keyword
https://read.qxmd.com/read/38635593/gallbladder-cancer-surgical-treatment-immunotherapy-and-targeted-therapy
#21
REVIEW
Yanjun Sun, Junfeng Gong, Zhuang Li, Lin Han, Dengqun Sun
Gallbladder cancer is a common type of biliary tract tumor. Optimal management for early stage cases typically involves radical excision as the primary treatment modality. Various surgical techniques, including laparoscopic, robotic, and navigational surgery, have demonstrated favorable clinical outcomes in radical gallbladder excision. Unfortunately, most patients are ineligible for surgical intervention because of the advanced stage of the disease upon diagnosis. Consequently, non-surgical interventions, such as chemotherapy, radiotherapy, immunotherapy, and targeted therapy, have become the mainstay of treatment for patients in advanced stages...
April 18, 2024: Postgraduate Medicine
https://read.qxmd.com/read/38634954/international-consensus-on-the-management-of-metastatic-gastric-cancer-step-by-step-in-the-foggy-landscape-bertinoro-workshop-november-2022
#22
JOURNAL ARTICLE
Paolo Morgagni, Maria Bencivenga, Fatima Carneiro, Stefano Cascinu, Sarah Derks, Maria Di Bartolomeo, Claire Donohoe, Clarisse Eveno, Suzanne Gisbertz, Peter Grimminger, Ines Gockel, Heike Grabsh, Paulo Kassab, Rupert Langer, Sara Lonardi, Marco Maltoni, Sheraz Markar, Markus Moehler, Daniele Marrelli, Maria Antonietta Mazzei, Davide Melisi, Carlo Milandri, Paul Stefan Moenig, Bianca Mostert, Gianni Mura, Wojciech Polkowski, John Reynolds, Luca Saragoni, Mark I Van Berge Henegouwen, Richard Van Hillegersberg, Michael Vieth, Giuseppe Verlato, Lorena Torroni, Bas Wijnhoven, Guido Alberto Massimo Tiberio, Han-Kwang Yang, Franco Roviello, Giovanni de Manzoni
BACKGROUND: Many gastric cancer patients in Western countries are diagnosed as metastatic with a median overall survival of less than twelve months using standard chemotherapy. Innovative treatments, like targeted therapy or immunotherapy, have recently proved to ameliorate prognosis, but a general agreement on managing oligometastatic disease has yet to be achieved. An international multi-disciplinary workshop was held in Bertinoro, Italy, in November 2022 to verify whether achieving a consensus on at least some topics was possible...
April 18, 2024: Gastric Cancer
https://read.qxmd.com/read/38633602/microbiota-dynamics-preceding-bariatric-surgery-as-obesity-treatment-a-comprehensive-review
#23
REVIEW
Ana Karina Zambrano, Elius Paz-Cruz, Viviana A Ruiz-Pozo, Santiago Cadena-Ullauri, Rafael Tamayo-Trujillo, Patricia Guevara-Ramírez, Raynier Zambrano-Villacres, Daniel Simancas-Racines
The review present data on the intricate relationship between bariatric surgery, gut microbiota, and metabolic health in obesity treatment. Bariatric surgery, is recognized as an effective intervention for managing morbid obesity, including various techniques with distinct mechanisms of action, efficacy, and safety profiles including Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Laparoscopic Adjustable Gastric Banding (LAGB), and Biliopancreatic Diversion (BPD). RYGB and SG are the most prevalent procedures globally, inducing gut microbiota changes that influence microbial diversity and abundance...
2024: Frontiers in Nutrition
https://read.qxmd.com/read/38633288/incidentally-detected-gallbladder-carcinoma-can-f-18-fdg-pet-ct-aid-in-staging-and-prognostication
#24
JOURNAL ARTICLE
Venkata Subramanian Krishnaraju, Rajender Kumar, Bhagwant Rai Mittal, Harjeet Singh, Piyush Aggarwal, Harmandeep Singh, Thakur Deen Yadav, Ritambhra Nada, Vikas Gupta, Rajesh Gupta
PURPOSE: Incidental gallbladder carcinoma (IGBC) is diagnosed in post-cholecystectomy specimens for benign indications, where the role of 2-fluro-2-deoxyglucose positron emission tomography/computed tomography(FDG-PET/CT) is not clearly defined. The present study aimed to assess the benefits of staging and prognosticating with FDG-PET/CT in IGBC. MATERIALS AND METHODS: A retrospective observational study from a tertiary-care center from January 2010 to July 2020 was performed...
