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Freeze of Gait in Parkinson's disease

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https://www.readbyqxmd.com/read/28702192/freezing-of-gait-is-an-early-clinical-feature-of-progressive-supranuclear-palsy
#1
Yasushi Osaki, Yukari Morita, Yuka Miyamoto, Kounosuke Furuta, Hirokazu Furuya
BACKGROUND AND AIM: Early clinical diagnosis of progressive supranuclear palsy (PSP) remains challenging. AIM: We attempted to identify any sign or symptom to diagnose PSP earlier. METHODS: A total of 401 patients, 40 with PSP and 361 with other neurodegenerative disorders, were included. We followed these patients for at least 1 year since 2009. We reviewed the signs and symptoms of patients with PSP in a standardized manner, and observed four manifestations: "vertical supranuclear gaze abnormality," "movement disorders," "pseudobulbar palsy" and "dementia of frontal type...
May 2017: Neurology and Clinical Neuroscience
https://www.readbyqxmd.com/read/28698150/freezing-of-gait-is-associated-with-cognitive-impairment-in-patients-with-parkinson-disease
#2
Zhiwen Yao, Yuan Shao, Xiang Han
OBJECTIVE: To explore whether the cognitive impairment is correlated with freezing of gait (FOG) in patients with Parkinson disease (PD). METHODS: A total of 186 patients with Parkinson disease (104 patients with FOG and 82 patients with no clinical history of freezing behavior) and 125 healthy individuals were selected for this study. Neuropsychological assessments, including the scales for outcomes in Parkinson disease cognition, unified Parkinson's disease rating scale, and Hamilton depression/anxiety rating scale etc...
July 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28673611/effects-of-curved-walking-training-on-curved-walking-performance-and-freezing-of-gait-in-individuals-with-parkinson-s-disease-a-randomized-controlled-trial
#3
Fang-Yu Cheng, Yea-Ru Yang, Yih-Ru Wu, Shih-Jung Cheng, Ray-Yau Wang
INTRODUCTION: The purpose of this study was to investigate the effects of curved-walking training (CWT) on curved-walking performance and freezing of gait (FOG) in people with Parkinson's disease (PD). METHODS: Twenty-four PD subjects were recruited and randomly assigned to the CWT group or control exercise (CE) group and received 12 sessions of either CWT with a turning-based treadmill or general exercise training for 30 min followed by 10 min of over-ground walking in each session for 4-6 weeks...
June 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28659862/usability-of-three-dimensional-augmented-visual-cues-delivered-by-smart-glasses-on-freezing-of-gait-in-parkinson-s-disease
#4
Sabine Janssen, Benjamin Bolte, Jorik Nonnekes, Marian Bittner, Bastiaan R Bloem, Tjitske Heida, Yan Zhao, Richard J A van Wezel
External cueing is a potentially effective strategy to reduce freezing of gait (FOG) in persons with Parkinson's disease (PD). Case reports suggest that three-dimensional (3D) cues might be more effective in reducing FOG than two-dimensional cues. We investigate the usability of 3D augmented reality visual cues delivered by smart glasses in comparison to conventional 3D transverse bars on the floor and auditory cueing via a metronome in reducing FOG and improving gait parameters. In laboratory experiments, 25 persons with PD and FOG performed walking tasks while wearing custom-made smart glasses under five conditions, at the end-of-dose...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28653213/external-input-for-gait-in-people-with-parkinson-s-disease-with-and-without-freezing-of-gait-one-size-does-not-fit-all
#5
Pieter Ginis, Elke Heremans, Alberto Ferrari, Esther M J Bekkers, Colleen G Canning, Alice Nieuwboer
Cueing or feedback provided when gait deviates from a predefined goal (intelligent input) can now be provided with wearable technology for Parkinson's disease (PD). As people with and without freezing of gait (FOG) have distinct cognitive profiles, they may respond differently to various types of input. This study compared the effects of four input modalities during prolonged walking and explored the relationship with cognition, subjective preference, and FOG. Participants (15 with and 13 without FOG) walked 30 min while exposed to continuous cueing; intelligent cueing; intelligent feedback; or no input...
