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Xiao-Nan Li

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https://www.readbyqxmd.com/read/28528333/effect-of-1-25-oh-2d3-on-proliferation-of-fibroblast-like-synoviocytes-and-expressions-of-pro-inflammatory-cytokines-through-regulating-microrna-22-in-a-rat-model-of-rheumatoid-arthritis
#1
Ping Fan, Lan He, Nan Hu, Jing Luo, Jing Zhang, Ling-Fei Mo, Yan-Hua Wang, Dan Pu, Xiao-Hong Lv, Zhi-Ming Hao, Chang-Hai Ding, Wu-Jun Xue, Yang Li
OBJECTIVE: This study aims to investigate the regulatory mechanism of 1,25-(OH)2D3 on the proliferation of fibroblast-like synoviocytes (FLS) and expressions of pro-inflammatory cytokines in rheumatoid arthritis (RA) rats via microRNA-22 (miR-22). METHODS: A rat model of RA was established with a subcutaneous injection of type II collagen. After treated with different concentrations of 1,25-(OH)2D3 the proliferation of FLS was estimated by the MTT method, and the optimal concentration of 1,25-(OH)2D3 was selected for further experiments...
May 12, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28526071/retinoid-acid-induced-microrna-31-5p-suppresses-myogenic-proliferation-and-differentiation-by-targeting-camkii%C3%AE
#2
Bo Liu, Chao Liu, Wei Cong, Nan Li, Nan Zhou, Yi Tang, Chao Wei, Han Bai, Ying Zhang, Jing Xiao
BACKGROUND: We previously reported that Wnt5a/CaMKIIδ (calcium/calmodulin-dependent protein kinase II delta) pathway was involved in the embryonic tongue deformity induced by excess retinoic acid (RA). Our latest study found that the expression of miR-31-5p, which was predicted to target the 3'UTR of CamkIIδ, was raised in the RA-treated embryonic tongue. Thus, we hypothesized that the excess RA regulated Wnt5a/CaMKIIδ pathway through miR-31-5p in embryonic tongue. METHODS: C2C12 myoblast line was employed as an in vitro model to examine the suppression of miR-31-5p on CamkIIδ expression, through which RA impaired the myoblast proliferation and differentiation in embryonic tongue...
May 11, 2017: Skeletal Muscle
https://www.readbyqxmd.com/read/28521825/association-of-4p14-and-6q27-variation-with-graves-disease-a-case-control-study-and-a-meta-analysis-of-available-evidence
#3
Fa-Mei Li, Lin Liu, Li-Nan Pang, Min Shen, Hong-Wen Lu, Xiao-Hong Zhang, Xun Chu, Zhen-Ju Song
BACKGROUND: The etiology of the Graves' disease (GD) is largely unknown. However, genetic factors are believed to play a major role. A recent genome-wide association study in a Han Chinese sample collection revealed two new Graves' disease (GD) risk loci within chromosome band 4p14 and 6q27. In this study, we aimed to investigate these associations with Weifang Han Chinese population of Shandong province and perform a meta-analysis of associations with GD. METHODS: A case-control study was conducted to investigate association of variation within 4p14 and 6q27 to GD susceptibility in Weifang Han Chinese population of Shandong province...
May 18, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28514724/sirna-mediated-inactivation-of-her3-improves-the-antitumour-activity-and-sensitivity-of-gefitinib-in-gastric-cancer-cells
#4
Heng-Heng Yuan, Ying-Nan Yang, Jian-Hua Zhou, Yan-Jing Li, Li-Ying Wang, Jun-Wei Qin, Tao Liu, Zhen-Zhen Li, Qing-Xin Zhou, Xiao-Li Wei, Ting-Ting Zhang, Peng Huang, Wen-Jie Zhang, Lei Liu, Xiao-Xue Du, Yu Han
The human EGFR family consists of four type-1 transmembrane tyrosine kinase receptors: HER1 (EGFR, ErbB1), HER2 (Neu, ErbB2), HER3 (ErbB3), and HER4 (ErbB4). HER3 can dimerize with EGFR, HER2 and even c-Met and likely plays a central role in the response to EGFR-targeted therapy. Because HER3 lacks significant kinase activity and cannot be inhibited by tyrosine kinase inhibitors, neutralizing antibodies and alternative inhibitors of HER3 have been sought as cancer therapeutics. Here, we describe the stable suppression of HER3 mRNA and protein using siRNA...
