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https://www.readbyqxmd.com/read/29223126/hpev-3-predominated-among-parechovirus-a-positive-infants-during-an-outbreak-in-2013-2014-in-queensland-australia
#1
Donna McNeale, Claire Y T Wang, Katherine E Arden, Ian M Mackay
BACKGROUND: Parechoviruses (HPeV) are endemic seasonal pathogens detected from the respiratory tract, gut, blood and central nervous system (CNS) of children and adults, sometimes in conjunction with a range of acute illnesses. HPeV CNS infection may lead to neurodevelopmental sequelae, especially following infection by HPeV-3, hence screening and genotyping are important to inform epidemiology, aetiology and prognosis. OBJECTIVES: To identify and characterise HPeVs circulating during an outbreak between November 2013 and April 2014 in Queensland, Australia...
December 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29222716/childhood-acute-disseminated-encephalomyelitis-an-egyptian-pilot-study
#2
Hamed Ahmed Elkhayat, Omnia Fathy El-Rashidy, Iman Ali Elagouza, Raghda Zaitoun, Yasser Abdel Azeem Abbas
Describing the variable clinical features, laboratory findings, neuroimaging findings, and treatments given to children who presented with ADEM and following them up both clinically and radiologically. 21 patients were recruited: 14 new cases, and 7 old ones presenting over the preceding 5 years (retrospective review of existing data). 11 males and 10 females, with a mean age of 4.4 years ± 2.7 SD, were included. All new patients were subject to full history, examination and a panel of investigations including MRI of the brain...
December 8, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29222552/animal-models-of-retinal-vein-occlusion
#3
Meiaad Khayat, Noemi Lois, Michael Williams, Alan W Stitt
Purpose: To provide a comprehensive and current review on the available experimental animal models of retinal vein occlusion (RVO) and to identify their strengths and limitations with the purpose of helping researchers to plan preclinical studies on RVO. Methods: A systematic review of the literature on experimental animal models of RVO was undertaken. Medline, SCOPUS, and Web of Science databases were searched. Studies published between January 1, 1965, and March 31, 2017, and that met the inclusion criteria were reviewed...
December 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29222477/a-novel-eeg-based-spectral-analysis-of-persistent-brain-function-alteration-in-athletes-with-concussion-history
#4
Tamanna T K Munia, Ali Haider, Charles Schneider, Mark Romanick, Reza Fazel-Rezai
The neurocognitive sequelae of a sport-related concussion and its management are poorly defined. Detecting deficits are vital in making a decision about the treatment plan as it can persist one year or more following a brain injury. The reliability of traditional cognitive assessment tools is debatable, and thus attention has turned to assessments based on electroencephalogram (EEG) to evaluate subtle post-concussive alterations. In this study, we calculated neurocognitive deficits combining EEG analysis with three standard post-concussive assessment tools...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221912/variable-clinical-phenotype-in-two-siblings-with-aicardi-gouti%C3%A3-res-syndrome-type-6-and-a-novel-mutation-in-the-adar-gene
#5
Lisa Schmelzer, Martin Smitka, Christine Wolf, Nadja Lucas, Victoria Tüngler, Gabriele Hahn, Andreas Tzschach, Nataliya Di Donato, Min Ae Lee-Kirsch, Maja von der Hagen
Aicardi-Goutières syndrome (AGS) is a hereditary inflammatory encephalopathy resulting in severe neurological damage in the majority of cases. We report on two siblings with AGS6 due to compound heterozygosity for a known and a novel mutation in the ADAR gene and a strikingly variable phenotype. The first sibling presented at 12 months of age with a subacute encephalopathy following a mild respiratory infection. The child developed a spastic tetraparesis, generalized dystonia and dysarthria. In contrast, the younger sibling presented with an acute episode of neurological impairment in his third year of life, from which he recovered without sequelae within a few weeks...
