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Xiao-Nan Li

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https://www.readbyqxmd.com/read/28718622/graphene-sheet-induced-global-maturation-of-cardiomyocytes-derived-from-human-induced-pluripotent-stem-cells
#1
Jiaxian Wang, Chang Cui, Haiyan Nan, Yuanfang Yu, Yini Xiao, Ellen Poon, Gang Yang, Xijie Wang, Chenchen Wang, Lingsong Li, Kenneth Richard Boheler, Xu Ma, Xin Cheng, Zhenhua Ni, Minglong Chen
Human induced pluripotent stem cells (hiPSCs) can proliferate infinitely. Their ability to differentiate into cardiomyocytes provides abundant sources for disease modeling, drug screening and regenerative medicine. However, hiPSC-derived cardiomyocytes (hiPSC-CMs) display a low degree of maturation and fetal-like properties. Current in vitro differentiation methods do not mimic the structural, mechanical, and physiological properties of the cardiogenesis niche. Recently, we present an efficient cardiac maturation platform that combines hiPSCs monolayer cardiac differentiation with graphene substrate which is a biocompatible and superconductive material...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28711905/the-prevalence-subtypes-and-associated-factors-of-hyperuricemia-in-lupus-nephritis-patients-at-chronic-kidney-disease-stages-1-3
#2
Simeng Liu, Yijun Gong, Hong Ren, Wen Zhang, Xiaonong Chen, Tong Zhou, Xiao Li, Nan Chen
There is a high prevalence of hyperuricemia (HUA) in the chronic kidney disease (CKD) population. However, there's a dearth of research on HUA's prevalence, subtypes, early detection, and treatment strategies of HUA in lupus nephritis (LN) patients. The aim of this study is to address these knowledge gaps. LN patients presenting to the Department of Nephrology at Shanghai Rui Jin Hospital from January 2011 to January 2016 were recruited. The effective sample size was derived using the power analysis. The demographic, clinical and laboratory characteristics of the LN patients with HUA were compared with those of patients without HUA...
July 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28709040/low-concentrations-of-bisphenol-a-promote-human-ovarian-cancer-cell-proliferation-and-glycolysis-based-metabolism-through-the-estrogen-receptor-%C3%AE-pathway
#3
Xiao-Yu Shi, Zhe Wang, Liyu Liu, Li-Min Feng, Nan Li, Sijin Liu, Hui Gao
Bisphenol A (BPA) is one of the most prevalent chemicals in many products used on a daily basis, making human exposure to it incredibly pervasive and raising concerns about its health consequences. One area of research focus has been the role of BPA exposure in promoting the development of ovarian cancer; however, the doses used in most of previous studies are relatively high and most likely exceed physiologically relevant levels. At the same time, few studies have described potential mechanisms underlying the link between BPA and increased cancer risk...
July 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28708163/compact-tunable-photonic-comb-filter-on-a-silicon-platform
#4
Shuang Zheng, Nan Zhou, Yun Long, Zhengsen Ruan, Jing Du, Xiao Hu, Li Shen, Shuhui Li, Jian Wang
We propose and demonstrate a compact wavelength- and bandwidth-tunable photonic comb filter on a silicon platform. It is a Fabry-Perot (FP) cavity fabricated on silicon-on-insulator, which is composed of two cascaded Sagnac loop mirrors (SLMs) with multimode-interferometer-assisted Mach-Zehnder interferometer (MZI) couplers. The effective length of the FP cavity and the reflectivity of the SLMs can be dynamically changed based on thermal-optical effects by tuning three phase shifters along the cavity length and MZI arms, leading to center wavelength tuning and bandwidth tuning of the comb filter...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28700999/genome-wide-association-study-of-mki67-expression-and-its-clinical-implications-in-hbv-related-hepatocellular-carcinoma-in-southern-china
#5
Cheng-Kun Yang, Ting-Dong Yu, Chuang-Ye Han, Wei Qin, Xi-Wen Liao, Long Yu, Xiao-Guang Liu, Guang-Zhi Zhu, Hao Su, Si-Cong Lu, Zhi-Wei Chen, Zhen Liu, Ke-Tuan Huang, Zheng-Tao Liu, Yu Liang, Jian-Lu Huang, Zeng-Nan Mo, Xue Qin, Lequn Li, Kai-Yin Xiao, Min-Hao Peng, Cheryl Ann Winkle, Stephen J O'Brien, Tao Peng
BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a common malignant tumor with a high rate of recurrence. Immunohistochemical analysis of the marker of proliferation Ki-67 (MKI67) is used to assess proliferation activity of HCC The regulation of MKI67 expression remains unclear in HCC This study aims to explore the association between MKI67 expression and gene variants. METHODS: A total of 195 hepatitis B virus (HBV)-related HCC patients were genotyped using Illumina HumanExome BeadChip-12-1_A (242,901 markers)...
