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https://www.readbyqxmd.com/read/29147950/mental-health-consultation-among-ontario-s-immigrant-populations
#1
Farah Islam, Nazilla Khanlou, Alison Macpherson, Hala Tamim
To determine the prevalence rates and characteristics of past-year mental health consultation for Ontario's adult (18 + years old) immigrant populations. The Canadian Community Health Survey (CCHS) 2012 was used to calculate the prevalence rates of past-year mental health consultation by service provider type. Characteristics associated with mental health consultation were determined by carrying out multivariable logistic regression analysis on merged CCHS 2008-2012 data. Adult immigrant populations in Ontario (n = 3995) had lower estimated prevalence rates of past-year mental health consultation across all service provider types compared to Canadian-born populations (n = 14,644)...
November 16, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29133784/gyri-like-proteins-catalyze-cyclopropanoid-hydrolysis-to-confer-cellular-protection
#2
Hua Yuan, Jinru Zhang, Yujuan Cai, Sheng Wu, Kui Yang, H C Stephen Chan, Wei Huang, Wen-Bing Jin, Yan Li, Yue Yin, Yasuhiro Igarashi, Shuguang Yuan, Jiahai Zhou, Gong-Li Tang
GyrI-like proteins are widely distributed in prokaryotes and eukaryotes, and recognized as small-molecule binding proteins. Here, we identify a subfamily of these proteins as cyclopropanoid cyclopropyl hydrolases (CCHs) that can catalyze the hydrolysis of the potent DNA-alkylating agents yatakemycin (YTM) and CC-1065. Co-crystallography and molecular dynamics simulation analyses reveal that these CCHs share a conserved aromatic cage for the hydrolytic activity. Subsequent cytotoxic assays confirm that CCHs are able to protect cells against YTM...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29098737/structural-and-functional-differences-in-phox2b-frameshift-mutations-underlie-isolated-or-syndromic-congenital-central-hypoventilation-syndrome
#3
Simona Di Lascio, Roberta Benfante, Eleonora Di Zanni, Silvia Cardani, Annalisa Adamo, Diego Fornasari, Isabella Ceccherini, Tiziana Bachetti
Heterozygous mutations in the PHOX2B gene are causative of Congenital Central Hypoventilation Syndrome (CCHS), a neurocristopathy characterised by defective autonomic control of breathing due to the impaired differentiation of neural crest cells (NCCs). Among PHOX2B mutations, polyalanine (polyAla) expansions are almost exclusively associated with isolated CCHS, whereas frameshift variants, although less frequent, are often more severe than polyAla expansions and identified in syndromic CCHS. This paper provides a complete review of all the frameshift mutations identified in cases of isolated and syndromic CCHS reported in the literature as well as those identified by us and not yet published...
November 2, 2017: Human Mutation
https://www.readbyqxmd.com/read/29092135/key-on-demand-kod-for-software-defined-optical-networks-secured-by-quantum-key-distribution-qkd
#4
Yuan Cao, Yongli Zhao, Carlos Colman-Meixner, Xiaosong Yu, Jie Zhang
Software-defined optical networking (SDON) will become the next generation optical network architecture. However, the optical layer and control layer of SDON are vulnerable to cyberattacks. While, data encryption is an effective method to minimize the negative effects of cyberattacks, secure key interchange is its major challenge which can be addressed by the quantum key distribution (QKD) technique. Hence, in this paper we discuss the integration of QKD with WDM optical networks to secure the SDON architecture by introducing a novel key on demand (KoD) scheme which is enabled by a novel routing, wavelength and key assignment (RWKA) algorithm...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29070641/dementia-population-risk-tool-demport-study-protocol-for-a-predictive-algorithm-assessing-dementia-risk-in-the-community
#5
Stacey Fisher, Amy Hsu, Nassim Mojaverian, Monica Taljaard, Gregory Huyer, Douglas G Manuel, Peter Tanuseputro
INTRODUCTION: The burden of disease from dementia is a growing global concern as incidence increases dramatically with age, and average life expectancy has been increasing around the world. Planning for an ageing population requires reliable projections of dementia prevalence; however, existing population projections are simple and have poor predictive accuracy. The Dementia Population Risk Tool (DemPoRT) will predict incidence of dementia in the population setting using multivariable modelling techniques and will be used to project dementia prevalence...
