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https://www.readbyqxmd.com/read/29327497/congenital-central-hypoventilation-syndrome-broader-cognitive-deficits-revealed-by-parent-controls
#1
Frank A Zelko, Tracey M Stewart, Cindy D Brogadir, Casey M Rand, Debra E Weese-Mayer
OBJECTIVE: To investigate neurocognitive deficits in children with Congenital Central Hypoventilation Syndrome (CCHS) by comparing them to their parents, since parents comprise a particularly suitable control group matched on disease-extrinsic factors that can influence neurocognitive functioning. We compared CCHS patients to their parents and to population norms, hypothesizing that they would obtain lower intelligence test scores than both groups. We also compared patient-parent differences against patient-normative differences, to determine whether the two analytic approaches would yield different results...
January 12, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29288778/child-abuse-and-work-stress-in-adulthood-evidence-from-a-population-based-study
#2
Hugues Sampasa-Kanyinga, Wendy Nilsen, Ian Colman
The objective of this study was to examine the association between child abuse and work stress in adulthood. We used data from the 2012 Canadian Community Health Survey (CCHS) Mental Health, a nationally representative cross-sectional survey of Canadians. This study included all participants aged 20years or older who reported being employed the past 12months (N=14,581). Child physical abuse, sexual abuse, and exposure to intimate partner violence were assessed in relation to several work stress-related indicators...
December 27, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/29286936/haddad-syndrome-novel-association-with-braf-mutation
#3
Suleiman Al Dakhoul
This is a report of a 36 week male infant who suffered abdominal distension and difficulty opening bowels within first few days of life and showed a pattern of hypoventilation and apnea associated with sleep. His diagnostic studies confirmed the diagnosis of congenital central hypoventilation syndrome CCHS (PHOX2B mutation) and Hirschsprung's disease and later found a further mutation of BRAF oncogene. This describes a novel association between these mutations and the shared qualities of tumorigenesis between BRAF and PHOX2B...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29284491/dental-care-use-in-ontario-the-canadian-community-health-survey-cchs
#4
Safoura Zangiabadi, Christy Costanian, Hala Tamim
BACKGROUND: Oral health is a significant measure of overall health, and regular dental visits are recommended for the maintenance of oral health. The purpose of this study is to determine the pattern (amount and type) of, and factors associated with dental care use among Ontarians. METHODS: Data from the 2014 cycle of the Canadian Community Health Survey was used and analysis was restricted to individuals aged 12 and above residing in Ontario. Dental care use was defined by two distinct outcomes: not visiting a dentist within the past year and visiting a dentist only for emergencies...
December 29, 2017: BMC Oral Health
https://www.readbyqxmd.com/read/29259798/the-relationship-between-health-eating-and-overweight-obesity-in-canada-cross-sectional-study-using-the-cchs
#5
H So, L McLaren, G C Currie
Objective: The relationship between Canada's Food Guide (CFG) adherence and overweight/obesity at the population level is unknown. Our objective was to explore the association between overweight/obesity and CFG adherence in Canada. Methods: Using 24-h dietary recall data from the Canadian Community Health Survey (CCHS), we conducted a cross-sectional analysis of Canadians' consumption of four predefined food types from CFG (grain products, vegetables and fruit, milk and alternatives, meat and alternatives)...
December 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29249648/congenital-central-hypoventilation-syndrome-an-overview-of-etiopathogenesis-associated-pathologies-clinical-presentation-and-management
#6
REVIEW
Saher Zaidi, Jason Gandhi, Sohrab Vatsia, Noel L Smith, Sardar Ali Khan
Congenital central hypoventilation syndrome (CCHS), known colloquially as Ondine's curse, is a rare disorder characterized by impaired autonomic control of breathing during sleep from the loss of vagal input and diminished sensitivity of CO2 receptors in the medulla. CCHS correlates to the malformation of the neural crest located in the brainstem; this consequently affects the loss of sensitivity of CO2 chemoreceptors, bringing about hypoventilation during sleep. The primary cause of CCHS is the mutation of the paired-like homeobox PHO2XB gene, found in 90% of the patients...
