keyword
https://read.qxmd.com/read/38535834/hepatic-gene-expression-of-angiogenic-and-regeneration-markers-in-cats-with-congenital-portosystemic-shunts-cpss
#21
JOURNAL ARTICLE
Michael S Tivers, Samantha M Mirczuk, Abigail Charlesworth, Lauren Wood, Emi N Barker, Victoria J Lipscomb, Robert C Fowkes
Congenital portosystemic shunts (CPSS) are vascular anomalies resulting in liver hypoplasia and hepatic insufficiency. Cats with CPSS typically show signs of hepatic encephalopathy associated with increased ammonia, inflammatory cytokines, and oxidative stress. Surgical attenuation of the CPSS results in improved liver function, resolution of clinical signs, and increased portal blood flow. Hepatic gene expression has not previously been investigated in cats with CPSS. Here, we compared the hepatic expression of genes involved in the urea cycle ( CPS1 , NAGS ), angiogenesis ( VEGFR2 , NPPA , NPR1 , NPPC , NPR2 , HIF1a ), liver regeneration ( SERPINB1 , HGF , TGFβ ), and metabolism ( FGF21 ) from a small series of cats ( n = 18) with CPSS to that of control cats ( n = 10)...
February 26, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535833/correlation-between-oxidative-stress-markers-and-periodontal-disease-in-dogs
#22
JOURNAL ARTICLE
Cosmin Petru Peștean, Hélène Pocquet, Daria Antonia Dumitraș, Andreea Georgiana Morohoschi, Laura Cristina Ștefănuț, Sanda Andrei
In dogs, periodontal disease (PD) is a highly common condition whose prevalence rises significantly with age. Studies on rats with experimentally induced PD and human clinical trials have found an association between oxidative stress (OS) and PD, as has been observed in many other inflammatory disorders. The objective of this research was to assess the main indicators of oxidative stress detected in the saliva of dogs and to compare them to the degree of inflammation and tartar amount on their teeth and gums...
February 22, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535820/the-effects-of-t-2-toxin-deoxynivalenol-and-fumonisin-b1-on-oxidative-stress-related-genes-in-the-kidneys-of-laying-hens
#23
JOURNAL ARTICLE
Benjamin Kövesi, Szabina Kulcsár, Zsolt Ancsin, Márta Erdélyi, Erika Zándoki, Patrik Gömbös, Krisztián Balogh, Miklós Mézes
In the context of nephrotoxic risks associated with environmental contaminants, this study focused on the impact of mycotoxin exposure on the renal health of laying hens, with particular attention to oxidative stress pathways. Sixty laying hens were assigned to three groups-a control group (CON), a low-dose mycotoxin group (LOW), and a high-dose mycotoxin group (HIGH)-and monitored for 72 h. Mycotoxin contamination involved T-2/HT-2 toxin, DON/3-AcDON/15-AcDON, and FB1 at their EU-recommended levels (low mix) and at double doses (high mix)...
March 16, 2024: Toxins
https://read.qxmd.com/read/38535817/red-orange-and-lemon-extract-ameliorates-the-renal-oxidative-stress-and-inflammation-induced-by-ochratoxin-a-through-the-modulation-of-nrf2
#24
JOURNAL ARTICLE
Consiglia Longobardi, Sara Damiano, Simona Fabroni, Serena Montagnaro, Valeria Russo, Emanuela Vaccaro, Antonio Giordano, Salvatore Florio, Roberto Ciarcia
BACKGROUND: The presence of ochratoxin A (OTA) in food and feed is a public health concern. OTA intoxication is caused by several mechanisms, one of which consists of the alteration of the antioxidant activity of the cell due to the oxidative stress (OS). In this context, the use of natural antioxidant substances could be a potential biological decontamination method of mitigating the negative outcomes induced by OTA. METHODS: we aimed to investigate how a red orange and lemon extract (RLE), rich in anthocyanins, would affect OTA-treated rats...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535815/integration-of-multi-omics-histological-and-biochemical-analysis-reveals-the-toxic-responses-of-nile-tilapia-liver-to-chronic-microcystin-lr-exposure
#25
JOURNAL ARTICLE
Yichao Li, Huici Yang, Bing Fu, Gen Kaneko, Hongyan Li, Jingjing Tian, Guangjun Wang, Mingken Wei, Jun Xie, Ermeng Yu
Microcystin-LR (MC-LR) is a cyanobacterial metabolite produced during cyanobacterial blooms and is toxic to aquatic animals, and the liver is the main targeted organ of MC-LR. To comprehensively understand the toxicity mechanism of chronic exposure to environmental levels of MC-LR on the liver of fish, juvenile Nile tilapia were exposed to 0 μg/L (control), 1 μg/L (M1), 3 μg/L (M3), 10 μg/L (M10), and 30 μg/L (M30) MC-LR for 60 days. Then, the liver hepatotoxicity induced by MC-LR exposure was systematically evaluated via histological and biochemical determinations, and the underlying mechanisms were explored through combining analysis of biochemical parameters, multi-omics (transcriptome and metabolome), and gene expression...
