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Freeze of Gait in Parkinson's disease

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https://www.readbyqxmd.com/read/29773512/increased-foot-strike-variability-in-parkinson-s-disease-patients-with-freezing-of-gait
#1
Jesal Shah, Lakshmi Pillai, David K Williams, Shannon M Doerhoff, Linda Larson-Prior, Edgar Garcia-Rill, Tuhin Virmani
INTRODUCTION: Freezing of gait (FOG) is a debilitating, late motor complication of Parkinson's disease (PD) that occurs in 50-80% of patients. Gait freezing significantly worsens quality of life by decreasing mobility and increasing falls. Studies have shown that patients with episodic freezing episodes also have deficits in continuous gait. We evaluated whether there was an objective gait correlate to the increased stumbling reported by many patients with gait freezing. METHODS: PD subjects and healthy controls (HC) were enrolled after IRB approval...
May 1, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29754837/effects-of-exercise-on-gait-and-motor-imagery-in-people-with-parkinson-disease-and-freezing-of-gait
#2
Peter S Myers, Marie E McNeely, Kristen A Pickett, Ryan P Duncan, Gammon M Earhart
INTRODUCTION: Exercise improves gait in Parkinson disease (PD), but whether exercise differentially affects people with PD with (freezers) and without freezing of gait (non-freezers) remains unclear. This study examines exercise's effects on gait performance, neural correlates related to these effects, and potential neural activation differences between freezers and non-freezers during motor imagery (MI) of gait. METHODS: Thirty-seven participants from a larger exercise intervention completed behavioral assessments and functional magnetic resonance imaging (fMRI) scans before and after a 12-week exercise intervention...
May 8, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29708870/validation-of-freezing-of-gait-monitoring-using-smartphone
#3
Han Byul Kim, Hong Ji Lee, Woong Woo Lee, Sang Kyong Kim, Hyo Seon Jeon, Hye Young Park, Chae Won Shin, Won Jin Yi, Beomseok Jeon, Kwang S Park
BACKGROUND: Freezing of gait (FOG) is a commonly observed motor symptom for patients with Parkinson's disease (PD). The symptoms of FOG include reduced step lengths or motor blocks, even with an evident intention of walking. FOG should be monitored carefully because it not only lowers the patient's quality of life, but also significantly increases the risk of injury. INTRODUCTION: In previous studies, patients had to wear several sensors on the body and another computing device was needed to run the FOG detection algorithm...
April 30, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29696615/influence-of-cognitive-impairment-on-the-freezing-of-gait-in-non-demented-people-with-parkinson-s-disease
#4
J M Cancela, C M Nascimento, S Varela, M Seijo-Martinez, L Lorenzo-Lopez, J C Millan-Calenti, C Dominguez-Vivero, C Ayan
INTRODUCTION: Freezing of gait (FOG) is a motor disturbance usually appearing in advanced Parkinson's disease (PD). Cognitive and executive function seems to play an important role in this phenomenon. AIM: To investigate if cognitive and kinematic parameters correlate with FOG in PD patients without dementia. PATIENTS AND METHODS: We conducted an observational cross-sectional study. Participants were classified in two groups: freezers and non-freezers...
May 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29673947/handwritten-dynamics-assessment-through-convolutional-neural-networks-an-application-to-parkinson-s-disease-identification
#5
Clayton R Pereira, Danilo R Pereira, Gustavo H Rosa, Victor H C Albuquerque, Silke A T Weber, Christian Hook, João P Papa
BACKGROUND AND OBJECTIVE: Parkinson's disease (PD) is considered a degenerative disorder that affects the motor system, which may cause tremors, micrography, and the freezing of gait. Although PD is related to the lack of dopamine, the triggering process of its development is not fully understood yet. METHODS: In this work, we introduce convolutional neural networks to learn features from images produced by handwritten dynamics, which capture different information during the individual's assessment...
