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Xiao-Nan Li

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https://www.readbyqxmd.com/read/28317980/biodistribution-excretion-and-toxicity-of-polyethyleneimine-modified-nayf4-yb-er-upconversion-nanoparticles-in-mice-via-different-administration-routes
#1
Jie Yu, Wenyan Yin, Tao Peng, Ya-Nan Chang, Yan Zu, Juan Li, Xiao He, Xiaoyan Ma, Zhanjun Gu, Yuliang Zhao
Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we chose polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles (abbreviated as PEI@UCNPs) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation in the spleen within 30 days...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28302212/-effects-of-%C3%AF-3-polyunsaturated-fatty-acids-on-lymphocyte-apoptosis-rate-in-rats-with-sepsis
#2
Hong-Jun Miao, Dan Wang, Xu-Hua Ge, Xiao-Nan Li
OBJECTIVE: To investigate the effects of ω-3 polyunsaturated fatty acids (ω-3 PUFAs) on the apoptosis of thymic and splenic lymphocytes in rats with sepsis. METHODS: A total of 80 female Sprague-Dawley rats aged 7-8 weeks were randomly divided into model group, conventional lipid emulsion group (0.1 g/kg daily), low-dose ω-3 PUFAs group (0.1 g/kg daily), middle-dose ω-3 PUFAs group (0.2 g/kg daily), and high-dose ω-3 PUFAs group (0.3 g/kg daily). Cecal ligation and puncture were used to establish a rat model of sepsis...
March 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28298295/t-cell-mineralocorticoid-receptor-controls-blood-pressure-by-regulating-interferon-gamma
#3
Xue Nan Sun, Chao Li, Yuan Liu, Lin-Juan Du, Meng-Ru Zeng, Xiao Jun Zheng, Wu Chang Zhang, Yan Liu, Mingjiang Zhu, Deping Kong, Li Zhou, Limin Lu, Zhu-Xia Shen, Yi Yi, Lili Du, Mu Qin, Xu Liu, Zichun Hua, Shuyang Sun, Huiyong Yin, Bin Zhou, Ying Yu, Zhiyuan Zhang, Sheng-Zhong Duan
Rationale: Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells and T cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used to treat hypertension. However, the function of T cell MR in blood pressure (BP) regulation has not been elucidated. Objective: We aim to determine the role of T cell MR in BP regulation and to explore the mechanism. Methods and Results: Using T cell MR knockout (TMRKO) mouse in combination with angiotensin II (AngII)-induced hypertensive mouse model, we demonstrated that MR deficiency in T cells strikingly decreased both systolic and diastolic BP, and attenuated renal and vascular damage...
March 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28291124/myc-protein-positive-diffuse-large-b-cell-lymphoma-features-an-activated-b-cell-receptor-signal-pathway
#4
Wei-Ge Wang, Xiang-Nan Jiang, Ze-Bing Liu, Xiao-Yan Zhou, Xiao-Qiu Li
Components of the B-cell receptor (BCR) signaling pathway represent promising therapeutic targets in diffuse large B-cell lymphoma (DLBCL) and other B-cell malignancies. MYC, a transcriptional factor and oncoprotein, is overexpressed in a fraction of DLBCL and indicates poor prognosis and aggressive clinical course when treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). However, BCR signaling status in MYC-positive DLBCL cases and the potential efficacy of BCR signal inhibitors in treating this aggressive disease are unknown...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28284626/rabbit-hepatitis-e-virus-is-an-opportunistic-pathogen-in-specific-pathogen-free-rabbits-with-the-capability-of-cross-species-transmission
#5
Baoyuan Liu, Yani Sun, Taofeng Du, Yiyang Chen, Xinjie Wang, Baicheng Huang, Huixia Li, Yuchen Nan, Shuqi Xiao, Gaiping Zhang, Julian A Hiscox, En-Min Zhou, Qin Zhao
Hepatitis E virus (HEV) has been detected in rabbits, a recently identified natural reservoir. In this study, anti-HEV antibodies and viral RNA were detected in rabbits sourced from a specific-pathogen-free (SPF) rabbit vendor in Shaanxi Province, China. BLAST results of partial HEV ORF2 genes cloned here indicated that two viral strains circulated in the rabbits. Sequence determination of the complete genome (7302bp) of one strain and a partial ORF1 gene (1537bp) of the other strain showed that they shared 90% identity with one another and 78%-94% identity with other known rabbit HEVs...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28284148/effect-enhancing-and-toxicity-reducing-activity-of-usnic-acid-in-ascitic-tumor-bearing-mice-treated-with-bleomycin
#6
Zu-Qing Su, Yu-Hong Liu, Hui-Zhen Guo, Chao-Yue Sun, Jian-Hui Xie, Yu-Cui Li, Jian-Nan Chen, Xiao-Ping Lai, Zi-Ren Su, Hai-Ming Chen
Usnic acid (UA) can be found in certain lichen species. Growing evidence suggests that UA possesses antitumoral, antioxidative and anti-inflammatory activities. Bleomycin (BLM) is widely used in the treatment of malignant ascites, however, it unexpectedly causes pulmonary fibrosis (PF). Researches show that excessive inflammatory response and oxidative stress in lung tissue is conspicuous causes of BLM-induced PF. Here we investigated mechanism underlying the effect-enhancing and toxicity-reducing activity of UA on H22-bearing mice treated with BLM...
