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Xiao-Nan Li

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https://www.readbyqxmd.com/read/29777796/identification-of-a-sodium-pump-na-k-atpase-%C3%AE-1-targeted-peptide-for-pet-imaging-of-breast-cancer
#1
Qian Wang, Shi-Bing Li, Yi-Ying Zhao, Da-Nian Dai, Hui Du, Yan-Zhu Lin, Jia-Cong Ye, Jing Zhao, Wei Xiao, Yan Mei, Yi-Tai Xiao, Shi-Chu Liu, Yan Li, Yun-Fei Xia, Er-Wei Song, Gang-Hua Tang, Wei-Guang Zhang, Zhi-Jiang Li, Xiao-Bin Zheng, De-Hai Cao, Man-Zhi Li, Qian Zhong, Zhong-Ping Chen, Chao-Nan Qian, Wei Fan, Guo-Kai Feng, Mu-Sheng Zeng
The sodium pump Na+ /K+ ATPase a1 subunit(NKA a1), an attractive cancer-related biomarker and therapeutic target, is closely related to the development and progression of several cancers including breast cancer. Currently, a NKA a1 inhibitor, UNBS1450, has already evidenced its great therapeutic potential in personalized cancer treatment. The ability of non-invasive imaging of NKA a1 expression would be useful for selecting cancer patients who may benefit from this drug. Here, we identified an S3 peptide that is specifically homed to breast cancer by phage display...
May 16, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29770653/-study-on-role-of-tigit-signal-in-th1-th2-balance-in-schistosoma-japonicum-infected-mice
#2
Zhang Li-Na, Wang Xiao-Fan, Qi Qian-Qian, Dong Li-Yang, Xu Lei, Pu Ya-Nan, Wei Chuan, Zhu Ji-Feng, Zhou Sha, Li Ya-Lin, Liu Feng, Chen Xiao-Jun, Su Chuan
OBJECTIVE: To investigate the role of TIGIT signal in Th1/Th2 balance in the process of Schistosoma japonicum infection. METHODS: Male C57BL/6 mice were infected with cercariae of S. japonicum , and normal uninfected mice served as the controls. The percentages of TIGIT+ cells, Ki67+ CD3+ CD4+ TIGIT+ cells, Ki67+ CD3+ CD4+ TIGIT- cells, IFN-γ+ CD3+ CD4+ TIGIT+ cells, IFN-γ+ CD3+ CD4+ TIGIT- cells, IL-4+ CD3+ CD4+ TIGIT+ cells and IL-4+ CD3+ CD4+ TIGIT- cells were evaluated in mouse spleen by flow cytometry...
April 20, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29770652/-effects-of-glycolytic-pathway-on-generation-of-regulatory-t-cells-during-schistosoma-japonicum-infection
#3
Wang Xiao-Fan, Qi Qian-Qian, Zhang Li-Na, Xu Lei, Dong Li-Yang, Li Ya-Lin, Pu Ya-Nan, Wei Chuan, Zhou Sha, Zhu Ji-Feng, Chen Xiao-Jun, Su Chuan
OBJECTIVE: To assess the influence of glycolytic pathway on the proportion and numbers of regulatory T cells during Schistosoma japonicum infection. METHODS: A S. japonicum -infected mouse model was established, and C57/BL6 male mice infected with S. japonicum were subjected to intraperitoneal injections of with the glycolytic inhibitor 2-Deoxy-D-glucose (2DG) or PBS for 6 times, and then the cells from spleen or mesenteric lymph nodes (LNs) were isolated and analyzed by flow cytometry (FCM) to detect the percentage of Glut1+ CD4+ T cells and Treg cells...
April 20, 2018: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29769119/adefovir-dipivoxil-induced-hypophosphatemic-osteomalacia-in-chronic-hepatitis-b-a-comparative-study-of-chinese-and-foreign-case-series
#4
Nan Chen, Jian-Bo Zhang, Qiujie Zhang, Yun-Peng Zhao, Li-Yan Li, Li-Wei Liu, Fei Yu, Xin Yu, Tao Peng, Kuan-Xiao Tang
BACKGROUND: Adefovir dipivoxil (ADV)-induced renal tubular dysfunction and hypophosphatemic osteomalacia (HO) have been given great consideration in the past few years. However, no standard guidance is available due to a lack of powerful evidence from appropriate long-term prospective case-control studies and variations in the definition of renal adverse events. The aim of this study is to clarify clinical features of ADV-related HO in Chinese chronic hepatitis B patients with long-term ADV treatment in Chinese and non-Chinese comparative case series...
