Cloning and sequencing revealed a genome organization similar to DNA-A components of New World (NW) bipartite begomoviruses, with no DNA-B...
December 9, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29219020/correlation-of-mri-appearance-of-autologous-chondrocyte-implantation-in-the-ankle-with-clinical-outcome
#17
Keith W Chan, Richard D Ferkel, Brian Kern, Sarah S Chan, Gregory R Applegate
The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS: Twenty-four grafts were evaluated at a mean 65.8 months after ACI for OLT. MRI was performed on a 1.5-T GE scanner using multiple sequences. Graft appearance was compared with preoperative MRI and evaluated for 6 criteria: defect fill, surface regularity, signal pattern, bone marrow edema, subchondral plate irregularity, and presence of cystic lesions...
January 2018: Cartilage
https://www.readbyqxmd.com/read/29210963/central-ellipsoid-loss-associated-with-cone-dystrophy-and-kcnv2-mutation
#18
David Xu, Daniel Su, Steven Nusinowitz, David Sarraf
PURPOSE: To report a case of central ellipsoid loss with supernormal rod electroretinogram and KCNV2 gene mutation. METHODS: Retrospective case report. PATIENT: Thirty-eight-year-old man. RESULTS: We report a patient with longstanding vision loss and photophobia who illustrated central atrophy of the inner segment ellipsoid zone band on spectral domain optical coherence tomography. Fundus autofluorescence displayed mild perifoveal mottled autofluorescence...
November 23, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29201043/clinical-and-genetic-review-of-hereditary-acral-reticulate-pigmentary-disorders
#19
REVIEW
H Alshaikh, F Alsaif, S Aldukhi
Reticulated pigmentation is a unique pigmentary change caused by a heterogeneous group of hereditary and acquired disorders. This pigmentation is characterized by a mottled appearance, with lesions that vary in size and pigmentary content. This review discusses the hereditary group of the reticulated pigmentation disorders, such as dyschromatosis symmetrica hereditaria, dyschromatosis universalis hereditaria, and reticulate acropigmentation of Kitamura. The clinical presentation and histopathological features often overlap, making diagnosis difficult...
2017: Dermatology Research and Practice
https://www.readbyqxmd.com/read/29196660/transcriptome-analysis-of-watermelon-citrullus-lanatus-fruits-in-response-to-cucumber-green-mottle-mosaic-virus-cgmmv-infection
#20
Xiaodong Li, Mengnan An, Zihao Xia, Xiaojiao Bai, Yuanhua Wu
Cucumber green mottle mosaic virus (CGMMV) belongs to the Tobamovirus genus and is a major global plant virus on cucurbit plants. It causes severe disease symptoms on infected watermelon plants (Citrullus lanatus), particularly inducing fruit decay. However, little is known about the molecular mechanism of CGMMV-induced watermelon fruit decay. For this study, comparative analysis of transcriptome profiles of CGMMV-inoculated and mock-inoculated watermelon fruits were conducted via RNA-Seq. A total of 1,621 differently expressed genes (DEGs) were identified in CGMMV-inoculated watermelon, among which 1,052 were up-regulated and 569 were down-regulated...
December 1, 2017: Scientific Reports
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