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Xiao-Nan Li

Yi-Lin Zhang, Peng-Xiao Chen, Wei-Jie Guan, Hong-Mei Guo, Zhuo-Er Qiu, Jia-Wen Xu, Yu-Li Luo, Chong-Feng Lan, Jian-Bang Xu, Yuan Hao, Ya-Xia Tan, Ke-Nan Ye, Zhao-Rong Lun, Lei Zhao, Yun-Xin Zhu, Jiehong Huang, Wing-Hung Ko, Wei-De Zhong, Wen-Liang Zhou, Nan-Shan Zhong
Airway epithelial cells harbor the capacity of active Cl- transepithelial transport and play critical roles in modulating innate immunity. However, whether intracellular Cl- accumulation contributes to relentless airway inflammation remains largely unclear. This study showed that, in airway epithelial cells, intracellular Cl- concentration ([Cl- ]i ) was increased after Pseudomonas aeruginosa lipopolysaccharide (LPS) stimulation via nuclear factor-κB (NF-κB)-phosphodiesterase 4D (PDE4D)-cAMP signaling pathways...
March 15, 2018: Mucosal Immunology
Minghua Zheng, Jie Jiang, Xiao Zhang, Nan Wang, Kaihang Wang, Qiong Li, Tingting Li, Qingshan Lin, Yingbin Wang, Hai Yu, Ying Gu, Jun Zhang, Shaowei Li, Ningshao Xia
Hepatitis E virus (HEV) is associated with acute hepatitis disease. Numerous truncated HEV capsid proteins have been successfully expressed using different expression systems. Among these, p495, a protein truncated at its N- and C-termini by 111 and 54 amino acids (aa), respectively (HEV ORF2 aa 112-606) can self-assemble into T = 1 virus-like particles (VLPs) when expressed by insect cells. A shorter p239 (aa 368-606) protein is a particulate antigen that we have previously used in our commercialized HEV vaccine, Hecolin...
March 12, 2018: Vaccine
Qian Li, Xiao-Ji Lin, Hui Chen, Jian Gong, Zhen Li, Xiang-Nan Chen
More than 90% of patients with chronic myeloid leukemia (CML) have the chromosomal translocation t(9;22)(q34;q11), while 5-8% of patients have complex variant translocations that have previously been thought not to affect the efficacy of imatinib therapy. The present study reports a patient with CML in B-lymphoid blast crisis who had a rare three-way Philadelphia (Ph) variant t(3;9;22)(p21;q34;q11), in addition to isodicentric Ph chromosomes. The patient was initially treated with imatinib for >2 months with a very poor response...
April 2018: Oncology Letters
Cheng-Liang Yang, Xiao-Li Zheng, Ke Ye, Hong Ge, Ya-Nan Sun, Yu-Fei Lu, Qing-Xia Fan
N-Myc downstream-regulated gene 2 (NDRG2) has recently revealed as a candidate tumor suppressor gene. To inhibit tumor growth and decrease morbidity of esophageal cancer (EC), this study aims to test the hypothesis that the upregulation of NDRG2 may suppress proliferation, invasion, migration and epithelial-mesenchymal transition (EMT) of EC cells by regulating the AKT/XIAP signaling pathway. Immunohistochemistry was conducted for the identification of NDRG2, protein kinase B (p-AKT), X-linked inhibitor of apoptosis protein (XIAP) in EC tissues...
March 9, 2018: International Journal of Biochemistry & Cell Biology
Lin Zhang, Ran Chen, Rong Li, Meng-Ying Chen, Rong Huang, Xiao-Nan Li
BACKGROUND: To study the predictive factors of resting energy expenditure (REE) and evaluate the accuracy of predicted equations with indirect calorimeter (IC) in Chinese school-age children, particularly for the obese population. METHODS: Recruited children were from the department of child healthcare in Nanjing children's hospital during July 2014-September 2015. Anthropometric parameters and body composition were measured by bioelectrical impedance. Measured REE was assessed by IC...
