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Hip fracture in adults

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https://www.readbyqxmd.com/read/28225746/atypical-antipsychotics-and-the-risk-of-falls-and-fractures-among-older-adults-an-emulation-analysis-and-an-evaluation-of-additional-confounding-control-strategies
#1
Darmendra Ramcharran, Hong Qiu, Martijn J Schuemie, Patrick B Ryan
PURPOSE: The aim of this study was to investigate the risk of falls and fractures among older adults receiving atypical antipsychotics. METHODS: An emulation analysis of a previously published study was performed using the US Truven MarketScan Medicare Supplemental database (MDCR). In addition, modified analyses were implemented to evaluate alternative confounding control strategies that (1) included all covariates used to fit propensity score models in outcome models and (2) required patients to have a mental health condition diagnosis and a health care visit within 90 days prior to the index date...
April 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28205299/perioperative-hypothermia-during-hip-fracture-surgery-an-observational-study
#2
Usha Gurunathan, Christopher Stonell, Paul Fulbrook
RATIONALE: Elderly patients are at high risk of accidental perioperative hypothermia. The primary objective of this study was to measure the changes in body temperature and the incidence of hypothermia in elderly patients undergoing hip fracture surgery. METHODS: We conducted a prospective observational study on all adult patients undergoing surgery for fractured neck of femur between December 2013 and July 2014. We monitored their temperatures in different perioperative areas at multiple time points and also noted the warming methods used...
February 16, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28181695/later-age-at-onset-of-independent-walking-is-associated-with-lower-bone-strength-at-fracture-prone-sites-in-older-men
#3
Alex Ireland, Stella Muthuri, Joern Rittweger, Judith E Adams, Kate A Ward, Diana Kuh, Rachel Cooper
Later age at onset of independent walking is associated with lower leg bone strength in childhood and adolescence. However it is unknown whether these associations persist into older age, or whether they are evident at axial (central) or upper limb sites. Therefore we examined walking age obtained at 2y and bone outcomes obtained by dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT) scans at 60-64y in a nationally-representative cohort study of British people, the MRC National Survey of Health and Development...
February 9, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28154941/the-association-between-sarcopenia-and-functional-outcomes-among-older-patients-with-hip-fracture-undergoing-in-hospital-rehabilitation
#4
F Landi, R Calvani, E Ortolani, S Salini, A M Martone, L Santoro, A Santoliquido, A Sisto, A Picca, E Marzetti
: This study evaluates the prevalence of sarcopenia among older people admitted to a rehabilitation unit after hip fracture and the association between sarcopenia and functional outcomes. The results show that sarcopenia had a negative impact on functional recovery. The assessment of sarcopenia among older adults receiving rehabilitation programs is crucial. INTRODUCTION: Sarcopenia is a highly prevalent geriatric syndrome associated with adverse outcomes, including falls, disability, institutionalization, and mortality...
February 2, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28150034/association-of-dpp-4-activity-with-bmd-body-composition-and-incident-hip-fracture-the-cardiovascular-health-study
#5
L D Carbone, P Bůžková, H A Fink, J A Robbins, M Bethel, C M Isales, W D Hill
: There was no association of plasma DPP-4 activity levels with bone mineral density (BMD), body composition, or incident hip fractures in a cohort of elderly community-dwelling adults. INTRODUCTION: Dipeptidyl peptidase IV (DPP-4) inactivates several key hormones including those that stimulate postprandial insulin secretion, and DPP-4 inhibitors (gliptins) are approved to treat diabetes. While DPP-4 is known to modulate osteogenesis, the relationship between DPP-4 activity and skeletal health is uncertain...
