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Rhinorrhea

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https://www.readbyqxmd.com/read/29223274/a-woman-in-her-60s-with-lung-adenocarcinoma-presents-with-copious-watery-sputum-and-respiratory-failure
#1
Nicole L Roeder, Jeffrey D Marshall, Clemente J Britto
A woman in her 60s presented with 1 month of progressive dyspnea, watery rhinorrhea, and paroxysmal cough productive of clear, watery sputum. She was diagnosed with epidermal growth factor receptor (EGFR) mutation-positive lung adenocarcinoma at another institution 1 week prior to presentation and 3 weeks after the onset of symptoms. She was a never-smoker. She denied fevers and had completed a course of antibiotics for presumed pneumonia, without clinical improvement. She presented to the hospital due to increasing severity of her shortness of breath...
December 2017: Chest
https://www.readbyqxmd.com/read/29209151/endoscopic-repair-of-lateral-sphenoid-encephaloceles-a-case-series
#2
Mitchell R Gore
Background: Lateral sphenoid encephaloceles present a surgical challenge. These encephaloceles may be difficult to access given their lateral location and proximity to the neural and vascular structures of the sphenoid floor, pterygopalatine fossa, and lateral and superior sphenoid walls. Additionally, many patients have idiopathic intracranial hypertension, increasing the risk of recurrence. When untreated or undiscovered, these encephaloceles increase the risk of meningitis. Methods: All consecutive endoscopic repairs of lateral sphenoid encephaloceles by a single surgeon from 2012 to 2017 were analyzed for method of repair, complications, and recurrence rate...
2017: BMC Ear, Nose, and Throat Disorders
https://www.readbyqxmd.com/read/29195025/lack-of-additional-effects-of-long-term-low-dose-clarithromycin-combined-treatment-compared-with-topical-steroids-alone-for-chronic-rhinosinusitis-in-china-a-randomized-controlled-trial
#3
Jie Deng, Fenghong Chen, YinYan Lai, Qing Luo, Rui Xu, Chunquan Ou, Qingling Fu, Jianbo Shi
BACKGROUND: In China, clarithromycin is considered an effective treatment option for chronic rhinosinusitis (CRS) due to its unique immunopathologic characteristics. Our study's aim was to determine whether a topical steroid and clarithromycin combination is better than a single topical steroid for Chinese patients with CRS. METHODS: Patients with CRS with/without nasal polyps were included in this study and randomly assigned to a clarithromycin plus budesonide aqua nasal spray group (CLM + BUD, clarithromycin 0...
November 30, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29171299/whole-body-exposure-of-rats-to-sulfur-mustard-vapor
#4
Shlomit Dachir, Ishai Rabinovitz, Guy Yaacov, Hila Gutman, Liat Cohen, Vered Horwitz, Maayan Cohen, Tamar Kadar
Sulfur mustard (SM) is an incapacitating chemical warfare agent used in numerous conflicts around the world and it is still a major threat for both, army troops and civilians. To evaluate its multiple targets effects in experimental setup, a model of whole body exposure (WBE) to SM vapor was established in rats and its simultaneous effects on lungs and eyes as well as on general wellbeing were examined. Rats were exposed to SM vapor. Evaluation (up to 10 weeks post-exposure) included body weight, general observation, blood counts and histological analysis...
November 24, 2017: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29152752/nasoseptal-flap-closure-of-the-eustachian-tube-for-recalcitrant-cerebrospinal-fluid-rhinorrhea
#5
Vishal S Patel, Garret W Choby, Andrew Thamboo, Nikolas H Blevins, Peter H Hwang
No abstract text is available yet for this article.
November 20, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29151333/isolated-sphenoid-sinus-pathologies-a-series-of-40-cases
#6
Fakih Cihat Eravcı, Alper Ceylan, Mehmet Göcek, Fikret İlerı, Süleyman Sabri Uslu, Metin Yılmaz, Yusuf Kızıl
Background/aim: Isolated sphenoid sinus-derived lesions are rare and generally present with unclear symptoms. We are sharing our experience to be mindful of such lesions in differential diagnosis and to help accomplish successful treatment while avoiding revisions and complications.Materials and methods: Data from patients who underwent isolated sphenoid sinus surgeries (ISSs) were retrospectively extracted from the period of January 2005 to August 2015. Demographic data, chief complaints and presenting symptoms, imaging findings, surgical management, and results were evaluated...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29144269/50-years-ago-in-the-journal-of-pediatrics-diagnosis-of-cerebrospinal-fluid-rhinorrhea-lack-of-specificity-of-the-glucose-oxidase-test-tape
#7
Susy Jeng
No abstract text is available yet for this article.
November 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29122086/endonasal-endoscopic-management-of-frontal-sinus-cerebrospinal-fluid-leak
#8
Javaneh Jahanshahi, Mehdi Zeinalizadeh, Hasan Reza Mohammadi, Seyed Mousa Sadrehosseini
BACKGROUND: A frontal sinus leak is uncommon and is seen in ∼15% of cases of patients with cerebrospinal fluid (CSF) rhinorrhea. Now, endonasal endoscopic techniques have been reported to reconstruct skull base defects in the frontal sinus with a favorable outcome. OBJECTIVE: To review our experience in the repair of frontal sinus CSF leaks through an endonasal endoscopic approach. METHODS: Twenty-four patients with a frontal sinus leak who underwent endonasal endoscopic repair entered the study...