November 13, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/29189576/predicting-high-health-care-resource-utilization-in-a-single-payer-public-health-care-system-development-and-validation-of-the-high-resource-user-population-risk-tool-hruport
#7
Laura C Rosella, Kathy Kornas, Zhan Yao, Douglas G Manuel, Catherine Bornbaum, Randall Fransoo, Therese Stukel
BACKGROUND: A large proportion of health care spending is incurred by a small proportion of the population. Population-based health planning tools that consider both the clinical and upstream determinants of high resource users (HRU) of the health system are lacking. OBJECTIVE: To develop and validate the High Resource User Population Risk Tool (HRUPoRT), a predictive model of adults that will become the top 5% of health care users over a 5-year period, based on self-reported clinical, sociodemographic, and health behavioral predictors in population survey data...
November 17, 2017: Medical Care
https://www.readbyqxmd.com/read/29172812/validation-of-reported-concussion-within-a-national-health-survey
#8
Kevin E Gordon, Stefan Kuhle
SETTING: The Canadian Community Health Survey (CCHS) is a national cross-sectional health survey, which has collected information on injuries serious enough to limit normal activity. OBJECTIVE: To assess the construct and discriminant validity of reporting 'concussion or other brain injury' in the CCHS as the respondents' most serious injury. METHODS: Construct validity was assessed by describing the injury profile. Discriminant validity was assessed by examining differences between those reporting concussion or other brain injury, and either: respondents not reporting brain injury (population control); or respondents reporting orthopaedic injuries (orthopaedic control)...
2018: Brain Injury: [BI]
https://www.readbyqxmd.com/read/29147950/mental-health-consultation-among-ontario-s-immigrant-populations
#9
Farah Islam, Nazilla Khanlou, Alison Macpherson, Hala Tamim
To determine the prevalence rates and characteristics of past-year mental health consultation for Ontario's adult (18 + years old) immigrant populations. The Canadian Community Health Survey (CCHS) 2012 was used to calculate the prevalence rates of past-year mental health consultation by service provider type. Characteristics associated with mental health consultation were determined by carrying out multivariable logistic regression analysis on merged CCHS 2008-2012 data. Adult immigrant populations in Ontario (n = 3995) had lower estimated prevalence rates of past-year mental health consultation across all service provider types compared to Canadian-born populations (n = 14,644)...
November 16, 2017: Community Mental Health Journal
https://www.readbyqxmd.com/read/29133784/gyri-like-proteins-catalyze-cyclopropanoid-hydrolysis-to-confer-cellular-protection
#10
Hua Yuan, Jinru Zhang, Yujuan Cai, Sheng Wu, Kui Yang, H C Stephen Chan, Wei Huang, Wen-Bing Jin, Yan Li, Yue Yin, Yasuhiro Igarashi, Shuguang Yuan, Jiahai Zhou, Gong-Li Tang
GyrI-like proteins are widely distributed in prokaryotes and eukaryotes, and recognized as small-molecule binding proteins. Here, we identify a subfamily of these proteins as cyclopropanoid cyclopropyl hydrolases (CCHs) that can catalyze the hydrolysis of the potent DNA-alkylating agents yatakemycin (YTM) and CC-1065. Co-crystallography and molecular dynamics simulation analyses reveal that these CCHs share a conserved aromatic cage for the hydrolytic activity. Subsequent cytotoxic assays confirm that CCHs are able to protect cells against YTM...
