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https://www.readbyqxmd.com/read/27911782/egfr-signaling-is-critical-for-maintaining-the-superficial-layer-of-articular-cartilage-and-preventing-osteoarthritis-initiation
#1
Haoruo Jia, Xiaoyuan Ma, Wei Tong, Basak Doyran, Zeyang Sun, Luqiang Wang, Xianrong Zhang, Yilu Zhou, Farid Badar, Abhishek Chandra, X Lucas Lu, Yang Xia, Lin Han, Motomi Enomoto-Iwamoto, Ling Qin
Osteoarthritis (OA) is the most common joint disease, characterized by progressive destruction of the articular cartilage. The surface of joint cartilage is the first defensive and affected site of OA, but our knowledge of genesis and homeostasis of this superficial zone is scarce. EGFR signaling is important for tissue homeostasis. Immunostaining revealed that its activity is mostly dominant in the superficial layer of healthy cartilage but greatly diminished when OA initiates. To evaluate the role of EGFR signaling in the articular cartilage, we studied a cartilage-specific Egfr-deficient (CKO) mouse model (Col2-Cre EgfrWa5/flox)...
November 28, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27904568/meta-analysis-of-studies-comparing-adjuvant-dexamethasone-to-glycerol-to-improve-clinical-outcome-of-bacterial-meningitis
#2
REVIEW
Siavash Vaziri, Fiezollah Mansouri, Babak Sayad, Keyghobad Ghadiri, Elham Torkashvand, Mansour Rezaei, Farid Najafi, Mohsen Azizi
BACKGROUND: Neurological complications are a problematic factor in acute bacterial meningitis; hence, its prevention is the key to ensure the success of meningitis treatment. Glycerol and dexamethasone are both applied in this regard. Oral glycerol is an appropriate alternative instead of intravenous dexamethasone because it does not have problems related to intravenous injection, the high cost, and drug complications. The main objective of this study was to compare the efficacy of adjuvant dexamethasone versus glycerol in order to improve the clinical outcome of bacterial meningitis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27899104/the-magnitude-of-nephron-number-reduction-mediates-intrauterine-growth-restriction-induced-long-term-chronic-renal-disease-in-the-rat-a-comparative-study-in-two-experimental-models
#3
Farid Boubred, Laurent Daniel, Christophe Buffat, Michel Tsimaratos, Charles Oliver, Martine Lelièvre-Pégorier, Umberto Simeoni
BACKGROUND: Intrauterine growth restriction (IUGR) is a risk factor for hypertension (HT) and chronic renal disease (CRD). A reduction in the nephron number is proposed to be the underlying mechanism; however, the mechanism is debated. The aim of this study was to demonstrate that IUGR-induced HT and CRD are linked to the magnitude of nephron number reduction, independently on its cause. METHODS: Systolic blood pressure (SBP), glomerular filtration rate (GFR), proteinuria, nephron number, and glomerular sclerosis were compared between IUGR offspring prenatally exposed to a maternal low-protein diet (9% casein; LPD offspring) or maternal administration of betamethasone (from E17 to E19; BET offspring) and offspring with a normal birth weight (NBW offspring)...
November 30, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27894430/anesthesia-for-common-pediatric-emergency-surgeries
#4
REVIEW
Matthew C Mitchell, Ibrahim Farid
Anesthesiologist must be prepared on a daily basis to care for children who need emergency surgery. An appropriate perioperative plan must be formulated and executed to ensure successful management of the child. This article outlines how to prepare and effectively manage common pediatric emergency surgeries.
