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Freeze of Gait in Parkinson's disease

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https://www.readbyqxmd.com/read/28199357/home-detection-of-freezing-of-gait-using-support-vector-machines-through-a-single-waist-worn-triaxial-accelerometer
#1
Daniel Rodríguez-Martín, Albert Samà, Carlos Pérez-López, Andreu Català, Joan M Moreno Arostegui, Joan Cabestany, Àngels Bayés, Sheila Alcaine, Berta Mestre, Anna Prats, M Cruz Crespo, Timothy J Counihan, Patrick Browne, Leo R Quinlan, Gearóid ÓLaighin, Dean Sweeney, Hadas Lewy, Joseph Azuri, Gabriel Vainstein, Roberta Annicchiarico, Alberto Costa, Alejandro Rodríguez-Molinero
Among Parkinson's disease (PD) symptoms, freezing of gait (FoG) is one of the most debilitating. To assess FoG, current clinical practice mostly employs repeated evaluations over weeks and months based on questionnaires, which may not accurately map the severity of this symptom. The use of a non-invasive system to monitor the activities of daily living (ADL) and the PD symptoms experienced by patients throughout the day could provide a more accurate and objective evaluation of FoG in order to better understand the evolution of the disease and allow for a more informed decision-making process in making adjustments to the patient's treatment plan...
2017: PloS One
https://www.readbyqxmd.com/read/28193533/effect-of-dual-mode-and-dual-site-non-invasive-brain-stimulation-on-freezing-of-gait-in-patients-with-parkinson-s-disease
#2
Won Hyuk Chang, Min Soo Kim, Eunhee Park, Jin Whan Cho, Jinyoung Youn, Yun Kwan Kim, Yun-Hee Kim
OBJECTIVE: To investigate the effect of dual-mode non-invasive brain stimulation (NIBS) with high-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex of the lower leg and anodal transcranial direct current stimulation (tDCS) over the left dorsolateral prefrontal cortex compared with rTMS alone in patients with Parkinson's disease (PD) with freezing of gait (FOG). DESIGN: Randomized, double-blind, controlled study. SETTING: Outpatient rehabilitation clinics...
February 10, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28186875/freezing-of-gait-detection-in-parkinson-s-disease-a-subject-independent-detector-using-anomaly-scores
#3
Thuy T Pham, Steven T Moore, Simon J G Lewis, Diep N Nguyen, Eryk Dutkiewicz, Andrew J Fuglevand, Alistair L McEwan, Philip H W Leong
Freezing of gait (FoG) is common in Parkinsonian gait and strongly relates to falls. Current clinical FoG assessments are patients' self-report diaries and experts' manual video analysis. Both are subjective and yield moderate reliability. Existing detection algorithms have been predominantly designed in subject-dependent settings. In this work, we aim to develop an automated FoG detector for subject-independent. After extracting highly relevant features, we apply anomaly detection techniques to detect FoG events...
February 7, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28167093/effect-of-cue-timing-and-modality-on-gait-initiation-in-parkinson-s-disease-with-freezing-of-gait
#4
Chiahao Lu, Sommer L Amundsen Huffmaster, Paul J Tuite, Jacqueline M Vachon, Colum D MacKinnon
OBJECTIVE: To examine the effects of cue timing, across three sensory modalities, on anticipatory postural adjustments (APAs) during gait initiation in people with Parkinson's disease (PD). DESIGN: Observational study. SETTING: Biomechanics research laboratory. PARTICIPANTS: Twenty-five individuals with idiopathic PD (11 with freezing of gait, FOG) were studied in the off-levodopa state (12-hour overnight withdrawal)...
February 3, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28160752/motor-preparation-rather-than-decision-making-differentiates-parkinson-s-disease-patients-with-and-without-freezing-of-gait
#5
John S Butler, Conor Fearon, Isabelle Killane, Saskia M Waechter, Richard B Reilly, Timothy Lynch
OBJECTIVE: Freezing of gait (FOG) is a brief, episodic phenomenon affecting over half of people with Parkinson's disease (PD) and leads to significant morbidity. The pathophysiology of FOG remains poorly understood but is associated with deficits in cognitive function and motor preparation. METHOD: We studied 20 people with PD (10 with FOG, 10 without FOG) and performed a timed response target detection task while electroencephalographic data were acquired. We analysed the data to detect and examine cortical markers of cognitive decision making (P3b or centroparietal positivity, CPP) and motor readiness potential...