March 14, 2024: Toxins
https://read.qxmd.com/read/38535496/mitigation-of-salt-stress-in-rice-by-the-halotolerant-plant-growth-promoting-bacterium-enterobacter-asburiae-d2
#26
JOURNAL ARTICLE
Zican Ning, Kexin Lin, Mengya Gao, Xiao Han, Qingjie Guan, Xiang Ji, Shuyu Yu, Lei Lu
Salinity is a major abiotic stress that seriously affects crop growth worldwide. In this work, we aimed to isolate potential halotolerant plant growth-promoting rhizobacteria (PGPR) to mitigate the adverse impacts of salt stress in rice. An isolate, D2, with multiple plant growth-promoting (PGP) characteristics was identified as Enterobacter asburiae D2. Strain D2 could produce indole-3-acetic acid and siderophore. It also exhibited phosphate solubilization and 1-aminocyclopropane-1-carboxylic deaminase activity...
March 1, 2024: Journal of Xenobiotics
https://read.qxmd.com/read/38535471/antioxidant-activity-inhibition-of-intestinal-cancer-cell-growth-and-polyphenolic-compounds-of-the-seagrass-posidonia-oceanica-s-extracts-from-living-plants-and-beach-casts
#27
JOURNAL ARTICLE
Alkistis Kevrekidou, Andreana N Assimopoulou, Varvara Trachana, Dimitrios Stagos, Paraskevi Malea
The aim of the present study was to investigate the use of Posidonia oceanica for making products beneficial for human health. Firstly, we demonstrated that the antioxidant defense (i.e., SOD and APX activity) of P. oceanica 's living leaves (LP) has low efficacy, as they partly neutralize the produced H2 O2 . However, high H2 O2 levels led LP to produce, as a response to oxidative stress, high phenolic content, including chicoric acid, p -coumaric acid, caftaric acid, trans -cinnamic and rutin hydrate, as shown by UHPLC-DAD analysis...
March 11, 2024: Marine Drugs
https://read.qxmd.com/read/38535440/a-standardized-extract-of-microalgae-phaeodactylum-tricornutum-mi136-inhibit-d-gal-induced-cognitive-dysfunction-in-mice
#28
JOURNAL ARTICLE
Jonathan Maury, Antoine Delbrut, Vanessa Villard, Rémi Pradelles
The microalgae Phaeodactylum tricornutum (PT) is distinguished by its rich nutrient profile, characterized by well-documented neuroprotective activities, including fucoxanthin (FX), a major carotenoid and polyunsaturated omega-3 fatty acids (n-3 PUFA). The current study aims to evaluate the protective effects of a standardized extract of PT (Mi136) containing 2% FX on cognitive function, oxidative stress, and inflammation parameters in a mouse model of accelerated aging. Seventy-two (72) male mice were randomly assigned to the blank control group (BC), negative control group (NC), and four similar microalgae extract of PT groups (branded as BrainPhyt™) with different human equivalent doses to evaluate potential dose-response effects...
February 21, 2024: Marine Drugs
https://read.qxmd.com/read/38535321/palmitate-compromises-c6-astrocytic-cell-viability-and-mitochondrial-function
#29
JOURNAL ARTICLE
Luisa O Schmitt, Antonella Blanco, Sheila V Lima, Gianni Mancini, Natalia F Mendes, Alexandra Latini, Joana M Gaspar
Consumption of high-fat diets (HFD) is associated with brain alterations, including changes in feeding behavior, cognitive decline, and dementia. Astrocytes play a role in HFD-induced neuroinflammation and brain dysfunction; however, this process is not entirely understood. We hypothesized that exposure to saturated fatty acids can compromise astrocyte viability and mitochondrial function. The C6 (astrocytes) cell line was treated with palmitate or stearate (200 µM and 400 µM) for 6 h. Cell viability, morphology, inflammatory markers, and oxidative stress were evaluated...
