keyword
MENU ▼
Read by QxMD icon Read
search

Freeze of Gait in Parkinson's disease

keyword
https://www.readbyqxmd.com/read/28892573/bicycling-suppresses-abnormal-beta-synchrony-in-the-parkinsonian-basal-ganglia
#1
Lena Storzer, Markus Butz, Jan Hirschmann, Omid Abbasi, Maciej Gratkowski, Dietmar Saupe, Jan Vesper, Sarang S Dalal, Alfons Schnitzler
OBJECTIVE: Freezing of gait is a poorly understood symptom of Parkinson's disease, and can severely disrupt the locomotion of affected patients. However, bicycling ability remains surprisingly unaffected in most patients suffering from freezing suggesting functional differences in the motor network. The purpose of this study was to characterize and contrast the oscillatory dynamics underlying bicycling and walking in the basal ganglia. METHODS: We present the first local field potential recordings directly comparing bicycling and walking in Parkinson's disease patients with electrodes implanted in the subthalamic nuclei for deep brain stimulation...
September 11, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28890341/cueing-for-people-with-parkinson-s-disease-with-freezing-of-gait-a-narrative-review-of-the-state-of-the-art-and-novel-perspectives
#2
REVIEW
Ginis Pieter, Nackaerts Evelien, Nieuwboer Alice, Heremans Elke
Freezing, which manifests during gait and other movements, is an incapacitating motor symptom experienced by many patients with Parkinson's disease (PD). In rehabilitation, auditory and visual cueing methods are commonly applied to evoke a more goal-directed type of motor control and, as such, reduce freezing severity in patients with PD. In this narrative review, we summarize the current evidence regarding the effects of external cueing in patients with PD with freezing of gait (FOG) and provide suggestions on how to further improve cueing effectiveness with emerging technological developments...
September 7, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28890315/subthalamic-neural-entropy-is-a-feature-of-freezing-of-gait-in-freely-moving-people-with-parkinson-s-disease
#3
Judy Syrkin-Nikolau, Mandy Miller Koop, Thomas Prieto, Chioma Anidi, Muhammad Furqan Afzal, Anca Velisar, Zack Blumenfeld, Talora Martin, Megan Trager, Helen Bronte-Stewart
The goal of this study was to investigate subthalamic (STN) neural features of Freezers and Non-Freezers with Parkinson's disease (PD), while freely walking without freezing of gait (FOG) and during periods of FOG, which were better elicited during a novel turning and barrier gait task than during forward walking. METHODS: Synchronous STN local field potentials (LFPs), shank angular velocities, and ground reaction forces were measured in fourteen PD subjects (eight Freezers) off medication, OFF deep brain stimulation (DBS), using an investigative, implanted, sensing neurostimulator (Activa® PC+S, Medtronic, Inc...
September 7, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28886015/freezing-during-tapping-tasks-in-patients-with-advanced-parkinson-s-disease-and-freezing-of-gait
#4
Arnaud Delval, Luc Defebvre, Céline Tard
INTRODUCTION: Parkinson's disease patients with freezing of gait also experience sudden motor blocks (freezing) during other repetitive motor tasks. We assessed the proportion of patients with advanced PD and freezing of gait who also displayed segmental "freezing" in tapping tasks. METHODS: Fifteen Parkinson's disease patients with freezing of gait were assessed. Freezing of gait was evaluated using a standardized gait trajectory with the usual triggers. Patients performed repetitive tapping movements (as described in the MDS-UPDRS task) with the hands or the feet in the presence or absence of a metronome set to 4 Hz...
2017: PloS One
https://www.readbyqxmd.com/read/28858631/near-falls-in-people-with-parkinson-s-disease-circumstances-contributing-factors-and-association-with-falling
#5
Tatjana Gazibara, Darija Kisic Tepavcevic, Marina Svetel, Aleksandra Tomic, Iva Stankovic, Vladimir S Kostic, Tatjana Pekmezovic
OBJECTIVES: To describe circumstances of near-falls among persons with Parkinson's disease (PD), assess factors associated with near-falling and assess whether near-falls in the first 6 months are associated with falling in the latter 6 months over one year of follow-up. MATERIALS AND METHODS: In the period August 2011-December 2012, 120 consecutive persons with PD, who denied having fallen in the past 6 months, were recruited at Clinical center of Serbia in Belgrade...