April 16, 2018: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29662465/the-length-of-snca-rep1-microsatellite-may-influence-cognitive-evolution-in-parkinson-s-disease
#6
Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Donata Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Giacomo P Comi, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi
Background: Alpha-synuclein is a constituent of Lewy bodies and mutations of its gene cause familial Parkinson's disease (PD). A previous study showed that a variant of the alpha-synuclein gene ( SNCA ), namely the 263 bp allele of Rep1 was associated with faster motor progression in PD. On the contrary, a recent report failed to detect a detrimental effect of Rep1 263 on both motor and cognitive outcomes in PD. Aim of this study was to evaluate the influence of the Rep1 variants on disease progression in PD patients...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29648576/life-space-mobility-in-parkinson-s-disease-associations-with-motor-and-non-motor-symptoms
#7
Merja Rantakokko, Susanne Iwarsson, Björn Slaug, Maria H Nilsson
Background: To describe life-space mobility and explore associations of motor and non-motor symptoms with life-space mobility in people with Parkinson's disease (PD). Methods: 164 community-dwelling persons with PD (mean age 71.6 years, 64.6% men) received a postal survey and a subsequent home visit. Motor assessments included perceived walking difficulties (Walk-12G), mobility (Timed Up and Go test), motor symptoms (UPDRS-III) and freezing of gait (item 3, FOG-Qsa)...
April 10, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29643593/characteristics-associated-with-freezing-of-gait-in-actual-daily-living-in-parkinson-s-disease
#8
Mitsuaki Ishii, Kohei Okuyama
[Purpose] Parkinson's disease (PD) patients often freeze in actual daily living but seldom in clinical setting. This study aimed to identify the factors contributing to freezing of gait (FOG). [Subjects and Methods] The participants included 28 adults with PD. Principal component analysis was used to investigate the characteristics of 14 common FOG situations adopted from previous studies. Cluster analysis classified the subjects into four groups. Kruskal-Wallis test was performed to compare the PD Questionnaire-39 mobility dimension between the groups...
December 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29629527/an-8-week-low-intensity-progressive-cycling-training-improves-motor-functions-in-patients-with-early-stage-parkinson-s-disease
#9
Hsiu Chen Chang, Chin Song Lu, Wei Da Chiou, Chiung Chu Chen, Yi Hsin Weng, Ya Ju Chang
BACKGROUND AND PURPOSE: The effects of high-intensity cycling as an adjuvant therapy for early-stage Parkinson's disease (PD) were highlighted recently. However, patients experience difficulties in maintaining these cycling training programs. The present study investigated the efficacy of cycling at a mild-to-moderate intensity in early-stage PD. METHODS: Thirteen PD patients were enrolled for 16 serial cycling sessions over a 2-month period. Motor function was assessed using the Unified Parkinson's Disease Rating Scale part III (UPDRS III) and Timed Up and Go (TUG) test as primary outcomes...
April 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29623988/levodopa-carbidopa-intestinal-gel-is-the-naso-jejunal-phase-a-redundant-convention
#10
Nirosen Vijiaratnam, Sarah Hewer, Sue Varley, Eldho Paul, Kelly L Bertram, Will Lee, Matthew Ligtermoet, David R Williams
Levodopa-carbidopa intestinal gel (LCIG) is an effective treatment for Parkinson disease. Initiating therapy involves an initial naso-jejunal (NJ) titration phase. The NJ phase is prolonged with significant morbidity. The aim of this study is to assess the impact of proceeding without the NJ phase on resource utilisation and the outcomes of patients. Twenty-five patients were started on LCIG using the patients existing levodopa equivalent dose (LED). We recorded change in LED, length of hospital stay, readmission rates and use of outpatient services and clinical outcomes within 6 months...
April 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29621320/medication-and-trial-duration-influence-postural-and-pointing-parameters-during-a-standing-repetitive-pointing-task-in-individuals-with-parkinson-s-disease
#11
Deborah A Jehu, Hiram Cantù, Allen Hill, Caroline Paquette, Julie N Côté, Julie Nantel
We aimed to determine the effects of levodopa medication on the performance of a repetitive pointing task while standing, and to investigate the optimal trial duration in individuals with Parkinson's disease, and older adults. Seventeen individuals with Parkinson's disease (5 freezers) and 9 older adults stood on force platforms for 30 s and 120 s while performing a bilateral repetitive pointing task, tracked by motion capture. Participants with Parkinson's disease were assessed on and off medication and older adults were also assessed on separate days...