November 22, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29221617/minor-procedure-major-impact-patient-reported-outcomes-following-urethral-meatotomy
#6
Briony K Varda, Tanya Logvinenko, Stuart Bauer, Bartley Cilento, Richard N Yu, Caleb P Nelson
INTRODUCTION: Urethral meatotomy as treatment for meatal stenosis is a common pediatric urology procedure; however, little is known about the patient experience following this procedure. OBJECTIVE: We aim to evaluate clinical factors associated with patient-reported symptom improvement after urethral meatotomy. STUDY DESIGN: The families of boys undergoing urethral meatotomy between 2/2013 and 8/2016 received a survey by mail 6 weeks after surgery...
November 17, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29221482/rejection-acceptance-and-the-spectrum-between-understanding-male-attitudes-and-experiences-towards-conflict-related-sexual-violence-in-eastern-democratic-republic-of-congo
#7
Jocelyn Kelly, Katherine Albutt, Justin Kabanga, Kimberley Anderson, Michael VanRooyen
BACKGROUND: Female survivors of sexual violence in conflict experience not only physical and psychological sequelae from the event itself, but often many negative social outcomes, such as rejection and ostracisation from their families and community. Male relatives - whether husbands, fathers, brothers - play a key role in determining how the family and community respond to a survivor of sexual violence. Understanding these perspectives could help improve services for survivors of sexual violence, as well as their families and communities...
December 8, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/29219781/a-novel-duraplasty-technique-following-fenestration-of-a-massive-lumbar-arachnoid-cyst-in-a-patient-with-scoliosis-technical-case-report
#8
Matthew T Neal, Randall J Hlubek, Alexander E Ropper, U Kumar Kakarla
When a dural defect is encountered during spine surgery, the dura mater must be reconstituted to minimize the occurrence of minor or major life-threatening sequelae. The neurosurgical literature lacks strategies for managing large dural defects encountered during surgery. The authors describe a 24-year-old man who developed cauda equina syndrome secondary to altered CSF flow in a large thoracolumbar arachnoid cyst. Surgical decompression and fenestration of the arachnoid cyst were performed, and the large dural defect was treated using a multilayer closure with collagen matrix, titanium mesh, and methylmethacrylate...
December 8, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29218468/prediction-of-unfavorable-outcomes-in-cryptococcal-meningitis-results-of-the-multicenter-infectious-diseases-international-research-initiative-id-iri-cryptococcal-meningitis-study
#9
I N Hakyemez, H Erdem, G Beraud, M Lurdes, A Silva-Pinto, C Alexandru, B Bishop, F Mangani, X Argemi, M Poinot, R Hasbun, M Akcaer, S Alp, T Demirdal, K Angamuthu, F Amer, E Ragab, G A Shehata, D Ozturk-Engin, N Ozgunes, L Larsen, S Zimmerli, O R Sipahi, E Tukenmez Tigen, G Celebi, N Oztoprak, A C Yardimci, Y Cag
Cryptococcal meningitis (CM) is mostly seen in immunocompromised patients, particularly human immunodeficiency virus (HIV)-positive patients, but CM may also occur in apparently immunocompetent individuals. Outcome analyses have been performed in such patients but, due to the high prevalence of HIV infection worldwide, CM patients today may be admitted to hospitals with unknown HIV status, particularly in underdeveloped countries. The objective of this multicenter study was to analyze all types of CM cases in an aggregate cohort to disclose unfavorable outcomes...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29218392/unusual-circumstances-to-diagnose-cervical-pott-s-disease
#10
Mohamed Ali Kedous, Ahmed Msakni, Wael Chebbi, Mourad Zaraa, Mohsen Trabelsi
Tuberculous spondylodiscitis usually affects the dorso-lumbar spine, and its cervical location is a rare condition that can mimic other diseases and consequently cause treatment delays. We report a case of tuberculous spondylodiscitis of the lower cervical spine discovered under unusual circumstances in a patient with severe polytrauma involving a cranio-cerebral trauma, a non-displaced fracture of the two laminæ and the spinous process of the C6 vertebrae as well as fibular and tibial shaft fractures. The patient underwent static tibial nailing, and a collar with occipital and chin supports was applied...
