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https://www.readbyqxmd.com/read/29469225/successful-hematopoietic-stem-cell-transplantation-for-osteopetrosis-using-reduced-intensity-conditioning
#1
Bella Shadur, Irina Zaidman, Adeeb NaserEddin, Elana Lokshin, Fatma Hussein, Hodaya Cohen Oron, Batia Avni, Sigal Grisariu, Polina Stepensky
BACKGROUND: Infantile malignant osteopetrosis (IMO) is an autosomal recessive condition characterized by defective osteoclast activity, with hematopoietic bone marrow transplant being the only available cure. Over the past several years, new conditioning regimes and donor options have emerged, thus extending the possibility of cure to a greater number of patients and improving the outcomes of bone marrow transplant. Here we detail the outcomes of bone marrow transplant in a cohort of 31 patients treated with a combination of fludarabine, treosulphan, thiotepa, and antithymocyte globulin...
February 22, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29468596/an-in-vitro-oxygen-glucose-deprivation-model-for-studying-ischemia-reperfusion-injury-of-neuronal-cells
#2
Myoung-Gwi Ryou, Robert T Mallet
Ischemia-reperfusion syndromes of the heart and brain are the leading cause of death and long-term disability worldwide. Development of effective treatments for myocardial infarction, stroke, cardiac arrest and their sequelae requires preclinical models that replicate specific features of ischemia-reperfusion. The complexities of intact animals, including the integrated function of organ systems, autonomic innervation and endocrine factors, often preclude detailed study of specific components of ischemia-reperfusion injury cascades...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29468203/inner-retinal-vasculopathy-in-zika-virus-disease
#3
Mandeep S Singh, Maria Carolina Marquezan, Revaz Omiadze, Ashvini K Reddy, Rubens Belfort, William N May
Purpose: Zika virus infection is associated with vision-threatening ocular complications including uveitis and outer retinopathy. The aim of this report is to describe a case of an adult patient with serologically confirmed Zika infection who presented with retinal vascular abnormalities that coincided with systemic post-viral neurological manifestations of the disease. Observations: A 34-year-old white female presented with symptoms of peripheral neuropathy following serologically confirmed Zika virus infection that was acquired in Puerto Rico four months prior to presentation...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29468169/severe-human-granulocytic-anaplasmosis-with-significantly-elevated-ferritin-levels-in-an-immunocompetent-host-in-pennsylvania-a-case-report
#4
Mona L Camacci, Ronaldo Paolo Panganiban, Zachary Pattison, Kamyar Haghayeghi, Alexander Daly, Cindy Ojevwe, Ryan J Munyon
Human granulocytic anaplasmosis (HGA) is a tick-borne, infectious disease caused by Anaplasma phagocytophilum that generally presents with nonspecific symptoms such as fever, chills, headache, malaise, and myalgia. If not treated immediately, HGA can cause hemophagocytic lymphohistiocytosis (HLH), a well-documented but underrecognized sequela of severe HGA. In this article, we report a case of severe HGA with hyperferritinemia in a 74-year-old male from Central Pennsylvania who initially presented with recurrent fevers, nausea, and malaise to our emergency department and was subsequently discharged home that same day...
January 2018: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29468067/pharyngeal-dysphagia-due-to-varicella-zoster-virus-meningoradiculitis-and-full-recovery-case-report-and-endoscopic-findings
#5
Paul Muhle, Sonja Suntrup-Krueger, Rainer Dziewas, Tobias Warnecke
Varicella zoster virus reactivation is a rare cause of pharyngeal dysphagia with long-term sequelae persisting in most cases. A 76-year-old immunocompetent woman presented with a 4-week history of dysphagia and dysphonia. Brain magnetic resonance imaging displayed a negative finding. Fiberoptic endoscopic evaluation of swallowing showed a severe dysphagia leading to a percutaneous gastrostomy eventually. Cerebrospinal fluid analysis revealed a lymphocytic pleocytosis and polymerase chain reaction amplified Varicella zoster virus DNA...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/29467816/advanced-gallbladder-inflammation-is-a-risk-factor-for-gallbladder-perforation-in-patients-with-acute-cholecystitis
#6
Stefan Jansen, Maciej Stodolski, Hubert Zirngibl, Daniel Gödde, Peter C Ambe
Background: Acute perforated cholecystitis (APC) is probably the most severe benign gallbladder pathology with high rates of morbidity and mortality. The cause of APC has not been fully understood. We postulated that APC is a complication of advanced gallbladder inflammation. The aim of this study was to investigate the extent of gallbladder inflammation in patients with APC. Methods: Patients with intraoperative and histopathologic diagnosis of APC were compared with cases with acute cholecystitis without perforation with respect to the extent of inflammation on histopathology as well as surgical outcomes...