May 16, 2018: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29761860/hypermethylation-of-cpg-islands-is-associated-with-increasing-chromosomal-damage-in-chinese-lead-exposed-workers
#5
Li-Bo Yu, Yu-Ting Tu, Jing-Wen Huang, Ya-Nan Zhang, Guo-Qiao Zheng, Xiao-Wen Xu, Jin-Wei Wang, Jean Qin Xiao, David C Christiani, Zhao-Lin Xia
Lead is a widely existing environmental pollutant with potential carcinogenicity. To investigate the association of blood lead level (B-Pb) with potential chromosomal damage and cancer, we analyzed micronucleus (MN) frequency of peripheral blood lymphocytes (PBLs) and the methylation status of six human tumor suppressor genes (TSGs) post lead exposure. In the study, 147 lead-exposed workers were divided into two groups according to their B-Pb P50 value, with other 50 lead-unexposed workers as a control group...
May 15, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29761241/glucocorticoids-in-the-treatment-of-patients-with-primary-focal-segmental-glomerulosclerosis-and-moderate-proteinuria
#6
Jianni Huang, Li Lin, Jingyuan Xie, Xiao Li, Pingyan Shen, Xiaoxia Pan, Hong Ren, Nan Chen
BACKGROUND: To compare the efficacy of glucocorticoids in primary focal segmental glomerulosclerosis (pFSGS) patients with moderate proteinuria. Registered at http://www.chictr.org.cn/ , study No. ChiCTR-OPN-17012789. METHODS: pFSGS patients with urine protein between 1.0 and 3.5 g/24 h were recruited from 2006 to 2016. No decline in urine protein > 50% was observed after 2 months of run-in angiotensin-converting enzyme inhibitors/angiotensin-receptor blockers (ACEI/ARB) treatment...
May 14, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29760297/follicular-hyperandrogenism-and-insulin-resistance-in-polycystic-ovary-syndrome-patients-with-normal-circulating-testosterone-levels
#7
Andi Li, Lu Zhang, Jiajia Jiang, Nan Yang, Ying Liu, Lingbo Cai, Yugui Cui, Feiyang Diao, Xiao Han, Jiayin Liu, Yujie Sun
Polycystic ovary syndrome (PCOS) is a common reproductive disease with high heterogeneity. The role of excess androgen in PCOS etiology remains disputed, since around 20%-50% of PCOS women do not display hyperandrogenemia. The microenvironment of the ovary critically influences follicular development. In the present study, we assessed the role of androgen in PCOS by investigating whether excessive follicular fluid androgen was present in PCOS patients with normal serum androgen levels and influenced by follicular fluid insulin resistance (IR)...
