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Freeze of Gait in Parkinson's disease

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https://www.readbyqxmd.com/read/28088380/aquatic-exercise-therapy-for-people-with-parkinson-s-disease-a-randomized-controlled-trial
#1
Louise M Carroll, Daniele Volpe, Meg E Morris, Jean Saunders, Amanda M Clifford
OBJECTIVE: To evaluate the effects of aquatic exercise therapy on gait variability and disability compared to usual care for people with Parkinson's disease (PD). DESIGN: Single-blind randomized control trial (RCT). SETTING: A community based hydrotherapy pool in Ireland. PARTICIPANTS: Twenty one individuals with PD (Hoehn-Yahr Stages I-III). INTERVENTIONS: Participants were randomly assigned to either an aquatic exercise therapy group (45 minutes, twice a week for 6 weeks) or a control group that received usual care...
January 11, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28031995/prevalence-of-progressive-supranuclear-palsy-in-yonago-change-throughout-a-decade
#2
Hiroshi Takigawa, Michio Kitayama, Kenji Wada-Isoe, Hisanori Kowa, Kenji Nakashima
BACKGROUND: Progressive supranuclear palsy (PSP) is a neurodegenerative disorder that is sometimes confused with Parkinson's disease, multiple system atrophy, and other disorders. The typical clinical features are categorized as Richardson's syndrome (RS), but other clinical subtypes include PSP-parkinsonism (PSP-P) and PSP-pure akinesia with gait freezing (PSP-PAGF). In this study, we determined the prevalence of PSP in a Japanese rural area compared to our previous 1999 report. METHODS: We collected data in Yonago City from 2009 to 2014 using a service-based study of PSP...
December 2016: Brain and Behavior
https://www.readbyqxmd.com/read/28009063/lesions-causing-freezing-of-gait-localize-to-a-cerebellar-functional-network
#3
Alfonso Fasano, Simon E Laganiere, Susy Lam, Michael D Fox
OBJECTIVE: Freezing of gait is a disabling symptom in Parkinson's disease and related disorders, but the brain regions involved in symptom generation remain unclear. Here we analyze brain lesions causing acute onset freezing of gait to identify regions causally involved in symptom generation. METHODS: Fourteen cases of lesion-induced freezing of gait were identified from the literature and lesions were mapped to a common brain atlas. Because lesion-induced symptoms can come from sites connected to the lesion location, not just the lesion location itself, we also identified brain regions functionally connected to each lesion location...
December 23, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/27956066/the-clinical-significance-of-freezing-while-turning-in-parkinson-s-disease
#4
Martina Mancini, Katrijn Smulders, Rajal G Cohen, Fay B Horak, Nir Giladi, John G Nutt
Freezing of gait (FoG) in people with Parkinson's disease (PD) is an environmentally sensitive, intermittent problem that occurs most often during turning. FoG is difficult for clinicians to evaluate and treat because it can be difficult to elicit during a clinical visit. Here, we aimed to develop a clinically valid objective measure of freezing severity during a 2-min 360-degree turning-in-place. Twenty-eight subjects with PD (16 freezers, FoG+, and 12 nonfreezers, FoG-) in the "off" state and 14 healthy control subjects were tested...
December 9, 2016: Neuroscience
https://www.readbyqxmd.com/read/27939113/effects-of-auditory-cues-on-gait-initiation-and-turning-in-patients-with-parkinson-s-disease
#5
J Gómez-González, P Martín-Casas, R Cano-de-la-Cuerda
OBJECTIVE: To review the available scientific evidence about the effectiveness of auditory cues during gait initiation and turning in patients with Parkinson's disease. METHODS: We conducted a literature search in the following databases: Brain, PubMed, Medline, CINAHL, Scopus, Science Direct, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Library Plus, CENTRAL, Trip Database, PEDro, DARE, OTseeker, and Google Scholar. We included all studies published between 2007 and 2016 and evaluating the influence of auditory cues on independent gait initiation and turning in patients with Parkinson's disease...
December 8, 2016: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/27915226/subthalamic-nucleus-stimulation-and-gait-in-parkinson-s-disease-a-not-always-fruitful-relationship
#6
REVIEW
Giovanni Cossu, Massimiliano Pau
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) provides efficient treatment for the alleviation of motor signs in patients with advanced Parkinson's disease (PD), but its specific effects on gait is sometimes less successful as it may even lead to an aggravation of freezing of gait. To better understand when axial symptoms can be expected to improve and when they may worsen or be resistant to STN-DBS, we propose here a narrative review that considers the recent literature evidences based on instrumental gait analysis data...
