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https://www.readbyqxmd.com/read/28719516/echocardiography-and-passive-leg-raising-in-the-postoperative-period-a-prospective-observational-study
#1
Yasser El Hadouti, Lucía Valencia, Angel Becerra, Aurelio Rodríguez-Pérez, Jean L Vincent
BACKGROUND: Signs of hypovolaemia are frequent in the postoperative period, but not all patients need or respond to fluid administration. An increase in cardiac output (CO) after passive leg raising (PLR) has been demonstrated to be useful as a volume response predictor in non-surgical, spontaneously breathing patients. OBJECTIVE: The objective of this study was to evaluate the accuracy of transthoracic echocardiography after PLR to predict fluid responsiveness in post-surgical patients...
July 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28719495/late-onset-hiv-encephalopathy-in-children-with-long-standing-virologic-suppression-followed-by-slow-spontaneous-recovery-despite-no-change-in-antiretroviral-therapy-four-case-reports
#2
Steve Innes, Ronald van Toorn, Kennedy Otwombe, Els Dobbels, Gert van Zyl, Mark F Cotton, Barbara Laughton
We describe four CHER (Children with HIV Early antiRetroviral therapy) trial participants with late-onset HIV encephalopathy despite long-standing viral suppression in blood and undetectable HIV DNA and RNA PCR in cerebrospinal fluid. Extensive investigations revealed no alternative etiology. Reassuringly, all four experienced slow spontaneous recovery despite no change in antiretroviral therapy. Virally-suppressed HIV-infected children remain at risk for fluctuating neurologic signs and symptoms.
July 15, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28719397/obesity-and-pancreatitis
#3
Biswajit Khatua, Bara El-Kurdi, Vijay P Singh
PURPOSE OF REVIEW: The obesity pandemic poses a unique set of problems for acute pancreatitis - both by increasing acute pancreatitis incidence, and worsening acute pancreatitis severity. This review explores these associations, underlying mechanisms, and potential therapies. RECENT FINDINGS: We review how the obesity associated increase in gallstones, surgical, and endoscopic interventions for obesity management, diabetes, and related medications such as incretin-based therapies and hypertriglyceridemia may increase the incidence of acute pancreatitis...
July 17, 2017: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/28717907/elevated-lactate-is-independently-associated-with-adverse-outcomes-following-hepatectomy
#4
Madeline Lemke, Paul J Karanicolas, Rogeh Habashi, Ramy Behman, Natalie G Coburn, Sherif S Hanna, Calvin H L Law, Julie Hallet
BACKGROUND: Arterial lactate is frequently monitored to indicate tissue hypoxia and direct therapy. We sought to determine whether early post-hepatectomy lactate (PHL) is associated with adverse outcomes and define factors associated with PHL. METHODS: Hepatectomy patients at a single institution from 2003 to 2012 with PHL available were included. Univariable and multivariable analyses examined factors associated with PHL and the relationship between PHL and 30-day major morbidity (Clavien grade III-V), 90-day mortality, and length of stay (LOS)...
July 17, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28717640/lung-microbiome-and-host-immune-tone-in-subjects-with-idiopathic-pulmonary-fibrosis-treated-with-inhaled-interferon-%C3%AE
#5
Jing Wang, Melissa Lesko, Michelle H Badri, Bianca C Kapoor, Benjamin G Wu, Yonghua Li, Gerald C Smaldone, Richard Bonneau, Zachary D Kurtz, Rany Condos, Leopoldo N Segal
Therapies targeting inflammation reveal inconsistent results in idiopathic pulmonary fibrosis (IPF). Aerosolised interferon (IFN)-γ has been proposed as a novel therapy. Changes in the host airway microbiome are associated with the inflammatory milieu and may be associated with disease progression. Here, we evaluate whether treatment with aerosolised IFN-γ in IPF impacts either the lower airway microbiome or the host immune phenotype. Patients with IPF who enrolled in an aerosolised IFN-γ trial underwent bronchoscopy at baseline and after 6 months...
