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Xiao-Nan Li

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https://www.readbyqxmd.com/read/28916980/pharmacokinetics-of-panax-notoginseng-saponins-in-adhesive-and-normal-preparation-of-fufang-danshen
#1
Xiao-Nan Chen, Dan-Qi Li, Meng-di Zhao, Gang-Yan Yu, Shou-Ying Du, Yang Lu, Jie Bai, Peng-Yue Li, Ya-Li Wu, Zhi-Hao Tian, Yan-Ying Zeng
BACKGROUND AND OBJECTIVE: Fufang Danshen formula, a famous Chinese patent medicine containing Salvia miltiorrhiza, Panax notoginseng and borneol, has been widely used in the treatment of coronary heart disease. The application is restricted by low bioavailability partly due to Panax notoginseng saponins (PNS) instability and low in vivo absorption. Thus, adhesive pellets were developed to improve bioavailability. The objectives of the present study were to evaluate the adhesive preparation by describing PNS's plasma pharmacokinetics in vivo and compare adhesive micro pills with normal preparation...
September 15, 2017: European Journal of Drug Metabolism and Pharmacokinetics
https://www.readbyqxmd.com/read/28915657/the-prevalence-subtypes-and-associated-factors-of-hyperuricemia-in-lupus-nephritis-patients-at-chronic-kidney-disease-stages-1-3
#2
Simeng Liu, Yijun Gong, Hong Ren, Wen Zhang, Xiaonong Chen, Tong Zhou, Xiao Li, Nan Chen
There is a high prevalence of hyperuricemia (HUA) in the chronic kidney disease (CKD) population. However, there's a dearth of research on HUA's prevalence, subtypes, early detection, and treatment strategies of HUA in lupus nephritis (LN) patients. The aim of this study is to address these knowledge gaps. LN patients presenting to the Department of Nephrology at Shanghai Rui Jin Hospital from January 2011 to January 2016 were recruited. The effective sample size was derived using the power analysis. The demographic, clinical and laboratory characteristics of the LN patients with HUA were compared with those of patients without HUA...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28914419/social-isolation-during-adolescence-induces-anxiety-behaviors-and-enhances-firing-activity-in-bla-pyramidal-neurons-via-mglur5-upregulation
#3
Song Lin, Xin Li, Yi-Hua Chen, Feng Gao, Hao Chen, Neng-Yuan Hu, Lang Huang, Zheng-Yi Luo, Ji-Hong Liu, Qiang-Long You, Ya-Nan Yin, Ze-Lin Li, Xiao-Wen Li, Zhuo-Jun Du, Jian-Ming Yang, Tian-Ming Gao
Social isolation during the vulnerable period of adolescence contributes to the occurrence of psychiatric disorders and profoundly affects brain development and adult behavior. Although the impact of social isolation during adolescence on anxiety behaviors has been well studied, much less is known about the onset and underlying mechanisms of these behaviors. We observed that following 2 weeks, but not 1 week, of social isolation, adolescent mice exhibited anxiety behaviors. Strikingly, the mGluR5 protein levels in the amygdala increased concomitantly with anxiety behaviors, and both intraperitoneal administration and intra-basolateral amygdala (BLA) infusion of MPEP, a metabotropic glutamate receptor 5 antagonist, normalized anxiety behaviors...
September 15, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28911036/high-fat-diet-induced-obesity-upregulates-the-expression-of-lymphoid-chemokines-and-promotes-the-formation-of-gastric-lymphoid-follicles-after-helicobacter-suis-infection
#4
Wen-Jun Zhao, Zi-Bin Tian, Shan-Shan Yao, Ya-Nan Yu, Cui-Ping Zhang, Xiao-Yu Li, Tao Mao, Xue Jing, Xue-Li Ding, Ruo-Ming Yang, Ya-Qian Liu, Shuai-Qing Zhang, Lin Yang
Helicobacter suis colonizes the stomachs of a variety of animals, including humans, and is more likely than other Helicobacter species to induce gastric mucosa-associated lymphoid tissue lymphoma. Obesity is a low-grade chronic inflammatory state in which the induction of a chemokine network contributes to a variety of diseases. However, the effect of obesity on the development of gastric MALT in the presence of H. suis infection remains unclear. Here, we reveal that high-fat-diet-induced obesity upregulates the expression of lymphoid chemokines in the stomach and accelerates the H...
