Kerstin Rahn, Ali T Abdallah, Lin Gan, Shelley Herbrich, Roland Sonntag, Oscar Benitez, Prerna Malaney, Xiaorui Zhang, Ashely G Rodriguez, Jared Brottem, Gernot Marx, Tim H Brümmendorf, Dirk H Ostareck, Antje Ostareck-Lederer, Martina Crysandt, Sean M Post, Isabel S Naarmann-de Vries
Deletions on the long arm of chromosome 9 (del(9q)) are recurrent abnormalities in about 2 % of acute myeloid leukemia cases, which usually involve HNRNPK and are frequently associated with other known aberrations. Based on an Hnrnpk haploinsufficient mouse model, a recent study demonstrated a function of hnRNP K in pathogenesis of myeloid malignancies via the regulation of cellular proliferation and myeloid differentiation programs. Here, we provide evidence that reduced hnRNP K expression results in the dysregulated expression of C/EBPα and additional transcription factors...
November 24, 2023: Biochimica et Biophysica Acta. Gene Regulatory Mechanisms