December 7, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/29217760/tumor-associated-fatigue-in-cancer-patients-develops-independently-of-interleukin-1-signaling
#11
Aaron J Grossberg, Elisabeth G Vichaya, Diana L Christian, Jessica M Molkentine, Daniel W Vermeer, Phillip S Gross, Paola D Vermeer, John H Lee, Robert Dantzer
Fatigue is the most common symptom of cancer at diagnosis, yet causes and effective treatments remain elusive. As tumors can be highly inflammatory, it is generally accepted that inflammation mediates cancer-related fatigue. However, evidence to support this assertion is mostly correlational. In this study, we directly tested the hypothesis that fatigue results from propagation of tumor-induced inflammation to the brain and activation of the central pro-inflammatory cytokine, interleukin-1 (IL-1). The heterotopic syngeneic murine head and neck cancer model (mEER) caused systemic inflammation and increased expression of Il1b in the brain while inducing fatigue-like behaviors characterized by decreased voluntary wheel running and exploratory activity...
December 7, 2017: Cancer Research
https://www.readbyqxmd.com/read/29217514/novel-ocular-toxicity-associated-with-fibroblast-growth-factor-receptor-fgfr-inhibitors-in-cancer-treatment-observational-case-series
#12
Daniel Velazquez-Villoria, Analia Azaro, Jordi Rodon, Cinta Hierro, Danai Kyriakou, Jose Garcia-Arumi, Miguel Angel Zapata
AIMS: To describe novel ocular toxicity in patients with metastatic cancer undergoing chemotherapy with fibroblast growth factor receptor (FGFR) inhibitors. METHODS: This observational case series study included five patients with advanced cancer who received selected pan-FGFR inhibitors as single chemotherapy in the framework of a dose-finding study and phase I and phase II clinical studies. In all cases, subfoveal neurosensory retinal detachment was diagnosed...
December 7, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29217322/incidence-of-ureterovesical-obstruction-and-cohen-antireflux-surgery-after-deflux%C3%A2-treatment-for-vesicoureteric-reflux
#13
Manabu Okawada, Hiroshi Murakami, Nana Tanaka, Yuki Ogasawara, Geoffrey J Lane, Tadaharu Okazaki, Toshihiro Yanai, Masahiko Urao, Atsuyuki Yamataka
AIM: The purpose of this study was to determine the incidence of ureteric obstruction (UB) and requirement for Cohen antireflux surgery (CAS) after DefluxⓇ treatment (DT) for vesicoureteric reflux (VUR). METHODS: Between 2011 and 2017, 494 ureters (VUR severity ≤ grade III: N=291 or >grade IV: N=203) were treated by DT at a mean age of 4.5 (range: 0.2-24) years. Epidural Catheter Assistance (ECA) was used to exclude UB by injecting diluted indigo carmine solution (1-3mL) into an epidural catheter inserted into a ureter after DT and confirming dye flow within 15min...
November 14, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29217070/congenital-vascular-tumors
#14
REVIEW
Jeremy A Goss, Arin K Greene
Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. These lesions present during infancy or childhood, may affect any location, and exhibit postnatal growth. Local complications include bleeding, tissue destruction, and pain whereas systemic sequelae include thrombocytopenia, congestive heart failure, and death. Vascular tumors should be differentiated from vascular malformations, which present at birth, have a quiescent endothelium, and grow in proportion to the child. Together, vascular tumors and malformations comprise the field of vascular anomalies...
February 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29216705/-functional-results-of-open-wedge-osteotomies-in-lower-limb-angular-deformities-in-teenagers
#15
C Orellana-Reta, L A Valdez-Jiménez
OBJECTIVE: The aim of this study was to evaluate the functional and radiographic results of adolescent patients with angular deformities of the pelvic limbs treated with an open wedge osteotomy system. MATERIAL AND METHODS: Observational, prospective, analytical and cross-sectional study of patients with angular deformity of the pelvic limbs treated with an open wedge osteotomy. We made a radiographic evaluation of the femorotibial angle, MAD angle, lower limb discrepancy, and pre- and postoperative degrees of the rotational center of deformity (CORA), as well as a telephone survey of the postoperative functional evaluation IKDC 2000...