November 30, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28905934/conversion-and-pharmacokinetics-profiles-of-a-novel-pro-drug-of-3-n-butylphthalide-potassium-2-1-hydroxypentyl-benzoate-in-rats-and-dogs
#5
Jiang Li, Shao-Feng Xu, Ying Peng, Nan Feng, Ling Wang, Xiao-Liang Wang
Potassium 2-(1-hydroxypentyl)-benzoate (dl-PHPB) is a novel pro-drug of 3-n-butylphthalide (dl-NBP) that is used to treat ischemic stroke. Currently, dl-PHPB is in phase II-III clinical trials in China. In this study, we investigated the conversion and pharmacokinetics profiles of dl-PHPB in vitro and in vivo. The conversion of dl-PHPB to dl-NBP was pH- and calcium-dependent, and paraoxonase was identified as a major enzyme for the conversion in rat plasma. The pharmacokinetics, tissue distribution and excretion of dl-PHPB were studied and compared with equal-molar doses of dl-NBP in rats and dogs...
September 14, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28903457/the-lifecycle-of-the-ebola-virus-in-host-cells
#6
REVIEW
Dong-Shan Yu, Tian-Hao Weng, Xiao-Xin Wu, Frederick X C Wang, Xiang-Yun Lu, Hai-Bo Wu, Nan-Ping Wu, Lan-Juan Li, Hang-Ping Yao
Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28903433/microrna-451-modulated-hnrnp-a1-takes-a-part-in-granulocytic-differentiation-regulation-and-acute-myeloid-leukemia
#7
Li Song, Hai-Shuang Lin, Jia-Nan Gong, Hua Han, Xiao-Shuang Wang, Rui Su, Ming-Tai Chen, Chao Shen, Yan-Ni Ma, Jia Yu, Jun-Wu Zhang
Myelopoiesis is under the control of a complex network containing various regulation factors. Deregulation of any important regulation factors may result in serious consequences including acute myeloid leukemia (AML). In order to find out the genes that may take a part in AML development, we analyzed data from AML cDNA microarray (GSE2191) in the NCBI data pool and noticed that heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is abnormally over-expressed in AML patients. Then we investigated the function and mechanisms of hnRNP A1 in myeloid development...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28881753/sirna-mediated-inactivation-of-her3-improves-the-antitumour-activity-and-sensitivity-of-gefitinib-in-gastric-cancer-cells
#8
Heng-Heng Yuan, Ying-Nan Yang, Jian-Hua Zhou, Yan-Jing Li, Li-Ying Wang, Jun-Wei Qin, Tao Liu, Zhen-Zhen Li, Qing-Xin Zhou, Xiao-Li Wei, Ting-Ting Zhang, Peng Huang, Wen-Jie Zhang, Lei Liu, Xiao-Xue Du, Yu Han
The human EGFR family consists of four type-1 transmembrane tyrosine kinase receptors: HER1 (EGFR, ErbB1), HER2 (Neu, ErbB2), HER3 (ErbB3), and HER4 (ErbB4). HER3 can dimerize with EGFR, HER2 and even c-Met and likely plays a central role in the response to EGFR-targeted therapy. Because HER3 lacks significant kinase activity and cannot be inhibited by tyrosine kinase inhibitors, neutralizing antibodies and alternative inhibitors of HER3 have been sought as cancer therapeutics. Here, we describe the stable suppression of HER3 mRNA and protein using siRNA...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28865311/nlrc5-promotes-cell-proliferation-via-regulating-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-rheumatoid-arthritis
#9
Ya-Ru Liu, Xing Yan, Hai-Xia Yu, Yao Yao, Jie-Quan Wang, Xiao-Feng Li, Ruo-Nan Chen, Qing-Qing Xu, Tao-Tao Ma, Cheng Huang, Jun Li
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease and the pathogenesis remains unclear. Previous studies suggested that fibroblast-like synoviocytes (FLSs) play an important role in RA pathogenesis, including the injury of cartilage, the hyperplasia of the synovium and the release of inflammatory cytokines. We used complete Freund's adjuvant (CFA) induced rats as animal models for studying the RA pathogenesis. NLRC5 as the largest member of the NLR family has been reported to play a critical role in regulating immune responses...
