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https://www.readbyqxmd.com/read/27890184/imaging-of-cerebrospinal-fluid-rhinorrhea-and-otorrhea
#1
REVIEW
Mahati Reddy, Kristen Baugnon
As the obesity epidemic grows in the United States, rhinorrhea and otorrhea from spontaneous cerebrospinal fluid (CSF) leaks secondary to untreated idiopathic intracranial hypertension are increasing in prevalence. CSF rhinorrhea and otorrhea should also be carefully evaluated in posttraumatic and postsurgical settings, because untreated CSF leaks often have serious consequences. The work-up, diagnosis, and characterization of a CSF leak can be complex, often requiring a multimodality approach to optimize surgical planning...
January 2017: Radiologic Clinics of North America
https://www.readbyqxmd.com/read/27885562/respiratory-syncytial-virus-and-influenza-are-the-key-viral-pathogens-in-children-2%C3%A2-years-hospitalized-with-bronchiolitis-and-pneumonia-in-islamabad-pakistan
#2
Uzma Bashir, Nadia Nisar, Yasir Arshad, Muhammad Masroor Alam, Asiya Ashraf, Hajra Sadia, Birjees Mazher Kazi, Syed Sohail Zahoor Zaidi
Pneumonia remains a leading cause of morbidity and mortality in developing countries. Comprehensive surveillance data are needed to review the prevention and control strategies. We conducted active surveillance of acute lower respiratory infections among children aged <2 years hospitalized at two hospitals of Islamabad, Pakistan. Viral etiology was determined using real-time PCR on respiratory specimens collected during March 2011-April 2012. The overall mean age was 7.83 ± 5.25 months while no statistical difference between age or sex distribution of patients with positive and negative viral etiology (p > 0...
November 24, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27870815/the-cape-town-clinical-decision-rule-for-streptococcal-pharyngitis-in-children
#3
Mark Emmanuel Engel, Karen Cohen, Ronald Gounden, Andre P Kengne, Dylan Dominic Barth, Andrew C Whitelaw, Veronica Francis, Motasim Badri, Annemie Stewart, James B Dale, Bongani M Mayosi, Gary Maartens
BACKGROUND: Existing clinical decision rules (CDR) to diagnose group A streptococcal (GAS) pharyngitis have not been validated in sub-Saharan Africa. We developed a locally applicable CDR while evaluating existing CDRs for diagnosing GAS pharyngitis in South African children. METHODS: We conducted a prospective cohort study and enrolled 997 children aged 3-15 years presenting to primary care clinics with a complaint of sore throat, and whose parents provided consent...
November 18, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27847579/a-clinical-analysis-of-secondary-surgery-in-trigeminal-neuralgia-patients-who-failed-prior-treatment
#4
Il Ho Kang, Bong Jin Park, Chang Kyu Park, Hridayesh Pratap Malla, Sung Ho Lee, Bong Arm Rhee
OBJECTIVE: Although many treatment modalities have been introduced for trigeminal neuralgia (TN), the long-term clinical results remain unsatisfactory. It has been particularly challenging to determine an appropriate treatment strategy for patients who have responded poorly to initial therapies. We analyzed the surgical outcomes in TN patients who failed prior treatments. METHODS: We performed a retrospective analysis of 37 patients with recurrent or persistent TN symptoms who underwent surgery at our hospital between January 2010 and December 2014...
November 2016: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/27846635/multilayered-closure-of-cerebrospinal-fluid-rhinorrhea-with-inlay-fascia-lata-autologous-fat-and-outlay-fascia-lata-our-experience
#5
Mehmet Akif Eryılmaz, Mitat Arıcıgil, Mehmet Akif Alan
BACKGROUND/AIMS: Since the initial use in 1981 by Wigand, different endoscopic endonasal surgery techniques have been proposed to close ventral skull base defects, all of which include multilayer closure involving vascularized mucoseptal flaps, autologous grafts, and synthetic materials. These methods are used individually or in combination, as required by the operative condition. METHODS: In this study we aimed to describe our endoscopic technique using inlay-outlay fascia lata and autologous fat with fibrin sealant to close spontaneous and traumatic cerebrospinal fluid (CSF) rhinorrhea...
