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Xiao-Nan Li

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https://www.readbyqxmd.com/read/29332411/%C3%AE-1-integrin-mediated-multicellular-resistance-in-hepatocellular-carcinoma-through-activation-of-the-fak-akt-pathway
#1
Tao Tian, Chun-Li Li, Xiao Fu, Shu-Hong Wang, Jun Lu, Hui Guo, Yu Yao, Ke-Jun Nan, Yu-Juan Yang
Objective To explore the role and mechanism of β1 integrin in the regulation of multicellular drug resistance in hepatocellular carcinoma (HCC). Methods This in vitro study used a liquid overlay technique to obtain multicellular spheroids of two human HCC cell lines, HepG2 and Bel-7402. The morphology of the spheroids was observed by optical and electron microscopy. The effects of exposure to 5-fluorouracil (5-FU) and cisplatin (CDDP) on cell proliferation and the induction of apoptosis were assessed in monolayer cells and multicellular spheroids...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29332333/epigallocatechin-gallate-from-green-tea-exhibits-potent-anticancer-effects-in-a-549-non-small-lung-cancer-cells-by-inducing-apoptosis-cell-cycle-arrest-and-inhibition-of-cell-migration
#2
Jie Huang, Shi Chen, Yi Shi, Cheng-Hong Li, Xiao-Jiang Wang, Fa-Jiu Li, Chuan-Hai Wang, Qing-Hua Meng, Jin-Nan Zhong, Min Liu, Zi-Ming Wang
PURPOSE: Green tea (Camellia sinensis) is considered as a rich source of epigallocatechin gallate (EGCG) which has been shown to exert impressive pharmacological properties. The anticancer properties of EGCG have been extensively studied however, its anticancer activity has not been explored in lung cancer. The present study was therefore designed to evaluate the anticancer effects of EGCG against non-small cell lung cancer (NSCLC) cell line A-549 and normal human fibroblast FR-2 cells...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29328989/inhibition-of-udp-glucuronosyltransferases-ugts-by-phthalate-monoesters
#3
Zuo Du, Yun-Feng Cao, Sai-Nan Li, Cui-Min Hu, Zhi-Wei Fu, Chun-Ting Huang, Xiao-Yu Sun, Yong-Zhe Liu, Kun Yang, Zhong-Ze Fang
Phthalate monoesters are important metabolites of phthalate esters (PAEs) which have been extensively utilized in industry. This study aims to investigate the inhibition of phthalate monoesters on the activity of various isoforms of UDP-glucuronosyltransferases (UGTs), trying to elucidate the toxicity mechanism of environmental endocrine disruptors from the new perspectives. In vitro recombinant UGTs-catalyzed glucuronidation of 4-methylumbelliferone (4-MU) was employed to evaluate 8 kinds of phthalate monoesters on 11 sorts of main human UGT isoforms...
January 5, 2018: Chemosphere
https://www.readbyqxmd.com/read/29328448/association-between-ace2-ace-balance-and-pneumocyte-apoptosis-in-a-porcine-model-of-acute-pulmonary-thromboembolism-with-cardiac-arrest
#4
Hong-Li Xiao, Lian-Xing Zhao, Jun Yang, Nan Tong, Le An, Qi-Tong Liu, Miao-Rong Xie, Chun-Sheng Li
Acute pulmonary embolism (APE) is frequently reported in patients with cardiac arrest (CA) in emergency care. Pneumocyte apoptosis is commonly observed in the lungs following an APE. An important pathological mechanism evoking apoptosis during a lipopolysaccharide‑induced acute lung injury is the angiotensin‑converting enzyme 2 (ACE2)/ACE imbalance. The present study uses a porcine model to examine the anti‑apoptotic effects of captopril on APE‑CA and the return of spontaneous circulation (ROSC). Pigs were randomly assigned into four groups: Control, APE‑CA, ROSC‑saline, and ROSC‑captopril...