August 30, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28860066/novel-peptide-mt23-for-potent-penetrating-and-selective-targeting-in-mouse-melanoma-cancer-cells
#10
Nan Zhou, Jiao Wu, Yan-Yan Qin, Xue-Li Zhao, Yi Ding, Li-Sha Sun, Tong He, Xiao-Wen Huang, Chang-Bai Liu, Hu Wang
Cell-penetrating peptides (CPPs) have a great potential for intracellular delivery of cell-impermeable biological macromolecules in clinical therapy. However, their lack of cell and tissue specificity remains the primary limitation for their clinical development as drug delivery vehicles. In this study, based on phage display and an in silico approach, we found a novel CPP-MT23 with mouse melanoma cell specificity, it can only enter B16 melanoma cancer cells and without any cytotoxicity, Moreover, MT23 showed higher penetration efficiency based on fluorescence microcopy and quantitative assay, and it has capability for mediating functional Apoptin into cells in vitro or in vivo...
August 28, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28858297/yl-0919-a-dual-5-ht1a-partial-agonist-and-ssri-produces-antidepressant-and-anxiolytic-like-effects-in-rats-subjected-to-chronic-unpredictable-stress
#11
Yu-Hua Ran, Xiao-Xu Hu, Yu-Lu Wang, Nan Zhao, Li-Ming Zhang, Hua-Xia Liu, Yun-Feng Li
YL-0919 has been identified as a novel dual 5-HT1A partial agonist and serotonin reuptake inhibitor. In the current study, we demonstrated that YL-0919 produced prominent antidepressant-like and anxiolytic-like effects in a chronic unpredictable stress (CUS) rat model. Male SD rats were exposed to CUS for 5 weeks; YL-0919 (1.25 and 2.5 mg/kg) or a positive control fluoxetine (Flx, 10 mg/kg) was orally administered daily. YL-0919 or Flx treatment significantly increased the sucrose preference rate, the locomotor activity in an open field test (OFT), the latency to feed in a novelty-suppressed feeding test (NSFT), and both the percentage of time spent in the open arms and the number of entries into the open arms in an elevated plus-maze test...
August 31, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28846924/the-circular-rna-of-peripheral-blood-mononuclear-cells-hsa_circ_0005836-as-a-new-diagnostic-biomarker-and-therapeutic-target-of-active-pulmonary-tuberculosis
#12
Ze-Gang Zhuang, Jun-Ai Zhang, Hou-Long Luo, Gan-Bin Liu, Yuan-Bin Lu, Nan-Hai Ge, Bi-Ying Zheng, Rui Xi Li, Chen Chen, Xin Wang, Yu-Qing Liu, Feng-Hui Liu, Yong Zhou, Xiao-Zhen Cai, Zheng W Chen, Jun-Fa Xu
It has been reported that circular RNA (circRNA) is associated with human cancer. However, few studies have been reported in active pulmonary tuberculosis (APTB). The global circRNA expression was detected in the peripheral blood mononuclear cells (PBMCs) of APTB patients (n=5) and health controls (HC) (n=5) by using high-throughput sequencing. According to the systematical bioinformatics analysis, the basic content of circRNAs and their fold changes in the two groups were calculated. We selected 6 significant differentially expressed circRNAs, hsa_circ_0005836, hsa_circ_0009128, hsa_circ_0003519, hsa_circ_0023956, hsa_circ_0078768, and hsa_circ_0088452 and validated the expression in PBMCs from APTB (n=10) and HC (n=10) by real-time quantitative reverse transcription-polymerase chain reactions (qRT-PCRs)...