November 1, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/29756515/effects-of-polaprezinc-on-gastric-mucosal-damage-and-neurotransmitters-in-a-rat-model-of-chemotherapy-induced-vomiting
#8
Zhao Yang Liu, Wen Bo Xie, Ming Ru Li, Nan Teng, Xiao Liang, Zi Qiang Zhang
Objective To investigate the effects of polaprezinc (PZ) on cyclophosphamide (CTX)- or cisplatin (DDP)-induced gastric mucosal injury and on a rat model of neurotransmitter-mediated vomiting. Methods Sprague-Dawley rats were divided at random into Control, CTX, DDP, PZ+CTX, and PZ+DDP groups. After 20 days, brain tissues and sera were analyzed for the levels of dopamine (DA), 5-hydroxytryptamine (5-HT), and nuclear factor kappa B (NF-κB). Hematoxylin and eosin-stained sections of stomach, intestine, and brain tissues were examined using light microscopy...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29751721/-analysis-of-adverse-reactions-factors-to-danhong-injection-nested-case-control-study-by-using-hospital-centralized-monitoring-data
#9
Meng-Meng Ji, Chun-Xiao Li, Jin-Fa Tang, Qing-Li Zhang, Tao Xu, Ya-Nan Yu, Jun Liu, Wei Yang, Wei-Bin Yang, Zhong Wang, Zhi-Wei Jing, Xue-Lin Li
To study the adverse reactions' factors to Danhong injection in the real world. A multi-center, large sample and prospective hospital centralized monitoring method was adopted, and 30 888 cases of Danhong injection from 37 national 3A hospitals were collected to carry out a nested case control design study. These cases were divided into adverse reaction group and non-adverse group. Single factor logistic regression and multiple factor logistic regression were used to analyze data, and investigate the correlation between adverse reaction and gender, allergy history, methods of administration, and combined drug use...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29750927/frozen-elephant-trunk-for-acute-type-b-dissection-involving-the-distal-arch-in-the-hybrid-repair-era
#10
Rui-Dong Qi, Jun-Ming Zhu, Yong-Min Liu, Lei Chen, Cheng-Nan Li, Xiao-Yan Xing, Nan Zhang, Li-Zhong Sun
BACKGROUND: Hybrid repair of complicated acute type B aortic dissection(ATBAD) with aortic arch involvement is associated with a high rate of endoleak, stroke, and retrograde aortic dissection. Optimal management of this lesion remains uncertain. In this hybrid repair era, surgical results of ATBAD with distal aortic arch involvement using a frozen elephant trunk(FET) procedure with left subclavian artery(LSCA)-left common carotid artery(LCCA) transposition is reported. METHODS: From April 2011 to April 2016, 53 patients with complicated ATBAD with distal aortic arch involvement underwent a FET procedure with LSCA-LCCA transposition...
May 8, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29750271/ape1-deficiency-promotes-cellular-senescence-and-premature-aging-features
#11
Mengxia Li, Xiao Yang, Xianfeng Lu, Nan Dai, Shiheng Zhang, Yi Cheng, Lei Zhang, Yuxin Yang, Yie Liu, Zhenzhou Yang, Dong Wang, David M Wilson
Base excision repair (BER) handles many forms of endogenous DNA damage, and apurinic/apyrimidinic endonuclease 1 (APE1) is central to this process. Deletion of both alleles of APE1 (a.k.a. Apex1) in mice leads to embryonic lethality, and deficiency in cells can promote cell death. Unlike most other BER proteins, APE1 expression is inversely correlated with cellular senescence in primary human fibroblasts. Depletion of APE1 via shRNA induced senescence in normal human BJ fibroblasts, a phenotype that was not seen in counterpart cells expressing telomerase...
May 10, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29749456/role-of-the-overexpression-of-traf4-in-predictingthe-prognosis-of-intrahepatic-cholangiocarcinoma
#12
Qiang Kang, Hao Zou, Lei Zhou, Li-Xin Liu, Jia-Bin Cai, Nan Xie, Wei-Hao Li, Chao Zhang, Wan-Hong Shi, Lian-Min Wang, Wei-Han Zhang, Hong Zhu, Shu-Fen Wang, Xiao-Wen Zhang
The incidence of intrahepatic cholangiocarcinoma (ICC) is progressively increasing worldwide, and its prognosis remains poor. Accumulating evidence has demonstrated that tumor necrosis factor receptor-associated factor 4 (TRAF4), an adaptor protein, is involved in the carcinogenesis and progression of several tumor types. However, the function of TRAF4 in predicting prognosis, and mediating migration and invasion of ICC remains to be elucidated. In the present study, immunohistochemistry, western blotting and reverse transcription-quantitative polymerase chain reaction assays were used to determine that the expression of TRAF4 at the mRNA and protein levels in ICC tissues was significantly higher compared with that in non‑tumor tissues...
