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Xiao-Nan Li

Ya-Nan Wang, Mao-Feng Liu, Wei-Zhen Hou, Rui-Ming Xu, Jie Gao, An-Qi Lu, Mei-Ping Xie, Lan Li, Jian-Jun Zhang, Ying Peng, Li-Li Ma, Xiao-Liang Wang, Jian-Gong Shi, Su-Juan Wang
Four new benzofuran-type stilbene glycosides and 14 known compounds including 8 benzofuran-type stilbenes and 6 flavonoids were isolated from the traditional Chinese medicine, Cortex Mori Radicis. The new compounds were identified as (9R)-moracin P 3'-O-α-l-arabinopyranoside (1), (9R)-moracin P 9-O-β-d-glucopyranoside (2), (9R)-moracin P 3'-O-β-d-glucopyranoside (3), and (9R)-moracin O 10-O-β-d-glucopyranoside (4) based on the spectroscopic interpretation and chemical analysis. Three benzofuran-type stilbenes, moracin O (5), R (7), and P (8) showed significant neuroprotective activity against glutamate-induced cell death in SK-N-SH cells...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Yue-Jing Gui, Jie-Yin Chen, Dan-Dan Zhang, Nan-Yang Li, Ting-Gang Li, Wen-Qi Zhang, Xin-Yan Wang, Dylan P G Short, Lei Li, Wei Guo, Zhi-Qiang Kong, Yu-Ming Bao, Krishna V Subbarao, Xiao-Feng Dai
Glycoside hydrolase 12 (GH12) proteins act as virulence factors and pathogen-associated molecular patterns (PAMPs) in oomycetes. However, the pathogenic mechanisms of fungal GH12 proteins have not been characterized. In this study, we demonstrated that two of the six GH12 proteins produced by the fungus Verticillium dahliae Vd991, VdEG1 and VdEG3 acted as PAMPs to trigger cell death and PAMP-triggered immunity (PTI) independent of their enzymatic activity in Nicotiana benthamiana. A 63-amino-acid peptide of VdEG3 was sufficient for cell death-inducing activity, but this was not the case for the corresponding peptide of VdEG1...
February 15, 2017: Environmental Microbiology
Jun-Tao Yu, Jian-Nan Li, Jia Wang, Xiao-Yu Jia, Zhao Cui, Ming-Hui Zhao
Myeloperoxidase (MPO) is a common target antigen of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis and is recognized in one-third of patients with anti-glomerular basement membrane (GBM) disease. Our previous study identified over 60% of patients with anti-GBM disease recognizing linear peptides of MPO heavy chain. Here we tested whether aberrant glycosylation alters MPO antigenicity through exposure of neo-epitopes on MPO molecules. Atypical glycosylated MPO molecules, including all possible glycosylation types, were prepared by exoglycosidase and endoglycosidase treatments...
February 7, 2017: Kidney International
Sen Liu, Nan Wu, Yuzhi Zuo, Yangzhong Zhou, Jiaqi Liu, Zhenlei Liu, Weisheng Chen, Gang Liu, Yixin Chen, Jia Chen, Mao Lin, Yanxue Zhao, Yue Ming, Tangmi Yuan, Xiao Li, Zenan Xia, Xu Yang, Yufen Ma, Jianguo Zhang, Jianxiong Shen, Shugang Li, Yipeng Wang, Hong Zhao, Keyi Yu, Yu Zhao, Xisheng Weng, Guixing Qiu, Zhihong Wu
STUDY DESIGN: A case-control association study was performed to investigate the relationship between LBX1 and adolescent idiopathic scoliosis (AIS) in Northern Chinese Han population. OBJECTIVE: To explore the prevalence and functional importance of LBX1 polymorphisms in AIS patients within the Northern Chinese Han population. SUMMARY OF BACKGROUND DATA: AIS is the most common subtype of idiopathic scoliosis. Genetic factors such as LBX1 polymorphisms have been recently proved to be associated with AIS in some populations...