May 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38630430/comparison-of-peritoneal-interposition-flaps-and-sealants-for-prevention-of-lymphocele-after-robotic-radical-prostatectomy-and-pelvic-lymph-node-dissection-a-systematic-review-meta-analysis-bayesian-network-meta-analysis-and-meta-regression
#25
REVIEW
David E Hinojosa-González, Gal Saffati, Shane Kronstedt, Troy La, Cedrick Chiu, Eric Wahlstedt, Jeffrey A Jones, Dov Kadmon, Justin Badal, Jennifer M Taylor, Jeremy R Slawin
Lymphocele is one of the most common complications after radical prostatectomy. Multiple authors have proposed the use of vessel sealants or peritoneal interposition techniques as preventive interventions. This study aimed to aggregate and analyze the available literature on different interventions which seek to prevent lymphocele through a Bayesian Network. A systematic review was performed to identify prospective studies evaluating strategies for lymphocele prevention after robot assisted laparoscopic prostatectomy + pelvic lymph node dissection...
April 17, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38627803/management-of-embolic-splenic-abscess-secondary-to-aortic-valve-endocarditis-case-report-and-review-of-literature
#26
REVIEW
Nicolas Nunez-Ordonez, Juan Sebastián Luna, Jaime Camacho Mackenzie, Andrés Felipe Jiménez, Alejandro González, Andrea J Pico, Carlos F Román, Paulo A Cabrera Rivera, Carlos A Villa Hincapié
BACKGROUND: Splenic abscess is a serious complication associated with infective endocarditis. There is still contradicting evidence regarding the optimal treatment pathway including timing of valve intervention and the approach for managing splenic foci. CASE PRESENTATION: We present a case of a hybrid staged approach in which we successfully performed a laparoscopic splenectomy following percutaneous abscess drainage and a delayed aortic valve replacement. CONCLUSIONS: A multidisciplinary teamwork is fundamental in providing optimal care for patients with distant complications associated with infective endocarditis...
April 16, 2024: Journal of Cardiothoracic Surgery
https://read.qxmd.com/read/38627306/exploring-6%C3%A2-years-of-colorectal-cancer-surgery-in-rural-italy-insights-from-648-consecutive-patients-unveiling-successes-and-challenges
#27
JOURNAL ARTICLE
Roberto Santoro, Marta Goglia, Manuela Brighi, Fabio Pio Curci, Pietro Maria Amodio, Domenico Giannotti, Angelo Goglia, Jacopo Mazzetti, Laura Antolino, Antonio Bovino, Costantino Zampaletta, Giovanni Battista Levi Sandri, Enzo Maria Ruggeri
The multidisciplinary management of patients suffering from colorectal cancer (CRC) has significantly increased survival over the decades and surgery remains the only potentially curative option for it. However, despite the implementation of minimally invasive surgery and ERAS pathway, the overall morbidity and mortality remain quite high, especially in rural populations because of urban - rural disparities. The aim of the study is to analyze the characteristics and the surgical outcomes of a series of unselected CRC patients residing in two similar rural areas in Italy...
April 17, 2024: Updates in Surgery
https://read.qxmd.com/read/38627055/acute-diverticulitis-of-the-appendix
#28
JOURNAL ARTICLE
Ahmed Abdelrahim, Yusuf Yusuf, Omer Ali, Haytham Abudeeb
Acute diverticulitis of the appendix (ADA), though uncommon, often presents similarly to acute appendicitis but carries a higher risk of complications such as perforation and malignancy. We report the case of a male patient in his 50s with acute right iliac fossa abdominal pain, diagnosed via CT scan with ADA. Urgent laparoscopic appendicectomy was performed, and the patient was discharged without further issues. This case highlights the importance of promptly identifying and managing such conditions to minimise complications and improve outcomes...
April 16, 2024: BMJ Case Reports
https://read.qxmd.com/read/38626588/impact-of-neoadjuvant-chemotherapy-on-short-term-outcomes-after-simple-and-complex-minimally-invasive-minor-hepatectomy-for-colorectal-liver-metastases-a-propensity-score-matched-and-coarsened-exact-matched-study
#29
JOURNAL ARTICLE
Tijs J Hoogteijling, Mohammad Abu Hilal, Giuseppe Zimmitti, Davit L Aghayan, Andrew G R Wu, Federica Cipriani, Salvatore Gruttadauria, Olivier Scatton, Tran Cong Duy Long, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Alejandro Mejia, James O Park, Fernando Rotellar, Gi Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P Sutcliffe, Johann Pratschke, Chung-Ngai Tang, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I Troisi, Ho Seong Han, Tan To Cheung, Atsushi Sugioka, Safi Dokmak, Kuo Hsin Chen, Rong Liu, David Fuks, Wanguang Zhang, Luca Aldrighetti, Bjørn Edwin, Brian K P Goh
BACKGROUND: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone...