July 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28634343/falling-direction-can-predict-the-mechanism-of-recurrent-falls-in-advanced-parkinson-s-disease
#6
Jinyoung Youn, Yasuyuki Okuma, Minho Hwang, Dongyeop Kim, Jin Whan Cho
Falls are a common and disabling symptom in patients with Parkinson's disease (PD). For prevention, it is important to understand the pathophysiology of falls in PD patients, but the predictors for the possible mechanisms underlying such falls have not been clearly elucidated. In this prospective observational study, we investigated the implications of falling direction to predict the mechanisms of recurrent falls in PD patients. We enrolled 62 recurrent fallers with PD and divided them into two groups according to the main falling directions: 45 PD fallers who fell forward (forward fallers), and 17 PD fallers who fell in the other directions (non-forward fallers)...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629269/aquatic-obstacle-training-improves-freezing-of-gait-in-parkinson-s-disease-patients-a-randomized-controlled-trial
#7
Zhizhong Zhu, Miaomiao Yin, Liling Cui, Ying Zhang, Weijia Hou, Yaqing Li, Hua Zhao
OBJECTIVE: Our aim was to evaluate the effect of aquatic obstacle training on balance parameters in comparison with a traditional aquatic therapy in patients with Parkinson's disease. DESIGN: A randomized single-blind controlled trial. SETTING: Outpatients in the rehabilitation department. SUBJECTS: A total of 46 patients with Parkinson's disease in Hoehn-Yahr stage 2-3. INTERVENTIONS: Participants were randomly assigned to (1) aquatic therapy or (2) obstacle aquatic therapy...
June 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28607801/quantitative-analysis-of-motor-status-in-parkinson-s-disease-using-wearable-devices-from-methodological-considerations-to-problems-in-clinical-applications
#8
REVIEW
Masahiko Suzuki, Hiroshi Mitoma, Mitsuru Yoneyama
Long-term and objective monitoring is necessary for full assessment of the condition of patients with Parkinson's disease (PD). Recent advances in biotechnology have seen the development of various types of wearable (body-worn) sensor systems. By using accelerometers and gyroscopes, these devices can quantify motor abnormalities, including decreased activity and gait disturbances, as well as nonmotor signs, such as sleep disturbances and autonomic dysfunctions in PD. This review discusses methodological problems inherent in wearable devices...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28606769/computer-assisted-cognitive-rehabilitation-on-freezing-of-gait-in-parkinson-s-disease-a-pilot-study
#9
Valeria Dibilio, Alessandra Nicoletti, Giovanni Mostile, Giacomo Portaro, Antonina Luca, Francesco Patti, Mario Zappia
BACKGROUND: In Parkinson's Disease (PD), effects of a cognitive training have been systematically evaluated only for cognitive and behavioral outcome measures, with mild to moderate effects. Despite the demonstrated interplay between cognition and gait, no studies have investigated the effect of cognitive rehabilitation protocols on gait in PD. METHODS: Patients affected by PD with freezing of gait were treated twice a week for six weeks with one hour sessions of computer-assisted training of attention ability and information processing tasks...
July 27, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28555128/a-case-of-apparent-upper-body-freezing-in-parkinsonism-while-using-a-wheelchair
#10
Samuel T Nemanich, Marie E McNeely, Gammon M Earhart, Scott A Norris, Kevin J Black
Freezing of gait (FOG) is a common, disabling gait disturbance in Parkinson's disease (PD) and other Parkinsonian syndromes. Freezing also occurs during non-gait movements involving the upper limbs. The mechanisms underlying freezing are complex, likely involving motor, cognitive, and sensory systems that contribute to the episodes. Here, we reported a 60-year-old female with a 24-year history of parkinsonism who experienced significant FOG when ambulatory. Disease progression resulted in her permanent use of a powered wheelchair...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28553677/low-to-moderate-relationships-between-gait-and-postural-responses-in-parkinson-disease
#11
Ellen N Sutter, Katie J Seidler, Ryan P Duncan, Gammon M Earhart, Marie E McNeely
OBJECTIVE: To evaluate the relationship between spatiotemporal parameters of forward and backward gait and quality of compensatory stepping responses in forward and backward directions in people with Parkinson's disease with and without freezing of gait. DESIGN: Cross-sectional analysis. SUBJECTS: A total of 111 individuals with mild to moderate Parkinson's disease. METHODS: Forward and backward gait velocity and step length were evaluated using a GAITRite walkway...
