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Oxidative stress

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https://www.readbyqxmd.com/read/28434171/peroxidatic-cysteine-residue-of-peroxiredoxin-2-separated-from-human-red-blood-cells-treated-by-tert-butyl-hydroperoxide-is-hyperoxidized-into-sulfinic-and-sulfonic-acids
#1
Yo-Ichi Ishida, Mariko Aki, Sohta Fujiwara, Masami Nagahama, Yuki Ogasawara
Peroxiredoxin 2 (Prx2) is a redox enzyme that is abundantly expressed in red blood cells (RBCs) and has been the focus of clinical attention for monitoring the oxidative status. We previously developed a method to quantify the reduced and hyperoxidized forms of Prx2 in human RBCs using reverse-phase high-performance liquid chromatography (HPLC). In the present study, we investigated the hyperoxidative status of Prx2 at the molecular level in a post-translational modification analysis using a liquid chromatography-tandem mass spectrometry (LC-MS/MS) system...
April 22, 2017: Human Cell
https://www.readbyqxmd.com/read/28434137/cholesterol-hydroperoxide-generation-translocation-and-reductive-turnover-in-biological-systems
#2
Albert W Girotti, Witold Korytowski
Cholesterol is like other unsaturated lipids in being susceptible to peroxidative degradation upon exposure to strong oxidants like hydroxyl radical or peroxynitrite generated under conditions of oxidative stress. In the eukaryotic cell plasma membrane, where most of the cellular cholesterol resides, peroxidation leads to membrane structural and functional damage from which pathological states may arise. In low density lipoprotein, cholesterol and phospholipid peroxidation have long been associated with atherogenesis...
April 22, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28434075/associations-of-self-reported-smoking-cotinine-levels-and-epigenetic-smoking-indicators-with-oxidative-stress-among-older-adults-a-population-based-study
#3
Xu Gao, Xīn Gào, Yan Zhang, Lutz Philipp Breitling, Ben Schöttker, Hermann Brenner
Tobacco smoking and oxidative stress (OS) are both related to a wide spectrum of adverse age-related health outcomes, but their association is not yet well-established. We examined the associations of self-reported smoking indicators, serum cotinine levels and smoking-related DNA methylation biomarkers with two urinary proxy markers of OS, 8-isoprostane (8-iso) and 8-hydroxy-2'-deoxyguanosine (8-oxodG), in two independent subsets of older adults recruited in Germany (discovery set: n = 978, validation set: n = 531)...
April 22, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28434034/erratum-to-houttuynia-cordata-aqueous-extract-attenuated-glycative-and-oxidative-stress-in-heart-and-kidney-of-diabetic-mice
#4
Cheng-Chin Hsu, Hui-Ting Yang, Jing-Jing Ho, Mei-Chin Yin, Jen-Ying Hsu
No abstract text is available yet for this article.
April 22, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28434003/cytotoxic-effects-of-transthyretin-aggregates-in-an-epidermoid-cell-line
#5
Vai Hong Fong, Amandio Vieira
OBJECTIVE: Skin amyloid deposits can occur as part of systemic amyloidoses including those involving misfolded- aggregated transthyretins (agTTR). Pathological effects of agTTR on the skin are not well understood. The main objective of the current study was to examine the toxicity of agTTR upon a human keratinocyte cell line. METHODS: Cells were analyzed for indicators of oxidative stress after treatment with normal soluble TTR or the same pre-aggregation concentration of agTTR...
April 22, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28433943/acute-lung-injury-leads-to-depression-like-symptoms-through-upregulation-of-neutrophilic-and-neuronal-nadph-oxidase-signaling-in-a-murine-model
#6
Ahmed Nadeem, Nahid Siddiqui, Naif O Al-Harbi, Sabry M Attia, Shakir D AlSharari, Sheikh F Ahmad
There is an increased prevalence of comorbid major depressive disorders with a number of inflammatory conditions which is thought to result from activation of the immune system. Acute lung injury (ALI) in humans has been also shown to be associated with depression previously. However, no study has explored the mechanism behind ALI-induced depression. NADPH oxidase (NOX-2) derived reactive oxygen species (ROS) are associated with neuropsychiatric disorders including depression. ROS generation via NOX-2 is also shown to be involved in the pathogenesis of ALI...