October 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28992836/carbamazepine-improves-apneic-episodes-in-congenital-central-hypoventilation-syndrome-cchs-with-a-novel-phox2b-exon-1-missense-mutation
#6
Schaida Schirwani, Karen Pysden, Philip Chetcuti, Moira Blyth
No abstract text is available yet for this article.
October 4, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28930364/nutritional-risk-hospitalization-and-mortality-among-community-dwelling-canadians-aged-65-or-older
#7
Pamela L Ramage-Morin, Heather Gilmour, Michelle Rotermann
BACKGROUND: Nutritional risk has been associated with various negative health outcomes among older people. Limited longitudinal research has examined the relationship between nutritional risk and hospitalization and death in community-dwelling older people. DATA AND METHODS: Data from the 2008/2009 Canadian Community Health Survey-Healthy Aging (CCHS-HA) linked to the Discharge Abstract Database and the Canadian Mortality Database were used to estimate the prevalence of nutritional risk among seniors and examine its relationship with acute care hospitalization and death during the 25- to 36-month period following the CCHS-HA interview...
September 20, 2017: Health Reports
https://www.readbyqxmd.com/read/28910259/estimation-of-smoking-prevalence-in-canada-implications-of-survey-characteristics-in-the-cchs-and-ctums-ctads
#8
Thierry Gagné
One of the main enterprises associated with tobacco control is surveillance, that is, to measure and follow over time the extent of smoking among the Canadian population. While surveillance systems have been in place for more than 50 years, knowing the exact prevalence of smoking in Canada continues to be a complex matter and understanding its estimation requires a critical appreciation of our national surveys' idiosyncrasies. This commentary describes the two Statistics Canada surveys that are most commonly used to examine smoking prevalence in this country: the Canadian Community Health Survey (CCHS) and the Canadian Tobacco, Alcohol and Drugs Survey (CTADS)...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28910244/inequalities-in-oral-health-understanding-the-contributions-of-education-and-income
#9
Julie Farmer, Rebecca C Phillips, Sonica Singhal, Carlos Quiñonez
OBJECTIVE: To quantify the extent to which income and education explain gradients in oral health outcomes. METHODS: Using data from the Canadian Community Health Survey (CCHS 2003), binary logistic regression models were constructed to examine the relationship between income and education on self-reported oral health (SROH) and chewing difficulties (CD) while controlling for age, sex, ethnicity, employment status and dental insurance coverage. The relative index of inequality (RII) was utilized to quantify the extent to which income and education explain gradients in poor SROH and CD...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28861609/mir-375-and-yap1-expression-profiling-in-medullary-thyroid-carcinoma-and-their-correlation-with-clinical-pathological-features-and-outcome
#10
Francesca Galuppini, Loris Bertazza, Susi Barollo, Elisabetta Cavedon, Massimo Rugge, Vincenza Guzzardo, Diana Sacchi, Sara Watutantrige-Fernando, Federica Vianello, Caterina Mian, Gianmaria Pennelli
Medullary thyroid cancer (MTC) is a tumor marked by an indolent growth for which few prognostic factors and therapeutic strategies are actually available. Different studies have recently appraised well-differentiated thyroid cancers are characterized by a dysregulation in different microRNA sets; however, only few of them investigated the role of miRNA expression in MTCs. In this study, we have assessed the miR-375 expression in a series of 130 MTCs (104 are sporadic and 26 familial) with a median follow-up of 39 months (range 1-138) and then we have correlated our results with the clinical-pathological features and the patients' outcome...