May 29, 2017: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28544951/clinical-balance-scales-indicate-worse-postural-control-in-people-with-parkinson-s-disease-who-exhibit-freezing-of-gait-compared-to-those-who-do-not-a-meta-analysis
#12
REVIEW
Esther M J Bekkers, Bauke W Dijkstra, Kim Dockx, Elke Heremans, Sabine M P Verschueren, Alice Nieuwboer
Postural instability and freezing of gait (FOG) are key features of Parkinson's disease (PD) that are closely related to falls. Uncovering the postural control differences between individuals with and without FOG contributes to our understanding of the relationship between these phenomena. The objective of this meta-analysis was to investigate whether postural control deficits, as detected by clinical balance scales, were more apparent in FOG+ compared to FOG-. Furthermore, we aimed to identify whether different scales were equally sensitive to detect postural control deficits and whether medication affected postural control differentially in each subgroup...
July 2017: Gait & Posture
https://www.readbyqxmd.com/read/28529730/effect-of-low-versus-high-frequency-stimulation-on-freezing-of-gait-and-other-axial-symptoms-in-parkinson-patients-with-bilateral-stn-dbs-a-mini-review
#13
REVIEW
Tao Xie, Mahesh Padmanaban, Lisa Bloom, Ellen MacCracken, Breanna Bertacchi, Abraham Dachman, Peter Warnke
Some studies have shown that low frequency stimulation (LFS, most commonly 60 Hz), compared to high frequency stimulation (HFS, most commonly 130 Hz), has beneficial effects, short-term or even long-term, on improving freezing of gait (FOG) and other axial symptoms, including speech and swallowing function, in Parkinson disease (PD) patients with bilateral subthalamic nucleus deep brain stimulation (STN DBS). However, other studies failed to confirm this. It seems not clear what determines the difference in response to LFS...
2017: Translational Neurodegeneration
https://www.readbyqxmd.com/read/28521148/dual-task-interference-on-postural-sway-postural-transitions-and-gait-in-people-with-parkinson-s-disease-and-freezing-of-gait
#14
Ana Claudia de Souza Fortaleza, Martina Mancini, Patty Carlson-Kuhta, Laurie A King, John G Nutt, Eliane Ferrari Chagas, Ismael Forte Freitas, Fay B Horak
Freezing of gait (FoG) is associated with less automatic gait and more impaired cognition, balance and postural transitions compared to people with PD who do not have FoG. However, it is unknown whether dual-task cost during postural sway, postural transitions (such as gait initiation and turning), and gait are more in subjects with Parkinson's disease (PD) who have freezing of gait (FoG+) compared to those who do not have FoG (FoG-). Here, we hypothesized that the effects of a cognitive dual task on postural sway, postural transitions and gait would be larger in FoG+ than FoG-...