November 14, 2017: Nature Communications
https://www.readbyqxmd.com/read/29098737/structural-and-functional-differences-in-phox2b-frameshift-mutations-underlie-isolated-or-syndromic-congenital-central-hypoventilation-syndrome
#11
Simona Di Lascio, Roberta Benfante, Eleonora Di Zanni, Silvia Cardani, Annalisa Adamo, Diego Fornasari, Isabella Ceccherini, Tiziana Bachetti
Heterozygous mutations in the PHOX2B gene are causative of Congenital Central Hypoventilation Syndrome (CCHS), a neurocristopathy characterised by defective autonomic control of breathing due to the impaired differentiation of neural crest cells (NCCs). Among PHOX2B mutations, polyalanine (polyAla) expansions are almost exclusively associated with isolated CCHS, whereas frameshift variants, although less frequent, are often more severe than polyAla expansions and identified in syndromic CCHS. This paper provides a complete review of all the frameshift mutations identified in cases of isolated and syndromic CCHS reported in the literature as well as those identified by us and not yet published...
November 2, 2017: Human Mutation
https://www.readbyqxmd.com/read/29092135/key-on-demand-kod-for-software-defined-optical-networks-secured-by-quantum-key-distribution-qkd
#12
Yuan Cao, Yongli Zhao, Carlos Colman-Meixner, Xiaosong Yu, Jie Zhang
Software-defined optical networking (SDON) will become the next generation optical network architecture. However, the optical layer and control layer of SDON are vulnerable to cyberattacks. While, data encryption is an effective method to minimize the negative effects of cyberattacks, secure key interchange is its major challenge which can be addressed by the quantum key distribution (QKD) technique. Hence, in this paper we discuss the integration of QKD with WDM optical networks to secure the SDON architecture by introducing a novel key on demand (KoD) scheme which is enabled by a novel routing, wavelength and key assignment (RWKA) algorithm...
October 30, 2017: Optics Express
https://www.readbyqxmd.com/read/29070641/dementia-population-risk-tool-demport-study-protocol-for-a-predictive-algorithm-assessing-dementia-risk-in-the-community
#13
Stacey Fisher, Amy Hsu, Nassim Mojaverian, Monica Taljaard, Gregory Huyer, Douglas G Manuel, Peter Tanuseputro
INTRODUCTION: The burden of disease from dementia is a growing global concern as incidence increases dramatically with age, and average life expectancy has been increasing around the world. Planning for an ageing population requires reliable projections of dementia prevalence; however, existing population projections are simple and have poor predictive accuracy. The Dementia Population Risk Tool (DemPoRT) will predict incidence of dementia in the population setting using multivariable modelling techniques and will be used to project dementia prevalence...
October 24, 2017: BMJ Open
https://www.readbyqxmd.com/read/28992836/carbamazepine-improves-apneic-episodes-in-congenital-central-hypoventilation-syndrome-cchs-with-a-novel-phox2b-exon-1-missense-mutation
#14
Schaida Schirwani, Karen Pysden, Philip Chetcuti, Moira Blyth
Pathogenic variants in Paired-Like Homeobox 2B (PHOX2B) gene cause congenital central hypoventilation syndrome (CCHS), a rare disorder of the nervous system characterized by absent or reduced ventilatory response to hypoxia and hypercapnia. The focus of management in CCHS is optimizing ventilation. Thus far, no medication has proved effective in improving ventilation. Most CCHS cases are caused by polyalanine repeat expansion mutations. Non-polyalanine repeat expansion mutations are the cause in 8% of cases and result in a more severe clinical presentation...
November 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28930364/nutritional-risk-hospitalization-and-mortality-among-community-dwelling-canadians-aged-65-or-older
#15
Pamela L Ramage-Morin, Heather Gilmour, Michelle Rotermann
BACKGROUND: Nutritional risk has been associated with various negative health outcomes among older people. Limited longitudinal research has examined the relationship between nutritional risk and hospitalization and death in community-dwelling older people. DATA AND METHODS: Data from the 2008/2009 Canadian Community Health Survey-Healthy Aging (CCHS-HA) linked to the Discharge Abstract Database and the Canadian Mortality Database were used to estimate the prevalence of nutritional risk among seniors and examine its relationship with acute care hospitalization and death during the 25- to 36-month period following the CCHS-HA interview...