November 27, 2016: Gait & Posture
https://www.readbyqxmd.com/read/27899223/-test-d-%C3%A3-valuation-des-membres-sup%C3%A3-rieurs-des-personnes-%C3%A3-g%C3%A3-es-%C3%A2-tempa-to-assess-upper-limb-activity-in-parkinson-s-disease
#7
Paula Ruiz de Freitas, Ana Elisa Lemos, Mariana Palla Santos, Stella Maris Michaelsen, Clynton Lourenço Corrêa, Alessandra Swarowsky
STUDY DESIGN: Cross-sectional and observational study. PURPOSE OF THE STUDY: Assess upper limb (UL) activity limitations using the "Test d'Evaluation des Membres Supérieurs Des Personnes Agées" (TEMPA) in individuals with Parkinson's disease (PD) and verify its clinimetrics properties. METHODS: The following were evaluated: internal consistency, interrater and test-retest reliability; concurrent validity; convergent validity; know group's validity; minimal detectable change, floor and ceiling effects, and the relationship between UL activity limitations and the presence of freezing of gait...
November 26, 2016: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/27878377/relationship-between-the-plasma-levels-of-neurodegenerative-proteins-and-motor-subtypes-of-parkinson-s-disease
#8
Jian Ding, Jiejin Zhang, Xixi Wang, Li Zhang, Siming Jiang, Yongsheng Yuan, Junyi Li, Lin Zhu, Kezhong Zhang
The aim of our study is to examine the plasma levels of the four kinds of neurodegenerative proteins in plasma: α-syn, T-tau, P-tau181, and Aβ-42 in Parkinson's disease (PD) and to evaluate the relationship between their plasma levels and PD motor subtypes. 84 patients with PD were enrolled in our study, and finally, 73 of them were classified into the tremor-dominant subtype (TD) and the postural instability gait difficulty subtype (PIGD). Their motor performance was evaluated by a series of clinical assessments: Freezing of Gait Questionnaire (FOGQ), Timed Up and Go (TUGs), Tinetti balance, and Tinetti gait...
November 22, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27872585/the-pedunculopontine-tegmental-nucleus-as-a-motor-and-cognitive-interface-between-the-cerebellum-and-basal-ganglia
#9
REVIEW
Fumika Mori, Ken-Ichi Okada, Taishin Nomura, Yasushi Kobayashi
As an important component of ascending activating systems, brainstem cholinergic neurons in the pedunculopontine tegmental nucleus (PPTg) are involved in the regulation of motor control (locomotion, posture and gaze) and cognitive processes (attention, learning and memory). The PPTg is highly interconnected with several regions of the basal ganglia, and one of its key functions is to regulate and relay activity from the basal ganglia. Together, they have been implicated in the motor control system (such as voluntary movement initiation or inhibition), and modulate aspects of executive function (such as motivation)...
2016: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/27862267/spinal-cord-stimulation-improves-gait-in-patients-with-parkinson-s-disease-previously-treated-with-deep-brain-stimulation
#10
Carolina Pinto de Souza, Clement Hamani, Carolina Oliveira Souza, William Omar Lopez Contreras, Maria Gabriela Dos Santos Ghilardi, Rubens Gisbert Cury, Egberto Reis Barbosa, Manoel Jacobsen Teixeira, Erich Talamoni Fonoff
BACKGROUND: Deep brain stimulation and levodopatherapy ameliorate motor manifestations in Parkinson's disease, but their effects on axial signs are not sustained in the long term. OBJECTIVES: The objective of this study was to investigate the safety and efficacy of spinal cord stimulation on gait disturbance in advanced Parkinson's disease. METHODS: A total of 4 Parkinson's disease patients who experienced significant postural instability and gait disturbance years after chronic subthalamic stimulation were treated with spinal cord stimulation at 300 Hz...