July 2017: Gait & Posture
https://www.readbyqxmd.com/read/28511252/diagnosis-and-management-of-parkinson-s-disease
#15
Arjun Tarakad, Joseph Jankovic
Despite numerous efforts to identify specific and sensitive biomarkers, the diagnosis of Parkinson's disease (PD) is still based on clinical criteria that include the presence of a combination of cardinal motor features (tremor, rigidity, bradykinesia, and postural instability), other motor features (including freezing of gait and abnormal postures), and numerous nonmotor features. In addition, the presence of atypical features may suggest an alternative diagnosis. Levodopa therapy remains the gold standard in the management of motor features of PD...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28509934/the-role-of-the-prefrontal-cortex-in-freezing-of-gait-in-parkinson-s-disease-insights-from-a-deep-repetitive-transcranial-magnetic-stimulation-exploratory-study
#16
Moria Dagan, Talia Herman, Anat Mirelman, Nir Giladi, Jeffrey M Hausdorff
Freezing of Gait (FOG) is one of the most debilitating gait impairments in Parkinson's disease (PD), leading to increased fall risk and reduced health-related quality of life. The utility of parkinsonian medications is often limited in the case of FOG and it frequently becomes dopamine resistant. Recent studies have suggested that pre-frontal cortex (PFC) dysfunction contributes to FOG; however, most previous findings provide only indirect evidence. To better understand the role of the PFC, we aimed to investigate the impact of high frequency, deep, repetitive transcranial magnetic stimulation (drTMS) of the medial PFC on FOG and its mediators...
August 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28505983/subthalamic-nucleus-deep-brain-stimulation-in-parkinson-s-disease-the-effect-of-varying-stimulation-parameters
#17
Viswas Dayal, Patricia Limousin, Thomas Foltynie
Subthalamic Nucleus Deep Brain Stimulation (STN DBS) is a well-established and effective treatment modality for selected patients with Parkinson's disease (PD). Since its advent, systematic exploration of the effect of stimulation parameters including the stimulation intensity, frequency, and pulse width have been carried out to establish optimal therapeutic ranges. This review examines published data on these stimulation parameters in terms of efficacy of treatment and adverse effects. Altering stimulation intensity is the mainstay of titration in DBS programming via alterations in voltage or current settings, and is characterised by a lower efficacy threshold and a higher side effect threshold which define the therapeutic window...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28505982/factors-contributing-to-perceived-walking-difficulties-in-people-with-parkinson-s-disease
#18
Manzur Kader, Susann Ullén, Susanne Iwarsson, Per Odin, Maria H Nilsson
BACKGROUND: While walking difficulties are common in people with Parkinson's disease (PD), little is known about factors that independently contribute to their perceived walking difficulties. OBJECTIVE: To identify factors that independently contribute to perceived walking difficulties in people with PD. METHODS: This study involved 243 (62% men) participants; their mean (min-max) age and PD duration were 70 (45-93) and 8 (1-43) years, respectively...
2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28439757/when-is-higher-level-cognitive-control-needed-for-locomotor-tasks-among-patients-with-parkinson-s-disease
#19
Inbal Maidan, Hagar Bernad-Elazari, Nir Giladi, Jeffrey M Hausdorff, Anat Mirelman
Turning has been implicated as a complex task that requires both motor and cognitive resources. Accumulating evidence shows that patients with Parkinson's disease (PD) require more steps and more time to complete a turn, however, the role of the prefrontal cortex during turning is not clear. Forty nine patients with PD without freezing of gait (mean age 71.7 ± 1.0 years; 67% men, disease duration 9.7 ± 1.3 years) performed motor and cognitive tests. Prefrontal activation, specifically in Brodmann area 10 (BA10), during turning and usual walking was measured using functional near infrared spectroscopy (fNIRS)...
April 24, 2017: Brain Topography
https://www.readbyqxmd.com/read/28398265/a-waist-worn-inertial-measurement-unit-for-long-term-monitoring-of-parkinson-s-disease-patients
#20
Daniel Rodríguez-Martín, Carlos Pérez-López, Albert Samà, Andreu Català, Joan Manuel Moreno Arostegui, Joan Cabestany, Berta Mestre, Sheila Alcaine, Anna Prats, María de la Cruz Crespo, Àngels Bayés
Inertial measurement units (IMUs) are devices used, among other fields, in health applications, since they are light, small and effective. More concretely, IMUs have been demonstrated to be useful in the monitoring of motor symptoms of Parkinson's disease (PD). In this sense, most of previous works have attempted to assess PD symptoms in controlled environments or short tests. This paper presents the design of an IMU, called 9 × 3, that aims to assess PD symptoms, enabling the possibility to perform a map of patients' symptoms at their homes during long periods...
April 11, 2017: Sensors
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