February 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/27891355/the-effect-of-continuous-enteral-nutrition-on-nutrition-indices-compared-to-the-intermittent-and-combination-enteral-nutrition-in-traumatic-brain-injury-patients
#5
Sakine Mazaherpur, Alireza Khatony, Alireza Abdi, Yahia Pasdar, Farid Najafi
INTRODUCTION: Nutrition support is one of the most common care, which is undertaken for patients who suffered from Traumatic Brain Injury (TBI) and are admitted in intensive care units. Literature indicates some controversies regarding the appropriate method of nutrition support in these patients. AIM: This study was conducted for determining the effect of continuous enteral nutrition on nutrition indices, compared to the intermittent enteral and combination nutrition in TBI patients...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27889394/nanotechnology-based-drug-delivery-systems-for-alzheimer-s-disease-management-technical-industrial-and-clinical-challenges
#6
REVIEW
Ming Ming Wen, Noha S El-Salamouni, Wessam M El-Refaie, Heba A Hazzah, Mai M Ali, Giovanni Tosi, Ragwa M Farid, Maria J Blanco-Prieto, Nashiru Billa, Amira S Hanafy
Alzheimer's disease (AD) is a neurodegenerative disease with high prevalence in the rapidly growing elderly population in the developing world. The currently FDA approved drugs for the management of symptomatology of AD are marketed mainly as conventional oral medications. Due to their gastrointestinal side effects and lack of brain targeting, these drugs and dosage regiments hinder patient compliance and lead to treatment discontinuation. Nanotechnology-based drug delivery systems (NTDDS) administered by different routes can be considered as promising tools to improve patient compliance and achieve better therapeutic outcomes...
November 23, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27888682/affective-temperaments-as-measured-by-temps-a-among-self-poisoning-nonlethal-suicide-attempters
#7
Amir Rezaei Ardani, Farhad Farid Hosseini, Zahra Asadpour, Amir Masoud Hashemian, Bita Dadpour, Mahsa Nahidi
Suicidal behaviors are serious public health problems. The prominent association of mood disorders with suicide, along with the renaissance of the spectrum concept of psychiatric disorders in the recent decades, prioritizes the investigation of temperament variants in suicidal individuals. This study aimed to explore the relationship between affective temperaments and nonviolent suicide attempts. We administered Temperament Evaluation of the Memphis, Pisa, Paris, and San Diego Auto questionnaire (TEMPS-A) to 141 (27 males and 114 females) consecutive self-poisoning non-lethal suicide attempters at a Medical Toxicology Center and a sex and age matched group of healthy individuals (28 males, 112 females)...
November 17, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27888095/modulation-of-voltage-gated-conductances-of-retinal-horizontal-cells-by-uv-excited-tio2-nanoparticles
#8
Xenia Meshik, Min Choi, Adam Baker, R Paul Malchow, Leigha Covnot, Samuel Doan, Souvik Mukherjee, Sidra Farid, Mitra Dutta, Michael A Stroscio
This study examines the ability of optically-excited titanium dioxide nanoparticles to influence voltage-gated ion channels in retinal horizontal cells. Voltage clamp recordings were obtained in the presence and absence of TiO2 and ultraviolet laser excitation. Significant current changes were observed in response to UV light, particularly in the -40 mV to +40 mV region where voltage-gated Na(+) and K(+) channels have the highest conductance. Cells in proximity to UV-excited TiO2 exhibited a left-shift in the current-voltage relation of around 10 mV in the activation of Na(+) currents...
November 22, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27886514/sugar-based-novel-niosomal-nanocarrier-system-for-enhanced-oral-bioavailability-of-levofloxacin
#9
Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdelbary M A Elhissi, Waqas Nawaz, Farid Ahmad, Abdul Sadiq, Imdad Ali
CONTEXT: Vesicular systems have attracted great attention in drug delivery because of their amphiphilicity, biodegradability, non-toxicity and potential for increasing drug bioavailability. OBJECTIVE: A novel sugar-based double-tailed surfactant containing renewable block was synthesized for preparing niosomal vesicles that could be exploited for Levofloxacin encapsulation, aiming to increase its oral bioavailability. MATERIALS AND METHODS: The surfactant was characterized by (1)H NMR, mass spectroscopy and Fourier transform infrared spectroscopy (FT-IR)...
