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Autoimmune thyroid

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https://www.readbyqxmd.com/read/28716436/frontal-fibrosing-alopecia-among-men-a%C3%A2-clinicopathologic-study-of-7-cases
#1
Stanislav N Tolkachjov, Hafsa M Chaudhry, Michael J Camilleri, Rochelle R Torgerson
BACKGROUND: Frontal fibrosing alopecia (FFA) is a lichen planopilaris-variant scarring alopecia that has rarely been described in men. OBJECTIVE: To characterize the clinicopathologic findings of FFA in men by studying a series of 7 male patients. METHODS: We conducted a retrospective review of all cases of male patients with FFA at the Mayo Clinic from 1992 to 2016. RESULTS: Seven male patients with FFA were identified...
July 14, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28712818/systemic-lupus-erythematosus-and-thyroid-disease-experience-in-a-single-medical-center-in-taiwan
#2
Yu-Chuan Liu, Wen-Ya Lin, Ming-Chin Tsai, Lin-Shien Fu
BACKGROUND: To investigate the association of systemic lupus erythematosus (SLE) with thyroid diseases in a medical center in central Taiwan. METHODS: This is a retrospective cohort of 2796 SLE patients in a tertiary referral medical center from 2000 to 2013. We screened SLE by catastrophic illness registration from national insurance bureau; and thyroid diseases by ICD 9 codes, then confirmed by thyroid function test, auto-antibody, medical and/or surgical intervention...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28710237/focal-neurological-presentation-in-hashimoto-s-encephalopathy-mimicking-a-vascular-occlusion-of-the-middle-cerebral-artery
#3
Ahmad Alazzeh, Sarah Jaroudi, Matthew Gooch, Alan N Peiris
Hashimoto's encephalopathy is a rare form of autoimmune encephalopathy. It is likely an underdiagnosed entity especially in the setting of focal neurological defects. We report a case of a 49-year-old man who presented with "strange behavior"of a day's duration. Examination was significant only for lethargy, poor attention span and agitation. Routine labs revealed leucocytosis. Head CT scan was unremarkable. Lumbar puncture showed high white blood cells with lymphocytosis and elevated protein level. The patient was empirically treated for meningitis without improvement...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28710200/thyrotoxicosis-in-patients-with-hypothyroidism-is-not-just-overtreatment
#4
Punith Kempegowda, Ananth U Nayak
A 62-year-old Caucasian woman presented with hypothyroid symptoms and biochemical thyrotoxic picture. Previously, she underwent right-sided subtotal thyroidectomy and left partial thyroid lobectomy for thyroid lumps, and treated with thyroxine replacement for hypothyroidism. Although there were no significant findings on clinical examination, investigations confirmed thyrotoxicosis with positive autoimmunity against thyroid glandâ€"all in line with a diagnosis of Graves’ hyperthyroidism. We would like to highlight atypical presentations of thyroid dysfunction and conversion of underactive to overactive thyroid status with this case...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28706507/epigenetics-and-autoimmune-thyroid-diseases
#5
REVIEW
Fabio Coppedè
Increasing evidence suggests that epigenetic modifications, including changes in DNA methylation, covalent modifications of histone tails, and gene silencing mediated by non-coding RNA molecules, play a substantial role in the pathogenesis of autoimmune disorders and might be seen as the result of environmental insults that trigger these conditions. Studies in cells and tissues of patients with autoimmune thyroid diseases (AITD), and particularly in Graves' disease (GD) and Hashimoto's thyroiditis (HT), are increasingly revealing altered epigenetic marks and resultant deregulation of gene expression levels, but the available data are still limited to be translated into the clinical settings...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28704192/risk-factors-for-postpartum-thyroid-dysfunction-in-euthyroid-women-prior-to-pregnancy
#6
Boyan I Nonchev, Antoaneta V Argatska, Blagovest K Pehlivanov, Maria M Orbetzova
BACKGROUND: Thyroid dysfunction is common during the postpartum and the predisposing factors for its development are considered specific for the population studied. The aim of this study was to evaluate the risk factors for the occurrence of postpartum thyroid dysfunction (PPTD) in euthyroid women prior to pregnancy. MATERIALS AND METHODS: Forty-five women with PPTD and 55 age-matched euthyroid postpartum women from Plovdiv, Bulgaria were included in the study. TSH, FT4, FT3, TPOAb, TgAb, TRAb were measured and ultrasound evaluation of the thyroid was performed in the first trimester of pregnancy and during the postpartum...