March 7, 2018: World Journal of Pediatrics: WJP
Mingliang Zhang, Zhen Zhang, Kangmin He, Jimin Wu, Nan Li, Rong Zhao, Jinghe Yuan, Han Xiao, Youyi Zhang, Xiaohong Fang
The dynamics and stoichiometry of receptors newly delivered on plasma membrane play a vital role in cell signal transduction, yet the knowledge on this process is limited due to the lack of suitable methods. Here we developed a new strategy, which combines single-molecule imaging (SMI) and fluorescence recovery after photobleaching (FRAP), named FRAP-SMI, to monitor and quantify the newly delivered/inserted single transmembrane receptor on the plasma membrane of living cells. Transforming growth factor-β type II receptor (TβRII), a typical serine/threonine kinase receptor, was studied with this method...
March 6, 2018: Analytical Chemistry
Yi-Qing Zou, Xiao-Bao Li, Zhi-Xing Yang, Jing-Min Zhou, Yi-Nan Wu, Zhi-Hu Zhao, Xiang-Zhu Liu, Chang-Li Hu
BACKGROUND: Conflict findings of the impact of inhalational anesthetics on postoperative cognitive function are reported. No systematic review has been performed to solve the problem. The aim of the study was to assess the effect of different inhalational anesthetics on postoperative cognitive function in a network meta-analysis. METHODS: We will search MEDLINE, EMBASE, the Central Register of Controlled Trials in the Cochrane library, and CINAHL for randomized controlled trials or cohort studies assessing the short-term or long-term cognitive function of elderly patients (over 60 years) receiving major surgeries and inhalational anesthetics (desflurane, isoflurane, sevoflurane, halothane, and nitrous oxide) during surgery...
January 2018: Medicine (Baltimore)
Xiao-Hui Jin, Lan-Lan Zheng, Mei-Rong Song, Wei-Song Xu, Ya-Nan Kou, Yong Zhou, Li-Wei Zhang, Yan-Ning Zhu, Bo Wan, Zhan-Yong Wei, Gai-Ping Zhang
Inactivated transmissible gastroenteritis virus (TGEV) vaccines are widely used in swine herds in China. These are limited, however, by the need to elicit both humoral and cellular immunity, as well as the efficiency of adjuvants. In this study, a 70-nm nano silicon particle was applied with inactivated TGEV vaccine in mice, and its immune-enhancing effects and mechanism of action investigated. We found that nano silicon applied with inactivated TGEV vaccine induced high antibody titers, increase IL-6, TNF-α and IFN-γ expression, and stimulate CD3+ T cell proliferation with a high CD4+/CD8+ T lymphocyte ratio...
March 1, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Lin-Quan Tang, Dong-Ping Chen, Ling Guo, Hao-Yuan Mo, Ying Huang, Shan-Shan Guo, Bin Qi, Qing-Nan Tang, Pan Wang, Xiao-Yun Li, Ji-Bin Li, Qing Liu, Yuan-Hong Gao, Fang-Yun Xie, Li-Ting Liu, Yang Li, Sai-Lan Liu, Hao-Jun Xie, Yu-Jing Liang, Xue-Song Sun, Jin-Jie Yan, Yi-Shan Wu, Dong-Hua Luo, Pei-Yu Huang, Yan-Qun Xiang, Rui Sun, Ming-Yuan Chen, Xing Lv, Lin Wang, Wei-Xiong Xia, Chong Zhao, Ka-Jia Cao, Chao-Nan Qian, Xiang Guo, Ming-Huang Hong, Zhi-Qiang Nie, Qiu-Yan Chen, Hai-Qiang Mai
BACKGROUND: Cisplatin-based concurrent chemoradiotherapy is currently considered to be the standard treatment regimen for patients with advanced nasopharyngeal carcinoma, but has well known side-effects such as gastrointestinal reactions, nephrotoxicity, and ototoxicity. Nedaplatin was developed to decrease the toxic effects induced by cisplatin, and in this trial we assessed whether a nedaplatin-based concurrent chemoradiotherapy regimen was non-inferior to a cisplatin-based regimen in patients with locoregional, stage II-IVB nasopharyngeal carcinoma...
February 28, 2018: Lancet Oncology
Long Sun, Ya-Nan Zhang, Jia-Li Qian, Ke Kang, Xiao-Qing Zhang, Jun-Dan Deng, Yan-Ping Tang, Cheng Chen, Laura Hansen, Tian Xu, Qing-He Zhang, Long-Wa Zhang
The citrus long-horned beetle (CLB), Anoplophora chinensis (Forster) is a destructive native pest in China. Chemosensory receptors including odorant receptors (ORs), gustatory receptors (GRs), and ionotropic receptors (IRs) function to interface the insect with its chemical environment. In the current study, we assembled the antennal transcriptome of A. chinensis by next-generation sequencing. We assembled 44,938 unigenes from 64,787,784 clean reads and annotated their putative gene functions based on gene ontology (GO) and Clusters of Orthologous Groups of proteins (COG)...