March 12, 2024: Metabolites
https://read.qxmd.com/read/38535316/daily-injection-of-the-%C3%AE-2-adrenergic-agonist-clenbuterol-improved-muscle-glucose-metabolism-glucose-stimulated-insulin-secretion-and-hyperlipidemia-in-juvenile-lambs-following-heat-stress-induced-intrauterine-growth-restriction
#30
JOURNAL ARTICLE
Rachel L Gibbs, James A Wilson, Rebecca M Swanson, Joslyn K Beard, Zena M Hicks, Haley N Beer, Eileen S Marks-Nelson, Ty B Schmidt, Jessica L Petersen, Dustin T Yates
Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction ( IUGR ) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that received daily injections of saline or the β2 agonist clenbuterol from birth to 60 days were compared with controls from pair-fed thermoneutral pregnancies. As juveniles, IUGR lambs exhibited systemic inflammation and robust metabolic dysfunction, including greater ( p < 0...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38535310/transcriptome-in-liver-of-periparturient-dairy-cows-differs-between-supplementation-of-rumen-protected-niacin-and-rumen-protected-nicotinamide
#31
JOURNAL ARTICLE
Yuanjie Zhang, Rongrong Li, Xue'er Du, Zhijie Cui, Xingwei Jiang, Lamei Wang, Junhu Yao, Shimin Liu, Jianguo Wang, Chuanjiang Cai, Yangchun Cao
To investigate the difference between rumen-protected niacin (RPN) and rumen-protected nicotinamide (RPM) in the transcriptome of genes relating to the lipid metabolism of the liver of periparturient dairy cows, 10 healthy Chinese Holstein cows were randomly divided into two groups and fed diets supplemented with 18.4 g/d RPN or 18.7 g/d RPM, respectively. The experiment lasted from 14 days before to 21 days after parturition. Liver biopsies were taken 21 days postpartum for transcriptomic sequencing. In addition, human LO2 cells were cultured in a medium containing 1...
March 1, 2024: Metabolites
https://read.qxmd.com/read/38535307/automated-spectrophotometric-assays-for-the-measurement-of-ammonia-and-bicarbonate-in-saliva-of-horses-analytical-validation-and-changes-in-equine-gastric-ulcer-syndrome-egus
#32
JOURNAL ARTICLE
Alberto Muñoz-Prieto, Eva Llamas-Amor, María Dolores Contreras-Aguilar, Ignacio Ayala, María Martín Cuervo, José Joaquín Cerón, Sanni Hansen
Ammonia (NH3 ) and bicarbonate (HCO3 ) have been related to gastric ulcers in humans. Ammonia is considered a possible cause of gastric ulcers, whereas bicarbonate has a protective function. The presence of ulcers in the stomach of horses is defined as Equine Gastric Ulcer Syndrome (EGUS), which is a frequent disease in this species, and it has been associated with changes in saliva composition, such as in analytes related to inflammation, immune system and oxidative stress. The objectives of this study were (1) to perform an analytical validation of two automated spectrophotometric assays, one for ammonia and one for bicarbonate, in the horses' saliva and (2) to evaluate their possible variations with EGUS...
February 28, 2024: Metabolites
https://read.qxmd.com/read/38535295/exercise-alleviates-aging-of-adipose-tissue-through-adipokine-regulation
#33
REVIEW
Dandan Jia, Huijie Zhang, Tiemin Liu, Ru Wang
Adipose tissue undergoes changes with aging, leading to increased adiposity, inflammatory cell infiltration, reduced angiogenesis, heightened oxidative stress, and alterations in its metabolic function. Regular exercise has been recognized as a powerful intervention that can positively influence adipose tissue health and mitigate the effects of aging. However, the molecular mechanisms underlying the benefits of regular exercise on aging adipose tissue function remain poorly understood. Adipokines released through regular exercise play a potential role in mitigating adipose tissue aging, enhancing the metabolism of glucose and lipids, reducing inflammation and fibrosis, and promoting fat browning and thermogenesis...
February 22, 2024: Metabolites
https://read.qxmd.com/read/38535229/the-oxidative-stress-response-highly-depends-on-glucose-and-iron-availability-in-aspergillus-fumigatus
#34
JOURNAL ARTICLE
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H2 O2 treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions...
March 18, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535221/copper-sulfate-combined-with-photodynamic-therapy-enhances-antifungal-effect-by-downregulating-aif1
#35
JOURNAL ARTICLE
Meimei Zhang, Qiyuan An, Yingzhe Wang, Shigan Ye, Xiaoliang Zhu
Candida albicans is a clinically significant opportunistic fungus that is generally treated with antifungal drugs such as itraconazole and fluconazole. However, the recent emergence of fungal resistance has made treatment increasingly difficult. Therefore, novel antifungal treatment methods are urgently required. Hexanol ethosome photodynamic therapy (HE-PDT) is a method that uses photosensitizers (PS), such as hexanol ethosome, to exert antifungal effects, and can be used to treat resistant fungal strains...