2018: PloS One
https://www.readbyqxmd.com/read/29616302/alterations-in-white-matter-network-topology-contribute-to-freezing-of-gait-in-parkinson-s-disease
#12
Julie M Hall, James M Shine, Kaylena A Ehgoetz Martens, Moran Gilat, Kathryn M Broadhouse, Jennifer Y Y Szeto, Courtney C Walton, Ahmed A Moustafa, Simon J G Lewis
Freezing of gait (FOG) is a common symptom in advanced Parkinson's disease (PD). Despite current advances, the neural mechanisms underpinning this disturbance remain poorly understood. To this end, we investigated the structural organisation of the white matter connectome in PD freezers and PD non-freezers. We hypothesized that freezers would show an altered network architecture, which could hinder the effective information processing that characterizes the disorder. Twenty-six freezers and twenty-four well-matched non-freezers were included in this study...
April 3, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29606604/predictors-of-camptocormia-in-patients-with-parkinson-s-disease-a-prospective-study-from-southwest-china
#13
Ruwei Ou, Hui Liu, Yanbing Hou, Wei Song, Bei Cao, Qianqian Wei, Xiaoqin Yuan, Yongping Chen, Bi Zhao, Huifang Shang
BACKGROUND: Camptocormia is becoming increasingly recognized as a prominent phenomenon in Parkinson's disease (PD). OBJECTIVE: This study aims to investigate the clinical predictors of future camptocormia in a cohort of PD patients. METHODS: A total of 263 PD patients without camptocormia were prospectively monitored for approximately 3 years. The end-point was the occurrence of camptocormia. RESULTS: Overall, camptocormia was observed in 23 patients (8...
March 27, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29602542/decreased-interhemispheric-homotopic-connectivity-in-parkinson-s-disease-patients-with-freezing-of-gait-a-resting-state-fmri-study
#14
Junyi Li, Yongsheng Yuan, Min Wang, Jiejin Zhang, Li Zhang, Siming Jiang, Xixi Wang, Jian Ding, Kezhong Zhang
INTRODUCTION: Freezing of gait is a common complaint in patients with Parkinson's disease (PD). However, the neural bases of freezing of gait in PD remain uncertain. Existing studies on PD patients with freezing of gait (PD-FOG+) have reported damage of the corpus callosum, the largest commissural bundle of the brain. Thus, in this study we explored homotopic connectivity to investigate FOG-related interehemispheric alterations METHODS: A total of 21 PD-FOG + patients, 33 PD patients without freezing of gait (PD-FOG-), and 24 matched healthy controls were recruited...
March 26, 2018: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/29577677/phase-determination-using-chromosomal-microarray-and-fluorescence-in-situ-hybridization-in-a-patient-with-early-onset-parkinson-disease-and-two-deletions-in-prkn
#15
Eli S Williams, Matthew J Barrett, Radhika Dhamija, Lisa Toran, Chelsea Chambers, Mani S Mahadevan, Wendy L Golden
BACKGROUND: Mutations in the parkin gene (PRKN) are the most commonly identified genetic factors in early onset Parkinson disease (EOPD), with biallelic mutations, resulting in a clinical phenotype. However, normal variation is also common in PRKN, particularly in the form of copy number variation (CNV), challenging interpretation of genetic testing results. Here we report a case of a 29-year-old male with EOPD and two deletions in PRKN detected by chromosomal microarray (CMA). METHODS: The proband was clinically examined by a neurologist for postural instability with frequent falls, bradykinesia, gait freezing with festination, and hypophonia...