June 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28701998/thyroid-autoimmunity-and-lichen
#7
REVIEW
Fabrizio Guarneri, Roberta Giuffrida, Flavia Di Bari, Serafinella Patrizia Cannavò, Salvatore Benvenga
Lichen planus (LP) and lichen sclerosus (LS) are cutaneous-mucous diseases with uncertain epidemiology. Current data, which are likely to be underestimated, suggest a prevalence in the general population of 0.1-4% for cutaneous LP, 1.27-2.0% for oral LP, and 0.1-3.3% for LS. While etiology of lichen is still unknown, clinical and histological evidence show an (auto)immune pathogenesis. Association of lichen with autoimmune thyroid disease (AITD) has been investigated in few studies. This association appears better defined in the case of LS, while is more controversial for LP...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28698095/circulating-cxcl10-is-increased-in-non-segmental-vitiligo-in-presence-or-absence-of-autoimmune-thyroiditis
#8
REVIEW
Silvia Martina Ferrari, Poupak Fallahi, Giulia Santaguida, Camilla Virili, Ilaria Ruffilli, Francesca Ragusa, Marco Centanni, Alessandro Antonelli
Recently the importance of CXCL10 in the pathogenesis of non-segmental vitiligo (NSV) and autoimmune thyroid disorders (AITD) has been shown. No data are present about chemokines CXCL10 (Th1 prototype) and CCL2 (Th2 prototype) circulating levels in NSV patients with/without thyroiditis (AT). Serum CXCL10 and CCL2 have been measured in 50 consecutive NSV patients, in 40 consecutive patients with NSV and AT (NSV+AT), in 50 sex- and age-matched controls without AT (control 1) and in 40 sex- and age-matched patients with AT without NSV (control 2)...
July 8, 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28695870/deranged-regulatory-t-cells-and-transforming-growth-factor-%C3%AE-1-levels-in-type-1-diabetes-patients-with-associated-autoimmune-diseases
#9
N Kaur, R W Minz, S K Bhadada, D Dayal, J Singh, S Anand
AIM: This study was designed to enumerate regulatory T-cells (Tregs) and estimate transforming growth factor-β1 (TGF-β1) levels in type 1 diabetic (T1D) patients with respect to disease duration and associated autoimmune diseases. METHODS: One hundred and fifty patients and twenty healthy controls were recruited in the study. The patients were subcategorized into eight categories on the basis of disease duration (new onset [NO] and long standing [LS]) and associated diseases, i...
July 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28693124/pediatric-toxic-polycystic-thyroid
#10
Janeil M Belle, Nektarios Vasilottos, Todd D Nebesio, Benjamin C James
BACKGROUND: Polycystic thyroid disease (PCTD) is a rare condition and has been described in adults in the setting of subclinical and clinical hypothyroidism. We present the first known case of a pediatric patient with diffuse macrocystic degeneration of the thyroid. CLINICAL PRESENTATION: A 6-year-old previously healthy patient was evaluated after presenting with a 16-month history of an enlarging polycystic thyroid and hyperthyroidism. Markers of autoimmune thyroid disease including thyroid stimulating immunoglobulin (TSI), thyroid stimulating hormone (TSH) receptor antibody, thyroid peroxidase antibody and thyroglobulin antibody were negative...
June 16, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28693118/high-prevalence-of-organ-specific-autoantibodies-in-indian-type-1-diabetic-patients
#11
Shivaprasad Channabasappa, Anish Kolly, Annie Pulikkal, K M Prasanna Kumar
BACKGROUND: Type 1 diabetes (T1D) is frequently associated with other autoimmune conditions such as autoimmune thyroiditis, coeliac disease (CD) and Addison's disease. There are sparse data on the prevalence of antibodies against these conditions in Indian patients with T1D. This study aims to evaluate prevalence of these T1D associated autoantibodies in Indian patients. METHODS: Two hundred and fifty-eight patients with T1D were recruited from the Bangalore Diabetes Hospital and the Vydehi Institute of Medical Sciences and Research Centre (VIMS) for the study...
June 23, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28692781/depression-as-a-risk-factor-of-organic-diseases-an-international-integrative-review
#12
Teodora Bica, Ruth Castelló, Loren L Toussaint, Pilar Montesó-Curto
PURPOSE AND DESIGN: This integrative review offers a systematic synthesis of the international literature regarding the role of depression as a risk factor in physical illnesses and the mechanisms of this connection. Special attention is paid to those modifiable factors. FINDINGS: Published studies of depression and physical illness and disease(N = 24) from five countries that were indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycNET, Scopus, Dialnet, and CUIDEN were examined...
July 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28690889/imbalances-in-t-cell-related-transcription-factors-among-patients-with-hashimoto-s-thyroiditis
#13
Vahid Safdari, Ebrahim Alijani, Maryam Nemati, Abdollah Jafarzadeh
OBJECTIVES: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto's thyroiditis (HT). Differentiation of effector T helper (Th) 1, Th2, Th17 and regulatory T cell (Treg) lymphocytes is regulated by transcription factors, including Th1-specific T box (T-bet), GATA binding protein-3 (GATA3), retinoid-related orphan receptor (ROR)-α and forkhead box P3 (FOXP3). This study aimed to investigate Th1/Th2, Th1/Treg, Th2/Treg and Th17/Treg balances at the level of these transcription factors...