April 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28433940/a-novel-dual-ratiometric-response-fluorescent-probe-for-so2-clo-detection-in-cells-and-in%C3%A2-vivo-and-its-application-in-exploring-the-dichotomous-role-of-so2-under-the-clo-induced-oxidative-stress
#7
Kun Dou, Qiang Fu, Guang Chen, Fabiao Yu, Yuxia Liu, Ziping Cao, Guoliang Li, Xianen Zhao, Lian Xia, Lingxin Chen, Hua Wang, Jinmao You
Intracellular reactive sulfur species and reactive oxygen species play vital roles in immunologic mechanism. As an emerging signal transmitter, SO2 can be generated as the anti-oxidant, while SO2 is also a potential oxidative stress-inducer in organism. Aiming to elucidate in-depth the dichotomous role of SO2 under oxidative stress, we designed a dual-response fluorescent probe that enabled the respective or successive detection of SO2 and ClO(-). The probe itself emits the red fluorescence (625 nm) which can largely switch to blue (410 nm) and green fluorescence (500 nm) respectively in response to SO2 and ClO(-), allowing the highly selective and accurate ratiometric quantification for both SO2 and ClO(-) in cells...
April 14, 2017: Biomaterials
https://www.readbyqxmd.com/read/28433935/distinct-on-off-fluorescence-signals-from-dual-responsive-activatable-nanoprobes-allows-detection-of-inflammation-with-improved-contrast
#8
Mathieu L Viger, Guillaume Collet, Jacques Lux, Viet Anh Nguyen Huu, Monica Guma, Alexandra Foucault-Collet, Jason Olejniczak, Shivanjali Joshi-Barr, Gary S Firestein, Adah Almutairi
Visualization of biochemical changes associated with disease is of great clinical significance, as it should allow earlier, more accurate diagnosis than structural imaging, facilitating timely clinical intervention. Herein, we report combining stimuli-responsive polymers and near-infrared fluorescent dyes (emission max: 790 nm) to create robust activatable fluorescent nanoprobes capable of simultaneously detecting acidosis and oxidative stress associated with inflammatory microenvironments. The spectrally-resolved mechanism of fluorescence activation allows removal of unwanted background signal (up to 20-fold reduction) and isolation of a pure activated signal, which enables sensitive and unambiguous localization of inflamed areas; target-to-background ratios reach 22 as early as 3 h post-injection...
March 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/28433816/l-carnitine-prevents-memory-impairment-induced-by-chronic-rem-sleep-deprivation
#9
Karem H Alzoubi, Abeer M Rababah, Amani Owaisi, Omar F Khabour
Sleep deprivation (SD) negatively impacts memory, which was related to oxidative stress induced damage. L-carnitine is a naturally occurring compound, synthesized endogenously in mammalian species and known to possess antioxidant properties. In this study, the effect of L-carnitine on learning and memory impairment induced by rapid eye movement sleep (REM-sleep) deprivation was investigated. REM-sleep deprivation was induced using modified multiple platform model (8hrs/day, for 6 weeks). Simultaneously, L-carnitine was administered (300mg/kg/day) intraperitoneally for 6 weeks...
April 19, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28433804/crocin-attenuates-hemorrhagic-shock-induced-oxidative-stress-and-organ-injuries-in-rats
#10
Long Yang, Xiujuan Dong
We aimed to evaluate the effect of natural antioxidant crocin in alleviating hemorrhagic shock (HS)-induced organ damages. HS rats were treated with crocin during resuscitation. Mortality at 12h and 24h post resuscitation was documented. HS and resuscitation induced organ injuries, as characterized by elevated wet/dry ratio, quantitative assessment ratio, blood urea nitrogen, creatinine, aspartate aminotransferase and alanine aminotransferase, whereas rats received crocin treatment demonstrated improvements in all the above characteristics...