August 25, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28841370/reversed-phase-high-performance-liquid-chromatography-for-the-quantification-and-optimization-for-extracting-10-kinds-of-carotenoids-in-pepper-capsicum-annuum-l-leaves
#13
Jing Li, Jianming Xie, Jihua Yu, Jian Lv, Junfeng Zhang, Xiaolong Wang, Cheng Wang, Chaonan Tang, Yingchun Zhang, Mohammed Mujitaba Dawuda, Daiqiang Zhu, Guoli Ma
Carotenoids are considered to be crucial elements in many fields and, furthermore, the significant factor in pepper leaves under low light and chilling temperature. However, little literature focused on the method to determinate and extract the contents of carotenoid compositions in pepper leaves. Therefore, a time-saving and highly sensitive reversed-phase high-performance liquid chromatography method for separation and quantification of 10 carotenoids was developed, and an optimized technological process for carotenoid composition extraction in pepper leaves was established for the first time...
September 8, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28840690/-pro-inflammatory-mechanism-of-lectin-from-pinellia-pedatisecta-on-macrophage
#14
Shan-Hu Mao, Hong-Li Yu, Hao Wu, Wei Wang, Xiao-Nan Li
To investigate the mechanism of lectin from Pinellia pedatisecta(PPL) on macrophage-induced inflammation and its association with inflammatory corpuscles NLRP3. Lectin from P. pedatisecta was isolated and purified by gel chromatography, and its purity was analyzed by using SDS-PAGE gel electrophoresis. ELISA was used to investigate the effect of PPL on inflammatory cytokines released by macrophages, with IL-1β as indicators;and fluorescence probe DCFH-DA fluorometer was used to determine changes in active oxygen ROS of macrophages after application of lectin from P...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28839439/outcomes-of-preoperative-endoscopic-nasobiliary-drainage-and-endoscopic-retrograde-biliary-drainage-for-malignant-distal-biliary-obstruction-prior-to-pancreaticoduodenectomy
#15
Guo-Qiang Zhang, Yong Li, Yu-Ping Ren, Nan-Tao Fu, Hai-Bing Chen, Jun-Wu Yang, Wei-Dong Xiao
AIM: To compare the outcomes of preoperative endoscopic nasobiliary drainage (ENBD) and endoscopic retrograde biliary drainage (ERBD) in patients with malignant distal biliary obstruction prior to pancreaticoduodenectomy (PD). METHODS: Data from 153 consecutive patients who underwent preoperative endoscopic biliary drainage prior to PD between January 2009 and July 2016 were analyzed. We compared the clinical data, procedure-related complications of endoscopic biliary drainage (EBD) and postoperative complications of PD between the ENBD and ERBD groups...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28839145/dact1-overexpression-in-type-i-ovarian-cancer-inhibits-malignant-expansion-and-cis-platinum-resistance-by-modulating-canonical-wnt-signalling-and-autophagy
#16
Ruo-Nan Li, Bin Liu, Xue-Mei Li, Liang-Si Hou, Xiao-Ling Mu, Hui Wang, Hua Linghu
Type I epithelial ovarian cancer (EOC) is primarily resistant to platinum-based chemotherapies and needs novel therapeutics. Given the aberrant Wnt activation in type I EOC and the involvement of Dapper1 Antagonist of Catenin-1 (DACT1) in Wnt signalling, the role of DACT1 in tumourigenesis of type I EOC was evaluated. Firstly, all tested EOC cell lines and primary EOC tissues, especially type I EOC, were observed to have significantly lower DACT1 expression than normal controls. Next, 3AO cells, which arise from a patient with primary mucinous EOC and express low endogenous levels of DACT1, were transfected with a lentivirus carrying full-length DACT1 (3AO-DACT1), grew slower and formed smaller tumours in nude mice compared to 3AO-NC...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28836435/controlling-molecular-weight-of-hyaluronic-acid-conjugated-on-amine-rich-surface-toward-better-multifunctional-biomaterials-for-cardiovascular-implants