December 28, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28151878/a-training-approach-to-improve-stepping-automaticity-while-dual-tasking-in-parkinson-s-disease-a-prospective-pilot-study
#6
Taylor Chomiak, Alexander Watts, Nicole Meyer, Fernando V Pereira, Bin Hu
BACKGROUND: Deficits in motor movement automaticity in Parkinson's disease (PD), especially during multitasking, are early and consistent hallmarks of cognitive function decline, which increases fall risk and reduces quality of life. This study aimed to test the feasibility and potential efficacy of a wearable sensor-enabled technological platform designed for an in-home music-contingent stepping-in-place (SIP) training program to improve step automaticity during dual-tasking (DT). METHODS: This was a 4-week prospective intervention pilot study...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28113199/smart-gait-aid-glasses-for-parkinson-s-disease-patients
#7
DaeHan Ahn, Hyerim Chung, Ho-Won Lee, Kyunghun Kang, Pan-Woo Ko, Nam Sung Kim, Taejoon Park
Parkinson's disease (PD) is a chronic progressive disease caused by loss of dopaminergic neurons in the substantia nigra, degenerating the nervous system of a patient over time. Freezing of gait (FOG), which is a form of akinesia, is a symptom of PD. Meanwhile, recent studies show that the gait of PD patients experiencing FOG can be significantly improved by providing the regular visual or auditory patterns for the patients. In this paper, we propose a gait-aid system built upon smart glasses. Our system continuously monitors the gait and so on of a PD patient to detect FOG, and upon detection of FOG it projects visual patterns on the glasses as if the patterns were actually on the floor...
January 19, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28106569/cerebellar-volume-and-executive-function-in-parkinson-disease-with-and-without-freezing-of-gait
#8
Peter S Myers, Marie E McNeely, Jonathan M Koller, Gammon M Earhart, Meghan C Campbell
BACKGROUND: Freezing of gait (FOG) affects approximately 50% of people with Parkinson Disease (PD), impacting quality of life and placing financial and emotional strain on the individual and caregivers. People with PD and FOG have similar deficits in motor adaptation and cognition as individuals with cerebellar lesions, indicating the cerebellum may play a role in FOG. OBJECTIVE: To examine potential differences in cerebellar volumes and their relationships with cognition between PD with (FOG+) and without FOG (FOG-)...
January 17, 2017: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/28088380/aquatic-exercise-therapy-for-people-with-parkinson-s-disease-a-randomized-controlled-trial
#9
Louise M Carroll, Daniele Volpe, Meg E Morris, Jean Saunders, Amanda M Clifford
OBJECTIVE: To evaluate the effects of aquatic exercise therapy on gait variability and disability compared to usual care for people with Parkinson's disease (PD). DESIGN: Single-blind randomized control trial (RCT). SETTING: A community based hydrotherapy pool in Ireland. PARTICIPANTS: Twenty one individuals with PD (Hoehn-Yahr Stages I-III). INTERVENTIONS: Participants were randomly assigned to either an aquatic exercise therapy group (45 minutes, twice a week for 6 weeks) or a control group that received usual care...