July 2017: ERJ Open Research
https://www.readbyqxmd.com/read/28714751/antidepressant-efficacy-of-electroconvulsive-therapy-is-associated-with-a-reduction-of-the-innate-cellular-immune-activity-in-the-cerebrospinal-fluid-in-patients-with-depression
#6
Laura Kranaster, Carolin Hoyer, Suna S Aksay, J Malte Bumb, Norbert Müller, Peter Zill, Markus J Schwarz, Alexander Sartorius
OBJECTIVES: A bidirectional link between the antidepressant effects of electroconvulsive therapy (ECT) and the modulation of the immune system has been proposed. To elucidate the interplay between antidepressant treatment and macrophage/microglia activation in humans, we performed a study on the effects of the antidepressant treatment by ECT on markers of macrophage/microglia activation in patients with depression. METHODS: We measured six different markers (IL-6, neopterin, sCD14, sCD163 MIF and MCP1) of macrophage/microglia activation in the cerebrospinal fluid (CSF) and blood of 12 patients with a severe, treatment-resistant depressive episode before and after a course of ECT...
July 17, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28713271/luminally-acting-agents-for-constipation-treatment-a-review-based-on-literatures-and-patents
#7
REVIEW
Hong Yang, Tonghui Ma
Constipation is one of the most frequently reported gastrointestinal (GI) disorders that negatively impacts quality of life and is associated with a significant economic burden to the patients and society. Traditional treatments including lifestyle modification and laxatives are often ineffective in the more severe forms of constipation and over the long term. New medications targeting at intestinal chloride channels and colonic serotonin receptors have been demonstrated effective in recent years. Emerging agents focusing on improving intestinal secretion and/or colonic motility have been shown effective in animal models and even in clinical trials...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28713067/eus-guided-drainage-of-peripancreatic-fluid-collections-with-lumen-apposing-metal-stents-and-plastic-double-pigtail-stents-comparison-of-efficacy-and-adverse-event-rates
#8
Gabriel D Lang, Cassandra Fritz, Trisha Bhat, Koushik K Das, Faris M Murad, Dayna S Early, Steven A Edmundowicz, Vladimir M Kushnir, Daniel K Mullady
BACKGROUND AND AIMS: Transmural drainage with double-pigtail plastic stents (DPPSs) was the mainstay of endoscopic therapy for symptomatic peri-pancreatic fluid collections (PPFCs) until the introduction of lumen-apposing covered self-expanding metal stents (LAMSs). Currently, there is limited data regarding the efficacy and adverse event rate of LAMS compared with DPPS. METHODS: A retrospective analysis of EUS-guided PPFC drainages at a single tertiary care center between 2008 and 2015 was performed...
July 13, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28711538/cerebral-venous-sinus-thrombosis-secondary-to-idiopathic-hypertrophic-cranial-pachymeningitis-a-case-report-and-review-of-the-literature
#9
Kaiyuan Huang, Qingsheng Xu, Yuankun Ma, Renya Zhan, Jian Shen, Jianwei Pan
BACKGOUND AND IMPORTANCE: Idiopathic hypertrophic cranial pachymeningitis (IHCP) is a rare fibrosing inflammatory process involving the dura mater. Currently, there is no consensus on the treatments for IHCP, and the usefulness of immunosuppressive agents as a first-line option remains controversial. Cerebral venous sinus occlusion (CVSO) and cerebral venous sinus thrombosis (CVST) secondary to IHCP, which may cause progressive intracranial hypertension and venous obstructive parenchymal lesions, make the diagnosis and treatment of IHCP more complicated...
July 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28709951/microrna-basic-concepts-and-implications-for-regeneration-and-repair-of-neurodegenerative-diseases
#10
REVIEW
Cláudia Saraiva, Marta Esteves, Liliana Bernardino
MicroRNAs (miRNA) are small non-coding molecules that revolutionized our knowledge about the regulation of gene expression. Capable to target a large number of mRNA, miRNA are thought to regulate around 30% of the entire human genome. Therefore, these molecules are able to regulate several biological processes, including neuronal survival, differentiation and regeneration. Additionally, miRNA might act as valuable clinical agents in brain pathological conditions: their specific expression patterns in the brain parenchyma and/or in circulating fluids have been highlighted as potential biomarkers while the modulation of their activity may have therapeutic value for several neurodegenerative diseases...