#17
Jingan Li, Feng Wu, Kun Zhang, Zikun He, Dan Zou, Xiao Luo, Yonghong Fan, Ping Yang, Ansha Zhao, Nan Huang
The molecular weights (MWs) of hyaluronic acid (HA) in extracellular matrix secreted from both vascular endothelial cells (VECs) and vascular smooth muscle cells (VSMCs) play crucial roles in the cardiovascular physiology, as HA with appropriate MW influences important pathways of cardiovascular homeostasis, inhibits VSMC synthetic phenotype change and proliferation, inhibits platelet activation and aggregation, promotes endothelial monolayer repair and functionalization, and prevents inflammation and atherosclerosis...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28831069/theoretical-studies-of-intracellular-concentration-of-micro-organisms-metabolites
#18
Hai-Feng Yang, Xiao-Nan Zhang, Yan Li, Yong-Hong Zhang, Qin Xu, Dong-Qing Wei
With the rapid growth of micro-organism metabolic networks, acquiring the intracellular concentration of microorganisms' metabolites accurately in large-batch is critical to the development of metabolic engineering and synthetic biology. Complementary to the experimental methods, computational methods were used as effective assessing tools for the studies of intracellular concentrations of metabolites. In this study, the dataset of 130 metabolites from E. coli and S. cerevisiae with available experimental concentrations were utilized to develop a SVM model of the negative logarithm of the concentration (-logC)...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827171/the-g-protein-%C3%AE-subunit-agb1-promotes-hypocotyl-elongation-through-inhibiting-transcription-activation-function-of-bbx21-in%C3%A2-arabidopsis
#19
Dong-Bei Xu, Shi-Qing Gao, Ya-Nan Ma, Xiao-Ting Wang, Lu Feng, Lian-Cheng Li, Zhao-Shi Xu, Yao-Feng Chen, Ming Chen, You-Zhi Ma
Hypocotyl development in Arabidopsis thaliana is regulated by light and endogenous hormonal cues, making it an ideal model to study the interplay between light and endogenous growth regulators. BBX21, a B-box (BBX)-like zinc-finger transcription factor, integrates light and abscisic acid signals to regulate hypocotyl elongation in Arabidopsis. Heterotrimeric G-proteins are pivotal regulators of plant development. The short hypocotyl phenotype of the G-protein β-subunit (AGB1) mutant (agb1-2) has been previously identified, but the precise role of AGB1 in hypocotyl elongation remains enigmatic...
September 12, 2017: Molecular Plant
https://www.readbyqxmd.com/read/28819147/nitrogen-starvation-impacts-the-photosynthetic-performance-of-porphyridium-cruentum-as-revealed-by-chlorophyll-a-fluorescence
#20
Long-Sheng Zhao, Kang Li, Qian-Min Wang, Xiao-Yan Song, Hai-Nan Su, Bin-Bin Xie, Xi-Ying Zhang, Feng Huang, Xiu-Lan Chen, Bai-Cheng Zhou, Yu-Zhong Zhang
Nitrogen is one of the most important nutrients needed for plants and algae to survive, and the photosynthetic ability of algae is related to nitrogen abundance. Red algae are unique photosynthetic eukaryotic organisms in the evolution of algae, as they contain phycobilisomes (PBSs) on their thylakoid membranes. In this report, the in vivo chlorophyll (Chl) a fluorescence kinetics of nitrogen-starved Porphyridium cruentum were analyzed to determine the effects of nitrogen deficiency on photosynthetic performance using a multi-color pulse amplitude modulation (PAM) chlorophyll fluorometer...
August 17, 2017: Scientific Reports
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