November 16, 2016: ORL; Journal for Oto-rhino-laryngology and its related Specialties
https://www.readbyqxmd.com/read/27833876/a-short-term-subjective-and-objective-analysis-of-modified-endoscopic-lothrop-s-procedure-and-its-functional-outcome-our-experience
#6
D R Nayak, K Pai, S Nair, B Ramaswamy, H Sabhahit
To study the short-term functional outcomes of the endoscopic modified Lothrop procedure with well defined subjective and objective criteria. It's a retrospective cohort study with chart review carried out at a tertiary referral center. 31 patients with chronic frontal sinusitis who underwent endoscopic modified Lothrop's procedure with uncinate preservation during the period Jan 2011-2014 were followed up for a period of minimum 6 months. Assessment was done post-operatively based on subjective severity score and Kennedy's 5 point endoscopic criteria...
December 2016: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/27824967/asymmetric-radiotracer-activity-of-enlarged-cerebral-spinal-fluid-space-on-radionuclide-cisternography-with-spet-ct
#7
Julie C Bulman, Jason Wachsmann, Fangyu Peng
OBJECTIVE: Cerebrospinal fluid (CSF) leak is a well-known complication of skull or sinus surgery. Radionuclide cisternography has high sensitivity for detection of CSF leak, commonly performed in conjunction with radioactivity assay of nasal pledgets. Our objective was to highlight the usefulness of single photon emission tomography/computed tomography (SPET/CT) in radionuclide cisternography by presenting a case of a 41 years old man with right sided rhinorrhea following craniotomies and sinus surgery, who was subjected to radioactivity assay of nasal pledgets and radionuclide cisternography for suspected CSF leak...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27809892/spontaneous-cerebrospinal-fluid-leak-of-the-sphenoid-sinus-mimicking-allergic-rhinitis-and-managed-successfully-by-a-ventriculoperitoneal-shunt-a-case-report
#8
Youssef Darouassi, Mohamed Mliha Touati, Mehdi Chihani, Ali Akhaddar, Haddou Ammar, Brahim Bouaity
BACKGROUND: Spontaneous cerebrospinal fluid leaks are rare but may lead to confusion with other diseases in patients without history of trauma. We report a rare case unusual for two reasons. First, our patient was put under antiallergic medication for months before the diagnosis of spontaneous cerebrospinal fluid leak of the sphenoid sinus. Second, our patient was managed successfully by a ventriculoperitoneal shunt. CASE PRESENTATION: Our patient was a nonobese 49-year-old Arab man without history of trauma or surgery who presented with rhinorrhea...
November 3, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27803885/correlations-of-nasal-responses-to-leukotriene-d4-and-histamine-nasal-provocation-with-quality-of-life-in-allergic-rhinitis
#9
Zheng Zhu, Yanqing Xie, Weijie Guan, Yi Gao, Shu Xia, Xu Shi, Jinping Zheng
BACKGROUND: The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear. OBJECTIVE: To evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR. METHODS: Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week...
October 2016: Asia Pacific Allergy
https://www.readbyqxmd.com/read/27799071/evaluation-of-coldzyme%C3%A2-mouth-spray-on-prevention-of-upper-respiratory-tract-infections-in-a-boy-with-primary-immunodeficiency-a-case-report
#10
Mats Clarsund, Ulf Blom, Ann Gardulf
BACKGROUND: Primary immunodeficiencies include a variety of disorders that render patients more susceptible to infections. If left untreated, these infections may be fatal. Patients with primary antibody deficiencies are therefore given prophylactic immunoglobulin G replacement therapy. ColdZyme® Mouth Spray is a medical device intended to reduce the probability of catching a cold and/or can help shorten the duration of a cold, if used at an early stage of the infection, by forming a thin protective barrier on the pharyngeal mucous membrane...