April 26, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29748051/discovery-of-3-s-thiomethyl-pyrrolidine-erk-inhibitors-for-oncology
#13
Sobhana Babu Boga, Abdul-Basit Alhassan, Alan B Cooper, Ronald Doll, Neng-Yang Shih, Gerald Shipps, Yongqi Deng, Hugh Zhu, Yang Nan, Robert Sun, Liang Zhu, Jagdish Desai, Mehul Patel, Kiran Muppalla, Xiaolei Gao, James Wang, Xin Yao, Joseph Kelly, Subrahmanyam Gudipati, Sunil Paliwal, Hon-Chung Tsui, Tong Wang, Bradley Sherborne, Li Xiao, Alan Hruza, Alexei Buevich, Li-Kang Zhang, David Hesk, Ahmed A Samatar, Donna Carr, Brian Long, Stuart Black, Priya Dayananth, William Windsor, Paul Kirschmeier, Robert Bishop
Compound 5 (SCH772984) was identified as a potent inhibitor of ERK1/2 with excellent selectivity against a panel of kinases (0/231 kinases tested @ 100 nM) and good cell proliferation activity, but suffered from poor PK (rat AUC PK @10 mpk = 0 μM h; F% = 0) which precluded further development. In an effort to identify novel ERK inhibitors with improved PK properties with respect to 5, a systematic exploration of sterics and composition at the 3-position of the pyrrolidine led to the discovery of a novel 3(S)-thiomethyl pyrrolidine analog 28 with vastly improved PK (rat AUC PK @10 mpk = 26 μM h; F% = 70)...
April 26, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29745201/-distribution-of-soil-organic-carbon-total-nitrogen-total-phosphorus-and-water-stable-aggregates-of-cropland-with-different-soil-textures-on-the-loess-plateau-northwest-china
#14
Nan Nan Ge, Yun Shi, Xian Long Yang, Qing Yin Zhang, Xue Zhang Li, Xiao Xu Jia, Ming An Shao, Xiao Rong Wei
In this study, combined with field investigation and laboratory analyses, we assessed the distribution of soil organic carbon, nitrogen, phosphorous contents and their stoichiometric ratios, and the distribution of soil water stable aggregates along a soil texture gradient in the cropland of the Loess Plateau to understand the effect of soil texture and the regulation of soil aggregates on soil fertility in cropland. The results showed that, with the change from fine soils to coarse soils along the texture gradient (loam clay→ clay loam→ sandy loam), the contents of macroaggregates, organic carbon, nitrogen, phosphorous and their stoichiometric ratios decreased, while pH value and microaggregates content showed an opposite changing pattern...
May 18, 2017: Ying Yong Sheng Tai Xue Bao, the Journal of Applied Ecology
https://www.readbyqxmd.com/read/29740358/the-comorbidity-between-internet-gaming-disorder-and-depression-interrelationship-and-neural-mechanisms
#15
Lu Liu, Yuan-Wei Yao, Chiang-Shan R Li, Jin-Tao Zhang, Cui-Cui Xia, Jing Lan, Shan-Shan Ma, Nan Zhou, Xiao-Yi Fang
Internet gaming disorder (IGD) is characterized by cognitive and emotional deficits. Previous studies have reported the co-occurrence of IGD and depression. However, extant brain imaging research has largely focused on cognitive deficits in IGD. Few studies have addressed the comorbidity between IGD and depression symptoms and underlying neural mechanisms. Here, we systematically investigated this issue by combining a longitudinal survey study, a cross-sectional resting-state functional connectivity (rsFC) study and an intervention study...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29740343/identification-of-chemosensory-genes-based-on-the-transcriptomic-analysis-of-six-different-chemosensory-organs-in-spodoptera-exigua
#16
Ya-Nan Zhang, Jia-Li Qian, Ji-Wei Xu, Xiu-Yun Zhu, Meng-Ya Li, Xiao-Xue Xu, Chun-Xiang Liu, Tao Xue, Liang Sun