July 11, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28709478/erratum-to-fluid-therapy-recommendations-for-major-abdominal-surgery-via-rica-recommendations-revisited-part-iii-goal-directed-hemodynamic-therapy-rationale-for-maintaining-vascular-tone-and-contractility-rev-esp-anestesiol-reanim-2017-64-6-348-359
#11
J Ripollés-Melchor, D Chappell, H D Aya, Á Espinosa, M G Mythen, A Abad-Gurumeta, S D Bergese, R Casans-Francés, J M Calvo-Vecino
No abstract text is available yet for this article.
August 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28709477/erratum-to-fluid-therapy-recommendations-for-major-abdominal-surgery-via-rica-recommendations-revisited-part-ii-goal-directed-hemodynamic-therapy-rationale-for-optimising-intravascular-volume-rev-esp-anestesiol-reanim-2017-64-6-339-347
#12
J Ripollés-Melchor, D Chappell, H D Aya, Á Espinosa, M G Mythen, A Abad-Gurumeta, S D Bergese, R Casans-Francés, J M Calvo-Vecino
No abstract text is available yet for this article.
August 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28709476/erratum-to-perioperative-fluid-therapy-recommendations-for-major-abdominal-surgery-via-rica-recommendations-revisited-part-i-physiological-background-rev-esp-anestesiol-reanim-2017-64-6-328-338
#13
J Ripollés-Melchor, D Chappell, Á Espinosa, M G Mythen, A Abad-Gurumeta, S D Bergese, R Casans-Francés, J M Calvo-Vecino
No abstract text is available yet for this article.
August 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28709170/-leptomeningeal-carcinomatosis-as-a-rare-metastatic-spreading-of-braf-mutated-microsatellite-stable-colon%C3%A2-cancer
#14
Aksana Höblinger, Stephanie Weber, Florian Tschirner, Stefan Kröber, Konrad Streetz
Leptomeningeal carcinomatosis is a rare but serious complication of solid tumors such as melanoma, breast and lung cancer, as well as gastrointestinal carcinomas. Its clinical manifestation is highly variable, presenting as radicular pain with or without neurological deficits, as well as with headaches and hallucinatory irritation symptoms. Leptomeningeal carcinomatosis is often misdiagnosed, which delays treatment. Here we report a rare case of a patient with BRAF-mutated microsatellite stable colon carcinoma with lymphatic and skeletal metastases, who developed neurological symptoms one month after the initial diagnosis of malignancy...
July 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/28705153/a-randomized-clinical-pharmacokinetic-trial-of-tenofovir-in-blood-plasma-and-urine-in-adults-with-perfect-moderate-and-low-prep-adherence-the-target-study
#15
Tim R Cressey, Oraphan Siriprakaisil, Virat Klinbuayaem, Justice Quame-Amaglo, Rachel W Kubiak, Pra-Ornsuda Sukrakanchana, Kanchana Than-In-At, Jared Baeten, Wasna Sirirungsi, Ratchada Cressey, Paul K Drain
BACKGROUND: Tenofovir disoproxil fumarate (TDF) is key component of pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) for HIV, but existing tools to monitor drug adherence are often inaccurate. Detection of tenofovir (TFV) in accessible biological samples, such as fingerprick blood, urine or oral fluid samples could be a novel objective measure of recent TDF adherence. To measure TFV concentrations associated with different levels of TDF adherence, we designed a randomized clinical trial to assess the blood, urine and oral fluid concentrations of TFV in adults with perfect, moderate and low drug adherence...