October 31, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27789120/effect-of-curcumin-on-nasal-symptoms-and-airflow-in-patients-with-perennial-allergic-rhinitis
#11
Sihai Wu, Dajiang Xiao
BACKGROUND: Allergic rhinitis (AR) is a common disorder that can significantly affect patient quality of life. Previous studies have found that curcumin had anti-inflammatory and antioxidant effects and clinical benefits in cancer and asthma. OBJECTIVE: To determine the efficacy of curcumin in the treatment of AR and to explore the molecular mechanisms involved. METHODS: In a randomized, double-blind study, 241 patients with AR received either placebo or oral curcumin for 2 months...
October 24, 2016: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27779564/x-linked-malformation-and-cochlear-implantation
#12
Henrik Smeds, Jeremy Wales, Filip Asp, Ulrika Löfkvist, Babak Falahat, Britt-Marie Anderlid, Lena Anmyr, Eva Karltorp
OBJECTIVE: To evaluate if cochlear implantation is safe and constitutes an option for hearing rehabilitation of children with x-linked inner ear malformation. STUDY DESIGN: Retrospective patient review in combination with a multidisciplinary follow-up. SETTING: Tertiary referral hospital and cochlear implant program. PATIENTS: Ten children with severe-profound mixed hearing loss and radiological findings consistent with Incomplete Partition type 3 cochlear malformation received cochlear implants during the years 2007 to 2015...
October 21, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27777594/clinical-validation-of-controlled-exposure-to-birch-pollen-in-the-environmental-exposure-unit-eeu
#13
Anne K Ellis, Mena Soliman, Lisa M Steacy, Daniel E Adams, Barnaby Hobsbawn, Terry J B Walker
BACKGROUND: The Environmental Exposure Unit (EEU) in Kingston, Ontario, Canada is a controlled allergen challenge facility (CACF) that has been previously clinically validated for the use of ragweed and grass pollen in clinical studies. In this study we aim to validate the use of birch pollen to challenge allergic participants. METHODS: A total of 59 volunteers were screened and 38 birch allergic participants and ten non-allergics completed the study, outside of tree pollen season...
2016: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/27773901/a-case-of-bacterial-meningitis-caused-by-methicillin-resistant-staphylococcus-lugdunensis-after-surgery
#14
Yasuhiro Sasaki, Ayumi Kanamaru, Hisae Uchida, Masataka Yano, Hiroshi Tada
An 51-year-old man had undergone surgery for Rathke's cleft cyst by transsphenoidal approach on October 2015. After the surgery, cerebrospinal fluid (CSF) rhinorrhea arose. Surgical treatment of CSF rhinorrhea was performed by the same approach. Ten days after reoperation, he suffered from severe headache, high fever, and nuchal rigidity. CSF findings indicated bacterial meningitis. CSF culture showed methicillin-resistant Staphylococcus lugdunensis. He received vancomycin intravenously for 19 days and recovered from the bacterial meningitis with no serious complication...
November 29, 2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27759801/unusual-motor-and-non-motor-symptoms-and-signs-in-the-early-stage-of-parkinson-s-disease
#15
Hélio A G Teive, Délcio C Bertucci, Renato P Munhoz
Objective: Patients with Parkinson's disease (PD) may present with unusual motor and non-motor symptoms and signs in the early stage of the disease. Methods: Cases were collected over a five-year period at two tertiary movement disorders clinics. All had a diagnosis of PD with unusual presentations defined retrospectively as the presence of complaints not objectively related to any of the classic cardinal signs of parkinsonism or the typical early non-motor features of PD...