November 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/29095707/long-term-management-and-outcomes-after-repair-of-cerebrospinal-fluid-rhinorrhea-related-to-idiopathic-intracranial-hypertension
#9
Theodore A Schuman, Brent A Senior
PURPOSE OF REVIEW: To identify long-term management strategies and outcomes for the treatment of spontaneous cerebrospinal fluid (CSF) rhinorrhea related to idiopathic intracranial hypertension (IIH). RECENT FINDINGS: Adjuvant treatments following surgical repair of spontaneous CSF leaks are aimed at normalizing intracranial pressure (ICP) to minimize the risk of recurrence. IIH is closely linked to obesity, and growing evidence suggests that weight loss, both through conservative and surgical approaches, is effective at addressing the root cause of this disorder...
October 31, 2017: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/29094066/surgical-repair-of-spontaneous-cerebrospinal-fluid-csf-leaks-a-systematic-review
#10
REVIEW
Brian C Lobo, Maraya M Baumanis, Rick F Nelson
Objectives: To review the safety and efficacy of surgical management for spontaneous cerebrospinal fluid (CSF) leaks of the anterior and lateral skull base. Data Sources: A systematic review of English articles using MEDLINE. Review Methods: Search terms included spontaneous, CSF, cerebrospinal fluid, endoscopic, middle fossa, transmastoid, leak, rhinorrhea. Independent extraction of articles by 3 authors. Results: Patients with spontaneous CSF leaks are often obese (average BMI of 38 kg/m2) and female (72%)...
October 2017: Laryngoscope Investigative Otolaryngology
https://www.readbyqxmd.com/read/29075960/a-case-of-fungus-ball-type-maxillary-sinusitis-due-to-penicillium-roqueforti
#11
T Radulesco, A Varoquaux, S Ranque, P Dessi, J Michel, C Cassagne
The Penicillium genera, encompassing about 225 different species of fungi, are naturally present in the environment. These genera are poorly linked to human disease, except for Penicillium marneffei causing septicemia in immunocompromised hosts. Thus, Penicillium species recovered from respiratory tract samples are often considered as inhaled contaminants in the clinical laboratory. However, we report here a case of fungal maxillary sinusitis due to Penicillium roqueforti diagnosed in a 40-year-old female, a teacher, complaining of moderate pain for months in the maxillary sinus and chronic posterior rhinorrhea...
October 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/29070275/long-term-follow-up-of-a-patient-with-malignant-transformation-of-inverted-papilloma-into-sinonasal-undifferentiated-carcinoma
#12
Carolyn A Orgain, Terry Y Shibuya, Lester D Thompson, David B Keschner, Rohit Garg, Jivianne T Lee
INTRODUCTION: Inverted papillomas (IP) are benign sinonasal neoplasms, which account for 0.5-4% of all nasal tumors. IPs have been known to transform into squamous cell carcinoma in 5-15% of cases. Rarely, transformations to other malignancies have been reported. Here we report a unique case of malignant transformation of an IP into sinonasal undifferentiated carcinoma (SNUC). METHODS: A case report with a literature review; institutional review board exempted. The clinical presentation, radiographic features, surgical intervention, histopathologic analysis, treatment, and outcome of the case were examined...
October 1, 2017: Allergy & Rhinology
https://www.readbyqxmd.com/read/29055142/the-fate-of-the-bone-graft-in-cerebrospinal-fluid-rhinorrhea-endoscopic-repair-for-idiopathic-intracranial-hypertension-a-retrospective-case-series-analysis
#13
A D Workman, R M Carey, A K Parasher, E C Kuan, J Godovchik, J T Glicksman, D W Kennedy, J N Palmer, N D Adappa
INTRODUCTION: Idiopathic intracranial hypertension (IIH) is a common cause of spontaneous cerebrospinal fluid (CSF) leaks necessitating surgical intervention, and grafting of septal, mastoid, or turbinate bone over the defect is increasingly performed to strengthen the repair of the primary defect. However, the postoperative fate of these grafted bone fragments is largely unknown. METHODOLOGY: We performed a retrospective study of patients at the University of Pennsylvania undergoing repair of spontaneous CSF leaks secondary to IIH...