March 8, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28281973/abcb5-zeb1-axis-promotes-invasion-and-metastasis-in-breast-cancer-cells
#7
Juntao Yao, Xuan Yao, Tao Tian, Xiao Fu, Wenjuan Wang, Suoni Li, Tingting Shi, Aili Suo, Zhiping Ruan, Hui Guo, Kejun Nan, Xiongwei Huo
ABCB5 belongs to the ATP-binding cassette (ABC) superfamily, which is recognized for playing a role in the failure of chemotherapy. ABCB5 has also been found to be overexpressed at the transcriptional level in a number of cancer subtypes, including breast cancer. However, the exact mechanism ABCB5 uses on cancer cell metastasis is still unclear. In the present study, we demonstrate that ABCB5 expression was increased in metastatic tissues when compared with nonmetastatic tissues. ABCB5 can significantly enhance metastasis and epithelial-mesenchymal transition (EMT), while knockdown of ABCB5 inhibited these processes...
March 13, 2017: Oncology Research
https://www.readbyqxmd.com/read/28279903/chlorine-inactivation-of-tubifex-tubifex-in-drinking-water-and-the-synergistic-effect-of-sequential-inactivation-with-uv-irradiation-and-chlorine
#8
Xiao-Bao Nie, Zhi-Hong Li, Yuan-Nan Long, Pan-Pan He, Chao Xu
The inactivation of Tubifex tubifex is important to prevent contamination of drinking water. Chlorine is a widely-used disinfectant and the key factor in the inactivation of T. tubifex. This study investigated the inactivation kinetics of chlorine on T. tubifex and the synergistic effect of the sequential use of chlorine and UV irradiation. The experimental results indicated that the Ct (concentration × timereaction) concept could be used to evaluate the inactivation kinetics of T. tubifex with chlorine, thus allowing for the use of a simpler Ct approach for the assessment of T...
February 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/28276316/long-noncoding-rna-meg3-suppresses-glioma-cell-proliferation-migration-and-invasion-by-acting-as-competing-endogenous-rna-of-mir-19a
#9
Gui-Feng Tong, Nan Qin, Li-Wei Sun, Xiao-Lin Xu
Glioma, with varying malignancy grades and histological subtypes, is the commonest primary brain tumor in adults. Longnon-coding RNAs (lncRNAs) are non-protein-coding transcripts and have been proven to play important roles in tumorigenesis. Our study aims to elucidate the combined effect of lncRNA MEG3 and microRNA-19a in human glioma U87 and U251 cell lines. Real time PCR revealed that MEG3 was down-regulated and miR-19a was up-regulated in malignant glioma tissues and cell lines. Bioinformatics analyses (TargetScan, miRanda and starBase V2...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28274118/in-situ-atomic-scale-observation-of-electrochemical-delithiation-induced-structure-evolution-of-licoo2-cathode-in-a-working-all-solid-state-battery
#10
Yue Gong, Jie-Nan Zhang, Liwei Jiang, Jin-An Shi, Qinghua Zhang, Zhenzhong Yang, Dongli Zou, Jiangyong Wang, Xiqian Yu, Ruijuan Xiao, Yong-Sheng Hu, Lin Gu, Hong Li, Liquan Chen
We report a method for in situ atomic-scale observation of electrochemical delithiation in a working all-solid-state battery using a state-of-the-art chip based in-situ TEM holder and focused ion beam milling to prepare an all-solid-state lithium ion battery sample. A battery consisting of LiCoO2 cathode, LLZO solid state electrolyte and gold anode was constructed, delithiated and observed in an aberration corrected scanning transmission electron microscope at atomic scale. We found that the pristine single crystal LiCoO2 became nano-sized poly crystal connected by coherent twin boundaries and antiphase domain boundaries after high voltage delithiation...