April 2, 2024: European Journal of Surgical Oncology
https://read.qxmd.com/read/38626453/pathophysiology-and-clinical-implications-of-ovarian-endometriomas
#30
JOURNAL ARTICLE
Farr R Nezhat, Ann M Cathcart, Ceana H Nezhat, Camran R Nezhat
Ovarian endometriomas affect many patients with endometriosis and have significant effects on quality of life, fertility, and risk of malignancy. Endometriomas range from small (1-3 cm), densely fibrotic cysts to large (20 cm or greater) cysts with varying degrees of fibrosis. Endometriomas are hypothesized to form from endometriotic invasion or metaplasia of functional cysts or alternatively from ovarian surface endometriosis that bleeds into the ovarian cortex. Different mechanisms of endometrioma formation may help explain the phenotypic variability observed among endometriomas...
April 16, 2024: Obstetrics and Gynecology
https://read.qxmd.com/read/38623096/low-grade-appendiceal-mucinous-neoplasm-causing-equivocal-appendicitis-a-case-report
#31
Evan J Gorgas, Shawn C Dowling
Appendicitis is one of the most common diagnoses that general surgeons encounter in practice. An exceedingly rare cause of this disease is neoplasm. We report the case of a 24-year-old female who presented with non-specific right lower quadrant abdominal pain and equivocal findings of appendicitis and pelvic congestion syndrome on CT imaging. After an extensive work-up, the patient underwent a diagnostic laparoscopy with an appendectomy. The appendix appeared grossly normal; however, on a pathologic review of the specimen, a low-grade appendiceal mucinous neoplasm (LAMN) was found...
March 2024: Curēus
https://read.qxmd.com/read/38622225/laparoscopic-sleeve-gastrectomy-for-premenstrual-syndrome-symptoms-in-patients-with-obesity
#32
JOURNAL ARTICLE
Xiangxin Kong, Yuan Zhang, Ke Song, Ming He, Yin Xian, Xing Xie, Junming Cheng, Yixing Ren
BACKGROUND: Premenstrual syndrome (PMS) is a pathological condition characterized by a series of abnormal physical, psychological, and behavioral symptoms. We evaluated the effectiveness of laparoscopic sleeve gastrectomy (LSG) in the treatment of patients with obesity and PMS. METHODS: In this case-control study, 131 patients with obesity (BMI ≥ 27.5 kg/cm2 ) diagnosed with moderate-to-severe PMS from March 2018 to March 2022 were prospectively selected to undergo LSG or not at their own discretion...
April 15, 2024: Surgical Endoscopy
https://read.qxmd.com/read/38618478/diverticulitis-in-the-under-40-population
#33
JOURNAL ARTICLE
Danisi Jacqueline, Kimberly Lince, Virgil K DeMario, Alexander Zarutskie, Shannon Cisse, Olutayo Sogunro
BACKGROUND: As obesity and lifestyle factors become more prevalent in younger populations, we are diagnosing and treating diverticulitis in younger patients. In this study, the demographics, risk factors for the development, and treatment of acute diverticulitis were assessed focusing on patients under the age of 40. METHODS: A retrospective review of the electronic medical records of a cohort of subjects diagnosed with diverticulitis was performed. Inclusion criteria included patients aged 18-40 who were treated for acute diverticulitis with or without any complications...
March 2024: Curēus
https://read.qxmd.com/read/38618430/laparoscopic-management-of-abdominal-echinococcosis-a-technical-report-on-surgical-techniques-and-outcomes
#34
JOURNAL ARTICLE
Iulian M Slavu, Octavian Munteanu, Valeriu Gheorghita, Florin Filipoiu, Bogdan Ursuț, Raluca Tulin, Ileana Dima, Iulian A Dogaru, Adrian Tulin
This technical report explores the efficacy and methodology of laparoscopic surgery for treating abdominal echinococcosis, a parasitic infection caused by Echinococcus granulosus. We highlight the zoonotic nature of the disease, which predominantly affects the liver and occasionally other organs, noting the challenge of its asymptomatic progression that complicates timely diagnosis and intervention. We detail our surgical technique using a standard laparoscopy kit to address abdominal hydatid cysts, emphasizing the critical importance of preventing cyst rupture and spillage to avoid recurrence and anaphylactic shock...