October 21, 2017: Rhinology
https://www.readbyqxmd.com/read/29053231/effects-of-common-cold-and-concomitant-administration-of-nasal-decongestant-on-the-pharmacokinetics-and-pharmacodynamics-of-nasal-glucagon-in-otherwise-healthy-participants-a-randomized-clinical-trial
#14
Cristina B Guzman, Helene Dulude, Claude Piché, Marianne Rufiange, Aziz A Sadoune, Emmanouil Rampakakis, Dolores Carballo, Myriam Triest, Michelle Xiaotian Zhang, Shuyu Zhang, Maryam Tafreshi, Eric Sicard
AIMS: Nasal glucagon (NG) is a nasally-administered glucagon powder, absorbed through the nasal mucosa, designed for treatment of severe hypoglycaemia. This study evaluated safety, pharmacokinetics (PK), and pharmacodynamics (PD) of NG in otherwise healthy participants with common colds and after recovery from cold symptoms, with and without concomitant nasal decongestant. MATERIALS AND METHODS: This was a single-centre, open-label study. Cohort 1 participants (N=18) received two NG doses: one while experiencing nasal congestion and another after recovery from cold symptoms...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29050748/pediatric-kikuchi-fujimoto-disease-a-clinicopathologic-study-and-the-therapeutic-effects-of-hydroxychloroquine
#15
Yung-Chih Lin, Hsiu-Hui Huang, Bao-Ren Nong, Po-Yen Liu, Ying-Yao Chen, Yung-Feng Huang, Yee-Hsuan Chiou, Herng-Sheng Lee
BACKGROUND: To investigate the clinical features of Kikuchi-Fujimoto disease (KFD) in children, and place an emphasis on the therapeutic effects of hydroxychloroquine as monotherapy. METHODS: We retrospectively reviewed the medical records of all children diagnosed with KFD during the period January 1992 to September 2016 at a tertiary medical center in Taiwan. RESULTS: 40 patients were histopathologically confirmed as KFD, and the mean age of the patients was 13...
September 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29033449/symptomatology-patterns-in-children-with-allergic-rhinitis
#16
Michael Katotomichelakis, Theodoros Iliou, Ioannis Karvelis, Evangelos Giotakis, Gerasimos Daniilides, Eleni Erkotidou, Christos Lazaridis, George K Anastassopoulos
BACKGROUND Although allergic rhinitis (AR) is recognized as a growing global health disease with considerable importance for patients' lives, especially among children and adolescents, there is a lack of population studies concerning symptomatology patterns of the disease. The present study aimed to explore symptoms prevalence among school-aged children, to detect any correlation between allergen sensitivities with symptomatology patterns, and, finally, to evaluate the association of the sensitivity grade score with symptoms severity or seasonality...
October 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28978177/binostril-endoscopic-transsphenoidal-neurosurgery-for-pituitary-adenomas-experience-with-42-patients
#17
Guan Sun, Ying Cao, Nan Jiang, Dekang Nie, Zhengqiang Wan, Min Li, Chiyuan Ma, Jun Guo
Here we review the technical aspects of our experience with the neuroendoscopic bilateral nostril (binostril) transsphenoidal approach for pituitary adenomas. A total of 42 patients were treated in our hospital from September 2013 to December 2015. Total tumor resection was completed in 31 cases, nearly full resection was achieved in 9 cases, and partial resection was achieved in 2 cases. In most cases clinical symptoms were relieved after surgery. These included 18/22 cases with visual field and vision disorders; 19/25 cases with headaches; 11/15 cases where high baseline PRL returned to normal levels; 6/7 cases where elevated blood GH returned to normal levels; and 2/3 cases where elevated blood ACTH returned to normal levels after surgery...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28975651/risk-factors-of-respiratory-syncytial-virus-infection-among-pediatric-influenza-like-illness-and-severe-acute-respiratory-infections-in-suzhou-china
#18
Yukai Huang, Jun Hua, Dan Wang, Liling Chen, Jun Zhang, Hong Zhu, Jianmei Tian, Tao Zhang, Genming Zhao
Background The characteristics and risk factors of respiratory syncytial virus (RSV) infection among children has not yet been fully understood. Objectives To address the characteristics of RSV-associated illness and risk factors of RSV infection among children under 5 years of age in Suzhou, China. Methods From April 2011 to March 2014, we conducted a prospective surveillance among children in Suzhou, China. Nasal or throat swabs were collected from outpatients with influenza-like illness (ILI) and inpatients with severe acute respiratory infections (SARI)...
October 3, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28960156/identification-and-repair-of-intraoperative-cerebrospinal-fluid-leaks-in-endonasal-transsphenoidal-pituitary-surgery-surgical-experience-in-a-series-of-1002-patients
#19
Ben A Strickland, Joshua Lucas, Brianna Harris, Edwin Kulubya, Joshua Bakhsheshian, Charles Liu, Bozena Wrobel, John D Carmichael, Martin Weiss, Gabriel Zada
OBJECTIVE Cerebrospinal fluid (CSF) rhinorrhea is among the most common complications following transsphenoidal surgery for sellar region lesions. The aim of this study was to review the authors' institutional experience in identifying, repairing, and treating CSF leaks associated with direct endonasal transsphenoidal operations. METHODS The authors performed a retrospective review of cases involving surgical treatment of pituitary adenomas and other sellar lesions at the University of Southern California between December 1995 and March 2016...
September 29, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28959875/postoperative-cerebrospinal-fluid-rhinorrhea-in-puerperal-women-following-transcranial-resection-of-tuberculum-sella-meningiomas
#20
Ben Shofty, Lior Gonen, Sarit Avraham, Avraham Abergel, Daniel Umansky, Nevo Margalit
No abstract text is available yet for this article.
September 28, 2017: Journal of Neurosurgical Sciences
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