October 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28855889/l-dopa-and-freezing-of-gait-in-parkinson-s-disease-objective-assessment-through-a-wearable-wireless-system
#6
Antonio Suppa, Ardian Kita, Giorgio Leodori, Alessandro Zampogna, Ettore Nicolini, Paolo Lorenzi, Rosario Rao, Fernanda Irrera
Freezing of gait (FOG) is a leading cause of falls and fractures in Parkinson's disease (PD). The episodic and rather unpredictable occurrence of FOG, coupled with the variable response to l-DOPA of this gait disorder, makes the objective evaluation of FOG severity a major clinical challenge in the therapeutic management of patients with PD. The aim of this study was to examine and compare gait, clinically and objectively, in patients with PD, with and without FOG, by means of a new wearable system. We also assessed the effect of l-DOPA on FOG severity and specific spatiotemporal gait parameters in patients with and without FOG...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28855887/identification-of-characteristic-motor-patterns-preceding-freezing-of-gait-in-parkinson-s-disease-using-wearable-sensors
#7
Luca Palmerini, Laura Rocchi, Sinziana Mazilu, Eran Gazit, Jeffrey M Hausdorff, Lorenzo Chiari
Freezing of gait (FOG) is a disabling symptom that is common among patients with advanced Parkinson's disease (PD). External cues such as rhythmic auditory stimulation can help PD patients experiencing freezing to resume walking. Wearable systems for automatic freezing detection have been recently developed. However, these systems detect a FOG episode after it has happened. Instead, in this study, a new approach for the prediction of FOG (before it actually happens) is presented. Prediction of FOG might enable preventive cueing, reducing the likelihood that FOG will occur...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28852579/predictors-of-functional-and-quality-of-life-outcomes-following-deep-brain-stimulation-surgery-in-parkinson-s-disease-patients-disease-patient-and-surgical-factors
#8
Hesham Abboud, Gencer Genc, Nicolas R Thompson, Srivadee Oravivattanakul, Faisal Alsallom, Dennys Reyes, Kathy Wilson, Russell Cerejo, Xin Xin Yu, Darlene Floden, Anwar Ahmed, Michal Gostkowski, Ayman Ezzeldin, Hazem Marouf, Ossama Y Mansour, Andre Machado, Hubert H Fernandez
OBJECTIVE: The primary objective was to evaluate predictors of quality of life (QOL) and functional outcomes following deep brain stimulation (DBS) in Parkinson's disease (PD) patients. The secondary objective was to identify predictors of global improvement. METHODS: PD patients who underwent DBS at our Center from 2006 to 2011 were evaluated by chart review and email/phone survey. Postoperative UPDRS II and EQ-5D were analyzed using simple linear regression adjusting for preoperative score...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28837826/botulinum-toxin-in-parkinsonism-the-when-how-and-which-for-botulinum-toxin-injections
#9
Francisco Cardoso
The aim of this article is to provide a review of the use of injections of botulinum toxin in the management of selected symptoms and signs of Parkinson's disease and other forms of parkinsonism. Sialorrhea is defined as inability to control oral secretions, resulting in excessive saliva in the oropharynx. There is a high level of evidence for the treatment of sialorrhea in parkinsonism with injections of different forms of botulinum toxin type A as well as botulinum toxin type B. Tremor can be improved by the use of botulinum toxin injections but improved tremor control often leads to concomitant motor weakness, limiting its use...
August 23, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28830666/depression-may-negatively-affect-the-change-in-freezing-of-gait-following-subthalamic-nucleus-stimulation-in-parkinson-s-disease
#10
Ryul Kim, Han-Joon Kim, Aryun Kim, Yoon Kim, Ah-Ro Kim, Chae-Won Shin, Sun Ha Paek, Beomseok Jeon
OBJECTIVE: To assess the influence of preoperative depression on the change in freezing of gait (FOG) following subthalamic nucleus stimulation (STN-DBS) in patients with Parkinson's disease (PD). METHODS: One hundred and twelve PD patients were included who received bilateral STN-DBS. Of these, 33 had no preoperative depression (PD-ND) and the other 79 had preoperative depression (PD-D). Each PD-ND patient was matched with one PD-D patient by the propensity score for which sex, age at PD onset, disease duration, UPDRS-III score during off-medication state, levodopa-equivalent daily dose, and mini mental state examination were the independent variables...
