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https://www.readbyqxmd.com/read/25297911/linagliptin-an-update-of-its-use-in-patients-with-type-2-diabetes-mellitus
#1
REVIEW
Kate McKeage
Linagliptin (Trajenta(®), Tradjenta(®)) is a dipeptidyl peptidase (DPP)-4 inhibitor approved for the treatment of adults with type 2 diabetes mellitus in several countries. A fixed-dose combination of linagliptin/metformin (Jentadueto(®)) is also available. This article reviews the pharmacology, therapeutic efficacy and tolerability of linagliptin in the management of type 2 diabetes, with the aim of updating its place in therapy based on recently published data. In randomized, controlled trials, oral linagliptin 5 mg once daily (or 2...
October 2014: Drugs
https://www.readbyqxmd.com/read/22913735/linagliptin-a-review-of-its-use-in-the-management-of-type-2-diabetes-mellitus
#2
REVIEW
Emma D Deeks
Linagliptin (Trajenta®, Tradjenta™, Trazenta™, Trayenta™) is an oral, highly selective inhibitor of dipeptidyl peptidase-4 and is the first agent of its class to be eliminated predominantly via a nonrenal route. Linagliptin is indicated for once-daily use for the treatment of adults with type 2 diabetes mellitus, and a twice-daily fixed-dose combination of linagliptin/metformin (Jentadueto®) is also available. In this article, the pharmacological, clinical efficacy and tolerability data relevant to the use of linagliptin in patients with type 2 diabetes are reviewed...
September 10, 2012: Drugs
https://www.readbyqxmd.com/read/22761701/linagliptin-improves-insulin-sensitivity-and-hepatic-steatosis-in-diet-induced-obesity
#3
Matthias Kern, Nora Klöting, Heiko G Niessen, Leo Thomas, Detlef Stiller, Michael Mark, Thomas Klein, Matthias Blüher
Linagliptin (TRADJENTA™) is a selective dipeptidyl peptidase-4 (DPP-4) inhibitor. DPP-4 inhibition attenuates insulin resistance and improves peripheral glucose utilization in humans. However, the effects of chronic DPP-4 inhibition on insulin sensitivity are not known. The effects of long-term treatment (3-4 weeks) with 3 mg/kg/day or 30 mg/kg/day linagliptin on insulin sensitivity and liver fat content were determined in diet-induced obese C57BL/6 mice. Chow-fed animals served as controls. DPP-4 activity was significantly inhibited (67-89%) by linagliptin (P<0...
2012: PloS One
https://www.readbyqxmd.com/read/22420306/linagliptin-a-novel-methylxanthin-based-approved-dipeptidyl-peptidase-4-inhibitor
#4
REVIEW
Ritesh Agrawal, Pratima Jain, S N Dikshit
Chemically, methylxanthine nucleus based Linagliptin (BI-1356, BI-1356-BS) is a dipeptidyl peptidase-IV inhibitor, which has been developed by Boehringer Ingelheim in association with Lilly for the treatment of Type-II Diabetes. Linagliptin was marketed by Lilly under the trade name Tradjenta and Trajenta. Linagliptin was approved as the once-daily dose by USFDA on 2 May 2011, for the treatment of Type-II Diabetes. Linagliptin 5mg once daily dose was approved based on a clinical trial program, which was conducted on approximately 4,000 adults with Type-II Diabetes...
June 2012: Current Drug Targets
https://www.readbyqxmd.com/read/22346314/efficacy-and-safety-of-linagliptin-tradjenta-in-adults-with-type-2-diabetes-mellitus
#5
Maisha Kelly Freeman
No abstract text is available yet for this article.
December 2011: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/21701440/linagliptin-tradjenta-a-new-dpp-4-inhibitor-for-type-2-diabetes
#6
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 27, 2011: Medical Letter on Drugs and Therapeutics
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