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https://www.readbyqxmd.com/read/28913777/diabetes-and-the-small-intestine
#1
REVIEW
Jonathan Gotfried, Stephen Priest, Ron Schey
Diabetes mellitus (DM) and its associated complications are becoming increasingly prevalent. Gastrointestinal symptoms associated with diabetes is known as diabetic enteropathy (DE) and may manifest as either diarrhea, fecal incontinence, constipation, dyspepsia, nausea, and vomiting or a combination of symptoms. The long-held belief that vagal autonomic neuropathy is the primary cause of DE has recently been challenged by newer theories of disease development. Specifically, hyperglycemia and the resulting oxidative stress on neural networks, including the nitrergic neurons and interstitial cells of Cajal (ICC), are now believed to play a central role in the development of DE...
September 15, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28879488/diabetes-and-the-stomach
#2
REVIEW
Allen A Lee, William L Hasler
Longstanding diabetes mellitus (both type 1 and type 2) can impair gastric motor function and cause significant upper gastrointestinal symptoms which significantly degrade quality of life, cause nutritional deficits, and degrade healthcare resource use. The most commonly considered gut complication of diabetes, diabetic gastroparesis, is a syndrome of delayed gastric emptying in the absence of mechanical obstruction which leads to symptoms of nausea, vomiting, postprandial fullness, early satiation, bloating, and upper abdominal pain...
September 6, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28872760/relating-gastric-scintigraphy-and-symptoms-to-motility-capsule-transit-and-pressure-findings-in-suspected-gastroparesis
#3
W L Hasler, K P May, L A Wilson, M Van Natta, H P Parkman, P J Pasricha, K L Koch, T L Abell, R W McCallum, L A Nguyen, W J Snape, I Sarosiek, J O Clarke, G Farrugia, J Calles-Escandon, M Grover, J Tonascia, L A Lee, L Miriel, F A Hamilton
BACKGROUND: Wireless motility capsule (WMC) findings are incompletely defined in suspected gastroparesis. We aimed to characterize regional WMC transit and contractility in relation to scintigraphy, etiology, and symptoms in patients undergoing gastric emptying testing. METHODS: A total of 209 patients with gastroparesis symptoms at NIDDK Gastroparesis Consortium centers underwent gastric scintigraphy and WMCs on separate days to measure regional transit and contractility...
September 5, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28871499/a-prospective-evaluation-of-ileocecal-valve-dysfunction-and-intestinal-motility-derangements-in-small-intestinal-bacterial-overgrowth
#4
Bani Chander Roland, Gerard E Mullin, Monica Passi, Xi Zheng, Ahmed Salem, Robert Yolken, Pankaj Jay Pasricha
BACKGROUND: Small intestinal bacterial overgrowth (SIBO) is an increasingly recognized clinical syndrome; however, its etiophathogenesis is poorly understood. We hypothesized that loss of gastric acid, a delayed intestinal transit, and ileocecal valve dysfunction may contribute to the genesis of this syndrome. AIMS: Our primary aim was to assess these parameters using wireless motility capsule (WMC) testing and to correlate them with the presence or absence of SIBO...
September 4, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28621589/effect-of-hospitalization-on-gastrointestinal-motility-and-ph-in-dogs
#5
Kanawee Warrit, Pedro Boscan, Leah E Ferguson, Allison M Bradley, Kristy L Dowers, David C Twedt
OBJECTIVE To determine the effect of hospitalization on gastrointestinal motility and pH in healthy dogs. DESIGN Experimental study. ANIMALS 12 healthy adult dogs. PROCEDURES A wireless motility capsule (WMC) that measured pressure, transit time, and pH within the gastrointestinal tract was administered orally to dogs in 2 phases. In the first phase, dogs received the WMC at the hospital and then returned to their home to follow their daily routine. In the second phase, dogs were hospitalized, housed individually, had abdominal radiography performed daily, and were leash exercised 4 to 6 times/d until the WMC passed in the feces...