November 10, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27823571/caffeine-the-forgotten-potential-for-parkinson-s-disease
#11
Ahmed Negida, Mohamed Elfil, Attia Attia, Eslam Farahat, Mohamed Gabr, Ahmed Essam, Hussein Ahmed, Doaa Attia
Parkinson's disease (PD) is the second most common neurological disorder characterized by loss of dopaminergic fibers in the basal ganglia and presence of Lewy bodies. The literature suggests that caffeine play multiple roles in PD. Epidemiological studies showed that caffeine intake was associated with less risk of developing PD, especially in genetically susceptible patients. On the level of Lewy bodies' formation, caffeine binds to α-synuclein protein inducing conformational changes and preventing their aggregation...
November 6, 2016: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/27778161/brain-plasticity-in-parkinson-s-disease-with-freezing-of-gait-induced-by-action-observation-training
#12
Federica Agosta, Roberto Gatti, Elisabetta Sarasso, Maria Antonietta Volonté, Elisa Canu, Alessandro Meani, Lidia Sarro, Massimiliano Copetti, Erik Cattrysse, Eric Kerckhofs, Giancarlo Comi, Andrea Falini, Massimo Filippi
Gait disorders represent a therapeutic challenge in Parkinson's disease (PD). This study investigated the efficacy of 4-week action observation training (AOT) on disease severity, freezing of gait and motor abilities in PD, and evaluated treatment-related brain functional changes. 25 PD patients with freezing of gait were randomized into two groups: AOT (action observation combined with practicing the observed actions) and "Landscape" (same physical training combined with landscape-videos observation). At baseline and 4-week, patients underwent clinical evaluation and fMRI...
October 24, 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27766724/effect-of-high-frequency-subthalamic-neurostimulation-on-gait-and-freezing-of-gait-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#13
REVIEW
C Schlenstedt, A Shalash, M Muthuraman, D Falk, K Witt, G Deuschl
The aim of this meta-analysis was to summarize the short- and long-term effects of bilateral deep brain stimulation of the subthalamic nucleus (STN-DBS) on gait and freezing of gait (FOG) in Parkinson's disease and to detect predictors of post-stimulation outcome. A comprehensive review of the literature was conducted up to October 2015 using Medline Ovid databases for studies analyzing the effect of bilateral STN-DBS on FOG and/or gait. Sixteen studies with available data for the gait item (no. 29) of the Unified Parkinson's Disease Rating Scale (UPDRS) and six studies with the FOG item (no...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27765426/diffusion-alterations-associated-with-parkinson-s-disease-symptomatology-a-review-of-the-literature
#14
REVIEW
Julie M Hall, Kaylena A Ehgoetz Martens, Courtney C Walton, Claire O'Callaghan, Peter E Keller, Simon J G Lewis, Ahmed A Moustafa
Parkinson's disease (PD) is a heterogeneous neurological disorder with a variety of motor and non-motor symptoms. The underlying mechanisms of these symptoms are not fully understood. An increased interest in structural connectivity analyses using diffusion tensor imaging (DTI) in PD has led to an expansion of our understanding of the impact of abnormalities in diffusivity on phenotype. This review outlines the contribution of these abnormalities to symptoms of PD including bradykinesia, tremor and non-tremor phenotypes, freezing of gait, cognitive impairment, mood, sleep disturbances, visual hallucinations and olfactory dysfunction...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27747983/volumetric-analysis-of-the-cerebellum-in-patients-with-progressive-supranuclear-palsy
#15
Y Lee, D K Lee, J M Lee, S J Chung, J J Lee, Y H Sohn, P H Lee
BACKGROUND AND PURPOSE: Although early cerebellar symptoms are one of the exclusive criteria in the diagnosis of progressive supranuclear palsy (PSP), cerebellar involvement in PSP is evident both clinically and pathologically. However, structural analysis focusing on the cerebellum has not been previously studied in patients with PSP. We aimed to evaluate cerebellar involvement in PSP using a magnetic resonance imaging-based segmental volumetric analysis. METHODS: We retrospectively enrolled 48 patients with PSP composed of 25 patients with PSP-Richardson's syndrome (RS) and 23 patients with pure akinesia with gait freezing, 39 patients with Parkinson's disease (PD) and 34 healthy controls...