February 9, 2017: Spine
Jing Xie, Ju-Ping Yun, Ya-Nan Yang, Fang Hua, Xiao-Wei Zhang, Heng Lin, Xiao-Xi Lv, Ke Li, Pei-Cheng Zhang, Zhuo-Wei Hu
Autophagy-induced cancer cell death has become a novel strategy for the development of cancer therapeutic drugs. Numerous studies have indicated that green tea polyphenols induce both autophagy and apoptosis in a variety of cancer cells. Here, we synthesized a series of green tea polyphenol analogues, among which JP8 was shown to potently activate autophagy. JP8 treatment had a stronger effect on apoptosis in B16-F10 melanoma cells than that in normal AML-12 hepatocytes. JP8 selectively resulted in reactive oxygen species (ROS) accumulation in B16-F10 cells, and this effect was associated with corresponding increases in key components of the ER stress-mediated apoptosis pathway...
February 10, 2017: Scientific Reports
Xiao-Xin Zhang, Li-Hui Deng, Wei-Wei Chen, Na Shi, Tao Jin, Zi-Qi Lin, Yun Ma, Kun Jiang, Xiao-Nan Yang, Qing Xia
BACKGROUND: To study the value of circulating microRNA 216 (miR-216) as a marker for the severity of acute pancreatitis (AP) in both murine models and patients. MATERIALS AND METHODS: Mice with AP were induced by intraperitoneal injection of 50μg/kg/hour cerulean either 7 times, sacrificed at 8, 9, 10, 11 or 12 hours after the first injection, or 12 times, sacrificed at 24 hours after the first injection. Plasma samples and data from patients with AP were obtained from a prospective cohort...
February 2017: American Journal of the Medical Sciences
Xiu-Ming Li, Jing-Ru Wang, Tong Shen, Shang-Shang Gao, Xiao-Shun He, Jiang-Nan Li, Tian-Yu Yang, Shen Zhang, Wen-Juan Gan, Jian-Ming Li, Hua Wu
Nur77, an orphan member of the nuclear receptor superfamily, plays critical roles in inflammation and immunity. However, the role of Nur77 in tumor microenvironment remains elusive. Results showed that deletion of Nur77 strikingly enhanced tumor metastasis compared to WT mice. Additionally, compared to the conditioned media derived from Nur77+/+ peritoneal macrophages (CM1), the conditioned media derived from Nur77-/- peritoneal macrophages (CM2) significantly promoted the EMT of cancer cells, and greatly enhanced the migratory and invasive abilities of cancer cells...
2017: PloS One
Yan Li, Sheng-Li Zhao, Jin-Lu Li, Xiao-Hong Hu, He Wang, Xiao-Long Cao, Yong-Ju Xu, Zhi-Xue Zhao, Zhi-Yuan Xiao, Nan Yang, Jing Fan, Fu Huang, Wen-Ming Wang
miR169 is a conserved microRNA (miRNA) family involved in plant development and stress-induced responses. However, how miR169 functions in rice immunity remains unclear. Here, we show that miR169 acts as a negative regulator in rice immunity against the blast fungus Magnaporthe oryzae by repressing the expression of nuclear factor Y-A (NF-YA) genes. The accumulation of miR169 was significantly increased in a susceptible accession but slightly fluctuated in a resistant accession upon M. oryzae infection. Consistently, the transgenic lines overexpressing miR169a became hyper-susceptible to different M...
2017: Frontiers in Plant Science
Xiao Fu, Hongqing Wen, Li Jing, Yujuan Yang, Wenjuan Wang, Xuan Liang, Kejun Nan, Yu Yao, Tao Tian
MicroRNA-155-5p (miR-155-5p) has been reported to play an oncogenic role in different human malignancies; however, its role in HCC progression is not clearly understood. In this study, we used real-time PCR in 20 rats with chemically-induced HCC, 28 human HCC tissues, and the matched paracarcinoma tissues, and HCC cell lines to determine the expression patterns of miR-155-5p and PTEN mRNA. Algorithm-based and experimental strategies, such as dual luciferase gene reporter assays, real-time PCR, and Western Blots were used to identify PTEN as a candidate miR-155-5p target...