March 14, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535187/comparative-transcriptome-profiles-of-the-response-of-mycelia-of-the-genus-morchella-to-temperature-stress-an-examination-of-potential-resistance-mechanisms
#36
JOURNAL ARTICLE
Yihong Yue, Haibo Hao, Qian Wang, Tingting Xiao, Yuchen Zhang, Hui Chen, Jinjing Zhang
Temperature and moisture belong to the most important environmental factors affecting the growth and development of fungi. However, the effect of temperature on the mycelia of the edible Morchella mushrooms has not been determined. Here, a comprehensive analysis was performed to determine the influence of culture temperature on 13 strains of mycelia of three Morchella species ( Morchella sextelata , Morchella septimelata , and Morchella importuna ) at 5 °C, 10 °C, 15 °C, 20 °C, 25 °C, and 30 °C...
February 27, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535181/exploring-mechanisms-of-antifungal-lipopeptide-iturin-a-from-bacillus-against-aspergillus-niger
#37
JOURNAL ARTICLE
Shiyi Wang, Min Xu, Ye Han, Zhijiang Zhou
The control of Aspergillus niger ( A. niger ) is of great significance for the agricultural economy and food safety. In this study, the antifungal effect and mechanism of iturin A from Bacillus amyloliquefaciens (CGMCC No. 8473) against A. niger (ATCC 16404) were investigated using biochemical analyses and proteomics. Changes in a mycelium treated with iturin A were observed using scanning electron microscopy and transmission electron microscopy, including mycelial twisting and collapse, organelle disintegration, and intracellular vacuolization...
February 24, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534974/protective-effects-of-propolis-and-chitosan-nanoparticles-against-ibuprofen-induced-hepatotoxicity-in-albino-rats
#38
JOURNAL ARTICLE
Fajer M AlKandari, Hussein S Mohamed, Sayed A Ahmed, Basant Mahmoud, Asmaa M Mahmoud
Post-marketing hepatotoxicity findings are more common or occur much later. NSAIDs (non-steroidal anti-inflammatory drugs) like ibuprofen are consumed in large quantities around the world. NSAIDs have a low incidence of hepatotoxicity but their wide use makes them a major contributor to drug-induced liver injury. Hepatitis is linked to systemic oxidative stress which results in cellular necrosis and fibrosis, as well as tissue lipoprotein peroxidation and glutathione depletion. Given the lack of safe and effective anti-hepatitis drugs in medicine today, natural substances appear to be a promising and safe alternative...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534973/the-role-of-oxidative-stress-in-tb-meningitis-and-therapeutic-options
#39
REVIEW
John Dawi, Aishvaryaa Shree Mohan, Yura Misakyan, Scarlet Affa, Edgar Gonzalez, Karim Hajjar, David Nikoghosyan, Sabrina Fardeheb, Christopher Tuohino, Vishwanath Venketaraman
Meningitis is an inflammatory condition affecting the meninges surrounding the brain and spinal cord. Meningitis can be triggered by various factors, including infectious agents like viruses and bacteria and non-infectious contributors such as cancer or head injuries. The impact of meningitis on the central nervous system involves disruptions in the blood-brain barrier, cellular infiltrations, and structural alterations. The clinical features that differentiate between tuberculous meningitis (TBM) and non-tuberculous meningitis (NTM) are discussed in this review and aid in accurate diagnosis...
February 29, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534765/antioxidant-glutathione-analogues-upf1-and-upf17-modulate-the-expression-of-enzymes-involved-in-the-pathophysiology-of-chronic-obstructive-pulmonary-disease
#40
JOURNAL ARTICLE
Ingrid Oit-Wiscombe, Ursel Soomets, Alan Altraja
Increased oxidative stress (OS) and systemic inflammation are key players in the pathophysiology of chronic obstructive pulmonary disease (COPD). We aimed to clarify the effects of synthetic glutathione (GSH) analogue peptides UPF1 and UPF17 on the mRNA levels of enzymes involved in systemic inflammation and GSH metabolism in peripheral blood mononuclear cells (PBMCs) from patients with acute exacerbation of COPD (AE-COPD) and stable COPD along with non-obstructive smokers and non-smokers. UPF1 and UPF17 increased the expression of enzymes involved in the formation of the antioxidant capacity: superoxide dismutase 1 (SOD1) and the catalytic subunit of glutamyl-cysteine ligase (GCLC) in patients with AE-COPD and stable COPD, but also in non-obstructive smokers and non-smokers...
March 12, 2024: Current Issues in Molecular Biology
keyword
keyword
1180
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.