May 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28689782/the-microbiota-and-autoimmunity-their-role-in-thyroid-autoimmune-diseases
#14
REVIEW
Hedda L Köhling, Sue F Plummer, Julian R Marchesi, Kelly S Davidge, Marian Ludgate
Since the 1970s, the role of infectious diseases in the pathogenesis of Graves' disease (GD) has been an object of intensive research. The last decade has witnessed many studies on Yersinia enterocolitica, Helicobacter pylori and other bacterial organisms and their potential impact on GD. Retrospective, prospective and molecular binding studies have been performed with contrary outcomes. Until now it is not clear whether bacterial infections can trigger autoimmune thyroid disease. Common risk factors for GD (gender, smoking, stress, and pregnancy) reveal profound changes in the bacterial communities of the gut compared to that of healthy controls but a pathogenetic link between GD and dysbiosis has not yet been fully elucidated...
July 6, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28689597/other-extrahepatic-manifestations-of-hepatitis-c-virus-infection-pulmonary-idiopathic-thrombocytopenic-purpura-nondiabetes-endocrine-disorders
#15
REVIEW
Daniel Segna, Jean-François Dufour
Extrahepatic manifestations of hepatitis C virus (HCV) infection are a rare but serious condition. This article summarizes the current literature on the association between HCV and endocrine and pulmonary manifestations, as well as idiopathic thrombocytopenic purpura (ITP). HCV may directly infect extrahepatic tissues and interact with the immune system predisposing for obstructive and interstitial lung disease, ITP, autoimmune thyroiditis, infertility, growth hormone and adrenal deficiencies, osteoporosis, and potentially lung and thyroid cancers...
August 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28687188/-oral-and-dental-expression-of-thyroid-diseases
#16
Jean-Louis Wémeau, Christine Do Cao, Miriam Ladsous
Oral disorders were observed in children with congenital hypothyroidism, lately apparent because of difficulties of feeding, swallowing disorders, and macroglossia. Macroglossia was also a component of the severe acquired myxedema, particularly observed in hypothyroidism related to autoimmune atrophic thyroiditis beyond menopause. Lingual ectopy in children and adults could determine respiratory gene or swallowing difficulties, and were detectable by visual examination and the endobuccal touch. Expression of these events was completely minimized since the neonatal screening of congenital hypothyroidism, also by the common practice in adults of serum TSH determinations...
July 4, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28683860/latent-hypothyroidism-in-adults
#17
Jeannine Schübel, Joachim Feldkamp, Antje Bergmann, Wolfgang Drossard, Karen Voigt
BACKGROUND: The prevalence of latent/subclinical hypothyroidism is between 3% and 10%, according to epidemiologic studies that have been carried out in the USA, the United Kingdom, and Denmark. As persons with latent hypo - thyroidism are often asymptomatic, the diagnosis is often made incidentally in routine laboratory testing. METHODS: This review is based on a selective search in PubMed for publications on the diagnosis and treatment of latent hypothyroidism...
June 23, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28680307/thyroid-function-and-ultrasonography-abnormalities-in-lithium-treated-bipolar-patients-a-cross-sectional-study-with-healthy-controls
#18
Özlem Kuman Tunçel, Fisun Akdeniz, Süha Süreyya Özbek, Gülgün Kavukçu, Gökçen Ünal Kocabaş
INTRODUCTION: Lithium has many effects on thyroid physiology. Although these side effects have been known for a long time, large sample studies of lithium-treated patients using ultrasonography are lacking. The aim of this study is to investigate the detailed thyroid morphologies, hormone levels, and antibodies of lithium-treated patients compared with healthy controls. METHODS: This cross-sectional study involved 84 lithium-treated patients with bipolar disorder and 65 gender and age similar controls who had never been exposed to lithium...
June 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28678538/what-they-don-t-see
#19
Cody M Clemens
The author is currently living with a chronic autoimmune disease known as Hashimoto's Thyroiditis, which caused his hypothyroidism. Although this disease is most common in middle-aged women, he was diagnosed at age 23. This disease is unique, because it is not entirely visible to others. In this piece, he presents a personal narrative of his diagnosis process and utilizes poetic inquiry to demonstrate to readers what "they," meaning individuals without an invisible chronic autoimmune disease, don't see.
July 5, 2017: Health Communication
https://www.readbyqxmd.com/read/28675712/association-of-the-polymorphisms-in-the-gene-encoding-thyroglobulin-with-the-development-and-prognosis-of-autoimmune-thyroid-disease
#20
Tomoyo Mizuma, Mikio Watanabe, Naoya Inoue, Yuya Arakawa, Saki Tomari, Yoh Hidaka, Yoshinori Iwatani
Graves' disease (GD) and Hashimoto's disease (HD) are autoimmune thyroid diseases (AITDs), and the prognosis of AITDs is different for each patient. We examined the association of polymorphisms in the Thyroglobulin (TG) gene with the pathogenesis of AITD. We genotyped TG rs180195G/A, rs853326G/A, rs2076740C/T, rs2703013G/T, rs2958692C/T and rs733735A/G polymorphisms in 137 HD patients, 131 GD patients and 89 healthy controls and also examined the levels of TG mRNA expression and serum TG. The TG rs180195 GG genotype was more frequent in HD patients (p = ...
July 4, 2017: Autoimmunity
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