January 28, 2017: Cancer Science
Yan Zhang, Xiao-Li Li, Nan-Nan Sha, Bing Shu, Yong-Jian Zhao, Xin-Luan Wang, Hui-Hui Xiao, Qi Shi, Man-Sau Wong, Yong-Jun Wang
The components of renin-angiotensin system (RAS) are expressed in the kidney and bone. Kidney disease and bone injury are common complications associated with diabetes. This study aimed to investigate the effects of an angiotensin-converting enzyme inhibitor, captopril, on the kidney and bone of db/db mice. The db/db mice were orally administered by gavage with captopril for 8weeks with db/+ mice as the non-diabetic control. Serum and urine biochemistries were determined by standard colorimetric methods or ELISA...
January 24, 2017: Bone
Xiao-Yan Zheng, Yi-Fei Lv, Shuang Li, Qian Li, Qian-Nan Zhang, Xue-Ting Zhang, Zhi-Ming Hao
AIM: To investigate the protective effect of a recombinant adeno-associated virus carrying thymosin β4 (AAV-Tβ4) on murine colitis via intracolonic administration. METHODS: AAV-Tβ4 was prepared and intracolonically used to mediate the secretory expression of Tβ4 in mouse colons. Dextran sulfate sodium (DSS) was applied to induce the murine ulcerative colitis, and 2,4,6-trinitrobenzene sulfonic acid (TNBS) was used to establish a mouse colitis model resembling Crohn's disease...
January 14, 2017: World Journal of Gastroenterology: WJG
Wen-Shuai Jiang, Wei Xin, Shao-Nan Chen, Cun-Bo Li, Xiao-Guang Gao, Lei-Ting Pan, Zhi-Bo Liu, Jian-Guo Tian
Protein-protein interactions play an important role in the investigation of biomolecules. In this paper, we reported on the use of a reduced graphene oxide microshell (RGOM)-based optical biosensor for the determination of goat anti-rabbit IgG. The biosensor was prepared through a self-assembly of monolayers of monodisperse polystyrene microspheres, combined with a high-temperature reduction, in order to decorate the RGOM with rabbit IgG. The periodic microshells allowed a simpler functionalization and modification of RGOM with bioreceptor units, than reduced graphene oxide (RGO)...
January 24, 2017: Sensors
Nan Liu, Yi Guan, Ling Xue, Yan Yu, Jingwei Xiao, Zhimin Chang, Qingzhao Li, Yuping Bai, Bin Li, Weijun Guan
This study was conducted to investigate possible genotoxic effects resulting from occupational exposure to indium compounds. We performed a cytogenetic analysis of peripheral blood lymphocytes gathered from 57 individuals exposed to indium at an indium ingot production plant in Guangxi, China, and compared the results with those obtained from 63 control subjects. The lymphocytes from both groups were examined in the chromosomal aberrations (CAs) assay, cytokinesis-block micronucleus (CBMN) assay, and single-cell gel electrophoresis (comet) assay...
January 23, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
Lin Yang, Zi-Bin Tian, Ya-Nan Yu, Cui-Ping Zhang, Xiao-Yu Li, Tao Mao, Xue Jing, Wen-Jun Zhao, Xue-Li Ding, Ruo-Ming Yang, Shuai-Qing Zhang
Helicobacter suis has a greater tendency to induce gastric mucosa-associated lymphoid tissue (MALT) lymphoma compared with other Helicobacter species in humans and animals. Saccharomyces (S.) boulardii has been established as an adjunct to Helicobacter pylori eradication treatment, but the effect of S. boulardii administration alone on Helicobacter infection remains unclear. Here, we found that S. boulardii administration effectively decreased the bacterial load of Helicobacter suis and inhibited the formation of lymphoid follicles in the stomach post-infection...
January 22, 2017: Pathogens and Disease
Yi-Ming Zhang, Xiao-Yu Dong, Li-Juan Fan, Zhi-Lei Zhang, Qian Wang, Nan Jiang, Xu-Shu Yang
Poly- and perfluorinated compounds (PFCs), which have been detected worldwide in human blood, surface water and house dust, are suspected to induce potential endocrine-disrupting hormonal effects. In this study, cell-based reporter gene assays were used to determine the activity of a variety of PFCs against the human pregnane X receptor (hPXR) to identify the critical structural feature of PFCs related to their hPXR activity. Molecular docking studies combined with site-directed mutagenesis were employed to investigate the mechanism by which PFCs interact with and activate hPXR...