November 2016: Drug Delivery
https://www.readbyqxmd.com/read/27882205/sleep-disorders-in-methadone-maintenance-treatment-volunteers-and-opium-dependent-patients
#10
Habibolah Khazaie, Farid Najafi, Mohammad Rasoul Ghadami, Atena Azami, Marzieh Nasouri, Masoud Tahmasian, Behnam Khaledi-Paveh
BACKGROUND: The relationship between substance use and sleep is bidirectional. Substance use directly causessleep disturbances, and sleep problems are a critical factor in substance-use relapse. METHODS: This study evaluated sleep disorders in 65 methadone maintenance treatment (MMT) patients, and61 opium-dependent patients who did not receive any treatment between September 2011 and July 2012 inKermanshah, Iran. Both groups filled out the Pittsburgh Sleep Quality Index (PSQI) and Global SleepAssessment Questionnaire (GSAQ)...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27876940/echinococcus-granulosus-in-humans-associated-with-disease-incidence-in-domestic-animals-in-kermanshah-west-of-iran
#11
Abdolali Chalechale, Mohammad Hashemnia, Farid Rezaei, Maryam Sayadpour
Hydatidosis is one of the important zoonotic diseases that cause considerable economic losses and public health problems worldwide. This study was conducted to determine the prevalence Echinococcus granulosus in people and slaughtered animals in Kermanshah province, west of Iran. Hospitals data and meat-inspection records in Kermanshah abattoir were used in this study. A total number of 32,130 slaughtered livestock (7000 cattle, 19,950 sheep and 5180 goats) was inspected in the 3-year period and overall 2043 (6...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27874238/li-ion-synaptic-transistor-for-low-power-analog-computing
#12
Elliot J Fuller, Farid El Gabaly, François Léonard, Sapan Agarwal, Steven J Plimpton, Robin B Jacobs-Gedrim, Conrad D James, Matthew J Marinella, A Alec Talin
Nonvolatile redox transistors (NVRTs) based upon Li-ion battery materials are demonstrated as memory elements for neuromorphic computer architectures with multi-level analog states, "write" linearity, low-voltage switching and low power dissipation. Simulations of backpropagation using the device properties reaches ideal classification accuracy. Physics-based simulations predict energy costs per "write" operation of <10 aJ when scaled to 200 × 200 nm.
November 22, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27872690/the-effects-of-kainic-acid-induced-seizure-on-gene-expression-of-brain-neurotransmitter-receptors-in-mice-using-rt-2-pcr-array
#13
Taghi Naserpour Farivar, Marjan Nassiri-Asl, Pouran Johari, Reza Najafipour, Farid Hajiali
INTRODUCTION: Kainic acid (KA) induces neuropathological changes in specific regions of the mouse hippocampus comparable to changes seen in patients with chronic temporal lobe epilepsy (TLE). According to different studies, the expression of a number of genes are altered in the adult rat hippocampus after status epilepticus (SE) induced by KA. This study aimed to quantitatively evaluate changes in the gene expression of brain neurotransmitter receptors one week after administration of kainic acid in the mouse hippocampus...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27872289/fibrous-nonlinear-elasticity-enables-positive-mechanical-feedback-between-cells-and-ecms
#14
Matthew S Hall, Farid Alisafaei, Ehsan Ban, Xinzeng Feng, Chung-Yuen Hui, Vivek B Shenoy, Mingming Wu
In native states, animal cells of many types are supported by a fibrous network that forms the main structural component of the ECM. Mechanical interactions between cells and the 3D ECM critically regulate cell function, including growth and migration. However, the physical mechanism that governs the cell interaction with fibrous 3D ECM is still not known. In this article, we present single-cell traction force measurements using breast tumor cells embedded within 3D collagen matrices. We recreate the breast tumor mechanical environment by controlling the microstructure and density of type I collagen matrices...
November 21, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27872185/the-major-replicative-histone-chaperone-caf-1-suppresses-the-activity-of-the-dna-mismatch-repair-system-in-the-cytotoxic-response-to-a-dna-methylating-agent
#15
Lyudmila Y Kadyrova, Basanta K Dahal, Farid A Kadyrov
The DNA mismatch repair (MMR) system corrects DNA mismatches in the genome. It is also required for the cytotoxic response of O(6)-methylguanine-DNA methyltransferase (MGMT)-deficient mammalian cells and yeast mgt1Δ rad52Δ cells to treatment with Sn1-type methylating agents, which produce cytotoxic O(6)-methylguanine (O(6)-mG) DNA lesions. Specifically, processing of irreparable O(6)-mG-containing mispairs by the MMR system causes DNA degradation, triggering cell death; this process forms the basis of treatments of MGMT-deficient cancers with Sn1-type methylating drugs...