2018: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/29467621/immunosignals-of-oligodendrocyte-markers-and-myelin-associated-proteins-are-critically-affected-after-experimental-stroke-in-wild-type-and-alzheimer-modeling-mice-of-different-ages
#7
Dominik Michalski, Anna L Keck, Jens Grosche, Henrik Martens, Wolfgang Härtig
Because stroke therapies are still limited and patients are often concerned by long-term sequelae with significant impairment of daily living, elaborated neuroprotective strategies are needed. During the last decades, research substantially improved the knowledge on cellular pathologies responsible for stroke-related tissue damage. In this context, the neurovascular unit (NVU) concept has been established, summarizing the affections of neurons, associated astrocytes and the vasculature. Although oligodendrocytes were already identified to play a major role in other brain pathologies, their role during stroke evolution and long-lasting tissue damage is poorly understood...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29466409/il-7-treatment-augments-and-prolongs-sepsis-induced-expansion-of-il-10-producing-b-lymphocytes-and-myeloid-derived-suppressor-cells
#8
Upasana Kulkarni, Christoph Herrmenau, Stephanie J Win, Michael Bauer, Thomas Kamradt
Immunological dysregulation in sepsis is associated with often lethal secondary infections. Loss of effector cells and an expansion of immunoregulatory cell populations both contribute to sepsis-induced immunosuppression. The extent and duration of this immunosuppression are unknown. Interleukin 7 (IL-7) is important for the maintenance of lymphocytes and can accelerate the reconstitution of effector lymphocytes in sepsis. How IL-7 influences immunosuppressive cell populations is unknown. We have used the mouse model of peritoneal contamination and infection (PCI) to investigate the expansion of immunoregulatory cells as long-term sequelae of sepsis with or without IL-7 treatment...
2018: PloS One
https://www.readbyqxmd.com/read/29466380/q-fever-in-egypt-epidemiological-survey-of-coxiella-burnetii-specific-antibodies-in-cattle-buffaloes-sheep-goats-and-camels
#9
Jessica Klemmer, John Njeru, Aya Emam, Ahmed El-Sayed, Amira A Moawad, Klaus Henning, Mohamed A Elbeskawy, Carola Sauter-Louis, Reinhard K Straubinger, Heinrich Neubauer, Mohamed M El-Diasty
Q fever is a zoonotic disease caused by the bacterium Coxiella burnetii. Clinical presentation in humans varies from asymptomatic to flu-like illness and severe sequelae may be seen. Ruminants are often sub-clinically infected or show reproductive disorders such as abortions. In Egypt, only limited data on the epidemiology of Q fever in animals are available. Using a stratified two stage random sampling approach, we evaluated the prevalence of Coxiella burnetii specific antibodies among ruminants and camels in 299 herds...
2018: PloS One
https://www.readbyqxmd.com/read/29465954/sexual-and-vegetative-propagation-of-the-medicinal-mexican-species-phyllonoma-laticuspis-phyllonomaceae
#10
Ela Alcántara-Flores, Alicia E Brechú-Franco, Angel Villegas-Monter, Guillermo Laguna-Hernández, Armando Gómez-Campos
Phyllonoma laticuspis leaves are used in Carrizal de Bravo, Guerrero, Mexico, to heal skin lesions such as injuries and smallpox sequelae and to treat diabetes mellitus type 2, and organic extracts of these leaves have been reported to exert antibacterial effects. High demand of P. laticuspis as a medicinal plant has decreased its natural populations, and propagation of the species has not yet been reported. Therefore, the purpose of this study was to assess the vegetative propagation of the species through cutting and air layering, as well as its sexual propagation in a preserved population...