November 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28847012/accuracy-of-cardiovascular-risk-prediction-varies-by-neighborhood-socioeconomic-position-a-retrospective-cohort-study
#11
Jarrod E Dalton, Adam T Perzynski, David A Zidar, Michael B Rothberg, Claudia J Coulton, Alex T Milinovich, Douglas Einstadter, James K Karichu, Neal V Dawson
Background: Inequality in health outcomes in relation to Americans' socioeconomic position is rising. Objective: First, to evaluate the spatial relationship between neighborhood disadvantage and major atherosclerotic cardiovascular disease (ASCVD)-related events; second, to evaluate the relative extent to which neighborhood disadvantage and physiologic risk account for neighborhood-level variation in ASCVD event rates. Design: Observational cohort analysis of geocoded longitudinal electronic health records...
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28800279/more-than-a-feeling-an-empirical-analysis-of-the-dual-continua-model-on-a-national-sample-of-lesbian-gay-and-bisexual-identified-canadians
#12
Tracey Peter
The goal of the study is to investigate whether positive mental health complements mental illness within a theoretically informed (the dual-continua model) and psychometrically tested (the Mental Health Continuum-Short Form) framework. National-level, population-based data from the 2012 Canadian Community Health Survey on Mental Health (CCHS-MH) was used, with comparisons between sexual minority and heterosexual adults. Results show that gay, lesbian, and bisexual Canadians have substantially lower rates of positive mental health and are more likely to have been diagnosed with a mental illness, with the disparities between health and illness being the most pronounced among lesbians and bisexual females...
August 11, 2017: Journal of Homosexuality
https://www.readbyqxmd.com/read/28708033/neuropsychological-profile-and-social-cognition-in-congenital-central-hypoventilation-syndrome-cchs-correlation-with-neuroimaging-in-a-clinical-case
#13
Borja Esteso Orduña, Raquel Seijas Gómez, Elena García Esparza, Emily M Briceño, Javier Melero Llorente, María de la Concepción Fournier Del Castillo
INTRODUCTION: Congenital central hypoventilation syndrome (CCHS) is a rare genetic disorder due to paired-like homeobox gene (PHOX2B) mutations. CCHS patients suffer from dysregulation of the autonomic nervous system characterized by the absence of or extremely reduced response to hypercapnia and hypoxia, with neuropsychological deficits. The aim of this exploratory study is to describe the longitudinal neuropsychological profile and its correlations with magnetic resonance imaging (MRI) of a child with CCHS with a PHOX2B mutation...
July 14, 2017: Journal of Clinical and Experimental Neuropsychology
https://www.readbyqxmd.com/read/28672093/does-age-matter-comparing-post-treatment-psychosocial-outcomes-in-young-adult-and-older-adult-cancer-survivors-with-their-cancer-free-peers
#14
Michael Lang, Janine Giese-Davis, Scott Patten, David J T Campbell
OBJECTIVE: Adolescents and Young Adult cancer survivors (AYA) are a unique sub-population with high levels of distress and unmet need. To date studies have not disentangled distress due to developmental life stage from distress due to cancer survivorship. This population-based study allowed a direct comparison between AYA cancer survivors, Older Adult (OA) cancer survivors and their cancer-free peers. METHODS: We combined four annual cycles of the Canadian Community Health Survey (CCHS, 2007-2010) to obtain a final sample of 239,316 respondents...
July 3, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28636070/development-of-a-population-based-microsimulation-model-of-body-mass-index
#15
Deirdre Hennessy, Rochelle Garner, William M Flanagan Ron Wall And Claude Nadeau M Flanagan, Ron Wall, Claude Nadeau
BACKGROUND: The increasing prevalence of overweight and obesity has necessitated the development of body mass index (BMI) projection models such as the POpulation HEalth Model (POHEM). This study describes the POHEM-BMI model, a microsimulation tool that can be used to support evidence-based health policy making for obesity reduction. DATA AND METHODS: The National Population Health Survey, the Canadian Community Health Survey (CCHS), and the Canadian Health Measures Survey (CHMS) were used to develop and validate a predictive model of BMI for adults and childhood BMI history...