November 21, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27869363/is-the-memorial-sloan-kettering-cancer-centre-mskcc-sarcoma-nomogram-useful-in-an-asian-population
#16
Deanna Wan Jie Ng, Grace Hwei Ching Tan, Claramae Shulyn Chia, Cindy Xindi Lim, Soo Khee Chee, Richard Hong Hui Quek, Mohamad Farid, Melissa Ching Ching Teo
AIM: A nomogram for prediction of 12-year sarcoma-specific survival has been developed based on patients with soft tissue sarcomas treated in Memorial Sloan Kettering Cancer Centre (MSKCC). We aim to evaluate the predictive accuracy of the MSKCC sarcoma nomogram in a cohort of patients treated at an Asian institution. This has not been validated in an Asian population and thus its universal applicability remains unproven. MATERIALS AND METHODS: Between 1990 and 2013, 840 adult patients underwent treatment for primary soft tissue sarcoma (STS) at the National Cancer Centre Singapore...
November 21, 2016: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27867068/evaluation-of-arch-forms-depending-on-the-angle-classification
#17
Farid Bourzgui, Asmaa Khribchi, Zineb Rachdy, Sami Housbane, Mohamed Bennani Othmani
: It is generally accepted that each individual has his or her own dental arch form. However, during orthodontic treatment, industrially preshaped archwires are widely used. The resulting use of the same arch form for all malocclusions may compromise occlusal stability after orthodontic treatment. AIM: To determine the average dental arch form of a non-consulting Moroccan population depending on the Angle classification, after digitization of plaster models of the dental arches...
November 17, 2016: International Orthodontics
https://www.readbyqxmd.com/read/27867066/%C3%A3-valuation-des-formes-d%C3%A2-arcades-selon-la-classification-d%C3%A2-angle
#18
Farid Bourzgui, Asmaa Khribchi, Zineb Rachdy, Sami Housbane, Mohamed Bennani Othmani
No abstract text is available yet for this article.
November 17, 2016: International Orthodontics
https://www.readbyqxmd.com/read/27865949/lost-in-translation-the-potential-psychobiotic-lactobacillus-rhamnosus-jb-1-fails-to-modulate-stress-or-cognitive-performance-in-healthy-male-subjects
#19
John R Kelly, Andrew P Allen, Andriy Temko, William Hutch, Paul J Kennedy, Niloufar Farid, Eileen Murphy, Geraldine Boylan, John Bienenstock, John F Cryan, Gerard Clarke, Timothy G Dinan
BACKGROUND: Preclinical studies have identified certain probiotics as psychobiotics - live microorganisms with a potential mental health benefit. Lactobacillus rhamnosus (JB-1) has been shown to reduce stress-related behaviour, corticosterone release and alter central expression of GABA receptors in an anxious mouse strain. However, it is unclear if this single putative psychobiotic strain has psychotropic activity in humans. Consequently, we aimed to examine if these promising preclinical findings could be translated to healthy human volunteers...
November 16, 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/27864623/simplified-hcc-art-score-for-highly-sensitive-detection-of-small-sized-and-early-stage-hepatocellular-carcinoma-in-the-widely-used-okuda-clip-and-bclc-staging-systems
#20
Abdelfattah M Attallah, Mohamed M Omran, Ahmed A Attallah, Mohamed A Abdelrazek, Khaled Farid, Ibrahim El-Dosoky
BACKGROUND: Small-sized HCC can be effectively cured by surgery with good clinical outcomes. A highly sensitive HCC α-fetoprotein routine test (HCC-ART) for HCC diagnosis as well as a simplied form of the HCC-ART were reported in the British Journal of Cancer. Here, we verified and studied the applicability of the HCC-ART to the detection of early-stage HCC. METHODS: 341 cirrhotic patients and 318 HCC patients were included in this study. For each, the HCC-ART score was calculated, and then the sensitivity, specificity, and results of an ROC curve analysis were compared between the HCC-ART and AFP when these biomarkers were used to detect small-sized HCC...
November 18, 2016: International Journal of Clinical Oncology
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