July 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28700471/plasma-cytokines-can-help-to-identify-the-development-of-severe-acute-pancreatitis-on-admission
#6
Li-Hui Deng, Cheng Hu, Wen-Hao Cai, Wei-Wei Chen, Xiao-Xin Zhang, Na Shi, Wei Huang, Yun Ma, Tao Jin, Zi-Qi Lin, Kun Jiang, Jia Guo, Xiao-Nan Yang, Qing Xia
Severe acute pancreatitis (AP) is associated with high morbidity and mortality. Early severity stratification remains a challenging issue to overcome to improve outcomes. We aim to find novel plasma cytokines for the early identification of severe AP according to the revised Atlanta criteria.In this prospective observational study, 30 cytokines, screened semiquantitatively with a human multicytokine array, were submitted to quantitative determination using either microparticle-based multiplex immunoassays analyzed on a Luminex 100 platform or enzyme-linked immunosorbent assay kits...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28689798/ethyl-acetate-extract-from-panax-ginseng-c-a-meyer-and-its-main-constituents-inhibit-%C3%AE-melanocyte-stimulating-hormone-induced-melanogenesis-by-suppressing-oxidative-stress-in-b16-mouse-melanoma-cells
#7
Rui Jiang, Xiao-Hao Xu, Ke Wang, Xin-Zhao Yang, Ying-Fei Bi, Yao Yan, Jian-Zeng Liu, Xue-Nan Chen, Zhen-Zhong Wang, Xiao-Li Guo, Da-Qing Zhao, Li-Wei Sun
ETHNOPHARMACOLOGICAL RELEVANCE: Hyperpigmentation disease involves darkening of the skin color due to melanin overproduction. Panax ginseng C.A. Meyer is a well-known traditional Chinese medicine and has a long history of use as a skin lightener to inhibit melanin formation in China, Korea and some other Asian countries. However, the constituents and the molecular mechanisms by which they affect melanogenesis are not fully clear. AIM OF THE STUDY: The purpose of this study was to identify the active ingredient in Panax ginseng C...
July 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28689797/pudilan-xiaoyan-oral-liquid-alleviates-lps-induced-respiratory-injury-through-decreasing-nitroxidative-stress-and-blocking-tlr4-activation-along-with-nf-%C3%AE-b-phosphorylation-in-mice
#8
Liang Feng, Nan Yang, Chao Li, Gang Tian, Jing Wang, Zi-Bo Dong, Xiao-Bin Jia, Liu-Qing Di
ETHNOPHARMACOLOGICAL RELEVANCE: Pudilan xiaoyan oral liquid (PDL), collected in Chinese Pharmacopoeia, has been used clinically for treating inflammatory diseases such as upper respiratory tract infection diseases. However, its potential anti-inflammation and the mechanism are still unclear. MATERIALS AND METHODS: lipopolysaccharide (LPS) was used to induce respiratory inflammation of mice by intratracheal administration. UPLC/MS was performed for components analysis of PDL...
July 6, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28680059/gwas-follow-up-study-of-esophageal-squamous-cell-carcinoma-identifies-potential-genetic-loci-associated-with-family-history-of-upper-gastrointestinal-cancer
#9
Xin Song, Wen-Qing Li, Nan Hu, Xue Ke Zhao, Zhaoming Wang, Paula L Hyland, Tao Jiang, Guo Qiang Kong, Hua Su, Chaoyu Wang, Lemin Wang, Li Sun, Zong Min Fan, Hui Meng, Tang Juan Zhang, Ling Fen Ji, Shou Jia Hu, Wei Li Han, Min Jie Wu, Peng Yuan Zheng, Shuang Lv, Xue Min Li, Fu You Zhou, Laurie Burdett, Ti Ding, You-Lin Qiao, Jin-Hu Fan, Xiao-You Han, Carol Giffen, Margaret A Tucker, Sanford M Dawsey, Neal D Freedman, Stephen J Chanock, Christian C Abnet, Philip R Taylor, Li-Dong Wang, Alisa M Goldstein
Based on our initial genome-wide association study (GWAS) on esophageal squamous cell carcinoma (ESCC) in Han Chinese, we conducted a follow-up study to examine the single nucleotide polymorphisms (SNPs) associated with family history (FH) of upper gastrointestinal cancer (UGI) cancer in cases with ESCC. We evaluated the association between SNPs and FH of UGI cancer among ESCC cases in a stage-1 case-only analysis of the National Cancer Institute (NCI, 541 cases with FH and 1399 without FH) and Henan GWAS (493 cases with FH and 869 without FH) data (discovery phase)...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28677365/prognostic-value-of-long-non-coding-rna-uca1-in-digestive-system-malignancies
#10
Ning Song, Hui Zhai, Xiao-Mei Li, Qing-Jie Chen, Guang-Nan Huang, Fen Liu, Yi-Ning Yang
No abstract text is available yet for this article.