February 2, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28130572/long-term-effects-of-neridronate-in-adults-with-osteogenesis-imperfecta-an-observational-three-year-italian-study
#6
O Viapiana, L Idolazzi, A Fassio, G Orsolini, M Rossini, G Adami, F Bertoldo, D Gatti
The aim of this study was to assess the long-term efficacy and safety of i.v. neridronate in the treatment of osteogenesis imperfecta (OI). One hundred and fourteen patients affected by OI were included in the study. Neridronate was administered by i.v. infusion at the dosage of 2 mg/kg, up to a maximum of 100 mg at three-month intervals for 3 years. Dual X-ray absorptiometry of the lumbar spine, hip, and ultradistal and proximal radius were evaluated every 6 months. Blood calcium, phosphate, albumin, fasting urinary calcium/creatinine ratio, total serum alkaline phosphatase, and bone alkaline phosphatase were obtained at baseline and every 3 months...
January 27, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28127147/bullet-fragment-induced-lead-arthropathy-with-subsequent-fracture-and-elevated-blood-lead-levels
#7
Scott A McAninch, Jonathan Adkison, Ridgely Meyers, Michael Benham
Lead foreign bodies in joint spaces, often due to projectiles such as bullets, may cause localized arthropathy. There are no reports of joint fracture related to lead arthropathy. Additionally, lead foreign bodes embedded in the joint space may be a source of systemic lead absorption, causing elevated blood lead levels and toxicity to other organs. We present a young adult patient with retained left hip joint bullet fragments who developed suspected lead arthropathy and subsequent acute left hip fracture, as well as systemic lead absorption demonstrated by elevated blood lead levels...
January 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28122506/variation-in-use-of-antipsychotic-medications-in-nursing-homes-in-the-united-states-a-systematic-review
#8
Hannah Cioltan, Samah Alshehri, Carol Howe, Jeannie Lee, Mindy Fain, Howard Eng, Kenneth Schachter, Jane Mohler
BACKGROUND: The use of antipsychotic medications (APMs) in nursing home residents in the U.S. is an increasingly prominent issue and has been associated with increased risk of hospitalization, cardiovascular events, hip fractures, and mortality, among other adverse health events. The Food and Drug Administration has placed a black box warning on these drugs, specifying that they are not meant for residents with dementia, and has asked providers to review their treatment plans. The purpose of this systematic PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses)-based review was to summarize original research studies on facility level characteristics contributing to the use of antipsychotics in nursing homes across the United States, in order to investigate the variation of use...
January 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28122396/predictors-of-postoperative-falls-in-the-first-and-second-postoperative-years-among-elderly-hip-fracture-patients
#9
Hsiang-Fen Yeh, Jung-Hua Shao, Chia-Lin Li, Chi-Chuan Wu, Yea-Ing L Shyu
AIM AND OBJECTIVES: To explore risk factors for a single fall and multiple falls in the first and second postoperative years among older people hip fracture patients. BACKGROUND: Older people hip fracture patients have a high probability of falling again after a fall incident. Risk factors for postoperative falls among older people hip fracture patients in Taiwan remain to be confirmed. DESIGN: Secondary analysis. METHODS: Data collected from control groups of two clinical trials conducted during 2001-2004 and during 2005-2009 were selected...
January 25, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28118983/twelve-month-work-related-outcomes-following-hip-fracture-in-patients-under-65-years-of-age
#10
Christina L Ekegren, Elton R Edwards, Andrew Oppy, Susan Liew, Richard Page, Richard de Steiger, Peter A Cameron, Andrew Bucknill, Raphael Hau, Belinda J Gabbe
INTRODUCTION: Recent research has highlighted the need for improved outcome reporting in younger hip fracture patients. For this population, return to work (RTW) is a particularly important measure against which to evaluate treatment outcomes. However, to date, only two small studies have reported RTW outcomes in young hip fracture patients and neither investigated factors predictive of RTW. The aims of this study were to report return to work (RTW) status and predictors of RTW 12 months after hip fracture in patients <65 years...