April 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28505136/gubenyiliu-ii-inhibits-breast-tumor-growth-and-metastasis-associated-with-decreased-heparanase-expression-and-phosphorylation-of-erk-and-akt-pathways
#5
Yi Zhang, Gan-Lin Zhang, Xu Sun, Ke-Xin Cao, Ya-Wen Shang, Mu-Xin Gong, Cong Ma, Nan Nan, Jin-Ping Li, Ming-Wei Yu, Guo-Wang Yang, Xiao-Min Wang
Gubenyiliu II (GYII), a Traditional Chinese Medicine (TCM) formula used in our hospital, has shown beneficial effects in cancer patients. In this study, we investigated the molecular mechanisms underlying the beneficial effects of GYII on murine breast cancer models. GYII showed significant inhibitory effects on tumor growth and metastasis in the murine breast cancer model. Additionally, GYII suppressed the proliferation of 4T1 and MCF-7 cells in a dose-dependent manner. A better inhibitory effect on 4T1 cell proliferation and migration was found in the decomposed recipes (DR) of GYII...
May 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28498503/p62-sqstm1-as-an-oncotarget-mediates-cisplatin-resistance-through-activating-rip1-nf-%C3%AE%C2%BAb-pathway-in-human-ovarian-cancer-cells
#6
Xiao-Yu Yan, Yu Zhang, Juan-Juan Zhang, Li-Chao Zhang, Ya-Nan Liu, Yao Wu, Ya-Nan Xue, Sheng-Yao Lu, Jing Su, Lian-Kun Sun
Platinum-based therapeutic strategies have been widely used in ovarian cancer treatment. However, drug resistance has greatly limited therapeutic efficacy. Recently, tolerance to cisplatin has been attributed to other factors unrelated to DNA. p62 (also known as SQSTM1) functions as a multifunctional hub participating in tumorigenesis and may be a therapeutic target. Our previous study showed that p62 was overexpressed in drug-resistant ovarian epithelial carcinoma and its inhibition increased the sensitivity to cisplatin...
May 12, 2017: Cancer Science
https://www.readbyqxmd.com/read/28494305/photovoltage-response-of-xzn-fe2o4-bifeo3-x-mg-mn-or-ni-interfaces-for-highly-selective-cr-3-cd-2-co-2-and-pb-2-ions-detection
#7
Liang Bian, Yu-Jin Li, Jing Li, Jia-Nan Nie, Fa-Qin Dong, Mian-Xin Song, Li-Sheng Wang, Hai-Liang Dong, Hai-Long Li, Xiao-Qin Nie, Xiao-Yan Zhang, Xin-Xi Li, Lei Xie
High-photostability fluorescent (XZn)Fe2O4 (X=Mg, Mn or Ni) embedded in BiFeO3 spinel-perovskite nanocomposites were successfully fabricated via a novel bio-induced phase transfer method using shewanella oneidensis MR-1. These nanocomposites have the near-infrared fluorescence response (XZn or Fe)-O-O-(Bi) interfaces (785/832nm), and the (XZn)Fe2O4/BiFeO3 lattices with high/low potentials (572.15-808.77meV/206.43-548.1meV). Our results suggest that heavy metal ion (Cr(3+), Cd(2+), Co(2+) and Pb(2+)) d↓ orbitals hybridize with the paired-spin X-Zn-Fe d↓-d↓-d↑↓ orbitals to decrease the average polarization angles (-29...
May 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28492138/long-noncoding-rna-schlap1-accelerates-the-proliferation-and-metastasis-of-prostate-cancer-via-targeting-mir-198-and-promoting-the-mapk1-pathway
#8
Ye Li, Haihong Luo, Nan Xiao, Jianmin Duan, Zhiping Wang, Shuanke Wang
Prostate cancer has become the most commonly diagnosed and the second leading cause of cancer-related deaths in males.The long non-coding RNA SChLAP1 (second chromosome locus associated with prostate-1) has been found overexpressed in a subset of prostate cancers; however the significance and mechanism of SChLAP1 in prostate cancer is not well-known. In this study we explored the role of SChLAP1 in prostate cancer tissues, cell lines and mouse models. The effects of SChLAP1 on miR-198 and MAPK1 were specifically examined...
May 11, 2017: Oncology Research
https://www.readbyqxmd.com/read/28485054/egfr-gene-mutation-in-gastrointestinal-stromal-tumors
#9
Shan-Shan Shi, Nan Wu, Yan He, Xue Wei, Qiu-Yuan Xia, Xuan Wang, Sheng-Bin Ye, Rui Li, Qiu Rao, Xiao-Jun Zhou
AIMS: The aim of this study was to evaluate the mutation status of EGFR in gastrointestinal stromal tumours and its association with various clinicopathological variables as well as to further discuss its effects of EGFR mutations on tumor formation and progression. METHODS: A well-characterized cohort of 323 GISTs, obtained between 2010 and 2015 from the surgical pathology files of at the Department of Pathology of the Nanjing Jinling Hospital, was screened for mutations in exon 19 and 21 of the EGFR gene...