2018: Frontiers in Physiology
Peng-Yue Li, Shou-Ying Du, Yang Lu, Xiao-Nan Chen
Bio-adhesive drug delivery system (BDDS) is a novel drug delivery system, which can prolong the retention time of the preparation, improve the stability of the drug, and improve the mucosa absorption and the targeting of the drug. With the development of polymer materials over the past 30 years, BDDS made a great progress. This paper reviews the muco-adhesion theory, adhesive materials, and methods to evaluate muco-adhesive properties and applications in traditional Chinese medicine according to domestic and foreign literatures, in order to provide new ideas for further studies...
December 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Wen-Jing Li, Chang Xu, Kun Wang, Teng-Yan Li, Xiao-Nan Wang, Hui Yang, Tiaosi Xing, Wen-Xia Li, Yan-Hua Chen, Hong Gao, Lei Ding
BACKGROUND: As a potential tumor suppressor gene, Claudin-7 (Cldn7), which is a component of tight junctions, may play an important role in colorectal cancer occurrence and development. AIMS: To generate a knockout mouse model of inducible conditional Cldn7 in the intestine and analyze the phenotype of the mice after induction with tamoxifen. METHODS: We constructed Cldn7-flox transgenic mice and crossed them with Villin-CreERT2 mice. The Cldn7 inducible conditional knockout mice appeared normal and were well developed at birth...
February 27, 2018: Digestive Diseases and Sciences
Xiao-Lin Xiao, Nan Hu, Xin-Zi Zhang, Man Jiang, Chang Chen, Rui Ma, Zhen-Gang Ma, Jin-Lai Gao, Xiu-Chen Xuan, Zhi-Jie Sun, De-Li Dong
BACKGROUND AND PURPOSE: The anti-helminthic drug niclosamide regulates multiple cellular signals including STAT3, AMPK, Akt, Wnt/β-catenin, and mitochondrial uncoupling which involved in neointimal hyperplasia. Therefore, the aim of the present study is to examine the effects of the niclosamide on vascular smooth muscle cell proliferation, migration, and neointimal hyperplasia and elucidate the potential mechanisms. EXPERIMENTAL APPROACH: Cell migration was measured by using wound-induced migration assay and Boyden chamber assay...
February 27, 2018: British Journal of Pharmacology
Zhen Cai, Zhen-Yu Qian, Hao Jiang, Ning Ma, Zhi Li, Li-Yu Liu, Xin-Xin Ren, Yu-Rong Shang, Jing-Jing Wang, Jing-Jing Li, Dong-Ping Liu, Xiu-Ping Zhang, Dan Feng, Qian-Zhi Ni, Yuan-Yuan Feng, Nan Li, Xiao-Yan Zhou, Xiang Wang, Ying Bao, Xue-Li Zhang, Yue-Zhen Deng, Dong Xie
Two isoforms of human Polycomb-like protein 3 (hPCL3) have been reported as components of the nuclear Polycomb repressive complex 2 (PRC2) with the short isoform (hPCL3s) showing a dominant cytoplasmic localization. The function of cytoplasmic hPCL3s has however not been addressed. In this study, we report that hPCL3s is upregulated in clinical hepatocellular carcinoma (HCC) samples and its expression correlated with HCC clinical features. hPCL3s positively regulated the migration, invasion, and metastasis of HCC cells...
February 26, 2018: Cancer Research
Nan Zheng, Yan-Yan Chi, Xiao-Han Yang, Nan-Xing Wang, Yi-Lin Li, Yang-Yang Ge, Lan-Xin Zhang, Tai-Yuan Liu, Xiao-Ying Yuan, Sheng-Bo Yu, Hong-Jin Sui
BACKGROUND CONTEXT: Studies over the last 20 years have revealed that there are fibrous connective tissues between the suboccipital muscles, nuchal ligament and cervical spinal dura mater(SDM). This fibrous connection with the SDM is through the posterior atlanto-occipital and/or atlanto-axial interspaces and is called the Myodural Bridge(MDB). Researches have inferred that the MDB might have important functions. It was speculated that the function of MDB might be related to proprioception transmission, keeping the subarachnoid space and the cerebellomedullary cistern unobstructed, and affecting the dynamic circulation of the cerebrospinal fluid (CSF)...