March 25, 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29572571/exploring-the-relationship-between-motor-impairment-vascular-burden-and-cognition-in-parkinson-s-disease
#16
Tanja Stojkovic, Elka Stefanova, Ivan Soldatovic, Vladana Markovic, Iva Stankovic, Igor Petrovic, Federica Agosta, Sebastiano Galantucci, Massimo Filippi, Vladimir Kostic
OBJECTIVE: To determine frequency and type of cognitive disorders in cross-sectional analysis of a Parkinson's disease (PD) cohort, and explore its relations to motor symptoms, modifiable vascular risk factors and white matter lesions (WML) volume. METHODS: In a group of 133 PD patients, mild cognitive impairment (PD-MCI) and dementia (PDD) were diagnosed according to Movement Disorders Society Task Force criteria (level 2 for PD-MCI). Detailed motor measurements were applied, including rigidity, axial, bradykinesia, tremor and postural instability gait disorders (PIGD) scores...
March 23, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29571872/alterations-of-regional-homogeneity-in-freezing-of-gait-in-parkinson-s-disease
#17
Caihong Zhou, Xiaoling Zhong, Yongzhe Yang, Wanqun Yang, Lijuan Wang, Yuhu Zhang, Kun Nie, Jianmin Xu, Biao Huang
INTRODUCTION: Freezing of gait (FOG) is a serious complication in patients with Parkinson's disease (PD), and is more common in the late state of the disease. The high risk of falling in patients with FOG impacts their quality of life. OBJECTIVE: To explore altered neuroactivity related to cognitive and executive function of PD patients with FOG. METHODS: Fourteen PD patients with FOG (FOG+), 20 PD patients without FOG (FOG-), and 18 normal controls (NC) were enrolled...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29571090/impaired-set-shifting-is-associated-with-previous-falls-in-individuals-with-and-without-parkinson-s-disease
#18
J Lucas McKay, Kimberly C Lang, Lena H Ting, Madeleine E Hackney
BACKGROUND: Individuals with Parkinson's disease (PD) are at increased risk for falls, which lead to substantial morbidity and mortality. Understanding the motor and non-motor impairments associated with falls in PD is critical to informing prevention strategies. In addition to motor symptoms, individuals with PD exhibit non-motor deficits, including impaired set shifting, an aspect of executive function related to cognitive flexibility that can be measured quickly with the Trailmaking Test...
March 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29554851/the-impact-of-dual-tasking-on-postural-stability-in-people-with-parkinson-s-disease-with-and-without-freezing-of-gait
#19
Esther M J Bekkers, Kim Dockx, Surendar Devan, Sam Van Rossom, Sabine M P Verschueren, Bastiaan R Bloem, Alice Nieuwboer
BACKGROUND: Postural instability and freezing of gait (FOG) are major problems in patients with Parkinson's disease (PD), and both contribute to falls. However, the interrelationship between these 2 deficits is still unclear. OBJECTIVE: This study investigated whether dual-tasking influenced postural control differently in freezers (FOG+) and nonfreezers (FOG-). METHODS: Thirty-three patients with PD (19 FOG+, 14 FOG-, well-matched) and 28 healthy controls underwent 4 postural control tasks, consisting of standing on either stable or unstable surfaces with eyes open or closed...
February 2018: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/29550375/freezing-of-gait-promising-avenues-for-future-treatment
#20
REVIEW
Moran Gilat, Ana Lígia Silva de Lima, Bastiaan R Bloem, James M Shine, Jorik Nonnekes, Simon J G Lewis
Freezing of gait is a devastating symptom of Parkinson's disease and other forms of parkinsonism. It poses a major burden on both patients and their families, as freezing often leads to falls, fall-related injuries and a loss of independence. Treating freezing of gait is difficult for a variety of reasons: it has a paroxysmal and unpredictable nature; a multifaceted pathophysiology, with an interplay between motor elements (disturbed stepping mechanisms) and non-motor elements (cognitive decline, anxiety); and a complex (and likely heterogeneous) underlying neural substrate, involving multiple failing neural networks...
March 12, 2018: Parkinsonism & related Disorders
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