July 1, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28571122/detecting-the-non-physiological-surgically-tailored-ileocolic-anastomosis-using-the-wireless-motility-capsule-a-pre-and-post-operative-prospective-within-subject-trial
#6
Yngve Thorsen, Bojan V Stimec, Jens M Nesgaard, Dejan Ignjatovic
Background/Aims: Wireless motility capsule (WMC) detects the ileocolic junction (ICJ) in most non-operated patients. We find no data concerning this examination in patients where the ileocolic valve is replaced by a per definition incompetent, surgically created ICJ. We wanted to see if WMC could detect the ICJ after a right colectomy and assess the competency. Methods: Prospective cohort study using a within-subject design to eliminate subject-subject variability...
June 1, 2017: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/28524600/validation-of-smartpill-%C3%A2-wireless-motility-capsule-for-gastrointestinal-transit-time-intra-subject-variability-software-accuracy-and-comparison-with-video-capsule-endoscopy
#7
H O Diaz Tartera, D-L Webb, A Kh Al-Saffar, M A Halim, G Lindberg, P Sangfelt, P M Hellström
BACKGROUND: There is interest in ultimately combining endoscopy and motility assessments. Gastric emptying (GET), small bowel (SBTT), colon (CTT) and whole gut transit (WGTT) times are conveniently obtained by SmartPill(®) wireless motility capsule (WMC) that records luminal pH, temperature and pressure. Reproducibility within same subjects and accuracy of software derived times (MotiliGI(®) ) were investigated for diagnostic application. GET and SBTT were separately measured using video capsule endoscopy (VCE)...
May 19, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28444862/role-of-wireless-motility-capsule-in-the-assessment-and-management-of-gastrointestinal-dysmotility-in-patients-with-diabetes-mellitus
#8
C Rouphael, Z Arora, P N Thota, R Lopez, J Santisi, C Funk, M Cline
BACKGROUND: Gastrointestinal (GI) dysmotility is common in diabetic patients. Wireless Motility Capsule (WMC) provides the transit profile of the entire GI tract in a single study. Factors affecting GI dysmotility and utility of WMC study are not clearly established in diabetic patients. Our aims were to study the pattern of GI dysmotility using WMC and evaluate the effect of glycemic control and presence of diabetic microvascular complications on motility impairment in diabetic patients...
September 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28321329/utility-of-the-wireless-motility-capsule-and-lactulose-breath-testing-in-the-evaluation-of-patients-with-parkinson-s-disease-who-present-with-functional-gastrointestinal-symptoms
#9
Andrew Su, Rita Gandhy, Carrolee Barlow, George Triadafilopoulos
BACKGROUND: The aetiology and origin of gastrointestinal symptoms in Parkinson's disease (PD) remains poorly understood. Gastroparesis, small bowel transit delay and bacterial overgrowth may, individually or collectively, play a role. AIMS: In patients with PD and functional gastrointestinal symptoms, we aimed to determine the utility of the wireless motility capsule and lactulose breath tests in further defining their symptoms' aetiology. METHODS: In this retrospective cohort study, consecutive patients with PD and functional gastrointestinal symptoms underwent clinical assessment, as well as wireless motility capsule and lactulose breath testing using standard protocols...
2017: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/28300821/impact-of-cftr-modulation-on-intestinal-ph-motility-and-clinical-outcomes-in-patients-with-cystic-fibrosis-and-the-g551d-mutation
#10
Daniel Gelfond, Sonya Heltshe, Changxing Ma, Steven M Rowe, Carla Frederick, Ahmet Uluer, Leonard Sicilian, Michael Konstan, Elizabeth Tullis, R N Christine Roach, Katherine Griffin, Elizabeth Joseloff, Drucy Borowitz
OBJECTIVES: A defect in bicarbonate secretion contributes to the pathophysiology of gastrointestinal complications in patients with cystic fibrosis (CF). We measured gastrointestinal pH, clinical outcomes, and intestinal transit profiles in patients with the G551D mutation before and after treatment with ivacaftor, a CF transmembrane regulator channel (CFTR) potentiator. METHODS: Observational studies of ivacaftor effectiveness were conducted in the United States and Canada...