January 12, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29326194/association-of-erythrocyte-parameters-with-metabolic-syndrome-in-the-pearl-river-delta-region-of-china-a-cross-sectional-study
#5
Ling Ling Huang, Dong-Mei Dou, Nan Liu, Xiao Xiao Wang, Li-Ying Fu, Xiao Wu, Peixi Wang
OBJECTIVE: Increasing studies have reported that erythrocyte parameters, including red blood cells (RBCs), haematocrit (HCT), haemoglobin (Hb) and red blood cell distribution width (RDW), are associated with metabolic syndrome (MetS) in adults worldwide. However, the association, stratified by sex, remains to be elucidated, particularly in the Pearl River Delta region of China. Therefore, our aim was to explore the association of erythrocyte parameters with MetS, stratified by sex, in the Pearl River Delta region of China...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29321004/rcc2-over-expression-in-tumor-cells-alters-apoptosis-and-drug-sensitivity-by-regulating-rac1-activation
#6
Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin, Sheng Xiao
BACKGROUND: Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be blocked by regulator of chromosome condensation 2 (RCC2), which binds the switch regions of Rac1 to prevent access from GEFs. METHODS: Three cancer cell lines with up- or down-regulation of RCC2 were used to evaluate cell proliferation, apoptosis, Rac1 signaling and sensitivity to a group of nine chemotherapeutic drugs...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29312605/overexpression-of-scamp3-is-an-indicator-of-poor-prognosis-in-hepatocellular-carcinoma
#7
Xinyuan Zhang, Jie Sheng, Yuhong Zhang, Yu Tian, Jie Zhu, Nan Luo, Congshu Xiao, Rongkuan Li
SCAMP3, an isoform of the secretory carrier membrane proteins (SCAMPs) family, is a membrane-trafficking protein involved in endosome transport. Previous microarray data showed that SCAMP3 mRNA is highly expressed in hepatocellular carcinoma (HCC). In this study, the expression and clinical significance of SCAMP3 in 100 pairs of HCC and adjacent normal tissue were investigated. siRNA transfection was performed to silence SCAMP3 expression in HCC cells. The MTS assay and flow cytometry were used to detect the proliferation, cell cycle progression of HCC cells...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29311543/heisenberg-scaling-measurement-of-the-single-photon-kerr-non-linearity-using-mixed-states
#8
Geng Chen, Nati Aharon, Yong-Nan Sun, Zi-Huai Zhang, Wen-Hao Zhang, De-Yong He, Jian-Shun Tang, Xiao-Ye Xu, Yaron Kedem, Chuan-Feng Li, Guang-Can Guo
Improving the precision of measurements is a significant scientific challenge. Previous works suggest that in a photon-coupling scenario the quantum fisher information shows a quantum-enhanced scaling of N2, which in theory allows a better-than-classical scaling in practical measurements. In this work, utilizing mixed states with a large uncertainty and a post-selection of an additional pure system, we present a scheme to extract this amount of quantum fisher information and experimentally attain a practical Heisenberg scaling...
January 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29310434/in-vitro-and-in-vivo-studies-on-biomedical-magnesium-low-alloying-with-elements-gadolinium-and-zinc-for-orthopaedic-implant-applications
#9
Dong Bian, Jiuxu Deng, Nan Li, Xiao Chu, Yang Liu, Wenting Li, Hong Cai, Peng Xiu, Yu Zhang, Zhenpeng Guan, Yufeng Zheng, Yuhui Kou, Baoguo Jiang, Rongshi Chen
Ternary magnesium alloys with low combined-addition of elements gadolinium and zinc were developed in the present work, with their microstructures, mechanical properties, in vitro degradation behaviors and cytotoxicity being systematically studied. Furthermore, Mg-1.8Zn-0.2Gd alloy, with the best in vitro performances, was implanted into Sprague Dawley rats to examine its in vivo degradation performances up to 6 months. It was found that Mg-1.8Zn-0.2Gd, composed of single α-Mg phase, owned excellent strength and toughness that were comparable to the CE marked MAGNEZIX®, the mischmetal added Mg alloy...
January 9, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29299573/gallic-acid-assisted-synthesis-of-pd-uniformly-anchored-on-porous-n-rgo-as-efficient-electrocatalyst-for-microbial-fuel-cells
#10
Xiao-Tong Wu, Jie-Cheng Li, Qiu-Ren Pan, Nan Li, Zhao-Qing Liu
The sluggish kinetic rate-limiting oxygen reduction reaction (ORR) at the cathode remains the foremost issue hindering the commercialization of microbial fuel cells (MFCs). Utilization of the effect of micromolecule conjugation and the synergistic effect between Pd nanoparticles and N-rGO (nitrogen-doped reduced graphene oxide) to stabilize a precious metal onto carbon materials is a promising strategy to design and synthesize highly efficient cathode catalysts. In this study, gallic acid is used to facilitate the coupling of palladium (Pd) with N-rGO to form GN@Pd-GA via a simple hydrothermal process...