August 2017: Minerva Medica
https://www.readbyqxmd.com/read/28670162/the-blood-oxygenation-t2-values-of-resectable-esophageal-squamous-cell-carcinomas-as-measured-by-3t-magnetic-resonance-imaging-association-with-tumor-stage
#11
Yu-Lian Tang, Xiao-Ming Zhang, Zhi-Gang Yang, Yu-Cheng Huang, Tian-Wu Chen, Yan-Li Chen, Fan Chen, Nan-Lin Zeng, Rui Li, Jiani Hu
OBJECTIVE: To explore the association between the blood oxygenation T2(*) values of resectable esophageal squamous cell carcinomas (ESCCs) and tumor stages. MATERIALS AND METHODS: This study included 48 ESCC patients and 20 healthy participants who had undergone esophageal T2(*)-weighted imaging to obtain T2(*) values of the tumors and normal esophagi. ESCC patients underwent surgical resections less than one week after imaging. Statistical analyses were performed to identify the association between T2(*) values of ESCCs and tumor stages...
July 2017: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/28669244/automated-detector-of-high-frequency-oscillations-in-epilepsy-based-on-maximum-distributed-peak-points
#12
Guo-Ping Ren, Jia-Qing Yan, Zhi-Xin Yu, Dan Wang, Xiao-Nan Li, Shan-Shan Mei, Jin-Dong Dai, Xiao-Li Li, Yun-Lin Li, Xiao-Fei Wang, Xiao-Feng Yang
High frequency oscillations (HFOs) are considered as biomarker for epileptogenicity. Reliable automation of HFOs detection is necessary for rapid and objective analysis, and is determined by accurate computation of the baseline. Although most existing automated detectors measure baseline accurately in channels with rare HFOs, they lose accuracy in channels with frequent HFOs. Here, we proposed a novel algorithm using the maximum distributed peak points method to improve baseline determination accuracy in channels with wide HFOs activity ranges and calculate a dynamic baseline...
April 17, 2017: International Journal of Neural Systems
https://www.readbyqxmd.com/read/28667794/oral-administration-of-polaprezinc-attenuates-fluorouracil-induced-intestinal-mucositis-in-a-mouse-model
#13
Zhaoyang Liu, Wenbo Xie, Mingru Li, Nan Teng, Xiao Liang, Ziqiang Zhang, Zhaogang Yang, Xiaobing Wang
5-fluorouracil (5-FU) has broadly been applied to treat colorectal cancer as one of the most effective chemotherapeutic agents. However, it frequently causes intestinal mucosal injury and related side effects, such as abdominal pain and diarrhoea, which limit the use of 5-FU in a clinic setting. Polaprezinc has gradually become known as a mucosal protective agent for the management of gastric ulcer. This study aimed to investigate the prophylactic efficacy of Polaprezinc administered orally against intestinal mucositis induced by 5-FU in mice on the condition that the anti-tumour effect could not be compromised...
July 1, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28667286/abo-blood-type-correlates-with-survival-in-hepatocellular-carcinoma-following-hepatectomy
#14
Tao Wu, Xiao-An Ma, Guo-Qing Wang, Qing Li, Miao-Jing Li, Jin-Yue Guo, Xuan Liang, Zhi-Ping Ruan, Tao Tian, Ke-Jun Nan, Li-Na Liu, Hui Guo
ABO blood types are associated with the prognosis of several malignancies. However, the role of the ABO blood type in hepatocellular carcinoma (HCC) remains elusive. Here, we evaluated the prognostic role of the ABO blood group in 691 HCC patients after hepatectomy by Cox regression analysis. A prognostic nomogram was generated to predict the 3 and 5-year overall survival (OS). A total of 262 HCC patients (37.9%) had blood group O, 199 (28.8%) had blood group A, 165 (23.9%) had blood group B, and 65 (9.4%) had blood group AB...