January 18, 2017: Injury
https://www.readbyqxmd.com/read/28111239/benefits-and-harms-of-atypical-antipsychotics-for-agitation-in-adults-with-dementia
#11
REVIEW
Martin R Farlow, Tatyana A Shamliyan
We evaluated the most current evidence regarding the benefits and harms of atypical antipsychotics in adults with dementia. In June 2016, following a protocol developed a priori, we systematically searched several databases for published and unpublished data from randomized controlled trials (RCT), observational studies, and meta-analyses; conducted direct meta-analyses using a random effects model; and graded the quality of evidence according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group...
January 19, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28102457/prevalence-of-vertebral-fracture-and-densitometric-osteoporosis-in-spanish-adult-men-the-camargo-cohort-study
#12
José M Olmos, José L Hernández, Josefina Martínez, Emilio Pariente, Jesús Castillo, Daniel Prieto-Alhambra, Jesús González-Macías
The aim of this study was to assess the prevalence of densitometric osteoporosis and vertebral fractures in Spanish men aged ≥50 years, and to study how the relationship between them may change depending on how osteoporosis is diagnosed. A community-based population of 1003 men aged ≥50 years was studied. Bone mineral density (BMD) was measured by DXA at the lumbar spine, femoral neck and total hip. Vertebral fractures were assessed by lateral thoracic and lumbar spine radiographs. The prevalence of osteoporosis was estimated with both the World Health Organization (WHO) (T-score of <-2...
January 19, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28073948/functioning-and-health-related-quality-of-life-following-injury-in-older-people-a-systematic-review
#13
Katherine Brown, Ian D Cameron, Lisa Keay, Kristy Coxon, Rebecca Ivers
AIM AND BACKGROUND: There is growing evidence around the impact of injury and recovery trajectories but little focuses on older people, despite rising burden. The aim of this review was to describe the evidence for postinjury functioning and health-related quality of life (HRQoL) in older people. METHOD: A systematic search of three databases and an extensive search of the grey literature was carried out on prospective injury outcome studies in older people (age ≥65 years) that used a generic health status outcome measure...
January 10, 2017: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/28070457/the-concurrent-validity-and-reliability-of-the-leg-motion-system-for-measuring-ankle-dorsiflexion-range-of-motion-in-older-adults
#14
Carlos Romero Morales, César Calvo Lobo, David Rodríguez Sanz, Irene Sanz Corbalán, Beatriz Ruiz Ruiz, Daniel López López
BACKGROUND: New reliable devices for range of motion (ROM) measures in older adults are necessary to improve knowledge about the functional capability in this population. Dorsiflexion ROM limitation is associated with ankle injuries, foot pain, lower limb disorders, loss of balance, gait control disorders and fall risk in older adults. The aim of the present study was to assess the validity and reliability of the Leg Motion device for measuring ankle dorsiflexion ROM in older adults. METHODS: Adescriptive repeated-measures study was designed to test the reliability of Leg Motion in thirty-three healthy elderly patients older than 65 years...
2017: PeerJ
https://www.readbyqxmd.com/read/28068425/predictive-factors-for-pressure-ulcers-in-an-older-adult-population-hospitalized-for-hip-fractures-a-prognostic-cohort-study
#15
Paolo Chiari, Cristiana Forni, Monica Guberti, Domenica Gazineo, Sabrina Ronzoni, Fabio D'Alessandro
BACKGROUND: Older adult patients with fragility hip fractures constitute a population at high risk for complications, in particular pressure ulcers. The aim was to evaluate the incidence of pressure ulcers and potential predictive factors. METHODS AND FINDINGS: A prospective multicentric prognostic cohort study in orthopedic wards in three Italian public hospitals. Participants were all consecutive patients 65 years of age or older diagnosed with a fragility hip fracture...
2017: PloS One
https://www.readbyqxmd.com/read/28065626/choosing-a-femoral-head-a-survey-study-of-academic-adult-reconstructive-surgeons
#16
Sumon Nandi, Matthew S Austin
BACKGROUND: Our aim was to examine how academic adult reconstructive surgeons have interpreted evidence on femoral head material in total hip arthroplasty (THA). METHODS: A 16-question survey to evaluate attitudes toward ceramic and cobalt-chrome head use was emailed to 274 faculty at 42 US adult reconstruction fellowship programs. RESULTS: With 116 respondents, the response rate was 42.2%. Faculty use ceramic heads 72.9% of the time. The most common reason why respondents do not use ceramic heads is cost (44...