January 4, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29298352/the-safety-and-efficacy-of-hybrid-ablation-for-the-treatment-of-atrial-fibrillation-a-meta-analysis
#11
Yun-Qiu Jiang, Ying Tian, Li-Jun Zeng, Shu-Nan He, Zhi-Tao Zheng, Liang Shi, Yan-Jiang Wang, Yu-Xing Wang, Xian-Dong Yin, Xiao-Qing Liu, Xin-Chun Yang, Xing-Peng Liu
INTRODUCTION: Hybrid ablation, an emerging therapy that combines surgical intervention and catheter ablation, has become a viable option for the treatment of persistent atrial fibrillation. In this analysis, we aimed to evaluate the safety and efficacy of hybrid ablation, as well as compare the outcomes of one-step and staged approaches. METHODS: We conducted a search in major online databases and selected the studies that met the inclusion criteria. The primary endpoint was defined as no episode of atrial fibrillation or atrial tachycardia lasting longer than 30 seconds without administration of antiarrhythmic drugs...
2018: PloS One
https://www.readbyqxmd.com/read/29291438/synthesis-and-antidepressant-like-activity-of-novel-aralkyl-piperazine-derivatives-targeting-ssri-5-ht1a-5-ht7
#12
Zheng-Song Gu, Ai-Nan Zhou, Ying Xiao, Qing-Wei Zhang, Jian-Qi Li
A series of novel aralkyl piperazine derivatives were synthesized, and evaluated for their serotonin reuptake inhibitory and 5-HT1A/5-HT7 receptors affinities activity. Antidepressant activities in vivo of the compounds were screened using the forced swimming test (FST) and tail suspension test (TST). The results indicated that compounds 21k (RUI, IC50 = 31 nM; 5-HT1A, 5-HT7, ki = 62, 12 nM) and 21n (RUI, IC50 = 25 nM; 5-HT1A, 5-HT7, ki = 28, 3.3 nM) exhibited high affinities for the 5-HT1A/5-HT7 receptors coupled with potent serotonin reuptake inhibition...
December 20, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29289655/construction-immune-protection-and-innate-immune-response-of-shuffled-polyvalent-ompas-vaccines
#13
Sheng-Nan Wang, Zhi-Xue Cheng, Xiao-Peng Ling, Xiao Chu, Xuan-Xian Peng, Hui Li
Our previous studies demonstrated that molecular breeding via DNA shuffling directs the evolution of polyvalent vaccines with desired traits, which leads to generation of polyvalent ompA vaccines using Vibrio alginolyticus VA0764 primers. Here, we replaced VA0764 primers with Edwardsiella tarda ompA primers to generate new polyvalent ompA vaccines by DNA shuffling of the same five ompA genes from four species of bacteria E. tarda, V. parahaemolyticus, V. alginolyticus and Escherichia coli. We identified four polyvalent vaccine candidates from a eukaryotic expressing library EompAs-FE containing 82 ompAs using active immune protection against V...
December 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29285673/detection-isolation-and-characterization-of-chikungunya-viruses-associated-with-the-pakistan-outbreak-of-2016-2017
#14
Si-Qing Liu, Xiao Li, Ya-Nan Zhang, Ai-Li Gao, Cheng-Lin Deng, Jun-Hua Li, Shoukat Jehan, Nadia Jamil, Fei Deng, Hongping Wei, Bo Zhang
The chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus, which has infected millions of people in Africa, Asia, Americas, and Europe since it reemerged in India and Indian Ocean regions in 2005-2006. Starting in the middle of November 2016, CHIKV has been widely spread, and more than 4,000 cases of infections in humans were confirmed in Pakistan. Here, we report the first isolation and characterization of CHIKV from the Pakistan outbreak. Eight CHIKV strains were newly isolated from human serum samples using a cell culture procedure...
December 21, 2017: Virologica Sinica
https://www.readbyqxmd.com/read/29274415/the-activation-and-function-of-il-36%C3%AE-in-neutrophilic-inflammation-in-chronic-rhinosinusitis
#15
Hai Wang, Zhi-Yong Li, Wen-Xiu Jiang, Bo Liao, Guan-Ting Zhai, Nan Wang, Zhen Zhen, Jian-Wen Ruan, Xiao-Bo Long, Heng Wang, Wei-Hong Liu, Geng-Tian Liang, Wei-Min Xu, Atsushi Kato, Zheng Liu
BACKGROUND: Although increased accumulation of neutrophils has been noted in chronic rhinosinusitis (CRS), the function and regulation of neutrophils in CRS are largely unknown. IL-36 family cytokines may play an important role in neutrophilic inflammation. OBJECTIVE: To investigate the expression and function of IL-36 cytokines in CRS. METHODS: Quantitative RT-PCR, immunohistochemistry, immunofluorescence, and ELISA were used to investigate the expression of IL-36 cytokines and IL-36 receptor (IL-36R) in sinonasal mucosa...