Insects have a complex chemosensory system that accurately perceives external chemicals and plays a pivotal role in many insect life activities. Thus, the study of the chemosensory mechanism has become an important research topic in entomology. Spodoptera exigua Hübner (Lepidoptera: Noctuidae) is a major agricultural polyphagous pest that causes significant agricultural economic losses worldwide. However, except for a few genes that have been discovered, its olfactory and gustatory mechanisms remain uncertain...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29739712/radiotherapy-is-essential-after-complete-response-to-asparaginase-containing-chemotherapy-in-early-stage-extranodal-nasal-type-nk-t-cell-lymphoma-a-multicenter-study-from-the-china-lymphoma-collaborative-group-clcg
#17
Xiu-Wen Deng, Jun-Xin Wu, Tao Wu, Su-Yu Zhu, Mei Shi, Hang Su, Ying Wang, Xia He, Li-Ming Xu, Zhi-Yong Yuan, Li-Ling Zhang, Gang Wu, Bao-Lin Qu, Li-Ting Qian, Xiao-Rong Hou, Fu-Quan Zhang, Yu-Jing Zhang, Yuan Zhu, Jian-Zhong Cao, Sheng-Min Lan, Mei Dong, Shu-Nan Qi, Yong Yang, Ye-Xiong Li
PURPOSE: This study aimed to clarify the benefit of radiotherapy (RT) in patients with early-stage extranodal NK/T-cell lymphoma (NKTCL) who achieve a complete response (CR) after asparaginase-containing chemotherapy (CT). PATIENTS AND METHODS: Of 240 patients achieved a CR after asparaginase-containing CT, 202 patients received additional RT (CT + RT), and 38 patients did not (CT alone). RESULTS: Compared to CT alone, CT + RT significantly improved overall survival (OS), disease-free survival (DFS) and locoregional control (LRC)...
May 5, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29739602/characteristic-antioxidant-activity-and-comprehensive-flavor-compound-profile-of-scallop-chlamys-farreri-mantle-hydrolysates-ribose-maillard-reaction-products
#18
Jia-Run Han, Jia-Nan Yan, Shi-Guang Sun, Yue Tang, Wen-Hui Shang, Ao-Ting Li, Xiao-Kun Guo, Yi-Nan Du, Hai-Tao Wu, Bei-Wei Zhu, Youling L Xiong
The objective of the present study was to improve the utilization of scallop (Chlamys farreri) byproducts by using Maillard reaction. Scallop mantle hydrolysates (SMHs) were prepared using neutrase then reacted with ribose. Thirty-four peptides were identified from SMHs by UPLC-Q-TOF-MS, and the abundance of Asp and Lys suggested the strong Maillard reactivity. The formation of Schiff's base as well as modification of amide I, II and III bands in Maillard reaction products (MRPs) was confirmed by ultraviolet-visible, fluorescence, and Fourier transform infrared spectroscopy...
September 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29736132/the-level-of-nesfatin-1-in-a-mouse-gastric-cancer-model-and-its-role-in-gastric-cancer-comorbid-with-depression
#19
Nan Zhang, Jiangbo Li, Huiling Wang, Ling Xiao, Yanyan Wei, Jing He, Gaohua Wang
Background: The incidence of depressive symptoms is higher in cancer patients. And depression can also affect the occurrence, development and outcome of cancer through the neuroendocrine-immune-network system. Objective: To study the level of Nesfatin-1 in the plasma and brain tissue and its role in the pathogenesis in gastric cancer comorbid with depression using a mouse gastric cancer model. Methods: 18 mice were randomly divided into the normal control group (NCG), gastric cancer without stress model group (GCNS), and gastric cancer combined with stress model group (GCS)...
April 25, 2018: Shanghai Archives of Psychiatry
https://www.readbyqxmd.com/read/29735918/soy-protein-isolate-phosphatidylcholine-nanoemulsions-prepared-using-high-pressure-homogenization
#20
Yang Li, Chang-Ling Wu, Jun Liu, Ying Zhu, Xiao-Yuan Zhang, Lian-Zhou Jiang, Bao-Kun Qi, Xiao-Nan Zhang, Zhong-Jiang Wang, Fei Teng
The nanoemulsions of soy protein isolate-phosphatidylcholine (SPI-PC) with different emulsion conditions were studied. Homogenization pressure and homogenization cycle times were varied, along with SPI and PC concentration. Evaluations included turbidity, particle size, ζ-potential, particle distribution index, and turbiscan stability index (TSI). The nanoemulsions had the best stability when SPI was at 1.5%, PC was at 0.22%, the homogenization pressure was 100 MPa and homogenization was performed 4 times...
May 7, 2018: Nanomaterials
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