January 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28031995/prevalence-of-progressive-supranuclear-palsy-in-yonago-change-throughout-a-decade
#10
Hiroshi Takigawa, Michio Kitayama, Kenji Wada-Isoe, Hisanori Kowa, Kenji Nakashima
BACKGROUND: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is sometimes confused with Parkinson's disease, multiple system atrophy, and other disorders. The typical clinical features are categorized as Richardson's syndrome (RS), but other clinical subtypes include PSP-parkinsonism (PSP-P) and PSP-pure akinesia with gait freezing (PSP-PAGF). In this study, we determined the prevalence of PSP in a Japanese rural area compared to our previous 1999 report. METHODS: We collected data in Yonago City from 2009 to 2014 using a service-based study of PSP...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28009063/lesions-causing-freezing-of-gait-localize-to-a-cerebellar-functional-network
#11
Alfonso Fasano, Simon E Laganiere, Susy Lam, Michael D Fox
OBJECTIVE: Freezing of gait is a disabling symptom in Parkinson disease and related disorders, but the brain regions involved in symptom generation remain unclear. Here we analyze brain lesions causing acute onset freezing of gait to identify regions causally involved in symptom generation. METHODS: Fourteen cases of lesion-induced freezing of gait were identified from the literature, and lesions were mapped to a common brain atlas. Because lesion-induced symptoms can come from sites connected to the lesion location, not just the lesion location itself, we also identified brain regions functionally connected to each lesion location...
January 2017: Annals of Neurology
https://www.readbyqxmd.com/read/27956066/the-clinical-significance-of-freezing-while-turning-in-parkinson-s-disease
#12
Martina Mancini, Katrijn Smulders, Rajal G Cohen, Fay B Horak, Nir Giladi, John G Nutt
Freezing of gait (FoG) in people with Parkinson's disease (PD) is an environmentally sensitive, intermittent problem that occurs most often during turning. FoG is difficult for clinicians to evaluate and treat because it can be difficult to elicit during a clinical visit. Here, we aimed to develop a clinically valid objective measure of freezing severity during a 2-min 360-degree turning-in-place. Twenty-eight subjects with PD (16 freezers, FoG+, and 12 nonfreezers, FoG-) in the "off" state and 14 healthy control subjects were tested...
February 20, 2017: Neuroscience
https://www.readbyqxmd.com/read/27939113/effects-of-auditory-cues-on-gait-initiation-and-turning-in-patients-with-parkinson-s-disease
#13
J Gómez-González, P Martín-Casas, R Cano-de-la-Cuerda
OBJECTIVE: To review the available scientific evidence about the effectiveness of auditory cues during gait initiation and turning in patients with Parkinson's disease. METHODS: We conducted a literature search in the following databases: Brain, PubMed, Medline, CINAHL, Scopus, Science Direct, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Library Plus, CENTRAL, Trip Database, PEDro, DARE, OTseeker, and Google Scholar. We included all studies published between 2007 and 2016 and evaluating the influence of auditory cues on independent gait initiation and turning in patients with Parkinson's disease...
December 8, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27915226/subthalamic-nucleus-stimulation-and-gait-in-parkinson-s-disease-a-not-always-fruitful-relationship
#14
REVIEW
Giovanni Cossu, Massimiliano Pau
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) provides efficient treatment for the alleviation of motor signs in patients with advanced Parkinson's disease (PD), but its specific effects on gait is sometimes less successful as it may even lead to an aggravation of freezing of gait. To better understand when axial symptoms can be expected to improve and when they may worsen or be resistant to STN-DBS, we propose here a narrative review that considers the recent literature evidences based on instrumental gait analysis data...
November 27, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27899223/-test-d-%C3%A3-valuation-des-membres-sup%C3%A3-rieurs-des-personnes-%C3%A3-g%C3%A3-es-%C3%A2-tempa-to-assess-upper-limb-activity-in-parkinson-s-disease
#15
Paula Ruiz de Freitas, Ana Elisa Lemos, Mariana Palla Santos, Stella Maris Michaelsen, Clynton Lourenço Corrêa, Alessandra Swarowsky
STUDY DESIGN: Cross-sectional and observational study. PURPOSE OF THE STUDY: Assess upper limb (UL) activity limitations using the "Test d'Evaluation des Membres Supérieurs Des Personnes Agées" (TEMPA) in individuals with Parkinson's disease (PD) and verify its clinimetrics properties. METHODS: The following were evaluated: internal consistency, interrater and test-retest reliability; concurrent validity; convergent validity; know group's validity; minimal detectable change, floor and ceiling effects, and the relationship between UL activity limitations and the presence of freezing of gait...