December 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29260818/synthesis-and-structural-characterization-of-alkali-metal-arsinoamides
#16
Xiao Chen, Michael T Gamer, Peter W Roesky
The aminoarsane Mes2AsN(H)Ph was prepared from Mes2AsCl and aniline in good yields. Deprotonation of Mes2AsN(H)Ph with suitable alkali metal bases resulted in the corresponding alkali metal derivatives. Thus, reaction of Mes2AsN(H)Ph with nBuLi, NaN(SiMe3)2, or KH gave the metal complexes [(Mes2AsNPh){Li(OEt2)2}], [(Mes2AsNPh){Na(OEt2)}]2, and [(Mes2AsNPh){K(THF)}]2. These are the first metal complexes ligated by an arsinoamide. All solid-state structures were established by single crystal X-ray diffraction...
December 20, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29260585/intraoperative-visualisation-of-functional-structures-facilitates-safe-frameless-stereotactic-biopsy-in-the-motor-eloquent-regions-of-the-brain
#17
Jia-Shu Zhang, Ling Qu, Qun Wang, Wei Jin, Yuan-Zheng Hou, Guo-Chen Sun, Fang-Ye Li, Xin-Guang Yu, Ban-Nan Xu, Xiao-Lei Chen
BACKGROUND: For stereotactic brain biopsy involving motor eloquent regions, the surgical objective is to enhance diagnostic yield and preserve neurological function. To achieve this aim, we implemented functional neuro-navigation and intraoperative magnetic resonance imaging (iMRI) into the biopsy procedure. The impact of this integrated technique on the surgical outcome and postoperative neurological function was investigated and evaluated. METHOD: Thirty nine patients with lesions involving motor eloquent structures underwent frameless stereotactic biopsy assisted by functional neuro-navigation and iMRI...
December 20, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29250126/polydatin-protects-rat-liver-against-ethanol-induced-injury-involvement-of-cyp2e1-ros-nrf2-and-tlr4-nf-%C3%AE%C2%BAb-p65-pathway
#18
Qiong-Hui Huang, Lie-Qiang Xu, Yu-Hong Liu, Jia-Zhen Wu, Xue Wu, Xiao-Ping Lai, Yu-Cui Li, Zi-Ren Su, Jian-Nan Chen, You-Liang Xie
Excessive alcohol consumption leads to serious liver injury, associating with oxidative stress and inflammatory response. Previous study has demonstrated that polydatin (PD) exerted antioxidant and anti-inflammatory effects and attenuated ethanol-induced liver damage, but the research remained insufficient. Hence, this experiment aimed to evaluate the hepatoprotective effect and potential mechanisms of PD on ethanol-induced hepatotoxicity. Our results showed that PD pretreatment dramatically decreased the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in the serum, suppressed the malonaldehyde (MDA) and triglyceride (TG) content and the production of reactive oxygen species (ROS), and enhanced the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), andalcohol dehydrogenase (ADH), and aldehyde dehydrogenase (ALDH), paralleled by an improvement of histopathology alterations...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29247526/effects-of-shrna-mediated-silencing-of-psma7-on-cell-proliferation-and-vascular-endothelial-growth-factor-expression-via-the-ubiquitin-proteasome-pathway-in-cervical-cancer
#19
Chen-Chen Ren, Li Yang, Ling Liu, Yan-Nan Chen, Guo-Mei Cheng, Xiao-An Zhang, Hui Liu
This study aims to evaluate the effects of PSMA7 silencing on cervical cancer (CC) cell proliferation and vascular endothelial growth factor (VEGF) expression through the ubiquitin-proteasome (UPP) pathway. CC tissue (n = 43) and normal tissues (n = 27) were first collected from patients. Human CC cell line (SiHa) and human normal cervical epithelial cells (H8) were obtained and classified into the normal, blank, negative control (NC), PSMA7-shRNA1 and PSMA7-shRNA2 groups. Hybridization in situ was used to detect the expressions of wild-type and mutant p53 proteins...
December 16, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29245938/mir-195-suppresses-the-metastasis-and-epithelial-mesenchymal-transition-of-hepatocellular-carcinoma-by-inhibiting-yap
#20
Shuo Yu, Li Jing, Xiao-Ran Yin, Min-Cong Wang, Yi-Meng Chen, Ya Guo, Ke-Jun Nan, Li-Li Han
MiR-195, a novel cancer-related microRNA, was previously reported to play an important role in many malignancies. This study aimed to investigate the role of miR-195 mediated epithelial-mesenchymal transition (EMT) and the progression of hepatocellular carcinoma (HCC) as well as the underlying mechanisms. Our result demonstrated that miR-195 were significantly down regulated in HCC and its decreased expression is associated with poor clinical features of HCC patients. Oppositely, expression level of YAP was significantly higher in HCC tissues, and the level of YAP in metastatic tissues was significantly higher...
November 21, 2017: Oncotarget
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