March 2017: Revista de Biología Tropical
https://www.readbyqxmd.com/read/29463943/tarsal-tunnel-syndrome-caused-by-a-schwannoma-of-the-posterior-tibial-nerve
#11
Kenya Watanabe, Takuma Fukuzawa, Katsuhiro Mitsui
Schwannoma is the most common tumor of the peripheral nerve sheath. However, there have been few reports on schwannoma of the posterior tibial nerve causing tarsal tunnel syndrome. We report on a 60-year-old man with tarsal tunnel syndrome caused by a schwannoma of the posterior tibial nerve, which was first diagnosed as a ganglion cyst. After enucleation of this tumor, the patient was asymptomatic and had no related sequelae except for minor numbness in the plantar aspects of his digits. Although schwannoma of the posterior tibial nerve is rare, it should be considered even if a ganglion is clinically suspected...
February 2018: Acta Medica Okayama
https://www.readbyqxmd.com/read/29463864/lateral-tarsal-strip-versus-bick-s-procedure-in-correction-of-eyelid-malposition
#12
Kaveh Vahdani, Rebecca Ford, Helen Garrott, Vladimir Theodor Thaller
OBJECTIVES: To compare the functional and anatomical outcomes of lateral tarsal strip (LTS) with Bick's procedure in treatment of eyelid malposition. METHODS: A retrospective, consecutive case series of patients who underwent LTS and Bick's procedure for all types of involutional lower eyelid malposition, at two centers between January 2012 and 2015. Statistical analyses of differences between groups were performed using the Fisher's exact test to compare non-continuous variables and Mann-Whitney U test for continuous variables...
February 21, 2018: Eye
https://www.readbyqxmd.com/read/29463135/investigating-a-theatre-based-intervention-for-indigenous-youth-with-fetal-alcohol-spectrum-disorder-exploration-d-une-intervention-bas%C3%A3-e-sur-le-th%C3%A3-%C3%A3-tre-aupr%C3%A3-s-de-jeunes-autochtones-atteints-du-syndrome-d-alcoolisme-f%C3%A5-tal
#13
Michelle Keightley, Sabrina Agnihotri, Sivaniya Subramaniapillai, Julia Gray, Jennifer Keresztesi, Angela Colantonio, Helene J Polatajko, Debra Cameron, Catherine Wiseman-Hakes
BACKGROUND: Theatre-based interventions use artistic media to facilitate social and emotional awareness and have therapeutic benefits for persons with developmental disabilities and mental health problems. The role of these interventions with Indigenous youth who have emotional, behavioural, and cognitive sequelae related to fetal alcohol spectrum disorder (FASD) has not been explored. PURPOSE: The purpose of this study was to explore the experiences and acceptability of a theatre-based approach for facilitating social communication and engagement in youth with FASD...
January 1, 2018: Canadian Journal of Occupational Therapy. Revue Canadienne D'ergothérapie
https://www.readbyqxmd.com/read/29463113/pediatric-lip-adhesion-following-bullous-erythema-multiforme-and-review-of-similar-oral-complications
#14
Rosalind Ashton, Karen W Wong, Miriam Weinstein
BACKGROUND: Erythema multiforme (EM) is a mucocutaneous disease most often associated with preceding herpes simplex virus or Mycoplasma pneumoniae infection. It is characterized by targetoid lesions occurring on the limbs and head and neck. Mucosal involvement can be extensive. OBJECTIVE: We report a case of lip adhesion as a complication of EM in a child who required corrective surgery and review similar oral commissure complications. METHODS: We completed a review of the literature for similar cases using PubMed and Medline...
February 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29462223/efficacy-safety-and-tolerability-of-topical-dapsone-gel-7-5-for-treatment-of-acne-vulgaris-by-fitzpatrick-skin-phototype
#15
Susan C Taylor, Fran E Cook-Bolden, Amy McMichael, Jeanine B Downie, David A Rodriguez, Andrew F Alexis, Valerie D Callender, Nancy Alvandi
BACKGROUND: Acne vulgaris (acne) is prevalent in individuals with skin of color, often with more frequent sequelae than in patients with lighter skin color. It is important to determine if there are also differences in response to medications. OBJECTIVE: This study evaluated the efficacy and tolerability of once-daily dapsone gel, 7.5% in patients with acne, stratified by Fitzpatrick skin phototype. METHODS: Data were pooled from 2 identically designed, phase 3, randomized, double-blind, vehicle-controlled studies in patients aged 12 years and older with moderate acne...