January 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/27725534/transdermal-patch-of-rotigotine-attenuates-freezing-of-gait-in-patients-with-parkinson-s-disease-an-open-label-comparative-study-of-three-non-ergot-dopamine-receptor-agonists
#16
Ken Ikeda, Takehisa Hirayama, Takanori Takazawa, Kiyokazu Kawabe, Yasuo Iwasaki
Objective Parkinson's disease (PD) is characterized by the progressive degeneration of the nigrostriatal dopaminergic neurons. Rotigotine is a non-ergot dopamine receptor agonist (DA). Its transdermal patch maintains the effective concentrations for 24 hours. Freezing of gait (FOG) is a common and devastating symptom in PD patients. Little is known about therapeutic effects of rotigotine on FOG in PD patients. Herein we compared how three non-ergot DAs of rotigotine, pramipexole LA and ropinirole CR influence FOG, besides classical motor deficits in PD patients...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27723878/subregional-pattern-of-striatal-dopamine-transporter-loss-on-18f-fp-cit-positron-emission-tomography-in-patients-with-pure-akinesia-with-gait-freezing
#17
Sangwon Han, Minyoung Oh, Jungsu S Oh, Sang Ju Lee, Seung Jun Oh, Sun Ju Chung, Hee Kyung Park, Jae Seung Kim
Importance: Pure akinesia with gait freezing (PAGF) is a clinical syndrome characterized by freezing of gait, handwriting, and speech without abnormal eye movement or cognitive impairment. Several studies have suggested that PAGF may be a variant of progressive supranuclear palsy (PSP). However, the characteristics of striatal dopamine transporter loss in PAGF are unknown. Objective: To investigate the subregional pattern of striatal dopamine transporter loss in patients with PAGF in comparison with patients with PSP and those with Parkinson disease (PD)...
December 1, 2016: JAMA Neurology
https://www.readbyqxmd.com/read/27723662/pedunculopontine-nucleus-region-deep-brain-stimulation-in-parkinson-disease-surgical-anatomy-and-terminology
#18
Clement Hamani, Tipu Aziz, Bastiaan R Bloem, Peter Brown, Stephan Chabardes, Terry Coyne, Kelly Foote, Edgar Garcia-Rill, Etienne C Hirsch, Andres M Lozano, Paolo A M Mazzone, Michael S Okun, William Hutchison, Peter Silburn, Ludvic Zrinzo, Mesbah Alam, Laurent Goetz, Erlick Pereira, Anand Rughani, Wesley Thevathasan, Elena Moro, Joachim K Krauss
Several lines of evidence over the last few years have been important in ascertaining that the pedunculopontine nucleus (PPN) region could be considered as a potential target for deep brain stimulation (DBS) to treat freezing and other problems as part of a spectrum of gait disorders in Parkinson disease and other akinetic movement disorders. Since the introduction of PPN DBS, a variety of clinical studies have been published. Most indicate improvements in freezing and falls in patients who are severely affected by these problems...
2016: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/27670977/effect-of-cumulative-repetitive-transcranial-magnetic-stimulation-on-freezing-of-gait-in-patients-with-atypical-parkinsonism-a-pilot-study
#19
RANDOMIZED CONTROLLED TRIAL
Won Hyuk Chang, Min Su Kim, Jin Whan Cho, Jinyoung Youn, Yun Kwan Kim, Sun Woong Kim, Ahee Lee, Yun-Hee Kim
OBJECTIVE: To investigate the potential of cumulative high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on freezing of gait in atypical Parkinsonism. DESIGN: Randomized, single-blinded, crossover study with a blinded observer. PARTICIPANTS: Eight patients with atypical Parkinsonism. METHODS: All participants received HF-rTMS over the lower leg primary motor cortex (M1-LL) for 5 consecutive days. Alternative sham stimulation was also administered with a 2-week wash-out period...
October 12, 2016: Journal of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27662331/the-practicalities-of-assessing-freezing-of%C3%A2-gait
#20
Claudia Barthel, Elizabeth Mallia, Bettina Debû, Bastiaan R Bloem, Murielle Ursulla Ferraye
BACKGROUND: Freezing of gait (FOG) is a mysterious, complex and debilitating phenomenon in Parkinson's disease. Adequate assessment is a pre-requisite for managing FOG, as well as for assigning participants in FOG research. The episodic nature of FOG, as well as its multiple clinical expressions make its assessment challenging. OBJECTIVE: To highlight the available assessment tools and to provide practical, experience-based recommendations for reliable assessment of FOG...
October 19, 2016: Journal of Parkinson's Disease
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