March 16, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28105520/type-1-diabetic-patients-with-peripheral-neuropathy-have-pan-enteric-prolongation-of-gastrointestinal-transit-times-and-an-altered-caecal-ph-profile
#11
RANDOMIZED CONTROLLED TRIAL
Adam D Farmer, Anne Grave Pedersen, Birgitte Brock, Poul Erik Jakobsen, Jesper Karmisholt, Sahar D Mohammed, S Mark Scott, Asbjørn Mohr Drewes, Christina Brock
AIMS/HYPOTHESIS: We hypothesised that type 1 diabetic patients with established diabetic sensorimotor polyneuropathy (DSPN) would have segmental and/or pan-enteric dysmotility in comparison to healthy age-matched controls. We aimed to investigate the co-relationships between gastrointestinal function, degree of DSPN and clinical symptoms. METHODS: An observational comparison was made between 48 patients with DSPN (39 men, mean age 50 years, range 29-71 years), representing the baseline data of an ongoing clinical trial (representing a secondary analysis of baseline data collected from an ongoing double-blind randomised controlled trial investigating the neuroprotective effects of liraglutide) and 41 healthy participants (16 men, mean age 49 years, range 30-78) who underwent a standardised wireless motility capsule test to assess gastrointestinal transit...
April 2017: Diabetologia
https://www.readbyqxmd.com/read/27922028/a-randomized-double-blind-placebo-controlled-trial-to-examine-the-effectiveness-of-lubiprostone-on-constipation-symptoms-and-colon-transit-time-in-diabetic-patients
#12
RANDOMIZED CONTROLLED TRIAL
Jennifer Christie, Sagar Shroff, Nikrad Shahnavaz, Latoya A Carter, Melanie S Harrison, Karan A Dietz-Lindo, John Hanfelt, Shanthi Srinivasan
OBJECTIVES: Constipation is the most common GI symptom in patients with diabetes mellitus (DM). Importantly, patients with constipation have lower health-related quality of life than those without constipation. Effective therapies for constipation are limited and there is a paucity of data evaluating the treatment of constipation in diabetics. METHODS: Diabetic patients with chronic idiopathic constipation (CIC) as defined by Rome III criteria were recruited from outpatient clinics at a tertiary-care center and a Veterans Administration Hospital...
February 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27843572/utility-of-high-resolution-anorectal-manometry-and-wireless-motility-capsule-in-the-evaluation-of-patients-with-parkinson-s-disease-and-chronic-constipation
#13
Andrew Su, Rita Gandhy, Carrolee Barlow, George Triadafilopoulos
BACKGROUND: The aetiology of constipation in Parkinson's disease remains poorly understood. Defaecatory dyssynergia, anal sphincter spasticity and slow transit constipation may, individually or collectively, play a role. AIMS: In this retrospective cohort analysis of patients with Parkinson's disease and chronic constipation, we determined the utility of high-resolution anorectal manometry, balloon expulsion and wireless motility capsule testing in defining the underlying aetiology for constipation...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27810622/generic-feature-learning-for-wireless-capsule-endoscopy-analysis
#14
Santi Seguí, Michal Drozdzal, Guillem Pascual, Petia Radeva, Carolina Malagelada, Fernando Azpiroz, Jordi Vitrià
The interpretation and analysis of wireless capsule endoscopy (WCE) recordings is a complex task which requires sophisticated computer aided decision (CAD) systems to help physicians with video screening and, finally, with the diagnosis. Most CAD systems used in capsule endoscopy share a common system design, but use very different image and video representations. As a result, each time a new clinical application of WCE appears, a new CAD system has to be designed from the scratch. This makes the design of new CAD systems very time consuming...
December 1, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27650225/lubiprostone-accelerates-intestinal-transit-and-alleviates-small-intestinal-bacterial-overgrowth-in-patients-with-chronic-constipation
#15
Irene Sarosiek, Mohammad Bashashati, Alicia Alvarez, Mark Hall, Nagasri Shankar, Yvette Gomez, Richard W McCallum, Jerzy Sarosiek
BACKGROUND: Lubiprostone is an effective treatment for chronic constipation (CC). The mechanism of action of lubiprostone is through increasing fluid secretion and lubrication of the intestinal lumen. The effects of lubiprostone on gastrointestinal transit and small intestinal bacterial overgrowth (SIBO) have not been adequately explored. The current study was designed to investigate whether lubiprostone (1) alters gastrointestinal transit and (2) affects SIBO in patients with constipation...