April 13, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28433747/chemical-composition-of-ocimum-sanctum-by-lc-esi-ms-ms-analysis-and-its-protective-effects-against-smoke-induced-lung-and-neuronal-tissue-damage-in-rats
#11
M P Venuprasad, Hemanth Kumar Kandikattu, Sakina Razack, Narayanappa Amruta, Farhath Khanum
Smoke induced oxidative stress is known to cause various cancers and associated health problems including lung cancer. Herbal extracts have been reported as antioxidant supplements which attenuate free radical induced oxidative damage of tissues, among which Ocimum sanctum has been reported as the elixir of life due to its innumerable health benefits. In the present study, we investigated the protective effect of O. sanctum against cracker smoke induced lung and brain tissue damage. The results of the study demonstrate that O...
April 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28433717/response-a-chronic-effects-of-pbde-47-up-regulations-of-hsp60-and-hsp70-expression-in-freshwater-bivalve-anodonta-woodiana
#12
Xichao Xia, Shipeng Xue, Xiying Wang, Qingyuan Zhang, Chuanfeng Huang, Lianghong Guo, Lunguang Yao
Heat shock proteins (HSPs) play an important role in adaption of environmental stress by protein folding, membrane translocation, degradation of misfolded proteins and other regulatory processes. Our previous study showed oxidative stress generated from polybrominated diphenyl ether-47 (PBDE-47) could cause an acute toxicity on freshwater bivalve Anodonta Woodiana, but the effect of chronic toxicity need to be elucidated. In order to further investigate the chronic effect of PBDE-47, clams A. Woodiana were randomly divided into the PBDE-47 treated group administrated with PBDE-47 at a concentration 3...
April 19, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28433662/iron-and-thiol-redox-signaling-in-cancer-an-exquisite-balance-to-escape-ferroptosis
#13
REVIEW
Shinya Toyokuni, Fumiya Ito, Kyoko Yamashita, Yasumasa Okazaki, Shinya Akatsuka
Epidemiological data indicate a constant worldwide increase in cancer mortality, although the age of onset is increasing. Recent accumulation of genomic data on human cancer via next-generation sequencing confirmed that cancer is a disease of genome alteration. In many cancers, the Nrf2 transcription system is activated via mutations either in Nrf2 or Keap1 ubiquitin ligase, leading to persistent activation of the genes with antioxidative functions. Furthermore, deep sequencing of passenger mutations is clarifying responsible cancer causative agent(s) in each case, including aging, APOBEC activation, smoking and UV...
April 19, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28433652/ketamine-potentiates-oxidative-stress-and-influences-behaviour-and-inflammation-in-response-to-lipolysaccharide-lps-exposure-in-early-life
#14
Gislaine Z Réus, Lutiana R Simões, Gabriela D Colpo, Giselli Scaini, Jean P Oses, Jaqueline S Generoso, Alan R Prossin, Rima Kaddurah-Daouk, João Quevedo, Tatiana Barichello
Immune activation (IA) during the early neonatal period is a risk factor for the development of schizophrenia. Lipopolysaccharide (LPS) injected in neonates lead to behavioral and brain changes that persist to adult life. We investigated oxidative stress, levels of cytokines, and the locomotor activity of IA in a schizophrenia animal model in which neonatal male Wistar rats were administered with an injection of LPS (50 μg/kg) on postnatal day 3 and different doses of ketamine (5, 15 and 25 mg/kg) for 7 days during adulthood...
April 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28433632/role-of-microrna-130b-in-placental-pgc-1%C3%AE-tfam-mitochondrial-biogenesis-pathway
#15
Shaoning Jiang, April M Teague, Jeanie B Tryggestad, Steven D Chernausek
Diabetes during pregnancy is associated with abnormal placenta mitochondrial function and increased oxidative stress, which affect fetal development and offspring long-term health. Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) is a master regulator of mitochondrial biogenesis and energy metabolism. The molecular mechanisms underlying the regulation of PGC-1α in placenta in the context of diabetes remain unclear. The present study examined the role of microRNA 130b (miR-130b-3p) in regulating PGC-1α expression and oxidative stress in a placental trophoblastic cell line (BeWo)...