March 8, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28272196/transthyretin-related-hereditary-amyloidosis-with-recurrent-vomiting-and-renal-insufficiency-as-the-initial-presentation-a-case-report
#11
Jing Xu, Meng Yang, Xiaoxia Pan, Xialian Yu, Jingyuan Xie, Hong Ren, Xiao Li, Nan Chen
RATIONALE: Hereditary amyloidosis is diagnosed worldwidely with an increasing incidence. As the most common form, transthyretin-related hereditary amyloidosis (ATTR amyloidosis) is an autosomal dominant inherited disease due to mutations of TTR. Over the past several decades, more than 130 mutations have been reported. Previous studies suggested that ATTR amyloidosis initially showed polyneuropathy and autonomic dysfunction but later involving many visceral organs, such as kidney. PATIENT CONCERNS: A young proband carrying TTR p...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28271075/continuous-glucose-monitoring-in-newly-diagnosed-type-2-diabetes-patients-reveals-a-potential-risk-of-hypoglycemia-in-older-men
#12
Feng-Fei Li, Bing-Li Liu, Hong-Hong Zhu, Ting Li, Wen-Li Zhang, Xiao-Fei Su, Jin-Dan Wu, Xue-Qin Wang, Ning Xu, Wei-Nan Yu, Qun Yuan, Guan-Cheng Qi, Lei Ye, Kok-Onn Lee, Jian-Hua Ma
Objectives. We performed continuous glucose monitoring (CGM) to define the features of patients with newly diagnosed type 2 diabetes (T2D) before and after Continuous Subcutaneous Insulin Infusion (CSII) therapy. Methods. This was a retrospective analysis. Newly diagnosed T2D patients (106) were admitted from eight centers in China. They were divided into a younger patient group (<60 years) and an older patient group (≥60 years). Each group was further divided into male and female patients. CSII therapy was maintained for 3 weeks after the glycemic target was reached...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/28267797/correction-nur77-deficiency-in-mice-accelerates-tumor-invasion-and-metastasis-by-facilitating-tnf%C3%AE-secretion-and-lowering-csf-1r-expression
#13
Xiu-Ming Li, Jing-Ru Wang, Tong Shen, Shang-Shang Gao, Xiao-Shun He, Jiang-Nan Li, Tian-Yu Yang, Shen Zhang, Wen-Juan Gan, Jian-Ming Li, Hua Wu
[This corrects the article DOI: 10.1371/journal.pone.0171347.].
2017: PloS One
https://www.readbyqxmd.com/read/28266619/plasmon-modulated-excitation-dependent-fluorescence-from-activated-ctab-molecules-strongly-coupled-to-gold-nanoparticles
#14
Si-Jing Ding, Fan Nan, Xiao-Li Liu, Zhong-Hua Hao, Li Zhou, Jie Zeng, Hong-Xing Xu, Wei Zhang, Qu-Quan Wang
Excitation-dependent fluorophores (EDFs) have been attracted increasing attention owing to their high tunability of emissions and prospective applications ranging from multicolor patterning to bio-imaging. Here, we report tunable fluorescence with quenching dip induced by strong coupling of exciton and plasmon in the hybrid nanostructure of CTAB* EDFs and gold nanoparticles (AuNPs). The quenching dip in the fluorescence spectrum is tuned by adjusting excitation wavelength as well as plasmon resonance and concentration of AuNPs...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28266596/bioinformatics-analysis-of-the-proteins-interacting-with-lasp-1-and-their-association-with-hbv-related-hepatocellular-carcinoma
#15
Fan-Yun Kong, Ting Zhu, Nan Li, Yun-Fei Cai, Kai Zhou, Xiao Wei, Yan-Bo Kou, Hong-Juan You, Kui-Yang Zheng, Ren-Xian Tang
LIM and SH3 domain protein (LASP-1) is responsible for the development of several types of human cancers via the interaction with other proteins; however, the precise biological functions of proteins interacting with LASP-1 are not fully clarified. Although the role of LASP-1 in hepatocarcinogenesis has been reported, the implication of LASP-1 interactors in HBV-related hepatocellular carcinoma (HCC) is not clearly evaluated. We obtained information regarding LASP-1 interactors from public databases and published studies...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28265099/neonatal-cx26-removal-impairs-neocortical-development-and-leads-to-elevated-anxiety
#16
Xin Su, Jing-Jing Chen, Lin-Yun Liu, Qian Huang, Li-Zhao Zhang, Xiao-Yang Li, Xiang-Nan He, Wenlian Lu, Shan Sun, Huawei Li, Yong-Chun Yu
Electrical coupling between excitatory neurons in the neocortex is developmentally regulated. It is initially prominent but eliminated at later developmental stages when chemical synapses emerge. However, it remains largely unclear whether early electrical coupling networks broadly contribute to neocortical circuit formation and animal behavior. Here, we report that neonatal electrical coupling between neocortical excitatory neurons is critical for proper neuronal development, synapse formation, and animal behavior...