November 26, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27878377/relationship-between-the-plasma-levels-of-neurodegenerative-proteins-and-motor-subtypes-of-parkinson-s-disease
#16
Jian Ding, Jiejin Zhang, Xixi Wang, Li Zhang, Siming Jiang, Yongsheng Yuan, Junyi Li, Lin Zhu, Kezhong Zhang
The aim of our study is to examine the plasma levels of the four kinds of neurodegenerative proteins in plasma: α-syn, T-tau, P-tau181, and Aβ-42 in Parkinson's disease (PD) and to evaluate the relationship between their plasma levels and PD motor subtypes. 84 patients with PD were enrolled in our study, and finally, 73 of them were classified into the tremor-dominant subtype (TD) and the postural instability gait difficulty subtype (PIGD). Their motor performance was evaluated by a series of clinical assessments: Freezing of Gait Questionnaire (FOGQ), Timed Up and Go (TUGs), Tinetti balance, and Tinetti gait...
November 22, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27872585/the-pedunculopontine-tegmental-nucleus-as-a-motor-and-cognitive-interface-between-the-cerebellum-and-basal-ganglia
#17
REVIEW
Fumika Mori, Ken-Ichi Okada, Taishin Nomura, Yasushi Kobayashi
As an important component of ascending activating systems, brainstem cholinergic neurons in the pedunculopontine tegmental nucleus (PPTg) are involved in the regulation of motor control (locomotion, posture and gaze) and cognitive processes (attention, learning and memory). The PPTg is highly interconnected with several regions of the basal ganglia, and one of its key functions is to regulate and relay activity from the basal ganglia. Together, they have been implicated in the motor control system (such as voluntary movement initiation or inhibition), and modulate aspects of executive function (such as motivation)...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27862267/spinal-cord-stimulation-improves-gait-in-patients-with-parkinson-s-disease-previously-treated-with-deep-brain-stimulation
#18
Carolina Pinto de Souza, Clement Hamani, Carolina Oliveira Souza, William Omar Lopez Contreras, Maria Gabriela Dos Santos Ghilardi, Rubens Gisbert Cury, Egberto Reis Barbosa, Manoel Jacobsen Teixeira, Erich Talamoni Fonoff
BACKGROUND: Deep brain stimulation and levodopatherapy ameliorate motor manifestations in Parkinson's disease, but their effects on axial signs are not sustained in the long term. OBJECTIVES: The objective of this study was to investigate the safety and efficacy of spinal cord stimulation on gait disturbance in advanced Parkinson's disease. METHODS: A total of 4 Parkinson's disease patients who experienced significant postural instability and gait disturbance years after chronic subthalamic stimulation were treated with spinal cord stimulation at 300 Hz...
November 10, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27823571/caffeine-the-forgotten-potential-for-parkinson-s-disease
#19
Ahmed Negida, Mohamed Elfil, Attia Attia, Eslam Farahat, Mohamed Gabr, Ahmed Essam, Hussein Ahmed, Doaa Attia
Parkinson's disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies. The literature suggests that caffeine play multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk of developing PD, especially in genetically susceptible patients. On the level of Lewy bodies' formation, caffeine binds to α-synuclein protein inducing conformational changes and preventing their aggregation...
November 6, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27778161/brain-plasticity-in-parkinson-s-disease-with-freezing-of-gait-induced-by-action-observation-training
#20
Federica Agosta, Roberto Gatti, Elisabetta Sarasso, Maria Antonietta Volonté, Elisa Canu, Alessandro Meani, Lidia Sarro, Massimiliano Copetti, Erik Cattrysse, Eric Kerckhofs, Giancarlo Comi, Andrea Falini, Massimo Filippi
Gait disorders represent a therapeutic challenge in Parkinson's disease (PD). This study investigated the efficacy of 4-week action observation training (AOT) on disease severity, freezing of gait and motor abilities in PD, and evaluated treatment-related brain functional changes. 25 PD patients with freezing of gait were randomized into two groups: AOT (action observation combined with practicing the observed actions) and "Landscape" (same physical training combined with landscape-videos observation). At baseline and 4-week, patients underwent clinical evaluation and fMRI...
January 2017: Journal of Neurology
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