April 19, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28433610/paraoxonases-and-infectious-diseases
#16
REVIEW
Jordi Camps, Simona Iftimie, Anabel García-Heredia, Antoni Castro, Jorge Joven
The paraoxonases (PON1, PON2 and PON3) are an enzyme family with a high structural homology. All of them have lactonase activity and degrade lipid peroxides in lipoproteins and cells. As such, they play a role in protection against oxidation and inflammation. Infectious diseases are often associated with oxidative stress and an inflammatory response. Infection and inflammation trigger a cascade of reactions in the host, known as the acute-phase response. This response is associated with dramatic changes in serum proteins and lipoproteins, including a decrease in serum PON1 activity...
April 19, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28433594/favouring-no-over-h2o2-production-will-increase-pb-tolerance-in-prosopis-farcta-via-altered-primary-metabolism
#17
Somaieh Zafari, Mohsen Sharifi, Luis A J Mur, Najmeh Ahmadian Chashmi
Reactive oxygen species (ROS) and nitric oxide (NO) are known in triggering defense functions to detoxify heavy metal stresses. To investigate the relevance of ROS production, Pb treatment (400µM) alone and in combination with 400µM sodium ascorbate (Asc: as H2O2 scavenger) were given to hydroponically grown Prosopis farcta seedlings over a time course of 72h. Data presented here indicate that, the low extent of H2O2 due to scavenging by ascorbate, together with high level of NO improved Pb+Asc- treated Prosopis growth...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28433592/toxicity-assessment-of-multi-walled-carbon-nanotubes-on-cucurbita-pepo-l-under-well-watered-and-water-stressed-conditions
#18
Mehrnaz Hatami
The rapid increase in the production and application of various types of nanomaterials increases the possibility of their presence in total environment, which subsequently raises concerns about their potential threats to the first trophic level of organisms, specifically under varying environmental constraints. In this work, seeds of Cucurbita pepo L. were cultured in MS basal medium exposed to multi-walled carbon nanotubes (MWCNTs) at different concentrations (0, 125, 250, 500 and 1000μgmL(-1)) under two levels of water potential, well-watered (0MPa) and water stress (-1...
April 20, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28433566/%C3%AE-aminoisobutyric-acid-ameliorates-the-renal-fibrosis-in-mouse-obstructed-kidneys-via-inhibition-of-renal-fibroblast-activation-and-fibrosis
#19
Huijuan Wang, Jun Qian, Xiufen Zhao, Changing Xing, Bin Sun
Renal fibrosis is a hallmark feature of chronic kidney disease, which is reflected by proliferation and migration of interstitial fibroblasts and extracellular matrix (ECM) accumulation. β-Aminoisobutyric acid (BAIBA) is recently demonstrated to exert a protective role from metabolic diseases. However, whether and how BAIBA on fibroblast activation and renal fibrosis response to angiotensin II (Ang II) remains largely obscure. Herein, we showed that BAIBA significantly depressed the proliferation and migration of NRK-49F cells in vitro...
February 8, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28433459/depressive-disorders-processes-leading-to-neurogeneration-and-potential-novel-treatments
#20
REVIEW
Gregory M Brown, Roger S McIntyre, Joshua Rosenblat, Rüdiger Hardeland
Mood disorders are wide spread with estimates that one in seven of the population are affected at some time in their life (Kessler et al., 2012). Many of those affected with severe depressive disorders have cognitive deficits which may progress to frank neurodegeneration. There are several peripheral markers shown by patients who have cognitive deficits that could represent causative factors and could potentially serve as guides to the prevention or even treatment of neurodegeneration. Circadian rhythm misalignment, immune dysfunction and oxidative stress and circadian rhythm misalignment are key pathologic processes implicated in neurodegeneration and cognitive dysfunction in depressive disorders...
April 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
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