September 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27648298/utility-of-wireless-motility-capsule-and-lactulose-breath-testing-in-the-evaluation-of-patients-with-chronic-functional-bloating
#16
George Triadafilopoulos
BACKGROUND: The precise aetiology of chronic bloating remains poorly understood and underlying gastroparesis, small bowel bacterial overgrowth and colonic inertia may, individually or collectively, play a role. AIMS: In this retrospective cohort analysis of symptomatic patients with chronic persistent bloating, we determined the clinical utility of wireless motility capsule and lactulose breath test in further defining the underlying aetiology for functional bloating...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27092333/morpho-functional-evaluation-of-small-bowel-using-wireless-motility-capsule-and-video-capsule-endoscopy-in-patients-with-known-or-suspected-crohn-s-disease-pilot-study
#17
Diana Yung, Sarah Douglas, Anthony R Hobson, Andry Giannakou, John N Plevris, Anastasios Koulaouzidis
BACKGROUND AND STUDY AIMS: SmartPill(®) (Given Imaging Corp.,Yoqneam,Israel) is an ingestible, non-imaging capsule that records physiological data including contractions and pH throughout the gastrointestinal tract. There are scarce data looking at SmartPill(®) assessment of patients with known/suspected small-bowel Crohn's Disease (CD). This pilot study aims to investigate feasibility and safety of SmartPill(®) to assess gut motility in this group.  PATIENTS AND METHODS: Over 1 year, patients with known/suspected CD, referred for small-bowel capsule endoscopy (SBCE), were invited to participate and 12 were recruited (7 female, 5 male, mean age 44...
April 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27070390/-not-available
#18
REVIEW
Hetzel Diaz, Ulrika Sjöström, Greger Lindberg, Per M Hellström
The wireless motility-recording capsule, "SmartPill", is an ingested one-time use electronic capsule that measures gastrointestinal luminal pressure, pH and temperature along the whole gastrointestinal tract. The pH profile and the pressure patterns define the time at which the capsule moves from the stomach to the duodenum and from the ileum to the caecum, whereas changes in temperature define the times of ingestion and expulsion. The recordings from the wireless motility capsule are sent from a radio transmitter in the capsule to a receiver carried around the waist...
April 11, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27033126/diagnosis-and-management-of-chronic-constipation-in-adults
#19
REVIEW
Satish S C Rao, Kulthep Rattanakovit, Tanisa Patcharatrakul
Constipation is a heterogeneous, polysymptomatic, multifactorial disease. Acute or transient constipation can be due to changes in diet, travel or stress, and secondary constipation can result from drug treatment, neurological or metabolic conditions or, rarely, colon cancer. A diagnosis of primary chronic constipation is made after exclusion of secondary causes of constipation and encompasses several overlapping subtypes. Slow-transit constipation is characterized by prolonged colonic transit in the absence of pelvic floor dysfunction...
May 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26908282/the-wireless-motility-capsule-a-one-stop-shop-for-the-evaluation-of-gi-motility-disorders
#20
REVIEW
Richard J Saad
The wireless motility and pH capsule (WMC) provides an office-based test to simultaneously assess both regional and whole gut transit. Ingestion of this non-digestible capsule capable of measuring temperature, pH, and the pressure of its immediate surroundings allows for the measurement of gastric, small bowel, and colonic transit times in an ambulatory setting. Approved by the US Food and Drug Administration for the evaluation of suspected conditions of delayed gastric emptying and the evaluation of colonic transit in chronic idiopathic constipation, WMC should be considered in suspected gastrointestinal motility disorders as it provides a single study capable of simultaneously assessing for regional, multiregional, or generalized motility disorders...
March 2016: Current Gastroenterology Reports
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