January 20, 2017: Toxicology
Hua-Wei Wang, Xiao-Yue Li, Zhi-Peng Hao, Ying-Jie Sun, Ya-Nan Wang, Wei-Hua Li, Yiu Fai Tsang
In this study, the transformation of dissolved organic matter (DOM) in nanofiltration concentrated leachate during three ozone-based oxidation processes (i.e., O3, O3/H2O2 and O3/UV) was investigated. The transformation characteristics of DOM were evaluated by gel filtration chromatography (GFC), XAD-8 resin fractionation, excitation-emission matrix fluorescence spectroscopy (EEM) and Fourier transform infrared spectroscopy (FTIR). Compared with O3-alone process, the removal efficiencies of COD, TOC, and color were improved in O3-combined processes (i...
January 19, 2017: Journal of Environmental Management
Xiaoyan Qiu, Haihong You, Xiong Xiao, Nan Li, Yuemin Li
The low success rate of animal cloning by somatic cell nuclear transfer (SCNT) is believed to be associated with aberrant epigenetic nuclear reprogramming. It has been demonstrated that treatment with histone deacetylase inhibitors (HDACis) enhances developmental potential of SCNT embryos. Previous studies in many species revealed that treatment of SCNT embryos with trichostatin A (TSA)-an HDACi-significantly enhances the in vitro development of SCNT embryos. In this study, we compared two different SCNT protocols with TSA and investigate, for the first time, the effect of another new HDACi, PXD101 (belinostat), on in vitro development of mouse SCNT embryo...
February 2017: Cellular Reprogramming
Ai-Rong Su, Min Qiu, Yan-Lei Li, Wen-Tao Xu, Si-Wei Song, Xiao-Hui Wang, Hong-Yong Song, Nan Zheng, Zhi-Wei Wu
BX-795, an aminopyrimidine compound, was developed as an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1) and was later shown to be a potent inhibitor of the IKK-related kinase, TANK-binding kinase 1 (TBK1) and IKKɛ. The currect study aimed to investigate the inhibition mechanism(s) of BX-795 on Herpes simplex virus (HSV) replication. HEC-1-A or Vero cells were treated in the absence or presence of serial concentrations of BX-795 and infected with HSV-1 or HSV-2 for different periods. BX-795 did not suppress HSV IE gene transcription at 6 h postinfection...
January 23, 2017: Acta Pharmacologica Sinica
Qiang Guo, Lin Meng, Ya-Nan Zhang, Pei-Chun Mao, Xiao-Xia Tian, Shan-Shan Li, Lin Zhang
Iris lactea is a perennial halophyte and is tolerant to Cd. However, the mechanisms underlying this Cd tolerance are still poorly understood. In this study, morphological, physiological and biochemical responses of I. lactea to a 21 d exposure to different concentrations of Cd (0-150mgL(-1)) were investigated. I. lactea plants showed no toxicity symptoms except for a small reduction in growth at 100 and 150mgL(-1) Cd, along with the enhancement of H2O2 and MDA content in comparison to the control. The activities of SOD and POD were significantly enhanced and Ca accumulated with increasing Cd concentrations...
January 19, 2017: Ecotoxicology and Environmental Safety
Jing-Yi Li, Fang Xie, Xiao-Ping Xu, Juan-Juan Ma, Dai-Chao Zhou, Yan Liao, Jing Tang, Qian Xie, Lan Bai, Qing-Zhen Nan
OBJECTIVE: To investigate the expression of claudin-3 in colorectal carcinoma and its association with the occurrence, progression and prognosis of colorectal cancer. METHODS: Forty surgical specimens of colorectal carcinoma and 22 adjacent normal tissues resected between October, 2010 and January, 2013 at Nanfang Hospital were examined for claudin-3 expression using immunohistochemistry, which was analyzed in association with the clinicopathological parameters and the survival of the patients...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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