October 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27729302/unusual-association-between-spontaneous-lateral-sphenoid-encephalocele-and-chiari-malformation-type-i-endoscopic-repair-through-a-transpterygoid-approach
#16
Daniele Starnoni, Roy Thomas Daniel, Mercy George, Mahmoud Messerer
BACKGROUND: Spontaneous meningoencephaloceles of the lateral sphenoid sinus are rare entities and their peculiar location represent a surgical challenge due to the importance of a wide exposure and skull base reconstruction. They are thought to arise from congenital base defect of the lateral sphenoid or in some cases have been postulated to represent a rare manifestation of altered CSF dynamics. We report the first case in literature of a Chiari malformation type I and a lateral sphenoid encephaloceles revising the theoretical etiology and surgical technique of endoscopic repair...
October 8, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27726976/sinonasal-symptom-assessment-by-the-self-reported-dynachron-questionnaire-before-or-after-consultation
#17
D T Nguyen, C Rumeau, M Felix-Ravelo, P-L Nguyen-Thi, R Jankowski
OBJECTIVE: Assessment of sinonasal symptoms on a self-reported questionnaire is thoroughly subjective, but indispensable for quantifying symptoms. The present study sought to compare responses on the DyNaChron questionnaire just before and just after consultation for chronic sinonasal dysfunction. MATERIALS AND METHODS: 78 patients (mean age, 43.1±16.9 years) consulting for chronic sinonasal dysfunction took part in a prospective study, responding to the computerized version of the DyNaChron self-reported questionnaire, in a dedicated room, just before and just after medical interview and physical examination...
October 7, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27712763/pathogenesis-of-aspirin-induced-reactions-in-aspirin-exacerbated-respiratory-disease
#18
Katherine N Cahill, Tanya M Laidlaw
The acute clinical symptoms that develop following the oral ingestion of aspirin, or any other inhibitor of cyclooxygenase-1, are well established in aspirin-exacerbated respiratory disease: nasal congestion, rhinorrhea, and bronchospasm. Less commonly, gastrointestinal distress, rash, angioedema, or urticaria also develops. However, the pathobiology that drives these clinical reactions is poorly understood. Use of an intranasal aspirin challenge protocol or administration of premedications inhibiting the leukotriene pathway decreases the severity of clinical reaction, which suggests the involvement of both local effector cells and cysteinyl leukotrienes in the pathogenesis of aspirin-induced reactions...
November 2016: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27708578/adherence-and-patients-experiences-with-the-use-of-capecitabine-in-daily-practice
#19
Lonneke Timmers, Christel C L M Boons, Dirk Mangnus, Peter M Van de Ven, Pieter H Van den Berg, Aart Beeker, Eleonora L Swart, Richard J Honeywell, Godefridus J Peters, Epie Boven, Jacqueline G Hugtenburg
Introduction: Capecitabine is a widely prescribed oral anticancer agent. We studied medication adherence and explored its use in daily practice from a patients' perspective. Patients and Methods: Patients (n = 92) starting capecitabine were followed up to five 3-week cycles. Adherence was assessed using a pill count, pharmacy data and dosing information from the patients' medical file. Self-reported adherence was measured using the Medication Adherence Report Scale (MARS). At baseline and during week 2 of cycles 1, 3, and 5, patients filled out questionnaires about quality of life, symptoms, attitude toward medicines and disease and use in daily practice...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27704652/epidemiology-clinical-characteristics-laboratory-findings-and-severity-of-respiratory-syncytial-virus-acute-lower-respiratory-infection-in-malaysian-children-2008-2013
#20
Khuen F Ng, Kah K Tan, Zhi H Sam, Grace Ss Ting, Wan Y Gan
AIM: The aim of this study is to describe epidemiology, clinical features, laboratory data and severity of respiratory syncytial virus (RSV) acute lower respiratory infection (ALRI) in Malaysian children and to determine risk factors associated with prolonged hospital stay, paediatric intensive care unit (PICU) admission and mortality. METHODS: Retrospective data on demographics, clinical presentation, outcomes and laboratory findings of 450 children admitted into Tuanku Jaafar Hospital in Seremban, Malaysia from 2008 to 2013 with documented diagnosis of RSV ALRI were collected and analysed...
October 5, 2016: Journal of Paediatrics and Child Health
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