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Gary K Owens vsmc

Martin R Bennett, Sanjay Sinha, Gary K Owens
The historical view of vascular smooth muscle cells (VSMCs) in atherosclerosis is that aberrant proliferation of VSMCs promotes plaque formation, but that VSMCs in advanced plaques are entirely beneficial, for example preventing rupture of the fibrous cap. However, this view has been based on ideas that there is a homogenous population of VSMCs within the plaque, that can be identified separate from other plaque cells (particularly macrophages) using standard VSMC and macrophage immunohistochemical markers...
February 19, 2016: Circulation Research
Olga A Cherepanova, Nataliya A Pidkovka, Olga F Sarmento, Tadashi Yoshida, Qiong Gan, Eser Adiguzel, Michelle P Bendeck, Judith Berliner, Norbert Leitinger, Gary K Owens
Phenotypic switching of vascular smooth muscle cells (VSMCs) is known to play a critical role in the development of atherosclerosis. However, the factors present within lesions that mediate VSMC phenotypic switching are unclear. Oxidized phospholipids (OxPLs), including 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine (POVPC), are active components of minimally modified low density lipoprotein and have been previously shown to induce multiple proatherogenic events in endothelial cells and macrophages, but their effects on VSMCs have been largely unexplored until recently...
March 13, 2009: Circulation Research
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