August 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28829978/spatial-constraints-evoke-increased-number-of-steps-during-turning-in-parkinson-s-disease
#11
Urban M Fietzek, Lisa Stuhlinger, Annika Plate, Andres Ceballos-Baumann, Kai Bötzel
OBJECTIVE: Turning and limitations to step length were shown to trigger progressive shortening of steps, which can lead to freezing of gait. By reducing the base area in which the turn had to take place, we aimed to evaluate the contribution of spatial constraints on 360° axial turns in people with Parkinson's disease with and without freezing. METHODS: We evaluated 40 patients with and without freezing and 16 age-matched healthy subjects. We assessed clinical data, and used body-worn inertial sensors to describe stepping and turn duration of 360° in quadratic squares of different sizes marked on the floor...
July 25, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28803956/selective-cholinergic-depletion-of-pedunculopontine-tegmental-nucleus-aggravates-freezing-of-gait-in-parkinsonian-rats
#12
Hu Xiao, Min Li, Junbin Cai, Nanxiang Li, Ming Zhou, Peng Wen, Zhengyuan Xie, Qiang Wang, Jingyu Chang, Wangming Zhang
Many patients of advanced Parkinson's disease (PD) suffer from intractable axial symptoms (severe gait and postural impairments), which were recently speculated to be more relevant to cholinergic degeneration in the brainstem than dopaminergic degeneration in the substantia nigra compacta (SNc). To investigate the role of the cholinergic cells of the pedunculopontine tegmental nucleus (PPTg) on motor deficits, especially the axial motor impairments, we measured and analyzed the gait performance of sham lesion rats, SNc dopaminergic lesion rats, PPTg cholinergic lesion rats, and combined lesion rats by using the CatWalk system...
August 10, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28790972/investigation-of-anticipatory-postural-adjustments-during-one-leg-stance-using-inertial-sensors-evidence-from-subjects-with-parkinsonism
#13
Gianluca Bonora, Martina Mancini, Ilaria Carpinella, Lorenzo Chiari, Maurizio Ferrarin, John G Nutt, Fay B Horak
The One-Leg Stance (OLS) test is a widely adopted tool for the clinical assessment of balance in the elderly and in subjects with neurological disorders. It was previously showed that the ability to control anticipatory postural adjustments (APAs) prior to lifting one leg is significantly impaired by idiopathic Parkinson's disease (iPD). However, it is not known how APAs are affected by other types of parkinsonism, such as frontal gait disorders (FGD). In this study, an instrumented OLS test based on wearable inertial sensors is proposed to investigate both the initial anticipatory phase and the subsequent unipedal balance...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28702192/freezing-of-gait-is-an-early-clinical-feature-of-progressive-supranuclear-palsy
#14
Yasushi Osaki, Yukari Morita, Yuka Miyamoto, Kounosuke Furuta, Hirokazu Furuya
BACKGROUND AND AIM: Early clinical diagnosis of progressive supranuclear palsy (PSP) remains challenging. AIM: We attempted to identify any sign or symptom to diagnose PSP earlier. METHODS: A total of 401 patients, 40 with PSP and 361 with other neurodegenerative disorders, were included. We followed these patients for at least 1 year since 2009. We reviewed the signs and symptoms of patients with PSP in a standardized manner, and observed four manifestations: "vertical supranuclear gaze abnormality," "movement disorders," "pseudobulbar palsy" and "dementia of frontal type...
May 2017: Neurology and Clinical Neuroscience
https://www.readbyqxmd.com/read/28698150/freezing-of-gait-is-associated-with-cognitive-impairment-in-patients-with-parkinson-disease
#15
Zhiwen Yao, Yuan Shao, Xiang Han
OBJECTIVE: To explore whether the cognitive impairment is correlated with freezing of gait (FOG) in patients with Parkinson disease (PD). METHODS: A total of 186 patients with Parkinson disease (104 patients with FOG and 82 patients with no clinical history of freezing behavior) and 125 healthy individuals were selected for this study. Neuropsychological assessments, including the scales for outcomes in Parkinson disease cognition, unified Parkinson's disease rating scale, and Hamilton depression/anxiety rating scale etc...