May 9, 2017: Histopathology
https://www.readbyqxmd.com/read/28476445/characteristic-patterns-of-normal-meridian-acupoint-temperature
#10
Han-Ning Wei, Li-Ping Jiang, Bin Xiong, Si Zhou, Lan Yu, Yan-Mei Huang, Dao-Guang Liu, Wei Ling, Xin-Nan Song, Xiao-Xi Zhang, Hai-Lu Zhao
BACKGROUND: Body temperature is an important indicator of health and illness. However, a single temperature measurement is not always reliable. Such measurements can be made using meridians, which are energy channels with acupoints being the nodes. To date, there is no published reference of meridian acupoint temperatures applicable to human health, and there is no clear digitalized indicator that could be utilized to evaluate human health by way of meridian acupoints up to now. METHODS: Our study recruited 100 healthy medical college students for the measurement of acupoint temperature...
May 2, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28470188/rgc32-induces-epithelial-mesenchymal-transition-by-activating-the-smad-sip1-signaling-pathway-in-crc
#11
Xiao-Yan Wang, Sheng-Nan Li, Hui-Fang Zhu, Zhi-Yan Hu, Yan Zhong, Chuan-Sha Gu, Shi-You Chen, Teng-Fei Liu, Zu-Guo Li
Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC32 in tumorigenesis and tumor progression in colorectal cancer (CRC) has not been fully elucidated. Here, we showed that the expression of RGC32 was significantly up-regulated in human CRC tissues versus adjacent normal tissues. RGC32 expression was significantly correlated with invasive and aggressive characteristics of tumor cells, as well as poor survival of CRC patients...
May 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28469625/light-induced-variation-in-phenolic-compounds-in-cabernet-sauvignon-grapes-vitis-vinifera-l-involves-extensive-transcriptome-reprogramming-of-biosynthetic-enzymes-transcription-factors-and-phytohormonal-regulators
#12
Run-Ze Sun, Guo Cheng, Qiang Li, Yan-Nan He, Yu Wang, Yi-Bin Lan, Si-Yu Li, Yan-Rong Zhu, Wen-Feng Song, Xue Zhang, Xiao-Di Cui, Wu Chen, Jun Wang
Light environments have long been known to influence grape (Vitis vinifera L.) berry development and biosynthesis of phenolic compounds, and ultimately affect wine quality. Here, the accumulation and compositional changes of hydroxycinnamic acids (HCAs) and flavonoids, as well as global gene expression were analyzed in Cabernet Sauvignon grape berries under sunlight exposure treatments at different phenological stages. Sunlight exposure did not consistently affect the accumulation of berry skin flavan-3-ol or anthocyanin among different seasons due to climatic variations, but increased HCA content significantly at véraison and harvest, and enhanced flavonol accumulation dramatically with its timing and severity degree trend...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28469109/comparison-of-composition-and-diversity-of-bacterial-microbiome-in-human-upper-and-lower-respiratory-tract
#13
Zhi-Hong Feng, Qin Li, Si-Ran Liu, Xiao-Nan Du, Chen Wang, Xiu-Hong Nie, Wei Wang, Sun Ying
No abstract text is available yet for this article.
May 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28468657/hsya-alleviates-secondary-neuronal-death-through-attenuating-oxidative-stress-inflammatory-response-and-neural-apoptosis-in-sd-rat-spinal-cord-compression-injury
#14
Jun-Peng Pei, Li-Hong Fan, Kai Nan, Jia Li, Xiao-Qian Dang, Kun-Zheng Wang
BACKGROUND: Hydroxysafflor yellow A (HSYA) is a major active component of yellow pigment extracted from safflowers; this compound possesses potent neuroprotective effects both in vitro and in vivo. However, underlying mechanism of HSYA is not fully elucidated. The present study investigated the protective effects of HSYA in rat spinal cord compression injury model and related mechanisms involved. METHODS: Sprague-Dawley rats were divided as Sham, Control, and HSYA groups (n = 30 per group)...
May 3, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28463207/a-novel-continuous-blood-pressure-estimation-approach-based-on-data-mining-techniques
#15
Fen Miao, Nan Fu, Yuan-Ting Zhang, Xiao-Rong Ding, Xi Hong, Qingyun He, Ye Li
Continuous blood pressure (BP) estimation using pulse transit time (PTT) is a promising method for unobtrusive BP measurement. However, the accuracy of this approach must be improved for it to be viable for a wide range of applications. This study proposes a novel continuous BP estimation approach that combines data mining techniques with a traditional mechanism-driven model. First, 14 features derived from simultaneous electrocardiogram and photoplethysmogram signals were extracted for beat-to-beat BP estimation...