February 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29461288/carbon-monoxide-and-cyanide-poisoning-in-the-burned-pregnant-patient-an-indication-for-hyperbaric-oxygen-therapy
#16
Derek M Culnan, Beretta Craft-Coffman, Genevieve H Bitz, Karel D Capek, Yiji Tu, William C Lineaweaver, Maggie J Kuhlmann-Capek
Carbon monoxide (CO) is a small molecule poison released as a product of incomplete combustion. Carbon monoxide binds hemoglobin, reducing oxygen delivery. This effect is exacerbated in the burned pregnant patient by fetal hemoglobin that binds CO 2.5- to 3-fold stronger than maternal hemoglobin. With no signature clinical symptom, diagnosis depends on patient injury history, elevated carboxyhemoglobin levels, and alterations in mental status. The standard of care for treatment of CO intoxication is 100% normobaric oxygen, which decreases the half-life of CO in the bloodstream from 5 hours to 1 hour...
February 15, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29461124/improving-mandibular-contour-a-pilot-study-for-indication-of-ppla-traction-thread-use
#17
Stefania Guida, Flavia Persechino, Giuseppe Rubino, Giovanni Pellacani, Francesca Farnetani, Giacomo Giovanni Urtis
BACKGROUND: The request for less-aggressive procedures to improve mandibular contour is increasing. Several kinds of threads have been used for this purpose. Nevertheless, PLLA (poly-L-Lactic acid) traction thread procedure has not been previously described. AIM: To investigate the role of PLLA traction threads in improving mandibular contour. METHODS: Twenty women were enrolled in the study. They were differentially classified for skin laxity...
February 20, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29459944/association-of-changes-in-plasma-neurofilament-light-and-tau-levels-with-anesthesia-and-surgery-results-from-the-capacity-and-arcadian-studies
#18
Lisbeth Evered, Brendan Silbert, David A Scott, Henrik Zetterberg, Kaj Blennow
Importance: Anesthesia and surgery are believed to act on the central nervous system by a fully reversible mechanism innocuous to nerve cells. Evidence that neurological sequelae may follow would challenge this belief and would thereby suggest a need to reassess theories of the mechanism of anesthetic action or the response of the central nervous system to surgery. Objective: To measure 2 biomarkers of neurological injury (neurofilament light and tau) in plasma in a series of timed collections before and after anesthesia and surgery...
February 19, 2018: JAMA Neurology
https://www.readbyqxmd.com/read/29459900/kr%C3%A3-ppel-like-factors-in-vascular-inflammation-mechanistic-insights-and-therapeutic-potential
#19
REVIEW
David R Sweet, Liyan Fan, Paishiun N Hsieh, Mukesh K Jain
The role of inflammation in vascular disease is well recognized, involving dysregulation of both circulating immune cells as well as the cells of the vessel wall itself. Unrestrained vascular inflammation leads to pathological remodeling that eventually contributes to atherothrombotic disease and its associated sequelae (e.g., myocardial/cerebral infarction, embolism, and critical limb ischemia). Signaling events during vascular inflammation orchestrate widespread transcriptional programs that affect the functions of vascular and circulating inflammatory cells...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29458937/chinese-herbal-medicine-dengzhan-shengmai-capsule-as-adjunctive-treatment-for-ischemic-stroke-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#20
REVIEW
Xiao-Ying Yang, Li-Qiong Wang, Jin-Gen Li, Ning Liang, Ying Wang, Jian-Ping Liu
OBJECTIVE: The existing eligible randomized controlled trials (RCTs) were critically appraised for the effectiveness and safety of Chinese herbal medicine Dengzhan Shenmai for ischemic stroke. DESIGN: Systematic review and meta-analysis (CRD42016042914, http://www.crd.york.ac.uk/PROSPERO). METHODS: Six electronic databases were searched from inception to May 2016. Risk ratio (RR) and mean difference (MD) with a 95% confidence interval (CI) were used as effect estimates using RevMan 5...
February 2018: Complementary Therapies in Medicine
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