July 8, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28673611/effects-of-curved-walking-training-on-curved-walking-performance-and-freezing-of-gait-in-individuals-with-parkinson-s-disease-a-randomized-controlled-trial
#16
Fang-Yu Cheng, Yea-Ru Yang, Yih-Ru Wu, Shih-Jung Cheng, Ray-Yau Wang
INTRODUCTION: The purpose of this study was to investigate the effects of curved-walking training (CWT) on curved-walking performance and freezing of gait (FOG) in people with Parkinson's disease (PD). METHODS: Twenty-four PD subjects were recruited and randomly assigned to the CWT group or control exercise (CE) group and received 12 sessions of either CWT with a turning-based treadmill or general exercise training for 30 min followed by 10 min of over-ground walking in each session for 4-6 weeks...
June 28, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28659862/usability-of-three-dimensional-augmented-visual-cues-delivered-by-smart-glasses-on-freezing-of-gait-in-parkinson-s-disease
#17
Sabine Janssen, Benjamin Bolte, Jorik Nonnekes, Marian Bittner, Bastiaan R Bloem, Tjitske Heida, Yan Zhao, Richard J A van Wezel
External cueing is a potentially effective strategy to reduce freezing of gait (FOG) in persons with Parkinson's disease (PD). Case reports suggest that three-dimensional (3D) cues might be more effective in reducing FOG than two-dimensional cues. We investigate the usability of 3D augmented reality visual cues delivered by smart glasses in comparison to conventional 3D transverse bars on the floor and auditory cueing via a metronome in reducing FOG and improving gait parameters. In laboratory experiments, 25 persons with PD and FOG performed walking tasks while wearing custom-made smart glasses under five conditions, at the end-of-dose...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28653213/external-input-for-gait-in-people-with-parkinson-s-disease-with-and-without-freezing-of-gait-one-size-does-not-fit-all
#18
Pieter Ginis, Elke Heremans, Alberto Ferrari, Esther M J Bekkers, Colleen G Canning, Alice Nieuwboer
Cueing or feedback provided when gait deviates from a predefined goal (intelligent input) can now be provided with wearable technology for Parkinson's disease (PD). As people with and without freezing of gait (FOG) have distinct cognitive profiles, they may respond differently to various types of input. This study compared the effects of four input modalities during prolonged walking and explored the relationship with cognition, subjective preference, and FOG. Participants (15 with and 13 without FOG) walked 30 min while exposed to continuous cueing; intelligent cueing; intelligent feedback; or no input...
July 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28634343/falling-direction-can-predict-the-mechanism-of-recurrent-falls-in-advanced-parkinson-s-disease
#19
Jinyoung Youn, Yasuyuki Okuma, Minho Hwang, Dongyeop Kim, Jin Whan Cho
Falls are a common and disabling symptom in patients with Parkinson's disease (PD). For prevention, it is important to understand the pathophysiology of falls in PD patients, but the predictors for the possible mechanisms underlying such falls have not been clearly elucidated. In this prospective observational study, we investigated the implications of falling direction to predict the mechanisms of recurrent falls in PD patients. We enrolled 62 recurrent fallers with PD and divided them into two groups according to the main falling directions: 45 PD fallers who fell forward (forward fallers), and 17 PD fallers who fell in the other directions (non-forward fallers)...
June 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629269/aquatic-obstacle-training-improves-freezing-of-gait-in-parkinson-s-disease-patients-a-randomized-controlled-trial
#20
Zhizhong Zhu, Miaomiao Yin, Liling Cui, Ying Zhang, Weijia Hou, Yaqing Li, Hua Zhao
OBJECTIVE: Our aim was to evaluate the effect of aquatic obstacle training on balance parameters in comparison with a traditional aquatic therapy in patients with Parkinson's disease. DESIGN: A randomized single-blind controlled trial. SETTING: Outpatients in the rehabilitation department. SUBJECTS: A total of 46 patients with Parkinson's disease in Hoehn-Yahr stage 2-3. INTERVENTIONS: Participants were randomly assigned to (1) aquatic therapy or (2) obstacle aquatic therapy...
June 1, 2017: Clinical Rehabilitation
keyword
keyword
117979
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"