July 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28701841/continuous-renal-replacement-therapy-applications-on-extracorporeal-membrane-oxygenation-circuit
#16
Ayse Filiz Yetimakman, Murat Tanyildiz, Selman Kesici, Esra Kockuzu, Benan Bayrakci
BACKGROUND AND AIMS: Continuous venovenous hemofiltration or hemodiafiltration is used frequently in pediatric patients, but experience of continuous renal replacement therapy (CRRT) application on extracorporeal membrane oxygenation (ECMO) circuit is still limited. Among several methods used for applying CRRT on ECMO patients, we aim to share our experience on inclusion of a CRRT device in the ECMO circuit which we believe is easier and safer to apply. MATERIALS AND METHODS: The data were collected on demographics, outcomes, and details of the treatment of ECMO patients who had CRRT...
June 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28701807/natriuretic-peptides-as-biomarkers-for-congestive-states-the-cardiorenal-divergence
#17
REVIEW
Abhilash Koratala, Amir Kazory
Congestion represents the primary reason for hospitalization of patients with heart failure and is associated with adverse outcomes. Fluid overload has been shown to be inadequately addressed in a significant subset of these patients in part due to lack of robust, reliable, and readily available biomarkers for objective assessment and monitoring of therapy. Natriuretic peptides have long been used in this setting, often in conjunction with other assessment tools such as imaging studies. Patients presenting with concomitant cardiac and renal dysfunction represent a unique population with regard to congestion in that the interactions between the heart and the kidney can affect the utility and performance of biomarkers of fluid overload...
2017: Disease Markers
https://www.readbyqxmd.com/read/28701191/blood-brain-barrier-and-foetal-onset-hydrocephalus-with-a-view-on-potential-novel-treatments-beyond-managing-csf-flow
#18
REVIEW
M Guerra, J L Blázquez, E M Rodríguez
Despite decades of research, no compelling non-surgical therapies have been developed for foetal hydrocephalus. So far, most efforts have pointed to repairing disturbances in the cerebrospinal fluid (CSF) flow and to avoid further brain damage. There are no reports trying to prevent or diminish abnormalities in brain development which are inseparably associated with hydrocephalus. A key problem in the treatment of hydrocephalus is the blood-brain barrier that restricts the access to the brain for therapeutic compounds or systemically grafted cells...
July 13, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/28700992/natural-history-of-fetal-lower-urinary-tract-obstruction-with-normal-amniotic-fluid-volume-at-initial-diagnosis
#19
Mark P Johnson, Enrico Danzer, Jamie Koh, William Polzin, Chris Harman, Richard O'Shaughnessy, Richard Brown, Michael V Zaretsky
OBJECTIVE: The aim of this study was to define the natural history of lower urinary tract obstruction (LUTO) with normal midgestational amniotic fluid volumes. MATERIALS AND METHODS: We performed a retrospective review of 32 consecutive patients with LUTO with normal midgestational amniotic fluid volume followed at 11 North American Fetal Therapy Network (NAFTNet) centers from August 2007 to May 2012. Normal amniotic fluid volume was defined as an amniotic fluid index (AFI) of ≥9 cm...
July 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28700464/cryptococcal-meningitis-after-transnasal-transsphenoidal-pituitary-microsurgery-of-acth-secreting-pituitary-adenoma-a-case-report
#20
Yang Liu, Ming Feng, Yong Yao, Kan Deng, Xinjie Bao, Xiaohai Liu, Renzhi Wang
RATIONALE: Microbial infection should be regarded in the differential diagnosis of neurosurgical complications after transnasal transsphenoidal pituitary microsurgery, albeit cryptococcal meningitis is rare. This article will discuss the risk factors of cryptococcal meningitis in patients underwent transnasal transsphenoidal pituitary microsurgery, and summary the potential origins of infection. PATIENT CONCERNS AND DIAGNOSIS: Here, we report a case of 37-year-old male who had cryptococcal meningitis after transnasal transsphenoidal pituitary microsurgery of a relapsing ACTH-secreting pituitary adenoma...
July 2017: Medicine (Baltimore)
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