April 28, 2017: IEEE Journal of Biomedical and Health Informatics
https://www.readbyqxmd.com/read/28457760/a-comparison-between-chinese-and-caucasian-3-dimensional-bony-morphometry-in-presimulated-and-postsimulated-osteotomy-for-total-knee-arthroplasty
#16
Qian-Li Ma, Joseph D Lipman, Cheng-Kung Cheng, Xiao-Nan Wang, Yi-Yuan Zhang, Bin You
BACKGROUND: The bone morphologies of intact knees were measured and compared between Chinese and Caucasian populations. However, to assess if distinct designs of implants are necessary for the Chinese population owing to different morphologies and sizes, the knee measurements after osteotomy performed in total knee arthroplasty were evaluated. METHODS: Thirty-seven Caucasian and 50 Chinese patients' knees were examined using computed tomography scans. Mimics were applied to reconstruct 3-dimensional bone models...
April 7, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28454272/dinitrophenyl-hapten-with-laser-immunotherapy-for-advanced-malignant-melanoma-a-clinical-study
#17
Dian-Jun Chen, Xiao-Song Li, Hui Zhao, Yan Fu, Huan-Rong Kang, Fang-Fang Yao, Jia Hu, Nan Qi, Huan-Huan Zhang, Nan Du, Wei-R Chen
The present study aimed to evaluate the efficacy and safety of in situ immunotherapy with dinitrophenyl (DNP) hapten in combination with laser therapy for patients with malignant melanoma (MM). Between February 2008 and March 2012, 72 patients with stage III or IV MM were enrolled. Patients received in situ DNP alone (n=32) or in combination with laser therapy (n=32), and each group received dacarbazine chemotherapy. The levels of peripheral cluster of differentiation (CD)4(+)CD25(+) regulatory T cells (Tregs), interleukin (IL)-10 and tumor growth factor (TGF)-β were detected by ELISA...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28454236/prognostic-significance-of-cd30-expression-in-nasal-natural-killer-t-cell-lymphoma
#18
Guan-Nan Wang, Wu-Gan Zhao, Ling Li, Dan-Dan Zhang, Xian-Zheng Gao, Jun Zhou, Lei Zhang, Xiao-Rui Fu, Xiang-Yu Zheng, Ye Li, Zhen Li, Ming-Zhi Zhang, Wen-Cai Li
The present study aimed to investigate the expression of tumor necrosis factor receptor superfamily member 8 (CD30) in extranodal natural killer/T-cell lymphoma (ENKTL) using immunohistochemistry, and to evaluate the association between CD30 and clinicopathological and prognostic significance. CD30 expression was detected using immunohistochemistry on paraffin-embedded sections obtained from 122 patients with ENKTL prior to treatment. In total, 70 of these patients with complete clinical data were collected for prognostic analysis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28445968/usp22-knockdown-enhanced-chemosensitivity-of-hepatocellular-carcinoma-cells-to-5-fu-by-up-regulation-of-smad4-and-suppression-of-akt
#19
Jing Zhang, Nan Luo, Yu Tian, Jiazhi Li, Xiaozhou Yang, Huimin Yin, Congshu Xiao, Jie Sheng, Yang Li, Bo Tang, Rongkuan Li
USP22, a member of the deubiquitinases (DUBs) family, is known to be a key subunit of the human Spt-Ada-Gcn5 acetyltransferase (hSAGA) transcriptional cofactor complex. Within hSAGA, USP22 removes ubiquitin from histone proteins, thus regulating the transcription and expression of downstream genes. USP22 plays important roles in many cancers; however, its effect and the mechanism underlying HCC chemoresistance remain unclear. In the present study, we found that USP22 was highly expressed in chemoresistant HCC tissues and cells and was correlated with the prognosis of HCC patients who received chemotherapy...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28443566/atypical-chemokine-receptor-1-polymorphism-can-not-affect-susceptibility-to-hepatitis-c-virus
#20
Shu Ting Zhang, Ming Shi, Lin Nan Shao, Shi Hang Zhou, Wei Jian Yu, Mei Chen, Nan Xiao, Ying Duan, Ling Zi Pan, Ni Wang, Wen Qian Song, Yue Xin Xia, Li Zhang, Ning Qi, Ming Liu
BACKGROUND: Hepatitis C virus (HCV) has infected 130 to 150 million individuals globally. A significant number of chronically infected patients will develop liver cirrhosis, hepatocellular cancer and liver failure. Atypical Chemokine Receptor 1 (ACKR1) has become the focus because of its diverse roles in diseases. However, little is known regarding the association of ACKR1 polymorphism with the susceptibility to HCV. AIMS: The purpose of the present study is to determine the association of the ACKR1 polymorphisms (rs12075) with HCV susceptibility...
April 6, 2017: Balkan Medical Journal
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