September 20, 2017: Health Reports
https://www.readbyqxmd.com/read/28910259/estimation-of-smoking-prevalence-in-canada-implications-of-survey-characteristics-in-the-cchs-and-ctums-ctads
#16
Thierry Gagné
One of the main enterprises associated with tobacco control is surveillance, that is, to measure and follow over time the extent of smoking among the Canadian population. While surveillance systems have been in place for more than 50 years, knowing the exact prevalence of smoking in Canada continues to be a complex matter and understanding its estimation requires a critical appreciation of our national surveys' idiosyncrasies. This commentary describes the two Statistics Canada surveys that are most commonly used to examine smoking prevalence in this country: the Canadian Community Health Survey (CCHS) and the Canadian Tobacco, Alcohol and Drugs Survey (CTADS)...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28910244/inequalities-in-oral-health-understanding-the-contributions-of-education-and-income
#17
Julie Farmer, Rebecca C Phillips, Sonica Singhal, Carlos Quiñonez
OBJECTIVE: To quantify the extent to which income and education explain gradients in oral health outcomes. METHODS: Using data from the Canadian Community Health Survey (CCHS 2003), binary logistic regression models were constructed to examine the relationship between income and education on self-reported oral health (SROH) and chewing difficulties (CD) while controlling for age, sex, ethnicity, employment status and dental insurance coverage. The relative index of inequality (RII) was utilized to quantify the extent to which income and education explain gradients in poor SROH and CD...
September 14, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28861609/mir-375-and-yap1-expression-profiling-in-medullary-thyroid-carcinoma-and-their-correlation-with-clinical-pathological-features-and-outcome
#18
Francesca Galuppini, Loris Bertazza, Susi Barollo, Elisabetta Cavedon, Massimo Rugge, Vincenza Guzzardo, Diana Sacchi, Sara Watutantrige-Fernando, Federica Vianello, Caterina Mian, Gianmaria Pennelli
Medullary thyroid cancer (MTC) is a tumor marked by an indolent growth for which few prognostic factors and therapeutic strategies are actually available. Different studies have recently appraised well-differentiated thyroid cancers are characterized by a dysregulation in different microRNA sets; however, only few of them investigated the role of miRNA expression in MTCs. In this study, we have assessed the miR-375 expression in a series of 130 MTCs (104 are sporadic and 26 familial) with a median follow-up of 39 months (range 1-138) and then we have correlated our results with the clinical-pathological features and the patients' outcome...
November 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28847012/accuracy-of-cardiovascular-risk-prediction-varies-by-neighborhood-socioeconomic-position-a-retrospective-cohort-study
#19
Jarrod E Dalton, Adam T Perzynski, David A Zidar, Michael B Rothberg, Claudia J Coulton, Alex T Milinovich, Douglas Einstadter, James K Karichu, Neal V Dawson
Background: Inequality in health outcomes in relation to Americans' socioeconomic position is rising. Objective: First, to evaluate the spatial relationship between neighborhood disadvantage and major atherosclerotic cardiovascular disease (ASCVD)-related events; second, to evaluate the relative extent to which neighborhood disadvantage and physiologic risk account for neighborhood-level variation in ASCVD event rates. Design: Observational cohort analysis of geocoded longitudinal electronic health records...
October 3, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28800279/more-than-a-feeling-an-empirical-analysis-of-the-dual-continua-model-on-a-national-sample-of-lesbian-gay-and-bisexual-identified-canadians
#20
Tracey Peter
The goal of the study is to investigate whether positive mental health complements mental illness within a theoretically informed (the dual-continua model) and psychometrically tested (the Mental Health Continuum-Short Form) framework. National-level, population-based data from the 2012 Canadian Community Health Survey on Mental Health (CCHS-MH) was used, with comparisons between sexual minority and heterosexual adults. Results show that gay, lesbian, and bisexual Canadians have substantially lower rates of positive mental health and are more likely to have been diagnosed with a mental illness, with the disparities between health and illness being the most pronounced among lesbians and bisexual females...
August 11, 2017: Journal of Homosexuality
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