June 21, 2017: Health Reports
https://www.readbyqxmd.com/read/28633714/three-generation-family-with-congenital-central-hypoventilation-syndrome-and-novel-phox2b-gene-non-polyalanine-repeat-mutation
#16
Ajay S Kasi, Taryn J Jurgensen, Stephanie Yen, Sheila S Kun, Thomas G Keens, Iris A Perez
PHOX2B non-polyalanine repeat mutation (NPARM) in patients with congenital central hypoventilation syndrome (CCHS) is generally considered to be associated with full-time ventilator dependence and severe autonomic nervous system dysfunction. We report a three-generation family with four individuals possessing a novel PHOX2B NPARM (c.245C > T) with variable phenotypes. This mutation was inherited in an autosomal dominant pattern with variable penetrance. The affected family members with CCHS have a milder phenotype than is typically expected with a NPARM...
July 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28631060/estimating-the-size-of-the-msm-population-in-metro-vancouver-canada-using-multiple-methods-and-diverse-data-sources
#17
Ashleigh J Rich, Nathan J Lachowsky, Paul Sereda, Zishan Cui, Jason Wong, Stanley Wong, Jody Jollimore, Henry Fisher Raymond, Travis Salway Hottes, Eric A Roth, Robert S Hogg, David M Moore
Men who have sex with men (MSM) are disproportionately affected by HIV globally, regionally in Canada, and locally in Vancouver. Lack of reliable population size estimates of MSM impedes effective implementation of health care services and limits our understanding of the HIV epidemic. We estimated the population size of MSM residing in Metro Vancouver drawing on four data sources: the Canadian Community Health Survey (CCHS), a cross-sectional bio-behavioural MSM survey, HIV testing services data from sexually transmitted infection (STI) clinics serving MSM, and online social networking site Facebook...
June 19, 2017: Journal of Urban Health: Bulletin of the New York Academy of Medicine
https://www.readbyqxmd.com/read/28621649/a-natural-experimental-study-of-the-protective-effect-of-home-ownership-on-household-food-insecurity-in-canada-before-and-after-a-recession-2008-2009
#18
Lynn McIntyre, Xiuyun Wu, Cynthia Kwok, J C Herbert Emery
OBJECTIVES: Home ownership as opposed to renting is associated with lower rates of food insecurity, the latter being a marker of household economic deprivation associated with adverse health outcomes. It is unclear whether this relationship persists during a major economic decline, or whether different subgroups of home owners are equally protected. The 2008-2009 recession in Canada was tied to events in the United States related to inappropriate mortgage financing; the impact of the recession on food insecurity among home owners may identify policies to mitigate recessionary outcomes...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28616935/service-use-and-unmet-needs-for-substance-use-and-mental-disorders-in-canada
#19
Karen Urbanoski, Dakota Inglis, Scott Veldhuizen
OBJECTIVE: To investigate patterns and predictors of help seeking and met/unmet needs for mental health care in a national population health survey. METHOD: Participants were respondents to the 2012 Canadian Community Health Survey on Mental Health (CCHS-MH; n = 25,133). We used regression to identify the diagnostic and sociodemographic predictors of the use of informal supports, primary care, and specialist care, as well as perceived unmet needs. RESULTS: Eleven percent of Canadians reported using professionally led services for mental health or substance use in 2012, while another 9% received informal supports...
August 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28614046/cancer-risk-factors-and-screening-in-first-nations-in-ontario
#20
Maegan V Mazereeuw, Alexander Yurkiewich, Sehar Jamal, Caroline Cawley, Carmen R Jones, Loraine D Marrett
INTRODUCTION: A lack of identifiers in health administrative databases limits our understanding of the cancer burden in First Nations. This study compares cancer risk factors and screening between First Nations in Ontario (on and off reserve) and non-Aboriginal Ontarians using two unique health surveys. METHODS: We measured age-standardized prevalence estimates using the First Nations Regional Health Survey (RHS) Phase 2, 2008/10 (for First Nations on reserve) and the Canadian Community Health Survey (CCHS), 2007-2013 (for First Nations off reserve and non-Aboriginal Ontarians)...
June 2017: Health Promotion and Chronic Disease Prevention in Canada
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