June 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28665943/anaplastic-lymphoma-kinase-positive-large-b-cell-lymphoma-clinico-pathological-study-of-17-cases-with-review-of-literature
#15
Xiang-Nan Jiang, Bao-Hua Yu, Wei-Ge Wang, Xiao-Yan Zhou, Xiao-Qiu Li
We retrospectively analysed 17 cases of anaplastic lymphoma kinase-positive large B-cell lymphoma (ALK+, LBCL) according to the morphological, immunohistochemical, molecular and clinical features, using which we intend to elucidate the clinicopathological characteristics of this rare entity. In this study, all cases de facto share common features that defined them as a single entity, and various characteristics may expand the spectrum. Among 15 cases, 60% followed an aggressive clinical course with advanced stage and high IPI scores; the median survival of these patients was only 8 months...
2017: PloS One
https://www.readbyqxmd.com/read/28665696/association-analysis-of-single-nucleotide-polymorphisms-in-c1qtnf6-rac2-and-an-intergenic-region-at-14q32-2-with-graves-disease-in-chinese-han-population
#16
Xiao-Hong Zhang, Min Shen, Lin Liu, Fa-Mei Li, Peng-Chen Hu, Qi Hua, Jing Zhang, Li-Nan Pang, Hong-Wen Lu, Zhi-Min Wang, Xun Chu, Wei Huang
BACKGROUND: Variation within C1QTNF6 at 22q12.3, RAC2 at 22q13.1, and an intergenic region at 14q32.2 was found in association with risk to Graves' disease (GD) in a recent study. We aimed to validate these associations with GD in an independent sample set of Han Chinese population. METHODS: We investigated these associations by genotyping three most significantly associated single nucleotide polymorphisms (SNPs) located in these three regions. Rs1456988 within the intergenic region at 14q32...
June 30, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28664164/public-attitudes-toward-gene-therapy-in-china
#17
REVIEW
Jiang-Hui Wang, Rong Wang, Jia Hui Lee, Tiara W U Iao, Xiao Hu, Yu-Meng Wang, Lei-Lei Tu, Yi Mou, Wen-Li Zhu, Ai-Yong He, Shen-Yu Zhu, Di Cao, Lei Yang, Xiao-Bo Tan, Qing Zhang, Guan-Lu Liang, Shu-Min Tang, Ye-Di Zhou, Li-Jun Feng, Li-Jun Zhan, Nan-Nan Tian, Ming-Jie Tang, Ya-Ping Yang, Moeen Riaz, Peter van Wijngaarden, Gregory J Dusting, Guei-Sheung Liu, Yan He
No abstract text is available yet for this article.
September 15, 2017: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/28659514/adsorption-characteristic-of-as-iii-on-goethite-waste-generated-from-hydrometallurgy-of-zinc
#18
Jian-Long Hu, Xiao-Song Yang, Ting Liu, Li-Nan Shao, Wang Zhang
In this paper, goethite waste from hydrometallurgy of zinc was used as a raw material for arsenic adsorbent preparation. The goethite waste adsorbent (GWA) was characterized with scanning electron microscope (SEM), X-ray powder diffraction (XRD), and particle size distribution analysis. The adsorption of As(III) on GWA was studied as a function of contact time, pH, and coexisting anions. The safety of GWA usage in the wastewater treatment process was assessed by toxicity characteristic leaching procedure (TCLP) tests...
June 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28657498/synthesis-and-characterization-of-a-rosmarinic-acid-derivative-that-targets-mitochondria-and-protects-against-radiation-induced-damage-in-vitro
#19
Yu-Rui Zhang, Yuan-Yuan Li, Jun-Ying Wang, Hua-Wei Wang, Hua-Nan Wang, Xiao-Meng Kang, Wen-Qing Xu
Mitochondrial dysfunction plays an important role in gamma-radiation-induced mediating oxidative stress. Scavenging radiation-induced reactive oxygen species (ROS) can help mitochondria to maintain their physiological function. Rosmarinic acid is a polyphenol antioxidant that can scavenge radiation-induced ROS, but the structure prevents it from accumulating in mitochondria. In this study, we designed and synthesized a novel rosmarinic acid derivative (Mito-RA) that could use the mitochondrial membrane potential to enter the organelle and scavenge ROS...
June 28, 2017: Radiation Research
https://www.readbyqxmd.com/read/28653957/the-lifecycle-of-the-ebola-virus-in-host-cells
#20
REVIEW
Dong-Shan Yu, Tian-Hao Weng, Xiao-Xin Wu, Frederick X C Wang, Xiang-Yun Lu, Hai-Bo Wu, Nan-Ping Wu, Lan-Juan Li, Hang-Ping Yao
Ebola haemorrhagic fever causes deadly disease in humans and non-human primates resulting from infection with the Ebola virus (EBOV) genus of the family Filoviridae. However, the mechanisms of EBOV lifecycle in host cells, including viral entry, membrane fusion, RNP formation, GP-tetherin interaction, and VP40-inner leaflet association remain poorly understood. This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle...
June 15, 2017: Oncotarget
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