May 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29216670/-systematic-review-of-the-burden-of-campylobacter-associated-disease
#16
Julia Lackner, Daniela Schlichting, Christine Müller-Graf, Matthias Greiner
Bacteria of the genus Campylobacter spp. are one of the most common causes of gastroenteritis and can lead to serious sequelae. Several studies have estimated the disease burden of Campylobacter spp. with the quantitative metric of disability-adjusted life years (DALY). The aim of this systematic review is to give an overview of the information available about different countries and periods for which DALYs were calculated and how the different results are comparable. One of the most important transmission pathways for Campylobacter spp...
December 7, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/29216341/use-and-importance-of-nonhuman-primates-in-metabolic-disease-research-current-state-of-the-field
#17
Peter J Havel, Paul Kievit, Anthony G Comuzzie, Andrew A Bremer
Obesity and its multiple metabolic sequelae, including type 2 diabetes, cardiovascular disease, and fatty liver disease, are becoming increasingly widespread in both the developed and developing world. There is an urgent need to identify new approaches for the prevention and treatment of these costly and prevalent metabolic conditions. Accomplishing this will require the use of appropriate animal models for preclinical and translational investigations in metabolic disease research. Although studies in rodent models are often useful for target/pathway identification and testing hypotheses, there are important differences in metabolic physiology between rodents and primates, and experimental findings in rodent models have often failed to be successfully translated into new, clinically useful therapeutic modalities in humans...
December 5, 2017: ILAR Journal
https://www.readbyqxmd.com/read/29215524/urinary-tract-injury-in-gynecologic-laparoscopy-for-benign-indication-a-systematic-review
#18
Jacqueline M K Wong, Pietro Bortoletto, Jocelyn Tolentino, Michael J Jung, Magdy P Milad
OBJECTIVE: To perform a comprehensive literature review of the incidence, location, etiology, timing, management, and long-term sequelae of urinary tract injury in gynecologic laparoscopy for benign indication. DATA SOURCES: A systematic review of PubMed, EMBASE, Cochrane Library, and ClinicalTrials.gov was conducted. METHODS OF STUDY SELECTION: Four hundred thirty-three studies were screened for inclusion with 136 full-text articles reviewed...
December 4, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29215444/mandibular-reconstruction-by-osteogenic-distraction-due-to-two-different-injuries
#19
Guilherme Dos Santos Trento, José Maurício Dos Santos Nunes Reis, Eduardo Hochuli-Vieira, Valfrido Antônio Pereira-Filho
Varied factors, whether intrinsic or extrinsic, may lead to a decrease in the bone volume of the jaws. Trauma and pathology can be listed as examples of such factors. The aim of this study is to present the osteogenic distraction technique as alternative to augmentation of low mandibular bone volume caused by different etiologies. The first case reports a mandibular marginal resection of ameloblastoma and the second one reports a male patient presenting mandibular fracture sequelae. Both cases were treated according to the osteogenic distraction technique...
December 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29215438/mucosal-dehiscence-after-alveolar-bone-graft-in-cleft
#20
Giulia Amodeo, Domenico Scopelliti
Cleft lip and palate patient represent a challenging experience for the surgeon. This kind of patients had to be followed by a multidisciplinary team from the beginning to the end to avoid the deformation sequelae. During the several surgical procedures, the bone graft represents a possible procedure that, through the new procedure, could be avoided. Unfortunately, patient treated following the previous procedure must be submitted to alveolar bone graft to coordinate the arch, to restore the maxillary integrity, to allow the correct dentition...
December 6, 2017: Journal of Craniofacial Surgery
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