December 18, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28043896/marrow-adipose-tissue-composition-in-adults-with-morbid-obesity
#17
Elaine W Yu, Logan Greenblatt, Alireza Eajazi, Martin Torriani, Miriam A Bredella
Patients with type 2 diabetes mellitus (T2DM) have increased fracture risk despite normal or increased bone mineral density (BMD). Elevations in marrow adipose tissue (MAT) and declines in MAT unsaturation are both associated with increased skeletal fragility. The objective of our study was to characterize the quantity and composition of MAT in adults with morbid obesity and T2DM, and to evaluate determinants of MAT. We studied 21 adults with morbid obesity prior to bariatric surgery, 8 of whom had T2DM. All subjects underwent 1H-MR spectroscopy of the lumbar spine and femur for assessment of MAT and dual-energy x-ray absorptiometry (DXA) and quantitative computed tomography (QCT) of the lumbar spine and hip for assessment of areal BMD (aBMD) and volumetric BMD (vBMD)...
December 30, 2016: Bone
https://www.readbyqxmd.com/read/28041872/use-of-dual-energy-x-ray-absorptiometry-dxa-for-diagnosis-and-fracture-risk-assessment-who-criteria-t-and-z-score-and-reference-databases
#18
Hans P Dimai
Dual-energy X-ray absorptiometry (DXA) is a two-dimensional imaging technology developed to assess bone mineral density (BMD) of the entire human skeleton and also specifically of skeletal sites known to be most vulnerable to fracture. In order to simplify interpretation of BMD measurement results and allow comparability among different DXA-devices, the T-score concept was introduced. This concept involves an individual's BMD which is then compared with the mean value of a young healthy reference population, with the difference expressed as a standard deviation (SD)...
December 29, 2016: Bone
https://www.readbyqxmd.com/read/28031021/the-efficacy-of-treadmill-training-with-and-without-projected-visual-context-for-improving-walking-ability-and-reducing-fall-incidence-and-fear-of-falling-in-older-adults-with-fall-related-hip-fracture-a-randomized-controlled-trial
#19
Mariëlle W van Ooijen, Melvyn Roerdink, Marga Trekop, Thomas W J Janssen, Peter J Beek
BACKGROUND: The ability to adjust walking to environmental context is often reduced in older adults and, partly as result of this, falls are common in this population. A treadmill with visual context projected on its belt (e.g., obstacles and targets) allows for practicing step adjustments relative to that context, while concurrently exploiting the great amount of walking practice associated with conventional treadmill training. The present study was conducted to compare the efficacy of adaptability treadmill training, conventional treadmill training and usual physical therapy in improving walking ability and reducing fear of falling and fall incidence in older adults during rehabilitation from a fall-related hip fracture...
December 28, 2016: BMC Geriatrics
https://www.readbyqxmd.com/read/28026203/sexual-dimorphism-in-bone-muscle-relationship-in-young-adults
#20
Vera Zymbal, Kathleen F Janz, Fátima Baptista
The purpose of this study was to analyse associations between lean soft tissue (LST), a surrogate of skeletal muscle mass and key fracture-related geometric characteristics of the proximal femur. Moreover, we examined the role that muscle played on the proximal femur geometry in response to physical activity (PA). Participants were 83 young adults. Leg LST (exposure) was assessed by dual energy X-ray absorptiometry (DXA). Proximal femur geometry was derived from a left hip DXA scan. Geometric variables (outcomes) included the femoral neck axis length (FNAL), the femoral neck width (FNW), the neck-shaft angle and FNW|FNAL (an index of robustness)...
December 27, 2016: Journal of Sports Sciences
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