February 22, 2018: Spine Journal: Official Journal of the North American Spine Society
Li Yi-Feng, Hang Chun-Qin, Hu Fei, Yuan Min, Gu Xiao-Nan, Lü Shang-Biao, Zeng Xiao-Jun, Lin Dan-Dan
OBJECTIVE: To evaluate the role of new strategy in the transmission control of schistosomiasis in Poyang Lake region. METHODS: The information and epidemic data of schistosomiasis control were collected and analyzed in Poyang Lake region from 2005 to 2016. RESULTS: After eleven years of carrying out the new strategy, thirteen counties achieved the objective of transmission control in Poyang Lake region. In 2016, the number of schistosomiasis cases and human infection rate were 10 301 and 0...
December 26, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
Jun-Nan Tang, Jhon Cores, Ke Huang, Xiao-Lin Cui, Lan Luo, Jin-Ying Zhang, Tao-Sheng Li, Li Qian, Ke Cheng
Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell-based and cell-free paradigms, their limitations, and the benefits of using them to target disease. Stem Cells Translational Medicine 2018...
February 22, 2018: Stem Cells Translational Medicine
Nan-Yang Li, Lei Zhou, Dan-Dan Zhang, Steven J Klosterman, Ting-Gang Li, Yue-Jing Gui, Zhi-Qiang Kong, Xue-Feng Ma, Dylan P G Short, Wen-Qi Zhang, Jun-Jiao Li, Krishna V Subbarao, Jie-Yin Chen, Xiao-Feng Dai
Verticillium wilt caused by Verticillium dahliae results in severe losses in cotton, and is economically the most destructive disease of this crop. Improving genetic resistance is the cleanest and least expensive option to manage Verticillium wilt. Previously, we identified the island cotton NBS-LRR-encoding gene GbaNA1 that confers resistance to the highly virulent V. dahliae isolate Vd991. In this study, we expressed cotton GbaNA1 in the heterologous system of Arabidopsis thaliana and investigated the defense response mediated by GbaNA1 following inoculations with V...
2018: Frontiers in Plant Science
Xiao-Nan Li, Mari Kogiso, Lin Qi, Frank K Braun, Sarah G Injac, Linna Zhang, Yuchen Du, Huiyuan Zhang, Frank Y Lin, Sibo Zhao, Holly Lindsay, Jack Mf Su, Patricia A Baxter, Adekunle M Adesina, Debra Liao, Mark G Qian, Stacey L Berg, Jodi Muscal
PURPOSE: Pediatric glioblastoma (pGBM) is highly aggressive tumor in need of novel therapies. Our objective was to demonstrate the therapeutic efficacy of MLN8237 (Alisertib), an orally available selective inhibitor of Aurora A kinase (AURKA), and to evaluate which in vitro model system (monolayer or neurosphere) can predict therapeutic efficacy in vivo. EXPERIMENTAL DESIGN: AURKA mRNA expressions were screened with qRT-PCR. In vitro anti-tumor effects were examined in 3 matching pairs of monolayer and neurosphere lines established from patient derived orthotopic xenograft (PDOX) models of the untreated (IC-4687GBM), recurrent (IC-372GBM) and terminal (IC-R0315GBM) tumors; and in vivo therapeutic efficacy through log rank analysis of survival times in 2 models (IC-4687GBM and IC-R0315GBM) following MLN8237 treatment (30 mg/kg/day, p...
February 20, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Nan Zheng, Yu-Xuan Sun, Liang-Li Yang, Liang Wu, Muhammad Nadeem Abbas, Chen Chen, Jin Gao, Xiao-Kun Li, Chao-Liang Liu, Li-Shang Dai
The complete mitochondrial genome (mitogenome) of Biston marginata (Lepidoptera: Geometridae) was determined and annotated. The circular genome is 15,470 bp long and it contains the entire set of 37 genes usually present in lepidopteran mitogenomes. The nucleotide composition of the genome is highly A + T biased, accounting for 81.20%, with a slightly positive AT skewness (0.028), indicating the occurrence of more As than Ts, as found in other Geometridae species. Except for cox1 gene starts with non-canonical initial codon CGA, all protein-coding genes start with ATN codon...
February 17, 2018: International Journal of Biological Macromolecules
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