March 2024: Curēus
https://read.qxmd.com/read/38618359/surgical-management-of-pericaecal-hernia-in-a-virgin-abdomen
#35
Jia Ling Ong, Wei Chuan Tan, Kien Fatt Sean Lee, Kuan Yuen Yeong, Choon Sheong Seow
Internal hernia is an uncommon cause of mechanical small bowel obstruction. This case report details a 66-year-old Chinese male with no prior abdominal surgeries who presented with colicky abdominal pain, abdominal distension, and vomiting. Initial investigations were unyielding, but escalating symptoms prompted a diagnostic laparoscopy. Laparotomy then revealed a closed-loop obstruction through a lateral type pericecal hernia, with a segment of ischemic jejunum. Adhesion bands in the right iliac fossa and a congenital hernia orifice in the mesentery were identified and addressed...
March 2024: Curēus
https://read.qxmd.com/read/38616843/successful-laparoscopic-management-of-zinner-syndrome-in-a-pediatric-patient
#36
Kaushal Kulkarni, Anjan Kumar Dhua, Prabudh Goel, Vishesh Jain, Devendra Kumar Yadav, Sandeep Agarwala, Devasenathipathy Kandasamy
Zinner syndrome, a rare congenital anomaly affecting males, is characterized by atresia of the ejaculatory duct, seminal vesicle cysts, and ipsilateral renal agenesis. This case report details a 2-year-old boy successfully treated with laparoscopic excision of a dilated vas deferens and seminal vesicle cyst. The rarity of Zinner syndrome in pediatric patients underscores the importance of understanding its diagnosis and minimally invasive surgical management.
2024: Journal of Indian Association of Pediatric Surgeons
https://read.qxmd.com/read/38614884/keep-your-attention-closer-to-the-ureters-ureterolysis-in-deep-endometriosis-surgery
#37
REVIEW
Louisa R Chatroux, Jon I Einarsson
Endometriosis surgery involving the ureter poses significant challenges requiring meticulous surgical techniques and vigilant postoperative care. This chapter addresses key aspects of ureterolysis techniques, intraoperative management of ureteral injuries, and postoperative care in the context of endometriosis surgery. Ureterolysis methods aim to isolate and mobilize the ureter while preserving its vascularity. Cold instruments and careful dissection are recommended to prevent thermal injury during surgery...
April 8, 2024: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://read.qxmd.com/read/38613697/laparoscopic-ventral-mesh-rectopexy-in-the-oldest-old-is-safe-the-race-is-run
#38
JOURNAL ARTICLE
E Ergüder, C Verkade, D K Wasowicz, B S Langenhoff, S Altiner, D D E Zimmerman
BACKGROUND: Laparoscopic ventral mesh rectopexy (LVMR) is considered to be the gold standard for managing rectal prolapse. Nevertheless, concerns have been expressed about the use of this procedure in elderly patients. The aim of the current study was to examine the perioperative safety of primary LVMR operations in the oldest old in comparison to younger individuals and to assess our hospital policy of offering LVMR to all patients, regardless of age and morbidity. METHODS: A retrospective study analysed demographic information, operation notes, meshes utilised, operation times, lengths of hospital stay (LOS) and American Society of Anesthesiologists (ASA) scores of patients who underwent LVMR at Elisabeth-TweeSteden Hospital between 2012 and 2023...
April 13, 2024: Techniques in Coloproctology
https://read.qxmd.com/read/38613656/does-the-presence-of-abdominal-wall-adhesions-make-gynecologic-robotic-surgery-difficult
#39
JOURNAL ARTICLE
Takahiro Nozaki, Kosuke Matsuda, Keiko Kagami, Ikuko Sakamoto
This study aimed to assess the status of abdominal wall adhesions resulting from prior surgeries and their impact on the outcomes of robotic surgery. We retrospectively reviewed clinical information, surgical outcomes, and the status of abdominal wall adhesions in patients who underwent gynecologic robotic surgery at Yamanashi Central Hospital, between April 2018 and March 2023. Abdominal wall adhesions were classified into seven locations and their presence was assessed at each site. Among the 768 cases examined, 196 showed the presence of abdominal wall adhesions...
April 13, 2024: Journal of Robotic Surgery
https://read.qxmd.com/read/38613623/a-fatal-misdiagnosis-of-page-kidney-case-report
#40
JOURNAL ARTICLE
Gayan Kumarasinghe, Murugupillai Sivasubramanium, Kasun Bandara Ekanayake, Dhanushka Rambukwella, Bandarage Sanjaya
Page kidney is a condition where external compression of the renal artery and renal parenchyma leads to subsequent ischaemia and activation of renin-angiotensin-aldosterone axis. A 42-year-old female with hirsutism, hypertension and diabetes was diagnosed with a right adrenal mass and underwent laparoscopic adrenalectomy. Her hypertension worsened postoperatively and was managed medically. Subsequently she developed a right flank pain on the fifth postoperative day and died suddenly the next day. Autopsy revealed a pale body with cushingoid appearance...
April 13, 2024: Forensic Science, Medicine, and Pathology
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