March 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28260102/long-non-coding-rna-malat1-interacts-with-mir-124-and-modulates-tongue-cancer-growth-by-targeting-jag1
#17
Tong-Han Zhang, Li-Zhong Liang, Xiao-Ling Liu, Ji-Nan Wu, Kui Su, Jue-Yao Chen, Qiao-Yi Zheng, Hong-Zhang Huang, Gui-Qing Liao
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), was the earliest discovered to be correlated with cancer and contributes to the initiation and development of several types of tumors. Dysregulation of MALAT1 expression is frequently observed in many types of cancer such as gastric cancer, esophageal squamous cell carcinoma and glioma. To date, the role of MALAT1 and the underlying mechanisms in tongue cancer development remain unclear. In the present study, we studied the influence of MALAT1 on tongue cancer cell lines and clinical tongue cancer samples so as to detect its function and the underlying mechanism...
February 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28256577/copper-catalyzed-direct-2-arylation-of-benzoxazoles-and-benzoimidazoles-with-aryl-bromides-and-cytotoxicity-of-products
#18
Nan-Nan Jia, Xin-Chuan Tian, Xiao-Xia Qu, Xing-Xiu Chen, Ya-Nan Cao, Yun-Xin Yao, Feng Gao, Xian-Li Zhou
An efficient copper-catalyzed direct 2-arylation of benzoxazoles and benzoimidazoles with aryl bromides is presented. The CuI/PPh3-based catalyst promotes the installation of various aryl and heteroaryl groups through a C-H activation process in good to excellent yields. The cytotoxicity of obtained 2-aryl benzoxazoles (benzoimidazoles) was also evaluated and 1-methyl-2-(naphthalen-1-yl)benzoimidazole showed potential cytotoxicity.
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28256122/bufospirostenin-a-and-bufogargarizin-c-steroids-with-rearranged-skeletons-from-the-toad-bufo-bufo-gargarizans
#19
Hai-Yan Tian, Li-Jun Ruan, Tong Yu, Qing-Fei Zheng, Nan-Hao Chen, Rui-Bo Wu, Xiao-Qi Zhang, Lei Wang, Ren-Wang Jiang, Wen-Cai Ye
Bufospirostenin A (1) and bufogargarizin C (2), two novel steroids with rearranged A/B rings, were isolated from the toad Bufo bufo gargarizans. Compound 1 represents the first spirostanol found in animals. Compound 2 is an unusual bufadienolide with a cycloheptatriene B ring. Their structures were elucidated by spectroscopic analysis, single crystal X-ray diffraction analysis, and computational calculations.
March 3, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28250067/the-mitochondrial-protease-ftsh4-regulates-leaf-senescence-via-wrky-dependent-salicylic-acid-signal
#20
Shengchun Zhang, Cui Li, Rui Wang, Yaxue Chen, Si Shu, Ruihua Huang, Daowei Zhang, Shi Xiao, Nan Yao, Jian Li, Chengwei Yang
Mitochondria and autophagy play important roles in the networks that regulate plant leaf senescence and cell death. However, the molecular mechanisms underlying the interactions between mitochondrial signaling and autophagy are currently not well understood. This study characterized the function of the Arabidopsis mitochondrial AAA-protease gene AtFtSH4 in regulating autophagy and senescence,finding that AtFtSH4 mediates WRKY-dependent salicylic acid (SA) accumulation and signaling. Knock-out of FtSH4 in the ftsh4-4 mutant resulted in severe leaf senescence, cell death, and high autophagy levels...
March 1, 2017: Plant Physiology
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